METTL2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.71549153
2mitochondrial respiratory chain complex I assembly (GO:0032981)4.20734629
3NADH dehydrogenase complex assembly (GO:0010257)4.20734629
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20734629
5pseudouridine synthesis (GO:0001522)4.04016419
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03187115
7protein complex biogenesis (GO:0070271)4.03177164
8mitochondrial respiratory chain complex assembly (GO:0033108)3.93401712
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87983669
10ATP synthesis coupled proton transport (GO:0015986)3.87983669
11DNA deamination (GO:0045006)3.85233699
12water-soluble vitamin biosynthetic process (GO:0042364)3.85040528
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.72039303
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59989095
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59989095
16maturation of 5.8S rRNA (GO:0000460)3.57416051
17chaperone-mediated protein transport (GO:0072321)3.44742594
18respiratory chain complex IV assembly (GO:0008535)3.38614232
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33676707
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30886682
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24994276
22DNA replication checkpoint (GO:0000076)3.23126056
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20654701
24replication fork processing (GO:0031297)3.19152347
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.17730406
26protein-cofactor linkage (GO:0018065)3.13280764
27chromatin remodeling at centromere (GO:0031055)3.09077152
28protein neddylation (GO:0045116)3.01496811
29preassembly of GPI anchor in ER membrane (GO:0016254)2.99569848
30* tRNA processing (GO:0008033)2.99287538
31mitochondrial RNA metabolic process (GO:0000959)2.97928803
32proteasome assembly (GO:0043248)2.97267634
33DNA double-strand break processing (GO:0000729)2.93938870
34cytochrome complex assembly (GO:0017004)2.93830792
35CENP-A containing nucleosome assembly (GO:0034080)2.91758091
36cullin deneddylation (GO:0010388)2.90904470
37termination of RNA polymerase III transcription (GO:0006386)2.88704672
38transcription elongation from RNA polymerase III promoter (GO:0006385)2.88704672
39protein deneddylation (GO:0000338)2.88475090
40rRNA modification (GO:0000154)2.84171876
41peptidyl-histidine modification (GO:0018202)2.83294069
42negative regulation of DNA-dependent DNA replication (GO:2000104)2.78406343
43electron transport chain (GO:0022900)2.75634155
44negative regulation of telomere maintenance (GO:0032205)2.75349354
45kynurenine metabolic process (GO:0070189)2.73827917
46L-methionine salvage (GO:0071267)2.72868816
47L-methionine biosynthetic process (GO:0071265)2.72868816
48amino acid salvage (GO:0043102)2.72868816
49respiratory electron transport chain (GO:0022904)2.71198983
50mannosylation (GO:0097502)2.65978639
51* tRNA metabolic process (GO:0006399)2.63658594
52negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63576050
53protein polyglutamylation (GO:0018095)2.63339399
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62271399
55ubiquinone metabolic process (GO:0006743)2.59557985
56ubiquinone biosynthetic process (GO:0006744)2.58447002
57DNA damage response, detection of DNA damage (GO:0042769)2.58150431
58recombinational repair (GO:0000725)2.57425756
59intracellular protein transmembrane import (GO:0044743)2.56699802
60regulation of mesoderm development (GO:2000380)2.56658767
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56648145
62regulation of mitotic spindle checkpoint (GO:1903504)2.56648145
63protein K6-linked ubiquitination (GO:0085020)2.55872341
64cellular component biogenesis (GO:0044085)2.55260081
65response to pheromone (GO:0019236)2.53568147
66double-strand break repair via homologous recombination (GO:0000724)2.53361623
67ribosomal small subunit assembly (GO:0000028)2.52536697
68histone exchange (GO:0043486)2.52493565
69cell proliferation in forebrain (GO:0021846)2.51764731
70reciprocal DNA recombination (GO:0035825)2.51474464
71reciprocal meiotic recombination (GO:0007131)2.51474464
72GPI anchor metabolic process (GO:0006505)2.50091446
73rRNA processing (GO:0006364)2.48970133
74kidney morphogenesis (GO:0060993)2.47668140
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47579526
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.47579526
77regulation of DNA endoreduplication (GO:0032875)2.47107404
78rRNA metabolic process (GO:0016072)2.45895856
79nonmotile primary cilium assembly (GO:0035058)2.45317929
80DNA catabolic process, exonucleolytic (GO:0000738)2.44386699
81GTP biosynthetic process (GO:0006183)2.42759230
82* ncRNA processing (GO:0034470)2.42123311
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41391115
84rRNA methylation (GO:0031167)2.40805329
85* ncRNA metabolic process (GO:0034660)2.40789115
86transcription elongation from RNA polymerase I promoter (GO:0006362)2.39341780
87DNA replication-dependent nucleosome assembly (GO:0006335)2.38231916
88DNA replication-dependent nucleosome organization (GO:0034723)2.38231916
89somite development (GO:0061053)2.38085867
90platelet dense granule organization (GO:0060155)2.37215304
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37100742
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.37089197
93DNA-dependent DNA replication (GO:0006261)2.36713948
94ribosomal large subunit biogenesis (GO:0042273)2.36264427
95maturation of SSU-rRNA (GO:0030490)2.36062521
96resolution of meiotic recombination intermediates (GO:0000712)2.35552192
97regulation of centriole replication (GO:0046599)2.35378706
98protein targeting to mitochondrion (GO:0006626)2.35358053
99* tRNA modification (GO:0006400)2.35156901
100spliceosomal snRNP assembly (GO:0000387)2.34958933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05229494
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.99101054
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.50133036
4* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34917861
5ZNF274_21170338_ChIP-Seq_K562_Hela3.25899826
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87960210
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75679856
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74377203
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.66443648
10VDR_22108803_ChIP-Seq_LS180_Human2.45096733
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37153313
12ELK1_19687146_ChIP-ChIP_HELA_Human2.24545575
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.21564070
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19463984
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17316325
16MYC_18940864_ChIP-ChIP_HL60_Human2.16735202
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12927942
18EWS_26573619_Chip-Seq_HEK293_Human2.12393932
19VDR_23849224_ChIP-Seq_CD4+_Human2.11466523
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.10635770
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.08432667
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00866312
23IRF1_19129219_ChIP-ChIP_H3396_Human1.96755001
24FUS_26573619_Chip-Seq_HEK293_Human1.96516326
25E2F7_22180533_ChIP-Seq_HELA_Human1.90051134
26IGF1R_20145208_ChIP-Seq_DFB_Human1.86513844
27FOXP3_21729870_ChIP-Seq_TREG_Human1.81937079
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81686422
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.77517742
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75880805
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66699344
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66256287
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56792861
34GBX2_23144817_ChIP-Seq_PC3_Human1.53584790
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53542986
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53184580
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51316037
38* GABP_19822575_ChIP-Seq_HepG2_Human1.51046164
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50352854
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49180812
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48586820
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47407614
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46238371
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46039785
45TTF2_22483619_ChIP-Seq_HELA_Human1.44800105
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41570861
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40936565
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40843224
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40301894
50EZH2_22144423_ChIP-Seq_EOC_Human1.39945850
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.38619215
52TP53_22573176_ChIP-Seq_HFKS_Human1.38451371
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38200965
54TAF15_26573619_Chip-Seq_HEK293_Human1.33983381
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33885187
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33217165
57P300_19829295_ChIP-Seq_ESCs_Human1.32071304
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29575778
59ER_23166858_ChIP-Seq_MCF-7_Human1.29135393
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28623957
61XRN2_22483619_ChIP-Seq_HELA_Human1.25176512
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.25114505
63* DCP1A_22483619_ChIP-Seq_HELA_Human1.24720278
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.24356819
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21378293
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.21106999
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.20623635
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18800451
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18097177
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.14336840
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13570632
72RNF2_27304074_Chip-Seq_NSC_Mouse1.10176710
73* E2F1_21310950_ChIP-Seq_MCF-7_Human1.03277712
74* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02249326
75* FOXA1_25329375_ChIP-Seq_VCAP_Human1.02249326
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99410683
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99271871
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98859737
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98642573
80KDM5A_27292631_Chip-Seq_BREAST_Human0.98142848
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98052070
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97742767
83HOXB7_26014856_ChIP-Seq_BT474_Human0.97507842
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97059345
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95266905
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95152437
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93038125
88NCOR_22424771_ChIP-Seq_293T_Human0.92719080
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92506858
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89899060
91CBP_20019798_ChIP-Seq_JUKART_Human0.89044589
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89044589
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.85974479
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85804947
95NANOG_19829295_ChIP-Seq_ESCs_Human0.84396745
96SOX2_19829295_ChIP-Seq_ESCs_Human0.84396745
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84382314
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84222230
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84122143
100AR_20517297_ChIP-Seq_VCAP_Human0.82795885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.15056268
2MP0002102_abnormal_ear_morphology2.78574248
3MP0003693_abnormal_embryo_hatching2.43124998
4MP0008877_abnormal_DNA_methylation2.41474012
5MP0003646_muscle_fatigue2.33747878
6MP0008058_abnormal_DNA_repair2.21205947
7MP0004147_increased_porphyrin_level2.17001433
8MP0001529_abnormal_vocalization2.15347382
9MP0002938_white_spotting2.13745059
10MP0006072_abnormal_retinal_apoptosis1.99435369
11MP0002638_abnormal_pupillary_reflex1.94626287
12MP0004133_heterotaxia1.82561045
13MP0002837_dystrophic_cardiac_calcinosis1.79400189
14MP0010094_abnormal_chromosome_stability1.75681817
15MP0005551_abnormal_eye_electrophysiolog1.73181316
16MP0003890_abnormal_embryonic-extraembry1.68842667
17MP0001293_anophthalmia1.68715759
18MP0003011_delayed_dark_adaptation1.64166098
19MP0002736_abnormal_nociception_after1.61924457
20MP0003136_yellow_coat_color1.60258907
21MP0003718_maternal_effect1.60213632
22MP0005253_abnormal_eye_physiology1.60034134
23MP0005646_abnormal_pituitary_gland1.58712532
24MP0000372_irregular_coat_pigmentation1.57137920
25MP0008872_abnormal_physiological_respon1.57072003
26MP0002160_abnormal_reproductive_system1.54911741
27MP0002653_abnormal_ependyma_morphology1.54125014
28MP0003937_abnormal_limbs/digits/tail_de1.53830354
29MP0005645_abnormal_hypothalamus_physiol1.48827968
30MP0003195_calcinosis1.48498560
31MP0000049_abnormal_middle_ear1.42419223
32MP0002751_abnormal_autonomic_nervous1.41853908
33MP0000631_abnormal_neuroendocrine_gland1.41463919
34MP0003787_abnormal_imprinting1.40542020
35MP0001968_abnormal_touch/_nociception1.38668692
36MP0009046_muscle_twitch1.38474377
37MP0004142_abnormal_muscle_tone1.33865438
38MP0003119_abnormal_digestive_system1.30994283
39MP0002234_abnormal_pharynx_morphology1.30368655
40MP0005389_reproductive_system_phenotype1.27463402
41MP0001485_abnormal_pinna_reflex1.27387182
42MP0008789_abnormal_olfactory_epithelium1.27078673
43MP0003121_genomic_imprinting1.27005888
44MP0002163_abnormal_gland_morphology1.26658472
45MP0000427_abnormal_hair_cycle1.26489797
46MP0000569_abnormal_digit_pigmentation1.24380901
47MP0002876_abnormal_thyroid_physiology1.22056380
48MP0004957_abnormal_blastocyst_morpholog1.21609573
49MP0003111_abnormal_nucleus_morphology1.21429768
50MP0004885_abnormal_endolymph1.19831869
51MP0008932_abnormal_embryonic_tissue1.19573357
52MP0006276_abnormal_autonomic_nervous1.16669633
53MP0003786_premature_aging1.14990282
54MP0002735_abnormal_chemical_nociception1.14305802
55MP0004145_abnormal_muscle_electrophysio1.13541940
56MP0001919_abnormal_reproductive_system1.11473010
57MP0008995_early_reproductive_senescence1.11379708
58MP0002272_abnormal_nervous_system1.09993135
59MP0005084_abnormal_gallbladder_morpholo1.09549967
60MP0009745_abnormal_behavioral_response1.09054898
61MP0003880_abnormal_central_pattern1.07723703
62MP0006035_abnormal_mitochondrial_morpho1.07385828
63MP0008875_abnormal_xenobiotic_pharmacok1.05275298
64MP0003938_abnormal_ear_development1.04421720
65MP0003077_abnormal_cell_cycle1.03974657
66MP0000778_abnormal_nervous_system1.03144430
67MP0002184_abnormal_innervation1.02955014
68MP0002210_abnormal_sex_determination1.01074209
69MP0003186_abnormal_redox_activity1.00607584
70MP0004043_abnormal_pH_regulation1.00158420
71MP0003567_abnormal_fetal_cardiomyocyte0.99810315
72MP0005195_abnormal_posterior_eye0.99365108
73MP0000647_abnormal_sebaceous_gland0.99357882
74MP0000383_abnormal_hair_follicle0.99000011
75MP0005391_vision/eye_phenotype0.96015578
76MP0002557_abnormal_social/conspecific_i0.94938999
77MP0003315_abnormal_perineum_morphology0.93192228
78MP0002752_abnormal_somatic_nervous0.91182115
79MP0002822_catalepsy0.89248942
80MP0002095_abnormal_skin_pigmentation0.86798014
81MP0001984_abnormal_olfaction0.85901828
82MP0009697_abnormal_copulation0.85897673
83MP0001286_abnormal_eye_development0.85767865
84MP0010030_abnormal_orbit_morphology0.85016798
85MP0005394_taste/olfaction_phenotype0.84954241
86MP0005499_abnormal_olfactory_system0.84954241
87MP0009379_abnormal_foot_pigmentation0.83772731
88MP0002277_abnormal_respiratory_mucosa0.82938217
89MP0001905_abnormal_dopamine_level0.82167883
90MP0006036_abnormal_mitochondrial_physio0.81851997
91MP0001145_abnormal_male_reproductive0.81277175
92MP0001929_abnormal_gametogenesis0.80482387
93MP0000026_abnormal_inner_ear0.80351092
94MP0002734_abnormal_mechanical_nocicepti0.80263251
95MP0004924_abnormal_behavior0.80061900
96MP0005386_behavior/neurological_phenoty0.80061900
97MP0002572_abnormal_emotion/affect_behav0.79798492
98MP0008007_abnormal_cellular_replicative0.79002823
99MP0000653_abnormal_sex_gland0.78552684
100MP0005174_abnormal_tail_pigmentation0.78173178

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.89884136
2Pancreatic cysts (HP:0001737)3.72755516
3Pancreatic fibrosis (HP:0100732)3.44840518
4Acute necrotizing encephalopathy (HP:0006965)3.29528910
5True hermaphroditism (HP:0010459)3.28979814
6Pendular nystagmus (HP:0012043)3.16296089
7Molar tooth sign on MRI (HP:0002419)3.15062984
8Abnormality of midbrain morphology (HP:0002418)3.15062984
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.05063922
10Abnormality of alanine metabolism (HP:0010916)3.05063922
11Hyperalaninemia (HP:0003348)3.05063922
12Acute encephalopathy (HP:0006846)3.01814756
13Abnormal mitochondria in muscle tissue (HP:0008316)2.96757651
14Mitochondrial inheritance (HP:0001427)2.94646402
15Increased CSF lactate (HP:0002490)2.88364003
16Congenital stationary night blindness (HP:0007642)2.86568651
17Nephronophthisis (HP:0000090)2.85901624
18Type II lissencephaly (HP:0007260)2.81888648
19Progressive macrocephaly (HP:0004481)2.68591962
20Increased hepatocellular lipid droplets (HP:0006565)2.62355290
21Patellar aplasia (HP:0006443)2.62104741
22Aplasia/Hypoplasia of the patella (HP:0006498)2.56895400
23Medial flaring of the eyebrow (HP:0010747)2.51244077
24Lipid accumulation in hepatocytes (HP:0006561)2.51151140
25Sclerocornea (HP:0000647)2.44221688
263-Methylglutaconic aciduria (HP:0003535)2.43951145
27Methylmalonic acidemia (HP:0002912)2.40632740
28Abnormality of the labia minora (HP:0012880)2.36513991
29Hepatocellular necrosis (HP:0001404)2.36436144
30Abnormality of the renal medulla (HP:0100957)2.34348655
31Congenital, generalized hypertrichosis (HP:0004540)2.30455553
32Increased serum lactate (HP:0002151)2.26496684
33Chorioretinal atrophy (HP:0000533)2.22316600
34Abnormality of the renal cortex (HP:0011035)2.21385052
35Abolished electroretinogram (ERG) (HP:0000550)2.20951255
36Lissencephaly (HP:0001339)2.20578096
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.18641028
38Abnormal number of erythroid precursors (HP:0012131)2.18315621
39Abnormality of the pons (HP:0007361)2.17756505
40Colon cancer (HP:0003003)2.15258570
41Meckel diverticulum (HP:0002245)2.15013774
42Abnormality of the ileum (HP:0001549)2.14273092
43Hepatic necrosis (HP:0002605)2.13172965
44Gait imbalance (HP:0002141)2.12678909
45Microretrognathia (HP:0000308)2.12655275
46Concave nail (HP:0001598)2.12487027
47Methylmalonic aciduria (HP:0012120)2.11105288
48Congenital primary aphakia (HP:0007707)2.09970859
49Cerebral edema (HP:0002181)2.09184906
50Optic disc pallor (HP:0000543)2.06513608
51Abnormality of cells of the erythroid lineage (HP:0012130)2.05615438
52Anencephaly (HP:0002323)2.04806120
53Hyperglycinemia (HP:0002154)2.02929886
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.02468545
55Absent thumb (HP:0009777)2.02338189
56Hypoplasia of the pons (HP:0012110)2.02317486
57Abnormality of the renal collecting system (HP:0004742)2.00336428
58Renal Fanconi syndrome (HP:0001994)1.99820849
59Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99812784
60Attenuation of retinal blood vessels (HP:0007843)1.98535556
61Cystic liver disease (HP:0006706)1.97365239
62Lactic acidosis (HP:0003128)1.97298303
63Increased corneal curvature (HP:0100692)1.96840612
64Keratoconus (HP:0000563)1.96840612
65Abnormality of serum amino acid levels (HP:0003112)1.96576576
66Stenosis of the external auditory canal (HP:0000402)1.95490216
67Nephrogenic diabetes insipidus (HP:0009806)1.95100894
68Chronic hepatic failure (HP:0100626)1.94333370
69Chromsome breakage (HP:0040012)1.90751011
70Hyperventilation (HP:0002883)1.87807110
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87346431
72Small hand (HP:0200055)1.87345625
73Genital tract atresia (HP:0001827)1.86814922
74Vaginal atresia (HP:0000148)1.85576340
75Male pseudohermaphroditism (HP:0000037)1.85348119
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.84821598
77Breast hypoplasia (HP:0003187)1.83633918
78Cerebellar dysplasia (HP:0007033)1.83516040
79Inability to walk (HP:0002540)1.82859189
80Abnormality of chromosome stability (HP:0003220)1.81966494
81Renal cortical cysts (HP:0000803)1.81547472
82Preaxial hand polydactyly (HP:0001177)1.80247356
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.78594962
84Bile duct proliferation (HP:0001408)1.77210292
85Abnormal biliary tract physiology (HP:0012439)1.77210292
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74439957
87Neoplasm of the adrenal cortex (HP:0100641)1.74433080
88Retinal dysplasia (HP:0007973)1.72936010
89Abnormal rod and cone electroretinograms (HP:0008323)1.72493583
90Furrowed tongue (HP:0000221)1.70456714
91Dandy-Walker malformation (HP:0001305)1.70202113
92Postaxial foot polydactyly (HP:0001830)1.69821379
93Aplasia/hypoplasia of the uterus (HP:0008684)1.69462705
94Abnormality of the preputium (HP:0100587)1.67923200
95Large for gestational age (HP:0001520)1.67767760
96Sloping forehead (HP:0000340)1.67299937
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67185634
98Broad-based gait (HP:0002136)1.66001335
99Bilateral microphthalmos (HP:0007633)1.65853941
100Hyperglycinuria (HP:0003108)1.65773776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.70566843
2BMPR1B3.33558116
3FRK2.76083522
4TLK12.54226474
5VRK22.47442871
6MAP4K22.45725944
7NUAK12.37451511
8ADRBK22.32542447
9WNK32.21425785
10ACVR1B2.20368112
11BUB12.15491512
12CASK2.11293204
13CDC72.04675648
14WNK42.00436073
15STK161.91920236
16INSRR1.86171542
17GRK11.82330184
18SRPK11.80209985
19MKNK21.73253073
20NME11.70582442
21VRK11.66037610
22BCKDK1.63479906
23PINK11.58355718
24MAP3K41.49744875
25DYRK21.47447516
26PLK31.39435802
27TRIM281.39421950
28WEE11.36348465
29MAP2K71.35448441
30EIF2AK31.30590591
31NEK11.29064813
32MKNK11.25705612
33CSNK1G11.22134997
34CSNK1G31.21322104
35PLK11.21307706
36TTK1.18606277
37CSNK1G21.17306969
38STK391.16729257
39TSSK61.16589148
40PLK41.16181609
41BRSK21.13714623
42TAF11.13230619
43MAPK131.13171851
44TGFBR11.11585988
45NEK21.11173368
46TNIK1.06855057
47BCR1.04247033
48CHEK21.03558542
49ATR1.03226227
50DAPK21.02128111
51MST41.01970175
52CSNK1A1L1.00341256
53PBK0.96772487
54EIF2AK10.92242012
55OXSR10.86172789
56ADRBK10.83993961
57PNCK0.80719836
58EIF2AK20.76785284
59STK38L0.76649566
60RPS6KA50.75606286
61PRKCG0.74787126
62TAOK30.71238992
63AURKA0.71055760
64PLK20.69996841
65PHKG20.68366001
66PHKG10.68366001
67MARK10.68041123
68AURKB0.67507615
69PIK3CA0.66030843
70PRKCI0.64578465
71PAK30.61742866
72MUSK0.59760249
73TXK0.59578015
74ERBB30.56832114
75CSNK1A10.56430997
76ATM0.54876272
77TIE10.54234582
78PRKCE0.53502248
79DYRK30.51966880
80BRSK10.51209609
81CDK80.48768572
82CSNK2A10.48611031
83LIMK10.47825382
84CDK190.47693368
85NTRK20.44685346
86MAPKAPK50.44133118
87RPS6KB20.43440426
88CSNK1E0.43030171
89CAMK2A0.42815345
90CHEK10.39826833
91PDK20.39717706
92CSNK1D0.38285143
93CDK70.37538840
94RPS6KA40.37342923
95CAMKK20.37002357
96CSNK2A20.35989354
97MAPKAPK30.34615990
98PRKACA0.32926382
99CDK30.32822496
100STK30.32277317

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.11148415
2Ribosome_Homo sapiens_hsa030102.74953043
3Proteasome_Homo sapiens_hsa030502.67490955
4RNA polymerase_Homo sapiens_hsa030202.66454246
5Homologous recombination_Homo sapiens_hsa034402.55580380
6Parkinsons disease_Homo sapiens_hsa050122.55113883
7Protein export_Homo sapiens_hsa030602.50569900
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36207238
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33937264
10Basal transcription factors_Homo sapiens_hsa030222.10404069
11Fanconi anemia pathway_Homo sapiens_hsa034602.03898141
12DNA replication_Homo sapiens_hsa030302.01437808
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96695374
14Phototransduction_Homo sapiens_hsa047441.89352264
15Huntingtons disease_Homo sapiens_hsa050161.88367956
16RNA degradation_Homo sapiens_hsa030181.85461828
17Mismatch repair_Homo sapiens_hsa034301.83189498
18One carbon pool by folate_Homo sapiens_hsa006701.80779195
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80322549
20Selenocompound metabolism_Homo sapiens_hsa004501.79533741
21Nucleotide excision repair_Homo sapiens_hsa034201.78921033
22Non-homologous end-joining_Homo sapiens_hsa034501.67503838
23Alzheimers disease_Homo sapiens_hsa050101.66455807
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58128380
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54225100
26Sulfur relay system_Homo sapiens_hsa041221.53324392
27RNA transport_Homo sapiens_hsa030131.53202138
28Pyrimidine metabolism_Homo sapiens_hsa002401.52214046
29Nitrogen metabolism_Homo sapiens_hsa009101.48635927
30Spliceosome_Homo sapiens_hsa030401.47818822
31Base excision repair_Homo sapiens_hsa034101.47521650
32Butanoate metabolism_Homo sapiens_hsa006501.39867883
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38932360
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36149676
35Propanoate metabolism_Homo sapiens_hsa006401.34567908
36Steroid biosynthesis_Homo sapiens_hsa001001.29459621
37Nicotine addiction_Homo sapiens_hsa050331.29454860
38Cardiac muscle contraction_Homo sapiens_hsa042601.29083918
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28937479
40Linoleic acid metabolism_Homo sapiens_hsa005911.28755572
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.23922686
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20250031
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19353138
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16714735
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16163603
46Purine metabolism_Homo sapiens_hsa002301.13616971
47Tryptophan metabolism_Homo sapiens_hsa003801.12509390
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.12039462
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08030831
50Caffeine metabolism_Homo sapiens_hsa002321.05571898
51Cell cycle_Homo sapiens_hsa041100.96035294
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94421175
53Peroxisome_Homo sapiens_hsa041460.91910942
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91266304
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87968784
56Sulfur metabolism_Homo sapiens_hsa009200.85143899
57Metabolic pathways_Homo sapiens_hsa011000.84090832
58Pyruvate metabolism_Homo sapiens_hsa006200.83868248
59Ether lipid metabolism_Homo sapiens_hsa005650.80512959
60Folate biosynthesis_Homo sapiens_hsa007900.79954005
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76378763
62Chemical carcinogenesis_Homo sapiens_hsa052040.74038881
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69402765
64Retinol metabolism_Homo sapiens_hsa008300.65863183
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65554973
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.65438818
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64182397
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.61920487
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61526754
70p53 signaling pathway_Homo sapiens_hsa041150.58671520
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57776686
72beta-Alanine metabolism_Homo sapiens_hsa004100.56057200
73Olfactory transduction_Homo sapiens_hsa047400.55030057
74Vitamin digestion and absorption_Homo sapiens_hsa049770.54221985
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54107306
76Taste transduction_Homo sapiens_hsa047420.53361254
77Glutathione metabolism_Homo sapiens_hsa004800.53310781
78Fatty acid elongation_Homo sapiens_hsa000620.49967919
79Collecting duct acid secretion_Homo sapiens_hsa049660.49829581
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49157267
81Basal cell carcinoma_Homo sapiens_hsa052170.47654886
82Morphine addiction_Homo sapiens_hsa050320.47276088
83Regulation of autophagy_Homo sapiens_hsa041400.45242254
84Fat digestion and absorption_Homo sapiens_hsa049750.44504211
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43295003
86Glycerolipid metabolism_Homo sapiens_hsa005610.42083804
87Vitamin B6 metabolism_Homo sapiens_hsa007500.41916363
88mRNA surveillance pathway_Homo sapiens_hsa030150.40791059
89Arginine and proline metabolism_Homo sapiens_hsa003300.40686564
90GABAergic synapse_Homo sapiens_hsa047270.38813692
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38714235
92Hedgehog signaling pathway_Homo sapiens_hsa043400.37239595
93Serotonergic synapse_Homo sapiens_hsa047260.35564025
94Fatty acid biosynthesis_Homo sapiens_hsa000610.33811430
95Arachidonic acid metabolism_Homo sapiens_hsa005900.33348978
96Hippo signaling pathway_Homo sapiens_hsa043900.33065839
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.31985411
98Alcoholism_Homo sapiens_hsa050340.31690750
99Fatty acid metabolism_Homo sapiens_hsa012120.29955848
100Fatty acid degradation_Homo sapiens_hsa000710.29890322

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