MELK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.51872117
2mitotic metaphase plate congression (GO:0007080)5.26298069
3mitotic chromosome condensation (GO:0007076)4.92102883
4DNA unwinding involved in DNA replication (GO:0006268)4.90905719
5protein localization to chromosome, centromeric region (GO:0071459)4.74876500
6kinetochore organization (GO:0051383)4.71882886
7mitotic sister chromatid segregation (GO:0000070)4.68900229
8metaphase plate congression (GO:0051310)4.68145058
9establishment of integrated proviral latency (GO:0075713)4.67272479
10DNA strand elongation involved in DNA replication (GO:0006271)4.66499112
11DNA replication initiation (GO:0006270)4.61458887
12CENP-A containing nucleosome assembly (GO:0034080)4.52651636
13attachment of spindle microtubules to kinetochore (GO:0008608)4.52183551
14chromatin remodeling at centromere (GO:0031055)4.50616792
15nuclear pore organization (GO:0006999)4.44795889
16DNA replication checkpoint (GO:0000076)4.44014239
17DNA strand elongation (GO:0022616)4.42469976
18sister chromatid segregation (GO:0000819)4.39090082
19regulation of spindle organization (GO:0090224)4.35793979
20DNA replication-dependent nucleosome assembly (GO:0006335)4.34928018
21DNA replication-dependent nucleosome organization (GO:0034723)4.34928018
22mitotic nuclear envelope disassembly (GO:0007077)4.28443114
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22698744
24telomere maintenance via semi-conservative replication (GO:0032201)4.22180726
25establishment of chromosome localization (GO:0051303)4.21750960
26kinetochore assembly (GO:0051382)4.15966617
27nuclear pore complex assembly (GO:0051292)4.15651645
28DNA replication-independent nucleosome organization (GO:0034724)4.14295910
29DNA replication-independent nucleosome assembly (GO:0006336)4.14295910
30DNA ligation (GO:0006266)4.08500719
31nuclear envelope disassembly (GO:0051081)3.98717250
32membrane disassembly (GO:0030397)3.98717250
33mitotic recombination (GO:0006312)3.96438133
34telomere maintenance via recombination (GO:0000722)3.93091470
35regulation of mitotic spindle organization (GO:0060236)3.88551564
36histone exchange (GO:0043486)3.87785934
37spindle checkpoint (GO:0031577)3.83273178
38nucleobase biosynthetic process (GO:0046112)3.81551718
39meiotic chromosome segregation (GO:0045132)3.80273232
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80168625
41DNA topological change (GO:0006265)3.78008292
42regulation of chromosome segregation (GO:0051983)3.76525311
43positive regulation of chromosome segregation (GO:0051984)3.72727968
44negative regulation of chromosome segregation (GO:0051985)3.70160258
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.66871307
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.66871307
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.66871307
48negative regulation of sister chromatid segregation (GO:0033046)3.66871307
49spindle assembly checkpoint (GO:0071173)3.66342328
50establishment of viral latency (GO:0019043)3.64415370
51protein localization to chromosome (GO:0034502)3.64101004
52telomere maintenance via telomere lengthening (GO:0010833)3.61446348
53regulation of sister chromatid cohesion (GO:0007063)3.60549528
54formation of translation preinitiation complex (GO:0001731)3.60292437
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.59237403
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.58998053
57mitotic spindle assembly checkpoint (GO:0007094)3.58830145
58regulation of DNA endoreduplication (GO:0032875)3.58706880
59purine nucleobase biosynthetic process (GO:0009113)3.58226382
60microtubule depolymerization (GO:0007019)3.57236021
61mitotic spindle checkpoint (GO:0071174)3.57066296
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.53327023
63maturation of SSU-rRNA (GO:0030490)3.53288701
64folic acid-containing compound biosynthetic process (GO:0009396)3.52856089
65chromosome segregation (GO:0007059)3.52221816
66regulation of centrosome cycle (GO:0046605)3.50222389
67proteasome assembly (GO:0043248)3.48439728
68ribosome assembly (GO:0042255)3.43792898
69regulation of sister chromatid segregation (GO:0033045)3.41558142
70regulation of mitotic sister chromatid separation (GO:0010965)3.41558142
71regulation of mitotic sister chromatid segregation (GO:0033047)3.41558142
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.40517759
73IMP biosynthetic process (GO:0006188)3.40317775
74chromatin assembly or disassembly (GO:0006333)3.38929008
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38227541
76DNA geometric change (GO:0032392)3.35082472
77DNA duplex unwinding (GO:0032508)3.34553433
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32994941
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32994941
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.32994941
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32655651
82protein K6-linked ubiquitination (GO:0085020)3.32081881
83ventricular cardiac muscle cell development (GO:0055015)3.31709608
84chromosome condensation (GO:0030261)3.31608331
85non-recombinational repair (GO:0000726)3.29500247
86double-strand break repair via nonhomologous end joining (GO:0006303)3.29500247
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27375832
88mitotic G2/M transition checkpoint (GO:0044818)3.26294994
89mitotic sister chromatid cohesion (GO:0007064)3.24049419
90regulation of double-strand break repair via homologous recombination (GO:0010569)3.23030067
91spindle assembly involved in mitosis (GO:0090307)3.22495338
92deoxyribonucleotide biosynthetic process (GO:0009263)3.22369510
93pore complex assembly (GO:0046931)3.20914574
94heterochromatin organization (GO:0070828)3.20570598
95regulation of centriole replication (GO:0046599)3.15610722
96ATP-dependent chromatin remodeling (GO:0043044)3.14716514
97ribosomal large subunit biogenesis (GO:0042273)3.13569545
98G1/S transition of mitotic cell cycle (GO:0000082)3.10796674
99cell cycle G1/S phase transition (GO:0044843)3.10796674
100mitotic spindle organization (GO:0007052)3.10733351
101somatic hypermutation of immunoglobulin genes (GO:0016446)3.10403626
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10403626
103ribosome biogenesis (GO:0042254)3.09564749
104nuclear envelope organization (GO:0006998)3.09560606
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07459557
106DNA conformation change (GO:0071103)3.04882997
107regulation of posttranscriptional gene silencing (GO:0060147)3.03519348
108regulation of gene silencing by miRNA (GO:0060964)3.03519348
109regulation of gene silencing by RNA (GO:0060966)3.03519348
110negative regulation of ligase activity (GO:0051352)3.03328557
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03328557
112mitotic cell cycle (GO:0000278)3.03198311
113DNA packaging (GO:0006323)2.98989201
114IMP metabolic process (GO:0046040)2.98120347
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97496175
116spliceosomal snRNP assembly (GO:0000387)2.97083581
117mismatch repair (GO:0006298)2.96811581
118ribonucleoprotein complex biogenesis (GO:0022613)2.95205031
119negative regulation of mitosis (GO:0045839)2.90606977
120telomere organization (GO:0032200)2.90555526
121telomere maintenance (GO:0000723)2.90401176
122ribosomal small subunit assembly (GO:0000028)2.83639715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81120656
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.92859645
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.38415857
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.12538889
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.91996883
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18547531
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03882819
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85948799
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75876297
10* AR_21909140_ChIP-Seq_LNCAP_Human2.71971066
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.62579491
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56057944
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50734678
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47735050
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44889895
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.39998177
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.31148647
18XRN2_22483619_ChIP-Seq_HELA_Human2.26925457
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.25087951
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22690507
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21673287
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21474462
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18398276
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13341696
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.10377790
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91573407
27VDR_23849224_ChIP-Seq_CD4+_Human1.91535752
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90764372
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90741725
30DCP1A_22483619_ChIP-Seq_HELA_Human1.82182535
31TTF2_22483619_ChIP-Seq_HELA_Human1.76880316
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74469584
33FOXP3_21729870_ChIP-Seq_TREG_Human1.69858811
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67719381
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65403379
36* GABP_19822575_ChIP-Seq_HepG2_Human1.60842754
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60190454
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59386444
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57089839
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54549496
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54128594
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52467735
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48820776
44ELK1_19687146_ChIP-ChIP_HELA_Human1.48753229
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47455335
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.44369875
47CIITA_25753668_ChIP-Seq_RAJI_Human1.44354794
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.44307961
49* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43262964
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43079707
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42552551
52KDM5A_27292631_Chip-Seq_BREAST_Human1.41226525
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39251144
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36609221
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34456551
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30221378
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28600081
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27354043
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26301946
60MYC_22102868_ChIP-Seq_BL_Human1.25802286
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22831249
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22215100
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21220936
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.20163512
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18468210
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18191372
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17905165
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17564332
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16816817
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16682470
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14380433
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14380433
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14380433
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13423951
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10794731
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10668793
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10038880
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08500780
79TFEB_21752829_ChIP-Seq_HELA_Human1.05952502
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.05565863
81* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04733170
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02497982
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01100402
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99519148
85MYC_18940864_ChIP-ChIP_HL60_Human0.97466689
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95920843
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94940405
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.93769322
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93420507
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92545939
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92416026
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.92400475
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91252973
94TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90163635
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89261954
96* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88016389
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87921919
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86147858
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84443579
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83218133
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83155283
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82605016
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80382648
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.79476071
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78918850
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.78373848
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77014263
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76999471
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75412044
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73992420
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.71690369
112EWS_26573619_Chip-Seq_HEK293_Human0.69622992
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69273754
114CHD1_26751641_Chip-Seq_LNCaP_Human0.68611768
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.65489277
116ZNF263_19887448_ChIP-Seq_K562_Human0.64494587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38944719
2MP0010094_abnormal_chromosome_stability4.82609039
3MP0003111_abnormal_nucleus_morphology4.74819619
4MP0004957_abnormal_blastocyst_morpholog4.51395524
5MP0003077_abnormal_cell_cycle4.15825400
6MP0008057_abnormal_DNA_replication3.56141200
7MP0008058_abnormal_DNA_repair3.04918829
8MP0003123_paternal_imprinting2.87725266
9MP0008932_abnormal_embryonic_tissue2.85965600
10MP0008007_abnormal_cellular_replicative2.67947730
11MP0009697_abnormal_copulation2.56993731
12MP0001730_embryonic_growth_arrest2.56971779
13MP0000350_abnormal_cell_proliferation2.35095776
14MP0010352_gastrointestinal_tract_polyps2.26767537
15MP0008877_abnormal_DNA_methylation2.24622116
16MP0005380_embryogenesis_phenotype2.01360764
17MP0001672_abnormal_embryogenesis/_devel2.01360764
18MP0010307_abnormal_tumor_latency1.99893970
19MP0010030_abnormal_orbit_morphology1.98408993
20MP0001697_abnormal_embryo_size1.93762056
21MP0003718_maternal_effect1.90706807
22MP0002085_abnormal_embryonic_tissue1.83973513
23MP0003984_embryonic_growth_retardation1.76899973
24MP0002088_abnormal_embryonic_growth/wei1.73792847
25MP0002084_abnormal_developmental_patter1.73726868
26MP0003121_genomic_imprinting1.70714863
27MP0003950_abnormal_plasma_membrane1.70674856
28MP0003786_premature_aging1.68525608
29MP0003890_abnormal_embryonic-extraembry1.67607961
30MP0003315_abnormal_perineum_morphology1.66288244
31MP0002080_prenatal_lethality1.65935035
32MP0005076_abnormal_cell_differentiation1.64608931
33MP0002877_abnormal_melanocyte_morpholog1.62805243
34MP0004197_abnormal_fetal_growth/weight/1.56548557
35MP0002086_abnormal_extraembryonic_tissu1.56393021
36MP0003567_abnormal_fetal_cardiomyocyte1.49115869
37MP0000537_abnormal_urethra_morphology1.48412981
38MP0009053_abnormal_anal_canal1.46078902
39MP0002396_abnormal_hematopoietic_system1.41605589
40MP0000490_abnormal_crypts_of1.39239881
41MP0001293_anophthalmia1.35414859
42MP0000313_abnormal_cell_death1.34616057
43MP0002210_abnormal_sex_determination1.33688065
44MP0003941_abnormal_skin_development1.31583939
45MP0003119_abnormal_digestive_system1.31375184
46MP0003705_abnormal_hypodermis_morpholog1.30338088
47MP0003937_abnormal_limbs/digits/tail_de1.26187930
48MP0002019_abnormal_tumor_incidence1.22152218
49MP0001145_abnormal_male_reproductive1.16520435
50MP0005623_abnormal_meninges_morphology1.07379941
51MP0003806_abnormal_nucleotide_metabolis1.06639852
52MP0002111_abnormal_tail_morphology1.05478915
53MP0004808_abnormal_hematopoietic_stem1.03052834
54MP0000653_abnormal_sex_gland1.01940531
55MP0001929_abnormal_gametogenesis1.00675174
56MP0004133_heterotaxia0.99434771
57MP0009672_abnormal_birth_weight0.99197480
58MP0002234_abnormal_pharynx_morphology0.98516035
59MP0002653_abnormal_ependyma_morphology0.97684197
60MP0006035_abnormal_mitochondrial_morpho0.97026899
61MP0002233_abnormal_nose_morphology0.96661895
62MP0001346_abnormal_lacrimal_gland0.96053189
63MP0001119_abnormal_female_reproductive0.92323664
64MP0002160_abnormal_reproductive_system0.91794894
65MP0006292_abnormal_olfactory_placode0.89403598
66MP0000428_abnormal_craniofacial_morphol0.86824148
67MP0008789_abnormal_olfactory_epithelium0.86620319
68MP0000647_abnormal_sebaceous_gland0.86366828
69MP0001286_abnormal_eye_development0.84788537
70MP0005501_abnormal_skin_physiology0.84223909
71MP0000762_abnormal_tongue_morphology0.84171623
72MP0001915_intracranial_hemorrhage0.83472075
73MP0005408_hypopigmentation0.83058203
74MP0004233_abnormal_muscle_weight0.82466222
75MP0001299_abnormal_eye_distance/0.82423579
76MP0009703_decreased_birth_body0.81263624
77MP0003283_abnormal_digestive_organ0.80851461
78MP0005389_reproductive_system_phenotype0.80258973
79MP0005023_abnormal_wound_healing0.80044652
80MP0001849_ear_inflammation0.79960795
81MP0000432_abnormal_head_morphology0.79853672
82MP0004272_abnormal_basement_membrane0.79843489
83MP0003115_abnormal_respiratory_system0.78980560
84MP0003566_abnormal_cell_adhesion0.78924882
85MP0002092_abnormal_eye_morphology0.78679058
86MP0003136_yellow_coat_color0.78336184
87MP0002102_abnormal_ear_morphology0.78048927
88MP0004185_abnormal_adipocyte_glucose0.76934911
89MP0006054_spinal_hemorrhage0.76093801
90MP0000579_abnormal_nail_morphology0.76009089
91MP0005384_cellular_phenotype0.75884750
92MP0005621_abnormal_cell_physiology0.73216696
93MP0003755_abnormal_palate_morphology0.72614833
94MP0000703_abnormal_thymus_morphology0.72023347
95MP0009333_abnormal_splenocyte_physiolog0.71912909
96MP0003385_abnormal_body_wall0.71034485
97MP0000566_synostosis0.70564550
98MP0002697_abnormal_eye_size0.70015551
99MP0003186_abnormal_redox_activity0.69612052
100MP0003935_abnormal_craniofacial_develop0.68237725
101MP0003943_abnormal_hepatobiliary_system0.67750073
102MP0003861_abnormal_nervous_system0.66080474
103MP0005257_abnormal_intraocular_pressure0.65647650
104MP0000627_abnormal_mammary_gland0.65555921
105MP0002938_white_spotting0.65059307
106MP0001727_abnormal_embryo_implantation0.64781076
107MP0002932_abnormal_joint_morphology0.64518942
108MP0000358_abnormal_cell_content/0.64242488
109MP0000733_abnormal_muscle_development0.64226433
110MP0001545_abnormal_hematopoietic_system0.63188130
111MP0005397_hematopoietic_system_phenotyp0.63188130
112MP0003221_abnormal_cardiomyocyte_apopto0.62660011
113MP0004264_abnormal_extraembryonic_tissu0.61477621
114MP0001661_extended_life_span0.61195466
115MP0002796_impaired_skin_barrier0.60180663
116MP0002161_abnormal_fertility/fecundity0.60047398
117MP0003942_abnormal_urinary_system0.59548165
118MP0003699_abnormal_female_reproductive0.59217195
119MP0000858_altered_metastatic_potential0.58780504
120MP0002925_abnormal_cardiovascular_devel0.58458888
121MP0000477_abnormal_intestine_morphology0.58428503
122MP0003936_abnormal_reproductive_system0.58277412
123MP0009278_abnormal_bone_marrow0.57599403
124MP0002282_abnormal_trachea_morphology0.57424221
125MP0005395_other_phenotype0.55877991
126MP0001919_abnormal_reproductive_system0.55738680
127MP0003938_abnormal_ear_development0.55380290
128MP0002114_abnormal_axial_skeleton0.55065432
129MP0000049_abnormal_middle_ear0.54062876

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.68426150
2Chromsome breakage (HP:0040012)4.21662434
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03447143
4Breast hypoplasia (HP:0003187)3.97290034
5Reticulocytopenia (HP:0001896)3.63714272
6Patellar aplasia (HP:0006443)3.61969963
7Colon cancer (HP:0003003)3.59014538
8Absent radius (HP:0003974)3.43131741
9Aplasia/Hypoplasia of the patella (HP:0006498)3.38997486
10Meckel diverticulum (HP:0002245)3.36972313
11Selective tooth agenesis (HP:0001592)3.32850925
12Abnormality of chromosome stability (HP:0003220)3.30777892
13Ependymoma (HP:0002888)3.26160238
14Abnormality of the labia minora (HP:0012880)3.23312828
15Carpal bone hypoplasia (HP:0001498)3.23259736
16Aplasia involving forearm bones (HP:0009822)3.21792122
17Absent forearm bone (HP:0003953)3.21792122
18Abnormality of the ileum (HP:0001549)3.18214093
19Oral leukoplakia (HP:0002745)3.16963164
20Cortical dysplasia (HP:0002539)3.15785309
21Impulsivity (HP:0100710)3.14021995
22Abnormality of the preputium (HP:0100587)3.09836848
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.08717591
24Medulloblastoma (HP:0002885)3.06840481
25Duodenal stenosis (HP:0100867)3.00606352
26Small intestinal stenosis (HP:0012848)3.00606352
27Abnormal lung lobation (HP:0002101)2.95076457
28Rhabdomyosarcoma (HP:0002859)2.85757526
29Supernumerary spleens (HP:0009799)2.83177496
30Abnormality of the anterior horn cell (HP:0006802)2.80049947
31Degeneration of anterior horn cells (HP:0002398)2.80049947
32Absent thumb (HP:0009777)2.79534575
33Increased nuchal translucency (HP:0010880)2.79522357
34Rough bone trabeculation (HP:0100670)2.66201834
35Agnosia (HP:0010524)2.64787579
36Ectopic kidney (HP:0000086)2.61205260
37Neoplasm of the pancreas (HP:0002894)2.59689688
38Horseshoe kidney (HP:0000085)2.55713194
39Clubbing of toes (HP:0100760)2.55119128
40Facial hemangioma (HP:0000329)2.54859389
41Proximal placement of thumb (HP:0009623)2.54780857
42Abnormality of the duodenum (HP:0002246)2.51260377
43Deviation of the thumb (HP:0009603)2.50059857
44Myelodysplasia (HP:0002863)2.47218033
45Abnormal number of incisors (HP:0011064)2.46846585
46Atresia of the external auditory canal (HP:0000413)2.43232877
47Sloping forehead (HP:0000340)2.40077157
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34087018
49Tracheoesophageal fistula (HP:0002575)2.31995657
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.31787169
51Nephroblastoma (Wilms tumor) (HP:0002667)2.30703483
52Abnormality of glycolysis (HP:0004366)2.25604643
53Triphalangeal thumb (HP:0001199)2.23457024
54Biliary tract neoplasm (HP:0100574)2.23314725
55Duplicated collecting system (HP:0000081)2.21433334
56Abnormality of cells of the erythroid lineage (HP:0012130)2.20979319
57Trismus (HP:0000211)2.19229127
58Short thumb (HP:0009778)2.18676881
59Bone marrow hypocellularity (HP:0005528)2.17568546
60Abnormality of the astrocytes (HP:0100707)2.16236901
61Astrocytoma (HP:0009592)2.16236901
62Volvulus (HP:0002580)2.16125928
63Embryonal renal neoplasm (HP:0011794)2.16028587
64Abnormality of abdominal situs (HP:0011620)2.15723238
65Abdominal situs inversus (HP:0003363)2.15723238
66Cafe-au-lait spot (HP:0000957)2.15505664
67Neoplasm of the colon (HP:0100273)2.14116436
68Premature graying of hair (HP:0002216)2.13643703
69Abnormality of the carotid arteries (HP:0005344)2.12456362
70Aplasia/hypoplasia of the humerus (HP:0006507)2.10401129
71Neoplasm of striated muscle (HP:0009728)2.09793279
7211 pairs of ribs (HP:0000878)2.09569277
73Increased serum pyruvate (HP:0003542)2.09262369
74Arteriovenous malformation (HP:0100026)2.07655625
75Duplication of thumb phalanx (HP:0009942)2.06066680
76Abnormality of the umbilical cord (HP:0010881)2.05310410
77Cellular immunodeficiency (HP:0005374)2.04106775
78Microglossia (HP:0000171)2.02868462
79Glioma (HP:0009733)2.02397421
80Abnormality of the fetal cardiovascular system (HP:0010948)2.01383431
81Abnormal umbilical cord blood vessels (HP:0011403)2.01383431
82Single umbilical artery (HP:0001195)2.01383431
83Short 4th metacarpal (HP:0010044)2.00149561
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00149561
85Cleft eyelid (HP:0000625)1.99509582
86Premature ovarian failure (HP:0008209)1.99371828
87Missing ribs (HP:0000921)1.99029070
88Basal cell carcinoma (HP:0002671)1.97549660
89Abnormal number of erythroid precursors (HP:0012131)1.96935991
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96427342
91Cerebral hypomyelination (HP:0006808)1.96211837
92Macrocytic anemia (HP:0001972)1.95131783
93Abnormal trabecular bone morphology (HP:0100671)1.94840353
94Facial cleft (HP:0002006)1.94477690
95Overlapping toe (HP:0001845)1.93834774
96Oligodactyly (HP:0012165)1.93606323
97Embryonal neoplasm (HP:0002898)1.93312953
98Ovarian neoplasm (HP:0100615)1.92031627
99Squamous cell carcinoma (HP:0002860)1.90064446
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89062869
101Abnormality of the renal collecting system (HP:0004742)1.88290368
102Hypoplastic pelvis (HP:0008839)1.87626339
103Ureteral duplication (HP:0000073)1.87287931
104Microvesicular hepatic steatosis (HP:0001414)1.87043627
105Malignant gastrointestinal tract tumors (HP:0006749)1.86215464
106Gastrointestinal carcinoma (HP:0002672)1.86215464
107Multiple enchondromatosis (HP:0005701)1.85333552
108Microretrognathia (HP:0000308)1.84335982
109Neoplasm of the oral cavity (HP:0100649)1.83854619
110Shawl scrotum (HP:0000049)1.82079082
111Stenosis of the external auditory canal (HP:0000402)1.81323184
112Pallor (HP:0000980)1.81231469
113High pitched voice (HP:0001620)1.80061757
114Choanal atresia (HP:0000453)1.78987796
115Aplastic anemia (HP:0001915)1.78397466
116Breast aplasia (HP:0100783)1.78361172
117Deep philtrum (HP:0002002)1.77823969
118Abnormality of DNA repair (HP:0003254)1.73342145
119Poikiloderma (HP:0001029)1.70923321
120Abnormality of chromosome segregation (HP:0002916)1.68704395
121Leiomyosarcoma (HP:0100243)1.67380006
122Uterine leiomyosarcoma (HP:0002891)1.67380006
123Abnormalities of placenta or umbilical cord (HP:0001194)1.62096099
124Capillary hemangiomas (HP:0005306)1.59442039
125Abnormality of the septum pellucidum (HP:0007375)1.58789818
126Abnormality of methionine metabolism (HP:0010901)1.57652243
127Secondary amenorrhea (HP:0000869)1.57587626
128Pancytopenia (HP:0001876)1.56820704
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56753565
130Absent epiphyses (HP:0010577)1.56753565
131Absent septum pellucidum (HP:0001331)1.55264389
132Ankle contracture (HP:0006466)1.54866571
133Sparse eyelashes (HP:0000653)1.53648400
134Uterine neoplasm (HP:0010784)1.53491148
135Abnormality of cochlea (HP:0000375)1.53185193
136Abnormal auditory evoked potentials (HP:0006958)1.52720277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.90683878
2CDC74.61732895
3WEE14.52580812
4NEK23.41717008
5TTK3.27871387
6NEK13.11482101
7EIF2AK12.84823163
8VRK22.56690628
9PLK42.52401763
10SRPK12.41221474
11PLK12.41049427
12BRSK22.29999127
13AURKB1.99895983
14CDK121.99309948
15ACVR1B1.88539147
16PLK31.83340992
17TSSK61.76739886
18TLK11.73353266
19CDK71.68030359
20CHEK21.67451014
21PASK1.66657264
22ATR1.66299226
23MAP3K81.63930575
24MKNK11.63046604
25TAF11.60738568
26BRSK11.59102270
27STK101.51977793
28MST41.50132134
29EPHA21.46959402
30RPS6KB21.46109375
31TESK21.43688540
32AURKA1.41931775
33RPS6KA41.41691946
34MST1R1.39183523
35CDK41.36022913
36CHEK11.35717528
37CCNB11.33681250
38VRK11.31727934
39STK41.29779764
40DYRK31.29106637
41EIF2AK31.28879474
42TRIM281.22145866
43NME21.20346750
44PAK41.17956632
45MKNK21.17086312
46ERBB41.16445111
47EEF2K1.13626354
48STK38L1.12267312
49TGFBR11.04684542
50SMG11.03843032
51ATM0.99980581
52ZAK0.99438184
53STK30.97064976
54LATS20.95635095
55CDK60.94988608
56PBK0.94490573
57BRAF0.92582733
58CDK20.91600168
59BRD40.91139113
60SCYL20.89602692
61LATS10.87173708
62MAP3K100.85880925
63STK160.79958832
64CDK10.75448377
65PNCK0.74366411
66ALK0.73464943
67BCR0.70498138
68EIF2AK20.70404876
69PAK10.70260277
70PIM10.69645696
71NUAK10.69514347
72NME10.62804456
73PDK20.61196842
74CDK80.59827713
75PKN20.58340211
76CSNK2A20.56197366
77CSNK2A10.55781490
78LRRK20.51716856
79PRKCI0.51208952
80TESK10.50377589
81CDK180.50031622
82RPS6KA50.45234034
83PLK20.45069949
84MTOR0.44504335
85BMPR1B0.43464284
86CDK140.42011136
87CLK10.41876019
88PTK20.39305761
89AKT20.39205051
90PRKDC0.39020430
91TNIK0.38781377
92CSNK1E0.37368476
93FLT30.36593455
94ERBB30.34828223
95NEK90.28602086
96CSNK1D0.28425137
97MARK30.28056168
98MAP3K90.27602125
99CSNK1G10.27490561
100CDK90.27250920
101FGFR10.26531788
102DAPK10.25177188
103DYRK20.24813206
104CSNK1G30.24469351
105MAPK140.24447848
106AKT10.23714003
107STK390.22604552
108AKT30.22603082
109PDK40.22374451
110PDK30.22374451
111CSNK1A1L0.21597915
112LIMK10.21097168
113PAK20.18318948
114RPS6KA10.18209045
115* MELK0.18146717
116KSR10.17831850
117KDR0.17277934
118MAP3K110.17257375
119GSK3B0.17129209
120TTN0.16096548
121CDK11A0.15526739
122MAPK10.15517650
123MET0.14754069
124CDK150.14661941

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07530770
2Mismatch repair_Homo sapiens_hsa034304.47781446
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59700490
4RNA transport_Homo sapiens_hsa030133.34296537
5Cell cycle_Homo sapiens_hsa041103.33616780
6Homologous recombination_Homo sapiens_hsa034403.28420843
7Spliceosome_Homo sapiens_hsa030403.28205405
8Base excision repair_Homo sapiens_hsa034103.13747342
9RNA polymerase_Homo sapiens_hsa030202.89372675
10Nucleotide excision repair_Homo sapiens_hsa034202.89025765
11One carbon pool by folate_Homo sapiens_hsa006702.80222393
12Proteasome_Homo sapiens_hsa030502.77457699
13Ribosome_Homo sapiens_hsa030102.71435334
14Fanconi anemia pathway_Homo sapiens_hsa034602.54707317
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36640895
16Pyrimidine metabolism_Homo sapiens_hsa002402.25496661
17Non-homologous end-joining_Homo sapiens_hsa034502.17168769
18Basal transcription factors_Homo sapiens_hsa030221.97354400
19mRNA surveillance pathway_Homo sapiens_hsa030151.93176118
20RNA degradation_Homo sapiens_hsa030181.92633515
21p53 signaling pathway_Homo sapiens_hsa041151.86078238
22Systemic lupus erythematosus_Homo sapiens_hsa053221.43110289
23Oocyte meiosis_Homo sapiens_hsa041141.41846963
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39223851
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30775973
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27166189
27Pyruvate metabolism_Homo sapiens_hsa006201.26625846
28Epstein-Barr virus infection_Homo sapiens_hsa051691.22462642
29Purine metabolism_Homo sapiens_hsa002301.16181489
30Viral carcinogenesis_Homo sapiens_hsa052031.11845745
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97893341
32Steroid biosynthesis_Homo sapiens_hsa001000.97619675
33MicroRNAs in cancer_Homo sapiens_hsa052060.93978858
34Herpes simplex infection_Homo sapiens_hsa051680.89761360
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89737058
36HTLV-I infection_Homo sapiens_hsa051660.89261465
37Fatty acid elongation_Homo sapiens_hsa000620.87830718
38Hippo signaling pathway_Homo sapiens_hsa043900.83572858
39N-Glycan biosynthesis_Homo sapiens_hsa005100.83111166
40Vitamin B6 metabolism_Homo sapiens_hsa007500.81921437
41Propanoate metabolism_Homo sapiens_hsa006400.80172102
42Biosynthesis of amino acids_Homo sapiens_hsa012300.79883220
43Small cell lung cancer_Homo sapiens_hsa052220.79265697
44Basal cell carcinoma_Homo sapiens_hsa052170.78986853
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.76181374
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75235424
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73182552
48Parkinsons disease_Homo sapiens_hsa050120.72766285
49Antigen processing and presentation_Homo sapiens_hsa046120.72557597
50TGF-beta signaling pathway_Homo sapiens_hsa043500.72479339
51Thyroid cancer_Homo sapiens_hsa052160.71255608
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66823530
53Pentose phosphate pathway_Homo sapiens_hsa000300.65749050
54Selenocompound metabolism_Homo sapiens_hsa004500.65446093
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65144850
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.61121359
57Folate biosynthesis_Homo sapiens_hsa007900.57069298
58Oxidative phosphorylation_Homo sapiens_hsa001900.56859118
59Adherens junction_Homo sapiens_hsa045200.55492071
60Hedgehog signaling pathway_Homo sapiens_hsa043400.54586163
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.54032016
62Colorectal cancer_Homo sapiens_hsa052100.52916852
63Alcoholism_Homo sapiens_hsa050340.51212358
64Bladder cancer_Homo sapiens_hsa052190.50554185
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49757921
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48980986
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46705912
68Legionellosis_Homo sapiens_hsa051340.45411339
69Glutathione metabolism_Homo sapiens_hsa004800.45252834
70Apoptosis_Homo sapiens_hsa042100.44575846
71Notch signaling pathway_Homo sapiens_hsa043300.43546160
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41636434
73Carbon metabolism_Homo sapiens_hsa012000.36836973
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35949060
75Pathways in cancer_Homo sapiens_hsa052000.35935430
76Metabolic pathways_Homo sapiens_hsa011000.35845755
77Chronic myeloid leukemia_Homo sapiens_hsa052200.35540389
78Tight junction_Homo sapiens_hsa045300.34193157
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33785184
80Hepatitis B_Homo sapiens_hsa051610.33443786
81Prostate cancer_Homo sapiens_hsa052150.31383132
82Alzheimers disease_Homo sapiens_hsa050100.30767922
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30685819
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29983649
85HIF-1 signaling pathway_Homo sapiens_hsa040660.29422850
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29053789
87mTOR signaling pathway_Homo sapiens_hsa041500.28900617
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.28721803
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28437618
90Viral myocarditis_Homo sapiens_hsa054160.28169196
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27791394
92Fructose and mannose metabolism_Homo sapiens_hsa000510.27411932
93Shigellosis_Homo sapiens_hsa051310.26928834
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25792149
95Arginine and proline metabolism_Homo sapiens_hsa003300.23850127
96Wnt signaling pathway_Homo sapiens_hsa043100.23752137
97Melanoma_Homo sapiens_hsa052180.22954441
98Fatty acid metabolism_Homo sapiens_hsa012120.22755598
99Lysine degradation_Homo sapiens_hsa003100.22362185
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21984118
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21953790
102Influenza A_Homo sapiens_hsa051640.21415581
103Proteoglycans in cancer_Homo sapiens_hsa052050.20707454
104FoxO signaling pathway_Homo sapiens_hsa040680.19393853
105Pancreatic cancer_Homo sapiens_hsa052120.19099965
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18544215
107Huntingtons disease_Homo sapiens_hsa050160.17884197
108Measles_Homo sapiens_hsa051620.15913343
109Sulfur relay system_Homo sapiens_hsa041220.14959925
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14107949
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14101185
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.14077826
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13702235
114Endometrial cancer_Homo sapiens_hsa052130.13410808
115Non-small cell lung cancer_Homo sapiens_hsa052230.12181250
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11506512
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10683139
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08912090
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.07946918
120Protein export_Homo sapiens_hsa030600.07055473
121Renin-angiotensin system_Homo sapiens_hsa046140.06080677
122Galactose metabolism_Homo sapiens_hsa000520.05406110
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03938073

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