MED4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14003382
2DNA double-strand break processing (GO:0000729)5.00877984
3mitotic metaphase plate congression (GO:0007080)4.97467507
4protein neddylation (GO:0045116)4.39972560
5nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.37598159
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.36918909
7DNA deamination (GO:0045006)4.36890708
8ATP synthesis coupled proton transport (GO:0015986)4.33163033
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33163033
10purine nucleobase biosynthetic process (GO:0009113)4.31933245
11metaphase plate congression (GO:0051310)4.25668552
12CENP-A containing nucleosome assembly (GO:0034080)4.23227130
13DNA replication checkpoint (GO:0000076)4.22812068
14DNA strand elongation involved in DNA replication (GO:0006271)4.22513151
15nucleobase biosynthetic process (GO:0046112)4.20948112
16maturation of SSU-rRNA (GO:0030490)4.14920924
17ribosomal small subunit assembly (GO:0000028)4.11951668
18DNA replication initiation (GO:0006270)4.11216518
19chromatin remodeling at centromere (GO:0031055)4.10547795
20protein localization to kinetochore (GO:0034501)4.07896520
21telomere maintenance via semi-conservative replication (GO:0032201)4.06912945
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06828974
23formation of translation preinitiation complex (GO:0001731)4.04807157
24DNA strand elongation (GO:0022616)4.02958101
25protein complex biogenesis (GO:0070271)3.98410062
26attachment of spindle microtubules to kinetochore (GO:0008608)3.93729411
27respiratory chain complex IV assembly (GO:0008535)3.93452425
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.88807879
29ribosome biogenesis (GO:0042254)3.88097196
30proteasome assembly (GO:0043248)3.87699338
31cytochrome complex assembly (GO:0017004)3.84293422
32mitochondrial respiratory chain complex assembly (GO:0033108)3.82919353
33DNA catabolic process, exonucleolytic (GO:0000738)3.81034133
34DNA replication-independent nucleosome assembly (GO:0006336)3.79072530
35DNA replication-independent nucleosome organization (GO:0034724)3.79072530
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77230752
37establishment of chromosome localization (GO:0051303)3.77109069
38kinetochore organization (GO:0051383)3.76188587
39DNA ligation (GO:0006266)3.74687453
40telomere maintenance via recombination (GO:0000722)3.73151327
41respiratory electron transport chain (GO:0022904)3.72904157
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71528967
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71220367
44ribosome assembly (GO:0042255)3.65969195
45electron transport chain (GO:0022900)3.65870700
46kinetochore assembly (GO:0051382)3.65838397
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63357515
48histone exchange (GO:0043486)3.61844508
497-methylguanosine mRNA capping (GO:0006370)3.61408103
50protein localization to chromosome, centromeric region (GO:0071459)3.60932678
517-methylguanosine RNA capping (GO:0009452)3.54543067
52RNA capping (GO:0036260)3.54543067
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54011793
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.54011793
55NADH dehydrogenase complex assembly (GO:0010257)3.54011793
56mitotic recombination (GO:0006312)3.51993205
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.47208244
58mitotic nuclear envelope disassembly (GO:0007077)3.46901860
59transcription-coupled nucleotide-excision repair (GO:0006283)3.46688168
60synapsis (GO:0007129)3.46091848
61water-soluble vitamin biosynthetic process (GO:0042364)3.45961145
62spliceosomal snRNP assembly (GO:0000387)3.44881702
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.44347166
64termination of RNA polymerase III transcription (GO:0006386)3.44347166
65ribonucleoprotein complex biogenesis (GO:0022613)3.40477723
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40274300
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40274300
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.39405812
69telomere maintenance via telomere lengthening (GO:0010833)3.38978335
70regulation of meiosis I (GO:0060631)3.38073584
71spindle checkpoint (GO:0031577)3.36147008
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35467638
73maturation of 5.8S rRNA (GO:0000460)3.34909338
74mannosylation (GO:0097502)3.34702174
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33475790
76negative regulation of ligase activity (GO:0051352)3.33475790
77regulation of spindle organization (GO:0090224)3.33202106
78termination of RNA polymerase I transcription (GO:0006363)3.32891329
79rRNA methylation (GO:0031167)3.32285074
80rRNA modification (GO:0000154)3.31018974
81transcription elongation from RNA polymerase I promoter (GO:0006362)3.30774590
82protein deneddylation (GO:0000338)3.30535881
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30493057
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.29265867
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29265867
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29265867
87negative regulation of sister chromatid segregation (GO:0033046)3.29265867
88protein K6-linked ubiquitination (GO:0085020)3.29004878
89mitotic chromosome condensation (GO:0007076)3.28840585
90chaperone-mediated protein transport (GO:0072321)3.28034235
91cullin deneddylation (GO:0010388)3.27627026
92rRNA processing (GO:0006364)3.27277156
93negative regulation of chromosome segregation (GO:0051985)3.27248785
94IMP biosynthetic process (GO:0006188)3.27245951
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23823297
96meiotic chromosome segregation (GO:0045132)3.23696475
97DNA replication-dependent nucleosome organization (GO:0034723)3.22134083
98DNA replication-dependent nucleosome assembly (GO:0006335)3.22134083
99cell cycle G1/S phase transition (GO:0044843)3.22058632
100G1/S transition of mitotic cell cycle (GO:0000082)3.22058632
101mitotic spindle assembly checkpoint (GO:0007094)3.21309471
102spindle assembly checkpoint (GO:0071173)3.20275573
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20225617
104nuclear envelope disassembly (GO:0051081)3.20149371
105membrane disassembly (GO:0030397)3.20149371
106DNA unwinding involved in DNA replication (GO:0006268)3.19782806
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.18893565
108transcription from RNA polymerase I promoter (GO:0006360)3.18884688
109regulation of double-strand break repair via homologous recombination (GO:0010569)3.18825342
110mitotic sister chromatid segregation (GO:0000070)3.18625159
111viral mRNA export from host cell nucleus (GO:0046784)3.17960392
112rRNA metabolic process (GO:0016072)3.17870100
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16068789
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16068789
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15711768
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15711768
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15711768
118protein-cofactor linkage (GO:0018065)3.15357066
119regulation of mitochondrial translation (GO:0070129)3.15002781
120positive regulation of ligase activity (GO:0051351)3.14823579
121mitotic spindle checkpoint (GO:0071174)3.13950939
122pseudouridine synthesis (GO:0001522)3.12026836
123cotranslational protein targeting to membrane (GO:0006613)3.10385167
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10251630
125signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09113927
126signal transduction involved in DNA damage checkpoint (GO:0072422)3.09113927
127translational termination (GO:0006415)3.08619042
128resolution of meiotic recombination intermediates (GO:0000712)3.08338939
129signal transduction involved in cell cycle checkpoint (GO:0072395)3.06048956
130regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05796138
131viral transcription (GO:0019083)3.05563018
132regulation of chromosome segregation (GO:0051983)3.05395474
133protein targeting to ER (GO:0045047)3.04375627
134platelet dense granule organization (GO:0060155)3.04248376
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03749800
136ribosomal large subunit biogenesis (GO:0042273)3.02300764
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02123919
138regulation of mitotic spindle checkpoint (GO:1903504)3.01471971
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01471971
140regulation of cellular amino acid metabolic process (GO:0006521)2.99978227
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.99189326
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.98426881
143purine nucleotide salvage (GO:0032261)2.96889112
144translation (GO:0006412)2.95690710
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94729538
146DNA damage response, detection of DNA damage (GO:0042769)2.94396313
147establishment of integrated proviral latency (GO:0075713)2.94357341
148protein K11-linked ubiquitination (GO:0070979)2.90224681
149protein localization to endoplasmic reticulum (GO:0070972)2.89632314
150oxidative phosphorylation (GO:0006119)2.89180353
151ubiquinone biosynthetic process (GO:0006744)2.88568288
152replication fork processing (GO:0031297)2.86810760
153postreplication repair (GO:0006301)2.83472710
154recombinational repair (GO:0000725)2.83198540
155double-strand break repair via homologous recombination (GO:0000724)2.82028655
156translational initiation (GO:0006413)2.80187903
157piRNA metabolic process (GO:0034587)2.79863728
158purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.75138830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72074636
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20903389
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87432239
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.75888159
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65160947
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.53662956
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.53150860
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47016641
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36987022
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25042287
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18010081
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17395512
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93920841
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86568045
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82595927
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72762198
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71191156
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64515208
19* VDR_23849224_ChIP-Seq_CD4+_Human2.54884400
20ZNF274_21170338_ChIP-Seq_K562_Hela2.52028262
21IGF1R_20145208_ChIP-Seq_DFB_Human2.50037288
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48591090
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46943295
24XRN2_22483619_ChIP-Seq_HELA_Human2.33188203
25VDR_22108803_ChIP-Seq_LS180_Human2.29699398
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27298375
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23500714
28FOXP3_21729870_ChIP-Seq_TREG_Human2.19232997
29DCP1A_22483619_ChIP-Seq_HELA_Human2.14442264
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13597127
31* GABP_19822575_ChIP-Seq_HepG2_Human2.11282557
32EWS_26573619_Chip-Seq_HEK293_Human2.09581205
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07745744
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07588228
35AR_21909140_ChIP-Seq_LNCAP_Human2.06447182
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06301220
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00928785
38FLI1_27457419_Chip-Seq_LIVER_Mouse2.00044936
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94291516
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93357291
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89998158
42TTF2_22483619_ChIP-Seq_HELA_Human1.89579307
43FUS_26573619_Chip-Seq_HEK293_Human1.89102339
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.88706992
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.88238080
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86942469
47ELK1_19687146_ChIP-ChIP_HELA_Human1.84677666
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81630004
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81218167
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77206289
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75894796
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75623573
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.69294485
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68545642
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67259190
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66118761
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.59772639
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59624889
59CIITA_25753668_ChIP-Seq_RAJI_Human1.58607775
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58299572
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56203948
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53736483
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51399458
64KDM5A_27292631_Chip-Seq_BREAST_Human1.50621410
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.50019128
66P300_19829295_ChIP-Seq_ESCs_Human1.49601181
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45235990
68TAF15_26573619_Chip-Seq_HEK293_Human1.43911747
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43349490
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43037290
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43025585
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41854747
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41680313
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37810338
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33789255
76IRF1_19129219_ChIP-ChIP_H3396_Human1.33171082
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32303215
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31769617
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30629663
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27916062
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27853351
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26397054
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24577935
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.20733882
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18562447
86SOX2_19829295_ChIP-Seq_ESCs_Human1.17833018
87NANOG_19829295_ChIP-Seq_ESCs_Human1.17833018
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17784361
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16997216
90TP53_22573176_ChIP-Seq_HFKS_Human1.13311847
91MYC_18940864_ChIP-ChIP_HL60_Human1.13281413
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12589431
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.12589431
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12514228
95TFEB_21752829_ChIP-Seq_HELA_Human1.09835315
96* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09742970
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09446103
98ER_23166858_ChIP-Seq_MCF-7_Human1.08892417
99NANOG_16153702_ChIP-ChIP_HESCs_Human1.06022062
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.04645630
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04415048
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03738547
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.03450244
104MYC_22102868_ChIP-Seq_BL_Human1.02964234
105HTT_18923047_ChIP-ChIP_STHdh_Human1.02962104
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02661418
107GBX2_23144817_ChIP-Seq_PC3_Human1.01327502
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01045713
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00148918
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99855725
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99733609
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99103121
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.98814440
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98117370
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97742651
116CBP_20019798_ChIP-Seq_JUKART_Human0.97742651
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.97020114
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96506148
119AR_20517297_ChIP-Seq_VCAP_Human0.96455285
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95645750
121SPI1_23547873_ChIP-Seq_NB4_Human0.94151226
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90528645
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90291226
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89433541
125* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88576433
126* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87951425
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87885486
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87650946
129* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87413428
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.87301963
131BCAT_22108803_ChIP-Seq_LS180_Human0.86946251
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85788229
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85421654
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85294037
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84219175
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83200577
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83144320
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82545273
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80537128
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78917785
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76661813
142NANOG_21062744_ChIP-ChIP_HESCs_Human0.74570632
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73454835
144SALL1_21062744_ChIP-ChIP_HESCs_Human0.72989100
145IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72458290
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70576608
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67400731
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66092142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.85422879
2MP0010094_abnormal_chromosome_stability4.85230037
3MP0004957_abnormal_blastocyst_morpholog4.50015222
4MP0003111_abnormal_nucleus_morphology4.40618794
5MP0003077_abnormal_cell_cycle4.21664144
6MP0008058_abnormal_DNA_repair4.11693481
7MP0008057_abnormal_DNA_replication3.69871173
8MP0008877_abnormal_DNA_methylation3.34734066
9MP0008007_abnormal_cellular_replicative3.15174680
10MP0005084_abnormal_gallbladder_morpholo2.81082724
11MP0003123_paternal_imprinting2.79526062
12MP0003786_premature_aging2.74784068
13MP0008932_abnormal_embryonic_tissue2.62686361
14MP0006072_abnormal_retinal_apoptosis2.39056632
15MP0002396_abnormal_hematopoietic_system2.28088581
16MP0003787_abnormal_imprinting2.24397208
17MP0000372_irregular_coat_pigmentation2.21702294
18MP0003718_maternal_effect2.19381615
19MP0001730_embryonic_growth_arrest2.09849608
20MP0002837_dystrophic_cardiac_calcinosis2.08891737
21MP0001529_abnormal_vocalization2.06618471
22MP0000350_abnormal_cell_proliferation2.05193975
23MP0002210_abnormal_sex_determination1.80558824
24MP0003195_calcinosis1.64234603
25MP0006292_abnormal_olfactory_placode1.60050680
26MP0003315_abnormal_perineum_morphology1.57513710
27MP0001697_abnormal_embryo_size1.56447923
28MP0001672_abnormal_embryogenesis/_devel1.55399433
29MP0005380_embryogenesis_phenotype1.55399433
30MP0008260_abnormal_autophagy1.54259612
31MP0003121_genomic_imprinting1.53076849
32MP0002277_abnormal_respiratory_mucosa1.52939720
33MP0004215_abnormal_myocardial_fiber1.51817905
34MP0003763_abnormal_thymus_physiology1.51630698
35MP0003880_abnormal_central_pattern1.46726171
36MP0001145_abnormal_male_reproductive1.46626972
37MP0008872_abnormal_physiological_respon1.46024107
38MP0000313_abnormal_cell_death1.45951169
39MP0002019_abnormal_tumor_incidence1.44490760
40MP0000490_abnormal_crypts_of1.43732180
41MP0001929_abnormal_gametogenesis1.42718351
42MP0008789_abnormal_olfactory_epithelium1.40968271
43MP0003984_embryonic_growth_retardation1.40213584
44MP0002080_prenatal_lethality1.39772407
45MP0009333_abnormal_splenocyte_physiolog1.39519200
46MP0008995_early_reproductive_senescence1.39414920
47MP0004808_abnormal_hematopoietic_stem1.38974208
48MP0005645_abnormal_hypothalamus_physiol1.37119647
49MP0002736_abnormal_nociception_after1.34986670
50MP0002088_abnormal_embryonic_growth/wei1.34882023
51MP0000653_abnormal_sex_gland1.34495363
52MP0005253_abnormal_eye_physiology1.32693914
53MP0002638_abnormal_pupillary_reflex1.32258281
54MP0010307_abnormal_tumor_latency1.30658227
55MP0001119_abnormal_female_reproductive1.28537448
56MP0009697_abnormal_copulation1.27912726
57MP0001984_abnormal_olfaction1.27267800
58MP0003567_abnormal_fetal_cardiomyocyte1.26640381
59MP0002085_abnormal_embryonic_tissue1.26609741
60MP0005646_abnormal_pituitary_gland1.22305677
61MP0002132_abnormal_respiratory_system1.22301593
62MP0003011_delayed_dark_adaptation1.21512251
63MP0010352_gastrointestinal_tract_polyps1.13360073
64MP0002160_abnormal_reproductive_system1.12511514
65MP0002084_abnormal_developmental_patter1.11600844
66MP0003941_abnormal_skin_development1.09790981
67MP0003806_abnormal_nucleotide_metabolis1.09519406
68MP0004145_abnormal_muscle_electrophysio1.08995024
69MP0003136_yellow_coat_color1.06884899
70MP0005551_abnormal_eye_electrophysiolog1.06608228
71MP0002398_abnormal_bone_marrow1.05942893
72MP0004142_abnormal_muscle_tone1.05284979
73MP0005389_reproductive_system_phenotype1.05270374
74MP0002086_abnormal_extraembryonic_tissu1.04205509
75MP0001545_abnormal_hematopoietic_system1.03900245
76MP0005397_hematopoietic_system_phenotyp1.03900245
77MP0000703_abnormal_thymus_morphology1.02139871
78MP0002751_abnormal_autonomic_nervous1.01799675
79MP0005379_endocrine/exocrine_gland_phen1.00832441
80MP0006276_abnormal_autonomic_nervous0.99285080
81MP0002722_abnormal_immune_system0.98556301
82MP0000689_abnormal_spleen_morphology0.98323659
83MP0003890_abnormal_embryonic-extraembry0.97669772
84MP0001293_anophthalmia0.96244173
85MP0010030_abnormal_orbit_morphology0.96197255
86MP0003186_abnormal_redox_activity0.95782811
87MP0009379_abnormal_foot_pigmentation0.95509624
88MP0000631_abnormal_neuroendocrine_gland0.93136023
89MP0004197_abnormal_fetal_growth/weight/0.91557404
90MP0006036_abnormal_mitochondrial_physio0.90717940
91MP0003221_abnormal_cardiomyocyte_apopto0.90076546
92MP0005394_taste/olfaction_phenotype0.86658225
93MP0005499_abnormal_olfactory_system0.86658225
94MP0005332_abnormal_amino_acid0.86432783
95MP0001986_abnormal_taste_sensitivity0.86381708
96MP0002102_abnormal_ear_morphology0.86085937
97MP0005083_abnormal_biliary_tract0.85825570
98MP0005410_abnormal_fertilization0.84787473
99MP0001968_abnormal_touch/_nociception0.83416384
100MP0000383_abnormal_hair_follicle0.82469032
101MP0002653_abnormal_ependyma_morphology0.82313169
102MP0001905_abnormal_dopamine_level0.81914554
103MP0000358_abnormal_cell_content/0.80817736
104MP0001188_hyperpigmentation0.80034179
105MP0006035_abnormal_mitochondrial_morpho0.79956652
106MP0002429_abnormal_blood_cell0.79724135
107MP0003698_abnormal_male_reproductive0.79602344
108MP0001919_abnormal_reproductive_system0.78958653
109MP0005384_cellular_phenotype0.76213318
110MP0003937_abnormal_limbs/digits/tail_de0.76185156
111MP0001485_abnormal_pinna_reflex0.75573305
112MP0004484_altered_response_of0.75164602
113MP0003119_abnormal_digestive_system0.74859283
114MP0000569_abnormal_digit_pigmentation0.73990544
115MP0005075_abnormal_melanosome_morpholog0.72361577
116MP0006054_spinal_hemorrhage0.71623243
117MP0002876_abnormal_thyroid_physiology0.70296096
118MP0003699_abnormal_female_reproductive0.69964972
119MP0003943_abnormal_hepatobiliary_system0.69699790
120MP0000427_abnormal_hair_cycle0.69419986
121MP0002272_abnormal_nervous_system0.68378836
122MP0000716_abnormal_immune_system0.67853631
123MP0008875_abnormal_xenobiotic_pharmacok0.67612371
124MP0001764_abnormal_homeostasis0.66988803
125MP0005621_abnormal_cell_physiology0.66884653
126MP0005671_abnormal_response_to0.66676950
127MP0000516_abnormal_urinary_system0.66306841
128MP0005367_renal/urinary_system_phenotyp0.66306841
129MP0001853_heart_inflammation0.65848476
130MP0002161_abnormal_fertility/fecundity0.65547666
131MP0002735_abnormal_chemical_nociception0.64988878
132MP0005636_abnormal_mineral_homeostasis0.64889571
133MP0002163_abnormal_gland_morphology0.64850253
134MP0005174_abnormal_tail_pigmentation0.64831189
135MP0004147_increased_porphyrin_level0.64722390
136MP0002282_abnormal_trachea_morphology0.62843249
137MP0003122_maternal_imprinting0.62060172
138MP0004084_abnormal_cardiac_muscle0.61744779
139MP0010386_abnormal_urinary_bladder0.61705610
140MP0009745_abnormal_behavioral_response0.59982088
141MP0002095_abnormal_skin_pigmentation0.57971606
142MP0002938_white_spotting0.56998007
143MP0000858_altered_metastatic_potential0.55003852
144MP0004133_heterotaxia0.53276507
145MP0002009_preneoplasia0.52699995
146MP0002420_abnormal_adaptive_immunity0.51687070
147MP0001286_abnormal_eye_development0.51314402
148MP0002127_abnormal_cardiovascular_syste0.50592924
149MP0001819_abnormal_immune_cell0.50193730
150MP0001915_intracranial_hemorrhage0.48899049
151MP0003646_muscle_fatigue0.47335610
152MP0001835_abnormal_antigen_presentation0.47329773

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.38936034
2Increased hepatocellular lipid droplets (HP:0006565)4.20774468
3Acute necrotizing encephalopathy (HP:0006965)4.11816712
4Breast hypoplasia (HP:0003187)4.10702623
5Lipid accumulation in hepatocytes (HP:0006561)4.03682804
6Mitochondrial inheritance (HP:0001427)3.94108644
7Aplastic anemia (HP:0001915)3.73943141
8Progressive macrocephaly (HP:0004481)3.70475577
9Increased CSF lactate (HP:0002490)3.66956310
10Patellar aplasia (HP:0006443)3.66459689
11Chromsome breakage (HP:0040012)3.63138969
12Acute encephalopathy (HP:0006846)3.62706632
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60197187
14Abnormal mitochondria in muscle tissue (HP:0008316)3.58118083
15Oral leukoplakia (HP:0002745)3.53943401
16Methylmalonic acidemia (HP:0002912)3.49887652
17Carpal bone hypoplasia (HP:0001498)3.43248923
18Aplasia/Hypoplasia of the patella (HP:0006498)3.42231469
19Meckel diverticulum (HP:0002245)3.38237305
20Degeneration of anterior horn cells (HP:0002398)3.28884965
21Abnormality of the anterior horn cell (HP:0006802)3.28884965
22Reticulocytopenia (HP:0001896)3.28519886
23Hepatocellular necrosis (HP:0001404)3.24312737
24Colon cancer (HP:0003003)3.22715025
25Abnormality of the preputium (HP:0100587)3.22402582
26Renal Fanconi syndrome (HP:0001994)3.21923646
27Abnormality of the ileum (HP:0001549)3.16350808
28Hepatic necrosis (HP:0002605)3.12382308
29Abnormality of chromosome stability (HP:0003220)3.10231036
30Rough bone trabeculation (HP:0100670)3.02807027
31Cerebral hypomyelination (HP:0006808)3.00875713
32Abnormal lung lobation (HP:0002101)2.98073933
33Abnormal number of erythroid precursors (HP:0012131)2.91521227
34Abnormality of cells of the erythroid lineage (HP:0012130)2.85583401
35Muscle fiber atrophy (HP:0100295)2.83505629
36Exertional dyspnea (HP:0002875)2.83432324
37Supernumerary spleens (HP:0009799)2.82163296
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.82062021
39Myelodysplasia (HP:0002863)2.81584867
40Type 2 muscle fiber atrophy (HP:0003554)2.81367960
41Hyperglycinemia (HP:0002154)2.80484934
42Duodenal stenosis (HP:0100867)2.80064800
43Small intestinal stenosis (HP:0012848)2.80064800
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78477501
45Abnormality of alanine metabolism (HP:0010916)2.78477501
46Hyperalaninemia (HP:0003348)2.78477501
47Methylmalonic aciduria (HP:0012120)2.78181511
48True hermaphroditism (HP:0010459)2.76714214
49Cerebral edema (HP:0002181)2.76691968
50Increased intramyocellular lipid droplets (HP:0012240)2.74019245
51Microretrognathia (HP:0000308)2.70092516
52Medulloblastoma (HP:0002885)2.69879596
53Abnormal spermatogenesis (HP:0008669)2.69082387
54Bone marrow hypocellularity (HP:0005528)2.68652479
55Absent thumb (HP:0009777)2.67631610
56Premature graying of hair (HP:0002216)2.65846859
57Premature ovarian failure (HP:0008209)2.60995986
58Glycosuria (HP:0003076)2.54514295
59Abnormality of urine glucose concentration (HP:0011016)2.54514295
60Nephronophthisis (HP:0000090)2.47044343
61Congenital, generalized hypertrichosis (HP:0004540)2.46741351
62Lactic acidosis (HP:0003128)2.44143461
6311 pairs of ribs (HP:0000878)2.43625831
64Molar tooth sign on MRI (HP:0002419)2.43348656
65Abnormality of midbrain morphology (HP:0002418)2.43348656
66Type I transferrin isoform profile (HP:0003642)2.41172482
67Medial flaring of the eyebrow (HP:0010747)2.40071113
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38359425
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36987624
70Absent radius (HP:0003974)2.35245198
71Impulsivity (HP:0100710)2.33748482
72Agnosia (HP:0010524)2.33413332
73Cellular immunodeficiency (HP:0005374)2.33226589
74Selective tooth agenesis (HP:0001592)2.33183373
75Increased muscle lipid content (HP:0009058)2.30299719
76Abnormal glycosylation (HP:0012345)2.29490313
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29490313
78Abnormal protein N-linked glycosylation (HP:0012347)2.29490313
79Abnormal protein glycosylation (HP:0012346)2.29490313
80Respiratory difficulties (HP:0002880)2.28881791
81Abnormality of DNA repair (HP:0003254)2.28345646
82Abnormality of renal resorption (HP:0011038)2.26143528
83Secondary amenorrhea (HP:0000869)2.25904157
84Sloping forehead (HP:0000340)2.25269842
85Lethargy (HP:0001254)2.24272980
86Neoplasm of the pancreas (HP:0002894)2.23250530
87Horseshoe kidney (HP:0000085)2.21772817
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21326508
89Nephroblastoma (Wilms tumor) (HP:0002667)2.21184221
90Optic disc pallor (HP:0000543)2.20932627
91Abnormality of the duodenum (HP:0002246)2.20894556
92Entropion (HP:0000621)2.19856333
93Abnormality of the labia minora (HP:0012880)2.19125787
94Abnormality of vitamin B metabolism (HP:0004340)2.18401603
95Abnormality of serum amino acid levels (HP:0003112)2.17707617
96Aplasia involving forearm bones (HP:0009822)2.16030355
97Absent forearm bone (HP:0003953)2.16030355
98Abnormality of the vitamin B12 metabolism (HP:0004341)2.15971495
99Respiratory failure (HP:0002878)2.15346426
100Abnormal trabecular bone morphology (HP:0100671)2.14495950
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.13591430
102Cleft eyelid (HP:0000625)2.12255863
103Triphalangeal thumb (HP:0001199)2.10466004
104Pendular nystagmus (HP:0012043)2.08410988
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07662003
106Abolished electroretinogram (ERG) (HP:0000550)2.05327133
107Embryonal renal neoplasm (HP:0011794)2.05217037
108Thrombocytosis (HP:0001894)2.05049836
109Rhabdomyosarcoma (HP:0002859)2.02086210
110B lymphocytopenia (HP:0010976)2.01778667
111Macrocytic anemia (HP:0001972)2.01730732
112Abnormality of methionine metabolism (HP:0010901)2.00716846
113Aplasia/Hypoplasia of the sternum (HP:0006714)2.00147835
114Pancytopenia (HP:0001876)1.99128137
115Gonadotropin excess (HP:0000837)1.99063846
116Ectopic kidney (HP:0000086)1.98681386
117Facial cleft (HP:0002006)1.97404343
118Sparse eyelashes (HP:0000653)1.97047981
119Increased serum pyruvate (HP:0003542)1.96707196
120Abnormality of glycolysis (HP:0004366)1.96707196
121Capillary hemangiomas (HP:0005306)1.96116492
122Tracheoesophageal fistula (HP:0002575)1.95818739
1233-Methylglutaconic aciduria (HP:0003535)1.95717692
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95069473
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94744362
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94744362
127Abnormality of B cell number (HP:0010975)1.94627041
128Abnormality of the renal medulla (HP:0100957)1.94167436
129Clubbing of toes (HP:0100760)1.93756383
130Leukodystrophy (HP:0002415)1.92581197
131Exercise intolerance (HP:0003546)1.91846038
132Poikiloderma (HP:0001029)1.91363344
133Congenital primary aphakia (HP:0007707)1.90704340
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89943152
135Microvesicular hepatic steatosis (HP:0001414)1.89822892
136Male pseudohermaphroditism (HP:0000037)1.89612078
137Increased serum lactate (HP:0002151)1.89039256
138Septo-optic dysplasia (HP:0100842)1.88222090
139IgM deficiency (HP:0002850)1.88030512
140Renal cortical cysts (HP:0000803)1.87623327
141Lymphoma (HP:0002665)1.87300817
142Reduced antithrombin III activity (HP:0001976)1.86740165
143Abnormality of glycine metabolism (HP:0010895)1.85850403
144Abnormality of serine family amino acid metabolism (HP:0010894)1.85850403
145Dicarboxylic aciduria (HP:0003215)1.85395062
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85395062
147Type II lissencephaly (HP:0007260)1.84049065
148CNS hypomyelination (HP:0003429)1.83819583
149Progressive inability to walk (HP:0002505)1.83095510
150Pancreatic cysts (HP:0001737)1.83062572
151Pallor (HP:0000980)1.82354322
152Hypoglycemic coma (HP:0001325)1.82347481
153Hypoglycemic seizures (HP:0002173)1.81271967
154Volvulus (HP:0002580)1.81263713
155Squamous cell carcinoma (HP:0002860)1.80437520
156Basal cell carcinoma (HP:0002671)1.79365438
157Ependymoma (HP:0002888)1.79060604
158Aplasia/hypoplasia of the uterus (HP:0008684)1.78303507
159Stenosis of the external auditory canal (HP:0000402)1.78094029
160Retinal dysplasia (HP:0007973)1.77761657
161CNS demyelination (HP:0007305)1.77627479
162Azoospermia (HP:0000027)1.76810188
163Slender long bone (HP:0003100)1.76229971
164Nephrogenic diabetes insipidus (HP:0009806)1.76165159
165Gait imbalance (HP:0002141)1.76094976
166Hypoplasia of the pons (HP:0012110)1.75300630
167Abnormal biliary tract physiology (HP:0012439)1.75136102
168Bile duct proliferation (HP:0001408)1.75136102
169Pancreatic fibrosis (HP:0100732)1.75083306
170Neoplasm of the colon (HP:0100273)1.74672619
171Irregular epiphyses (HP:0010582)1.72928791
172Median cleft lip (HP:0000161)1.71081995
173Genital tract atresia (HP:0001827)1.70660376
174Pancreatic islet-cell hyperplasia (HP:0004510)1.70036669
175Stomatitis (HP:0010280)1.69247701
176Severe combined immunodeficiency (HP:0004430)1.68175535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.35591677
2WEE14.34451324
3CDC73.35635946
4EIF2AK13.33576007
5BRSK23.03436958
6ACVR1B2.91071257
7PLK42.86769546
8SRPK12.83399106
9TRIM282.56036493
10VRK22.44131371
11BCKDK2.39038957
12TSSK62.36784819
13NEK22.32763116
14MAP4K22.26844267
15CCNB12.25986892
16EIF2AK32.25930431
17STK162.25671109
18WNK32.12496280
19FRK2.12400963
20NEK12.10583425
21PLK12.01599862
22MKNK11.98013647
23BRSK11.95047177
24VRK11.94748316
25PLK31.88250378
26TTK1.78157280
27TAOK31.75886693
28MKNK21.69788754
29AURKB1.62662870
30DYRK31.58842135
31GRK11.51974025
32CDK191.50708393
33NME21.49146840
34CDK71.43453062
35RPS6KA41.43076711
36CDK81.41162261
37ATR1.39632226
38CHEK21.38142103
39PINK11.35326292
40AURKA1.28134817
41STK38L1.23367152
42INSRR1.22846549
43PLK21.22372460
44TESK21.22192474
45OXSR11.21052080
46ADRBK21.19313988
47STK391.16899471
48ZAK1.16388145
49TGFBR11.14865308
50TNIK1.10448849
51PASK1.10348748
52BCR1.06778080
53CHEK11.01865712
54WNK41.01792764
55TAF10.98794940
56RPS6KB20.98642507
57AKT30.98431321
58BRAF0.97426070
59MAPKAPK30.94779032
60CDK40.94371416
61CSNK1G10.92230529
62PIM20.90605652
63EIF2AK20.88905021
64TAOK20.87910045
65CSNK1G20.85149728
66STK240.83990802
67CSNK1G30.83821647
68PDK30.82807637
69PDK40.82807637
70STK40.82490274
71CASK0.79999629
72OBSCN0.78555094
73NUAK10.77741098
74MAP3K80.77504089
75MAPK130.77244700
76MAP3K110.76194022
77PNCK0.75596832
78PIM10.73377536
79BRD40.71702878
80CSNK2A10.71481001
81DYRK20.70329278
82ATM0.69423156
83MAP4K10.66351787
84CDK20.65215417
85KDR0.63558088
86MINK10.62457213
87STK100.62344012
88TESK10.61988210
89MAP2K70.61959086
90PAK40.61957102
91MAP2K30.61473566
92MELK0.60326613
93DAPK10.59771332
94PRKCE0.58692721
95TLK10.57891897
96CSNK2A20.57495166
97PBK0.57340857
98PRKCG0.56362041
99EPHA20.53997394
100NLK0.53580941
101TXK0.53094550
102CDK10.50986498
103CSNK1A1L0.50985112
104RPS6KA50.50201632
105PAK10.49774887
106LIMK10.49057016
107MAP3K30.48739312
108TEC0.47884137
109PRKCI0.47702142
110STK30.47095349
111MUSK0.47082046
112MAP3K40.46915599
113TIE10.44877365
114IRAK40.44319818
115MYLK0.43013684
116PRKCQ0.42522017
117BMPR20.41911058
118MARK30.39895409
119ILK0.38994550
120NEK90.38603989
121MAP3K120.37121223
122FGFR20.36512572
123GRK70.35733303
124NME10.34816347
125ZAP700.34126255
126PDK20.32852196
127YES10.31620848
128MAP3K50.31266694
129CSNK1A10.30790181
130BTK0.29068944
131IKBKB0.28777107
132CDK120.27053511
133PAK30.27020224
134MST40.26677015
135LATS20.26254385
136BMPR1B0.26250527
137IGF1R0.26220962
138CLK10.25513794
139CDK30.25049028
140RPS6KA60.24492181
141ERBB30.23669617
142AKT20.23095215
143SIK30.22811109

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55912263
2Proteasome_Homo sapiens_hsa030504.15857523
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01527233
4Mismatch repair_Homo sapiens_hsa034304.00127391
5RNA polymerase_Homo sapiens_hsa030203.95906085
6Spliceosome_Homo sapiens_hsa030403.21565005
7Base excision repair_Homo sapiens_hsa034103.14621458
8RNA transport_Homo sapiens_hsa030133.10190865
9Nucleotide excision repair_Homo sapiens_hsa034203.06453663
10Ribosome_Homo sapiens_hsa030103.05422993
11Homologous recombination_Homo sapiens_hsa034403.05120149
12Cell cycle_Homo sapiens_hsa041102.81225110
13Pyrimidine metabolism_Homo sapiens_hsa002402.64355563
14Basal transcription factors_Homo sapiens_hsa030222.61377394
15Fanconi anemia pathway_Homo sapiens_hsa034602.34147427
16RNA degradation_Homo sapiens_hsa030182.09786382
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09585241
18Propanoate metabolism_Homo sapiens_hsa006401.97638526
19Non-homologous end-joining_Homo sapiens_hsa034501.97078310
20One carbon pool by folate_Homo sapiens_hsa006701.92384809
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90312620
22Alzheimers disease_Homo sapiens_hsa050101.86182622
23mRNA surveillance pathway_Homo sapiens_hsa030151.69922183
24p53 signaling pathway_Homo sapiens_hsa041151.65894219
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65652197
26Purine metabolism_Homo sapiens_hsa002301.60336804
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51296652
28Fatty acid elongation_Homo sapiens_hsa000621.42929836
29Butanoate metabolism_Homo sapiens_hsa006501.34207870
30Epstein-Barr virus infection_Homo sapiens_hsa051691.30201074
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25073319
32Cardiac muscle contraction_Homo sapiens_hsa042601.21584184
33Vitamin B6 metabolism_Homo sapiens_hsa007501.17463503
34Protein export_Homo sapiens_hsa030601.15441588
35Peroxisome_Homo sapiens_hsa041461.08187397
36Phototransduction_Homo sapiens_hsa047441.06010496
37Oocyte meiosis_Homo sapiens_hsa041141.04874455
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02384545
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01449770
40Herpes simplex infection_Homo sapiens_hsa051680.97171638
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.90510373
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87828854
43Collecting duct acid secretion_Homo sapiens_hsa049660.86817478
44Huntingtons disease_Homo sapiens_hsa050160.84910762
45Pentose phosphate pathway_Homo sapiens_hsa000300.84514204
46Pyruvate metabolism_Homo sapiens_hsa006200.81734461
47Nitrogen metabolism_Homo sapiens_hsa009100.79680611
48Folate biosynthesis_Homo sapiens_hsa007900.77391321
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.76221768
50Antigen processing and presentation_Homo sapiens_hsa046120.74540267
51Chemical carcinogenesis_Homo sapiens_hsa052040.74366353
52Tryptophan metabolism_Homo sapiens_hsa003800.74330547
53Parkinsons disease_Homo sapiens_hsa050120.71468663
54Linoleic acid metabolism_Homo sapiens_hsa005910.70843647
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69570457
56Regulation of autophagy_Homo sapiens_hsa041400.65923608
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65320007
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65032348
59Primary immunodeficiency_Homo sapiens_hsa053400.64489951
60HTLV-I infection_Homo sapiens_hsa051660.63999255
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63597619
62Steroid biosynthesis_Homo sapiens_hsa001000.63425060
63Biosynthesis of amino acids_Homo sapiens_hsa012300.63346123
64Viral carcinogenesis_Homo sapiens_hsa052030.62925387
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61042772
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60428492
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.59790926
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59597941
69Retinol metabolism_Homo sapiens_hsa008300.59572175
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57666975
71Sulfur metabolism_Homo sapiens_hsa009200.57344550
72Caffeine metabolism_Homo sapiens_hsa002320.57225292
73Type I diabetes mellitus_Homo sapiens_hsa049400.56887666
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.56766493
75Thyroid cancer_Homo sapiens_hsa052160.56351019
76Ether lipid metabolism_Homo sapiens_hsa005650.54308977
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52753193
78Systemic lupus erythematosus_Homo sapiens_hsa053220.51800258
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51156381
80Olfactory transduction_Homo sapiens_hsa047400.50247299
81Legionellosis_Homo sapiens_hsa051340.49462701
82Fructose and mannose metabolism_Homo sapiens_hsa000510.47238680
83Oxidative phosphorylation_Homo sapiens_hsa001900.45967083
84Fatty acid degradation_Homo sapiens_hsa000710.45355955
85Glutathione metabolism_Homo sapiens_hsa004800.45190829
86Nicotine addiction_Homo sapiens_hsa050330.44178201
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43536013
88Fatty acid metabolism_Homo sapiens_hsa012120.40326854
89Measles_Homo sapiens_hsa051620.39951898
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39171464
91Vitamin digestion and absorption_Homo sapiens_hsa049770.39084015
92Galactose metabolism_Homo sapiens_hsa000520.38961905
93Autoimmune thyroid disease_Homo sapiens_hsa053200.38321003
94Rheumatoid arthritis_Homo sapiens_hsa053230.37861433
95Arachidonic acid metabolism_Homo sapiens_hsa005900.37452910
96Carbon metabolism_Homo sapiens_hsa012000.36765527
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36221915
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.34118104
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.33892895
100Apoptosis_Homo sapiens_hsa042100.33739420
101TGF-beta signaling pathway_Homo sapiens_hsa043500.33681607
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32754248
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32699967
104Selenocompound metabolism_Homo sapiens_hsa004500.32688403
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31353464
106N-Glycan biosynthesis_Homo sapiens_hsa005100.29932616
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.29396369
108Metabolic pathways_Homo sapiens_hsa011000.28573585
109MicroRNAs in cancer_Homo sapiens_hsa052060.27876366
110Influenza A_Homo sapiens_hsa051640.27604795
111Small cell lung cancer_Homo sapiens_hsa052220.26457138
112Shigellosis_Homo sapiens_hsa051310.26418109
113Colorectal cancer_Homo sapiens_hsa052100.26220705
114beta-Alanine metabolism_Homo sapiens_hsa004100.25860134
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24889591
116Hepatitis B_Homo sapiens_hsa051610.24343926
117Sulfur relay system_Homo sapiens_hsa041220.24271443
118Hippo signaling pathway_Homo sapiens_hsa043900.23840049
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23495114
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22057368
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.21945000
122Allograft rejection_Homo sapiens_hsa053300.21413133
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21404824
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21022368
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18445772
126Circadian rhythm_Homo sapiens_hsa047100.16847338
127HIF-1 signaling pathway_Homo sapiens_hsa040660.16657306
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15478058
129Graft-versus-host disease_Homo sapiens_hsa053320.13726682
130Pathways in cancer_Homo sapiens_hsa052000.13681596
131Hematopoietic cell lineage_Homo sapiens_hsa046400.12626486
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11491708
133Basal cell carcinoma_Homo sapiens_hsa052170.11243088
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10977615
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10565635
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10436009
137Alcoholism_Homo sapiens_hsa050340.09623126
138FoxO signaling pathway_Homo sapiens_hsa040680.08740380
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08354258
140Asthma_Homo sapiens_hsa053100.08145641
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06892420
142Acute myeloid leukemia_Homo sapiens_hsa052210.05599794

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