MED7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.04110738
2respiratory chain complex IV assembly (GO:0008535)4.77856231
3proteasome assembly (GO:0043248)4.73083705
4cytochrome complex assembly (GO:0017004)4.67665076
5protein complex biogenesis (GO:0070271)4.65989500
6ribosomal small subunit assembly (GO:0000028)4.57807197
7mitochondrial respiratory chain complex assembly (GO:0033108)4.47504092
8DNA double-strand break processing (GO:0000729)4.46498250
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37615374
10CENP-A containing nucleosome assembly (GO:0034080)4.15536577
11maturation of SSU-rRNA (GO:0030490)4.14303919
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.03176965
13chromatin remodeling at centromere (GO:0031055)4.02729489
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95165477
15mitotic metaphase plate congression (GO:0007080)3.93786412
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.93226115
17NADH dehydrogenase complex assembly (GO:0010257)3.93226115
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93226115
19protein neddylation (GO:0045116)3.90041081
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87983811
21viral transcription (GO:0019083)3.87800419
22formation of translation preinitiation complex (GO:0001731)3.87513677
23translational termination (GO:0006415)3.85483596
24ribosomal small subunit biogenesis (GO:0042274)3.80002611
25termination of RNA polymerase III transcription (GO:0006386)3.79019646
26transcription elongation from RNA polymerase III promoter (GO:0006385)3.79019646
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76423911
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76051176
29DNA strand elongation involved in DNA replication (GO:0006271)3.75551445
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75459234
31water-soluble vitamin biosynthetic process (GO:0042364)3.74510131
32DNA replication checkpoint (GO:0000076)3.72756953
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70143689
34purine nucleobase biosynthetic process (GO:0009113)3.68571567
35telomere maintenance via semi-conservative replication (GO:0032201)3.66464923
36cotranslational protein targeting to membrane (GO:0006613)3.65996444
37DNA replication-independent nucleosome assembly (GO:0006336)3.65660163
38DNA replication-independent nucleosome organization (GO:0034724)3.65660163
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61584399
40regulation of mitotic spindle checkpoint (GO:1903504)3.61584399
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61315080
42ATP synthesis coupled proton transport (GO:0015986)3.61315080
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61044357
44negative regulation of ligase activity (GO:0051352)3.61044357
45protein targeting to ER (GO:0045047)3.60396500
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59728009
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59728009
48nucleobase biosynthetic process (GO:0046112)3.59199271
49DNA strand elongation (GO:0022616)3.58738818
50protein deneddylation (GO:0000338)3.58162730
51ribosomal large subunit biogenesis (GO:0042273)3.57625223
52ribonucleoprotein complex biogenesis (GO:0022613)3.56208305
53DNA replication initiation (GO:0006270)3.55506468
54cullin deneddylation (GO:0010388)3.54140153
55chaperone-mediated protein transport (GO:0072321)3.53282662
56translational elongation (GO:0006414)3.48676736
57pseudouridine synthesis (GO:0001522)3.48560510
58DNA catabolic process, exonucleolytic (GO:0000738)3.48197819
59mannosylation (GO:0097502)3.47836171
60translational initiation (GO:0006413)3.47729722
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47028526
62spliceosomal snRNP assembly (GO:0000387)3.46660838
63ribosome biogenesis (GO:0042254)3.45870709
64protein localization to endoplasmic reticulum (GO:0070972)3.45622612
65respiratory electron transport chain (GO:0022904)3.43391900
66histone exchange (GO:0043486)3.42076779
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39268240
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38833477
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36050887
70electron transport chain (GO:0022900)3.35380882
71metaphase plate congression (GO:0051310)3.35156301
72histone mRNA metabolic process (GO:0008334)3.34855933
73regulation of cellular amino acid metabolic process (GO:0006521)3.34632464
74aldehyde catabolic process (GO:0046185)3.34383106
75ribosome assembly (GO:0042255)3.33639233
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33409195
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33409195
78RNA capping (GO:0036260)3.32457052
797-methylguanosine RNA capping (GO:0009452)3.32457052
807-methylguanosine mRNA capping (GO:0006370)3.31218852
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30847445
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30847445
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30847445
84kinetochore organization (GO:0051383)3.29086799
85DNA damage response, detection of DNA damage (GO:0042769)3.28540687
86telomere maintenance via recombination (GO:0000722)3.27817507
87translation (GO:0006412)3.27745626
88rRNA processing (GO:0006364)3.27502845
89transcription from mitochondrial promoter (GO:0006390)3.26720191
90transcription-coupled nucleotide-excision repair (GO:0006283)3.26482167
91rRNA modification (GO:0000154)3.26475197
92positive regulation of ligase activity (GO:0051351)3.23914589
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23899669
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22445009
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22419981
96establishment of integrated proviral latency (GO:0075713)3.21932947
97kinetochore assembly (GO:0051382)3.19734215
98regulation of mitochondrial translation (GO:0070129)3.19696564
99negative regulation of DNA-dependent DNA replication (GO:2000104)3.19633506
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19571159
101signal transduction involved in DNA damage checkpoint (GO:0072422)3.19571159
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18192220
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16226751
104signal transduction involved in cell cycle checkpoint (GO:0072395)3.15440153
105rRNA metabolic process (GO:0016072)3.14637971
106mitotic recombination (GO:0006312)3.14632461
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14612517
108deoxyribonucleotide biosynthetic process (GO:0009263)3.10931699
109spliceosomal complex assembly (GO:0000245)3.10251482
110attachment of spindle microtubules to kinetochore (GO:0008608)3.09409274
111viral life cycle (GO:0019058)3.07740191
112G1/S transition of mitotic cell cycle (GO:0000082)3.06596813
113cell cycle G1/S phase transition (GO:0044843)3.06596813
114establishment of chromosome localization (GO:0051303)3.05938613
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04565637
116antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03781569
117cellular component biogenesis (GO:0044085)3.02675232
118telomere maintenance via telomere lengthening (GO:0010833)3.02526697
119transcription elongation from RNA polymerase II promoter (GO:0006368)3.02512911
120oxidative phosphorylation (GO:0006119)3.02156994
1212-deoxyribonucleotide biosynthetic process (GO:0009265)3.01468201
122deoxyribose phosphate biosynthetic process (GO:0046385)3.01468201
123cellular protein complex disassembly (GO:0043624)2.99229336
124regulation of ubiquitin-protein transferase activity (GO:0051438)2.98872002
125DNA ligation (GO:0006266)2.98129537
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.97635237
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97635237
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97635237
129protein targeting to mitochondrion (GO:0006626)2.97176394
130protein localization to mitochondrion (GO:0070585)2.96135922
131lactate metabolic process (GO:0006089)2.95824457
132protein localization to kinetochore (GO:0034501)2.95588188
133double-strand break repair via nonhomologous end joining (GO:0006303)2.95524746
134non-recombinational repair (GO:0000726)2.95524746
135maturation of 5.8S rRNA (GO:0000460)2.95463117
136nonmotile primary cilium assembly (GO:0035058)2.94241381
137protein K11-linked ubiquitination (GO:0070979)2.92997836
138regulation of ligase activity (GO:0051340)2.90321319
139synapsis (GO:0007129)2.89857139
140establishment of viral latency (GO:0019043)2.86347830
141termination of RNA polymerase I transcription (GO:0006363)2.86290193
142pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84392251
143protein localization to chromosome, centromeric region (GO:0071459)2.83727770
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82326650
145replication fork processing (GO:0031297)2.81254075
146isotype switching (GO:0045190)2.80709348
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80709348
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80709348
149peptidyl-histidine modification (GO:0018202)2.77685176
150platelet dense granule organization (GO:0060155)2.77625746
151resolution of meiotic recombination intermediates (GO:0000712)2.76730590
152establishment of protein localization to mitochondrion (GO:0072655)2.74406524
153mitochondrial RNA metabolic process (GO:0000959)2.74246558
154protein-cofactor linkage (GO:0018065)2.73131437
155ubiquinone metabolic process (GO:0006743)2.72734408
156intraciliary transport (GO:0042073)2.72223725
157preassembly of GPI anchor in ER membrane (GO:0016254)2.70248083
158protein K6-linked ubiquitination (GO:0085020)2.67387805
159regulation of hexokinase activity (GO:1903299)2.65825733
160regulation of glucokinase activity (GO:0033131)2.65825733
161regulation of helicase activity (GO:0051095)2.65645812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48430304
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23525867
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.17710177
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.02047588
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.69966535
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55163934
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53044971
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25127445
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.24298328
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96490433
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91637532
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91103588
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89181390
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84137041
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80890677
16VDR_23849224_ChIP-Seq_CD4+_Human2.77842240
17ZNF274_21170338_ChIP-Seq_K562_Hela2.68527860
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67160359
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61741474
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60204274
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59329802
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.53684182
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52984626
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46689041
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45754544
26DCP1A_22483619_ChIP-Seq_HELA_Human2.42623254
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41993428
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33669194
29XRN2_22483619_ChIP-Seq_HELA_Human2.33483887
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33466501
31FOXP3_21729870_ChIP-Seq_TREG_Human2.16831294
32ELK1_19687146_ChIP-ChIP_HELA_Human2.13186267
33GABP_19822575_ChIP-Seq_HepG2_Human2.11744934
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10879930
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10719763
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09551150
37EWS_26573619_Chip-Seq_HEK293_Human2.07166703
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05988249
39* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05717195
40SALL1_21062744_ChIP-ChIP_HESCs_Human2.02953123
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.00083522
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95836088
43TTF2_22483619_ChIP-Seq_HELA_Human1.95555711
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92509318
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91119370
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89629806
47TAF15_26573619_Chip-Seq_HEK293_Human1.86846616
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86628249
49FUS_26573619_Chip-Seq_HEK293_Human1.82220645
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81354273
51AR_21909140_ChIP-Seq_LNCAP_Human1.80978531
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76630467
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76498656
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.70481433
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69567855
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65785594
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64091806
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63068981
59VDR_22108803_ChIP-Seq_LS180_Human1.62822194
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.57105566
61P300_19829295_ChIP-Seq_ESCs_Human1.55645015
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54310973
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.52647147
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52537727
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50774934
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50240207
67IGF1R_20145208_ChIP-Seq_DFB_Human1.50130619
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49600791
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46433200
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43738482
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38843078
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35194004
73GBX2_23144817_ChIP-Seq_PC3_Human1.34697170
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33318065
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29910595
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28556372
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.25732290
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24192089
79CIITA_25753668_ChIP-Seq_RAJI_Human1.24026900
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23826514
81ER_23166858_ChIP-Seq_MCF-7_Human1.23803601
82MYC_18940864_ChIP-ChIP_HL60_Human1.22977744
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22557249
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21960766
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20643321
86KDM5A_27292631_Chip-Seq_BREAST_Human1.20214461
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19524760
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19420527
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17388192
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.16807151
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16398732
92TFEB_21752829_ChIP-Seq_HELA_Human1.16367179
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16125074
94TP53_22573176_ChIP-Seq_HFKS_Human1.15736235
95IRF1_19129219_ChIP-ChIP_H3396_Human1.12954774
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12279065
97* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12242230
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12006594
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11303030
100CBP_20019798_ChIP-Seq_JUKART_Human1.11303030
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10701953
102* SPI1_23547873_ChIP-Seq_NB4_Human1.10005440
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09316624
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08766882
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08040810
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.06280378
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05642858
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05176545
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05017148
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04988708
111NANOG_19829295_ChIP-Seq_ESCs_Human1.03470815
112SOX2_19829295_ChIP-Seq_ESCs_Human1.03470815
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01900022
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01140307
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.01140307
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00988613
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99140250
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97924260
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97828495
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97350540
121* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96776909
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94731890
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.93579110
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.93146769
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92490461
126FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90403950
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.90351971
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.89405604
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.88990708
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88568729
131AR_20517297_ChIP-Seq_VCAP_Human0.88081234
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87855668
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87347261
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86310300
135* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86276996
136FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85765940
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83525880
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83446861
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.79072944
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78394139
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77171255
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75353370
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74439197
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72656004
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72565383
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71978302
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71452218
148TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69886641
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69660251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.68690467
2MP0004957_abnormal_blastocyst_morpholog4.08790739
3MP0010094_abnormal_chromosome_stability3.99443684
4MP0003111_abnormal_nucleus_morphology3.81164338
5MP0003077_abnormal_cell_cycle3.57114000
6MP0008057_abnormal_DNA_replication3.51853004
7MP0008058_abnormal_DNA_repair3.43048051
8MP0006072_abnormal_retinal_apoptosis3.26904888
9MP0008007_abnormal_cellular_replicative3.12249894
10MP0008932_abnormal_embryonic_tissue2.72551593
11MP0006292_abnormal_olfactory_placode2.70652805
12MP0003786_premature_aging2.58172740
13MP0002396_abnormal_hematopoietic_system2.43924957
14MP0003806_abnormal_nucleotide_metabolis2.33555944
15MP0001984_abnormal_olfaction2.32757795
16MP0002138_abnormal_hepatobiliary_system2.31762735
17MP0003718_maternal_effect2.28728005
18MP0005084_abnormal_gallbladder_morpholo2.12858160
19MP0008877_abnormal_DNA_methylation2.11163834
20MP0002163_abnormal_gland_morphology2.00167275
21MP0005253_abnormal_eye_physiology1.98267084
22MP0008875_abnormal_xenobiotic_pharmacok1.96475328
23MP0009333_abnormal_splenocyte_physiolog1.92950759
24MP0003787_abnormal_imprinting1.86637164
25MP0001730_embryonic_growth_arrest1.77254841
26MP0000490_abnormal_crypts_of1.73640767
27MP0006054_spinal_hemorrhage1.73571238
28MP0000350_abnormal_cell_proliferation1.69278138
29MP0003011_delayed_dark_adaptation1.65366663
30MP0002210_abnormal_sex_determination1.62276222
31MP0003186_abnormal_redox_activity1.60970136
32MP0003123_paternal_imprinting1.60825150
33MP0002837_dystrophic_cardiac_calcinosis1.59178514
34MP0003195_calcinosis1.56070906
35MP0004147_increased_porphyrin_level1.54343503
36MP0006036_abnormal_mitochondrial_physio1.53922290
37MP0009697_abnormal_copulation1.53815102
38MP0005394_taste/olfaction_phenotype1.52229390
39MP0005499_abnormal_olfactory_system1.52229390
40MP0001986_abnormal_taste_sensitivity1.50675505
41MP0001929_abnormal_gametogenesis1.48621098
42MP0005379_endocrine/exocrine_gland_phen1.47956832
43MP0003315_abnormal_perineum_morphology1.44608324
44MP0002736_abnormal_nociception_after1.42546799
45MP0005551_abnormal_eye_electrophysiolog1.42422532
46MP0009780_abnormal_chondrocyte_physiolo1.40657568
47MP0009379_abnormal_foot_pigmentation1.40549789
48MP0003656_abnormal_erythrocyte_physiolo1.39095378
49MP0001145_abnormal_male_reproductive1.36431190
50MP0004215_abnormal_myocardial_fiber1.34242845
51MP0002751_abnormal_autonomic_nervous1.34222918
52MP0000647_abnormal_sebaceous_gland1.32858616
53MP0009046_muscle_twitch1.32751387
54MP0008872_abnormal_physiological_respon1.32307720
55MP0001545_abnormal_hematopoietic_system1.31391025
56MP0005397_hematopoietic_system_phenotyp1.31391025
57MP0001764_abnormal_homeostasis1.31378229
58MP0000313_abnormal_cell_death1.30717856
59MP0002019_abnormal_tumor_incidence1.29373478
60MP0004808_abnormal_hematopoietic_stem1.29305881
61MP0002139_abnormal_hepatobiliary_system1.29153346
62MP0000653_abnormal_sex_gland1.28910524
63MP0001697_abnormal_embryo_size1.27504307
64MP0005645_abnormal_hypothalamus_physiol1.25703310
65MP0000465_gastrointestinal_hemorrhage1.23994042
66MP0005671_abnormal_response_to1.22301677
67MP0004142_abnormal_muscle_tone1.21447270
68MP0001968_abnormal_touch/_nociception1.20724314
69MP0002080_prenatal_lethality1.20069035
70MP0002398_abnormal_bone_marrow1.19249782
71MP0003763_abnormal_thymus_physiology1.18550892
72MP0003880_abnormal_central_pattern1.16371959
73MP0005389_reproductive_system_phenotype1.14368590
74MP0002160_abnormal_reproductive_system1.14130173
75MP0001119_abnormal_female_reproductive1.13933926
76MP0000689_abnormal_spleen_morphology1.13608269
77MP0002653_abnormal_ependyma_morphology1.12144733
78MP0001835_abnormal_antigen_presentation1.11355789
79MP0005380_embryogenesis_phenotype1.09127449
80MP0001672_abnormal_embryogenesis/_devel1.09127449
81MP0003941_abnormal_skin_development1.07169912
82MP0002722_abnormal_immune_system1.06381262
83MP0006035_abnormal_mitochondrial_morpho1.03970905
84MP0003221_abnormal_cardiomyocyte_apopto1.03431352
85MP0000358_abnormal_cell_content/1.02951777
86MP0001919_abnormal_reproductive_system1.02661455
87MP0006276_abnormal_autonomic_nervous0.98471062
88MP0000569_abnormal_digit_pigmentation0.98117512
89MP0003984_embryonic_growth_retardation0.97164871
90MP0005220_abnormal_exocrine_pancreas0.96768643
91MP0002090_abnormal_vision0.96703524
92MP0008260_abnormal_autophagy0.96692659
93MP0002938_white_spotting0.96541037
94MP0002928_abnormal_bile_duct0.96520771
95MP0005075_abnormal_melanosome_morpholog0.95181114
96MP0009785_altered_susceptibility_to0.94771213
97MP0002132_abnormal_respiratory_system0.94663773
98MP0008789_abnormal_olfactory_epithelium0.94627343
99MP0002095_abnormal_skin_pigmentation0.94563386
100MP0002429_abnormal_blood_cell0.94499650
101MP0003567_abnormal_fetal_cardiomyocyte0.93452372
102MP0002102_abnormal_ear_morphology0.93039152
103MP0002088_abnormal_embryonic_growth/wei0.91584194
104MP0001293_anophthalmia0.91491058
105MP0002085_abnormal_embryonic_tissue0.91265064
106MP0005367_renal/urinary_system_phenotyp0.90767571
107MP0000516_abnormal_urinary_system0.90767571
108MP0009745_abnormal_behavioral_response0.90540687
109MP0002638_abnormal_pupillary_reflex0.90457525
110MP0001529_abnormal_vocalization0.89437522
111MP0005410_abnormal_fertilization0.86274527
112MP0000716_abnormal_immune_system0.85428599
113MP0000703_abnormal_thymus_morphology0.84896380
114MP0000427_abnormal_hair_cycle0.84407775
115MP0005408_hypopigmentation0.83538454
116MP0005085_abnormal_gallbladder_physiolo0.82606275
117MP0005332_abnormal_amino_acid0.80357237
118MP0001324_abnormal_eye_pigmentation0.80250848
119MP0002254_reproductive_system_inflammat0.80158504
120MP0002084_abnormal_developmental_patter0.79635431
121MP0000631_abnormal_neuroendocrine_gland0.79585937
122MP0002420_abnormal_adaptive_immunity0.78955174
123MP0001905_abnormal_dopamine_level0.78732901
124MP0003698_abnormal_male_reproductive0.78327419
125MP0005646_abnormal_pituitary_gland0.77675258
126MP0002723_abnormal_immune_serum0.77450750
127MP0003122_maternal_imprinting0.77388428
128MP0002452_abnormal_antigen_presenting0.77298759
129MP0003890_abnormal_embryonic-extraembry0.77107395
130MP0001819_abnormal_immune_cell0.76897517
131MP0005187_abnormal_penis_morphology0.76407287
132MP0001188_hyperpigmentation0.75869371
133MP0001853_heart_inflammation0.74837610
134MP0003436_decreased_susceptibility_to0.74576518
135MP0002272_abnormal_nervous_system0.73691489
136MP0003943_abnormal_hepatobiliary_system0.73527468
137MP0010386_abnormal_urinary_bladder0.73077770
138MP0001800_abnormal_humoral_immune0.72933427
139MP0000858_altered_metastatic_potential0.72902020
140MP0005391_vision/eye_phenotype0.72497865
141MP0003252_abnormal_bile_duct0.72041218
142MP0005000_abnormal_immune_tolerance0.71840145
143MP0002086_abnormal_extraembryonic_tissu0.71707674
144MP0003121_genomic_imprinting0.71524444
145MP0005386_behavior/neurological_phenoty0.71419529
146MP0004924_abnormal_behavior0.71419529
147MP0005384_cellular_phenotype0.68876612
148MP0005395_other_phenotype0.68815942
149MP0008873_increased_physiological_sensi0.67817758
150MP0000372_irregular_coat_pigmentation0.67040541
151MP0004197_abnormal_fetal_growth/weight/0.64589670
152MP0001542_abnormal_bone_strength0.63355637
153MP0000685_abnormal_immune_system0.62866637
154MP0004133_heterotaxia0.62716503
155MP0002148_abnormal_hypersensitivity_rea0.61282070
156MP0002161_abnormal_fertility/fecundity0.60777679
157MP0002277_abnormal_respiratory_mucosa0.59200235

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.38568070
2Abnormality of cells of the erythroid lineage (HP:0012130)5.25171712
3Abnormal number of erythroid precursors (HP:0012131)5.20128343
4Breast hypoplasia (HP:0003187)3.98067389
5Reticulocytopenia (HP:0001896)3.95899106
6Aplastic anemia (HP:0001915)3.94890553
7Carpal bone hypoplasia (HP:0001498)3.60243048
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40076133
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40076133
10Type I transferrin isoform profile (HP:0003642)3.28729812
11Oral leukoplakia (HP:0002745)3.23304422
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.20350117
13Hepatocellular necrosis (HP:0001404)3.17532313
14Macrocytic anemia (HP:0001972)3.14708439
15Increased hepatocellular lipid droplets (HP:0006565)3.13514616
16Rough bone trabeculation (HP:0100670)3.11800091
17Medial flaring of the eyebrow (HP:0010747)3.11070576
18Acute necrotizing encephalopathy (HP:0006965)3.01052677
19Mitochondrial inheritance (HP:0001427)2.98595921
20Patellar aplasia (HP:0006443)2.97659128
21Pallor (HP:0000980)2.96455986
22Abnormality of the anterior horn cell (HP:0006802)2.93339939
23Degeneration of anterior horn cells (HP:0002398)2.93339939
24Abnormality of midbrain morphology (HP:0002418)2.90697746
25Molar tooth sign on MRI (HP:0002419)2.90697746
26Microretrognathia (HP:0000308)2.90187532
273-Methylglutaconic aciduria (HP:0003535)2.89692626
28Lipid accumulation in hepatocytes (HP:0006561)2.88200042
29Cerebral edema (HP:0002181)2.85010854
30Irregular epiphyses (HP:0010582)2.80212963
31Aplasia/Hypoplasia of the patella (HP:0006498)2.77577434
32Increased CSF lactate (HP:0002490)2.77549625
33Abnormal mitochondria in muscle tissue (HP:0008316)2.72094403
34Hepatic necrosis (HP:0002605)2.71971516
35Nephrogenic diabetes insipidus (HP:0009806)2.69737771
36Abnormal protein glycosylation (HP:0012346)2.69144830
37Abnormal glycosylation (HP:0012345)2.69144830
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69144830
39Abnormal protein N-linked glycosylation (HP:0012347)2.69144830
40Exertional dyspnea (HP:0002875)2.67579300
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66629367
42Cerebral hypomyelination (HP:0006808)2.62798026
43Abnormality of alanine metabolism (HP:0010916)2.62683285
44Hyperalaninemia (HP:0003348)2.62683285
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62683285
46Poor head control (HP:0002421)2.59864184
47Increased serum lactate (HP:0002151)2.59478218
48Congenital primary aphakia (HP:0007707)2.59310558
4911 pairs of ribs (HP:0000878)2.57149222
50Volvulus (HP:0002580)2.55218423
51Methylmalonic acidemia (HP:0002912)2.54465845
52Gait imbalance (HP:0002141)2.53864247
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52761292
54Reduced antithrombin III activity (HP:0001976)2.52198774
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52184815
56Respiratory failure (HP:0002878)2.42163555
57Nephronophthisis (HP:0000090)2.41700363
58Microvesicular hepatic steatosis (HP:0001414)2.39783596
59Abnormal trabecular bone morphology (HP:0100671)2.38472570
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36908370
61Supernumerary spleens (HP:0009799)2.36514632
62Acute encephalopathy (HP:0006846)2.35149227
63Renal Fanconi syndrome (HP:0001994)2.33976855
64Secondary amenorrhea (HP:0000869)2.32098486
65Abnormality of the labia minora (HP:0012880)2.31446763
66Premature ovarian failure (HP:0008209)2.31341987
67Pancreatic cysts (HP:0001737)2.31329914
68Methylmalonic aciduria (HP:0012120)2.31221933
69Premature graying of hair (HP:0002216)2.27911512
70Abnormal spermatogenesis (HP:0008669)2.23485403
71Hypothermia (HP:0002045)2.23419642
72Pancytopenia (HP:0001876)2.22029292
73Abnormal lung lobation (HP:0002101)2.21040623
74Bone marrow hypocellularity (HP:0005528)2.20522780
75Increased intramyocellular lipid droplets (HP:0012240)2.19014073
76Neoplasm of the adrenal gland (HP:0100631)2.18948262
77Optic disc pallor (HP:0000543)2.16990412
78Progressive macrocephaly (HP:0004481)2.16827542
79Lethargy (HP:0001254)2.13252860
80Increased serum pyruvate (HP:0003542)2.13027011
81Glycosuria (HP:0003076)2.12936737
82Abnormality of urine glucose concentration (HP:0011016)2.12936737
83Genital tract atresia (HP:0001827)2.12655231
84Respiratory difficulties (HP:0002880)2.11708758
85Pancreatic islet-cell hyperplasia (HP:0004510)2.11223780
86Myelodysplasia (HP:0002863)2.06993339
87CNS demyelination (HP:0007305)2.06969407
88Glossoptosis (HP:0000162)2.04816787
89Postnatal microcephaly (HP:0005484)2.04716894
90Vaginal atresia (HP:0000148)2.03655687
91Meckel diverticulum (HP:0002245)2.03110483
92Abnormality of the preputium (HP:0100587)2.02446991
93Rimmed vacuoles (HP:0003805)2.02406699
94Abnormality of chromosome stability (HP:0003220)2.01468203
95Sparse eyelashes (HP:0000653)2.01268484
96Abnormality of the renal medulla (HP:0100957)2.01232203
97Stenosis of the external auditory canal (HP:0000402)2.01226733
98Cleft eyelid (HP:0000625)2.00637937
99Hypoplasia of the uterus (HP:0000013)2.00407334
100Trismus (HP:0000211)1.99512564
101True hermaphroditism (HP:0010459)1.99032515
102Absent thumb (HP:0009777)1.98257740
103Hyperglycinemia (HP:0002154)1.97694464
104Selective tooth agenesis (HP:0001592)1.96951741
105Chromsome breakage (HP:0040012)1.96865387
106Pancreatic fibrosis (HP:0100732)1.95192626
107Absent radius (HP:0003974)1.93641055
108Thrombocytosis (HP:0001894)1.93236211
109Flat capital femoral epiphysis (HP:0003370)1.93021873
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.92954920
111Abnormality of renal resorption (HP:0011038)1.92872086
112Lactic acidosis (HP:0003128)1.92125922
113IgM deficiency (HP:0002850)1.88964582
114Abnormality of the ileum (HP:0001549)1.88642927
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.86892006
116Sclerocornea (HP:0000647)1.86580494
117Bile duct proliferation (HP:0001408)1.84814730
118Abnormal biliary tract physiology (HP:0012439)1.84814730
119Triphalangeal thumb (HP:0001199)1.83890740
120Exercise intolerance (HP:0003546)1.83344876
121Capillary hemangiomas (HP:0005306)1.83198866
122Colon cancer (HP:0003003)1.82794114
123Sloping forehead (HP:0000340)1.80906145
124Congenital, generalized hypertrichosis (HP:0004540)1.80048939
125Leukodystrophy (HP:0002415)1.79076163
126Posterior subcapsular cataract (HP:0007787)1.78424240
127Increased muscle lipid content (HP:0009058)1.77744208
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77356955
129Aplasia/hypoplasia of the uterus (HP:0008684)1.76174199
130Type 2 muscle fiber atrophy (HP:0003554)1.75727451
131Small intestinal stenosis (HP:0012848)1.75429539
132Duodenal stenosis (HP:0100867)1.75429539
133Aplasia involving forearm bones (HP:0009822)1.75086482
134Absent forearm bone (HP:0003953)1.75086482
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74955205
136Cellular immunodeficiency (HP:0005374)1.74620778
137Oligodactyly (hands) (HP:0001180)1.73757215
138Intestinal atresia (HP:0011100)1.73626534
139Abnormality of the renal cortex (HP:0011035)1.71724417
140Hyperinsulinemic hypoglycemia (HP:0000825)1.68989259
141Abnormality of glycolysis (HP:0004366)1.68587988
142Hyperphosphaturia (HP:0003109)1.67839648
143Abnormality of serum amino acid levels (HP:0003112)1.67688884
144Lissencephaly (HP:0001339)1.66144752
145Attenuation of retinal blood vessels (HP:0007843)1.64999598
146Bifid tongue (HP:0010297)1.64605374
147Abolished electroretinogram (ERG) (HP:0000550)1.64252827
148Specific learning disability (HP:0001328)1.63756363
149Furrowed tongue (HP:0000221)1.63649181
150Muscular hypotonia of the trunk (HP:0008936)1.62804081
151Renal cortical cysts (HP:0000803)1.61385406
152Postaxial foot polydactyly (HP:0001830)1.60985371
153Hypoglycemic coma (HP:0001325)1.60929062
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59937762
155Abnormality of lateral ventricle (HP:0030047)1.59586924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.54568708
2WEE13.91887220
3EIF2AK13.75277990
4STK163.33419166
5EIF2AK33.10587166
6NME22.93213432
7FRK2.78994613
8TRIM282.74425791
9ACVR1B2.66230706
10DYRK32.59677958
11SRPK12.58367748
12CDC72.52922162
13BRSK22.45264472
14PLK42.43361926
15VRK12.37188787
16BCKDK2.14547549
17VRK22.03245196
18BCR1.98526890
19WNK31.93123380
20MAP4K21.85396212
21RPS6KA41.84509589
22PBK1.81815533
23PIM21.76466682
24NEK21.68521716
25ERBB31.66781664
26TESK21.63294971
27PLK11.57324554
28MKNK11.53655979
29CCNB11.50891181
30PNCK1.48982507
31DYRK21.48349668
32TTK1.38815516
33GRK11.37453274
34AURKB1.32029033
35PASK1.30440054
36MST41.29737896
37CSNK1G21.27446654
38MAP3K41.26651521
39PLK21.26298830
40KDR1.22769610
41CHEK21.19443135
42BRSK11.19402371
43AURKA1.18590387
44TLK11.17650109
45BRAF1.15938709
46CDK71.15469751
47MAP3K121.12563061
48CASK1.08886185
49ATR1.07274070
50NLK1.07049571
51PLK31.04073200
52MAP2K71.03222854
53SCYL21.01167766
54TAF11.00320711
55TNIK0.99565013
56RPS6KB20.98399155
57CSNK1A1L0.98262770
58MKNK20.97533419
59PINK10.96916707
60FLT30.95698980
61MAP4K10.94574987
62MAP3K110.92679303
63OXSR10.90206347
64IRAK40.89893685
65TGFBR10.87651137
66STK38L0.83964936
67EIF2AK20.83951888
68TSSK60.83125438
69STK390.80938949
70MAPK130.79522490
71RPS6KA50.79158118
72MAPKAPK50.77906735
73CDK80.77409947
74MAP3K80.76514889
75STK100.75059322
76ADRBK20.74810857
77TESK10.74742709
78TEC0.74113197
79CDK190.73636087
80PAK40.71699775
81CSNK2A10.70062258
82PRKCE0.69623361
83ZAK0.69147156
84MAPKAPK30.68882764
85ZAP700.68210574
86NEK10.66194441
87INSRR0.65421490
88KIT0.64277620
89LIMK10.64191737
90YES10.62606214
91CHEK10.62530075
92NME10.62250818
93STK40.60893128
94TXK0.60311184
95PRKCG0.59633575
96MAP3K60.58717244
97EPHA20.58620644
98FGFR20.58093949
99GRK70.57183014
100PHKG20.57021675
101PHKG10.57021675
102MINK10.56632951
103OBSCN0.56599790
104TBK10.56247006
105PIM10.55023992
106CSNK2A20.54156507
107EPHA30.53204901
108ABL20.53119019
109NUAK10.53097685
110ARAF0.52631948
111PIK3CG0.52037209
112IKBKB0.50584275
113PAK30.49746063
114PAK10.48271350
115MOS0.48081511
116ATM0.47927533
117CDK40.47457044
118MAP2K30.47014884
119CSNK1G30.46851602
120BMPR1B0.46355936
121BMPR20.46089486
122IKBKE0.44844788
123CDK90.44028935
124MAP3K30.44011805
125CLK10.43295535
126STK30.43130391
127IRAK10.42513297
128MUSK0.41429319
129LRRK20.40838999
130CSNK1A10.40632366
131TIE10.40211977
132CDK20.37493303
133PDK40.37293202
134PDK30.37293202
135PDK20.35181440
136BLK0.35067803
137WNK40.34833285
138BTK0.34456767
139STK240.33934660
140PKN10.33570197
141MARK10.33565065
142CSNK1G10.33501137
143TAOK30.33443925
144PIK3CA0.33400281
145CSF1R0.32563578
146LYN0.31832574
147CSNK1E0.29435097
148CDK10.29219233
149CAMK2A0.28934357

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36763754
2RNA polymerase_Homo sapiens_hsa030204.05767207
3Ribosome_Homo sapiens_hsa030104.03656357
4DNA replication_Homo sapiens_hsa030303.95765479
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41559616
6Mismatch repair_Homo sapiens_hsa034303.23345638
7Spliceosome_Homo sapiens_hsa030402.89993685
8Homologous recombination_Homo sapiens_hsa034402.88820993
9Protein export_Homo sapiens_hsa030602.88722669
10Caffeine metabolism_Homo sapiens_hsa002322.85716387
11Pyrimidine metabolism_Homo sapiens_hsa002402.81116126
12RNA transport_Homo sapiens_hsa030132.64856236
13Nucleotide excision repair_Homo sapiens_hsa034202.63211758
14Base excision repair_Homo sapiens_hsa034102.41301114
15Basal transcription factors_Homo sapiens_hsa030222.40468099
16Cell cycle_Homo sapiens_hsa041102.21475489
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20552575
18Propanoate metabolism_Homo sapiens_hsa006402.02430310
19RNA degradation_Homo sapiens_hsa030181.94926059
20Fanconi anemia pathway_Homo sapiens_hsa034601.90588299
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81914994
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76514575
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64217952
24Non-homologous end-joining_Homo sapiens_hsa034501.61382762
25One carbon pool by folate_Homo sapiens_hsa006701.55795530
26Fatty acid elongation_Homo sapiens_hsa000621.55786186
27Purine metabolism_Homo sapiens_hsa002301.55617895
28Oxidative phosphorylation_Homo sapiens_hsa001901.53802115
29Folate biosynthesis_Homo sapiens_hsa007901.51413416
30Parkinsons disease_Homo sapiens_hsa050121.48330233
31p53 signaling pathway_Homo sapiens_hsa041151.43103311
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43010115
33Huntingtons disease_Homo sapiens_hsa050161.40344095
34Epstein-Barr virus infection_Homo sapiens_hsa051691.26209313
35mRNA surveillance pathway_Homo sapiens_hsa030151.23238321
36Butanoate metabolism_Homo sapiens_hsa006501.21552895
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12503015
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10778939
39Tryptophan metabolism_Homo sapiens_hsa003801.09568675
40Cardiac muscle contraction_Homo sapiens_hsa042601.05914999
41Peroxisome_Homo sapiens_hsa041461.05769155
42Phototransduction_Homo sapiens_hsa047441.04700206
43Collecting duct acid secretion_Homo sapiens_hsa049661.03129264
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98837811
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96565452
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96493128
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.96266281
48Sulfur metabolism_Homo sapiens_hsa009200.94753197
49Fatty acid metabolism_Homo sapiens_hsa012120.94059229
50Nitrogen metabolism_Homo sapiens_hsa009100.91056807
51Herpes simplex infection_Homo sapiens_hsa051680.91019298
52Legionellosis_Homo sapiens_hsa051340.89186013
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88901805
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86012692
55Pyruvate metabolism_Homo sapiens_hsa006200.85281202
56Antigen processing and presentation_Homo sapiens_hsa046120.85267428
57Fatty acid degradation_Homo sapiens_hsa000710.85170242
58Regulation of autophagy_Homo sapiens_hsa041400.85015241
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84680759
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84358148
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82269902
62Pentose phosphate pathway_Homo sapiens_hsa000300.82120440
63Systemic lupus erythematosus_Homo sapiens_hsa053220.80438162
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.79630233
65Vitamin B6 metabolism_Homo sapiens_hsa007500.76945107
66Alzheimers disease_Homo sapiens_hsa050100.75616668
67Glutathione metabolism_Homo sapiens_hsa004800.75406239
68Sulfur relay system_Homo sapiens_hsa041220.73279980
69Oocyte meiosis_Homo sapiens_hsa041140.68513181
70Chemical carcinogenesis_Homo sapiens_hsa052040.64384267
71N-Glycan biosynthesis_Homo sapiens_hsa005100.64357200
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63380447
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63379123
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61434766
75Viral carcinogenesis_Homo sapiens_hsa052030.58925730
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.58663229
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55516155
78Arachidonic acid metabolism_Homo sapiens_hsa005900.53229182
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53023501
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52954461
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52901087
82Selenocompound metabolism_Homo sapiens_hsa004500.51986851
83Shigellosis_Homo sapiens_hsa051310.51224598
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51125567
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49659486
86Carbon metabolism_Homo sapiens_hsa012000.49010463
87Metabolic pathways_Homo sapiens_hsa011000.48991522
88Nicotine addiction_Homo sapiens_hsa050330.45968249
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45118526
90Circadian rhythm_Homo sapiens_hsa047100.44867224
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44002329
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43618854
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42740198
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40644752
95Measles_Homo sapiens_hsa051620.40403873
96beta-Alanine metabolism_Homo sapiens_hsa004100.39783872
97Primary immunodeficiency_Homo sapiens_hsa053400.39478815
98Thyroid cancer_Homo sapiens_hsa052160.38977209
99Hematopoietic cell lineage_Homo sapiens_hsa046400.38283004
100HTLV-I infection_Homo sapiens_hsa051660.37631493
101Type I diabetes mellitus_Homo sapiens_hsa049400.35306275
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.33638268
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33488083
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.33210313
105Malaria_Homo sapiens_hsa051440.32114596
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.31676555
107Retinol metabolism_Homo sapiens_hsa008300.31346926
108TGF-beta signaling pathway_Homo sapiens_hsa043500.30243922
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29862078
110Sphingolipid metabolism_Homo sapiens_hsa006000.29581864
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29000306
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28413809
113Allograft rejection_Homo sapiens_hsa053300.28082574
114Linoleic acid metabolism_Homo sapiens_hsa005910.27365575
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26843990
116Apoptosis_Homo sapiens_hsa042100.25986054
117Hepatitis B_Homo sapiens_hsa051610.25214137
118Graft-versus-host disease_Homo sapiens_hsa053320.24808739
119Alcoholism_Homo sapiens_hsa050340.24702008
120Mineral absorption_Homo sapiens_hsa049780.24115282
121Ether lipid metabolism_Homo sapiens_hsa005650.24006803
122Influenza A_Homo sapiens_hsa051640.23357968
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23069258
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22975605
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21818054
126Other glycan degradation_Homo sapiens_hsa005110.20820804
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.20782490
128Biosynthesis of amino acids_Homo sapiens_hsa012300.18147601
129Leishmaniasis_Homo sapiens_hsa051400.16923332
130Steroid biosynthesis_Homo sapiens_hsa001000.16912476
131Pertussis_Homo sapiens_hsa051330.16872535
132Asthma_Homo sapiens_hsa053100.16657300
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14678914
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13212138
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.13121825
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09819138
137Arginine and proline metabolism_Homo sapiens_hsa003300.08629975
138Autoimmune thyroid disease_Homo sapiens_hsa053200.08363854
139Vibrio cholerae infection_Homo sapiens_hsa051100.07978903
140Rheumatoid arthritis_Homo sapiens_hsa053230.07113322
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06281610

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