MEIS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* definitive hemopoiesis (GO:0060216)9.18821368
2ribosomal small subunit assembly (GO:0000028)6.92364442
3platelet dense granule organization (GO:0060155)5.42357010
4* megakaryocyte development (GO:0035855)5.25518982
5antigen processing and presentation via MHC class Ib (GO:0002475)5.09183613
6behavioral response to nicotine (GO:0035095)4.80429141
7fucose catabolic process (GO:0019317)4.78137533
8L-fucose metabolic process (GO:0042354)4.78137533
9L-fucose catabolic process (GO:0042355)4.78137533
10lymphoid progenitor cell differentiation (GO:0002320)4.71474493
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68419592
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68419592
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60544810
14endosome to pigment granule transport (GO:0043485)4.58144176
15endosome to melanosome transport (GO:0035646)4.58144176
16negative regulation of erythrocyte differentiation (GO:0045647)4.33328081
17thrombin receptor signaling pathway (GO:0070493)4.23136490
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.92940191
19aggressive behavior (GO:0002118)3.89351049
20viral transcription (GO:0019083)3.86105851
21doxorubicin metabolic process (GO:0044598)3.85642929
22daunorubicin metabolic process (GO:0044597)3.85642929
23polyketide metabolic process (GO:0030638)3.85642929
24translational termination (GO:0006415)3.76959727
25embryonic hemopoiesis (GO:0035162)3.76081877
26antigen processing and presentation of endogenous antigen (GO:0019883)3.70314182
27heparin biosynthetic process (GO:0030210)3.66171888
28heparin metabolic process (GO:0030202)3.66171888
29secretory granule organization (GO:0033363)3.65194342
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43792415
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38628408
32negative regulation of phagocytosis (GO:0050765)3.37752101
33cotranslational protein targeting to membrane (GO:0006613)3.33985567
34positive regulation of granulocyte differentiation (GO:0030854)3.33888990
35protein targeting to ER (GO:0045047)3.31445210
36positive regulation of B cell differentiation (GO:0045579)3.28801645
37poly(A)+ mRNA export from nucleus (GO:0016973)3.27592002
38response to interferon-beta (GO:0035456)3.26656611
39phospholipid scrambling (GO:0017121)3.25214310
40positive regulation of respiratory burst (GO:0060267)3.24736330
41translational elongation (GO:0006414)3.22484755
42pancreas development (GO:0031016)3.20739536
43necroptotic process (GO:0070266)3.20295898
44lymph node development (GO:0048535)3.19636362
45ribosomal small subunit biogenesis (GO:0042274)3.19191083
46organ formation (GO:0048645)3.18325051
47IMP biosynthetic process (GO:0006188)3.17145279
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16915738
49telomere maintenance via semi-conservative replication (GO:0032201)3.16910738
50response to pheromone (GO:0019236)3.16132944
51activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.15332173
52protein localization to cilium (GO:0061512)3.13739253
53protein localization to endoplasmic reticulum (GO:0070972)3.13546653
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11832111
55tRNA methylation (GO:0030488)3.09295745
56regulation of glucokinase activity (GO:0033131)3.07447232
57regulation of hexokinase activity (GO:1903299)3.07447232
58IMP metabolic process (GO:0046040)3.06192020
59regulation of secondary heart field cardioblast proliferation (GO:0003266)3.02793295
60regulation of cardioblast proliferation (GO:0003264)3.02793295
61axoneme assembly (GO:0035082)3.02354463
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01440048
63response to interferon-alpha (GO:0035455)2.97692458
64intraciliary transport (GO:0042073)2.96797805
65DNA deamination (GO:0045006)2.94387684
66mature B cell differentiation involved in immune response (GO:0002313)2.92222157
67regulation of erythrocyte differentiation (GO:0045646)2.91962862
68viral mRNA export from host cell nucleus (GO:0046784)2.91478678
69nitric oxide mediated signal transduction (GO:0007263)2.89557978
70DNA topological change (GO:0006265)2.86835925
71mast cell activation (GO:0045576)2.86086517
72DNA strand elongation (GO:0022616)2.84858651
73mast cell degranulation (GO:0043303)2.84764723
74mast cell activation involved in immune response (GO:0002279)2.84764723
75maturation of SSU-rRNA (GO:0030490)2.84586868
76dendritic spine morphogenesis (GO:0060997)2.82533071
77respiratory chain complex IV assembly (GO:0008535)2.81957070
78negative regulation of heart rate (GO:0010459)2.81695108
79viral life cycle (GO:0019058)2.79862400
803-UTR-mediated mRNA stabilization (GO:0070935)2.79459663
81T cell homeostasis (GO:0043029)2.79410166
82fucosylation (GO:0036065)2.78414877
83DNA ligation (GO:0006266)2.78011281
84hematopoietic stem cell differentiation (GO:0060218)2.75573148
85kidney morphogenesis (GO:0060993)2.73475228
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.71783313
87negative regulation of transcription by competitive promoter binding (GO:0010944)2.70498324
88telomere maintenance via recombination (GO:0000722)2.70347548
89negative regulation of neurological system process (GO:0031645)2.70013359
90cell differentiation involved in metanephros development (GO:0072202)2.68950754
91positive regulation of glomerulus development (GO:0090193)2.68832218
92DNA strand elongation involved in DNA replication (GO:0006271)2.68682378
93protein polyglutamylation (GO:0018095)2.67335911
94cellular response to thyroid hormone stimulus (GO:0097067)2.66671042
95synaptic transmission, cholinergic (GO:0007271)2.65018520
96cellular protein complex disassembly (GO:0043624)2.63601591
97positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.63247117
98mRNA catabolic process (GO:0006402)2.62937440
99parental behavior (GO:0060746)2.61169540
100protein ADP-ribosylation (GO:0006471)2.60822224
101retinal ganglion cell axon guidance (GO:0031290)2.60410605
102inositol phosphate catabolic process (GO:0071545)2.60337211
103prenylation (GO:0097354)2.59491008
104protein prenylation (GO:0018342)2.59491008
105somite development (GO:0061053)2.59336268
106photoreceptor cell maintenance (GO:0045494)2.59250631
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58101333
108mannosylation (GO:0097502)2.57281632
109limb development (GO:0060173)2.56049387
110appendage development (GO:0048736)2.56049387
111regulation of necroptotic process (GO:0060544)2.55344170
112positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55293880
113regulation of cilium movement (GO:0003352)2.55068641
114presynaptic membrane assembly (GO:0097105)2.53844909
115cilium organization (GO:0044782)2.53735403
116atrial cardiac muscle cell action potential (GO:0086014)2.53617699
117dentate gyrus development (GO:0021542)2.53352079
118myeloid dendritic cell activation (GO:0001773)2.52846678
119protein complex disassembly (GO:0043241)2.52534797
120positive regulation of mitochondrial fission (GO:0090141)2.52401462
121regulation of action potential (GO:0098900)2.52354937
122regulation of developmental pigmentation (GO:0048070)2.52183539
123pyrimidine nucleobase catabolic process (GO:0006208)2.52158057
124positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.51926412
125negative regulation of RNA splicing (GO:0033119)2.51508327
126negative regulation of viral genome replication (GO:0045071)2.50264234
127cellular ketone body metabolic process (GO:0046950)2.50169766
128male genitalia development (GO:0030539)2.49909111
129regulation of glomerulus development (GO:0090192)2.49842750
130blood vessel maturation (GO:0001955)2.49343578
131RNA catabolic process (GO:0006401)2.48564556
132cilium morphogenesis (GO:0060271)2.48517910
133cilium assembly (GO:0042384)2.47848773
134negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.47232344
135response to protozoan (GO:0001562)2.47112722
136endothelium development (GO:0003158)2.46644615
137* myeloid cell development (GO:0061515)2.46507229
138epithelial cilium movement (GO:0003351)2.46434565
139retinal cone cell development (GO:0046549)2.45767268
140negative regulation of mast cell activation (GO:0033004)2.45723418
141sulfation (GO:0051923)2.45583700
142positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.44106631
143regulation of type B pancreatic cell apoptotic process (GO:2000674)2.43746040
144lateral sprouting from an epithelium (GO:0060601)2.43534051
145indolalkylamine metabolic process (GO:0006586)2.42892617
146neuronal action potential (GO:0019228)2.42699536
147prostate gland growth (GO:0060736)2.41923987
148behavioral response to ethanol (GO:0048149)2.41905558
149preassembly of GPI anchor in ER membrane (GO:0016254)2.41649517
150histamine transport (GO:0051608)2.41227821
151alternative mRNA splicing, via spliceosome (GO:0000380)2.40853629
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40316537
153nucleosome disassembly (GO:0006337)2.40181573
154protein-DNA complex disassembly (GO:0032986)2.40181573
155cytokine production involved in immune response (GO:0002367)2.40114714
156fucose metabolic process (GO:0006004)2.39927361
157regulation of stem cell maintenance (GO:2000036)2.39809156
158neuromuscular synaptic transmission (GO:0007274)2.39615860
159water-soluble vitamin biosynthetic process (GO:0042364)2.39251908
160embryonic camera-type eye morphogenesis (GO:0048596)2.39128269
161mitotic recombination (GO:0006312)2.38994578
162cyclooxygenase pathway (GO:0019371)2.38962015
163DNA unwinding involved in DNA replication (GO:0006268)2.38940878
164negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.38270436
165parturition (GO:0007567)2.37618515
166regulation of female receptivity (GO:0045924)2.37004171
167xenobiotic catabolic process (GO:0042178)2.36361912
168nonmotile primary cilium assembly (GO:0035058)2.36023274
169negative regulation of dendrite development (GO:2000171)2.34827551
170positive regulation of cardiac muscle cell differentiation (GO:2000727)2.34348864
171protein neddylation (GO:0045116)2.33385955
172negative regulation of cation channel activity (GO:2001258)2.32602671
173nucleobase catabolic process (GO:0046113)2.31603773
174presynaptic membrane organization (GO:0097090)2.31574180
175piRNA metabolic process (GO:0034587)2.31541813
176regulation of penile erection (GO:0060405)2.31064806
177tryptophan catabolic process (GO:0006569)2.30700447
178indole-containing compound catabolic process (GO:0042436)2.30700447
179indolalkylamine catabolic process (GO:0046218)2.30700447
180seminiferous tubule development (GO:0072520)2.29932054
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.29414726
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.29414726
183maternal behavior (GO:0042711)2.29175365
184regulation of respiratory system process (GO:0044065)2.28220531
185sympathetic nervous system development (GO:0048485)2.26963492
186benzene-containing compound metabolic process (GO:0042537)2.26310218
187ketone body metabolic process (GO:1902224)2.25777332
188detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.25766524
189neuron fate determination (GO:0048664)2.25297920
190relaxation of smooth muscle (GO:0044557)2.24436570
191brain morphogenesis (GO:0048854)2.24325716
192regulation of vasculogenesis (GO:2001212)2.23415358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.86751083
2SCL_19346495_ChIP-Seq_HPC-7_Human5.79020800
3GBX2_23144817_ChIP-Seq_PC3_Human3.76679602
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60646415
5GATA1_22025678_ChIP-Seq_K562_Human3.37712714
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29366242
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21193667
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.12828585
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.05844778
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.03046316
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.97766522
12TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.87785025
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87233913
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79243967
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74278828
16* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72917280
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.72506652
18* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72237674
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.71122147
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.69358614
21* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67143688
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56333878
23IGF1R_20145208_ChIP-Seq_DFB_Human2.53129111
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.51747494
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50820088
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50231561
27* TP63_19390658_ChIP-ChIP_HaCaT_Human2.49146177
28* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.48796743
29ERG_20887958_ChIP-Seq_HPC-7_Mouse2.43579186
30TAF15_26573619_Chip-Seq_HEK293_Human2.37108619
31ZNF274_21170338_ChIP-Seq_K562_Hela2.34469705
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.34336834
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29911568
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26826394
35VDR_22108803_ChIP-Seq_LS180_Human2.23895114
36* P300_19829295_ChIP-Seq_ESCs_Human2.21626050
37* FUS_26573619_Chip-Seq_HEK293_Human2.20723851
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18792769
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17134460
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16860363
41SPI1_23547873_ChIP-Seq_NB4_Human2.15660011
42EZH2_22144423_ChIP-Seq_EOC_Human2.15373357
43RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11147715
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10144018
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.09371389
46MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07566849
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03763689
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.02697538
49CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02455293
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00379014
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99836893
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99631720
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96610615
54GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.95758613
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94304419
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.94143018
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94015041
58CIITA_25753668_ChIP-Seq_RAJI_Human1.93774217
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.92046465
60VDR_21846776_ChIP-Seq_THP-1_Human1.87531363
61FOXP3_21729870_ChIP-Seq_TREG_Human1.84334972
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.82645784
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81345046
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.81021376
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77932137
66* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72965258
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72771487
68* PIAS1_25552417_ChIP-Seq_VCAP_Human1.71693378
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70886533
70MYC_22102868_ChIP-Seq_BL_Human1.68231535
71VDR_23849224_ChIP-Seq_CD4+_Human1.67470828
72ER_23166858_ChIP-Seq_MCF-7_Human1.65454658
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.65121782
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.64667442
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64185158
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.64013107
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63190327
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62577932
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62085651
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61391793
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61142699
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61068919
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59471610
84STAT3_23295773_ChIP-Seq_U87_Human1.59290646
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.58698951
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.57915209
87RUNX_20019798_ChIP-Seq_JUKART_Human1.57172362
88* CBX2_27304074_Chip-Seq_ESCs_Mouse1.54722819
89* ELK1_19687146_ChIP-ChIP_HELA_Human1.54150134
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53764626
91* AR_25329375_ChIP-Seq_VCAP_Human1.53218581
92RNF2_27304074_Chip-Seq_NSC_Mouse1.52955418
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52698788
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52545236
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.51272869
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50828115
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49453514
98VDR_24763502_ChIP-Seq_THP-1_Human1.49446965
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48626923
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.48471699
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48045759
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47652156
103IRF1_19129219_ChIP-ChIP_H3396_Human1.45965048
104* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43153066
105* TCF4_23295773_ChIP-Seq_U87_Human1.42861151
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.42801772
107XRN2_22483619_ChIP-Seq_HELA_Human1.42475584
108* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39699934
109* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39584605
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39364468
111BCAT_22108803_ChIP-Seq_LS180_Human1.38646060
112* EED_16625203_ChIP-ChIP_MESCs_Mouse1.38507505
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38405720
114IRF8_21731497_ChIP-ChIP_J774_Mouse1.38291497
115TCF7_22412390_ChIP-Seq_EML_Mouse1.38233810
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37724133
117CBP_20019798_ChIP-Seq_JUKART_Human1.37724133
118* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37704976
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37188777
120MYB_26560356_Chip-Seq_TH1_Human1.36507239
121* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34580040
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34112982
123* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33357126
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33082470
125JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31127359
126P53_22387025_ChIP-Seq_ESCs_Mouse1.30697024
127* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29712780
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29455858
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28292349
130* FLI1_21867929_ChIP-Seq_TH2_Mouse1.27737383
131MYB_26560356_Chip-Seq_TH2_Human1.27348801
132ETS1_20019798_ChIP-Seq_JURKAT_Human1.27217561
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26838401
134NANOG_19829295_ChIP-Seq_ESCs_Human1.25693795
135SOX2_19829295_ChIP-Seq_ESCs_Human1.25693795
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25547307
137* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23087476
138* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22784015
139* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22784015
140* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22285840
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21836567
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21560280
143PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21509230
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21445941
145* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21296784
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.19921041
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18305771
148MAF_26560356_Chip-Seq_TH1_Human1.18131541
149NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17674398
150E2F1_18555785_Chip-Seq_ESCs_Mouse1.16831882
151RUNX2_22187159_ChIP-Seq_PCA_Human1.16374688
152THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16340708
153ETS1_22383799_ChIP-Seq_G1ME_Mouse1.15995251
154* TCF4_22108803_ChIP-Seq_LS180_Human1.15821647
155* TAL1_26923725_Chip-Seq_HPCs_Mouse1.15250862
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14048170
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14048170
158* CRX_20693478_ChIP-Seq_RETINA_Mouse1.13693717
159* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13357455
160CMYC_18555785_Chip-Seq_ESCs_Mouse1.12967707
161* EZH2_27304074_Chip-Seq_ESCs_Mouse1.12842284
162TTF2_22483619_ChIP-Seq_HELA_Human1.12050089
163* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11868385
164NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10826856
165* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10688701
166SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10637678
167E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10570462
168RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10148651
169* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09345862
170SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09250405
171* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08688619
172MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08373545
173SOX2_21211035_ChIP-Seq_LN229_Gbm1.07457037
174RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07391781
175EP300_21415370_ChIP-Seq_HL-1_Mouse1.07326417
176KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07161305
177ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07033840
178CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06474910
179KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05601399
180* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05045492
181* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04360651
182* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03873805
183CDX2_22108803_ChIP-Seq_LS180_Human1.03552546
184UTX_26944678_Chip-Seq_JUKART_Human1.01993251
185GABP_19822575_ChIP-Seq_HepG2_Human1.01079434
186STAT3_18555785_Chip-Seq_ESCs_Mouse1.00888605
187TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99369081
188CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95366727
189* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95357803
190* MYC_18940864_ChIP-ChIP_HL60_Human0.92818976
191FOXM1_23109430_ChIP-Seq_U2OS_Human0.92346610
192GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89766036
193EWS_26573619_Chip-Seq_HEK293_Human0.89764562
194ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88767632
195STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86338334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.64745284
2MP0004147_increased_porphyrin_level4.53410000
3MP0005174_abnormal_tail_pigmentation3.80662515
4MP0004808_abnormal_hematopoietic_stem3.71844013
5MP0002102_abnormal_ear_morphology3.66404990
6MP0002638_abnormal_pupillary_reflex3.08667042
7MP0010386_abnormal_urinary_bladder3.04501843
8MP0005075_abnormal_melanosome_morpholog3.04151282
9MP0003195_calcinosis2.83841464
10MP0002095_abnormal_skin_pigmentation2.81663442
11MP0001188_hyperpigmentation2.64377521
12MP0002938_white_spotting2.63943331
13MP0003943_abnormal_hepatobiliary_system2.52523741
14MP0006054_spinal_hemorrhage2.46238661
15MP0000465_gastrointestinal_hemorrhage2.42040803
16MP0005397_hematopoietic_system_phenotyp2.33304450
17MP0001545_abnormal_hematopoietic_system2.33304450
18MP0006072_abnormal_retinal_apoptosis2.27636890
19MP0006292_abnormal_olfactory_placode2.23177671
20MP0000015_abnormal_ear_pigmentation2.21546936
21MP0005464_abnormal_platelet_physiology2.21124248
22MP0008877_abnormal_DNA_methylation2.13897151
23MP0001835_abnormal_antigen_presentation2.11293598
24MP0008775_abnormal_heart_ventricle2.07269428
25MP0008007_abnormal_cellular_replicative2.02046327
26MP0005253_abnormal_eye_physiology1.96379365
27MP0003567_abnormal_fetal_cardiomyocyte1.94780660
28MP0002837_dystrophic_cardiac_calcinosis1.94386166
29MP0005187_abnormal_penis_morphology1.92001366
30MP0006276_abnormal_autonomic_nervous1.88309846
31MP0005551_abnormal_eye_electrophysiolog1.84593278
32MP0005409_darkened_coat_color1.82541054
33MP0010094_abnormal_chromosome_stability1.80832597
34MP0009278_abnormal_bone_marrow1.76732661
35MP0002736_abnormal_nociception_after1.76161991
36MP0001968_abnormal_touch/_nociception1.72300718
37MP0001986_abnormal_taste_sensitivity1.68652708
38MP0002877_abnormal_melanocyte_morpholog1.68552649
39MP0005671_abnormal_response_to1.67981650
40MP0000490_abnormal_crypts_of1.66232336
41MP0010368_abnormal_lymphatic_system1.65931259
42* MP0002398_abnormal_bone_marrow1.65110914
43MP0003763_abnormal_thymus_physiology1.64585576
44MP0000013_abnormal_adipose_tissue1.63777804
45MP0009379_abnormal_foot_pigmentation1.63759183
46MP0000631_abnormal_neuroendocrine_gland1.61381584
47MP0004215_abnormal_myocardial_fiber1.59939437
48MP0008058_abnormal_DNA_repair1.59315421
49MP0000383_abnormal_hair_follicle1.57633074
50MP0001984_abnormal_olfaction1.51234628
51MP0009785_altered_susceptibility_to1.51039914
52MP0002822_catalepsy1.49968971
53MP0003121_genomic_imprinting1.49360897
54MP0002160_abnormal_reproductive_system1.48174667
55MP0004142_abnormal_muscle_tone1.47440675
56MP0009780_abnormal_chondrocyte_physiolo1.46394382
57MP0000689_abnormal_spleen_morphology1.40692960
58MP0002249_abnormal_larynx_morphology1.38300015
59MP0002722_abnormal_immune_system1.37911146
60MP0005645_abnormal_hypothalamus_physiol1.37062126
61MP0000685_abnormal_immune_system1.35887063
62MP0000681_abnormal_thyroid_gland1.35754130
63MP0003283_abnormal_digestive_organ1.33865688
64MP0004885_abnormal_endolymph1.33784636
65MP0009046_muscle_twitch1.33668542
66MP0002132_abnormal_respiratory_system1.31972345
67MP0000230_abnormal_systemic_arterial1.31708066
68MP0001486_abnormal_startle_reflex1.31170623
69MP0002272_abnormal_nervous_system1.30239908
70* MP0002429_abnormal_blood_cell1.28970899
71MP0000566_synostosis1.28000279
72MP0002735_abnormal_chemical_nociception1.27674910
73MP0001879_abnormal_lymphatic_vessel1.26021569
74MP0002751_abnormal_autonomic_nervous1.23794560
75MP0000716_abnormal_immune_system1.21451157
76MP0009697_abnormal_copulation1.20935833
77MP0001293_anophthalmia1.20906369
78MP0005025_abnormal_response_to1.20626774
79MP0000703_abnormal_thymus_morphology1.20272358
80MP0000678_abnormal_parathyroid_gland1.20250141
81MP0002420_abnormal_adaptive_immunity1.18176651
82MP0008057_abnormal_DNA_replication1.16955000
83MP0003787_abnormal_imprinting1.16252051
84MP0003077_abnormal_cell_cycle1.16199481
85MP0000538_abnormal_urinary_bladder1.15635472
86MP0001819_abnormal_immune_cell1.14928949
87MP0000372_irregular_coat_pigmentation1.14831871
88MP0002184_abnormal_innervation1.14195037
89MP0000427_abnormal_hair_cycle1.13881983
90MP0002557_abnormal_social/conspecific_i1.13457236
91MP0000516_abnormal_urinary_system1.12997154
92MP0005367_renal/urinary_system_phenotyp1.12997154
93MP0003693_abnormal_embryo_hatching1.12404959
94MP0003119_abnormal_digestive_system1.12171121
95MP0001970_abnormal_pain_threshold1.12160817
96MP0003279_aneurysm1.11384087
97MP0003880_abnormal_central_pattern1.11190237
98MP0003937_abnormal_limbs/digits/tail_de1.10628316
99MP0004264_abnormal_extraembryonic_tissu1.10600749
100MP0002452_abnormal_antigen_presenting1.09876600
101MP0004085_abnormal_heartbeat1.08201037
102MP0005389_reproductive_system_phenotype1.08089349
103MP0003123_paternal_imprinting1.06206933
104MP0010155_abnormal_intestine_physiology1.05569709
105MP0002733_abnormal_thermal_nociception1.05402982
106MP0001270_distended_abdomen1.05348677
107MP0000639_abnormal_adrenal_gland1.05273257
108MP0002075_abnormal_coat/hair_pigmentati1.05056753
109MP0010678_abnormal_skin_adnexa1.04973729
110MP0009745_abnormal_behavioral_response1.04796330
111MP0002127_abnormal_cardiovascular_syste1.04336543
112MP0002282_abnormal_trachea_morphology1.03124716
113MP0001800_abnormal_humoral_immune1.02359739
114MP0002572_abnormal_emotion/affect_behav1.01618763
115MP0002928_abnormal_bile_duct1.00911128
116MP0003724_increased_susceptibility_to1.00467375
117MP0002723_abnormal_immune_serum1.00196345
118MP0003942_abnormal_urinary_system0.99701410
119MP0005084_abnormal_gallbladder_morpholo0.99111262
120MP0002177_abnormal_outer_ear0.98422275
121MP0001756_abnormal_urination0.95954535
122MP0005386_behavior/neurological_phenoty0.93680037
123MP0004924_abnormal_behavior0.93680037
124MP0001853_heart_inflammation0.91675298
125MP0008004_abnormal_stomach_pH0.90346877
126MP0005503_abnormal_tendon_morphology0.88141689
127MP0001529_abnormal_vocalization0.87880985
128MP0008872_abnormal_physiological_respon0.87813915
129MP0004145_abnormal_muscle_electrophysio0.86554793
130MP0000537_abnormal_urethra_morphology0.86549565
131MP0005083_abnormal_biliary_tract0.86454704
132MP0002734_abnormal_mechanical_nocicepti0.85577203
133MP0004084_abnormal_cardiac_muscle0.84902113
134MP0002876_abnormal_thyroid_physiology0.84786683
135MP0002419_abnormal_innate_immunity0.83787525
136MP0005410_abnormal_fertilization0.83700714
137MP0004133_heterotaxia0.83415460
138MP0002166_altered_tumor_susceptibility0.81545587
139MP0000313_abnormal_cell_death0.81257267
140MP0002064_seizures0.80929247
141* MP0005195_abnormal_posterior_eye0.80754152
142MP0001905_abnormal_dopamine_level0.80487190
143MP0002148_abnormal_hypersensitivity_rea0.79855807
144MP0004782_abnormal_surfactant_physiolog0.79137542
145MP0002752_abnormal_somatic_nervous0.79126662
146MP0001119_abnormal_female_reproductive0.79021565
147MP0002089_abnormal_postnatal_growth/wei0.78693886
148MP0005171_absent_coat_pigmentation0.78443411
149MP0003122_maternal_imprinting0.78416350
150MP0005391_vision/eye_phenotype0.78321909
151MP0001664_abnormal_digestion0.78281300
152MP0000778_abnormal_nervous_system0.77857859
153MP0001764_abnormal_homeostasis0.77677388
154MP0003111_abnormal_nucleus_morphology0.77154607
155MP0000343_altered_response_to0.76689687
156MP0003011_delayed_dark_adaptation0.76470622
157MP0000647_abnormal_sebaceous_gland0.75261348
158MP0009333_abnormal_splenocyte_physiolog0.75119512
159MP0002234_abnormal_pharynx_morphology0.74133525
160MP0002019_abnormal_tumor_incidence0.73716490
161MP0004484_altered_response_of0.73592962
162MP0000049_abnormal_middle_ear0.72814060
163MP0003866_abnormal_defecation0.72438399
164MP0000569_abnormal_digit_pigmentation0.72269412
165MP0009053_abnormal_anal_canal0.71464224
166MP0003828_pulmonary_edema0.70709374
167MP0010630_abnormal_cardiac_muscle0.70584944
168MP0003941_abnormal_skin_development0.70261513
169MP0005646_abnormal_pituitary_gland0.70034126
170MP0001915_intracranial_hemorrhage0.69353205
171MP0001873_stomach_inflammation0.68578109
172MP0005000_abnormal_immune_tolerance0.67099544
173MP0005220_abnormal_exocrine_pancreas0.66678975
174MP0000767_abnormal_smooth_muscle0.63520035
175MP0000534_abnormal_ureter_morphology0.60433998
176MP0009250_abnormal_appendicular_skeleto0.60387184

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.95463905
2Prolonged bleeding time (HP:0003010)4.66047944
3Thrombocytosis (HP:0001894)4.59597332
4Chronic otitis media (HP:0000389)4.25075468
5Acute myeloid leukemia (HP:0004808)4.04499489
6Petechiae (HP:0000967)4.01821694
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.79534409
8Pancreatic cysts (HP:0001737)3.76563791
9White forelock (HP:0002211)3.65990241
10Patchy hypopigmentation of hair (HP:0011365)3.64969950
11Type I transferrin isoform profile (HP:0003642)3.59422842
12Pancreatic fibrosis (HP:0100732)3.54848730
13Medial flaring of the eyebrow (HP:0010747)3.44500070
14Increased corneal curvature (HP:0100692)3.42185159
15Keratoconus (HP:0000563)3.42185159
16Nephronophthisis (HP:0000090)3.39578759
17True hermaphroditism (HP:0010459)3.39241683
18Abnormal number of erythroid precursors (HP:0012131)3.32701878
19Epistaxis (HP:0000421)3.24393599
20Myositis (HP:0100614)3.21591406
21Abnormality of cells of the erythroid lineage (HP:0012130)3.17785549
22Syringomyelia (HP:0003396)3.12736909
23Spinal cord lesions (HP:0100561)3.12736909
24Elevated erythrocyte sedimentation rate (HP:0003565)3.10915918
25Abnormality of the renal medulla (HP:0100957)3.04220661
26IgM deficiency (HP:0002850)2.95397700
27Reticulocytopenia (HP:0001896)2.94182790
28Abnormality of the renal cortex (HP:0011035)2.92884745
29Morphological abnormality of the middle ear (HP:0008609)2.89346213
30Reduced antithrombin III activity (HP:0001976)2.87158121
31Gait imbalance (HP:0002141)2.84797663
32Congenital primary aphakia (HP:0007707)2.83656360
33Myelodysplasia (HP:0002863)2.82021808
34Long clavicles (HP:0000890)2.81507011
35Methylmalonic acidemia (HP:0002912)2.80496402
36Abnormal protein glycosylation (HP:0012346)2.79200321
37Abnormal glycosylation (HP:0012345)2.79200321
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79200321
39Abnormal protein N-linked glycosylation (HP:0012347)2.79200321
40Acute lymphatic leukemia (HP:0006721)2.75843652
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.75295827
42Short 1st metacarpal (HP:0010034)2.75295827
43Renal cortical cysts (HP:0000803)2.74190925
44Abnormality of midbrain morphology (HP:0002418)2.74100463
45Molar tooth sign on MRI (HP:0002419)2.74100463
46Menorrhagia (HP:0000132)2.72934119
47Volvulus (HP:0002580)2.71427152
48Genital tract atresia (HP:0001827)2.70945367
49Attenuation of retinal blood vessels (HP:0007843)2.70481509
50Hypoglycemic coma (HP:0001325)2.70382232
51Hemiparesis (HP:0001269)2.67106904
52Nephrogenic diabetes insipidus (HP:0009806)2.66424611
53Vaginal atresia (HP:0000148)2.66168661
54Gingival bleeding (HP:0000225)2.65773276
55Abolished electroretinogram (ERG) (HP:0000550)2.63751904
56Type 2 muscle fiber atrophy (HP:0003554)2.60389925
57Abnormality of the parietal bone (HP:0002696)2.60308217
58Intestinal atresia (HP:0011100)2.59294731
59Weak cry (HP:0001612)2.52647906
60Cutaneous melanoma (HP:0012056)2.52597024
61Chronic hepatic failure (HP:0100626)2.47655383
62Muscle fiber atrophy (HP:0100295)2.43493285
63Hypothermia (HP:0002045)2.41595479
64Decreased central vision (HP:0007663)2.40668101
65Tubulointerstitial nephritis (HP:0001970)2.39969199
66Abnormality of the fingertips (HP:0001211)2.37464158
67Congenital stationary night blindness (HP:0007642)2.36752012
68Asymmetry of the thorax (HP:0001555)2.36064987
69Hypoproteinemia (HP:0003075)2.35098645
7011 pairs of ribs (HP:0000878)2.34685239
71Pancytopenia (HP:0001876)2.34607738
72Abnormality of the 1st metacarpal (HP:0010009)2.34042263
73Febrile seizures (HP:0002373)2.33817137
74Hypoglycemic seizures (HP:0002173)2.33450181
75Abnormal platelet function (HP:0011869)2.31261962
76Impaired platelet aggregation (HP:0003540)2.31261962
77Germ cell neoplasia (HP:0100728)2.29833104
78Gaze-evoked nystagmus (HP:0000640)2.27874669
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.27530422
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.26661574
81Congenital sensorineural hearing impairment (HP:0008527)2.25879566
82Eczematoid dermatitis (HP:0000976)2.25843489
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25695161
84Cystic liver disease (HP:0006706)2.23029283
85Tubulointerstitial abnormality (HP:0001969)2.21181628
86Polydipsia (HP:0001959)2.19539464
87Abnormal drinking behavior (HP:0030082)2.19539464
88Neonatal hypoglycemia (HP:0001998)2.18282652
89Chorioretinal atrophy (HP:0000533)2.17628216
90Purpura (HP:0000979)2.17288578
91Bruising susceptibility (HP:0000978)2.17075028
92Short 4th metacarpal (HP:0010044)2.16268029
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16268029
94Orchitis (HP:0100796)2.11349428
95Hyperventilation (HP:0002883)2.10757380
96Abnormality of the phalanges of the 5th finger (HP:0004213)2.10319763
97Optic neuritis (HP:0100653)2.10133162
98Retrobulbar optic neuritis (HP:0100654)2.10133162
99Clubbing of toes (HP:0100760)2.09552569
100Abnormality of the proximal phalanges of the hand (HP:0009834)2.08508907
101Abnormality of the columella (HP:0009929)2.08214731
102Abnormal hair whorl (HP:0010721)2.07515495
103Congenital hepatic fibrosis (HP:0002612)2.07019868
104Optic nerve coloboma (HP:0000588)2.06882005
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.06506796
106Large for gestational age (HP:0001520)2.06335074
107Pallor (HP:0000980)2.06198366
108Poor coordination (HP:0002370)2.05694448
109Postaxial hand polydactyly (HP:0001162)2.05172952
110Amaurosis fugax (HP:0100576)2.04811198
111Heterochromia iridis (HP:0001100)2.04377390
112Type II lissencephaly (HP:0007260)2.03512414
113Tubular atrophy (HP:0000092)2.01559304
114Panhypogammaglobulinemia (HP:0003139)2.01338669
115Microcytic anemia (HP:0001935)2.01126697
116Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00803234
117Arterial thrombosis (HP:0004420)2.00213663
118Optic nerve hypoplasia (HP:0000609)2.00211482
119Recurrent bronchitis (HP:0002837)1.99513515
120Severe visual impairment (HP:0001141)1.99344705
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.98577840
122Hyperinsulinemic hypoglycemia (HP:0000825)1.98428155
123Asplenia (HP:0001746)1.98296519
124Agitation (HP:0000713)1.98185769
125Abnormality of macular pigmentation (HP:0008002)1.98145996
126Abnormality of the prostate (HP:0008775)1.97991150
127Spontaneous hematomas (HP:0007420)1.97723229
128Nemaline bodies (HP:0003798)1.97512941
129Abnormality of T cell physiology (HP:0011840)1.97246830
130Postaxial foot polydactyly (HP:0001830)1.96995512
131Ketoacidosis (HP:0001993)1.95680605
132Osteomyelitis (HP:0002754)1.95586958
133Bile duct proliferation (HP:0001408)1.93761162
134Abnormal biliary tract physiology (HP:0012439)1.93761162
135Encephalitis (HP:0002383)1.93738720
136Cutaneous finger syndactyly (HP:0010554)1.93148567
137Short tibia (HP:0005736)1.93132550
138Abnormal platelet volume (HP:0011876)1.91990872
139Portal hypertension (HP:0001409)1.91964679
140Abnormality of B cell number (HP:0010975)1.90919889
141B lymphocytopenia (HP:0010976)1.90919889
142Diastasis recti (HP:0001540)1.90323513
143Hematochezia (HP:0002573)1.88798176
144Furrowed tongue (HP:0000221)1.88051410
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87497457
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.87306375
147Decreased skull ossification (HP:0004331)1.87086076
148Anencephaly (HP:0002323)1.86587748
149Agammaglobulinemia (HP:0004432)1.86323517
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.86168958
151Abnormal rod and cone electroretinograms (HP:0008323)1.85583488
152Cellulitis (HP:0100658)1.85159683
153Absent/shortened dynein arms (HP:0200106)1.84542707
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.84542707
155Short hallux (HP:0010109)1.84508950
156Disproportionate short-trunk short stature (HP:0003521)1.84508633
157Decreased circulating renin level (HP:0003351)1.84399146
158Male pseudohermaphroditism (HP:0000037)1.83516511
159Osteolytic defects of the hand bones (HP:0009699)1.82942467
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.82942467
161Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82574135
162Abnormality of the hepatic vasculature (HP:0006707)1.81797877
163Poikiloderma (HP:0001029)1.81623062
164Tubulointerstitial fibrosis (HP:0005576)1.81598337
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80975121
166Colon cancer (HP:0003003)1.80785839
167Progressive macrocephaly (HP:0004481)1.79996361
168Abnormality of vitamin B metabolism (HP:0004340)1.79335502
169Genetic anticipation (HP:0003743)1.79181143
170Abnormality of the middle phalanges of the toes (HP:0010183)1.79005183
171Albinism (HP:0001022)1.78973549
172Methylmalonic aciduria (HP:0012120)1.78885358
173Sclerocornea (HP:0000647)1.78384185
174Nephroblastoma (Wilms tumor) (HP:0002667)1.78349457
175Aplasia/hypoplasia of the uterus (HP:0008684)1.77860827
176Growth hormone excess (HP:0000845)1.76123952
177Hypomagnesemia (HP:0002917)1.75788954
178Broad face (HP:0000283)1.75695967
179Embryonal neoplasm (HP:0002898)1.75658022
180Renal hypoplasia (HP:0000089)1.75338073
181Short foot (HP:0001773)1.74896379
182Thyroiditis (HP:0100646)1.74692582
183Birth length less than 3rd percentile (HP:0003561)1.73868755
184Atonic seizures (HP:0010819)1.73250253
185Aplasia/Hypoplasia of the lens (HP:0008063)1.71812667
186Supernumerary spleens (HP:0009799)1.71250146
187Chest pain (HP:0100749)1.70854786
188Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70599526
189Short phalanx of the thumb (HP:0009660)1.70491007
190Abnormality of the renal collecting system (HP:0004742)1.69664661
191Erythema (HP:0010783)1.68441251
192Specific learning disability (HP:0001328)1.67426780
193Ketosis (HP:0001946)1.66141142
194Progressive cerebellar ataxia (HP:0002073)1.65979680
195Occipital encephalocele (HP:0002085)1.65186942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.26268106
2KIT3.75883475
3TIE13.39950809
4MAP4K23.34494931
5STK162.83501044
6MKNK12.74363120
7TGFBR12.62167656
8FLT32.52666455
9BTK2.44211762
10TNIK2.43791191
11TEC2.37601889
12MATK2.37293892
13ACVR1B2.32895676
14MAP2K32.18644095
15PLK22.17138614
16TAOK32.06082446
17STK241.97807410
18GRK11.93577186
19PKN21.92828211
20WNK31.91724705
21MAP4K11.91291886
22PASK1.74103403
23MKNK21.73462328
24TXK1.71092184
25CSNK1G11.70198516
26AKT31.70129642
27INSRR1.66781537
28TLK11.65845126
29MAP3K41.60849961
30FER1.58559420
31WEE11.58024342
32EEF2K1.57558903
33IRAK41.57501706
34FGFR21.55728659
35MAP3K121.53352442
36CSF1R1.50373188
37CSNK1G31.49575509
38MAPK131.47311253
39CSNK1G21.47151345
40JAK31.44762237
41CDK81.44109411
42PIM21.41954289
43MYLK1.40966161
44NEK91.38605128
45VRK11.37247867
46CASK1.36422692
47MUSK1.34917026
48RPS6KB21.33892654
49CLK11.33611797
50NME21.30520817
51CSNK1A1L1.25845902
52MAPKAPK51.21474460
53ZAP701.19167260
54PRKCE1.18655010
55TRIM281.16267374
56ZAK1.15182854
57MAP3K61.14190380
58MAP2K61.12887777
59ATR1.12642380
60BCR1.11533004
61ADRBK11.10594457
62PAK31.10224101
63TGFBR21.09778010
64NUAK11.08178727
65TRPM71.07855657
66PTK2B1.07809624
67TNK21.04246840
68SRPK11.03768654
69IKBKE1.03753908
70DYRK21.02083373
71CDK191.00611378
72MST40.98156795
73DYRK30.93825605
74NLK0.93507951
75PIM10.92767036
76BRSK20.92151979
77DAPK20.90820078
78CDK70.90580141
79HIPK20.90180240
80PIK3CA0.89733175
81STK38L0.88616020
82BLK0.88445134
83STK390.85358478
84PIK3CG0.85079526
85SYK0.84067354
86LYN0.81891520
87CCNB10.79629269
88PHKG10.79360225
89PHKG20.79360225
90IRAK10.76397233
91TBK10.76228495
92IKBKB0.75963727
93RPS6KA60.75895096
94BRD40.75306288
95TAOK20.74598766
96PRKCG0.73188872
97BCKDK0.72857306
98OXSR10.72180023
99LCK0.69868680
100PKN10.68081972
101GRK70.68065962
102EPHA30.67860699
103GRK50.67590643
104ERBB30.66815478
105CHUK0.66578161
106ADRBK20.64193948
107CAMK2A0.62557881
108MARK10.59790658
109NTRK30.58998973
110PRKG20.58944118
111ROCK10.58510145
112MAPKAPK30.58434064
113EIF2AK30.57875761
114FES0.57698311
115PLK30.57447153
116RPS6KC10.56110028
117RPS6KL10.56110028
118RPS6KA50.56082896
119ILK0.54805065
120STK30.49121509
121YES10.47737709
122PAK40.46414019
123MAPK30.46325765
124BUB10.46318813
125DYRK1A0.45857349
126PLK40.45842325
127CDC70.45072369
128PRKAA10.44859221
129BMPR1B0.43089519
130MAP2K70.42786954
131SGK20.42272474
132PRKACA0.41469548
133RPS6KA40.40332211
134CSNK1A10.40267860
135MAPK40.39439583
136CAMK10.38588066
137PRKCQ0.37989821
138RPS6KB10.37966895
139PNCK0.37333538
140TRIB30.36991161
141ERBB20.36860874
142PRKG10.35669675
143CSNK1D0.35640642
144PINK10.35366525
145EPHA40.34423528
146NTRK20.34346274
147PRKCA0.34003865
148ABL10.33839390
149OBSCN0.32299475
150MAP3K140.32074995
151ATM0.31109551
152NEK60.30533934
153EPHB20.30507456
154STK40.29813887
155CAMKK20.29781493
156PAK20.29688947
157EIF2AK20.29491588
158IGF1R0.28154795
159MAPK150.28083458
160CAMK2D0.27425287
161MINK10.26414811
162LATS10.26171690
163GSK3A0.25783230

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86864354
2Ribosome_Homo sapiens_hsa030103.42981241
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.25408318
4Base excision repair_Homo sapiens_hsa034103.12701148
5Mismatch repair_Homo sapiens_hsa034303.03080833
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68107359
7Butanoate metabolism_Homo sapiens_hsa006502.42445302
8Nucleotide excision repair_Homo sapiens_hsa034202.36247698
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29934498
10Homologous recombination_Homo sapiens_hsa034402.27776639
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11639942
12* Transcriptional misregulation in cancer_Homo sapiens_hsa052022.07656700
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07042193
14Spliceosome_Homo sapiens_hsa030401.99678140
15Nitrogen metabolism_Homo sapiens_hsa009101.94718378
16Regulation of autophagy_Homo sapiens_hsa041401.93119705
17RNA polymerase_Homo sapiens_hsa030201.90526251
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89763726
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89625965
20RNA degradation_Homo sapiens_hsa030181.84485579
21Pyrimidine metabolism_Homo sapiens_hsa002401.81939216
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80585135
23Nicotine addiction_Homo sapiens_hsa050331.79599172
24Non-homologous end-joining_Homo sapiens_hsa034501.78441085
25Protein export_Homo sapiens_hsa030601.72378265
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72184444
27Sulfur metabolism_Homo sapiens_hsa009201.71301482
28Basal transcription factors_Homo sapiens_hsa030221.70391928
29Linoleic acid metabolism_Homo sapiens_hsa005911.66130243
30Cell cycle_Homo sapiens_hsa041101.64815500
31Thyroid cancer_Homo sapiens_hsa052161.63818810
32Herpes simplex infection_Homo sapiens_hsa051681.61135135
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60051551
34Acute myeloid leukemia_Homo sapiens_hsa052211.59553739
35Propanoate metabolism_Homo sapiens_hsa006401.57755493
36Fatty acid elongation_Homo sapiens_hsa000621.56231076
37Primary immunodeficiency_Homo sapiens_hsa053401.54698050
38Circadian entrainment_Homo sapiens_hsa047131.54667895
39Insulin secretion_Homo sapiens_hsa049111.52370094
40Taste transduction_Homo sapiens_hsa047421.52099834
41Platelet activation_Homo sapiens_hsa046111.50665502
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49948127
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49193229
44N-Glycan biosynthesis_Homo sapiens_hsa005101.47553315
45Tryptophan metabolism_Homo sapiens_hsa003801.43683508
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42714615
47Fanconi anemia pathway_Homo sapiens_hsa034601.41646459
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41108730
49Selenocompound metabolism_Homo sapiens_hsa004501.40105490
50Leishmaniasis_Homo sapiens_hsa051401.39747324
51Measles_Homo sapiens_hsa051621.38396335
52Ether lipid metabolism_Homo sapiens_hsa005651.38082444
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34025703
54Peroxisome_Homo sapiens_hsa041461.33536195
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32911836
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.29392707
57Serotonergic synapse_Homo sapiens_hsa047261.28681655
58Morphine addiction_Homo sapiens_hsa050321.27182139
59Hematopoietic cell lineage_Homo sapiens_hsa046401.26578013
60B cell receptor signaling pathway_Homo sapiens_hsa046621.23494200
61Circadian rhythm_Homo sapiens_hsa047101.23242444
62Renin secretion_Homo sapiens_hsa049241.21454543
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19036882
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.18194118
65Purine metabolism_Homo sapiens_hsa002301.17890427
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17754426
67Salivary secretion_Homo sapiens_hsa049701.15969544
68SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14635811
69GABAergic synapse_Homo sapiens_hsa047271.11378852
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.10431252
71Systemic lupus erythematosus_Homo sapiens_hsa053221.09850631
72Chemical carcinogenesis_Homo sapiens_hsa052041.08175005
73mRNA surveillance pathway_Homo sapiens_hsa030151.08106242
74Alcoholism_Homo sapiens_hsa050341.07599910
75Olfactory transduction_Homo sapiens_hsa047401.05535146
76Collecting duct acid secretion_Homo sapiens_hsa049661.05081666
77Ovarian steroidogenesis_Homo sapiens_hsa049131.03060051
78Glutamatergic synapse_Homo sapiens_hsa047241.01942589
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01515583
80Vascular smooth muscle contraction_Homo sapiens_hsa042701.00996744
81Retinol metabolism_Homo sapiens_hsa008301.00036948
82One carbon pool by folate_Homo sapiens_hsa006700.99069385
83Calcium signaling pathway_Homo sapiens_hsa040200.97435241
84Chronic myeloid leukemia_Homo sapiens_hsa052200.96034703
85Hepatitis B_Homo sapiens_hsa051610.95776661
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94815857
87TGF-beta signaling pathway_Homo sapiens_hsa043500.92655956
88RNA transport_Homo sapiens_hsa030130.92141145
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.91216230
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90961170
91Pancreatic secretion_Homo sapiens_hsa049720.90204899
92Legionellosis_Homo sapiens_hsa051340.89516973
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88160796
94Influenza A_Homo sapiens_hsa051640.86565242
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85502289
96p53 signaling pathway_Homo sapiens_hsa041150.84710853
97Other glycan degradation_Homo sapiens_hsa005110.84553281
98Long-term depression_Homo sapiens_hsa047300.83991409
99Hedgehog signaling pathway_Homo sapiens_hsa043400.83896453
100Non-small cell lung cancer_Homo sapiens_hsa052230.82092915
101Glycerolipid metabolism_Homo sapiens_hsa005610.81285470
102Shigellosis_Homo sapiens_hsa051310.81040231
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79949182
104Galactose metabolism_Homo sapiens_hsa000520.79887957
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79160228
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.78464393
107Dorso-ventral axis formation_Homo sapiens_hsa043200.77147011
108Arachidonic acid metabolism_Homo sapiens_hsa005900.76599503
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76356214
110Dopaminergic synapse_Homo sapiens_hsa047280.75968502
111Steroid biosynthesis_Homo sapiens_hsa001000.74051223
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73710833
113Notch signaling pathway_Homo sapiens_hsa043300.73009685
114Toxoplasmosis_Homo sapiens_hsa051450.72243107
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72029877
116Melanoma_Homo sapiens_hsa052180.71309571
117Antigen processing and presentation_Homo sapiens_hsa046120.70940729
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70043348
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68768420
120Cholinergic synapse_Homo sapiens_hsa047250.68676239
121HTLV-I infection_Homo sapiens_hsa051660.68074909
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67752635
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67423974
124Amphetamine addiction_Homo sapiens_hsa050310.65824100
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64819066
126Small cell lung cancer_Homo sapiens_hsa052220.63509068
127Epstein-Barr virus infection_Homo sapiens_hsa051690.63291666
128beta-Alanine metabolism_Homo sapiens_hsa004100.62645358
129Apoptosis_Homo sapiens_hsa042100.62154246
130Oxytocin signaling pathway_Homo sapiens_hsa049210.61835361
131Prolactin signaling pathway_Homo sapiens_hsa049170.61727635
132Fatty acid metabolism_Homo sapiens_hsa012120.61510611
133Viral carcinogenesis_Homo sapiens_hsa052030.61223831
134Oxidative phosphorylation_Homo sapiens_hsa001900.60970161
135Protein digestion and absorption_Homo sapiens_hsa049740.60212864
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.59972024
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56897234
138Osteoclast differentiation_Homo sapiens_hsa043800.56234663
139Pathways in cancer_Homo sapiens_hsa052000.54905058
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53768701
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53699702
142Type II diabetes mellitus_Homo sapiens_hsa049300.53635703
143TNF signaling pathway_Homo sapiens_hsa046680.53091850
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52891835
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52842184
146Dilated cardiomyopathy_Homo sapiens_hsa054140.52140083
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50609851
148Cardiac muscle contraction_Homo sapiens_hsa042600.50529742
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.50113725
150HIF-1 signaling pathway_Homo sapiens_hsa040660.49632044
151Caffeine metabolism_Homo sapiens_hsa002320.49116405
152cAMP signaling pathway_Homo sapiens_hsa040240.48891726
153Cocaine addiction_Homo sapiens_hsa050300.48568368
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.47912954
155Pertussis_Homo sapiens_hsa051330.47617975
156ABC transporters_Homo sapiens_hsa020100.47428952
157Fatty acid degradation_Homo sapiens_hsa000710.47299756
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45789412
159MicroRNAs in cancer_Homo sapiens_hsa052060.45407661
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45085512
161Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45077839
162ECM-receptor interaction_Homo sapiens_hsa045120.44968311
163Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44270619
164AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42750655
165Gap junction_Homo sapiens_hsa045400.42278928
166Hepatitis C_Homo sapiens_hsa051600.41932463
167Renin-angiotensin system_Homo sapiens_hsa046140.39998755
168Folate biosynthesis_Homo sapiens_hsa007900.39811241
169Malaria_Homo sapiens_hsa051440.39617522
170Ras signaling pathway_Homo sapiens_hsa040140.39254505
171Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39106423
172Pancreatic cancer_Homo sapiens_hsa052120.37798074
173Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33723537
174Colorectal cancer_Homo sapiens_hsa052100.33002180
175Drug metabolism - other enzymes_Homo sapiens_hsa009830.32784969
176Phototransduction_Homo sapiens_hsa047440.30794225
177Neurotrophin signaling pathway_Homo sapiens_hsa047220.29987041
178Allograft rejection_Homo sapiens_hsa053300.26220556
179Fructose and mannose metabolism_Homo sapiens_hsa000510.25939827
180Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25446207
181Lysine degradation_Homo sapiens_hsa003100.24132059
182Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24100304

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »