METTL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.27860896
2ATP synthesis coupled proton transport (GO:0015986)5.51639623
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51639623
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.12859750
5chaperone-mediated protein transport (GO:0072321)5.12137390
6proteasome assembly (GO:0043248)5.11013131
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.09463743
8DNA deamination (GO:0045006)5.07857795
9ribosomal small subunit assembly (GO:0000028)4.88755755
10respiratory electron transport chain (GO:0022904)4.61907748
11electron transport chain (GO:0022900)4.53682830
12protein neddylation (GO:0045116)4.48188291
13telomere maintenance via semi-conservative replication (GO:0032201)4.37892152
14purine nucleobase biosynthetic process (GO:0009113)4.17128142
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.14342994
16termination of RNA polymerase III transcription (GO:0006386)4.14342994
17DNA strand elongation involved in DNA replication (GO:0006271)4.10830092
18rRNA modification (GO:0000154)4.07972161
19nucleobase biosynthetic process (GO:0046112)4.06940161
20maturation of SSU-rRNA (GO:0030490)4.04148560
21CENP-A containing nucleosome assembly (GO:0034080)3.98544987
22DNA strand elongation (GO:0022616)3.97142560
23DNA replication initiation (GO:0006270)3.93688238
24telomere maintenance via recombination (GO:0000722)3.92807824
25chromatin remodeling at centromere (GO:0031055)3.90987105
26pseudouridine synthesis (GO:0001522)3.84275835
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82415156
28ribosomal large subunit biogenesis (GO:0042273)3.81653681
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81465784
30ribosome biogenesis (GO:0042254)3.79656356
31regulation of mitochondrial translation (GO:0070129)3.76217978
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76156875
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75455503
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73187002
357-methylguanosine mRNA capping (GO:0006370)3.72651066
36ribonucleoprotein complex biogenesis (GO:0022613)3.72317895
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70979347
38RNA capping (GO:0036260)3.68818681
397-methylguanosine RNA capping (GO:0009452)3.68818681
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67042783
41protein targeting to mitochondrion (GO:0006626)3.66083913
42transcription-coupled nucleotide-excision repair (GO:0006283)3.64856103
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60652260
44cytochrome complex assembly (GO:0017004)3.58567410
45formation of translation preinitiation complex (GO:0001731)3.54493396
46mitotic recombination (GO:0006312)3.54139158
47telomere maintenance via telomere lengthening (GO:0010833)3.53746631
48ribosomal small subunit biogenesis (GO:0042274)3.53466845
49oxidative phosphorylation (GO:0006119)3.49704682
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49110680
51regulation of cellular amino acid metabolic process (GO:0006521)3.48916076
52cullin deneddylation (GO:0010388)3.47238002
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47104408
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47104408
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47104408
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45979888
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45979888
58protein localization to mitochondrion (GO:0070585)3.45906556
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45528570
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45528570
61spliceosomal snRNP assembly (GO:0000387)3.45417173
62DNA replication checkpoint (GO:0000076)3.45204424
63DNA double-strand break processing (GO:0000729)3.44151702
64transcription from RNA polymerase I promoter (GO:0006360)3.43477735
65establishment of protein localization to mitochondrion (GO:0072655)3.41918269
66maturation of 5.8S rRNA (GO:0000460)3.41880615
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41536198
68negative regulation of ligase activity (GO:0051352)3.41536198
69kinetochore organization (GO:0051383)3.40167095
70rRNA processing (GO:0006364)3.39563014
71cellular component biogenesis (GO:0044085)3.39372214
72rRNA methylation (GO:0031167)3.38742378
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.38300448
74protein deneddylation (GO:0000338)3.37286781
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36847227
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.36847227
77termination of RNA polymerase I transcription (GO:0006363)3.36035306
78water-soluble vitamin biosynthetic process (GO:0042364)3.35300646
79kinetochore assembly (GO:0051382)3.34401972
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.34312214
81NADH dehydrogenase complex assembly (GO:0010257)3.34312214
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34312214
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.34022107
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33270464
85protein-cofactor linkage (GO:0018065)3.31208702
86rRNA metabolic process (GO:0016072)3.30827964
87DNA replication-independent nucleosome organization (GO:0034724)3.28253926
88DNA replication-independent nucleosome assembly (GO:0006336)3.28253926
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27753569
90DNA damage response, detection of DNA damage (GO:0042769)3.24552302
91mitotic metaphase plate congression (GO:0007080)3.24370331
92viral transcription (GO:0019083)3.23984015
93translation (GO:0006412)3.23069807
942-deoxyribonucleotide biosynthetic process (GO:0009265)3.22480100
95deoxyribose phosphate biosynthetic process (GO:0046385)3.22480100
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19770007
97translational termination (GO:0006415)3.19116627
98respiratory chain complex IV assembly (GO:0008535)3.18365247
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.17120497
100ATP biosynthetic process (GO:0006754)3.16183871
101IMP biosynthetic process (GO:0006188)3.15489068
102protein complex biogenesis (GO:0070271)3.14148865
103spliceosomal complex assembly (GO:0000245)3.14123973
104ribosome assembly (GO:0042255)3.13192563
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09660364
106purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08958628
107positive regulation of ligase activity (GO:0051351)3.07650070
108deoxyribonucleotide biosynthetic process (GO:0009263)3.07545539
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07408116
110viral life cycle (GO:0019058)3.05737897
111peptidyl-histidine modification (GO:0018202)3.05317036
112establishment of integrated proviral latency (GO:0075713)3.05127299
113G1/S transition of mitotic cell cycle (GO:0000082)3.04371910
114cell cycle G1/S phase transition (GO:0044843)3.04371910
115histone exchange (GO:0043486)3.04230905
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03698061
117cotranslational protein targeting to membrane (GO:0006613)3.02412230
118regulation of nuclear cell cycle DNA replication (GO:0033262)3.02170727
119translational elongation (GO:0006414)3.01885659
120cellular protein complex disassembly (GO:0043624)2.99576013
121viral mRNA export from host cell nucleus (GO:0046784)2.98490003
122intracellular protein transmembrane import (GO:0044743)2.98416497
123mitochondrial respiratory chain complex assembly (GO:0033108)2.97893837
124protein targeting to ER (GO:0045047)2.97680118
125amino acid salvage (GO:0043102)2.97060012
126L-methionine salvage (GO:0071267)2.97060012
127L-methionine biosynthetic process (GO:0071265)2.97060012
128deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96377575
129tRNA methylation (GO:0030488)2.96299525
130histone mRNA metabolic process (GO:0008334)2.95977625
131replication fork processing (GO:0031297)2.95545234
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95012626
133translational initiation (GO:0006413)2.94867668
134protein localization to endoplasmic reticulum (GO:0070972)2.94534835
135DNA catabolic process, exonucleolytic (GO:0000738)2.94378481
136mitochondrial transport (GO:0006839)2.92980378
137regulation of mitotic spindle checkpoint (GO:1903504)2.92662341
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92662341
139hydrogen ion transmembrane transport (GO:1902600)2.90297152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.11485971
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37395967
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.22138025
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79050398
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.75309254
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.71871721
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53722505
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.38559620
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23170735
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22951440
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01440855
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00903037
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93203164
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90078435
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85785895
16VDR_23849224_ChIP-Seq_CD4+_Human2.78241282
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71831663
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61192648
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59287821
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54992899
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54794596
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50182437
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39493123
24FOXP3_21729870_ChIP-Seq_TREG_Human2.33422682
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.28438028
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27663210
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26998532
28XRN2_22483619_ChIP-Seq_HELA_Human2.22412365
29DCP1A_22483619_ChIP-Seq_HELA_Human2.21685297
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15431027
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14900452
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11751572
33ELK1_19687146_ChIP-ChIP_HELA_Human2.10176156
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.07852249
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07312922
36GABP_19822575_ChIP-Seq_HepG2_Human2.01465934
37VDR_22108803_ChIP-Seq_LS180_Human1.95788749
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91640184
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90476481
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83508714
41EWS_26573619_Chip-Seq_HEK293_Human1.80727164
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80655698
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78275857
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77457173
45TTF2_22483619_ChIP-Seq_HELA_Human1.76099610
46ZNF274_21170338_ChIP-Seq_K562_Hela1.75327319
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74327961
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73111974
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.71290059
50* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70463067
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67780349
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67611073
53FUS_26573619_Chip-Seq_HEK293_Human1.66104323
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59408516
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56206516
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.49632170
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47350174
58AR_21909140_ChIP-Seq_LNCAP_Human1.44083488
59CIITA_25753668_ChIP-Seq_RAJI_Human1.43891903
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.42993553
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41059230
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.34688481
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33123007
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32394149
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32010540
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31112736
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.31053338
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27921958
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26816841
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24944726
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23620546
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22480087
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21858534
74KDM5A_27292631_Chip-Seq_BREAST_Human1.20706238
75MYC_18940864_ChIP-ChIP_HL60_Human1.18364832
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17938749
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.15521254
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14212445
79IGF1R_20145208_ChIP-Seq_DFB_Human1.14085909
80TAF15_26573619_Chip-Seq_HEK293_Human1.12397985
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10840049
82* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07737750
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07292800
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06231883
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.06121082
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.04753663
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04425361
88TP53_22573176_ChIP-Seq_HFKS_Human1.03922806
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03320803
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02583751
91SPI1_23547873_ChIP-Seq_NB4_Human1.00343953
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00210018
93IRF1_19129219_ChIP-ChIP_H3396_Human0.99278517
94P300_19829295_ChIP-Seq_ESCs_Human0.98616271
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98547577
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98241617
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96093194
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95881272
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94966630
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93883684
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93826493
102TFEB_21752829_ChIP-Seq_HELA_Human0.93401889
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89091067
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88765000
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86427615
106CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84348690
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83708089
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82449021
109SOX2_19829295_ChIP-Seq_ESCs_Human0.82257530
110NANOG_19829295_ChIP-Seq_ESCs_Human0.82257530
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.81458556
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81458556
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80961620
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80859499
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.78592814
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76976004
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76667352
118* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76572699
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75170688
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73746298
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.73422819
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73171079
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.70707787
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.69527066
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68242573
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66160383
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64400006
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.64124218
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.63122842
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62403499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51065344
2MP0004957_abnormal_blastocyst_morpholog4.15775670
3MP0010094_abnormal_chromosome_stability4.02463637
4MP0008058_abnormal_DNA_repair3.91799970
5MP0003111_abnormal_nucleus_morphology3.61246534
6MP0008057_abnormal_DNA_replication3.45532924
7MP0003077_abnormal_cell_cycle3.28767132
8MP0002396_abnormal_hematopoietic_system3.20241107
9MP0003806_abnormal_nucleotide_metabolis3.08345734
10MP0008007_abnormal_cellular_replicative2.75867058
11MP0003186_abnormal_redox_activity2.51209547
12MP0008932_abnormal_embryonic_tissue2.49263529
13MP0003786_premature_aging2.34554776
14MP0002837_dystrophic_cardiac_calcinosis2.29973484
15MP0009697_abnormal_copulation2.26169581
16MP0005075_abnormal_melanosome_morpholog2.21512896
17MP0002132_abnormal_respiratory_system2.20184048
18MP0006072_abnormal_retinal_apoptosis2.20093187
19MP0003718_maternal_effect2.17640689
20MP0006036_abnormal_mitochondrial_physio2.07675568
21MP0000490_abnormal_crypts_of1.99273698
22MP0008877_abnormal_DNA_methylation1.91915621
23MP0002102_abnormal_ear_morphology1.91605010
24MP0005084_abnormal_gallbladder_morpholo1.87936128
25MP0001293_anophthalmia1.82795816
26MP0009379_abnormal_foot_pigmentation1.79394261
27MP0001764_abnormal_homeostasis1.76686002
28MP0006292_abnormal_olfactory_placode1.73038990
29MP0003123_paternal_imprinting1.72254050
30MP0001986_abnormal_taste_sensitivity1.69271343
31MP0005671_abnormal_response_to1.61902361
32MP0003656_abnormal_erythrocyte_physiolo1.61206796
33MP0008789_abnormal_olfactory_epithelium1.58169763
34MP0003763_abnormal_thymus_physiology1.58005596
35MP0002163_abnormal_gland_morphology1.54775580
36MP0003880_abnormal_central_pattern1.54106891
37MP0003890_abnormal_embryonic-extraembry1.51455061
38MP0003941_abnormal_skin_development1.49577587
39MP0008995_early_reproductive_senescence1.48789588
40MP0002736_abnormal_nociception_after1.47486734
41MP0006035_abnormal_mitochondrial_morpho1.43661664
42MP0002095_abnormal_skin_pigmentation1.43010907
43MP0009333_abnormal_splenocyte_physiolog1.41336367
44MP0008260_abnormal_autophagy1.40201803
45MP0001835_abnormal_antigen_presentation1.38688225
46MP0000350_abnormal_cell_proliferation1.36928244
47MP0004147_increased_porphyrin_level1.36672471
48MP0004133_heterotaxia1.36098444
49MP0003011_delayed_dark_adaptation1.35614215
50MP0005397_hematopoietic_system_phenotyp1.32934042
51MP0001545_abnormal_hematopoietic_system1.32934042
52MP0005253_abnormal_eye_physiology1.31758839
53MP0005551_abnormal_eye_electrophysiolog1.30794940
54MP0001485_abnormal_pinna_reflex1.29967667
55MP0004215_abnormal_myocardial_fiber1.29313172
56MP0004145_abnormal_muscle_electrophysio1.28231825
57MP0003122_maternal_imprinting1.26416567
58MP0001984_abnormal_olfaction1.26385488
59MP0003315_abnormal_perineum_morphology1.24423160
60MP0005379_endocrine/exocrine_gland_phen1.22839761
61MP0000313_abnormal_cell_death1.22676978
62MP0001853_heart_inflammation1.22108566
63MP0001730_embryonic_growth_arrest1.20074080
64MP0002019_abnormal_tumor_incidence1.18351572
65MP0002398_abnormal_bone_marrow1.17760440
66MP0005646_abnormal_pituitary_gland1.17568222
67MP0000631_abnormal_neuroendocrine_gland1.17384476
68MP0000689_abnormal_spleen_morphology1.13531026
69MP0002160_abnormal_reproductive_system1.12999741
70MP0003195_calcinosis1.12639390
71MP0005645_abnormal_hypothalamus_physiol1.11092678
72MP0005389_reproductive_system_phenotype1.10917980
73MP0008872_abnormal_physiological_respon1.10651078
74MP0003937_abnormal_limbs/digits/tail_de1.10554574
75MP0000647_abnormal_sebaceous_gland1.07158144
76MP0002722_abnormal_immune_system1.06968874
77MP0009785_altered_susceptibility_to1.06549834
78MP0001188_hyperpigmentation1.05537008
79MP0010030_abnormal_orbit_morphology1.04873846
80MP0005499_abnormal_olfactory_system1.04316687
81MP0005394_taste/olfaction_phenotype1.04316687
82MP0001286_abnormal_eye_development0.99798879
83MP0002210_abnormal_sex_determination0.99572475
84MP0006276_abnormal_autonomic_nervous0.98455909
85MP0000015_abnormal_ear_pigmentation0.98417348
86MP0004808_abnormal_hematopoietic_stem0.97158278
87MP0002429_abnormal_blood_cell0.96914488
88MP0000703_abnormal_thymus_morphology0.96253626
89MP0000465_gastrointestinal_hemorrhage0.94498078
90MP0001968_abnormal_touch/_nociception0.94267726
91MP0009046_muscle_twitch0.93841240
92MP0000372_irregular_coat_pigmentation0.93527924
93MP0001119_abnormal_female_reproductive0.93248309
94MP0001529_abnormal_vocalization0.93061091
95MP0002148_abnormal_hypersensitivity_rea0.91332533
96MP0000716_abnormal_immune_system0.90466204
97MP0000358_abnormal_cell_content/0.89207219
98MP0002234_abnormal_pharynx_morphology0.89085465
99MP0002090_abnormal_vision0.88570144
100MP0002233_abnormal_nose_morphology0.88079784
101MP0002080_prenatal_lethality0.88061285
102MP0003119_abnormal_digestive_system0.87673602
103MP0002938_white_spotting0.87618810
104MP0002653_abnormal_ependyma_morphology0.87199329
105MP0003724_increased_susceptibility_to0.86937769
106MP0001145_abnormal_male_reproductive0.86931543
107MP0003136_yellow_coat_color0.86812529
108MP0001697_abnormal_embryo_size0.86507532
109MP0000049_abnormal_middle_ear0.85656543
110MP0001929_abnormal_gametogenesis0.83007441
111MP0001919_abnormal_reproductive_system0.82672989
112MP0002277_abnormal_respiratory_mucosa0.82385101
113MP0001800_abnormal_humoral_immune0.80862392
114MP0002420_abnormal_adaptive_immunity0.80773121
115MP0000653_abnormal_sex_gland0.79567394
116MP0005636_abnormal_mineral_homeostasis0.79176205
117MP0005408_hypopigmentation0.78518278
118MP0001819_abnormal_immune_cell0.78476311
119MP0001905_abnormal_dopamine_level0.76843168
120MP0008875_abnormal_xenobiotic_pharmacok0.76097399
121MP0005391_vision/eye_phenotype0.75622402
122MP0005380_embryogenesis_phenotype0.75591586
123MP0001672_abnormal_embryogenesis/_devel0.75591586
124MP0005266_abnormal_metabolism0.74427517
125MP0002723_abnormal_immune_serum0.74076801
126MP0000516_abnormal_urinary_system0.73869969
127MP0005367_renal/urinary_system_phenotyp0.73869969
128MP0002452_abnormal_antigen_presenting0.73118958
129MP0002876_abnormal_thyroid_physiology0.71489178
130MP0005195_abnormal_posterior_eye0.71271970
131MP0002751_abnormal_autonomic_nervous0.70135120
132MP0005085_abnormal_gallbladder_physiolo0.69095339
133MP0005174_abnormal_tail_pigmentation0.68438114
134MP0003137_abnormal_impulse_conducting0.68128282
135MP0004142_abnormal_muscle_tone0.67254925
136MP0002254_reproductive_system_inflammat0.67128191
137MP0005025_abnormal_response_to0.67015187
138MP0002638_abnormal_pupillary_reflex0.66698464
139MP0008469_abnormal_protein_level0.66687435
140MP0005410_abnormal_fertilization0.66410200
141MP0003121_genomic_imprinting0.66055351
142MP0010307_abnormal_tumor_latency0.65915889
143MP0001542_abnormal_bone_strength0.65112703
144MP0005464_abnormal_platelet_physiology0.63939409
145MP0003866_abnormal_defecation0.62497221
146MP0003567_abnormal_fetal_cardiomyocyte0.60615154
147MP0001186_pigmentation_phenotype0.60442360
148MP0003787_abnormal_imprinting0.59876568
149MP0005332_abnormal_amino_acid0.59332678
150MP0003984_embryonic_growth_retardation0.59279844
151MP0009672_abnormal_birth_weight0.58514731
152MP0010352_gastrointestinal_tract_polyps0.58395427

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.58114095
2Abnormal number of erythroid precursors (HP:0012131)3.98171918
3Abnormality of cells of the erythroid lineage (HP:0012130)3.92923629
4Acute necrotizing encephalopathy (HP:0006965)3.87792752
5Hepatocellular necrosis (HP:0001404)3.83441000
6Aplastic anemia (HP:0001915)3.81829970
7Mitochondrial inheritance (HP:0001427)3.71322582
8Increased CSF lactate (HP:0002490)3.69028403
9Abnormal mitochondria in muscle tissue (HP:0008316)3.65445191
10Hepatic necrosis (HP:0002605)3.58133689
113-Methylglutaconic aciduria (HP:0003535)3.44723578
12Type I transferrin isoform profile (HP:0003642)3.44352568
13Reticulocytopenia (HP:0001896)3.41677649
14Oral leukoplakia (HP:0002745)3.37888465
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33382974
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33382974
17Microvesicular hepatic steatosis (HP:0001414)3.26760567
18Increased serum lactate (HP:0002151)3.24139095
19Acute encephalopathy (HP:0006846)3.23118976
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.21285604
21Cerebral hypomyelination (HP:0006808)3.20340930
22Breast hypoplasia (HP:0003187)3.14140116
23Progressive macrocephaly (HP:0004481)3.09846123
24Methylmalonic acidemia (HP:0002912)3.09040674
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07804655
26Chromsome breakage (HP:0040012)3.02634396
27Increased hepatocellular lipid droplets (HP:0006565)3.01419179
28Rough bone trabeculation (HP:0100670)2.84639080
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83175617
30Lactic acidosis (HP:0003128)2.81617853
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78528140
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78300870
33Lipid accumulation in hepatocytes (HP:0006561)2.74008954
34Abnormality of the anterior horn cell (HP:0006802)2.72911838
35Degeneration of anterior horn cells (HP:0002398)2.72911838
36Type 2 muscle fiber atrophy (HP:0003554)2.71962144
37Methylmalonic aciduria (HP:0012120)2.64497408
38Carpal bone hypoplasia (HP:0001498)2.62851260
39Abnormality of the preputium (HP:0100587)2.61690814
40Reduced antithrombin III activity (HP:0001976)2.58809175
41Macrocytic anemia (HP:0001972)2.58407353
42Pallor (HP:0000980)2.53009544
43Cerebral edema (HP:0002181)2.52120565
44Abnormal protein glycosylation (HP:0012346)2.51306581
45Abnormal glycosylation (HP:0012345)2.51306581
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51306581
47Abnormal protein N-linked glycosylation (HP:0012347)2.51306581
48Pancreatic cysts (HP:0001737)2.50742705
49Pancreatic fibrosis (HP:0100732)2.50296061
50Abnormality of renal resorption (HP:0011038)2.48225633
51Exercise intolerance (HP:0003546)2.47379945
52Optic disc pallor (HP:0000543)2.46504313
53Colon cancer (HP:0003003)2.44791867
54Molar tooth sign on MRI (HP:0002419)2.44550240
55Abnormality of midbrain morphology (HP:0002418)2.44550240
56Absent thumb (HP:0009777)2.43225349
57Medial flaring of the eyebrow (HP:0010747)2.43149217
58Abnormality of chromosome stability (HP:0003220)2.42504765
59Pancytopenia (HP:0001876)2.41300217
60Premature graying of hair (HP:0002216)2.40119285
61Muscle fiber atrophy (HP:0100295)2.39618179
62Abnormality of the labia minora (HP:0012880)2.39527969
63IgM deficiency (HP:0002850)2.37708208
64Respiratory failure (HP:0002878)2.37336518
65Sparse eyelashes (HP:0000653)2.36735819
66Renal Fanconi syndrome (HP:0001994)2.35968918
67True hermaphroditism (HP:0010459)2.34287159
68Hyperglycinemia (HP:0002154)2.32924455
69Abnormality of urine glucose concentration (HP:0011016)2.32762168
70Glycosuria (HP:0003076)2.32762168
71CNS demyelination (HP:0007305)2.31930094
72Bone marrow hypocellularity (HP:0005528)2.29695798
73Increased intramyocellular lipid droplets (HP:0012240)2.27213250
74Abnormality of serum amino acid levels (HP:0003112)2.23879463
75Meckel diverticulum (HP:0002245)2.23749411
76Abnormality of methionine metabolism (HP:0010901)2.23266828
77Congenital, generalized hypertrichosis (HP:0004540)2.22376486
78Respiratory difficulties (HP:0002880)2.21334295
79Myelodysplasia (HP:0002863)2.19282314
80Patellar aplasia (HP:0006443)2.18239198
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16744929
82Abnormality of alanine metabolism (HP:0010916)2.16744929
83Hyperalaninemia (HP:0003348)2.16744929
84Exertional dyspnea (HP:0002875)2.15840304
85Abnormality of the ileum (HP:0001549)2.12710564
86Aplasia/Hypoplasia of the patella (HP:0006498)2.10545448
87Abnormal trabecular bone morphology (HP:0100671)2.09012374
88Septo-optic dysplasia (HP:0100842)2.04755772
89Nephronophthisis (HP:0000090)2.04082561
90Congenital primary aphakia (HP:0007707)2.03884425
91Petechiae (HP:0000967)2.02300193
92Abnormality of glycolysis (HP:0004366)2.02013631
93Increased serum pyruvate (HP:0003542)2.02013631
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01218462
95Thrombocytosis (HP:0001894)1.98962588
96Gait imbalance (HP:0002141)1.96848487
97Cellular immunodeficiency (HP:0005374)1.96703905
98X-linked dominant inheritance (HP:0001423)1.96175566
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.95923962
100Aplasia/hypoplasia of the uterus (HP:0008684)1.93907276
101Sclerocornea (HP:0000647)1.93688573
102Abnormal spermatogenesis (HP:0008669)1.92882474
103Abnormal lung lobation (HP:0002101)1.91235036
104Increased muscle lipid content (HP:0009058)1.90598812
105Hyperphosphaturia (HP:0003109)1.90213913
106CNS hypomyelination (HP:0003429)1.89981090
107Generalized aminoaciduria (HP:0002909)1.89571682
108Abnormality of pyrimidine metabolism (HP:0004353)1.89328247
109Lethargy (HP:0001254)1.89154615
11011 pairs of ribs (HP:0000878)1.89108227
111Secondary amenorrhea (HP:0000869)1.87726647
112Microretrognathia (HP:0000308)1.87566995
113Stenosis of the external auditory canal (HP:0000402)1.87521445
114Medulloblastoma (HP:0002885)1.87426990
115Nephrogenic diabetes insipidus (HP:0009806)1.86621797
116Abnormality of vitamin B metabolism (HP:0004340)1.86107855
117Duplicated collecting system (HP:0000081)1.84742728
118Triphalangeal thumb (HP:0001199)1.82033393
119Leukodystrophy (HP:0002415)1.81711292
120Lymphoma (HP:0002665)1.81065040
121Dry hair (HP:0011359)1.78933148
122Prolonged bleeding time (HP:0003010)1.78195443
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78027409
124Dicarboxylic aciduria (HP:0003215)1.78027409
125Poor head control (HP:0002421)1.77673356
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.77098449
127Genital tract atresia (HP:0001827)1.76991250
128Megaloblastic anemia (HP:0001889)1.75472470
129Progressive muscle weakness (HP:0003323)1.75218496
130Abnormality of the renal collecting system (HP:0004742)1.75179228
131Selective tooth agenesis (HP:0001592)1.74543138
132Unsteady gait (HP:0002317)1.74407040
133Nausea (HP:0002018)1.74273737
134Vaginal atresia (HP:0000148)1.72051314
135Hypoglycemic coma (HP:0001325)1.68902089
136Renal cortical cysts (HP:0000803)1.68085456
137Absent septum pellucidum (HP:0001331)1.64715381
138Abnormality of homocysteine metabolism (HP:0010919)1.63985036
139Homocystinuria (HP:0002156)1.63985036
140Median cleft lip (HP:0000161)1.63228070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.33441226
2EIF2AK13.92515164
3BUB13.82799266
4WEE13.44669426
5VRK23.11334038
6SRPK12.97005985
7EIF2AK32.87292268
8NME22.74530559
9VRK12.43167631
10MAP4K22.37052268
11TRIM282.29363275
12BRSK22.29163557
13TSSK62.22740270
14WNK32.21337410
15CDC72.21260383
16PLK42.19263182
17MKNK11.98108898
18MKNK21.93997592
19ZAK1.76417558
20ACVR1B1.65575632
21BCKDK1.51979086
22FRK1.50819778
23NME11.49023528
24PIM21.45203965
25AKT31.44788293
26PLK11.44547063
27BRSK11.42621203
28PLK31.37022659
29TXK1.34418108
30TTK1.33014506
31BRAF1.27484880
32IRAK31.26820736
33CDK81.26575947
34EIF2AK21.25299633
35PBK1.23130916
36CCNB11.22190968
37AURKB1.20935014
38CDK71.18222058
39ATR1.17624676
40MUSK1.15356395
41BCR1.15185869
42PDK21.12725238
43RPS6KA41.09708590
44AURKA1.09589735
45TEC1.08349566
46MAP3K41.06549131
47DYRK31.04462368
48NEK21.03280020
49PASK1.03063707
50TLK11.00930715
51NEK10.95861265
52IRAK40.93599248
53FLT30.91247196
54TAF10.89799348
55PNCK0.89410785
56EPHA20.88898410
57WNK40.85684815
58CSNK1G20.85221059
59RPS6KB20.85143856
60TESK20.84687049
61PLK20.83292347
62LIMK10.83055533
63CHEK20.82962522
64CSNK2A10.80654750
65MST40.78957563
66PIM10.77120860
67KIT0.76780713
68INSRR0.75513065
69CSNK2A20.75198403
70OXSR10.74189964
71KDR0.73711350
72STK30.73144661
73YES10.71382425
74PIK3CG0.70833060
75GRK70.70798244
76STK390.70240014
77PINK10.69823325
78MAPK130.69432477
79MAP4K10.69391513
80RPS6KA50.68991686
81ADRBK20.68766829
82BMPR1B0.67814137
83CASK0.65776042
84PHKG10.64256816
85PHKG20.64256816
86BTK0.63645881
87STK240.61100786
88CSNK1A1L0.57517224
89STK40.57065384
90PRKCG0.56992153
91BMPR20.56538357
92ARAF0.56193930
93CHEK10.54802577
94CSNK1G30.53910264
95TAOK20.52784499
96IKBKB0.52467337
97ABL20.52241607
98MAP3K120.52157741
99CDK190.51961678
100MAP3K80.49253288
101MAPK150.46906137
102ATM0.46393971
103CDK30.45563275
104PRKCE0.44925261
105MINK10.44358162
106GRK10.43861472
107LYN0.43593039
108CSNK1E0.43525105
109OBSCN0.42859067
110NUAK10.41243497
111ERBB40.39931620
112DAPK10.39810551
113TIE10.39652164
114DYRK20.39532973
115TNIK0.39302138
116PAK30.38903544
117CDK40.38847693
118CDK20.38722906
119SCYL20.37732471
120STK38L0.37698167
121CSNK1A10.37383030
122MAP2K70.37035227
123MAP2K60.36938793
124PRKCI0.36345417
125CSNK1G10.35410934
126FGFR10.34680713
127CSF1R0.34162807
128NEK90.33728681
129TGFBR10.33376381
130MYLK0.32396166
131CLK10.32293673
132ERBB30.32235917
133NEK60.32174541
134ZAP700.32129705
135MAPKAPK50.31651753
136ADRBK10.30959352
137PRKACA0.26164680
138CAMK2A0.26136299

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.22671760
2DNA replication_Homo sapiens_hsa030304.14211543
3RNA polymerase_Homo sapiens_hsa030203.80463050
4Ribosome_Homo sapiens_hsa030103.70912697
5Mismatch repair_Homo sapiens_hsa034303.52531515
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35862446
7Homologous recombination_Homo sapiens_hsa034402.97015582
8Pyrimidine metabolism_Homo sapiens_hsa002402.75869776
9Nucleotide excision repair_Homo sapiens_hsa034202.67753827
10Spliceosome_Homo sapiens_hsa030402.62581489
11Base excision repair_Homo sapiens_hsa034102.57036431
12RNA transport_Homo sapiens_hsa030132.31565338
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10588435
14Protein export_Homo sapiens_hsa030602.09906029
15Oxidative phosphorylation_Homo sapiens_hsa001902.09368478
16One carbon pool by folate_Homo sapiens_hsa006702.02342823
17Non-homologous end-joining_Homo sapiens_hsa034501.97503206
18Basal transcription factors_Homo sapiens_hsa030221.96815699
19Parkinsons disease_Homo sapiens_hsa050121.95109342
20Fanconi anemia pathway_Homo sapiens_hsa034601.94223189
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84744134
22RNA degradation_Homo sapiens_hsa030181.74295692
23Cell cycle_Homo sapiens_hsa041101.68222831
24Folate biosynthesis_Homo sapiens_hsa007901.64812943
25Purine metabolism_Homo sapiens_hsa002301.61397157
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60157576
27Huntingtons disease_Homo sapiens_hsa050161.59658936
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50613871
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49235138
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36514003
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23810063
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.15750797
33Vitamin B6 metabolism_Homo sapiens_hsa007501.14594238
34Steroid biosynthesis_Homo sapiens_hsa001001.12006956
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10719079
36Alzheimers disease_Homo sapiens_hsa050101.09798536
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09256156
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07014130
39Selenocompound metabolism_Homo sapiens_hsa004501.02320917
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00408593
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.99731982
42Butanoate metabolism_Homo sapiens_hsa006500.98696264
43Regulation of autophagy_Homo sapiens_hsa041400.96655151
44Pentose phosphate pathway_Homo sapiens_hsa000300.94989172
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91566508
46Epstein-Barr virus infection_Homo sapiens_hsa051690.90465544
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87155379
48Glutathione metabolism_Homo sapiens_hsa004800.86039243
49p53 signaling pathway_Homo sapiens_hsa041150.85522391
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82525780
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82279513
52mRNA surveillance pathway_Homo sapiens_hsa030150.82219661
53Phototransduction_Homo sapiens_hsa047440.79164173
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76632672
55Systemic lupus erythematosus_Homo sapiens_hsa053220.74178295
56Metabolic pathways_Homo sapiens_hsa011000.70172478
57Biosynthesis of amino acids_Homo sapiens_hsa012300.68798914
58Carbon metabolism_Homo sapiens_hsa012000.67348012
59Arachidonic acid metabolism_Homo sapiens_hsa005900.67026926
60Collecting duct acid secretion_Homo sapiens_hsa049660.64713988
61Herpes simplex infection_Homo sapiens_hsa051680.62581546
62Caffeine metabolism_Homo sapiens_hsa002320.62060567
63Peroxisome_Homo sapiens_hsa041460.61705611
64Sulfur relay system_Homo sapiens_hsa041220.61608048
65Fructose and mannose metabolism_Homo sapiens_hsa000510.61591160
66Primary immunodeficiency_Homo sapiens_hsa053400.61536455
67Nitrogen metabolism_Homo sapiens_hsa009100.59539240
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.58550457
69Antigen processing and presentation_Homo sapiens_hsa046120.57432389
70Tryptophan metabolism_Homo sapiens_hsa003800.57317027
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55644598
72Fatty acid degradation_Homo sapiens_hsa000710.49703494
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49261431
74Fatty acid metabolism_Homo sapiens_hsa012120.47862734
75Galactose metabolism_Homo sapiens_hsa000520.44496013
76Nicotine addiction_Homo sapiens_hsa050330.41380123
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41061406
78Legionellosis_Homo sapiens_hsa051340.39723539
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39312649
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.37865046
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.37394839
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36853182
83Propanoate metabolism_Homo sapiens_hsa006400.36684843
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.36608928
85Fat digestion and absorption_Homo sapiens_hsa049750.36565075
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36060484
87Pyruvate metabolism_Homo sapiens_hsa006200.35695526
88Other glycan degradation_Homo sapiens_hsa005110.35117031
89beta-Alanine metabolism_Homo sapiens_hsa004100.34587243
90Arginine and proline metabolism_Homo sapiens_hsa003300.34409452
91Fatty acid elongation_Homo sapiens_hsa000620.33707412
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32189623
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31622404
94N-Glycan biosynthesis_Homo sapiens_hsa005100.30918099
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29519522
96Chemical carcinogenesis_Homo sapiens_hsa052040.28390665
97Olfactory transduction_Homo sapiens_hsa047400.26911969
98Hematopoietic cell lineage_Homo sapiens_hsa046400.26703761
99Linoleic acid metabolism_Homo sapiens_hsa005910.26430126
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26080141
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24733437
102Ether lipid metabolism_Homo sapiens_hsa005650.24618254
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24584651
104Measles_Homo sapiens_hsa051620.23440909
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22745846
106Phenylalanine metabolism_Homo sapiens_hsa003600.22550833
107Viral carcinogenesis_Homo sapiens_hsa052030.22418624
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22308974
109Vitamin digestion and absorption_Homo sapiens_hsa049770.21880363
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20796772
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.20444072
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20095253
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.16709041
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16499788
115Oocyte meiosis_Homo sapiens_hsa041140.16146966
116Histidine metabolism_Homo sapiens_hsa003400.15821076
117Tyrosine metabolism_Homo sapiens_hsa003500.15179044
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13517072
119Cardiac muscle contraction_Homo sapiens_hsa042600.13098670
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12493827
121Allograft rejection_Homo sapiens_hsa053300.12130168
122Retinol metabolism_Homo sapiens_hsa008300.12012316
123Thyroid cancer_Homo sapiens_hsa052160.11022974
124Sulfur metabolism_Homo sapiens_hsa009200.10545609
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09894911

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