MERTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)5.92161048
2cellular response to thyroid hormone stimulus (GO:0097067)5.41012805
3regulation of interferon-beta biosynthetic process (GO:0045357)5.38012751
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.36611868
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.36611868
6modulation by symbiont of host immune response (GO:0052553)5.36611868
7positive regulation by symbiont of host defense response (GO:0052509)5.36611868
8modulation by symbiont of host defense response (GO:0052031)5.36611868
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.36611868
10macrophage activation involved in immune response (GO:0002281)4.85237209
11glomerular visceral epithelial cell development (GO:0072015)4.62754039
12glycolipid catabolic process (GO:0019377)4.59068926
13plasma lipoprotein particle clearance (GO:0034381)4.57745359
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34709403
15response to thyroid hormone (GO:0097066)4.33906072
16positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.33771011
17N-acetylneuraminate metabolic process (GO:0006054)4.28753485
18detection of molecule of bacterial origin (GO:0032490)4.22592251
19glomerular epithelial cell development (GO:0072310)4.13379700
20positive regulation of interferon-alpha production (GO:0032727)4.07414091
21amino sugar catabolic process (GO:0046348)4.06386643
22regulation of apoptotic cell clearance (GO:2000425)4.02190904
23barbed-end actin filament capping (GO:0051016)4.01656772
24positive regulation of cellular amide metabolic process (GO:0034250)3.99129895
25ceramide catabolic process (GO:0046514)3.94084286
26pinocytosis (GO:0006907)3.92364674
27positive regulation of leukocyte degranulation (GO:0043302)3.92291837
28complement activation, alternative pathway (GO:0006957)3.89516592
29regulation of interferon-alpha production (GO:0032647)3.81203229
30very-low-density lipoprotein particle assembly (GO:0034379)3.80163994
31plasma lipoprotein particle remodeling (GO:0034369)3.79632484
32protein-lipid complex remodeling (GO:0034368)3.79632484
33macromolecular complex remodeling (GO:0034367)3.79632484
34positive regulation of chemokine secretion (GO:0090197)3.79406187
35low-density lipoprotein particle clearance (GO:0034383)3.78579631
36cellular response to cadmium ion (GO:0071276)3.75968638
37negative regulation of interleukin-12 production (GO:0032695)3.75814693
38macrophage activation (GO:0042116)3.75804401
39plasma lipoprotein particle organization (GO:0071827)3.63517186
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.58493725
41positive regulation of mast cell degranulation (GO:0043306)3.51098765
42positive regulation of mast cell activation involved in immune response (GO:0033008)3.51098765
43negative regulation of sterol transport (GO:0032372)3.50443797
44negative regulation of cholesterol transport (GO:0032375)3.50443797
45high-density lipoprotein particle remodeling (GO:0034375)3.41723266
46regulation of superoxide anion generation (GO:0032928)3.38881427
47regulation of leukocyte degranulation (GO:0043300)3.38583721
48adenosine receptor signaling pathway (GO:0001973)3.37911743
49G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37872513
50regulation of mast cell degranulation (GO:0043304)3.37070682
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33110640
52response to host immune response (GO:0052572)3.31206838
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31206838
54I-kappaB phosphorylation (GO:0007252)3.26434984
55macrophage differentiation (GO:0030225)3.25938038
56glomerular basement membrane development (GO:0032836)3.25579222
57membrane lipid catabolic process (GO:0046466)3.21094607
58positive regulation of extracellular matrix organization (GO:1903055)3.19567259
59* positive regulation of phagocytosis (GO:0050766)3.16368757
60positive regulation of mast cell activation (GO:0033005)3.13588048
61response to host (GO:0075136)3.11289436
62response to host defenses (GO:0052200)3.11289436
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11289436
64regulation of mast cell activation involved in immune response (GO:0033006)3.11120628
65negative regulation of granulocyte differentiation (GO:0030853)3.10369005
66negative regulation of fibrinolysis (GO:0051918)3.08075809
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.07951826
68response to cholesterol (GO:0070723)3.05702785
69* apoptotic cell clearance (GO:0043277)3.03426016
70sphingolipid catabolic process (GO:0030149)3.03058952
71positive regulation of triglyceride lipase activity (GO:0061365)3.02664804
72positive regulation of lipoprotein lipase activity (GO:0051006)3.02664804
73mannose metabolic process (GO:0006013)3.02606022
74peptide catabolic process (GO:0043171)3.01896108
75cellular response to ethanol (GO:0071361)3.01158390
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98568099
77regulation of cholesterol biosynthetic process (GO:0045540)2.98398487
78positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.97668567
79epithelial cell differentiation involved in prostate gland development (GO:0060742)2.95347674
80regulation of macrophage chemotaxis (GO:0010758)2.94290890
81lytic vacuole organization (GO:0080171)2.93855369
82lysosome organization (GO:0007040)2.93855369
83phagocytosis, engulfment (GO:0006911)2.92305031
84regulation of protein activation cascade (GO:2000257)2.91905767
85cholesterol transport (GO:0030301)2.91834105
86sterol transport (GO:0015918)2.91834105
87cell-cell junction maintenance (GO:0045217)2.91497659
88detection of external biotic stimulus (GO:0098581)2.90123593
89regulation of complement activation (GO:0030449)2.89904506
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89668873
91lipoprotein metabolic process (GO:0042157)2.88161976
92protein localization to endosome (GO:0036010)2.87794679
93chondroitin sulfate catabolic process (GO:0030207)2.86748668
94phospholipid efflux (GO:0033700)2.83697505
95regulation of beta-amyloid formation (GO:1902003)2.82500302
96negative regulation of erythrocyte differentiation (GO:0045647)2.80539168
97alanine transport (GO:0032328)2.79673954
98positive regulation of steroid metabolic process (GO:0045940)2.79343672
99monocyte chemotaxis (GO:0002548)2.75906356
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.75682239
101eosinophil chemotaxis (GO:0048245)2.73909445
102lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72965512
103reverse cholesterol transport (GO:0043691)2.72938320
104regulation of chemokine secretion (GO:0090196)2.71776793
105regulation of hypersensitivity (GO:0002883)2.69887352
106negative regulation of tissue remodeling (GO:0034104)2.69386140
107oligosaccharide catabolic process (GO:0009313)2.68487900
108positive regulation of macrophage cytokine production (GO:0060907)2.65915535
109T-helper 1 type immune response (GO:0042088)2.65253148
110regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.64010586
111osteoclast differentiation (GO:0030316)2.63511909
112G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.62364247
113sodium-independent organic anion transport (GO:0043252)2.62095594
114response to sterol (GO:0036314)2.61046506
115positive regulation of p38MAPK cascade (GO:1900745)2.57817075
116phospholipid homeostasis (GO:0055091)2.55961082
117positive regulation of cholesterol efflux (GO:0010875)2.54858586
118positive regulation of interferon-beta production (GO:0032728)2.54748172
119negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.54344706
120low-density lipoprotein particle remodeling (GO:0034374)2.53908174
121myeloid cell activation involved in immune response (GO:0002275)2.52202928
122negative regulation of bone resorption (GO:0045779)2.51066962
123response to muramyl dipeptide (GO:0032495)2.48918634
124response to peptidoglycan (GO:0032494)2.47353540
125keratan sulfate catabolic process (GO:0042340)2.47335660
126L-amino acid import (GO:0043092)2.45384850
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45218206
128angiotensin maturation (GO:0002003)2.44385460
129protein-lipid complex assembly (GO:0065005)2.44278096
130monocyte differentiation (GO:0030224)2.42901646
131protein carboxylation (GO:0018214)2.42859510
132peptidyl-glutamic acid carboxylation (GO:0017187)2.42859510
133plasma lipoprotein particle assembly (GO:0034377)2.42016098
134regulation of cholesterol storage (GO:0010885)2.41211048
135purinergic receptor signaling pathway (GO:0035587)2.41160314
136neutrophil activation involved in immune response (GO:0002283)2.40413646
137cellular extravasation (GO:0045123)2.39050105
138positive regulation of monocyte chemotaxis (GO:0090026)2.37382274
139endothelium development (GO:0003158)2.37190989
140eosinophil migration (GO:0072677)2.33015375
141regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.32572102
142glycosphingolipid catabolic process (GO:0046479)2.31210980
143regulation of cholesterol esterification (GO:0010872)2.30727469
144ruffle organization (GO:0031529)2.30310348
145positive regulation of sterol transport (GO:0032373)2.29585878
146positive regulation of cholesterol transport (GO:0032376)2.29585878
147regulation of interferon-gamma biosynthetic process (GO:0045072)2.29109600
148macrophage chemotaxis (GO:0048246)2.28662661
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.28451543
150regulation of alkaline phosphatase activity (GO:0010692)2.28250906
151epithelial cell differentiation involved in kidney development (GO:0035850)2.27427426
152cholesterol efflux (GO:0033344)2.27332245
153regulation of mononuclear cell migration (GO:0071675)2.26346939
154positive regulation of smooth muscle cell migration (GO:0014911)2.26203905
155negative regulation of lipid storage (GO:0010888)2.25014420
156cellular response to exogenous dsRNA (GO:0071360)2.24269894
157hyaluronan catabolic process (GO:0030214)2.22630748
158cell adhesion mediated by integrin (GO:0033627)2.21281568
159pathway-restricted SMAD protein phosphorylation (GO:0060389)2.20609796
160alpha-linolenic acid metabolic process (GO:0036109)2.20593959
161protein-lipid complex subunit organization (GO:0071825)2.19363645
162positive regulation of antigen processing and presentation (GO:0002579)2.18129594
163regulation of B cell receptor signaling pathway (GO:0050855)2.17547677
164amino acid import (GO:0043090)2.17158917
165glomerulus development (GO:0032835)2.16904666
166regulation of monocyte chemotaxis (GO:0090025)2.16722453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.60228710
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.30546069
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.03954687
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.02354196
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62078376
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.60575956
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.57380720
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23475584
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20660006
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.11813850
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07764036
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04356210
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02361192
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.00648262
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83848902
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78803777
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78117859
18VDR_24763502_ChIP-Seq_THP-1_Human1.75743209
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74988106
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70581160
21VDR_24787735_ChIP-Seq_THP-1_Human1.65375710
22LXR_22292898_ChIP-Seq_THP-1_Human1.57818968
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57773516
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.57415714
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56565923
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.56313224
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55391720
28RUNX_20019798_ChIP-Seq_JUKART_Human1.55166907
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52958202
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51810374
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51518243
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48575558
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46328618
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.45851084
35VDR_21846776_ChIP-Seq_THP-1_Human1.43061466
36* GATA2_21666600_ChIP-Seq_HMVEC_Human1.41643811
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39955074
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39244580
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38352620
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35109938
41TP53_16413492_ChIP-PET_HCT116_Human1.33359360
42* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32972028
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32502627
44* SPI1_23547873_ChIP-Seq_NB4_Human1.29089526
45* SPI1_23127762_ChIP-Seq_K562_Human1.28543764
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27248302
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.26716198
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.24945180
49* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24084074
50SCL_19346495_ChIP-Seq_HPC-7_Human1.23160802
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22888003
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.20804710
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19548671
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.18320762
55GATA1_22025678_ChIP-Seq_K562_Human1.17801740
56CLOCK_20551151_ChIP-Seq_293T_Human1.17511825
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17385920
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17035666
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17027123
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16454423
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.16426697
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16349589
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.15280065
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.15280065
65KDM2B_26808549_Chip-Seq_K562_Human1.14862901
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14159227
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13761512
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13179343
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12981767
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12806033
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12626066
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.12079522
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11576823
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10963319
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10570651
76DROSHA_22980978_ChIP-Seq_HELA_Human1.09835911
77TFEB_21752829_ChIP-Seq_HELA_Human1.08808670
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08420925
79RXR_22108803_ChIP-Seq_LS180_Human1.07807446
80* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06156020
81TCF7_22412390_ChIP-Seq_EML_Mouse1.05085844
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04518155
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04196534
84* CJUN_26792858_Chip-Seq_BT549_Human1.04122763
85GATA2_19941826_ChIP-Seq_K562_Human1.03424678
86GBX2_23144817_ChIP-Seq_PC3_Human1.02215136
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01867558
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01867558
89* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01378598
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01311530
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01269072
92* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00826811
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00298986
94* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00208462
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.99019483
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98398039
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97940469
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97508850
99PU_27001747_Chip-Seq_BMDM_Mouse0.96777358
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96733211
101AHR_22903824_ChIP-Seq_MCF-7_Human0.96354551
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94972509
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93990660
104BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93265704
105SOX2_20726797_ChIP-Seq_SW620_Human0.93265021
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93026651
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92997485
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92264314
109GATA1_19941826_ChIP-Seq_K562_Human0.90871166
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.90034689
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89404964
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89303346
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89155206
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.88947445
115* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88834013
116* MITF_21258399_ChIP-Seq_MELANOMA_Human0.88303210
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87951901
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87862125
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87142793
120TP53_18474530_ChIP-ChIP_U2OS_Human0.86986573
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85587062
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.85550866
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84454206
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84197680
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83683760
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83007483
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82959532
128MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82166740
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82043301
130* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82038664
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81405959
132ZNF263_19887448_ChIP-Seq_K562_Human0.81304377
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.79592982
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79127748
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78854334
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77759096
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77736601
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77640477
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77010865
140* TP63_23658742_ChIP-Seq_EP156T_Human0.75685739
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74803876
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.72756856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol4.43748918
2MP0005058_abnormal_lysosome_morphology4.24483298
3MP0009840_abnormal_foam_cell3.79984415
4MP0006082_CNS_inflammation3.38904189
5MP0003690_abnormal_glial_cell3.08471343
6MP0002254_reproductive_system_inflammat2.87480218
7MP0005360_urolithiasis2.80341805
8MP0003329_amyloid_beta_deposits2.67087722
9MP0003172_abnormal_lysosome_physiology2.63092824
10MP0005167_abnormal_blood-brain_barrier2.62461587
11MP0003303_peritoneal_inflammation2.60426365
12MP0003075_altered_response_to2.41585432
13MP0001835_abnormal_antigen_presentation2.37495808
14MP0002419_abnormal_innate_immunity2.35697212
15MP0003252_abnormal_bile_duct2.28725660
16MP0003300_gastrointestinal_ulcer2.18829476
17MP0002139_abnormal_hepatobiliary_system2.04474562
18MP0003724_increased_susceptibility_to2.03390576
19* MP0005464_abnormal_platelet_physiology1.88358272
20MP0005085_abnormal_gallbladder_physiolo1.85645694
21MP0005670_abnormal_white_adipose1.85463064
22MP0003436_decreased_susceptibility_to1.82645627
23MP0003183_abnormal_peptide_metabolism1.81534148
24MP0002148_abnormal_hypersensitivity_rea1.79384584
25MP0000685_abnormal_immune_system1.68129368
26MP0005166_decreased_susceptibility_to1.68123902
27MP0003195_calcinosis1.66392112
28MP0000343_altered_response_to1.64542858
29MP0005365_abnormal_bile_salt1.64352574
30MP0001533_abnormal_skeleton_physiology1.62746834
31MP0002998_abnormal_bone_remodeling1.62289160
32MP0005451_abnormal_body_composition1.60564936
33MP0008260_abnormal_autophagy1.57648376
34MP0010329_abnormal_lipoprotein_level1.56910320
35MP0000604_amyloidosis1.55263531
36MP0002452_abnormal_antigen_presenting1.54271141
37MP0000569_abnormal_digit_pigmentation1.53270800
38MP0009384_cardiac_valve_regurgitation1.50610643
39MP0003279_aneurysm1.48661477
40MP0004019_abnormal_vitamin_homeostasis1.45445623
41* MP0008469_abnormal_protein_level1.42507076
42MP0005332_abnormal_amino_acid1.42145472
43MP0001853_heart_inflammation1.41993062
44MP0003632_abnormal_nervous_system1.41252756
45MP0003045_fibrosis1.41147248
46MP0008875_abnormal_xenobiotic_pharmacok1.39406586
47* MP0005000_abnormal_immune_tolerance1.39092456
48MP0005025_abnormal_response_to1.38404450
49MP0001545_abnormal_hematopoietic_system1.36107898
50MP0005397_hematopoietic_system_phenotyp1.36107898
51MP0005387_immune_system_phenotype1.32131459
52MP0001790_abnormal_immune_system1.32131459
53MP0009764_decreased_sensitivity_to1.32106251
54* MP0002723_abnormal_immune_serum1.31449634
55MP0006054_spinal_hemorrhage1.27458758
56MP0002136_abnormal_kidney_physiology1.25902553
57MP0000767_abnormal_smooth_muscle1.19250995
58MP0001800_abnormal_humoral_immune1.17435004
59MP0004510_myositis1.15625615
60* MP0001845_abnormal_inflammatory_respons1.13870265
61MP0004883_abnormal_blood_vessel1.13782763
62* MP0005671_abnormal_response_to1.11481386
63MP0001851_eye_inflammation1.10867194
64MP0010368_abnormal_lymphatic_system1.10245328
65MP0005666_abnormal_adipose_tissue1.09929297
66MP0004130_abnormal_muscle_cell1.09355972
67MP0005164_abnormal_response_to1.08762016
68MP0000609_abnormal_liver_physiology1.08665392
69* MP0001819_abnormal_immune_cell1.08356926
70MP0000858_altered_metastatic_potential1.07426840
71MP0008004_abnormal_stomach_pH1.07260623
72MP0002118_abnormal_lipid_homeostasis1.06299393
73MP0004947_skin_inflammation1.05782536
74MP0009643_abnormal_urine_homeostasis1.05704466
75MP0003011_delayed_dark_adaptation1.03906885
76* MP0002420_abnormal_adaptive_immunity1.03597788
77MP0001666_abnormal_nutrient_absorption1.03401306
78MP0005310_abnormal_salivary_gland1.03318861
79MP0000249_abnormal_blood_vessel1.03048272
80MP0003566_abnormal_cell_adhesion1.02831976
81MP0005377_hearing/vestibular/ear_phenot1.01930168
82MP0003878_abnormal_ear_physiology1.01930168
83MP0009785_altered_susceptibility_to1.01508207
84MP0003453_abnormal_keratinocyte_physiol1.01415496
85MP0002405_respiratory_system_inflammati1.01257691
86MP0009278_abnormal_bone_marrow1.00788059
87MP0002896_abnormal_bone_mineralization0.98059729
88MP0001915_intracranial_hemorrhage0.97818808
89MP0002877_abnormal_melanocyte_morpholog0.96865343
90MP0001879_abnormal_lymphatic_vessel0.96591176
91MP0005595_abnormal_vascular_smooth0.95362188
92MP0003633_abnormal_nervous_system0.94326364
93MP0003705_abnormal_hypodermis_morpholog0.93131278
94MP0002135_abnormal_kidney_morphology0.92726548
95MP0004185_abnormal_adipocyte_glucose0.92261412
96MP0003091_abnormal_cell_migration0.89875124
97MP0005165_increased_susceptibility_to0.89633094
98MP0003631_nervous_system_phenotype0.88451245
99MP0005076_abnormal_cell_differentiation0.86617279
100MP0003828_pulmonary_edema0.86389922
101MP0005257_abnormal_intraocular_pressure0.86063293
102MP0003656_abnormal_erythrocyte_physiolo0.85127260
103MP0004272_abnormal_basement_membrane0.85011249
104MP0003448_altered_tumor_morphology0.84768855
105MP0000465_gastrointestinal_hemorrhage0.83674550
106MP0002928_abnormal_bile_duct0.82856904
107MP0001756_abnormal_urination0.80766616
108MP0003879_abnormal_hair_cell0.80643319
109MP0005023_abnormal_wound_healing0.80501058
110MP0002971_abnormal_brown_adipose0.79875222
111MP0005647_abnormal_sex_gland0.78945678
112MP0002933_joint_inflammation0.78339171
113MP0003795_abnormal_bone_structure0.77582266
114MP0000371_diluted_coat_color0.77460074
115MP0002138_abnormal_hepatobiliary_system0.77435294
116MP0005390_skeleton_phenotype0.77253532
117* MP0009763_increased_sensitivity_to0.77045842
118MP0005197_abnormal_uvea_morphology0.76305777
119MP0000920_abnormal_myelination0.75409087
120MP0005584_abnormal_enzyme/coenzyme_acti0.75191235
121MP0009115_abnormal_fat_cell0.73805980
122MP0002166_altered_tumor_susceptibility0.73501056
123MP0000230_abnormal_systemic_arterial0.72920549
124MP0002168_other_aberrant_phenotype0.72710343
125MP0003634_abnormal_glial_cell0.71370329
126MP0001849_ear_inflammation0.66960213
127* MP0002090_abnormal_vision0.65982069
128MP0003806_abnormal_nucleotide_metabolis0.61829817

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.37910620
2Glomerulonephritis (HP:0000099)6.96677033
3Complement deficiency (HP:0004431)4.90221925
4Nephritis (HP:0000123)4.80000255
5Abnormality of glycolipid metabolism (HP:0010969)4.30331187
6Abnormality of liposaccharide metabolism (HP:0010968)4.30331187
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.30331187
8Increased cerebral lipofuscin (HP:0011813)4.24095361
9Dysostosis multiplex (HP:0000943)3.97655700
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.96317600
11Recurrent abscess formation (HP:0002722)3.75418094
12Recurrent bacterial skin infections (HP:0005406)3.74133194
13Cerebral inclusion bodies (HP:0100314)3.70396158
14Abnormality of the vasculature of the conjunctiva (HP:0008054)3.69237937
15Arterial tortuosity (HP:0005116)3.64052004
16Abnormality of complement system (HP:0005339)3.59563138
17Vacuolated lymphocytes (HP:0001922)3.51774049
18Eczematoid dermatitis (HP:0000976)3.50615175
19Hematochezia (HP:0002573)3.49111442
20Axonal loss (HP:0003447)3.44404293
21Recurrent gram-negative bacterial infections (HP:0005420)3.42550573
22Cerebral aneurysm (HP:0004944)3.31910859
23Abnormality of polysaccharide metabolism (HP:0011012)3.20875378
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20875378
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20875378
26Urinary glycosaminoglycan excretion (HP:0003541)3.18838075
27Mucopolysacchariduria (HP:0008155)3.18838075
28Mesangial abnormality (HP:0001966)3.18173373
29Vascular tortuosity (HP:0004948)3.16838919
30Autoimmune thrombocytopenia (HP:0001973)3.14438212
31Focal segmental glomerulosclerosis (HP:0000097)3.02665455
32Myocardial infarction (HP:0001658)3.02083427
33Urethral obstruction (HP:0000796)2.99932579
34Purpura (HP:0000979)2.92249854
35Joint hemorrhage (HP:0005261)2.80818710
36Aortic aneurysm (HP:0004942)2.75912013
37Agnosia (HP:0010524)2.71821851
38Amyloidosis (HP:0011034)2.65007299
39Hypoalphalipoproteinemia (HP:0003233)2.63452095
40Hydroxyprolinuria (HP:0003080)2.62380548
41Abnormality of proline metabolism (HP:0010907)2.62380548
42Mutism (HP:0002300)2.61239098
43Abnormality of the periventricular white matter (HP:0002518)2.59710384
44Apathy (HP:0000741)2.58359999
45Abnormality of macrophages (HP:0004311)2.57008274
46Disinhibition (HP:0000734)2.54782638
47Diminished motivation (HP:0000745)2.47515444
48Nuclear cataract (HP:0100018)2.47443844
49Metaphyseal irregularity (HP:0003025)2.47038212
50Personality changes (HP:0000751)2.46971619
51Colitis (HP:0002583)2.44155257
52Tetraparesis (HP:0002273)2.43863219
53Xanthomatosis (HP:0000991)2.42923459
54Conjunctival telangiectasia (HP:0000524)2.36595676
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.35768698
56Recurrent skin infections (HP:0001581)2.34107507
57Chronic diarrhea (HP:0002028)2.33445104
58Global brain atrophy (HP:0002283)2.32106514
59Pathologic fracture (HP:0002756)2.31898687
60Upper motor neuron abnormality (HP:0002127)2.29757490
61Inappropriate behavior (HP:0000719)2.29421899
62Disproportionate tall stature (HP:0001519)2.28423069
63Basal ganglia calcification (HP:0002135)2.26684204
64Peripheral demyelination (HP:0011096)2.23993398
65Neurofibrillary tangles (HP:0002185)2.21188398
66Spontaneous hematomas (HP:0007420)2.18597796
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15658580
68Skin nodule (HP:0200036)2.14746485
69Deep venous thrombosis (HP:0002625)2.13950784
70Glomerulosclerosis (HP:0000096)2.13234002
71Hyperlipoproteinemia (HP:0010980)2.12290462
72Gingivitis (HP:0000230)2.08661309
73Sensorimotor neuropathy (HP:0007141)2.06481485
74Vertebral compression fractures (HP:0002953)2.04945915
75Esophageal varix (HP:0002040)2.03017137
76Beaking of vertebral bodies (HP:0004568)2.02599776
77Thick nail (HP:0001805)2.02043506
78Neuronal loss in central nervous system (HP:0002529)2.01699833
79Clumsiness (HP:0002312)2.01671434
80Bone pain (HP:0002653)1.97914829
81Increased serum ferritin (HP:0003281)1.96397237
82Mediastinal lymphadenopathy (HP:0100721)1.96120376
83Abnormality of the common coagulation pathway (HP:0010990)1.93994518
84Supranuclear gaze palsy (HP:0000605)1.92965785
85Aortic dissection (HP:0002647)1.92783627
86Abnormal albumin level (HP:0012116)1.92455004
87Hypoalbuminemia (HP:0003073)1.92455004
88Hemorrhage of the eye (HP:0011885)1.92186112
89Periodontitis (HP:0000704)1.91216527
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90605634
91Hepatosplenomegaly (HP:0001433)1.89893424
92Aplasia involving bones of the extremities (HP:0009825)1.86863356
93Aplasia involving bones of the upper limbs (HP:0009823)1.86863356
94Aplasia of the phalanges of the hand (HP:0009802)1.86863356
95Increased CSF protein (HP:0002922)1.83682316
96Loss of speech (HP:0002371)1.83556262
97Polygenic inheritance (HP:0010982)1.82843940
98Polycythemia (HP:0001901)1.82092810
99Striae distensae (HP:0001065)1.80632500
100Gingival bleeding (HP:0000225)1.80006299
101Abnormality of the lumbar spine (HP:0100712)1.79421048
102Mitral stenosis (HP:0001718)1.79419792
103Thoracic kyphosis (HP:0002942)1.78951763
104Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78634981
105Recurrent fungal infections (HP:0002841)1.78422003
106Hypolipoproteinemia (HP:0010981)1.76708010
107Asymmetric septal hypertrophy (HP:0001670)1.76271133
108Mitral valve prolapse (HP:0001634)1.76175582
109Progressive neurologic deterioration (HP:0002344)1.76132186
110Prolonged neonatal jaundice (HP:0006579)1.75279194
111Dementia (HP:0000726)1.75153569
112Inflammation of the large intestine (HP:0002037)1.71777503
113Flat acetabular roof (HP:0003180)1.71729125
114Cardiomegaly (HP:0001640)1.69459019
115Vascular calcification (HP:0004934)1.69307867
116Hypercholesterolemia (HP:0003124)1.68388724
117* Progressive visual loss (HP:0000529)1.68043166
118Ovoid vertebral bodies (HP:0003300)1.66723676
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.65719497
120Prolonged partial thromboplastin time (HP:0003645)1.65597439
121Multiple enchondromatosis (HP:0005701)1.65022016
122Spondylolisthesis (HP:0003302)1.64661429
123Osteolytic defects of the hand bones (HP:0009699)1.64658248
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.64658248
125Abnormality of the thoracic spine (HP:0100711)1.63595890
126Arnold-Chiari malformation (HP:0002308)1.62889264
127Hemiplegia (HP:0002301)1.61781670
128Epidermoid cyst (HP:0200040)1.61578758
129Abnormality of iron homeostasis (HP:0011031)1.59349828
130Polyneuropathy (HP:0001271)1.57960117
131Spontaneous abortion (HP:0005268)1.57661102
132Malnutrition (HP:0004395)1.54839518
133Chronic obstructive pulmonary disease (HP:0006510)1.54247638
134Obstructive lung disease (HP:0006536)1.54247638
135Epistaxis (HP:0000421)1.53483475
136Abnormality of the axillary hair (HP:0100134)1.52860728
137Abnormality of secondary sexual hair (HP:0009888)1.52860728
138Abnormality of carpal bone ossification (HP:0006257)1.52838831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.55135304
2IRAK32.89834632
3MAPK152.81298044
4CAMK1D2.63947273
5RIPK42.60234750
6GRK72.59783465
7DDR22.43191569
8TYK22.40475434
9CSF1R2.22211447
10CAMK1G2.21566311
11ACVR1B1.97995290
12ERN11.96428265
13TBK11.90953946
14MAP3K141.87898951
15ICK1.81084482
16NME21.69138429
17PDGFRA1.65815712
18JAK11.64731544
19SIK11.64607723
20MAPK121.62230590
21MAP3K131.56543949
22PRPF4B1.55174600
23PDK21.54148248
24BLK1.53168697
25CDC42BPA1.48239707
26IRAK41.47113509
27TYRO31.36710194
28TNIK1.33259545
29TRIB31.31704759
30PAK41.31071020
31EPHB11.27897483
32KIT1.20199556
33STK101.17636667
34TGFBR11.16931882
35MAPK71.15456079
36MST1R1.13710744
37CDK31.11692134
38IKBKB1.11606942
39MAP3K31.08901373
40MAP4K11.06811352
41JAK21.04477696
42NEK91.03933342
43CSK1.02376976
44ABL21.00636099
45IKBKE0.98801118
46HCK0.97684960
47PTK60.96566741
48MAP2K30.95952008
49FRK0.90955564
50ZAP700.89061322
51INSRR0.89034244
52SGK30.88413029
53CDK120.86650518
54PBK0.85766793
55TIE10.85347649
56FGFR30.84341657
57MARK20.83781960
58LATS20.83446715
59MAP3K10.83236148
60RET0.82166390
61PRKAA20.82013818
62FGR0.81633740
63PDGFRB0.81142736
64EPHA40.80456041
65TAOK30.79415356
66MATK0.79211258
67FES0.78162074
68MOS0.77734102
69SGK20.76918533
70JAK30.76329257
71MAP3K110.75974955
72LYN0.74554947
73WNK40.73920652
74SIK20.73333348
75FGFR40.72204578
76PDPK10.71935261
77MAP3K60.71478963
78ERBB40.70907005
79EPHB20.69335355
80RIPK10.69180087
81AKT30.68302230
82LMTK20.66716243
83TAOK20.64691030
84EGFR0.64441262
85ITK0.64290740
86MARK30.64143836
87CLK10.63541332
88DMPK0.62890503
89PDK10.62426113
90* IGF1R0.61173324
91TRPM70.61048723
92CAMK40.60670916
93LCK0.59915215
94FGFR20.59737833
95DAPK20.59503873
96MAP3K20.59392261
97RPS6KA20.58392349
98PAK20.57062199
99CAMKK20.56788352
100MAP3K50.56551827
101OXSR10.54478875
102CHUK0.54409399
103ARAF0.53902721
104BMX0.53193724
105PIK3CA0.53000028
106FER0.52456359
107TESK20.50477966
108SYK0.49658389
109LATS10.48689851
110TAOK10.48418988
111CDK60.48335392
112GSK3A0.47079693
113CAMKK10.43929827
114KSR20.42336285
115INSR0.42118816
116MAPK110.41922585
117PIK3CG0.41570621
118PRKG20.41077021
119PTK2B0.40737675
120NEK60.40534133
121RPS6KL10.40386755
122RPS6KC10.40386755
123MTOR0.39538042
124MAP3K100.39326062
125MAP2K20.38697108
126MAPK40.38671354
127EIF2AK20.38519233
128GRK10.38503591
129ABL10.38458231
130PKN20.38009445
131NUAK10.37398692
132IRAK20.37057111
133STK390.36687740
134PHKG20.36579777
135PHKG10.36579777
136MET0.35987157
137SRC0.35937025
138MAP3K90.35598043
139ERBB20.34174594
140PRKD10.33869552
141TNK20.31976887
142MELK0.31936223

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.79018876
2Nitrogen metabolism_Homo sapiens_hsa009103.66174702
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.84251847
4Other glycan degradation_Homo sapiens_hsa005112.47444585
5Complement and coagulation cascades_Homo sapiens_hsa046102.28710144
6Lysosome_Homo sapiens_hsa041422.21447570
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88687415
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86524443
9Osteoclast differentiation_Homo sapiens_hsa043801.81788663
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73619329
11Leishmaniasis_Homo sapiens_hsa051401.60613156
12Pertussis_Homo sapiens_hsa051331.55054017
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48822230
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42665970
15ABC transporters_Homo sapiens_hsa020101.41804603
16Caffeine metabolism_Homo sapiens_hsa002321.32006925
17Tuberculosis_Homo sapiens_hsa051521.29335458
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28481903
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28248828
20PPAR signaling pathway_Homo sapiens_hsa033201.26795817
21Mineral absorption_Homo sapiens_hsa049781.22479790
22Prion diseases_Homo sapiens_hsa050201.21034845
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.20552963
24Bile secretion_Homo sapiens_hsa049761.20284844
25Arginine biosynthesis_Homo sapiens_hsa002201.19981985
26Malaria_Homo sapiens_hsa051441.19697929
27Renin-angiotensin system_Homo sapiens_hsa046141.16430418
28Fatty acid biosynthesis_Homo sapiens_hsa000611.14281200
29Antigen processing and presentation_Homo sapiens_hsa046121.07528714
30B cell receptor signaling pathway_Homo sapiens_hsa046621.06849633
31Collecting duct acid secretion_Homo sapiens_hsa049661.04836312
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04819968
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04717279
34Vitamin digestion and absorption_Homo sapiens_hsa049771.01896154
35Fatty acid degradation_Homo sapiens_hsa000711.00005424
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99146629
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96369469
38African trypanosomiasis_Homo sapiens_hsa051430.94126235
39Toxoplasmosis_Homo sapiens_hsa051450.93062636
40Galactose metabolism_Homo sapiens_hsa000520.91616639
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91161993
42Vibrio cholerae infection_Homo sapiens_hsa051100.90420755
43Rheumatoid arthritis_Homo sapiens_hsa053230.89494979
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89086711
45Influenza A_Homo sapiens_hsa051640.87492572
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86869424
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86583077
48Fatty acid metabolism_Homo sapiens_hsa012120.85301000
49Asthma_Homo sapiens_hsa053100.81599692
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81377452
51Legionellosis_Homo sapiens_hsa051340.80740629
52Starch and sucrose metabolism_Homo sapiens_hsa005000.80329468
53Amoebiasis_Homo sapiens_hsa051460.79892784
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79639802
55Chemokine signaling pathway_Homo sapiens_hsa040620.78595187
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73764377
57HIF-1 signaling pathway_Homo sapiens_hsa040660.73100221
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.71886716
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71434809
60Salmonella infection_Homo sapiens_hsa051320.70860929
61Dorso-ventral axis formation_Homo sapiens_hsa043200.70421613
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68625753
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.67344958
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66507385
65Steroid biosynthesis_Homo sapiens_hsa001000.65477376
66Phagosome_Homo sapiens_hsa041450.64604719
67TNF signaling pathway_Homo sapiens_hsa046680.64210248
68Pancreatic cancer_Homo sapiens_hsa052120.64199761
69Measles_Homo sapiens_hsa051620.62295690
70Lysine degradation_Homo sapiens_hsa003100.61468857
71Platelet activation_Homo sapiens_hsa046110.60835872
72Hematopoietic cell lineage_Homo sapiens_hsa046400.60476724
73Bladder cancer_Homo sapiens_hsa052190.60289389
74Ovarian steroidogenesis_Homo sapiens_hsa049130.59543905
75Hepatitis C_Homo sapiens_hsa051600.59483264
76Vitamin B6 metabolism_Homo sapiens_hsa007500.58768261
77Tryptophan metabolism_Homo sapiens_hsa003800.58703432
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57983443
79ECM-receptor interaction_Homo sapiens_hsa045120.55879854
80Allograft rejection_Homo sapiens_hsa053300.55825531
81Sphingolipid metabolism_Homo sapiens_hsa006000.55810191
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.55641090
83Peroxisome_Homo sapiens_hsa041460.55426332
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53518499
85Adherens junction_Homo sapiens_hsa045200.50786725
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50238532
87Histidine metabolism_Homo sapiens_hsa003400.49184585
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.49176375
89Fat digestion and absorption_Homo sapiens_hsa049750.48945412
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.48884879
91Insulin resistance_Homo sapiens_hsa049310.48725868
92Autoimmune thyroid disease_Homo sapiens_hsa053200.47778831
93Chemical carcinogenesis_Homo sapiens_hsa052040.47195348
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.46877754
95Chronic myeloid leukemia_Homo sapiens_hsa052200.45220771
96Protein digestion and absorption_Homo sapiens_hsa049740.45201339
97GnRH signaling pathway_Homo sapiens_hsa049120.44918508
98Rap1 signaling pathway_Homo sapiens_hsa040150.44085366
99Focal adhesion_Homo sapiens_hsa045100.43734111
100Fructose and mannose metabolism_Homo sapiens_hsa000510.43606240
101Salivary secretion_Homo sapiens_hsa049700.42313265
102Glycerolipid metabolism_Homo sapiens_hsa005610.41685260
103Type II diabetes mellitus_Homo sapiens_hsa049300.40295494
104Proteoglycans in cancer_Homo sapiens_hsa052050.39978613
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39029218
106Apoptosis_Homo sapiens_hsa042100.38820183
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38688479
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.38578410
109Endocytosis_Homo sapiens_hsa041440.38417688
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38228710
111Graft-versus-host disease_Homo sapiens_hsa053320.38169722
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.38039534
113Small cell lung cancer_Homo sapiens_hsa052220.37168605
114Ether lipid metabolism_Homo sapiens_hsa005650.36865237
115Notch signaling pathway_Homo sapiens_hsa043300.36604448
116Acute myeloid leukemia_Homo sapiens_hsa052210.35671653
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35291285
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.35121664
119Glutathione metabolism_Homo sapiens_hsa004800.34789851
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33695274
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33619394
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.33383890
123VEGF signaling pathway_Homo sapiens_hsa043700.33276731
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33106702
125Estrogen signaling pathway_Homo sapiens_hsa049150.33046574
126Renal cell carcinoma_Homo sapiens_hsa052110.29714186
127Thyroid hormone synthesis_Homo sapiens_hsa049180.29020073
128Hepatitis B_Homo sapiens_hsa051610.26757873
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22823693
130Viral myocarditis_Homo sapiens_hsa054160.21062770
131beta-Alanine metabolism_Homo sapiens_hsa004100.20893850
132Choline metabolism in cancer_Homo sapiens_hsa052310.20715773

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