MEGF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.09524367
2protein heterotrimerization (GO:0070208)5.88054547
3planar cell polarity pathway involved in neural tube closure (GO:0090179)5.45645578
4bone trabecula formation (GO:0060346)5.33863762
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.07224964
6lateral sprouting from an epithelium (GO:0060601)4.89126225
7outer ear morphogenesis (GO:0042473)4.61695908
8paraxial mesoderm development (GO:0048339)4.56060922
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.20168900
10anatomical structure regression (GO:0060033)4.19706638
11endodermal cell differentiation (GO:0035987)4.14863159
12regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.10296714
13lung-associated mesenchyme development (GO:0060484)4.08368918
14collagen metabolic process (GO:0032963)3.97372095
15collagen catabolic process (GO:0030574)3.94835901
16desmosome organization (GO:0002934)3.94779874
17collagen fibril organization (GO:0030199)3.93770096
18polarized epithelial cell differentiation (GO:0030859)3.89103708
19non-canonical Wnt signaling pathway (GO:0035567)3.87215848
20axon extension involved in axon guidance (GO:0048846)3.85830177
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.85830177
22negative regulation of chondrocyte differentiation (GO:0032331)3.83481226
23multicellular organismal macromolecule metabolic process (GO:0044259)3.74869534
24Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.69736901
25cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.63899046
26multicellular organismal catabolic process (GO:0044243)3.63411946
27mesenchyme morphogenesis (GO:0072132)3.62110840
28establishment of planar polarity (GO:0001736)3.61437479
29establishment of tissue polarity (GO:0007164)3.61437479
30pattern specification involved in kidney development (GO:0061004)3.59550285
31cell proliferation involved in metanephros development (GO:0072203)3.57643343
32extracellular matrix disassembly (GO:0022617)3.54665404
33regulation of establishment of planar polarity (GO:0090175)3.53998643
34cochlea morphogenesis (GO:0090103)3.50999560
35endocardial cushion morphogenesis (GO:0003203)3.50166080
36hippo signaling (GO:0035329)3.49368126
37mannose metabolic process (GO:0006013)3.49342440
38multicellular organismal metabolic process (GO:0044236)3.49111272
39negative regulation of catenin import into nucleus (GO:0035414)3.49078931
40cell-substrate junction assembly (GO:0007044)3.48975884
41mesenchymal cell proliferation (GO:0010463)3.46575216
42negative regulation of fatty acid transport (GO:2000192)3.44098548
43branching involved in salivary gland morphogenesis (GO:0060445)3.44058050
44stress fiber assembly (GO:0043149)3.43190548
45negative regulation of cartilage development (GO:0061037)3.40301918
46embryonic cranial skeleton morphogenesis (GO:0048701)3.39966863
47regulation of heart morphogenesis (GO:2000826)3.37947080
48negative regulation of cell fate specification (GO:0009996)3.37306797
49positive regulation of blood vessel endothelial cell migration (GO:0043536)3.36416076
50collecting duct development (GO:0072044)3.35737226
51establishment of apical/basal cell polarity (GO:0035089)3.35236166
52skin morphogenesis (GO:0043589)3.32427951
53proximal/distal pattern formation (GO:0009954)3.30609313
54negative regulation of erythrocyte differentiation (GO:0045647)3.30218967
55vascular endothelial growth factor signaling pathway (GO:0038084)3.28709879
56bone morphogenesis (GO:0060349)3.25460902
57head development (GO:0060322)3.22919788
58regulation of extracellular matrix disassembly (GO:0010715)3.22078037
59middle ear morphogenesis (GO:0042474)3.22059998
60craniofacial suture morphogenesis (GO:0097094)3.20889581
61glomerular basement membrane development (GO:0032836)3.20590656
62negative regulation of embryonic development (GO:0045992)3.20549983
63virion attachment to host cell (GO:0019062)3.19397555
64adhesion of symbiont to host cell (GO:0044650)3.19397555
65regulation of transforming growth factor beta2 production (GO:0032909)3.18410376
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16578321
67hair cycle (GO:0042633)3.13917696
68molting cycle (GO:0042303)3.13917696
69regulation of hair follicle development (GO:0051797)3.11981347
70extracellular fibril organization (GO:0043206)3.10947241
71cell proliferation involved in kidney development (GO:0072111)3.09550060
72renal system development (GO:0072001)3.07979423
73blood vessel maturation (GO:0001955)3.07519027
74vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.07185343
75positive regulation of epithelial to mesenchymal transition (GO:0010718)3.07034748
76adherens junction assembly (GO:0034333)3.06948957
77basement membrane organization (GO:0071711)3.06919744
78type B pancreatic cell proliferation (GO:0044342)3.06017839
79extracellular matrix assembly (GO:0085029)3.05508407
80cell-substrate adherens junction assembly (GO:0007045)3.04241905
81focal adhesion assembly (GO:0048041)3.04241905
82mesenchyme development (GO:0060485)3.04092073
83positive regulation of mesenchymal cell proliferation (GO:0002053)3.03798749
84negative regulation of axon extension involved in axon guidance (GO:0048843)3.00420270
85digestive tract morphogenesis (GO:0048546)2.98569855
86axis elongation (GO:0003401)2.98385142
87barbed-end actin filament capping (GO:0051016)2.98100650
88cell surface receptor signaling pathway involved in heart development (GO:0061311)2.96742344
89bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96079906
90wound healing, spreading of epidermal cells (GO:0035313)2.95102928
91embryonic skeletal joint morphogenesis (GO:0060272)2.93185953
92atrioventricular valve morphogenesis (GO:0003181)2.91318321
93odontogenesis (GO:0042476)2.90154711
94positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89385069
95convergent extension (GO:0060026)2.88800934
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88543002
97negative regulation of smooth muscle cell migration (GO:0014912)2.87908530
98regulation of mesenchymal cell proliferation (GO:0010464)2.87647820
99positive regulation of receptor recycling (GO:0001921)2.87340683
100epithelial cell fate commitment (GO:0072148)2.87292737
101regulation of cardioblast proliferation (GO:0003264)2.87168231
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.87168231
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86153861
104embryonic camera-type eye development (GO:0031076)2.86025961
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.85058546
106establishment of monopolar cell polarity (GO:0061162)2.85058546
107skin development (GO:0043588)2.83617078
108semaphorin-plexin signaling pathway (GO:0071526)2.83171308
109venous blood vessel morphogenesis (GO:0048845)2.82657874
110substrate-dependent cell migration (GO:0006929)2.82470256
111regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.82413816
112trabecula formation (GO:0060343)2.82334199
113cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.81824587
114regulation of hippo signaling (GO:0035330)2.80198527
115cranial suture morphogenesis (GO:0060363)2.79240333
116lymph vessel development (GO:0001945)2.78790354
117cell migration involved in heart development (GO:0060973)2.78333048
118mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78111927
119sequestering of extracellular ligand from receptor (GO:0035581)2.77003325
120regulation of cardioblast differentiation (GO:0051890)2.76630980
121eyelid development in camera-type eye (GO:0061029)2.75747180
122epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75695346
123positive regulation of smoothened signaling pathway (GO:0045880)2.75093021
124mesodermal cell differentiation (GO:0048333)2.74956479
125negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.72967805
126adhesion of symbiont to host (GO:0044406)2.72706277
127response to laminar fluid shear stress (GO:0034616)2.71208332
128fibril organization (GO:0097435)2.70635956
129endothelial cell morphogenesis (GO:0001886)2.67696448
130positive regulation of histone deacetylation (GO:0031065)2.64852474
131epithelial cell-cell adhesion (GO:0090136)2.63070363
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.62233752
133cell adhesion mediated by integrin (GO:0033627)2.60456076
134chondroitin sulfate biosynthetic process (GO:0030206)2.58957020
135response to fluid shear stress (GO:0034405)2.57584773
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.57470367
137hypotonic response (GO:0006971)2.56794132
138dermatan sulfate metabolic process (GO:0030205)2.52877819
139hyaluronan catabolic process (GO:0030214)2.51860092
140renal filtration (GO:0097205)2.50199048
141apoptotic process involved in morphogenesis (GO:0060561)2.48441704
142apoptotic cell clearance (GO:0043277)2.45563956
143extracellular matrix organization (GO:0030198)2.41982122
144extracellular structure organization (GO:0043062)2.40887900
145activation of JUN kinase activity (GO:0007257)2.40549303
146positive regulation of osteoblast proliferation (GO:0033690)2.39146274
147positive regulation of extracellular matrix organization (GO:1903055)2.39102936
148protein localization to endosome (GO:0036010)2.37979693
149embryonic process involved in female pregnancy (GO:0060136)2.35293145
150tooth mineralization (GO:0034505)2.34672695
151regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.34060805
152activation of Rac GTPase activity (GO:0032863)2.32269127
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31689848
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31159081
155endothelial cell chemotaxis (GO:0035767)2.30699254
156integrin-mediated signaling pathway (GO:0007229)2.29815515
157negative regulation of osteoblast proliferation (GO:0033689)2.29703599
158peptide cross-linking (GO:0018149)2.27961329
159positive regulation of endothelial cell migration (GO:0010595)2.25961036
160positive regulation of Cdc42 GTPase activity (GO:0043089)2.25631986
161negative regulation of granulocyte differentiation (GO:0030853)2.24002891
162chondrocyte proliferation (GO:0035988)2.23322804
163regulation of blood vessel endothelial cell migration (GO:0043535)2.22469482
164cell migration involved in sprouting angiogenesis (GO:0002042)2.22441306
165negative regulation of osteoblast differentiation (GO:0045668)2.22338113
166endocardial cushion development (GO:0003197)2.22307486
167negative regulation of interleukin-8 production (GO:0032717)2.21863234
168regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21711155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.98073258
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.23256291
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.18714989
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61275836
5EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.42585735
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40687373
7ZNF263_19887448_ChIP-Seq_K562_Human2.33802992
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29869953
9VDR_21846776_ChIP-Seq_THP-1_Human2.29252917
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23439027
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12524395
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.12358004
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11970704
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11970704
15TP53_20018659_ChIP-ChIP_R1E_Mouse2.10055429
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07742963
17CLOCK_20551151_ChIP-Seq_293T_Human2.03514632
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97186235
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.95282558
20* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.88402428
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85105556
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83330931
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.81946783
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79799962
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76776888
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73881646
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.72932204
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71305641
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68933792
30ISL1_27105846_Chip-Seq_CPCs_Mouse1.68096549
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67807931
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.67593885
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.65930308
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65114127
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.64702692
36MYC_22102868_ChIP-Seq_BL_Human1.64587213
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64054615
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63017217
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62462950
40* KDM2B_26808549_Chip-Seq_K562_Human1.62452318
41VDR_24763502_ChIP-Seq_THP-1_Human1.62155234
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61463963
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60140713
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60062818
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54490602
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.53140332
47* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52715022
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52302614
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52202564
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51135031
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50981968
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50357510
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50201536
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.49666481
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.47633992
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46809566
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.45106882
58RACK7_27058665_Chip-Seq_MCF-7_Human1.44561149
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43819629
60TP53_22127205_ChIP-Seq_IMR90_Human1.42667045
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41615225
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.41417121
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.40409927
64LXR_22292898_ChIP-Seq_THP-1_Human1.40285562
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38035233
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.37638797
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35790840
68* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35202542
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34023471
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30965399
71* KDM2B_26808549_Chip-Seq_DND41_Human1.30547697
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27654451
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27446335
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26827039
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26583249
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.26497421
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26382375
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.24657648
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24342273
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.23941530
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23587959
82MAF_26560356_Chip-Seq_TH1_Human1.23579402
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21817483
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21311248
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.21029388
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20087354
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.20051068
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18697302
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18299872
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18299872
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18299872
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18130458
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.17918767
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17514268
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17507086
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15465716
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15369234
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.15346797
99* SMC4_20622854_ChIP-Seq_HELA_Human1.14727679
100UTX_26944678_Chip-Seq_JUKART_Human1.14373992
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13652797
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13335265
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13335265
104TP53_23651856_ChIP-Seq_MEFs_Mouse1.12463899
105SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12348206
106* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12134629
107* CTCF_27219007_Chip-Seq_Bcells_Human1.12021073
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09541635
109CJUN_26792858_Chip-Seq_BT549_Human1.09505074
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09263995
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.08735704
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08727853
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08636949
114* P68_20966046_ChIP-Seq_HELA_Human1.07994642
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07259862
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06805722
117SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06187124
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05741111
119* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04873942
120DROSHA_22980978_ChIP-Seq_HELA_Human1.04696633
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04373513
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.04345364
123TBX20_22328084_ChIP-Seq_HEART_Mouse1.04345364
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04018049
125* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03999306
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.03843835
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.03721891
128MAF_26560356_Chip-Seq_TH2_Human1.03674663
129ATF3_27146783_Chip-Seq_COLON_Human1.03449583
130SPI1_23127762_ChIP-Seq_K562_Human1.00326368
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99324468
132CREB1_26743006_Chip-Seq_LNCaP_Human0.99166645
133TCF7_22412390_ChIP-Seq_EML_Mouse0.99101730
134* TP63_22573176_ChIP-Seq_HFKS_Human0.98516946
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98435680
136SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97983278
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96723591
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96535854
139NCOR1_26117541_ChIP-Seq_K562_Human0.96192263
140BRD4_25478319_ChIP-Seq_HGPS_Human0.96169184
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94647945
142* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94572198
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93773079
144AR_21572438_ChIP-Seq_LNCaP_Human0.93692789
145GATA1_19941826_ChIP-Seq_K562_Human0.93665603
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.92789957
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92049962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.56937079
2MP0005275_abnormal_skin_tensile4.06721173
3MP0003705_abnormal_hypodermis_morpholog3.48056605
4MP0010030_abnormal_orbit_morphology3.37293619
5MP0004272_abnormal_basement_membrane3.13901141
6MP0000579_abnormal_nail_morphology2.71909083
7MP0000537_abnormal_urethra_morphology2.61763899
8MP0005503_abnormal_tendon_morphology2.46981292
9MP0006054_spinal_hemorrhage2.38279072
10MP0002060_abnormal_skin_morphology2.35878007
11MP0000762_abnormal_tongue_morphology2.35433887
12MP0009053_abnormal_anal_canal2.35349889
13MP0001958_emphysema2.29753507
14MP0003091_abnormal_cell_migration2.14484251
15MP0003385_abnormal_body_wall2.09434249
16MP0010234_abnormal_vibrissa_follicle2.05808482
17MP0009250_abnormal_appendicular_skeleto2.03950858
18MP0001849_ear_inflammation2.02904088
19MP0002234_abnormal_pharynx_morphology1.95537767
20MP0000383_abnormal_hair_follicle1.91972343
21MP0001243_abnormal_dermal_layer1.81207712
22MP0003941_abnormal_skin_development1.81043169
23MP0005367_renal/urinary_system_phenotyp1.80668985
24MP0000516_abnormal_urinary_system1.80668985
25MP0002282_abnormal_trachea_morphology1.80275231
26MP0002098_abnormal_vibrissa_morphology1.80081799
27MP0005508_abnormal_skeleton_morphology1.78410763
28MP0000733_abnormal_muscle_development1.77185305
29MP0002249_abnormal_larynx_morphology1.76722569
30MP0005623_abnormal_meninges_morphology1.75935998
31MP0002933_joint_inflammation1.75334170
32MP0000049_abnormal_middle_ear1.72022339
33MP0000462_abnormal_digestive_system1.71121138
34MP0002932_abnormal_joint_morphology1.69487125
35MP0010678_abnormal_skin_adnexa1.69468912
36MP0000566_synostosis1.69083140
37MP0001542_abnormal_bone_strength1.67543124
38MP0002254_reproductive_system_inflammat1.66516352
39MP0000467_abnormal_esophagus_morphology1.63950952
40MP0000428_abnormal_craniofacial_morphol1.61519712
41MP0005058_abnormal_lysosome_morphology1.60272762
42MP0003755_abnormal_palate_morphology1.59890090
43MP0003942_abnormal_urinary_system1.59341801
44MP0003300_gastrointestinal_ulcer1.58484664
45MP0003279_aneurysm1.58121515
46MP0001346_abnormal_lacrimal_gland1.57067087
47MP0000534_abnormal_ureter_morphology1.51399776
48MP0003122_maternal_imprinting1.51327586
49MP0005257_abnormal_intraocular_pressure1.49918950
50MP0003115_abnormal_respiratory_system1.49658200
51MP0003937_abnormal_limbs/digits/tail_de1.46646746
52MP0002938_white_spotting1.46529909
53MP0003935_abnormal_craniofacial_develop1.46134927
54MP0005390_skeleton_phenotype1.46026849
55MP0002233_abnormal_nose_morphology1.43431470
56MP0002796_impaired_skin_barrier1.42926942
57MP0003436_decreased_susceptibility_to1.42430940
58MP0003172_abnormal_lysosome_physiology1.41161647
59MP0003566_abnormal_cell_adhesion1.34759701
60MP0002896_abnormal_bone_mineralization1.32171832
61MP0002116_abnormal_craniofacial_bone1.29965508
62MP0003191_abnormal_cellular_cholesterol1.28669202
63MP0010368_abnormal_lymphatic_system1.28606488
64MP0002998_abnormal_bone_remodeling1.28266390
65MP0005076_abnormal_cell_differentiation1.27542817
66MP0003453_abnormal_keratinocyte_physiol1.27297790
67MP0000377_abnormal_hair_follicle1.25612302
68MP0001216_abnormal_epidermal_layer1.23517470
69MP0001299_abnormal_eye_distance/1.23482512
70MP0001340_abnormal_eyelid_morphology1.22198122
71MP0003283_abnormal_digestive_organ1.22167355
72MP0000432_abnormal_head_morphology1.19550372
73MP0002111_abnormal_tail_morphology1.19230936
74MP0002109_abnormal_limb_morphology1.17622235
75MP0001879_abnormal_lymphatic_vessel1.15580834
76MP0001533_abnormal_skeleton_physiology1.15453960
77MP0010771_integument_phenotype1.15220680
78MP0003828_pulmonary_edema1.14385658
79MP0005595_abnormal_vascular_smooth1.14344464
80MP0002653_abnormal_ependyma_morphology1.12960254
81MP0000163_abnormal_cartilage_morphology1.11571317
82MP0002115_abnormal_skeleton_extremities1.11237768
83MP0004947_skin_inflammation1.09981523
84MP0000647_abnormal_sebaceous_gland1.08096962
85MP0000013_abnormal_adipose_tissue1.06347813
86MP0009384_cardiac_valve_regurgitation1.03317793
87MP0005248_abnormal_Harderian_gland1.03163182
88MP0003123_paternal_imprinting1.02024391
89MP0002108_abnormal_muscle_morphology1.01119799
90MP0005409_darkened_coat_color1.00702309
91MP0003119_abnormal_digestive_system0.98389887
92MP0008260_abnormal_autophagy0.97004609
93MP0000858_altered_metastatic_potential0.96994944
94MP0002177_abnormal_outer_ear0.96362737
95MP0000427_abnormal_hair_cycle0.95974549
96MP0003303_peritoneal_inflammation0.95656816
97MP0000767_abnormal_smooth_muscle0.94837710
98MP0005164_abnormal_response_to0.93411352
99MP0002697_abnormal_eye_size0.93226819
100MP0005187_abnormal_penis_morphology0.92884666
101MP0001614_abnormal_blood_vessel0.90702932
102MP0005501_abnormal_skin_physiology0.89938579
103MP0005023_abnormal_wound_healing0.88256356
104MP0002295_abnormal_pulmonary_circulatio0.88191609
105MP0001270_distended_abdomen0.87564286
106MP0002877_abnormal_melanocyte_morpholog0.86379926
107MP0001348_abnormal_lacrimal_gland0.86305729
108MP0010352_gastrointestinal_tract_polyps0.85804225
109MP0002113_abnormal_skeleton_development0.84612026
110MP0000751_myopathy0.84480155
111MP0002092_abnormal_eye_morphology0.84006195
112MP0005388_respiratory_system_phenotype0.83803915
113MP0002133_abnormal_respiratory_system0.83803915
114MP0003795_abnormal_bone_structure0.83266626
115MP0002114_abnormal_axial_skeleton0.81962618
116MP0003724_increased_susceptibility_to0.80601092
117MP0002128_abnormal_blood_circulation0.80479635
118MP0001293_anophthalmia0.80066345
119MP0006138_congestive_heart_failure0.79382768
120MP0004858_abnormal_nervous_system0.79022822
121MP0008789_abnormal_olfactory_epithelium0.78407286
122MP0002925_abnormal_cardiovascular_devel0.77274657
123MP0004883_abnormal_blood_vessel0.76829208
124MP0000003_abnormal_adipose_tissue0.76392522
125MP0009278_abnormal_bone_marrow0.75642714
126MP0004197_abnormal_fetal_growth/weight/0.75514797
127MP0001286_abnormal_eye_development0.75266871
128MP0004134_abnormal_chest_morphology0.74397957
129MP0001175_abnormal_lung_morphology0.74150286
130MP0003448_altered_tumor_morphology0.73485249
131MP0001177_atelectasis0.72732289
132MP0000759_abnormal_skeletal_muscle0.72711744
133MP0009840_abnormal_foam_cell0.71985061
134MP0009931_abnormal_skin_appearance0.71074887
135MP0000249_abnormal_blood_vessel0.71026504
136MP0001915_intracranial_hemorrhage0.70350189
137MP0002419_abnormal_innate_immunity0.67807031
138MP0001851_eye_inflammation0.67408599
139MP0003045_fibrosis0.65124776
140MP0000538_abnormal_urinary_bladder0.64152264
141MP0005375_adipose_tissue_phenotype0.63168037
142MP0005193_abnormal_anterior_eye0.62126217

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)6.52748316
2Milia (HP:0001056)6.35781406
3Premature rupture of membranes (HP:0001788)5.29409850
4Fragile skin (HP:0001030)4.76560463
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.71482400
6Short 4th metacarpal (HP:0010044)4.71482400
7Protrusio acetabuli (HP:0003179)4.32532845
8Shallow orbits (HP:0000586)4.20693610
9Aortic aneurysm (HP:0004942)4.18839461
10Ankle contracture (HP:0006466)4.11508507
11Cervical subluxation (HP:0003308)3.96849609
12Abnormality of the 4th metacarpal (HP:0010012)3.82345712
13Abnormality of the parietal bone (HP:0002696)3.72978413
14Bladder diverticulum (HP:0000015)3.68038855
15Follicular hyperkeratosis (HP:0007502)3.55762511
16Vascular tortuosity (HP:0004948)3.50482878
17Ankyloglossia (HP:0010296)3.42961718
18Down-sloping shoulders (HP:0200021)3.42749224
19Fragile nails (HP:0001808)3.41967191
20Type 1 muscle fiber predominance (HP:0003803)3.40897259
21Broad metatarsal (HP:0001783)3.23391359
22Arterial tortuosity (HP:0005116)3.14267674
23Aortic dissection (HP:0002647)3.13516716
24Peritonitis (HP:0002586)3.12376302
25Spondylolisthesis (HP:0003302)3.07012351
26Aortic regurgitation (HP:0001659)2.98675043
27Neoplasm of the heart (HP:0100544)2.98659478
28Biconcave vertebral bodies (HP:0004586)2.97431662
29Cerebral aneurysm (HP:0004944)2.96705501
30Broad face (HP:0000283)2.89863910
31Soft skin (HP:0000977)2.87040985
32Mitral valve prolapse (HP:0001634)2.82464751
33Increased connective tissue (HP:0009025)2.81159226
34Neonatal short-limb short stature (HP:0008921)2.80227711
35Deviation of the hallux (HP:0010051)2.79915124
36Renal duplication (HP:0000075)2.78251721
37Onycholysis (HP:0001806)2.78045471
38Hallux valgus (HP:0001822)2.74354216
39Obstructive sleep apnea (HP:0002870)2.72856379
40Slender build (HP:0001533)2.72021911
41Vertebral compression fractures (HP:0002953)2.70352995
42Renovascular hypertension (HP:0100817)2.69450445
43Premature skin wrinkling (HP:0100678)2.68966092
44Mildly elevated creatine phosphokinase (HP:0008180)2.68136919
45Joint stiffness (HP:0001387)2.64332787
46Aneurysm (HP:0002617)2.61835544
47Abnormality of oral frenula (HP:0000190)2.61163193
48Thin bony cortex (HP:0002753)2.56176723
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.53639455
50Spinal rigidity (HP:0003306)2.51409471
51Coronal craniosynostosis (HP:0004440)2.51171590
52Dilatation of the ascending aorta (HP:0005111)2.51088886
53Plantar hyperkeratosis (HP:0007556)2.50696652
54Bowel diverticulosis (HP:0005222)2.46173219
55Genu recurvatum (HP:0002816)2.45851564
56Short phalanx of the thumb (HP:0009660)2.45600191
57Morphological abnormality of the middle ear (HP:0008609)2.45500916
58Overriding aorta (HP:0002623)2.43873017
59Disproportionate tall stature (HP:0001519)2.42943165
60Supernumerary ribs (HP:0005815)2.36858298
61Turricephaly (HP:0000262)2.35619168
62Hyperacusis (HP:0010780)2.33661020
63Absent eyelashes (HP:0000561)2.33605626
64Abnormality of dentin (HP:0010299)2.33160312
65Hypotrichosis (HP:0001006)2.32877839
66Selective tooth agenesis (HP:0001592)2.31513944
67Aortic valve stenosis (HP:0001650)2.31418923
68Blue sclerae (HP:0000592)2.29941819
69Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.29510730
70Overgrowth (HP:0001548)2.28705328
71Woolly hair (HP:0002224)2.28624556
72Pili torti (HP:0003777)2.26133917
73Ridged nail (HP:0001807)2.22806773
74Increased variability in muscle fiber diameter (HP:0003557)2.20956304
75Right ventricular cardiomyopathy (HP:0011663)2.20175103
76Flat cornea (HP:0007720)2.17659401
77Lymphangioma (HP:0100764)2.14951388
78Alopecia of scalp (HP:0002293)2.11832839
79Bronchomalacia (HP:0002780)2.11026144
80Abnormality of the acetabulum (HP:0003170)2.10641167
81Ulnar bowing (HP:0003031)2.06792468
82Supernumerary bones of the axial skeleton (HP:0009144)2.06552376
83Abnormality of the peritoneum (HP:0002585)2.05290020
84Elfin facies (HP:0004428)2.01897572
85Hyperextensible skin (HP:0000974)2.00829278
86Sprengel anomaly (HP:0000912)1.99956491
87Emphysema (HP:0002097)1.99874906
88Venous insufficiency (HP:0005293)1.96710132
89Distal lower limb amyotrophy (HP:0008944)1.94520396
90Wide anterior fontanel (HP:0000260)1.92631891
91Buphthalmos (HP:0000557)1.92360393
92Distal upper limb amyotrophy (HP:0007149)1.91596160
93Upper limb amyotrophy (HP:0009129)1.91596160
94Protruding ear (HP:0000411)1.90977369
95Interstitial pulmonary disease (HP:0006530)1.90960621
96Urinary glycosaminoglycan excretion (HP:0003541)1.90362545
97Mucopolysacchariduria (HP:0008155)1.90362545
98Skin pits (HP:0100276)1.89974935
99Mitral regurgitation (HP:0001653)1.89613979
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.89246370
101Osteolytic defects of the hand bones (HP:0009699)1.89246370
102Nail dystrophy (HP:0008404)1.88431235
103Midline defect of the nose (HP:0004122)1.87786231
104Abnormal ossification of hand bones (HP:0005921)1.85973848
105Venous abnormality (HP:0002624)1.85919656
106Dysostosis multiplex (HP:0000943)1.85105339
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84883166
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84883166
109Abnormality of polysaccharide metabolism (HP:0011012)1.84883166
110Abnormality of skeletal muscle fiber size (HP:0012084)1.82354655
111Joint laxity (HP:0001388)1.81553648
112Aplasia involving bones of the extremities (HP:0009825)1.81340273
113Aplasia involving bones of the upper limbs (HP:0009823)1.81340273
114Aplasia of the phalanges of the hand (HP:0009802)1.81340273
115Atresia of the external auditory canal (HP:0000413)1.81009475
116Persistence of primary teeth (HP:0006335)1.80412574
117Abnormality of the nasolacrimal system (HP:0000614)1.80406037
118Abnormality of the 2nd finger (HP:0004100)1.80050111
119Wormian bones (HP:0002645)1.79202301
120Elbow flexion contracture (HP:0002987)1.78428620
121Absent frontal sinuses (HP:0002688)1.78143718
122Abnormality of skull ossification (HP:0002703)1.77560649
123Inguinal hernia (HP:0000023)1.77000625
124Natal tooth (HP:0000695)1.76221730
125Short nail (HP:0001799)1.75410002
126Camptodactyly of toe (HP:0001836)1.75056373
127Broad toe (HP:0001837)1.74702698
128Wrist flexion contracture (HP:0001239)1.74215654
129Arnold-Chiari malformation (HP:0002308)1.73284548
130Asymmetry of the thorax (HP:0001555)1.73243056
131Round ear (HP:0100830)1.72962082
132Insomnia (HP:0100785)1.72550835
133Infantile muscular hypotonia (HP:0008947)1.72523706
134Ectopia lentis (HP:0001083)1.71816321
135Thick nail (HP:0001805)1.71221651
136Alacrima (HP:0000522)1.70997298
137Nonimmune hydrops fetalis (HP:0001790)1.70956120
138Coxa vara (HP:0002812)1.70276741
139Stridor (HP:0010307)1.69344345
140Hemorrhage of the eye (HP:0011885)1.68885796
141Joint contractures involving the joints of the feet (HP:0100492)1.68364455
142Flexion contracture of toe (HP:0005830)1.68364455
143Cutaneous finger syndactyly (HP:0010554)1.67379155
144Difficulty climbing stairs (HP:0003551)1.66766910
145Hypoplasia of the iris (HP:0007676)1.66433831
146Dislocated radial head (HP:0003083)1.65688087
147Spinal cord lesions (HP:0100561)1.65068820
148Syringomyelia (HP:0003396)1.65068820
149Mild short stature (HP:0003502)1.63886112
150Abnormal delivery (HP:0001787)1.63836440
151Long eyelashes (HP:0000527)1.63078559
152Flared iliac wings (HP:0002869)1.58589864
153Broad ribs (HP:0000885)1.58250328
154Abnormal vertebral ossification (HP:0100569)1.58076397
155Distal lower limb muscle weakness (HP:0009053)1.57739511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.50005848
2TRIB33.67331027
3FGFR23.55487722
4MAP3K103.38277808
5LATS13.22295920
6DDR22.94395775
7RIPK12.87263901
8PKN22.78591045
9PDGFRA2.76967932
10SIK12.62061246
11LATS22.18311076
12FER2.14660954
13MAPK152.05726921
14PTK62.02555731
15FGFR41.97152769
16TTN1.92307395
17MYLK1.91662906
18TIE11.90713763
19PRPF4B1.88006003
20EEF2K1.81603360
21MAP3K61.78763158
22MAP2K31.76513340
23SMG11.76362653
24FGFR11.68139713
25EPHA21.68106741
26PAK41.66165821
27ICK1.65191887
28MAP4K11.62627843
29LRRK21.50973579
30TYRO31.50025652
31ERN11.49074175
32BMX1.46127309
33EPHA31.45530448
34TGFBR21.38971615
35TGFBR11.38309534
36PTK21.32712647
37ILK1.29846847
38TYK21.24344257
39PAK21.24291697
40DMPK1.22571379
41ZAP701.22025078
42NEK91.20960989
43MAPK71.20953092
44KIT1.16621025
45ERBB21.12215637
46PDGFRB1.11475213
47STK381.10817171
48MET1.10251753
49TBK11.05082445
50MTOR1.03078021
51JAK31.02973750
52LMTK21.02524684
53TESK11.02493697
54MAP3K31.01953857
55EPHB11.01808231
56PRKCI1.01610518
57MAP3K131.01470191
58RPS6KB20.99373740
59IRAK30.99319734
60TNK20.97329617
61DYRK1B0.96719512
62CDK120.95599884
63CDK60.92624636
64MST1R0.90988779
65STK30.89293105
66HIPK20.89021034
67TRPM70.85832506
68BLK0.85129240
69RPS6KA60.83219876
70MAP2K20.81389096
71MAP3K70.78943289
72BTK0.78936326
73PRKD10.77705217
74FGFR30.77143147
75CDC42BPA0.76191720
76ROCK10.75636299
77FLT30.74667626
78JAK10.73989478
79ROCK20.70816065
80PIK3CG0.70370403
81MAP3K140.70241194
82PTK2B0.70214547
83CAMK1G0.68811029
84RET0.66833996
85CSK0.66347124
86IRAK40.65113855
87FES0.63644232
88MAP3K10.62560709
89GRK60.61811429
90HCK0.57509613
91KDR0.56161632
92MAP3K20.54891805
93PDPK10.54311052
94RPS6KA40.54001555
95CDK70.52508819
96MAPK120.51819733
97MELK0.51396466
98TAOK10.50749543
99DAPK30.48923010
100STK38L0.48472770
101NTRK20.48292872
102PRKD30.47986076
103CAMK1D0.46194449
104IKBKE0.45187591
105GSK3A0.44978030
106ITK0.44295011
107PAK30.43976831
108TLK10.43683528
109PRKD20.42998870
110TAOK20.42348158
111MARK20.41868225
112SRC0.41739104
113PRKG20.41355035
114RPS6KA10.41260348
115IRAK20.41245465
116MOS0.41194587
117CHUK0.40278102
118CSF1R0.39791402
119PRKCH0.39050464
120MAP2K10.36641553
121CLK10.36272937
122CSNK1A1L0.34687173
123MAPK40.34659076
124RPS6KA20.34345460
125MKNK10.34323835
126MAP3K80.32850956
127MAPKAPK20.32524966
128NME20.32176906
129NTRK10.31474668
130AKT20.30645203
131MAPK10.30363125
132DAPK20.30194188
133KSR10.29944094
134STK240.28972910
135NEK20.28565474
136ADRBK10.27578183
137STK100.27264059
138CDK40.26768015
139RPS6KC10.24734890
140RPS6KL10.24734890
141CAMK40.24548055
142MAP3K110.24000678
143MAPK80.23527780
144ERBB30.22268885
145MAPK90.21595611
146AKT10.21554929

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.02936167
2Hedgehog signaling pathway_Homo sapiens_hsa043404.29288720
3ECM-receptor interaction_Homo sapiens_hsa045124.19702806
4Protein digestion and absorption_Homo sapiens_hsa049743.13435628
5Hippo signaling pathway_Homo sapiens_hsa043902.79832761
6Other glycan degradation_Homo sapiens_hsa005112.57970546
7Focal adhesion_Homo sapiens_hsa045102.54599815
8Notch signaling pathway_Homo sapiens_hsa043302.51496791
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.29465862
10Proteoglycans in cancer_Homo sapiens_hsa052052.24361751
11Small cell lung cancer_Homo sapiens_hsa052222.18955688
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.08652833
13Adherens junction_Homo sapiens_hsa045202.01699468
14Amoebiasis_Homo sapiens_hsa051462.00073259
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99671802
16Melanogenesis_Homo sapiens_hsa049161.96825613
17Wnt signaling pathway_Homo sapiens_hsa043101.90588335
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88403427
19Axon guidance_Homo sapiens_hsa043601.75667651
20Bladder cancer_Homo sapiens_hsa052191.69719834
21Pathways in cancer_Homo sapiens_hsa052001.67878255
22TGF-beta signaling pathway_Homo sapiens_hsa043501.59368566
23MicroRNAs in cancer_Homo sapiens_hsa052061.56175011
24Dilated cardiomyopathy_Homo sapiens_hsa054141.48223363
25Chronic myeloid leukemia_Homo sapiens_hsa052201.43267751
26Osteoclast differentiation_Homo sapiens_hsa043801.39537868
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38680778
28Tight junction_Homo sapiens_hsa045301.33701589
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31967901
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31891657
31Endometrial cancer_Homo sapiens_hsa052131.27535242
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23910235
33HTLV-I infection_Homo sapiens_hsa051661.20633042
34Colorectal cancer_Homo sapiens_hsa052101.19825385
35Renal cell carcinoma_Homo sapiens_hsa052111.19205430
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15416224
37Prostate cancer_Homo sapiens_hsa052151.14366721
38Melanoma_Homo sapiens_hsa052181.13647218
39Toxoplasmosis_Homo sapiens_hsa051451.11453643
40Rap1 signaling pathway_Homo sapiens_hsa040151.10302528
41Glioma_Homo sapiens_hsa052141.09728637
42Estrogen signaling pathway_Homo sapiens_hsa049151.08207409
43B cell receptor signaling pathway_Homo sapiens_hsa046621.01815507
44Viral myocarditis_Homo sapiens_hsa054161.00754542
45Thyroid cancer_Homo sapiens_hsa052161.00325349
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.96861370
47Leishmaniasis_Homo sapiens_hsa051400.95732202
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.95029603
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93571919
50VEGF signaling pathway_Homo sapiens_hsa043700.93093027
51Lysosome_Homo sapiens_hsa041420.92737872
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92712333
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92254997
54Pancreatic cancer_Homo sapiens_hsa052120.92250274
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92171236
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91152697
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83935883
58Hepatitis C_Homo sapiens_hsa051600.82270694
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.80905069
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80511190
61Pertussis_Homo sapiens_hsa051330.80487654
62Inositol phosphate metabolism_Homo sapiens_hsa005620.80192880
63Non-small cell lung cancer_Homo sapiens_hsa052230.80043996
64Insulin resistance_Homo sapiens_hsa049310.78681022
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75642612
66Dorso-ventral axis formation_Homo sapiens_hsa043200.75080777
67Platelet activation_Homo sapiens_hsa046110.74412430
68ErbB signaling pathway_Homo sapiens_hsa040120.73000283
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72807329
70Gap junction_Homo sapiens_hsa045400.71100719
71Tuberculosis_Homo sapiens_hsa051520.70655414
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70240466
73Influenza A_Homo sapiens_hsa051640.69781109
74Acute myeloid leukemia_Homo sapiens_hsa052210.69626833
75T cell receptor signaling pathway_Homo sapiens_hsa046600.69121654
76Lysine degradation_Homo sapiens_hsa003100.68991943
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.68765257
78Shigellosis_Homo sapiens_hsa051310.67683295
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66419166
80Staphylococcus aureus infection_Homo sapiens_hsa051500.63771084
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63230771
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.62503156
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.61659279
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.61641260
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61317218
86Salmonella infection_Homo sapiens_hsa051320.61008493
87Chemokine signaling pathway_Homo sapiens_hsa040620.60859081
88GnRH signaling pathway_Homo sapiens_hsa049120.60811797
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60804824
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60461880
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58538055
92African trypanosomiasis_Homo sapiens_hsa051430.57809173
93mTOR signaling pathway_Homo sapiens_hsa041500.57230330
94Phagosome_Homo sapiens_hsa041450.57089557
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56726002
96Ras signaling pathway_Homo sapiens_hsa040140.55888637
97TNF signaling pathway_Homo sapiens_hsa046680.55833776
98Prion diseases_Homo sapiens_hsa050200.55614880
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52895160
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52729977
101HIF-1 signaling pathway_Homo sapiens_hsa040660.52688366
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.50885787
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50643455
104Insulin signaling pathway_Homo sapiens_hsa049100.47182941
105Prolactin signaling pathway_Homo sapiens_hsa049170.44421499
106MAPK signaling pathway_Homo sapiens_hsa040100.44252188
107Malaria_Homo sapiens_hsa051440.43464592
108Viral carcinogenesis_Homo sapiens_hsa052030.42536583
109AMPK signaling pathway_Homo sapiens_hsa041520.41789123
110Cell cycle_Homo sapiens_hsa041100.41542906
111FoxO signaling pathway_Homo sapiens_hsa040680.39874417
112Endocytosis_Homo sapiens_hsa041440.39469631
113p53 signaling pathway_Homo sapiens_hsa041150.38855831
114Oxytocin signaling pathway_Homo sapiens_hsa049210.38627780
115Cocaine addiction_Homo sapiens_hsa050300.37682038
116Hepatitis B_Homo sapiens_hsa051610.37375295
117cAMP signaling pathway_Homo sapiens_hsa040240.35849981
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.35693683
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35666649
120Apoptosis_Homo sapiens_hsa042100.34319136
121Type II diabetes mellitus_Homo sapiens_hsa049300.33853011
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33093274
123Choline metabolism in cancer_Homo sapiens_hsa052310.32739725
124Gastric acid secretion_Homo sapiens_hsa049710.31754295
125Renin secretion_Homo sapiens_hsa049240.31591240
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29663022
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26366309
128Ribosome_Homo sapiens_hsa030100.25966413
129Thyroid hormone synthesis_Homo sapiens_hsa049180.25845792
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24587780

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