MEMO1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.67477730
2cytidine catabolic process (GO:0006216)7.67477730
3cytidine deamination (GO:0009972)7.67477730
4establishment of protein localization to mitochondrial membrane (GO:0090151)7.12112479
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.99360293
6DNA deamination (GO:0045006)6.77590956
7motile cilium assembly (GO:0044458)5.45910546
8proteasome assembly (GO:0043248)5.22907174
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19648429
10chaperone-mediated protein transport (GO:0072321)5.15229017
11fatty acid elongation (GO:0030497)5.01334570
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.79816393
13protein K6-linked ubiquitination (GO:0085020)4.67817369
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37785955
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34780143
16ATP synthesis coupled proton transport (GO:0015986)4.34780143
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.31514730
18protein neddylation (GO:0045116)4.18667251
19pseudouridine synthesis (GO:0001522)4.18103772
20negative regulation of ligase activity (GO:0051352)4.06689058
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.06689058
22positive regulation of interleukin-8 secretion (GO:2000484)4.05313171
23respiratory electron transport chain (GO:0022904)4.01550120
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.97642797
25termination of RNA polymerase III transcription (GO:0006386)3.97642797
26regulation of cellular amino acid metabolic process (GO:0006521)3.94560127
27electron transport chain (GO:0022900)3.94151338
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93404261
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.93203243
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78000241
31centriole assembly (GO:0098534)3.77457656
32regulation of mitochondrial translation (GO:0070129)3.62604936
33eosinophil chemotaxis (GO:0048245)3.60052402
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51528258
35signal peptide processing (GO:0006465)3.49201379
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46782706
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41237563
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41237563
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.41016645
40regulation of retinoic acid receptor signaling pathway (GO:0048385)3.36628534
41monocyte chemotaxis (GO:0002548)3.36526261
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.35227765
43protein complex biogenesis (GO:0070271)3.34789317
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33206606
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33206606
46signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33206606
47regulation of ubiquitin-protein transferase activity (GO:0051438)3.32942028
48replicative senescence (GO:0090399)3.32864051
49positive regulation of ligase activity (GO:0051351)3.29541716
50protein deneddylation (GO:0000338)3.27547584
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.27026019
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27026019
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.20352495
54intestinal epithelial cell development (GO:0060576)3.20236216
55eosinophil migration (GO:0072677)3.20161931
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17580661
57mitochondrial respiratory chain complex assembly (GO:0033108)3.16910804
58regulation of ligase activity (GO:0051340)3.15111709
59histone mRNA metabolic process (GO:0008334)3.15059592
60negative regulation of T cell differentiation in thymus (GO:0033085)3.13213167
61protein targeting to mitochondrion (GO:0006626)3.09834468
62protein localization to mitochondrion (GO:0070585)3.06306242
63intracellular protein transmembrane import (GO:0044743)3.04730409
64negative regulation of B cell proliferation (GO:0030889)3.04703021
65pyrimidine ribonucleoside metabolic process (GO:0046131)3.02884156
66regulation of cellular amine metabolic process (GO:0033238)3.01367355
67protein localization to kinetochore (GO:0034501)3.00908047
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00855472
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00750742
70establishment of protein localization to mitochondrion (GO:0072655)2.99115881
71inner mitochondrial membrane organization (GO:0007007)2.98265105
72CENP-A containing nucleosome assembly (GO:0034080)2.97583444
73positive regulation of actin filament depolymerization (GO:0030836)2.97512220
74chromatin remodeling at centromere (GO:0031055)2.96417698
75pyrimidine nucleoside catabolic process (GO:0046135)2.93981134
76DNA double-strand break processing (GO:0000729)2.93972848
77rRNA modification (GO:0000154)2.88820678
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85865422
79negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.82808446
80negative regulation of protein ubiquitination (GO:0031397)2.82263250
81positive regulation of cell cycle arrest (GO:0071158)2.81751829
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.80955907
83negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.80665341
84postreplication repair (GO:0006301)2.78085303
85mitochondrial DNA replication (GO:0006264)2.77484324
86DNA dealkylation (GO:0035510)2.76473170
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73836349
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72308406
89maturation of SSU-rRNA (GO:0030490)2.71839625
90mitotic sister chromatid segregation (GO:0000070)2.70237891
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69475318
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.69475318
93NADH dehydrogenase complex assembly (GO:0010257)2.69475318
94heterochromatin organization (GO:0070828)2.69091636
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.64748197
96regulation of protein sumoylation (GO:0033233)2.62543481
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.59358907
98spliceosomal snRNP assembly (GO:0000387)2.59133756
99peptidyl-histidine modification (GO:0018202)2.58703980
100sequestering of actin monomers (GO:0042989)2.58687599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.26798500
2E2F7_22180533_ChIP-Seq_HELA_Human4.93950466
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53433765
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.00138068
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.91773295
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73244031
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.53976468
8ELK1_19687146_ChIP-ChIP_HELA_Human2.93792321
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90317609
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82156863
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80302964
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.70903218
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59212946
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51428488
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.48367747
16VDR_23849224_ChIP-Seq_CD4+_Human2.42225717
17DCP1A_22483619_ChIP-Seq_HELA_Human2.31111329
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24936964
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13556769
20EWS_26573619_Chip-Seq_HEK293_Human2.01074851
21FUS_26573619_Chip-Seq_HEK293_Human1.99816804
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97624099
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96816648
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91898130
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90288337
26FOXP3_21729870_ChIP-Seq_TREG_Human1.87191556
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82032813
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.81685895
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81251871
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.77298888
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74487201
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56148350
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55201152
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54707978
35IRF1_19129219_ChIP-ChIP_H3396_Human1.54555459
36MYC_18940864_ChIP-ChIP_HL60_Human1.52912138
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51208608
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50779366
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.50757402
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49090433
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.48852335
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48681434
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48300034
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44669229
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44061245
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.43730948
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36519540
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.35866412
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35782153
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35364239
51HTT_18923047_ChIP-ChIP_STHdh_Human1.31373773
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31222410
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28927831
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28568928
55TTF2_22483619_ChIP-Seq_HELA_Human1.25354695
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.23386686
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23084209
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23084209
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23084209
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.20680551
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20342052
62XRN2_22483619_ChIP-Seq_HELA_Human1.19031450
63GABP_19822575_ChIP-Seq_HepG2_Human1.18365612
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.16934958
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13846675
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.12864294
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11513924
68AR_21572438_ChIP-Seq_LNCaP_Human1.09158693
69GATA1_22025678_ChIP-Seq_K562_Human1.08572709
70VDR_22108803_ChIP-Seq_LS180_Human1.08380341
71ZNF263_19887448_ChIP-Seq_K562_Human1.08344041
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08328902
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07833853
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06317600
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05742852
76ELF5_23300383_ChIP-Seq_T47D_Human1.05075282
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03083835
78AR_21909140_ChIP-Seq_LNCAP_Human1.02150969
79ER_23166858_ChIP-Seq_MCF-7_Human1.01696489
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99085130
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98247144
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97094725
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96747232
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96489188
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95948207
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93623335
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92107811
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89536766
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88121181
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.86889192
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86375370
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86027745
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85206486
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.83174874
95P300_19829295_ChIP-Seq_ESCs_Human0.82016433
96ZNF274_21170338_ChIP-Seq_K562_Hela0.81999217
97KDM5A_27292631_Chip-Seq_BREAST_Human0.81786502
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.81604731
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80128754
100NANOG_19829295_ChIP-Seq_ESCs_Human0.79356608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.84885333
2MP0009379_abnormal_foot_pigmentation3.25299381
3MP0005646_abnormal_pituitary_gland3.11822327
4MP0001529_abnormal_vocalization2.98689887
5MP0001188_hyperpigmentation2.97837962
6MP0003786_premature_aging2.84488352
7MP0005075_abnormal_melanosome_morpholog2.79479921
8MP0010307_abnormal_tumor_latency2.78759147
9MP0002877_abnormal_melanocyte_morpholog2.75046764
10MP0008007_abnormal_cellular_replicative2.72642784
11MP0000566_synostosis2.67899542
12MP0003111_abnormal_nucleus_morphology2.66202498
13MP0010094_abnormal_chromosome_stability2.62834704
14MP0002102_abnormal_ear_morphology2.15378931
15MP0004957_abnormal_blastocyst_morpholog2.13136123
16MP0000647_abnormal_sebaceous_gland1.98455623
17MP0001919_abnormal_reproductive_system1.97911388
18MP0003806_abnormal_nucleotide_metabolis1.97011402
19MP0006035_abnormal_mitochondrial_morpho1.96594229
20MP0009697_abnormal_copulation1.94122045
21MP0000372_irregular_coat_pigmentation1.93455273
22MP0000427_abnormal_hair_cycle1.92174487
23MP0008058_abnormal_DNA_repair1.91784648
24MP0005408_hypopigmentation1.82573738
25MP0005187_abnormal_penis_morphology1.82215802
26MP0002090_abnormal_vision1.76083152
27MP0006292_abnormal_olfactory_placode1.75826618
28MP0003077_abnormal_cell_cycle1.75547292
29MP0005389_reproductive_system_phenotype1.72392104
30MP0009333_abnormal_splenocyte_physiolog1.63439633
31MP0006054_spinal_hemorrhage1.57684557
32MP0005623_abnormal_meninges_morphology1.56588347
33MP0005423_abnormal_somatic_nervous1.56185977
34MP0001905_abnormal_dopamine_level1.51128765
35MP0003693_abnormal_embryo_hatching1.50260601
36MP0002160_abnormal_reproductive_system1.48139057
37MP0004381_abnormal_hair_follicle1.45109890
38MP0006036_abnormal_mitochondrial_physio1.35964789
39MP0002095_abnormal_skin_pigmentation1.34776193
40MP0002234_abnormal_pharynx_morphology1.34467828
41MP0003186_abnormal_redox_activity1.32865669
42MP0003221_abnormal_cardiomyocyte_apopto1.26940981
43MP0001984_abnormal_olfaction1.26225652
44MP0003567_abnormal_fetal_cardiomyocyte1.26059874
45MP0002163_abnormal_gland_morphology1.25183814
46MP0001764_abnormal_homeostasis1.25085091
47MP0006082_CNS_inflammation1.24146314
48MP0010234_abnormal_vibrissa_follicle1.23063651
49MP0005671_abnormal_response_to1.20938234
50MP0001542_abnormal_bone_strength1.17439749
51MP0010386_abnormal_urinary_bladder1.16718167
52MP0002277_abnormal_respiratory_mucosa1.16343944
53MP0008873_increased_physiological_sensi1.12959832
54MP0002796_impaired_skin_barrier1.10971176
55MP0003937_abnormal_limbs/digits/tail_de1.10833363
56MP0002210_abnormal_sex_determination1.09931761
57MP0006072_abnormal_retinal_apoptosis1.07919389
58MP0001186_pigmentation_phenotype1.02626757
59MP0002736_abnormal_nociception_after1.00536554
60MP0000350_abnormal_cell_proliferation1.00111253
61MP0000613_abnormal_salivary_gland0.98542919
62MP0005501_abnormal_skin_physiology0.98228083
63MP0002168_other_aberrant_phenotype0.93103094
64MP0003195_calcinosis0.91809213
65MP0000639_abnormal_adrenal_gland0.90650843
66MP0002938_white_spotting0.89581317
67MP0000653_abnormal_sex_gland0.88841205
68MP0003646_muscle_fatigue0.87835486
69MP0002148_abnormal_hypersensitivity_rea0.87562144
70MP0001881_abnormal_mammary_gland0.86646039
71MP0001293_anophthalmia0.85794210
72MP0001145_abnormal_male_reproductive0.85163865
73MP0005395_other_phenotype0.84493713
74MP0001968_abnormal_touch/_nociception0.83982809
75MP0008875_abnormal_xenobiotic_pharmacok0.83250233
76MP0005647_abnormal_sex_gland0.81196080
77MP0003941_abnormal_skin_development0.81024858
78MP0005165_increased_susceptibility_to0.79676965
79MP0005386_behavior/neurological_phenoty0.79436472
80MP0004924_abnormal_behavior0.79436472
81MP0004142_abnormal_muscle_tone0.79041694
82MP0008932_abnormal_embryonic_tissue0.78712087
83MP0003718_maternal_effect0.78345141
84MP0000358_abnormal_cell_content/0.75544039
85MP0002138_abnormal_hepatobiliary_system0.75288702
86MP0002006_tumorigenesis0.75010789
87MP0005360_urolithiasis0.73999627
88MP0003045_fibrosis0.72348030
89MP0001853_heart_inflammation0.72060896
90MP0005253_abnormal_eye_physiology0.70486302
91MP0001835_abnormal_antigen_presentation0.68228792
92MP0001119_abnormal_female_reproductive0.67915804
93MP0001502_abnormal_circadian_rhythm0.66375388
94MP0000627_abnormal_mammary_gland0.65852054
95MP0009763_increased_sensitivity_to0.64027571
96MP0002751_abnormal_autonomic_nervous0.63486900
97MP0001929_abnormal_gametogenesis0.63046098
98MP0008770_decreased_survivor_rate0.62725628
99MP0004147_increased_porphyrin_level0.62342190
100MP0000631_abnormal_neuroendocrine_gland0.62036139

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.97999279
2Acute necrotizing encephalopathy (HP:0006965)4.41349121
3Acute encephalopathy (HP:0006846)4.10188411
4Increased serum pyruvate (HP:0003542)4.08383355
5Abnormal mitochondria in muscle tissue (HP:0008316)4.02699074
6Renal Fanconi syndrome (HP:0001994)3.95879106
7Oral leukoplakia (HP:0002745)3.77619691
8Mitochondrial inheritance (HP:0001427)3.66589539
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60705324
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60705324
11Abnormality of glycolysis (HP:0004366)3.55800177
12Congenital, generalized hypertrichosis (HP:0004540)3.48198837
13Progressive macrocephaly (HP:0004481)3.43611757
14Cerebral edema (HP:0002181)3.42993476
15Increased hepatocellular lipid droplets (HP:0006565)3.41304462
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.36469420
17Hepatocellular necrosis (HP:0001404)3.35055497
18Increased CSF lactate (HP:0002490)3.34659318
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.28802138
20Meckel diverticulum (HP:0002245)3.20012714
21Abnormality of chromosome stability (HP:0003220)3.12113969
22Abnormality of the preputium (HP:0100587)3.03982778
23Hepatic necrosis (HP:0002605)2.99685885
24Abnormality of the ileum (HP:0001549)2.91807297
25T lymphocytopenia (HP:0005403)2.90650163
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89578229
27Short tibia (HP:0005736)2.83877697
28Chromsome breakage (HP:0040012)2.83084189
29Hypothermia (HP:0002045)2.76191133
303-Methylglutaconic aciduria (HP:0003535)2.69380366
31Microvesicular hepatic steatosis (HP:0001414)2.67710912
32Congenital ichthyosiform erythroderma (HP:0007431)2.66467906
33Hyperphosphaturia (HP:0003109)2.61561009
34Microglossia (HP:0000171)2.61101222
35Lipid accumulation in hepatocytes (HP:0006561)2.59060475
36Exertional dyspnea (HP:0002875)2.55452584
37Abnormality of T cell number (HP:0011839)2.54215309
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.51250896
39Sparse eyelashes (HP:0000653)2.49474203
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48723192
41Abnormality of alanine metabolism (HP:0010916)2.47217954
42Hyperalaninemia (HP:0003348)2.47217954
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47217954
44Duodenal stenosis (HP:0100867)2.45045884
45Small intestinal stenosis (HP:0012848)2.45045884
46Amniotic constriction ring (HP:0009775)2.42691292
47Abnormality of placental membranes (HP:0011409)2.42691292
48Clubbing of toes (HP:0100760)2.40505461
49Septate vagina (HP:0001153)2.38928292
50Abnormality of renal resorption (HP:0011038)2.36983380
51Nasolacrimal duct obstruction (HP:0000579)2.31882599
52Abnormality of the anterior horn cell (HP:0006802)2.23198854
53Degeneration of anterior horn cells (HP:0002398)2.23198854
54Carpal bone hypoplasia (HP:0001498)2.22551867
55Increased intramyocellular lipid droplets (HP:0012240)2.21690762
56Abnormal tarsal ossification (HP:0008369)2.21403844
57Multiple enchondromatosis (HP:0005701)2.21198917
58Acute lymphatic leukemia (HP:0006721)2.20406956
59Type I transferrin isoform profile (HP:0003642)2.19914172
60Pancytopenia (HP:0001876)2.16816308
61Triphalangeal thumb (HP:0001199)2.15968037
62Lactic acidosis (HP:0003128)2.15897638
63Myelodysplasia (HP:0002863)2.11367596
64Prostate neoplasm (HP:0100787)2.08740739
65Exercise intolerance (HP:0003546)2.07266944
66Cutaneous melanoma (HP:0012056)2.06867709
67Delayed epiphyseal ossification (HP:0002663)2.06117125
68Generalized aminoaciduria (HP:0002909)2.05262916
69Bone marrow hypocellularity (HP:0005528)2.04963961
70Increased serum lactate (HP:0002151)2.04641399
71Respiratory failure (HP:0002878)2.02674564
72Sclerocornea (HP:0000647)2.00764549
73Severe combined immunodeficiency (HP:0004430)1.99638658
74Abnormality of the duodenum (HP:0002246)1.97918837
75Microretrognathia (HP:0000308)1.96525624
76Rough bone trabeculation (HP:0100670)1.94832744
77Bifid tongue (HP:0010297)1.94209329
78Abnormal trabecular bone morphology (HP:0100671)1.92161737
79Abnormal urine phosphate concentration (HP:0012599)1.90658604
80Degeneration of the lateral corticospinal tracts (HP:0002314)1.87918190
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87918190
82Hypoalbuminemia (HP:0003073)1.87717708
83Abnormal albumin level (HP:0012116)1.87717708
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.87611227
85Optic disc pallor (HP:0000543)1.85811353
86Combined immunodeficiency (HP:0005387)1.85645610
87Thyroiditis (HP:0100646)1.83951194
88Papillary thyroid carcinoma (HP:0002895)1.83933717
89Lethargy (HP:0001254)1.83195489
90IgG deficiency (HP:0004315)1.80876974
91Methylmalonic acidemia (HP:0002912)1.80864315
92Choanal atresia (HP:0000453)1.80247095
93Testicular atrophy (HP:0000029)1.79261257
94Medial flaring of the eyebrow (HP:0010747)1.77889499
95Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77531699
96Absent radius (HP:0003974)1.76120928
97Unsteady gait (HP:0002317)1.75922399
98Synostosis involving the elbow (HP:0003938)1.75755897
99Humeroradial synostosis (HP:0003041)1.75755897
100Abnormality of midbrain morphology (HP:0002418)1.72080682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.51429708
2NEK13.91112207
3MAP3K123.08510582
4BCKDK2.93828370
5BMPR1B2.82588090
6TESK22.82198691
7ERBB32.78421250
8MAP4K22.78120564
9EIF2AK32.58263624
10VRK22.55293055
11TAF12.51347570
12SRPK12.44208632
13TXK2.31589972
14PNCK2.30129919
15TESK12.14249925
16VRK12.10625868
17TNIK2.10475400
18TNK21.95131181
19NUAK11.83297077
20PBK1.82404491
21WEE11.78578760
22AKT31.76784333
23LIMK11.72028057
24KDR1.63751148
25ACVR1B1.57721299
26MYLK1.56248462
27TAOK31.55072148
28MAP3K131.55048197
29MKNK21.44109893
30ERBB41.41294527
31MAPKAPK31.34144334
32MST41.24814762
33TGFBR11.15690670
34AURKA1.13415680
35DAPK11.08657724
36ARAF1.08153101
37CDK81.03643153
38NME11.03284046
39CDC70.99999247
40MAP2K70.97093934
41DYRK20.95340852
42GRK10.94858131
43TTK0.92079570
44TRIM280.91818882
45PIK3CA0.91198292
46PAK40.90962970
47AURKB0.90441137
48LATS10.89786853
49CCNB10.89148058
50MAP3K90.85617544
51PLK40.84628775
52PRKD30.72690460
53ADRBK20.70902487
54SCYL20.69367427
55GRK50.68569790
56MOS0.67081470
57PLK30.66316075
58CHEK20.63944341
59ATR0.63408296
60MELK0.63375455
61DYRK30.61684812
62CDK70.60693312
63NTRK30.60453743
64PLK10.59619926
65PLK20.59369787
66ZAK0.56828768
67RPS6KA50.54438067
68EPHA20.54370555
69TLK10.54248676
70RPS6KA40.51526848
71NTRK20.50889239
72ILK0.49796678
73DAPK30.48612958
74CSNK1A1L0.48273746
75PDK20.48021955
76STK160.45670269
77MKNK10.45495041
78TYRO30.45299763
79BMPR20.42849169
80MAPK130.42457880
81BRAF0.41635319
82CSNK2A10.38837507
83CSNK1G30.38132341
84BRSK20.35928233
85MINK10.35637750
86NME20.35619355
87CLK10.35594935
88FGFR10.34168053
89CSNK1G10.33264363
90ABL20.31971834
91TSSK60.30884652
92BRD40.27794311
93CSNK1A10.26258855
94PINK10.25358591
95PASK0.25041001
96CSNK2A20.24549026
97CAMK2A0.23447285
98RAF10.22230686
99EIF2AK10.22164634
100NEK20.21440779

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.47205862
2Oxidative phosphorylation_Homo sapiens_hsa001903.71783815
3Parkinsons disease_Homo sapiens_hsa050123.43849250
4Protein export_Homo sapiens_hsa030603.32952091
5RNA polymerase_Homo sapiens_hsa030202.85710384
6Fatty acid elongation_Homo sapiens_hsa000622.63633532
7Ribosome_Homo sapiens_hsa030102.49228679
8Huntingtons disease_Homo sapiens_hsa050162.41182506
9Systemic lupus erythematosus_Homo sapiens_hsa053222.30962801
10Homologous recombination_Homo sapiens_hsa034402.26484454
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25875464
12DNA replication_Homo sapiens_hsa030302.25384058
13Alzheimers disease_Homo sapiens_hsa050102.04379495
14Fanconi anemia pathway_Homo sapiens_hsa034601.99530398
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94028587
16Spliceosome_Homo sapiens_hsa030401.77443889
17RNA transport_Homo sapiens_hsa030131.64566767
18Antigen processing and presentation_Homo sapiens_hsa046121.62746678
19Steroid biosynthesis_Homo sapiens_hsa001001.58944853
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58371712
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58182357
22Alcoholism_Homo sapiens_hsa050341.57450540
23Mismatch repair_Homo sapiens_hsa034301.51843534
24Nucleotide excision repair_Homo sapiens_hsa034201.50132690
25Pyrimidine metabolism_Homo sapiens_hsa002401.47569472
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40315498
27Caffeine metabolism_Homo sapiens_hsa002321.36757891
28Primary immunodeficiency_Homo sapiens_hsa053401.33068105
29Graft-versus-host disease_Homo sapiens_hsa053321.32909213
30Autoimmune thyroid disease_Homo sapiens_hsa053201.29131417
31Propanoate metabolism_Homo sapiens_hsa006401.24767947
32Basal transcription factors_Homo sapiens_hsa030221.22802826
33Non-homologous end-joining_Homo sapiens_hsa034501.20896549
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15632271
35Cell cycle_Homo sapiens_hsa041101.09467554
36Sulfur metabolism_Homo sapiens_hsa009201.05233541
37Allograft rejection_Homo sapiens_hsa053301.02591378
38Cardiac muscle contraction_Homo sapiens_hsa042601.00950968
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99045116
40Fatty acid biosynthesis_Homo sapiens_hsa000610.98257493
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93271853
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92061375
43Purine metabolism_Homo sapiens_hsa002300.88033996
44Type I diabetes mellitus_Homo sapiens_hsa049400.84212782
45Rheumatoid arthritis_Homo sapiens_hsa053230.84198423
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83893886
47RNA degradation_Homo sapiens_hsa030180.81677953
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80688990
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80656061
50Folate biosynthesis_Homo sapiens_hsa007900.79536970
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76939669
52Olfactory transduction_Homo sapiens_hsa047400.75740301
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.71068049
54p53 signaling pathway_Homo sapiens_hsa041150.70164788
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69895868
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69265804
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68161614
58Fatty acid metabolism_Homo sapiens_hsa012120.66459014
59Regulation of autophagy_Homo sapiens_hsa041400.64964676
60Tryptophan metabolism_Homo sapiens_hsa003800.63922056
61Pyruvate metabolism_Homo sapiens_hsa006200.63168278
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.61528529
63Viral carcinogenesis_Homo sapiens_hsa052030.59617437
64Epstein-Barr virus infection_Homo sapiens_hsa051690.59286809
65Selenocompound metabolism_Homo sapiens_hsa004500.59185645
66Hematopoietic cell lineage_Homo sapiens_hsa046400.58803838
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56882678
68Metabolic pathways_Homo sapiens_hsa011000.55515623
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55179153
70Viral myocarditis_Homo sapiens_hsa054160.55170737
71Base excision repair_Homo sapiens_hsa034100.53325529
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52124399
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51763497
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51330459
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48615581
76Fatty acid degradation_Homo sapiens_hsa000710.46815070
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46236196
78mRNA surveillance pathway_Homo sapiens_hsa030150.45812003
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44341266
80Oocyte meiosis_Homo sapiens_hsa041140.43176276
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42769265
82Glutathione metabolism_Homo sapiens_hsa004800.42665735
83Asthma_Homo sapiens_hsa053100.42495358
84Sulfur relay system_Homo sapiens_hsa041220.40524011
85Salmonella infection_Homo sapiens_hsa051320.39503582
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38169687
87Circadian rhythm_Homo sapiens_hsa047100.37960780
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34269850
89Arginine and proline metabolism_Homo sapiens_hsa003300.34228416
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33851702
91Biosynthesis of amino acids_Homo sapiens_hsa012300.33172349
92Taste transduction_Homo sapiens_hsa047420.31780770
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31599959
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.29961056
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28757381
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26394865
97N-Glycan biosynthesis_Homo sapiens_hsa005100.26216927
98beta-Alanine metabolism_Homo sapiens_hsa004100.23431900
99Carbon metabolism_Homo sapiens_hsa012000.22412691
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22082548

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