MED6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.99706310
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.45550935
3purine nucleobase biosynthetic process (GO:0009113)4.40831710
4proteasome assembly (GO:0043248)4.33052777
5rRNA modification (GO:0000154)4.32989687
6termination of RNA polymerase III transcription (GO:0006386)4.32752209
7transcription elongation from RNA polymerase III promoter (GO:0006385)4.32752209
8DNA double-strand break processing (GO:0000729)4.27019582
9CENP-A containing nucleosome assembly (GO:0034080)4.20014023
10maturation of SSU-rRNA (GO:0030490)4.18656635
11chaperone-mediated protein transport (GO:0072321)4.15567045
12anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.13860526
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10505024
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.09881668
15metaphase plate congression (GO:0051310)4.09563934
16nucleobase biosynthetic process (GO:0046112)4.07761732
177-methylguanosine mRNA capping (GO:0006370)4.07456978
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.07444556
197-methylguanosine RNA capping (GO:0009452)4.03604400
20RNA capping (GO:0036260)4.03604400
21chromatin remodeling at centromere (GO:0031055)4.01507631
22DNA replication checkpoint (GO:0000076)4.00889044
23ribosome assembly (GO:0042255)3.99503407
24kinetochore organization (GO:0051383)3.96360584
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94957069
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.90723253
27transcription elongation from RNA polymerase I promoter (GO:0006362)3.90030119
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88728804
29kinetochore assembly (GO:0051382)3.88476814
30termination of RNA polymerase I transcription (GO:0006363)3.86029834
31rRNA methylation (GO:0031167)3.76023177
32ribosome biogenesis (GO:0042254)3.74680005
33transcription from RNA polymerase I promoter (GO:0006360)3.74247020
34formation of translation preinitiation complex (GO:0001731)3.72426160
35regulation of spindle organization (GO:0090224)3.72124406
36cullin deneddylation (GO:0010388)3.68632137
37negative regulation of ligase activity (GO:0051352)3.68332636
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68332636
39transcription-coupled nucleotide-excision repair (GO:0006283)3.68155104
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66749609
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.66749609
42NADH dehydrogenase complex assembly (GO:0010257)3.66749609
43protein complex biogenesis (GO:0070271)3.66158011
44protein deneddylation (GO:0000338)3.65548660
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65508264
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65508264
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63733442
48establishment of chromosome localization (GO:0051303)3.63438834
49ribosomal large subunit biogenesis (GO:0042273)3.63275683
50ribonucleoprotein complex biogenesis (GO:0022613)3.61773330
51DNA replication-independent nucleosome assembly (GO:0006336)3.60238110
52DNA replication-independent nucleosome organization (GO:0034724)3.60238110
53respiratory chain complex IV assembly (GO:0008535)3.59406424
54spindle checkpoint (GO:0031577)3.57548304
55mitochondrial respiratory chain complex assembly (GO:0033108)3.57448505
56attachment of spindle microtubules to kinetochore (GO:0008608)3.53016765
57ATP synthesis coupled proton transport (GO:0015986)3.52999153
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52999153
59DNA replication initiation (GO:0006270)3.49965366
60transcription initiation from RNA polymerase I promoter (GO:0006361)3.49733460
61spliceosomal snRNP assembly (GO:0000387)3.49672271
62maturation of 5.8S rRNA (GO:0000460)3.48501485
63histone exchange (GO:0043486)3.47173419
64replication fork processing (GO:0031297)3.45357994
65DNA strand elongation involved in DNA replication (GO:0006271)3.45135097
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42733131
67transcription elongation from RNA polymerase II promoter (GO:0006368)3.41876615
68peptidyl-histidine modification (GO:0018202)3.40553167
69positive regulation of ligase activity (GO:0051351)3.40547143
70rRNA processing (GO:0006364)3.40001318
71protein neddylation (GO:0045116)3.39693045
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39210203
73spliceosomal complex assembly (GO:0000245)3.37702398
74regulation of helicase activity (GO:0051095)3.36048617
75mitotic spindle checkpoint (GO:0071174)3.35946591
76telomere maintenance via semi-conservative replication (GO:0032201)3.34485088
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34185970
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34185970
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34185970
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34005859
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34005859
82ribosomal small subunit biogenesis (GO:0042274)3.33180668
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32743642
84water-soluble vitamin biosynthetic process (GO:0042364)3.32192090
85ribosomal small subunit assembly (GO:0000028)3.30450761
86telomere maintenance via recombination (GO:0000722)3.30174824
87rRNA metabolic process (GO:0016072)3.30081442
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28763721
89negative regulation of sister chromatid segregation (GO:0033046)3.28763721
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.28763721
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28763721
92signal transduction involved in DNA damage checkpoint (GO:0072422)3.27291704
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27291704
94mitotic nuclear envelope disassembly (GO:0007077)3.26957675
95DNA strand elongation (GO:0022616)3.26760428
96regulation of cellular amino acid metabolic process (GO:0006521)3.25730361
97negative regulation of chromosome segregation (GO:0051985)3.24627579
98DNA-templated transcription, elongation (GO:0006354)3.24484292
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.23643456
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23493333
101mitotic spindle assembly checkpoint (GO:0007094)3.21815796
102DNA deamination (GO:0045006)3.21104705
103G1/S transition of mitotic cell cycle (GO:0000082)3.20642317
104cell cycle G1/S phase transition (GO:0044843)3.20642317
105mitotic recombination (GO:0006312)3.19781210
106regulation of ubiquitin-protein transferase activity (GO:0051438)3.18662075
107spindle assembly checkpoint (GO:0071173)3.18489189
108protein K6-linked ubiquitination (GO:0085020)3.17496472
109DNA catabolic process, exonucleolytic (GO:0000738)3.17275954
110cytochrome complex assembly (GO:0017004)3.15904380
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14844009
112regulation of mitotic spindle organization (GO:0060236)3.13858817
113protein localization to kinetochore (GO:0034501)3.13421283
114blastocyst development (GO:0001824)3.12515100
115DNA damage response, detection of DNA damage (GO:0042769)3.11684980
116histone mRNA metabolic process (GO:0008334)3.10395750
117positive regulation of viral transcription (GO:0050434)3.09767012
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08767833
119regulation of mitotic spindle checkpoint (GO:1903504)3.08767833
120regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06404462
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04917927
122regulation of mitochondrial translation (GO:0070129)3.03620346
123protein targeting to mitochondrion (GO:0006626)3.02985846
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02840054
125regulation of chromosome segregation (GO:0051983)3.02609723
126translational termination (GO:0006415)3.01158736
127regulation of ligase activity (GO:0051340)3.01101602
128establishment of integrated proviral latency (GO:0075713)2.99043877
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97941367
130tRNA processing (GO:0008033)2.96457961
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.94960146
132protein localization to mitochondrion (GO:0070585)2.92286801
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.91067881
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.88463902
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88463902
136organelle disassembly (GO:1903008)2.88121389
137pseudouridine synthesis (GO:0001522)2.88021394
138establishment of protein localization to mitochondrion (GO:0072655)2.87569822
139inner mitochondrial membrane organization (GO:0007007)2.86952491
140preassembly of GPI anchor in ER membrane (GO:0016254)2.85705706
141respiratory electron transport chain (GO:0022904)2.85032133
142ubiquinone biosynthetic process (GO:0006744)2.83326905
143recombinational repair (GO:0000725)2.82458612
144electron transport chain (GO:0022900)2.81865546
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81517888
146ubiquinone metabolic process (GO:0006743)2.81175626
147intraciliary transport (GO:0042073)2.80571663
148double-strand break repair via homologous recombination (GO:0000724)2.79103944
149protein-cofactor linkage (GO:0018065)2.78126657
150mitochondrial RNA metabolic process (GO:0000959)2.76818851
151tRNA metabolic process (GO:0006399)2.75570529
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.74159770
153intracellular protein transmembrane import (GO:0044743)2.74074442
154resolution of meiotic recombination intermediates (GO:0000712)2.73753999
155DNA replication-dependent nucleosome assembly (GO:0006335)2.72036810
156DNA replication-dependent nucleosome organization (GO:0034723)2.72036810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13909027
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70931886
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09825194
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.02514253
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.88461683
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.78759696
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59813609
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48346557
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.45069877
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40062154
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.32972552
12ZNF274_21170338_ChIP-Seq_K562_Hela3.17419557
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08306506
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95944278
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84708436
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83419974
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80279946
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78371369
19* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69027650
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60111743
21* VDR_23849224_ChIP-Seq_CD4+_Human2.58212416
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55515760
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44650948
24* ELK1_19687146_ChIP-ChIP_HELA_Human2.35597564
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35366920
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33435957
27DCP1A_22483619_ChIP-Seq_HELA_Human2.31488576
28XRN2_22483619_ChIP-Seq_HELA_Human2.28561688
29IGF1R_20145208_ChIP-Seq_DFB_Human2.24481795
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18532888
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14084136
32AR_21909140_ChIP-Seq_LNCAP_Human2.13634528
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11480890
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11384876
35FOXP3_21729870_ChIP-Seq_TREG_Human2.08102497
36GABP_19822575_ChIP-Seq_HepG2_Human1.99992616
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99090551
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98653594
39VDR_22108803_ChIP-Seq_LS180_Human1.97638995
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.92298133
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90769187
42TTF2_22483619_ChIP-Seq_HELA_Human1.87857630
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87295176
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84812116
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84245158
46EWS_26573619_Chip-Seq_HEK293_Human1.82301039
47FUS_26573619_Chip-Seq_HEK293_Human1.80783856
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79662629
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76238116
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73400393
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.71474565
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70677971
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70403737
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65244604
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63849615
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.59945961
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58557737
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.56561931
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52547076
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48833039
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43758405
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.43277234
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.42768406
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39593984
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.39046932
66* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.36689554
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33127175
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28617585
69P300_19829295_ChIP-Seq_ESCs_Human1.28135792
70KDM5A_27292631_Chip-Seq_BREAST_Human1.25988772
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25054977
72GBX2_23144817_ChIP-Seq_PC3_Human1.24861232
73TAF15_26573619_Chip-Seq_HEK293_Human1.23967350
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20442140
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19913460
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19587481
77MYC_18940864_ChIP-ChIP_HL60_Human1.16244186
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12457565
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10320256
80* SOX17_20123909_ChIP-Seq_XEN_Mouse1.09635401
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09342099
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07090128
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06607354
84TP53_22573176_ChIP-Seq_HFKS_Human1.06329630
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05935151
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05130091
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04674084
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.03893428
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02999446
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02880820
91TFEB_21752829_ChIP-Seq_HELA_Human1.01734288
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99197016
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98696245
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97916708
95ER_23166858_ChIP-Seq_MCF-7_Human0.97787870
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97565711
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96856334
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96682745
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96236855
100CBP_20019798_ChIP-Seq_JUKART_Human0.96236855
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95996718
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95932309
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95142647
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95142647
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95142647
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94172389
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94039650
108IRF1_19129219_ChIP-ChIP_H3396_Human0.91998906
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91246543
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90767483
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90435350
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.89355535
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89113044
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.88054224
115CIITA_25753668_ChIP-Seq_RAJI_Human0.87736389
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86279828
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85781957
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85338691
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84642808
120* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83360854
121* FOXA1_25329375_ChIP-Seq_VCAP_Human0.83360854
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83270376
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83014226
124NANOG_19829295_ChIP-Seq_ESCs_Human0.82596770
125SOX2_19829295_ChIP-Seq_ESCs_Human0.82596770
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82381046
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82255121
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82120289
129* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82065377
130* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81477753
131NCOR_22424771_ChIP-Seq_293T_Human0.80795569
132AR_20517297_ChIP-Seq_VCAP_Human0.80583133
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80109419
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.79131415
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78576199
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78172515
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77152575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63257600
2MP0010094_abnormal_chromosome_stability4.23959654
3MP0004957_abnormal_blastocyst_morpholog4.19539968
4MP0003111_abnormal_nucleus_morphology4.10287853
5MP0008057_abnormal_DNA_replication4.01227584
6MP0003077_abnormal_cell_cycle3.77467130
7MP0008058_abnormal_DNA_repair3.58945148
8MP0003718_maternal_effect3.50462306
9MP0008007_abnormal_cellular_replicative2.83636680
10MP0008932_abnormal_embryonic_tissue2.83506459
11MP0003786_premature_aging2.60470146
12MP0003123_paternal_imprinting2.57225203
13MP0008877_abnormal_DNA_methylation2.52088049
14MP0003315_abnormal_perineum_morphology2.12813963
15MP0003787_abnormal_imprinting2.11943626
16MP0003136_yellow_coat_color2.05956026
17MP0001730_embryonic_growth_arrest1.89727955
18MP0006292_abnormal_olfactory_placode1.86628250
19MP0008260_abnormal_autophagy1.83300134
20MP0002837_dystrophic_cardiac_calcinosis1.78825237
21MP0006035_abnormal_mitochondrial_morpho1.76967029
22MP0000350_abnormal_cell_proliferation1.74036376
23MP0003880_abnormal_central_pattern1.65165975
24MP0002102_abnormal_ear_morphology1.59546787
25MP0009697_abnormal_copulation1.56002612
26MP0005379_endocrine/exocrine_gland_phen1.54986925
27MP0003121_genomic_imprinting1.54475476
28MP0005394_taste/olfaction_phenotype1.54167220
29MP0005499_abnormal_olfactory_system1.54167220
30MP0002210_abnormal_sex_determination1.54086850
31MP0003941_abnormal_skin_development1.49679533
32MP0005084_abnormal_gallbladder_morpholo1.47780549
33MP0006036_abnormal_mitochondrial_physio1.46682847
34MP0001984_abnormal_olfaction1.40863372
35MP0001672_abnormal_embryogenesis/_devel1.40215980
36MP0005380_embryogenesis_phenotype1.40215980
37MP0004142_abnormal_muscle_tone1.39375202
38MP0002751_abnormal_autonomic_nervous1.38257446
39MP0001697_abnormal_embryo_size1.36623011
40MP0003567_abnormal_fetal_cardiomyocyte1.36072438
41MP0003806_abnormal_nucleotide_metabolis1.34778067
42MP0002234_abnormal_pharynx_morphology1.34026932
43MP0010307_abnormal_tumor_latency1.33052153
44MP0002736_abnormal_nociception_after1.32451162
45MP0009333_abnormal_splenocyte_physiolog1.31622704
46MP0000647_abnormal_sebaceous_gland1.29287513
47MP0010030_abnormal_orbit_morphology1.29105644
48MP0000631_abnormal_neuroendocrine_gland1.28475196
49MP0006276_abnormal_autonomic_nervous1.28164867
50MP0003950_abnormal_plasma_membrane1.26682328
51MP0009046_muscle_twitch1.26616327
52MP0002638_abnormal_pupillary_reflex1.25581564
53MP0003646_muscle_fatigue1.24886940
54MP0003937_abnormal_limbs/digits/tail_de1.24876024
55MP0005075_abnormal_melanosome_morpholog1.24020912
56MP0001145_abnormal_male_reproductive1.22835470
57MP0003186_abnormal_redox_activity1.21576346
58MP0000537_abnormal_urethra_morphology1.20516683
59MP0001119_abnormal_female_reproductive1.20227125
60MP0000653_abnormal_sex_gland1.19942358
61MP0001764_abnormal_homeostasis1.19083024
62MP0001929_abnormal_gametogenesis1.18816251
63MP0003122_maternal_imprinting1.18724772
64MP0002085_abnormal_embryonic_tissue1.17019638
65MP0001529_abnormal_vocalization1.16530495
66MP0002080_prenatal_lethality1.16457804
67MP0003984_embryonic_growth_retardation1.15341369
68MP0005645_abnormal_hypothalamus_physiol1.15234114
69MP0005551_abnormal_eye_electrophysiolog1.15197752
70MP0005187_abnormal_penis_morphology1.13880479
71MP0001293_anophthalmia1.13628770
72MP0000313_abnormal_cell_death1.11377830
73MP0002088_abnormal_embryonic_growth/wei1.10843575
74MP0002233_abnormal_nose_morphology1.08818063
75MP0003195_calcinosis1.06695426
76MP0002938_white_spotting1.04546537
77MP0000358_abnormal_cell_content/1.03431172
78MP0005395_other_phenotype1.02904413
79MP0002163_abnormal_gland_morphology1.01679626
80MP0002277_abnormal_respiratory_mucosa0.99598312
81MP0005646_abnormal_pituitary_gland0.97877083
82MP0000049_abnormal_middle_ear0.97794806
83MP0001968_abnormal_touch/_nociception0.97181698
84MP0002396_abnormal_hematopoietic_system0.95856966
85MP0002019_abnormal_tumor_incidence0.95216598
86MP0005389_reproductive_system_phenotype0.94515571
87MP0005408_hypopigmentation0.93967598
88MP0003890_abnormal_embryonic-extraembry0.93504275
89MP0002084_abnormal_developmental_patter0.92353602
90MP0002095_abnormal_skin_pigmentation0.92245328
91MP0002160_abnormal_reproductive_system0.91998966
92MP0000427_abnormal_hair_cycle0.90772860
93MP0005171_absent_coat_pigmentation0.90564031
94MP0001542_abnormal_bone_strength0.90166971
95MP0008872_abnormal_physiological_respon0.89907735
96MP0002086_abnormal_extraembryonic_tissu0.89620626
97MP0003938_abnormal_ear_development0.89392991
98MP0003011_delayed_dark_adaptation0.89118201
99MP0001727_abnormal_embryo_implantation0.88656200
100MP0000516_abnormal_urinary_system0.88138795
101MP0005367_renal/urinary_system_phenotyp0.88138795
102MP0004215_abnormal_myocardial_fiber0.87262218
103MP0001286_abnormal_eye_development0.86529748
104MP0002132_abnormal_respiratory_system0.86481889
105MP0008875_abnormal_xenobiotic_pharmacok0.86191428
106MP0004147_increased_porphyrin_level0.84385071
107MP0001986_abnormal_taste_sensitivity0.82007533
108MP0000490_abnormal_crypts_of0.77467197
109MP0008995_early_reproductive_senescence0.76999867
110MP0001485_abnormal_pinna_reflex0.75608989
111MP0002090_abnormal_vision0.74915089
112MP0000372_irregular_coat_pigmentation0.74494276
113MP0004197_abnormal_fetal_growth/weight/0.72122811
114MP0003755_abnormal_palate_morphology0.70670404
115MP0008789_abnormal_olfactory_epithelium0.70488630
116MP0005248_abnormal_Harderian_gland0.69504240
117MP0005195_abnormal_posterior_eye0.69273480
118MP0005451_abnormal_body_composition0.69246023
119MP0001661_extended_life_span0.68631363
120MP0006072_abnormal_retinal_apoptosis0.68391306
121MP0005410_abnormal_fertilization0.68299790
122MP0003119_abnormal_digestive_system0.67349649
123MP0002254_reproductive_system_inflammat0.67088990
124MP0004808_abnormal_hematopoietic_stem0.66475950
125MP0002653_abnormal_ependyma_morphology0.65447823
126MP0002752_abnormal_somatic_nervous0.65033856
127MP0005384_cellular_phenotype0.64947621
128MP0003699_abnormal_female_reproductive0.64227156
129MP0002282_abnormal_trachea_morphology0.63448415
130MP0003878_abnormal_ear_physiology0.63328537
131MP0005377_hearing/vestibular/ear_phenot0.63328537
132MP0002111_abnormal_tail_morphology0.62922836
133MP0002127_abnormal_cardiovascular_syste0.62744718
134MP0009053_abnormal_anal_canal0.61305885
135MP0002161_abnormal_fertility/fecundity0.61168041
136MP0005621_abnormal_cell_physiology0.59282701
137MP0001919_abnormal_reproductive_system0.57670767
138MP0005253_abnormal_eye_physiology0.57536328
139MP0005391_vision/eye_phenotype0.57236882
140MP0004133_heterotaxia0.57125724
141MP0001188_hyperpigmentation0.56337535
142MP0003698_abnormal_male_reproductive0.56066903
143MP0000858_altered_metastatic_potential0.55229703
144MP0000383_abnormal_hair_follicle0.55228918

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.84297087
2Breast hypoplasia (HP:0003187)4.61046070
3Carpal bone hypoplasia (HP:0001498)3.68782186
4Patellar aplasia (HP:0006443)3.57367190
5Reticulocytopenia (HP:0001896)3.50092373
6Aplasia/Hypoplasia of the patella (HP:0006498)3.37910436
7Degeneration of anterior horn cells (HP:0002398)3.26816899
8Abnormality of the anterior horn cell (HP:0006802)3.26816899
9Cerebral hypomyelination (HP:0006808)3.13888545
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13817095
11Hepatocellular necrosis (HP:0001404)3.11418576
12Chromsome breakage (HP:0040012)3.08209840
13Abnormality of midbrain morphology (HP:0002418)3.05116377
14Molar tooth sign on MRI (HP:0002419)3.05116377
15Absent radius (HP:0003974)3.04415322
16Meckel diverticulum (HP:0002245)3.01353399
17Rough bone trabeculation (HP:0100670)2.94448408
18Abnormality of the labia minora (HP:0012880)2.90794143
19Aplasia involving forearm bones (HP:0009822)2.86445405
20Absent forearm bone (HP:0003953)2.86445405
21Medial flaring of the eyebrow (HP:0010747)2.82838488
22Impulsivity (HP:0100710)2.81079417
23Hepatic necrosis (HP:0002605)2.80535862
24Abnormality of the ileum (HP:0001549)2.80532020
25Supernumerary spleens (HP:0009799)2.78772409
26Methylmalonic acidemia (HP:0002912)2.78702035
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77861870
28Abnormality of the preputium (HP:0100587)2.72570234
29Irregular epiphyses (HP:0010582)2.71114712
30Increased serum pyruvate (HP:0003542)2.67608066
31Abnormality of glycolysis (HP:0004366)2.67608066
32Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66112060
33Abnormality of chromosome stability (HP:0003220)2.65744144
34Abnormality of cells of the erythroid lineage (HP:0012130)2.65201120
35Macrocytic anemia (HP:0001972)2.57919297
36Nephronophthisis (HP:0000090)2.53432991
37Abnormal number of erythroid precursors (HP:0012131)2.48589588
38Renal Fanconi syndrome (HP:0001994)2.47824792
39Duplicated collecting system (HP:0000081)2.47029702
40Flat capital femoral epiphysis (HP:0003370)2.46205109
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.45234100
42Cerebral edema (HP:0002181)2.43746385
43Congenital primary aphakia (HP:0007707)2.43433239
44Pancreatic cysts (HP:0001737)2.42878003
45Abnormal lung lobation (HP:0002101)2.42805221
46Acute necrotizing encephalopathy (HP:0006965)2.41324216
47Methylmalonic aciduria (HP:0012120)2.38835447
483-Methylglutaconic aciduria (HP:0003535)2.38495928
49Duodenal stenosis (HP:0100867)2.36709327
50Small intestinal stenosis (HP:0012848)2.36709327
51Nephrogenic diabetes insipidus (HP:0009806)2.36302408
52Horseshoe kidney (HP:0000085)2.35711090
53Type II lissencephaly (HP:0007260)2.34863254
54Gait imbalance (HP:0002141)2.34658132
55Ureteral duplication (HP:0000073)2.33234905
56Premature graying of hair (HP:0002216)2.32152354
57Abnormal trabecular bone morphology (HP:0100671)2.32081338
58Cleft eyelid (HP:0000625)2.31290063
59Abnormality of the renal cortex (HP:0011035)2.30810991
60Secondary amenorrhea (HP:0000869)2.29738469
61Hyperglycinemia (HP:0002154)2.27082574
62Aplasia/Hypoplasia involving the musculature (HP:0001460)2.25872145
63Lactic acidosis (HP:0003128)2.25731435
64Abnormal protein glycosylation (HP:0012346)2.24696660
65Abnormal glycosylation (HP:0012345)2.24696660
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24696660
67Abnormal protein N-linked glycosylation (HP:0012347)2.24696660
68Abnormal biliary tract physiology (HP:0012439)2.24391570
69Bile duct proliferation (HP:0001408)2.24391570
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24017984
71Absent epiphyses (HP:0010577)2.24017984
72Oral leukoplakia (HP:0002745)2.22732591
73Adrenal hypoplasia (HP:0000835)2.22695917
74Pallor (HP:0000980)2.22020248
75Abnormal spermatogenesis (HP:0008669)2.21055706
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.20617564
77Pancreatic fibrosis (HP:0100732)2.19925611
78Aplastic anemia (HP:0001915)2.19742532
79Absent thumb (HP:0009777)2.19473642
80Abnormality of the renal medulla (HP:0100957)2.18966865
81Agnosia (HP:0010524)2.16483374
82Chronic hepatic failure (HP:0100626)2.16064605
83Type I transferrin isoform profile (HP:0003642)2.15696775
84Bone marrow hypocellularity (HP:0005528)2.13829820
85Aplasia/hypoplasia of the uterus (HP:0008684)2.13121961
86Spinal muscular atrophy (HP:0007269)2.12681740
87Congenital, generalized hypertrichosis (HP:0004540)2.10087390
88Increased hepatocellular lipid droplets (HP:0006565)2.09734437
89Poor head control (HP:0002421)2.07675012
90Optic disc pallor (HP:0000543)2.06854326
91Sloping forehead (HP:0000340)2.05422608
92Triphalangeal thumb (HP:0001199)2.05418561
93Premature ovarian failure (HP:0008209)2.05250960
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04720563
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04720563
96Abnormality of the renal collecting system (HP:0004742)2.02322306
97Myelodysplasia (HP:0002863)2.01833526
98Abnormal mitochondria in muscle tissue (HP:0008316)2.00725582
99Mitochondrial inheritance (HP:0001427)1.99475407
100Postaxial foot polydactyly (HP:0001830)1.99469887
101Sclerocornea (HP:0000647)1.99435492
102Genital tract atresia (HP:0001827)1.99325094
103Increased intramyocellular lipid droplets (HP:0012240)1.98316179
104Breast aplasia (HP:0100783)1.97884921
105Respiratory failure (HP:0002878)1.94876204
106True hermaphroditism (HP:0010459)1.94813305
107Stenosis of the external auditory canal (HP:0000402)1.94552927
108Abnormality of the pons (HP:0007361)1.93706779
109Intestinal atresia (HP:0011100)1.93370699
110Median cleft lip (HP:0000161)1.93345696
111Vaginal atresia (HP:0000148)1.93115851
112Abnormality of the duodenum (HP:0002246)1.92567262
113Lethargy (HP:0001254)1.92065656
114Aplasia/Hypoplasia of the breasts (HP:0010311)1.92056979
11511 pairs of ribs (HP:0000878)1.91940047
116Short tibia (HP:0005736)1.91388311
117Increased CSF lactate (HP:0002490)1.91200495
118Microretrognathia (HP:0000308)1.89523214
119Multiple enchondromatosis (HP:0005701)1.89445905
120Exertional dyspnea (HP:0002875)1.89111784
121Sparse lateral eyebrow (HP:0005338)1.88387940
122Small epiphyses (HP:0010585)1.86619992
123Progressive macrocephaly (HP:0004481)1.85995429
124Congenital stationary night blindness (HP:0007642)1.85302487
125Hypothermia (HP:0002045)1.84394666
126Nephroblastoma (Wilms tumor) (HP:0002667)1.84372728
127Lissencephaly (HP:0001339)1.84268625
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84080263
129Preaxial hand polydactyly (HP:0001177)1.84054624
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.83562186
131Progressive inability to walk (HP:0002505)1.82150306
132Postaxial hand polydactyly (HP:0001162)1.82020851
133Microvesicular hepatic steatosis (HP:0001414)1.81835486
134Anencephaly (HP:0002323)1.81427919
135Colon cancer (HP:0003003)1.81365028
136Dandy-Walker malformation (HP:0001305)1.80625337
137Abnormality of the umbilical cord (HP:0010881)1.79460226
138Renal cortical cysts (HP:0000803)1.78415084
139Short middle phalanx of the 5th finger (HP:0004220)1.78304223
140Hypoplasia of the uterus (HP:0000013)1.78199920
141Embryonal renal neoplasm (HP:0011794)1.78151308
142Sparse eyelashes (HP:0000653)1.77930210
143Reduced antithrombin III activity (HP:0001976)1.77682716
144Acute encephalopathy (HP:0006846)1.76951978
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76869368
146Abnormality of methionine metabolism (HP:0010901)1.76617728
147Exercise intolerance (HP:0003546)1.76589656
148Increased serum lactate (HP:0002151)1.75974730
149Hypoplasia of the pons (HP:0012110)1.75789822
150Abnormality of the metopic suture (HP:0005556)1.75717306
151CNS demyelination (HP:0007305)1.74862835
152Poor coordination (HP:0002370)1.74101876
153Cellular immunodeficiency (HP:0005374)1.73990135
154Bifid tongue (HP:0010297)1.72986464
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71297992
156CNS hypomyelination (HP:0003429)1.69684522
157Capillary hemangiomas (HP:0005306)1.69632874
158Prolonged neonatal jaundice (HP:0006579)1.69300121
159Selective tooth agenesis (HP:0001592)1.69059791
160Ectopic kidney (HP:0000086)1.69041215
161Lipid accumulation in hepatocytes (HP:0006561)1.68313580
162Slender long bone (HP:0003100)1.67893714
163Abnormality of the proximal phalanges of the hand (HP:0009834)1.66749487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.07711720
2WEE13.82691876
3EIF2AK13.80448475
4PLK43.01648444
5MAP4K22.97716657
6STK162.84643294
7BRSK22.84378108
8SRPK12.76776102
9NME22.64267593
10PBK2.44380038
11VRK22.41426734
12CCNB12.27790058
13ACVR1B2.22766820
14EIF2AK32.22739909
15TRIM282.18786640
16CDC72.11408626
17VRK12.11054474
18PLK32.01986051
19TSSK61.96428528
20MKNK11.89464410
21PLK11.87694155
22ARAF1.86042988
23BRAF1.81020307
24MKNK21.80852886
25CDK191.80806421
26TTK1.80015862
27NEK21.76983259
28AKT31.72008947
29MAP3K41.67905505
30FRK1.59855778
31MST41.56256880
32MAP2K71.54238372
33PINK11.51595267
34PIM21.50643722
35ZAK1.50436105
36BRSK11.44728684
37STK38L1.44269940
38DYRK31.42107062
39BCKDK1.41504943
40AURKB1.33213157
41EIF2AK21.29267925
42CASK1.27398195
43ADRBK21.23336450
44MAP3K121.23230022
45CSNK1G21.22442999
46EPHA21.19721151
47CHEK21.15013995
48TNIK1.14113804
49TESK21.13760762
50NEK11.13053048
51ATR1.08812374
52AURKA1.05878865
53CDK71.05706500
54OXSR10.99653726
55GRK10.99438165
56STK30.97588285
57DYRK20.96733593
58RPS6KA40.96267651
59PNCK0.94700771
60PASK0.94596037
61TLK10.92257820
62MAPK130.88921032
63BCR0.88433924
64CDK80.83836987
65MAP3K30.82562336
66CHEK10.79237903
67WNK30.78643832
68STK40.78064506
69NME10.77698519
70BMPR1B0.76955095
71NUAK10.76351485
72TAF10.72553227
73BMPR20.72520010
74CSNK2A10.69949747
75MAP3K80.69858056
76STK390.65830942
77RPS6KB20.65336390
78YES10.65011394
79STK240.64345654
80TGFBR10.63390878
81TAOK30.61110878
82INSRR0.59895347
83NEK60.59764068
84ERBB30.57989012
85WNK40.56499633
86ABL20.56271711
87CDK30.55672027
88ATM0.55668777
89PAK10.54906862
90CSNK2A20.54181118
91PRKCI0.53937321
92PLK20.53275366
93RPS6KA50.52033054
94PIM10.51358883
95MELK0.51086108
96GRK70.51040966
97CDK10.48810650
98MARK30.48046780
99CDK20.48026997
100LIMK10.48018184
101STK100.45952073
102PRKCE0.42418029
103CSNK1G30.40810827
104IKBKB0.40665878
105PRKCG0.37459862
106ERBB40.37279638
107EPHA40.36708140
108OBSCN0.36103190
109CSNK1A10.35757790
110PAK30.35738355
111NEK90.35155811
112IRAK10.34771743
113CAMKK20.34763923
114MAP3K50.32159328
115TXK0.32118514
116CDK40.30369144
117LATS20.27765193
118RAF10.27112464
119BRD40.26869437
120PIK3CG0.26021905
121TAOK20.25641044
122CLK10.24652385
123PDK30.23776438
124PDK40.23776438
125CSNK1G10.23574247
126CSNK1D0.22584128
127MAPKAPK50.22526567
128PDK20.22301708
129MOS0.22290808
130PRKACB0.22275551
131ADRBK10.22203895
132IRAK40.21603480
133CSNK1E0.19265231
134MYLK0.18286771
135CSNK1A1L0.17860573
136TIE10.17841032

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.54658808
2Proteasome_Homo sapiens_hsa030504.47635362
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85021236
4DNA replication_Homo sapiens_hsa030303.50789248
5Ribosome_Homo sapiens_hsa030103.44761709
6Mismatch repair_Homo sapiens_hsa034303.19743725
7Spliceosome_Homo sapiens_hsa030402.96502017
8RNA transport_Homo sapiens_hsa030132.90079004
9Homologous recombination_Homo sapiens_hsa034402.84137365
10Nucleotide excision repair_Homo sapiens_hsa034202.71381498
11Basal transcription factors_Homo sapiens_hsa030222.71307788
12Vitamin B6 metabolism_Homo sapiens_hsa007502.68686200
13Pyrimidine metabolism_Homo sapiens_hsa002402.66486637
14Cell cycle_Homo sapiens_hsa041102.54479913
15Base excision repair_Homo sapiens_hsa034102.45210563
16Fanconi anemia pathway_Homo sapiens_hsa034602.12720542
17Non-homologous end-joining_Homo sapiens_hsa034501.86386946
18RNA degradation_Homo sapiens_hsa030181.84516336
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84307964
20Propanoate metabolism_Homo sapiens_hsa006401.76456521
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74559373
22Purine metabolism_Homo sapiens_hsa002301.66969903
23Protein export_Homo sapiens_hsa030601.63200826
24One carbon pool by folate_Homo sapiens_hsa006701.56055956
25p53 signaling pathway_Homo sapiens_hsa041151.49104447
26Oxidative phosphorylation_Homo sapiens_hsa001901.37966129
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36040089
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33776138
29Epstein-Barr virus infection_Homo sapiens_hsa051691.28921204
30Huntingtons disease_Homo sapiens_hsa050161.27542151
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25646147
32Folate biosynthesis_Homo sapiens_hsa007901.21822188
33mRNA surveillance pathway_Homo sapiens_hsa030151.19811523
34Parkinsons disease_Homo sapiens_hsa050121.16417294
35Fatty acid elongation_Homo sapiens_hsa000621.14451732
36Butanoate metabolism_Homo sapiens_hsa006501.11253136
37Regulation of autophagy_Homo sapiens_hsa041401.04254943
38Phototransduction_Homo sapiens_hsa047441.02531035
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00717339
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99020160
41Oocyte meiosis_Homo sapiens_hsa041140.97401305
42Peroxisome_Homo sapiens_hsa041460.96798391
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96098225
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93130082
45Cardiac muscle contraction_Homo sapiens_hsa042600.84154099
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81322716
47Herpes simplex infection_Homo sapiens_hsa051680.78743736
48Pyruvate metabolism_Homo sapiens_hsa006200.78457946
49Legionellosis_Homo sapiens_hsa051340.72933115
50Sulfur metabolism_Homo sapiens_hsa009200.70447997
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68929074
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68356177
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67268318
54Rheumatoid arthritis_Homo sapiens_hsa053230.65957642
55Nitrogen metabolism_Homo sapiens_hsa009100.64755607
56Systemic lupus erythematosus_Homo sapiens_hsa053220.60925386
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59178214
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58601480
59Glutathione metabolism_Homo sapiens_hsa004800.58319012
60Arachidonic acid metabolism_Homo sapiens_hsa005900.56897364
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56513535
62Tryptophan metabolism_Homo sapiens_hsa003800.56289138
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56273263
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.56181732
65Graft-versus-host disease_Homo sapiens_hsa053320.56081064
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56054684
67Alzheimers disease_Homo sapiens_hsa050100.55635588
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.54504038
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54183179
70Caffeine metabolism_Homo sapiens_hsa002320.53543862
71Allograft rejection_Homo sapiens_hsa053300.52043402
72Viral carcinogenesis_Homo sapiens_hsa052030.50545424
73Antigen processing and presentation_Homo sapiens_hsa046120.47816979
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46796710
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45373219
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43852486
77Pentose phosphate pathway_Homo sapiens_hsa000300.43653420
78Olfactory transduction_Homo sapiens_hsa047400.40900584
79TGF-beta signaling pathway_Homo sapiens_hsa043500.40307943
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40076772
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40044216
82beta-Alanine metabolism_Homo sapiens_hsa004100.38053922
83Chemical carcinogenesis_Homo sapiens_hsa052040.37015271
84Phagosome_Homo sapiens_hsa041450.36985492
85Metabolic pathways_Homo sapiens_hsa011000.36798633
86HTLV-I infection_Homo sapiens_hsa051660.36773795
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34367142
88Nicotine addiction_Homo sapiens_hsa050330.33129000
89Fatty acid metabolism_Homo sapiens_hsa012120.33000042
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32601162
91Biosynthesis of amino acids_Homo sapiens_hsa012300.32036332
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.31994942
93N-Glycan biosynthesis_Homo sapiens_hsa005100.31670581
94Carbon metabolism_Homo sapiens_hsa012000.31599758
95Sphingolipid metabolism_Homo sapiens_hsa006000.31130933
96Steroid biosynthesis_Homo sapiens_hsa001000.31039334
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30851306
98Apoptosis_Homo sapiens_hsa042100.30704075
99Collecting duct acid secretion_Homo sapiens_hsa049660.30135459
100Asthma_Homo sapiens_hsa053100.29830079
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28032760
102Fatty acid degradation_Homo sapiens_hsa000710.25983755
103Fructose and mannose metabolism_Homo sapiens_hsa000510.25804481
104Autoimmune thyroid disease_Homo sapiens_hsa053200.25501101
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25346595
106Type I diabetes mellitus_Homo sapiens_hsa049400.25043421
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.24864791
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24709557
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.22610854
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22078065
111Alcoholism_Homo sapiens_hsa050340.22069399
112Measles_Homo sapiens_hsa051620.21876239
113Linoleic acid metabolism_Homo sapiens_hsa005910.21679136
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21349570
115Basal cell carcinoma_Homo sapiens_hsa052170.21330229
116Hippo signaling pathway_Homo sapiens_hsa043900.21195328
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21090636
118MicroRNAs in cancer_Homo sapiens_hsa052060.20454914
119Thyroid cancer_Homo sapiens_hsa052160.20187446
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19277782
121Influenza A_Homo sapiens_hsa051640.18920063
122Small cell lung cancer_Homo sapiens_hsa052220.18192777
123Hematopoietic cell lineage_Homo sapiens_hsa046400.17637184
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17327258
125Malaria_Homo sapiens_hsa051440.16689839
126Vitamin digestion and absorption_Homo sapiens_hsa049770.16179094
127Arginine and proline metabolism_Homo sapiens_hsa003300.15277196
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14208846
129Primary immunodeficiency_Homo sapiens_hsa053400.13598774
130Vibrio cholerae infection_Homo sapiens_hsa051100.13503956
131Selenocompound metabolism_Homo sapiens_hsa004500.12835015
132Hedgehog signaling pathway_Homo sapiens_hsa043400.12362042
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11224626
134Shigellosis_Homo sapiens_hsa051310.10702560
135Ether lipid metabolism_Homo sapiens_hsa005650.10547686
136HIF-1 signaling pathway_Homo sapiens_hsa040660.10493599
137Hepatitis B_Homo sapiens_hsa051610.10470153
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07446393
139Circadian rhythm_Homo sapiens_hsa047100.07135515

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