METTL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.70631694
2nuclear pore complex assembly (GO:0051292)5.69754970
3mitotic metaphase plate congression (GO:0007080)5.15281129
4metaphase plate congression (GO:0051310)4.49155227
5pore complex assembly (GO:0046931)4.41427821
6attachment of spindle microtubules to kinetochore (GO:0008608)4.35175449
7mitotic nuclear envelope disassembly (GO:0007077)4.33636902
8purine nucleobase biosynthetic process (GO:0009113)4.33109309
9kinetochore organization (GO:0051383)4.31271671
10mitotic sister chromatid cohesion (GO:0007064)4.27897883
11mitotic chromosome condensation (GO:0007076)4.24579638
12CENP-A containing nucleosome assembly (GO:0034080)4.23555029
13DNA replication checkpoint (GO:0000076)4.16529169
14chromatin remodeling at centromere (GO:0031055)4.16440030
15gonadal mesoderm development (GO:0007506)4.14536707
16regulation of DNA endoreduplication (GO:0032875)4.12997369
17establishment of chromosome localization (GO:0051303)4.10659077
18protein localization to kinetochore (GO:0034501)4.10449216
19nucleobase biosynthetic process (GO:0046112)4.10146555
20mitotic sister chromatid segregation (GO:0000070)4.07415730
21positive regulation of RNA splicing (GO:0033120)4.05263743
22nuclear envelope disassembly (GO:0051081)3.96840921
23membrane disassembly (GO:0030397)3.96840921
24meiotic chromosome segregation (GO:0045132)3.96775682
25regulation of spindle organization (GO:0090224)3.95479275
26DNA replication initiation (GO:0006270)3.94280581
27regulation of mitotic spindle organization (GO:0060236)3.90971639
28mitotic G2/M transition checkpoint (GO:0044818)3.87937603
29IMP biosynthetic process (GO:0006188)3.86061280
30negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.85481562
31DNA double-strand break processing (GO:0000729)3.84472258
32sister chromatid segregation (GO:0000819)3.77884084
33DNA replication-independent nucleosome assembly (GO:0006336)3.74374492
34DNA replication-independent nucleosome organization (GO:0034724)3.74374492
35DNA strand elongation involved in DNA replication (GO:0006271)3.70545317
36kinetochore assembly (GO:0051382)3.66756800
37synapsis (GO:0007129)3.65065823
38spindle checkpoint (GO:0031577)3.64435096
39histone exchange (GO:0043486)3.64048373
40DNA strand elongation (GO:0022616)3.60131625
41protein K6-linked ubiquitination (GO:0085020)3.59846316
42maturation of 5.8S rRNA (GO:0000460)3.58251846
43N-terminal protein amino acid acetylation (GO:0006474)3.52785412
44protein neddylation (GO:0045116)3.52572343
45telomere maintenance via recombination (GO:0000722)3.49435222
46protein localization to chromosome, centromeric region (GO:0071459)3.46683309
47mitotic recombination (GO:0006312)3.45352253
48sister chromatid cohesion (GO:0007062)3.44974548
49intra-S DNA damage checkpoint (GO:0031573)3.43718614
50mitotic G2 DNA damage checkpoint (GO:0007095)3.42554764
51proteasome assembly (GO:0043248)3.41947251
52telomere maintenance via semi-conservative replication (GO:0032201)3.41916888
53chromosome segregation (GO:0007059)3.41571640
54spindle assembly checkpoint (GO:0071173)3.40733694
55negative regulation of DNA recombination (GO:0045910)3.37845633
56mitotic spindle checkpoint (GO:0071174)3.36626059
57negative regulation of sister chromatid segregation (GO:0033046)3.36143761
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.36143761
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36143761
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36143761
61DNA duplex unwinding (GO:0032508)3.35899195
62DNA geometric change (GO:0032392)3.35049226
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33446071
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32335632
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31728428
66negative regulation of chromosome segregation (GO:0051985)3.30509066
67mitotic spindle assembly checkpoint (GO:0007094)3.30499768
68positive regulation of protein homodimerization activity (GO:0090073)3.25758045
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25348427
70mismatch repair (GO:0006298)3.24708327
71DNA ligation (GO:0006266)3.24547577
72negative regulation of DNA-dependent DNA replication (GO:2000104)3.24012537
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23648473
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23648473
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.23648473
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23486927
77IMP metabolic process (GO:0046040)3.22750592
78positive regulation of chromosome segregation (GO:0051984)3.21792269
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20883327
80regulation of mitotic sister chromatid separation (GO:0010965)3.20248220
81regulation of mitotic sister chromatid segregation (GO:0033047)3.20248220
82regulation of sister chromatid segregation (GO:0033045)3.20248220
83DNA synthesis involved in DNA repair (GO:0000731)3.19078236
84regulation of double-strand break repair via homologous recombination (GO:0010569)3.18800269
85regulation of mitotic spindle checkpoint (GO:1903504)3.18660269
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18660269
87DNA catabolic process, exonucleolytic (GO:0000738)3.14013065
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13176665
89regulation of chromosome segregation (GO:0051983)3.09338618
90DNA dealkylation (GO:0035510)3.09255864
91rRNA methylation (GO:0031167)3.07536205
92ribosome assembly (GO:0042255)3.07509526
93protein K11-linked ubiquitination (GO:0070979)3.05503697
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04338784
95DNA conformation change (GO:0071103)3.04086727
96telomere maintenance (GO:0000723)3.03873080
97ribosome biogenesis (GO:0042254)3.03349119
98protein localization to chromosome (GO:0034502)3.02654664
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02446023
100centriole replication (GO:0007099)3.00533335
101reciprocal meiotic recombination (GO:0007131)3.00232401
102reciprocal DNA recombination (GO:0035825)3.00232401
103telomere organization (GO:0032200)3.00209858
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.99750776
105DNA unwinding involved in DNA replication (GO:0006268)2.99139303
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98635238
107positive regulation of mRNA metabolic process (GO:1903313)2.98468360
108telomere maintenance via telomere lengthening (GO:0010833)2.96284882
109histone-serine phosphorylation (GO:0035404)2.94732415
110resolution of meiotic recombination intermediates (GO:0000712)2.94682943
111nuclear envelope organization (GO:0006998)2.94156617
112rRNA modification (GO:0000154)2.93600158
113deoxyribonucleotide biosynthetic process (GO:0009263)2.93537683
114ATP-dependent chromatin remodeling (GO:0043044)2.93521400
115regulation of centriole replication (GO:0046599)2.93499034
116cullin deneddylation (GO:0010388)2.93241281
117replication fork processing (GO:0031297)2.92631909
118DNA packaging (GO:0006323)2.90559360
119monoubiquitinated protein deubiquitination (GO:0035520)2.89763357
120DNA topological change (GO:0006265)2.89215170
121regulation of histone H3-K9 methylation (GO:0051570)2.87402716
122negative regulation of androgen receptor signaling pathway (GO:0060766)2.86632340
123positive regulation of mRNA processing (GO:0050685)2.85262350
124ribonucleoprotein complex disassembly (GO:0032988)2.84489153
125establishment of integrated proviral latency (GO:0075713)2.83608330
126DNA replication-dependent nucleosome assembly (GO:0006335)2.83081205
127DNA replication-dependent nucleosome organization (GO:0034723)2.83081205
128non-recombinational repair (GO:0000726)2.82930638
129double-strand break repair via nonhomologous end joining (GO:0006303)2.82930638
130histone H2A acetylation (GO:0043968)2.82119143
131microtubule depolymerization (GO:0007019)2.81519911
132mitotic cell cycle (GO:0000278)2.81004326
133negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.80655064
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80560411
135negative regulation of mitosis (GO:0045839)2.80310020
136transcription elongation from RNA polymerase I promoter (GO:0006362)2.78160304
137protein deneddylation (GO:0000338)2.76743830
138negative regulation of ligase activity (GO:0051352)2.74810784
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74810784
140positive regulation of ligase activity (GO:0051351)2.74024401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.88229176
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.58524484
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27086415
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.53984844
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.49435012
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.43217816
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99641069
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.90594189
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.83613411
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74296117
11AR_21909140_ChIP-Seq_LNCAP_Human2.66266253
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.62306615
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48011152
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45475792
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45210774
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.30805476
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.30110281
18TAF15_26573619_Chip-Seq_HEK293_Human2.25197032
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24718321
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.23663111
21ZNF274_21170338_ChIP-Seq_K562_Hela2.20793427
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20346183
23ELK1_19687146_ChIP-ChIP_HELA_Human2.18025471
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17016349
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16638648
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12276003
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09412190
28VDR_23849224_ChIP-Seq_CD4+_Human2.03810140
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02726408
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02152473
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00220146
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00200476
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00189171
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.97869074
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86496464
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82331416
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80862186
38FOXP3_21729870_ChIP-Seq_TREG_Human1.80315884
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78028265
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71612353
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71555022
42IGF1R_20145208_ChIP-Seq_DFB_Human1.69432578
43* CIITA_25753668_ChIP-Seq_RAJI_Human1.68715443
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66498436
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.62089338
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.61968318
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59738045
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58934944
49TTF2_22483619_ChIP-Seq_HELA_Human1.56890896
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53133421
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46086017
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41022317
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40454670
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39920573
55* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38563787
56EWS_26573619_Chip-Seq_HEK293_Human1.38499862
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37295700
58GABP_19822575_ChIP-Seq_HepG2_Human1.36617989
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.35630790
60XRN2_22483619_ChIP-Seq_HELA_Human1.34970869
61* DCP1A_22483619_ChIP-Seq_HELA_Human1.33706202
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33515469
63GBX2_23144817_ChIP-Seq_PC3_Human1.29020286
64* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28674878
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.28280691
66P300_19829295_ChIP-Seq_ESCs_Human1.27953594
67KDM5A_27292631_Chip-Seq_BREAST_Human1.26651368
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25750304
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18685203
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17646747
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16106019
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15449485
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14895238
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.14826408
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12650844
76GATA1_22025678_ChIP-Seq_K562_Human1.12262678
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.11063292
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10818758
79FUS_26573619_Chip-Seq_HEK293_Human1.10791833
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08744575
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06965302
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06052057
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06038043
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05428798
85CBP_20019798_ChIP-Seq_JUKART_Human1.05428798
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04403772
87ER_23166858_ChIP-Seq_MCF-7_Human1.03678081
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02761303
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00711071
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99478589
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99112446
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97994029
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97886735
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96840661
95MYC_18940864_ChIP-ChIP_HL60_Human0.96661051
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96361990
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.95948269
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95066455
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94046984
100* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93482398
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93013858
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91752197
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90836512
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.90747470
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90404373
106* TP53_22573176_ChIP-Seq_HFKS_Human0.89840359
107POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89748492
108* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89262746
109* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88346817
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87774044
111GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87320558
112TFEB_21752829_ChIP-Seq_HELA_Human0.86217745
113VDR_22108803_ChIP-Seq_LS180_Human0.86216323
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85771037
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85461235
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85084577
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83773533
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.83034730
119* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82915197
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82903408
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82641976
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.82139754
123STAT3_23295773_ChIP-Seq_U87_Human0.81923706
124IRF1_19129219_ChIP-ChIP_H3396_Human0.81873892
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80845839
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.77828949
127* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72599987
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.71782484
129MYC_22102868_ChIP-Seq_BL_Human0.67494525
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.66780693
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66482203
132* SOX17_20123909_ChIP-Seq_XEN_Mouse0.65706697
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.65056380
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.63841774
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63165586
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62389516
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.61792581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.66567777
2MP0000569_abnormal_digit_pigmentation4.46110816
3MP0010094_abnormal_chromosome_stability4.21048315
4MP0003111_abnormal_nucleus_morphology3.78261322
5MP0003693_abnormal_embryo_hatching3.70573776
6MP0003077_abnormal_cell_cycle3.69523001
7MP0008058_abnormal_DNA_repair3.58295988
8MP0003941_abnormal_skin_development3.19429480
9MP0008007_abnormal_cellular_replicative3.15702556
10MP0008877_abnormal_DNA_methylation3.13180621
11MP0004957_abnormal_blastocyst_morpholog2.97848529
12MP0002102_abnormal_ear_morphology2.80141367
13MP0005075_abnormal_melanosome_morpholog2.43674686
14MP0000015_abnormal_ear_pigmentation2.40911059
15MP0003123_paternal_imprinting2.36742020
16MP0002396_abnormal_hematopoietic_system2.26392376
17MP0008932_abnormal_embryonic_tissue2.22290173
18MP0000372_irregular_coat_pigmentation2.19974425
19MP0003880_abnormal_central_pattern2.02450084
20MP0006292_abnormal_olfactory_placode2.00685845
21MP0001529_abnormal_vocalization1.99941532
22MP0010307_abnormal_tumor_latency1.94807413
23MP0009053_abnormal_anal_canal1.89757034
24MP0009697_abnormal_copulation1.89585717
25MP0000350_abnormal_cell_proliferation1.87792451
26MP0006035_abnormal_mitochondrial_morpho1.86206913
27MP0003890_abnormal_embryonic-extraembry1.82898184
28MP0002210_abnormal_sex_determination1.82144823
29MP0001730_embryonic_growth_arrest1.76927589
30MP0003121_genomic_imprinting1.75967710
31MP0006054_spinal_hemorrhage1.75626551
32MP0002837_dystrophic_cardiac_calcinosis1.75469059
33MP0003786_premature_aging1.75388871
34MP0005380_embryogenesis_phenotype1.64791534
35MP0001672_abnormal_embryogenesis/_devel1.64791534
36MP0002928_abnormal_bile_duct1.62096620
37MP0001119_abnormal_female_reproductive1.59785825
38MP0003718_maternal_effect1.58625380
39MP0000647_abnormal_sebaceous_gland1.56451331
40MP0003984_embryonic_growth_retardation1.55172201
41MP0002095_abnormal_skin_pigmentation1.54711539
42MP0001697_abnormal_embryo_size1.51609791
43MP0001929_abnormal_gametogenesis1.50202490
44MP0000427_abnormal_hair_cycle1.48005767
45MP0001145_abnormal_male_reproductive1.47567525
46MP0003806_abnormal_nucleotide_metabolis1.46285352
47MP0003115_abnormal_respiratory_system1.46053527
48MP0002160_abnormal_reproductive_system1.45071851
49MP0004808_abnormal_hematopoietic_stem1.44205395
50MP0003950_abnormal_plasma_membrane1.43887612
51MP0000653_abnormal_sex_gland1.42431405
52MP0002088_abnormal_embryonic_growth/wei1.41074622
53MP0000490_abnormal_crypts_of1.40069846
54MP0003943_abnormal_hepatobiliary_system1.40061237
55MP0005408_hypopigmentation1.37237242
56MP0005174_abnormal_tail_pigmentation1.36705481
57MP0000358_abnormal_cell_content/1.34795282
58MP0001545_abnormal_hematopoietic_system1.31821183
59MP0005397_hematopoietic_system_phenotyp1.31821183
60MP0002086_abnormal_extraembryonic_tissu1.31441714
61MP0004142_abnormal_muscle_tone1.29398174
62MP0006036_abnormal_mitochondrial_physio1.27996102
63MP0000313_abnormal_cell_death1.22918833
64MP0003763_abnormal_thymus_physiology1.22429011
65MP0003787_abnormal_imprinting1.20694942
66MP0004147_increased_porphyrin_level1.20619511
67MP0002085_abnormal_embryonic_tissue1.19054509
68MP0000566_synostosis1.18769565
69MP0002080_prenatal_lethality1.18626446
70MP0005389_reproductive_system_phenotype1.17695832
71MP0005310_abnormal_salivary_gland1.17363973
72MP0003567_abnormal_fetal_cardiomyocyte1.15502839
73MP0004197_abnormal_fetal_growth/weight/1.14362173
74MP0002736_abnormal_nociception_after1.08413614
75MP0010352_gastrointestinal_tract_polyps1.06655016
76MP0001879_abnormal_lymphatic_vessel1.03775177
77MP0002084_abnormal_developmental_patter1.02794955
78MP0002019_abnormal_tumor_incidence1.02780967
79MP0001727_abnormal_embryo_implantation1.01367728
80MP0003942_abnormal_urinary_system1.01224916
81MP0005379_endocrine/exocrine_gland_phen1.00046087
82MP0002163_abnormal_gland_morphology0.96346675
83MP0000428_abnormal_craniofacial_morphol0.96205258
84MP0000371_diluted_coat_color0.95275562
85MP0008260_abnormal_autophagy0.95036474
86MP0005499_abnormal_olfactory_system0.92746375
87MP0005394_taste/olfaction_phenotype0.92746375
88MP0002398_abnormal_bone_marrow0.91838006
89MP0000689_abnormal_spleen_morphology0.91197907
90MP0009333_abnormal_splenocyte_physiolog0.91108473
91MP0003698_abnormal_male_reproductive0.90815769
92MP0003221_abnormal_cardiomyocyte_apopto0.90722785
93MP0001915_intracranial_hemorrhage0.88375695
94MP0001984_abnormal_olfaction0.88138057
95MP0008789_abnormal_olfactory_epithelium0.87539555
96MP0001986_abnormal_taste_sensitivity0.87245705
97MP0000432_abnormal_head_morphology0.86794806
98MP0002132_abnormal_respiratory_system0.86435047
99MP0001764_abnormal_homeostasis0.86158246
100MP0005503_abnormal_tendon_morphology0.85658662
101MP0008995_early_reproductive_senescence0.85254243
102MP0002653_abnormal_ependyma_morphology0.85244237
103MP0008438_abnormal_cutaneous_collagen0.84929847
104MP0003724_increased_susceptibility_to0.84841334
105MP0003385_abnormal_body_wall0.84164389
106MP0001324_abnormal_eye_pigmentation0.83375489
107MP0000703_abnormal_thymus_morphology0.83256105
108MP0002722_abnormal_immune_system0.83210467
109MP0003699_abnormal_female_reproductive0.82062472
110MP0001175_abnormal_lung_morphology0.81302647
111MP0003755_abnormal_palate_morphology0.79220028
112MP0002638_abnormal_pupillary_reflex0.79041864
113MP0004215_abnormal_myocardial_fiber0.77124593
114MP0005621_abnormal_cell_physiology0.76959568
115MP0003656_abnormal_erythrocyte_physiolo0.76845280
116MP0003937_abnormal_limbs/digits/tail_de0.76375855
117MP0005266_abnormal_metabolism0.75396737
118MP0003186_abnormal_redox_activity0.74667825
119MP0001177_atelectasis0.74041754
120MP0002233_abnormal_nose_morphology0.73909856
121MP0005384_cellular_phenotype0.73318018
122MP0000516_abnormal_urinary_system0.72671614
123MP0005367_renal/urinary_system_phenotyp0.72671614
124MP0002161_abnormal_fertility/fecundity0.72316127
125MP0009703_decreased_birth_body0.71867526
126MP0003936_abnormal_reproductive_system0.70904514
127MP0006276_abnormal_autonomic_nervous0.70633021
128MP0005464_abnormal_platelet_physiology0.70609571
129MP0009672_abnormal_birth_weight0.68805582
130MP0001293_anophthalmia0.68200162
131MP0005671_abnormal_response_to0.67269125
132MP0005187_abnormal_penis_morphology0.66982708
133MP0005084_abnormal_gallbladder_morpholo0.66944361
134MP0009250_abnormal_appendicular_skeleto0.66846399
135MP0001919_abnormal_reproductive_system0.65828066
136MP0004264_abnormal_extraembryonic_tissu0.65568827
137MP0002109_abnormal_limb_morphology0.63648081
138MP0005647_abnormal_sex_gland0.63633136
139MP0009765_abnormal_xenobiotic_induced0.63489508
140MP0002009_preneoplasia0.63209553
141MP0002751_abnormal_autonomic_nervous0.61833870
142MP0005248_abnormal_Harderian_gland0.59667980
143MP0001905_abnormal_dopamine_level0.58598688

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.32156947
2Impulsivity (HP:0100710)4.78401637
3Abnormal hair whorl (HP:0010721)4.47269749
4Chromsome breakage (HP:0040012)4.35439922
5Abnormality of the fingertips (HP:0001211)4.22684233
6Abnormality of the nasal septum (HP:0000419)3.94286128
7Abnormality of incisor morphology (HP:0011063)3.66797256
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61879010
9Abnormality of cochlea (HP:0000375)3.40460504
10Papillary thyroid carcinoma (HP:0002895)3.26656463
11Ectopic kidney (HP:0000086)3.17278615
12Cortical dysplasia (HP:0002539)3.12974603
13Capillary hemangiomas (HP:0005306)3.12616170
14Abnormality of the aortic arch (HP:0012303)3.09352418
15Abnormal spermatogenesis (HP:0008669)3.05741202
16Breast hypoplasia (HP:0003187)3.01381113
17Diastasis recti (HP:0001540)3.01331894
18Short middle phalanx of the 5th finger (HP:0004220)3.00790779
19Increased hepatocellular lipid droplets (HP:0006565)2.98008355
20Patellar aplasia (HP:0006443)2.97948659
21Shawl scrotum (HP:0000049)2.96174032
22Abnormality of chromosome stability (HP:0003220)2.94792892
23Abnormality of the anterior horn cell (HP:0006802)2.93798368
24Degeneration of anterior horn cells (HP:0002398)2.93798368
25Abnormal lung lobation (HP:0002101)2.89662510
26Abnormality of the columella (HP:0009929)2.78461889
27Pancreatic cysts (HP:0001737)2.78072771
28Azoospermia (HP:0000027)2.75139567
29Clubbing of toes (HP:0100760)2.73719775
30Aplasia/Hypoplasia of the patella (HP:0006498)2.69871807
31Abnormality of the incisor (HP:0000676)2.68848962
32Abnormality of the phalanges of the hallux (HP:0010057)2.67628454
33Embryonal renal neoplasm (HP:0011794)2.65126514
34Nephroblastoma (Wilms tumor) (HP:0002667)2.61240433
35Long eyelashes (HP:0000527)2.57819778
36Congenital primary aphakia (HP:0007707)2.57532353
37Lipid accumulation in hepatocytes (HP:0006561)2.49025014
38Abnormality of the duodenum (HP:0002246)2.48325436
39Medial flaring of the eyebrow (HP:0010747)2.46930939
40Aplastic anemia (HP:0001915)2.46847533
41Deep philtrum (HP:0002002)2.46555517
42Gait imbalance (HP:0002141)2.45775874
43Nephrogenic diabetes insipidus (HP:0009806)2.43930185
44Depressed nasal tip (HP:0000437)2.39504050
45Progressive inability to walk (HP:0002505)2.32425695
46Acute myeloid leukemia (HP:0004808)2.31343728
47Abnormality of the right ventricle (HP:0001707)2.30107099
48Hypoplastic iliac wings (HP:0002866)2.29747946
49Morphological abnormality of the inner ear (HP:0011390)2.27646444
50Myelodysplasia (HP:0002863)2.25440515
51Hypoplastic left heart (HP:0004383)2.22292302
52Meckel diverticulum (HP:0002245)2.21594238
53Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.19204656
54Thyroid carcinoma (HP:0002890)2.18630545
55Abnormality of the preputium (HP:0100587)2.17980388
56Abnormality of the parietal bone (HP:0002696)2.17632003
57Oral leukoplakia (HP:0002745)2.14221841
58Abnormality of male internal genitalia (HP:0000022)2.12885561
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.11814583
60Renal cortical cysts (HP:0000803)2.10410155
61Glioma (HP:0009733)2.08761238
62Astigmatism (HP:0000483)2.08680874
63Sloping forehead (HP:0000340)2.08588728
64Abnormality of the septum pellucidum (HP:0007375)2.07883351
65Abnormality of the prostate (HP:0008775)2.06689016
66Abnormality of the ileum (HP:0001549)2.06521314
67Lip pit (HP:0100267)2.05319361
68Small intestinal stenosis (HP:0012848)2.04489724
69Duodenal stenosis (HP:0100867)2.04489724
70Truncal obesity (HP:0001956)2.03875050
71Progressive macrocephaly (HP:0004481)2.01075181
72Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00979585
73Amyotrophic lateral sclerosis (HP:0007354)2.00194586
74Poikilocytosis (HP:0004447)2.00138375
75Abnormality of the musculature of the pelvis (HP:0001469)1.99418188
76Abnormality of the hip-girdle musculature (HP:0001445)1.99418188
77Supernumerary spleens (HP:0009799)1.97453807
78Pulmonary fibrosis (HP:0002206)1.97453294
79Rhabdomyosarcoma (HP:0002859)1.97452779
80Abnormality of the labia minora (HP:0012880)1.96393829
81Volvulus (HP:0002580)1.96009854
82Increased nuchal translucency (HP:0010880)1.95642859
83Increased CSF lactate (HP:0002490)1.95035091
84Long foot (HP:0001833)1.94492417
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.93487744
86Genital tract atresia (HP:0001827)1.93161573
87Methylmalonic acidemia (HP:0002912)1.92850511
88Vaginal atresia (HP:0000148)1.90751670
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.90539073
90Abnormality of methionine metabolism (HP:0010901)1.89721163
91Obstructive sleep apnea (HP:0002870)1.89113110
92Cafe-au-lait spot (HP:0000957)1.88700549
93Renal Fanconi syndrome (HP:0001994)1.88695243
94Albinism (HP:0001022)1.88437995
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.88238514
96Colon cancer (HP:0003003)1.87377993
97Hypochromic microcytic anemia (HP:0004840)1.86509814
98Abnormality of DNA repair (HP:0003254)1.86504898
99Acute necrotizing encephalopathy (HP:0006965)1.86443924
100Nephronophthisis (HP:0000090)1.86400293
101Abnormality of renal resorption (HP:0011038)1.86199727
102Fair hair (HP:0002286)1.84798573
103Pancreatic fibrosis (HP:0100732)1.84379259
104Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84281752
105Respiratory difficulties (HP:0002880)1.84028028
106CNS hypomyelination (HP:0003429)1.83656990
107Absent thumb (HP:0009777)1.83621907
108Aseptic necrosis (HP:0010885)1.83127481
109Medulloblastoma (HP:0002885)1.83037137
110Abnormal auditory evoked potentials (HP:0006958)1.82185520
111Dislocated radial head (HP:0003083)1.81854982
112Neoplasm of the adrenal cortex (HP:0100641)1.81458534
113Type 2 muscle fiber atrophy (HP:0003554)1.80751392
114Absent septum pellucidum (HP:0001331)1.80681896
115Hypobetalipoproteinemia (HP:0003563)1.80534278
116Duplicated collecting system (HP:0000081)1.80443898
117Bone marrow hypocellularity (HP:0005528)1.80387841
118Poor coordination (HP:0002370)1.80001830
119True hermaphroditism (HP:0010459)1.79921769
120Oligodactyly (hands) (HP:0001180)1.79142287
121Dandy-Walker malformation (HP:0001305)1.77977151
122Neoplasm of the adrenal gland (HP:0100631)1.77971463
123Septo-optic dysplasia (HP:0100842)1.77626621
124Tongue fasciculations (HP:0001308)1.77619266
125Anencephaly (HP:0002323)1.76906204
126Abnormality of the renal collecting system (HP:0004742)1.76716510
127Acute encephalopathy (HP:0006846)1.75830811
128Nasolacrimal duct obstruction (HP:0000579)1.74263439
129Optic nerve coloboma (HP:0000588)1.74006791
130Postaxial foot polydactyly (HP:0001830)1.73596953
131Eosinophilia (HP:0001880)1.73404599
132Abnormality of the carotid arteries (HP:0005344)1.73307017
133Abnormality of lateral ventricle (HP:0030047)1.72655233
134Neoplasm of the colon (HP:0100273)1.72065859
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.72007273
136Absent radius (HP:0003974)1.71863136
137Median cleft lip (HP:0000161)1.71564941
138Absent forearm bone (HP:0003953)1.71284466
139Aplasia involving forearm bones (HP:0009822)1.71284466
140Abnormality of the phalanges of the 5th finger (HP:0004213)1.71154756
141Drooling (HP:0002307)1.70897904
142Acanthocytosis (HP:0001927)1.70434215
143Granulocytopenia (HP:0001913)1.69919063
144Hypoplastic heart (HP:0001961)1.68702105
145Molar tooth sign on MRI (HP:0002419)1.68699826
146Abnormality of midbrain morphology (HP:0002418)1.68699826
147Optic nerve hypoplasia (HP:0000609)1.68399693
148Aqueductal stenosis (HP:0002410)1.68091203
149Growth hormone deficiency (HP:0000824)1.67608310
150Oligohydramnios (HP:0001562)1.67602250
151Arteriovenous malformation (HP:0100026)1.67432608
152Limb hypertonia (HP:0002509)1.67092196
153Intestinal fistula (HP:0100819)1.66895157
154Premature graying of hair (HP:0002216)1.66840427
155Breast carcinoma (HP:0003002)1.66500914
156Pancreatic islet-cell hyperplasia (HP:0004510)1.65785660
157Broad foot (HP:0001769)1.65132435
158Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65050516
159Short 4th metacarpal (HP:0010044)1.65050516
160Pelvic girdle muscle weakness (HP:0003749)1.64727580
161Excessive salivation (HP:0003781)1.64544604
162Cutaneous melanoma (HP:0012056)1.64504390
163Horseshoe kidney (HP:0000085)1.64430869
164Papilledema (HP:0001085)1.64295637
165Broad thumb (HP:0011304)1.63772634
166Convex nasal ridge (HP:0000444)1.63725937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.86096176
2ZAK3.78258432
3TRIM283.30345769
4SRPK13.28385106
5ACVR1B2.79242824
6BUB12.76449284
7WEE12.57549834
8BRSK22.57092819
9BCR2.54161282
10EIF2AK12.44901034
11PLK32.42015069
12NEK12.41458782
13NEK22.31521367
14WNK32.24131510
15VRK12.18200354
16TNIK2.15428696
17MKNK12.14653613
18PLK42.13458465
19MAP4K22.04406170
20STK162.00146259
21ERBB32.00081846
22PBK1.89798677
23LMTK21.88280480
24TTK1.82117072
25TSSK61.79652803
26MKNK21.79226531
27SGK21.78645116
28STK38L1.68862279
29BRSK11.67835047
30PLK11.62882597
31PASK1.61818466
32ATR1.53618381
33AKT31.48808218
34CCNB11.47661407
35FRK1.39119848
36AURKB1.38613417
37STK41.38005248
38EIF2AK31.34274095
39MAP3K61.33085569
40STK101.30541963
41SGK31.30514232
42MARK31.28753631
43PDK41.26917396
44PDK31.26917396
45STK31.24269889
46CHEK11.20412942
47TXK1.17823124
48CHEK21.16396959
49ATM1.12566895
50CDK121.10539295
51CHUK1.08820524
52OBSCN1.06933131
53NTRK31.03184620
54MAP3K121.02416172
55MAPK130.98658031
56TRPM70.97957238
57CLK10.95606537
58PDGFRA0.95576330
59JAK30.95191575
60ERBB40.93201926
61PIM10.91146398
62YES10.88819466
63CDK20.87804472
64SIK30.87388886
65STK240.87341411
66FLT30.87136282
67EIF2AK20.85742035
68MAP3K140.85258796
69RPS6KA40.80543184
70CASK0.79622987
71STK390.78012122
72PLK20.77974399
73NEK60.77858046
74CDK70.77044005
75CDK10.74836925
76DYRK30.74335375
77MAP3K80.73153633
78CSNK1G30.71661020
79TEC0.71441986
80CAMK40.71300044
81OXSR10.69918554
82RPS6KB10.67682540
83MAP3K100.66737768
84CDK30.66718305
85RAF10.65729882
86SGK2230.65228604
87SGK4940.65228604
88KSR10.64610650
89PRKG20.63698260
90TLK10.62619079
91FGR0.61961265
92NEK90.61587995
93BRD40.60941722
94MELK0.60319459
95TESK10.59812335
96PDK20.59368490
97AURKA0.59278670
98CSNK1G10.58141580
99CDK60.57641578
100LATS10.54910317
101RPS6KB20.54240986
102CDK80.53404034
103MAP3K40.52181396
104GRK60.52121612
105CSNK2A10.51430861
106WNK40.48821083
107IRAK40.48469184
108NUAK10.47245893
109MST40.46221012
110BRAF0.45674574
111FGFR20.45539357
112CSNK1G20.45529505
113IKBKB0.44975538
114AKT10.44182602
115MAP2K30.43826427
116BTK0.43198016
117PINK10.42575335
118FGFR30.42440063
119ZAP700.40069729
120PAK30.39149150
121CDK190.38815603
122TGFBR10.37634283
123MAP2K60.37507566
124PIK3CA0.37046046
125CSNK1A1L0.35917082
126PTK2B0.33600532
127CSNK2A20.33060461
128DYRK20.32751794
129CAMKK20.32481609
130PDGFRB0.32034758
131BMPR20.31613235
132LIMK10.31090117
133MINK10.30940473
134MAPK140.29791867
135CDK40.27879980
136GSK3B0.27435892
137BMPR1B0.26658000
138TAOK30.25777535
139MUSK0.25615149
140SIK20.24085581
141LYN0.23582030
142ILK0.23246341
143EGFR0.22722498
144MAP3K50.22660441

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27615838
2Mismatch repair_Homo sapiens_hsa034303.79077197
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61621654
4Cell cycle_Homo sapiens_hsa041103.53419219
5Non-homologous end-joining_Homo sapiens_hsa034503.43241057
6Base excision repair_Homo sapiens_hsa034103.40166063
7RNA transport_Homo sapiens_hsa030133.30931285
8Spliceosome_Homo sapiens_hsa030403.06285962
9Homologous recombination_Homo sapiens_hsa034403.02405401
10RNA polymerase_Homo sapiens_hsa030202.71140245
11One carbon pool by folate_Homo sapiens_hsa006702.67779999
12RNA degradation_Homo sapiens_hsa030182.60998539
13Fanconi anemia pathway_Homo sapiens_hsa034602.52162804
14Nucleotide excision repair_Homo sapiens_hsa034202.35226690
15Basal transcription factors_Homo sapiens_hsa030222.26313034
16mRNA surveillance pathway_Homo sapiens_hsa030152.08033603
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.07191334
18Proteasome_Homo sapiens_hsa030502.05209412
19Pyrimidine metabolism_Homo sapiens_hsa002402.03815113
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02129890
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00427252
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.99896308
23p53 signaling pathway_Homo sapiens_hsa041151.75573885
24Steroid biosynthesis_Homo sapiens_hsa001001.71088658
25Propanoate metabolism_Homo sapiens_hsa006401.44711172
26Purine metabolism_Homo sapiens_hsa002301.35457539
27Regulation of autophagy_Homo sapiens_hsa041401.28512908
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27736188
29Epstein-Barr virus infection_Homo sapiens_hsa051691.27384551
30Systemic lupus erythematosus_Homo sapiens_hsa053221.26768182
31Herpes simplex infection_Homo sapiens_hsa051681.26600307
32Parkinsons disease_Homo sapiens_hsa050121.21703679
33TGF-beta signaling pathway_Homo sapiens_hsa043501.19567252
34Viral carcinogenesis_Homo sapiens_hsa052031.16559680
35MicroRNAs in cancer_Homo sapiens_hsa052061.11076494
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10635895
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10352722
38Fatty acid elongation_Homo sapiens_hsa000621.09974976
39Oxidative phosphorylation_Homo sapiens_hsa001901.05943375
40Oocyte meiosis_Homo sapiens_hsa041140.99262112
41Selenocompound metabolism_Homo sapiens_hsa004500.97652932
42HTLV-I infection_Homo sapiens_hsa051660.90820849
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88108687
44Huntingtons disease_Homo sapiens_hsa050160.87654679
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84662993
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82801301
47Folate biosynthesis_Homo sapiens_hsa007900.79581700
48Vitamin B6 metabolism_Homo sapiens_hsa007500.78771706
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78005541
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77739071
51Dorso-ventral axis formation_Homo sapiens_hsa043200.77009671
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.76997165
53Thyroid cancer_Homo sapiens_hsa052160.75973977
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70075705
55Influenza A_Homo sapiens_hsa051640.69045290
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68818800
57Prostate cancer_Homo sapiens_hsa052150.66891482
58Collecting duct acid secretion_Homo sapiens_hsa049660.66877626
59Notch signaling pathway_Homo sapiens_hsa043300.66462150
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66075160
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.65903890
62Antigen processing and presentation_Homo sapiens_hsa046120.65653775
63Measles_Homo sapiens_hsa051620.64891292
64Nicotine addiction_Homo sapiens_hsa050330.64765955
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.64111116
66Legionellosis_Homo sapiens_hsa051340.63130876
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61988788
68Primary immunodeficiency_Homo sapiens_hsa053400.59872991
69Adherens junction_Homo sapiens_hsa045200.59468347
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59437650
71Taste transduction_Homo sapiens_hsa047420.58779528
72Pyruvate metabolism_Homo sapiens_hsa006200.57306473
73Hepatitis B_Homo sapiens_hsa051610.56516570
74Pentose phosphate pathway_Homo sapiens_hsa000300.56403778
75Glutathione metabolism_Homo sapiens_hsa004800.56323896
76Phototransduction_Homo sapiens_hsa047440.56297067
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53479529
78Shigellosis_Homo sapiens_hsa051310.52733265
79Small cell lung cancer_Homo sapiens_hsa052220.52437973
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51981436
81Olfactory transduction_Homo sapiens_hsa047400.51381856
82Biosynthesis of amino acids_Homo sapiens_hsa012300.50777839
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48433902
84Protein export_Homo sapiens_hsa030600.47505167
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47311561
86Arachidonic acid metabolism_Homo sapiens_hsa005900.47084922
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46423612
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46240236
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45850460
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44052464
91Apoptosis_Homo sapiens_hsa042100.43666592
92Colorectal cancer_Homo sapiens_hsa052100.42588779
93Endometrial cancer_Homo sapiens_hsa052130.42518467
94Sulfur metabolism_Homo sapiens_hsa009200.42284987
95Hippo signaling pathway_Homo sapiens_hsa043900.41985561
96Alzheimers disease_Homo sapiens_hsa050100.41451955
97FoxO signaling pathway_Homo sapiens_hsa040680.40522645
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.40041059
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39979312
100Butanoate metabolism_Homo sapiens_hsa006500.39251347
101Ribosome_Homo sapiens_hsa030100.35621709
102Lysine degradation_Homo sapiens_hsa003100.35091612
103Allograft rejection_Homo sapiens_hsa053300.35063537
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34936726
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34434031
106Metabolic pathways_Homo sapiens_hsa011000.32752745
107Basal cell carcinoma_Homo sapiens_hsa052170.32075541
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31380753
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29498083
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29119500
111Fatty acid metabolism_Homo sapiens_hsa012120.28683650
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.28612148
113Peroxisome_Homo sapiens_hsa041460.28267273
114Melanoma_Homo sapiens_hsa052180.28255032
115Alcoholism_Homo sapiens_hsa050340.28142619
116Platelet activation_Homo sapiens_hsa046110.27295254
117Gap junction_Homo sapiens_hsa045400.27184880
118Renal cell carcinoma_Homo sapiens_hsa052110.26868103
119Hematopoietic cell lineage_Homo sapiens_hsa046400.26591779
120HIF-1 signaling pathway_Homo sapiens_hsa040660.26122331
121Pathways in cancer_Homo sapiens_hsa052000.25824143
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24058012
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23301932
124T cell receptor signaling pathway_Homo sapiens_hsa046600.23210610
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22647034
126N-Glycan biosynthesis_Homo sapiens_hsa005100.21853511
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21385746
128Dopaminergic synapse_Homo sapiens_hsa047280.19663558
129Wnt signaling pathway_Homo sapiens_hsa043100.19156527
130Pancreatic cancer_Homo sapiens_hsa052120.17942117
131Carbon metabolism_Homo sapiens_hsa012000.17377677
132Long-term depression_Homo sapiens_hsa047300.17307599
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17005858
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.15551308
135Leishmaniasis_Homo sapiens_hsa051400.15152272
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.14779807
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14637606
138Inositol phosphate metabolism_Homo sapiens_hsa005620.13726111
139Autoimmune thyroid disease_Homo sapiens_hsa053200.13707968
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11407914
141Viral myocarditis_Homo sapiens_hsa054160.10785217
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10427778
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10266206
144Asthma_Homo sapiens_hsa053100.09926919

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