MED30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.14552204
2ribosomal small subunit assembly (GO:0000028)4.92599200
3viral transcription (GO:0019083)4.68417299
4translational termination (GO:0006415)4.59527598
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37889479
6ribosomal small subunit biogenesis (GO:0042274)4.34151387
7DNA strand elongation involved in DNA replication (GO:0006271)4.32854542
8chaperone-mediated protein transport (GO:0072321)4.29159572
9telomere maintenance via semi-conservative replication (GO:0032201)4.28657030
10CENP-A containing nucleosome assembly (GO:0034080)4.25164025
11chromatin remodeling at centromere (GO:0031055)4.22906355
12translational elongation (GO:0006414)4.19149872
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14911223
14purine nucleotide salvage (GO:0032261)4.13495720
15DNA strand elongation (GO:0022616)4.06756167
16mitotic metaphase plate congression (GO:0007080)4.05265018
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97648683
18DNA replication initiation (GO:0006270)3.94587527
19folic acid-containing compound biosynthetic process (GO:0009396)3.93603453
20telomere maintenance via recombination (GO:0000722)3.91313606
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.89627298
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.89627298
23cotranslational protein targeting to membrane (GO:0006613)3.89497751
24DNA replication-independent nucleosome assembly (GO:0006336)3.87876180
25DNA replication-independent nucleosome organization (GO:0034724)3.87876180
26ATP synthesis coupled proton transport (GO:0015986)3.87868178
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87868178
28protein targeting to ER (GO:0045047)3.87536668
29maturation of SSU-rRNA (GO:0030490)3.87375751
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.85985773
31deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.83950459
32translational initiation (GO:0006413)3.81138634
33DNA replication-dependent nucleosome organization (GO:0034723)3.80278095
34DNA replication-dependent nucleosome assembly (GO:0006335)3.80278095
35mitotic recombination (GO:0006312)3.72804326
36viral life cycle (GO:0019058)3.70005658
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69888719
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69882142
39protein complex biogenesis (GO:0070271)3.67166992
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67062089
41protein localization to endoplasmic reticulum (GO:0070972)3.66638748
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65474700
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.65474700
44NADH dehydrogenase complex assembly (GO:0010257)3.65474700
45DNA replication checkpoint (GO:0000076)3.61928664
46protein K6-linked ubiquitination (GO:0085020)3.60919327
47mitotic sister chromatid segregation (GO:0000070)3.59358185
48cellular protein complex disassembly (GO:0043624)3.58588477
49protein localization to chromosome, centromeric region (GO:0071459)3.57066503
50ribosomal large subunit biogenesis (GO:0042273)3.53236046
51mitochondrial respiratory chain complex assembly (GO:0033108)3.51112913
52DNA unwinding involved in DNA replication (GO:0006268)3.48931089
53metaphase plate congression (GO:0051310)3.47316194
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.47097792
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.43866557
56maturation of 5.8S rRNA (GO:0000460)3.42292948
57purine-containing compound salvage (GO:0043101)3.42003839
58deoxyribonucleotide catabolic process (GO:0009264)3.41423363
59deoxyribose phosphate catabolic process (GO:0046386)3.39114942
60proteasome assembly (GO:0043248)3.37601292
61protein localization to kinetochore (GO:0034501)3.37561569
62establishment of chromosome localization (GO:0051303)3.37070542
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37047412
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36090721
65protein complex localization (GO:0031503)3.35352179
66attachment of spindle microtubules to kinetochore (GO:0008608)3.33931585
67kinetochore organization (GO:0051383)3.32440426
68purine deoxyribonucleotide catabolic process (GO:0009155)3.32244223
69mitotic nuclear envelope disassembly (GO:0007077)3.31340541
70meiotic chromosome segregation (GO:0045132)3.30726084
71histone exchange (GO:0043486)3.29590094
72telomere maintenance via telomere lengthening (GO:0010833)3.28399939
73mitotic chromosome condensation (GO:0007076)3.27958932
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26825188
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24732965
76kinetochore assembly (GO:0051382)3.22759284
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21764295
78rRNA modification (GO:0000154)3.21194140
79protein complex disassembly (GO:0043241)3.19449548
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18221005
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18221005
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18221005
83pyrimidine nucleotide catabolic process (GO:0006244)3.17955177
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17445730
85DNA damage response, signal transduction resulting in transcription (GO:0042772)3.16258598
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15692722
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15692722
88base-excision repair, AP site formation (GO:0006285)3.15540504
89ribonucleoprotein complex biogenesis (GO:0022613)3.15332349
902-deoxyribonucleotide metabolic process (GO:0009394)3.14139319
91nucleotide salvage (GO:0043173)3.12862738
92negative regulation of B cell apoptotic process (GO:0002903)3.11174892
93respiratory electron transport chain (GO:0022904)3.10618253
94transcription-coupled nucleotide-excision repair (GO:0006283)3.08976269
95deoxyribose phosphate metabolic process (GO:0019692)3.08826124
96rRNA processing (GO:0006364)3.08808727
97membrane disassembly (GO:0030397)3.07653185
98nuclear envelope disassembly (GO:0051081)3.07653185
99sister chromatid segregation (GO:0000819)3.07517622
100regulation of cellular amino acid metabolic process (GO:0006521)3.07382079
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07375078
102regulation of exit from mitosis (GO:0007096)3.06406070
103DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.06371163
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06101447
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.05725443
106electron transport chain (GO:0022900)3.05466369
107protein-cofactor linkage (GO:0018065)3.04733586
108signal transduction involved in DNA damage checkpoint (GO:0072422)3.04616921
109signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04616921
110signal transduction involved in cell cycle checkpoint (GO:0072395)3.04108381
111chromatin assembly or disassembly (GO:0006333)3.03547063
112establishment of integrated proviral latency (GO:0075713)3.03317135
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02995215
114macromolecular complex disassembly (GO:0032984)3.02817877
115regulation of double-strand break repair via homologous recombination (GO:0010569)3.02288656
116pseudouridine synthesis (GO:0001522)3.02202168
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99669129
118translation (GO:0006412)2.98500281
119rRNA metabolic process (GO:0016072)2.97272493
120regulation of histone H3-K27 methylation (GO:0061085)2.95727930
121mRNA catabolic process (GO:0006402)2.94235358
122protein targeting to mitochondrion (GO:0006626)2.93673919
123adenosine metabolic process (GO:0046085)2.93277738
124protein K11-linked ubiquitination (GO:0070979)2.92344279
125mannosylation (GO:0097502)2.91125048
126histone mRNA metabolic process (GO:0008334)2.91106434
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91104689
128spindle checkpoint (GO:0031577)2.90986362
129spliceosomal snRNP assembly (GO:0000387)2.90037213
130deoxyribose phosphate biosynthetic process (GO:0046385)2.89851193
1312-deoxyribonucleotide biosynthetic process (GO:0009265)2.89851193
132regulation of RIG-I signaling pathway (GO:0039535)2.89181550
133positive regulation of ligase activity (GO:0051351)2.89056895
134cullin deneddylation (GO:0010388)2.87375499
135purine deoxyribonucleotide metabolic process (GO:0009151)2.87349903
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86865203
137DNA ligation (GO:0006266)2.85760235
138negative regulation of ligase activity (GO:0051352)2.84562866
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84562866
140RNA catabolic process (GO:0006401)2.83744000
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82506648
142negative regulation of sister chromatid segregation (GO:0033046)2.82506648
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.82506648
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82506648
145negative regulation of chromosome segregation (GO:0051985)2.81055211
146iron-sulfur cluster assembly (GO:0016226)2.80708554
147metallo-sulfur cluster assembly (GO:0031163)2.80708554
148pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80163805
149protein deneddylation (GO:0000338)2.79777809
150regulation of chromosome segregation (GO:0051983)2.79297638
151pteridine-containing compound biosynthetic process (GO:0042559)2.79167427
152purine nucleobase biosynthetic process (GO:0009113)2.78377105
153nucleoside salvage (GO:0043174)2.78048593
154deoxyribonucleotide metabolic process (GO:0009262)2.77802247
155regulation of mitochondrial translation (GO:0070129)2.77440727
156establishment of viral latency (GO:0019043)2.73257897
157transcription elongation from RNA polymerase III promoter (GO:0006385)2.72953630
158termination of RNA polymerase III transcription (GO:0006386)2.72953630
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72940706
160regulation of mitotic spindle checkpoint (GO:1903504)2.72940706
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72356977
162DNA double-strand break processing (GO:0000729)2.70712202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.22617272
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.32086851
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24322471
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81545871
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67066279
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62309507
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.19819088
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19112633
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93199225
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82168930
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75414214
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75409272
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69261399
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.67898167
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.66181956
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64112949
17XRN2_22483619_ChIP-Seq_HELA_Human2.39981899
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33808170
19AR_21909140_ChIP-Seq_LNCAP_Human2.32556583
20* VDR_23849224_ChIP-Seq_CD4+_Human2.31423351
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30321034
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20327122
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13389811
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11847636
25DCP1A_22483619_ChIP-Seq_HELA_Human2.10741387
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10220758
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.99715568
28GABP_19822575_ChIP-Seq_HepG2_Human1.97600115
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96784588
30TTF2_22483619_ChIP-Seq_HELA_Human1.89919501
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89874085
32FOXP3_21729870_ChIP-Seq_TREG_Human1.89422004
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86478099
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85482103
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80769262
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78974546
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77478204
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75989594
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74417325
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73610848
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68985610
42MYC_22102868_ChIP-Seq_BL_Human1.68822996
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61407711
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56867111
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56648923
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54354441
47IRF1_19129219_ChIP-ChIP_H3396_Human1.53091053
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50152080
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46815231
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45451392
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45265642
52MYC_18940864_ChIP-ChIP_HL60_Human1.45216468
53ELK1_19687146_ChIP-ChIP_HELA_Human1.44085415
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.44007303
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38946527
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36987339
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.36121733
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35919184
59KDM5A_27292631_Chip-Seq_BREAST_Human1.35686551
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35608373
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.35281607
62VDR_21846776_ChIP-Seq_THP-1_Human1.32504908
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32134099
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.30787833
65CIITA_25753668_ChIP-Seq_RAJI_Human1.30011750
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29722837
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28856994
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28754133
69ZNF274_21170338_ChIP-Seq_K562_Hela1.27492755
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24831518
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.21043318
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19812498
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19460243
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18404587
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17985083
76IGF1R_20145208_ChIP-Seq_DFB_Human1.15151209
77* SPI1_23547873_ChIP-Seq_NB4_Human1.13365577
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09341942
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04169491
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03327593
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01597353
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00533244
83TFEB_21752829_ChIP-Seq_HELA_Human1.00383875
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00279109
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97861747
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97648240
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96834269
88EWS_26573619_Chip-Seq_HEK293_Human0.96783416
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.94382832
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91915989
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91788761
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91119708
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90732567
94GATA3_26560356_Chip-Seq_TH2_Human0.90089592
95UTX_26944678_Chip-Seq_JUKART_Human0.89491208
96TP53_22573176_ChIP-Seq_HFKS_Human0.89149753
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88298640
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.88203899
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87978136
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85008428
101MYB_26560356_Chip-Seq_TH2_Human0.84965316
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83595951
103VDR_22108803_ChIP-Seq_LS180_Human0.83345789
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83158742
105PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83106410
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82356925
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82332886
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82316536
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82051199
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80520634
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79760827
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79211433
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79058216
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78926215
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78902398
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78053320
117ERG_20517297_ChIP-Seq_VCAP_Human0.78044399
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77027530
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76811216
120IRF8_21731497_ChIP-ChIP_J774_Mouse0.75254215
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73291958
122FUS_26573619_Chip-Seq_HEK293_Human0.73013305
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.69805651
124MYB_26560356_Chip-Seq_TH1_Human0.66510151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.09716160
2MP0004957_abnormal_blastocyst_morpholog4.54067947
3MP0003111_abnormal_nucleus_morphology4.01997241
4MP0010094_abnormal_chromosome_stability3.98880169
5MP0003077_abnormal_cell_cycle3.80560474
6MP0008932_abnormal_embryonic_tissue2.82436509
7MP0003718_maternal_effect2.69166839
8MP0002653_abnormal_ependyma_morphology2.65181776
9MP0002102_abnormal_ear_morphology2.57998562
10MP0000490_abnormal_crypts_of2.35953714
11MP0008058_abnormal_DNA_repair2.25400385
12MP0008007_abnormal_cellular_replicative2.23369301
13MP0003646_muscle_fatigue2.20143548
14MP0008057_abnormal_DNA_replication2.18610640
15MP0003123_paternal_imprinting2.16948672
16MP0003787_abnormal_imprinting2.02937114
17MP0009697_abnormal_copulation1.98268971
18MP0002396_abnormal_hematopoietic_system1.93522335
19MP0002148_abnormal_hypersensitivity_rea1.92608217
20MP0005084_abnormal_gallbladder_morpholo1.90610078
21MP0000350_abnormal_cell_proliferation1.90071167
22MP0005075_abnormal_melanosome_morpholog1.89052061
23MP0010352_gastrointestinal_tract_polyps1.88469741
24MP0001730_embryonic_growth_arrest1.86281813
25MP0006292_abnormal_olfactory_placode1.86135796
26MP0003763_abnormal_thymus_physiology1.85663653
27MP0008995_early_reproductive_senescence1.76901685
28MP0000372_irregular_coat_pigmentation1.76172275
29MP0001764_abnormal_homeostasis1.73894930
30MP0009333_abnormal_splenocyte_physiolog1.71500097
31MP0002019_abnormal_tumor_incidence1.67973356
32MP0003724_increased_susceptibility_to1.64972251
33MP0008877_abnormal_DNA_methylation1.61950525
34MP0005451_abnormal_body_composition1.59767715
35MP0001697_abnormal_embryo_size1.57082541
36MP0009764_decreased_sensitivity_to1.54330307
37MP0006072_abnormal_retinal_apoptosis1.53785536
38MP0002398_abnormal_bone_marrow1.48237054
39MP0005410_abnormal_fertilization1.43916119
40MP0002138_abnormal_hepatobiliary_system1.43424543
41MP0000313_abnormal_cell_death1.40871218
42MP0003186_abnormal_redox_activity1.38108649
43MP0003786_premature_aging1.38079176
44MP0000703_abnormal_thymus_morphology1.37738824
45MP0002277_abnormal_respiratory_mucosa1.36576508
46MP0001853_heart_inflammation1.36567911
47MP0002163_abnormal_gland_morphology1.36061656
48MP0006054_spinal_hemorrhage1.35401569
49MP0002085_abnormal_embryonic_tissue1.33854813
50MP0004808_abnormal_hematopoietic_stem1.31511388
51MP0001119_abnormal_female_reproductive1.31455873
52MP0002080_prenatal_lethality1.29450196
53MP0001905_abnormal_dopamine_level1.28776924
54MP0002722_abnormal_immune_system1.27548562
55MP0004147_increased_porphyrin_level1.26913125
56MP0000516_abnormal_urinary_system1.26893503
57MP0005367_renal/urinary_system_phenotyp1.26893503
58MP0000689_abnormal_spleen_morphology1.26004264
59MP0002210_abnormal_sex_determination1.24728332
60MP0000685_abnormal_immune_system1.21425911
61MP0000858_altered_metastatic_potential1.20719994
62MP0005646_abnormal_pituitary_gland1.17601896
63MP0000653_abnormal_sex_gland1.17483523
64MP0005671_abnormal_response_to1.15315692
65MP0001929_abnormal_gametogenesis1.15228591
66MP0000358_abnormal_cell_content/1.15033806
67MP0001672_abnormal_embryogenesis/_devel1.14741155
68MP0005380_embryogenesis_phenotype1.14741155
69MP0003656_abnormal_erythrocyte_physiolo1.13355205
70MP0005025_abnormal_response_to1.09645810
71MP0002095_abnormal_skin_pigmentation1.09475296
72MP0002429_abnormal_blood_cell1.09214586
73MP0003315_abnormal_perineum_morphology1.08843705
74MP0010234_abnormal_vibrissa_follicle1.08707086
75MP0005397_hematopoietic_system_phenotyp1.08495015
76MP0001545_abnormal_hematopoietic_system1.08495015
77MP0002419_abnormal_innate_immunity1.07412321
78MP0003806_abnormal_nucleotide_metabolis1.07052192
79MP0003436_decreased_susceptibility_to1.06809476
80MP0001145_abnormal_male_reproductive1.06624303
81MP0009765_abnormal_xenobiotic_induced1.04723129
82MP0010030_abnormal_orbit_morphology1.04097819
83MP0003567_abnormal_fetal_cardiomyocyte1.03555671
84MP0003221_abnormal_cardiomyocyte_apopto1.03187306
85MP0009278_abnormal_bone_marrow1.02939083
86MP0002084_abnormal_developmental_patter1.02809732
87MP0000716_abnormal_immune_system1.02411902
88MP0001915_intracranial_hemorrhage1.02226903
89MP0005253_abnormal_eye_physiology1.01967695
90MP0008872_abnormal_physiological_respon1.01401771
91MP0005387_immune_system_phenotype1.00404203
92MP0001790_abnormal_immune_system1.00404203
93MP0001529_abnormal_vocalization0.98586047
94MP0002006_tumorigenesis0.98520581
95MP0008873_increased_physiological_sensi0.98306445
96MP0003252_abnormal_bile_duct0.97970173
97MP0003699_abnormal_female_reproductive0.97398444
98MP0003984_embryonic_growth_retardation0.96322649
99MP0001800_abnormal_humoral_immune0.96079181
100MP0002877_abnormal_melanocyte_morpholog0.95554038
101MP0005408_hypopigmentation0.95401765
102MP0010307_abnormal_tumor_latency0.95170799
103MP0002420_abnormal_adaptive_immunity0.94855004
104MP0010155_abnormal_intestine_physiology0.93841617
105MP0002088_abnormal_embryonic_growth/wei0.93799202
106MP0002086_abnormal_extraembryonic_tissu0.92851521
107MP0001819_abnormal_immune_cell0.92713299
108MP0006036_abnormal_mitochondrial_physio0.90412619
109MP0002405_respiratory_system_inflammati0.90115061
110MP0009785_altered_susceptibility_to0.86314573
111MP0001873_stomach_inflammation0.85734068
112MP0009379_abnormal_foot_pigmentation0.85451258
113MP0002166_altered_tumor_susceptibility0.84204479
114MP0005395_other_phenotype0.83962244
115MP0005389_reproductive_system_phenotype0.82590895
116MP0002132_abnormal_respiratory_system0.82535878
117MP0000477_abnormal_intestine_morphology0.82026749
118MP0002452_abnormal_antigen_presenting0.81985199
119MP0004185_abnormal_adipocyte_glucose0.80584545
120MP0004142_abnormal_muscle_tone0.80399679
121MP0003698_abnormal_male_reproductive0.79907619
122MP0001835_abnormal_antigen_presentation0.79305753
123MP0005499_abnormal_olfactory_system0.79069376
124MP0005394_taste/olfaction_phenotype0.79069376
125MP0002723_abnormal_immune_serum0.78713361
126MP0001845_abnormal_inflammatory_respons0.77396512
127MP0002249_abnormal_larynx_morphology0.77036337
128MP0005266_abnormal_metabolism0.76398659
129MP0005384_cellular_phenotype0.75223914
130MP0002736_abnormal_nociception_after0.74955035
131MP0001727_abnormal_embryo_implantation0.74904688
132MP0001919_abnormal_reproductive_system0.74380896
133MP0008469_abnormal_protein_level0.74203745
134MP0005621_abnormal_cell_physiology0.73193031
135MP0003121_genomic_imprinting0.73085443
136MP0003937_abnormal_limbs/digits/tail_de0.72158492
137MP0005000_abnormal_immune_tolerance0.68403467
138MP0006035_abnormal_mitochondrial_morpho0.67955161
139MP0000613_abnormal_salivary_gland0.66784765
140MP0000465_gastrointestinal_hemorrhage0.62951824
141MP0008260_abnormal_autophagy0.62876400
142MP0008789_abnormal_olfactory_epithelium0.62284572
143MP0002160_abnormal_reproductive_system0.59963700

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.58172978
2Birth length less than 3rd percentile (HP:0003561)5.37281640
3Abnormal number of erythroid precursors (HP:0012131)5.32176775
4Reticulocytopenia (HP:0001896)4.94221982
5Aplastic anemia (HP:0001915)4.23346464
6Abnormal mitochondria in muscle tissue (HP:0008316)4.22573236
7Breast hypoplasia (HP:0003187)4.14035847
8Acute encephalopathy (HP:0006846)3.95079709
9Oral leukoplakia (HP:0002745)3.69249215
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56372079
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56372079
12Pallor (HP:0000980)3.54611211
13Progressive macrocephaly (HP:0004481)3.54577863
14Patellar aplasia (HP:0006443)3.43950937
15Macrocytic anemia (HP:0001972)3.43630320
16Microretrognathia (HP:0000308)3.39559025
17Aplasia/Hypoplasia of the patella (HP:0006498)3.34822311
18Muscle fiber atrophy (HP:0100295)3.34073853
19B lymphocytopenia (HP:0010976)3.27609853
20Degeneration of anterior horn cells (HP:0002398)3.24071127
21Abnormality of the anterior horn cell (HP:0006802)3.24071127
223-Methylglutaconic aciduria (HP:0003535)3.23647112
23Carpal bone hypoplasia (HP:0001498)3.18165364
24Abnormality of B cell number (HP:0010975)3.11017519
25Panhypogammaglobulinemia (HP:0003139)3.03525950
26Multiple enchondromatosis (HP:0005701)2.96951356
27Microvesicular hepatic steatosis (HP:0001414)2.90332379
28Cerebral edema (HP:0002181)2.88213044
29Lactic acidosis (HP:0003128)2.80437670
30Rough bone trabeculation (HP:0100670)2.79518732
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69962117
32Type 2 muscle fiber atrophy (HP:0003554)2.69356606
33Secondary amenorrhea (HP:0000869)2.68926585
34Cerebral hypomyelination (HP:0006808)2.62814885
35Renal Fanconi syndrome (HP:0001994)2.59054832
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58895909
37Increased muscle lipid content (HP:0009058)2.57515471
38Premature graying of hair (HP:0002216)2.55307489
39Pancreatic cysts (HP:0001737)2.53573081
40Premature ovarian failure (HP:0008209)2.49502943
41Chromsome breakage (HP:0040012)2.44492133
42Pulmonary fibrosis (HP:0002206)2.44482325
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43479365
44Abnormal protein N-linked glycosylation (HP:0012347)2.43479365
45Abnormal protein glycosylation (HP:0012346)2.43479365
46Abnormal glycosylation (HP:0012345)2.43479365
47Agammaglobulinemia (HP:0004432)2.40710636
48Absent thumb (HP:0009777)2.40046371
49Myelodysplasia (HP:0002863)2.39908146
50Exercise intolerance (HP:0003546)2.39793969
51Generalized aminoaciduria (HP:0002909)2.38595258
52Abnormality of the preputium (HP:0100587)2.36599478
53Hepatocellular necrosis (HP:0001404)2.34584004
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34530642
55Thrombocytosis (HP:0001894)2.33765827
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33395196
57Trismus (HP:0000211)2.32740798
58Cellular immunodeficiency (HP:0005374)2.32524352
59Abnormality of chromosome stability (HP:0003220)2.32175710
60Optic disc pallor (HP:0000543)2.27912001
61Constricted visual fields (HP:0001133)2.25884023
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25789084
63Abnormality of alanine metabolism (HP:0010916)2.25789084
64Hyperalaninemia (HP:0003348)2.25789084
65Basal cell carcinoma (HP:0002671)2.24652258
66Combined immunodeficiency (HP:0005387)2.23029446
67Exertional dyspnea (HP:0002875)2.21556526
68Hyperglycinemia (HP:0002154)2.21208610
69Poikiloderma (HP:0001029)2.20699676
70Increased hepatocellular lipid droplets (HP:0006565)2.20479136
71Stomatitis (HP:0010280)2.19696767
72Sparse lateral eyebrow (HP:0005338)2.17898529
73Reduced antithrombin III activity (HP:0001976)2.17732728
74IgM deficiency (HP:0002850)2.15100204
75Selective tooth agenesis (HP:0001592)2.14722670
76Male infertility (HP:0003251)2.13420649
77Abnormal lung lobation (HP:0002101)2.11398620
78Respiratory failure (HP:0002878)2.11329216
79Pancreatic fibrosis (HP:0100732)2.10606832
80Abnormality of midbrain morphology (HP:0002418)2.10246544
81Molar tooth sign on MRI (HP:0002419)2.10246544
82Severe combined immunodeficiency (HP:0004430)2.09533844
83Aplasia/hypoplasia of the uterus (HP:0008684)2.09450880
84Abnormality of the prostate (HP:0008775)2.09214868
85Facial hemangioma (HP:0000329)2.08499431
86Meckel diverticulum (HP:0002245)2.07919242
87Neutropenia (HP:0001875)2.07858097
88Respiratory difficulties (HP:0002880)2.07630491
89Increased serum lactate (HP:0002151)2.06653954
90True hermaphroditism (HP:0010459)2.05358628
91Neoplasm of the pancreas (HP:0002894)2.05002985
92Overlapping toe (HP:0001845)2.02819194
93Hepatic necrosis (HP:0002605)2.02643923
94Absent radius (HP:0003974)2.02485630
95Lymphoma (HP:0002665)2.01639461
96Triphalangeal thumb (HP:0001199)2.01576953
97Methylmalonic acidemia (HP:0002912)2.00987726
98Lethargy (HP:0001254)2.00524136
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.00514035
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99190197
101Abnormality of the ileum (HP:0001549)1.98570175
102Pancytopenia (HP:0001876)1.97690338
103Abnormality of T cells (HP:0002843)1.97554005
104Absent forearm bone (HP:0003953)1.97108836
105Aplasia involving forearm bones (HP:0009822)1.97108836
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.97058455
107Lipid accumulation in hepatocytes (HP:0006561)1.96890215
108Type I transferrin isoform profile (HP:0003642)1.96775713
109Bone marrow hypocellularity (HP:0005528)1.96179044
110Horseshoe kidney (HP:0000085)1.95380969
111Leukodystrophy (HP:0002415)1.93422897
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.93244046
113Methylmalonic aciduria (HP:0012120)1.92559657
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92385313
115Elevated erythrocyte sedimentation rate (HP:0003565)1.92082836
116Abnormality of serum amino acid levels (HP:0003112)1.92079969
117Adrenal hypoplasia (HP:0000835)1.92072214
118Supernumerary spleens (HP:0009799)1.91533496
119Dicarboxylic aciduria (HP:0003215)1.90433516
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90433516
121Increased intramyocellular lipid droplets (HP:0012240)1.90283406
122Duodenal stenosis (HP:0100867)1.89644277
123Small intestinal stenosis (HP:0012848)1.89644277
124Petechiae (HP:0000967)1.89158448
125Cleft eyelid (HP:0000625)1.88722478
126Squamous cell carcinoma (HP:0002860)1.88659254
127Abnormal trabecular bone morphology (HP:0100671)1.88245426
128Sloping forehead (HP:0000340)1.87953279
129Mitochondrial inheritance (HP:0001427)1.87512295
130Slender long bone (HP:0003100)1.86979158
131Medial flaring of the eyebrow (HP:0010747)1.85184348
132Abnormality of placental membranes (HP:0011409)1.84804203
133Amniotic constriction ring (HP:0009775)1.84804203
134Progressive muscle weakness (HP:0003323)1.84495955
135Abolished electroretinogram (ERG) (HP:0000550)1.83724913
136Atresia of the external auditory canal (HP:0000413)1.82814422
137Abnormal hemoglobin (HP:0011902)1.82763872
138Abnormal biliary tract physiology (HP:0012439)1.82414353
139Bile duct proliferation (HP:0001408)1.82414353
140Pendular nystagmus (HP:0012043)1.81642271
141Agnosia (HP:0010524)1.79361326
142Calcaneovalgus deformity (HP:0001848)1.79100816
143CNS demyelination (HP:0007305)1.79002697
144Stenosis of the external auditory canal (HP:0000402)1.78935139
145Acute necrotizing encephalopathy (HP:0006965)1.77972747
146Increased CSF lactate (HP:0002490)1.77842652
147Granulocytopenia (HP:0001913)1.77640007
148Recurrent fungal infections (HP:0002841)1.75292816
149Thyroiditis (HP:0100646)1.75219310
150IgG deficiency (HP:0004315)1.75111416
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74884611
152Abnormality of T cell physiology (HP:0011840)1.74508017
153Attenuation of retinal blood vessels (HP:0007843)1.72902968
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71041870
155Increased serum pyruvate (HP:0003542)1.69306023
156Nephrogenic diabetes insipidus (HP:0009806)1.68420866
157Chronic mucocutaneous candidiasis (HP:0002728)1.66453533
158Recurrent cutaneous fungal infections (HP:0011370)1.66453533
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.65417458
160Posterior subcapsular cataract (HP:0007787)1.64939527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.95887158
2BUB13.90227610
3MAP4K23.26155406
4CDC73.08710511
5PLK42.92301874
6NME22.85427970
7WEE12.84260036
8TESK22.69614454
9ZAK2.66581407
10EEF2K2.65858103
11ACVR1B2.64835310
12EIF2AK12.53370259
13BCKDK2.19928228
14NUAK12.16503781
15TTK2.11636076
16NEK22.07999637
17MAPKAPK32.07951731
18KSR22.07386657
19MUSK2.04495107
20VRK11.96358425
21BRAF1.93628334
22RPS6KB21.87015346
23SRPK11.86728340
24TLK11.85295189
25RAF11.84170540
26STK161.76501473
27ARAF1.71234976
28TRIM281.69212390
29SCYL21.60750071
30RPS6KA41.60367395
31TAOK11.59552990
32MAP3K61.58422846
33MAP3K121.57790738
34MAP3K81.57372840
35CCNB11.57134554
36PLK11.51524036
37MAP3K131.48950315
38CDK81.42068555
39MOS1.41388619
40DYRK21.40016361
41BMPR21.38553487
42DYRK31.37802876
43BRSK21.36380903
44AURKB1.35702083
45TXK1.34743811
46CHEK21.34610239
47BMPR1B1.33703236
48AURKA1.32786786
49MST41.32164953
50MAP4K11.24139326
51IKBKB1.23317144
52STK101.22968387
53MAPKAPK51.21313262
54MAP3K111.20532121
55MAP3K141.16905303
56CDK71.14068469
57LIMK11.06350484
58BRSK11.05860313
59KDR1.05696387
60TGFBR11.05393003
61BCR1.05174535
62TAOK31.03708713
63MAP3K91.01624731
64EIF2AK31.01277483
65ERBB41.01114006
66NEK10.99322396
67LRRK20.96905656
68ERBB30.96263568
69TBK10.96101530
70WNK30.96015442
71ADRBK20.94677962
72LATS20.92621338
73INSRR0.91165657
74DAPK10.89937853
75ABL20.88455530
76FES0.86225529
77CSF1R0.85755718
78MAP3K40.85147307
79TESK10.84296739
80TYK20.80881351
81GRK10.79494196
82JAK30.78885661
83PIM10.77131513
84ATR0.76962391
85MAP2K70.76303075
86TEC0.75965884
87MKNK10.75810432
88CDK90.75791752
89NME10.75673403
90PIM20.73121742
91CDK40.72218828
92MELK0.71091353
93LYN0.71089854
94STK40.70334286
95TNK20.69196052
96FLT30.67800308
97PAK40.66614230
98SYK0.65905578
99PLK30.64417148
100ILK0.64165204
101CDK190.63244786
102MAPK130.62861593
103CHEK10.59428542
104CSNK1G10.59114245
105GRK70.58798148
106MATK0.57377592
107CSNK1A1L0.57257469
108STK240.56251551
109PDK20.55775099
110CSNK1G20.55432619
111PAK10.54443037
112STK38L0.54210543
113MARK30.52920973
114CDK30.50556643
115TRPM70.50325215
116HIPK20.49647827
117PASK0.49524851
118RPS6KA50.49293291
119PBK0.48433636
120CSNK1G30.46596708
121CDK11A0.45788712
122STK30.45640067
123NLK0.45519529
124ATM0.45446933
125GRK60.45210315
126BTK0.44987615
127PRKCQ0.44399227
128CSNK2A10.44336000
129IKBKE0.42931328
130CDK20.42648953
131KSR10.42517240
132CDK150.41898988
133EIF2AK20.40087227
134MAPK150.39365019
135ZAP700.39001854
136NEK90.38938083
137CLK10.38695262
138CDK180.37401799
139MAPK110.36615464
140CDK140.36465510
141MKNK20.36085085
142KIT0.34595718
143TSSK60.33504477
144CSNK2A20.33330927

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74890659
2Ribosome_Homo sapiens_hsa030104.19516323
3Mismatch repair_Homo sapiens_hsa034303.88234279
4RNA polymerase_Homo sapiens_hsa030203.15916198
5Cell cycle_Homo sapiens_hsa041103.15600418
6Proteasome_Homo sapiens_hsa030503.00728594
7Base excision repair_Homo sapiens_hsa034102.98459232
8Nucleotide excision repair_Homo sapiens_hsa034202.92102818
9Homologous recombination_Homo sapiens_hsa034402.88489494
10Spliceosome_Homo sapiens_hsa030402.73611020
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70859385
12Pyrimidine metabolism_Homo sapiens_hsa002402.53321896
13RNA degradation_Homo sapiens_hsa030182.43615675
14Basal transcription factors_Homo sapiens_hsa030222.40548175
15RNA transport_Homo sapiens_hsa030132.37805302
16Asthma_Homo sapiens_hsa053102.20794023
17One carbon pool by folate_Homo sapiens_hsa006701.93513966
18Allograft rejection_Homo sapiens_hsa053301.79079772
19Non-homologous end-joining_Homo sapiens_hsa034501.76378991
20p53 signaling pathway_Homo sapiens_hsa041151.75210941
21Fanconi anemia pathway_Homo sapiens_hsa034601.72320540
22Autoimmune thyroid disease_Homo sapiens_hsa053201.61812546
23Graft-versus-host disease_Homo sapiens_hsa053321.60221782
24Protein export_Homo sapiens_hsa030601.52297502
25Type I diabetes mellitus_Homo sapiens_hsa049401.41038139
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28813146
27Systemic lupus erythematosus_Homo sapiens_hsa053221.22608968
28Fatty acid elongation_Homo sapiens_hsa000621.21981569
29Purine metabolism_Homo sapiens_hsa002301.19874612
30Folate biosynthesis_Homo sapiens_hsa007901.16934326
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16204895
32Primary immunodeficiency_Homo sapiens_hsa053401.13099643
33Huntingtons disease_Homo sapiens_hsa050161.11776031
34Oocyte meiosis_Homo sapiens_hsa041141.09940377
35Epstein-Barr virus infection_Homo sapiens_hsa051691.08447161
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07120652
37Parkinsons disease_Homo sapiens_hsa050121.06138167
38Sulfur relay system_Homo sapiens_hsa041221.05287831
39mRNA surveillance pathway_Homo sapiens_hsa030151.05036111
40Rheumatoid arthritis_Homo sapiens_hsa053231.04699676
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04330013
42Herpes simplex infection_Homo sapiens_hsa051681.04269322
43Thyroid cancer_Homo sapiens_hsa052161.03687705
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02385315
45Antigen processing and presentation_Homo sapiens_hsa046120.98850107
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98151912
47Viral carcinogenesis_Homo sapiens_hsa052030.90789915
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88112171
49Oxidative phosphorylation_Homo sapiens_hsa001900.86166075
50Collecting duct acid secretion_Homo sapiens_hsa049660.83614306
51Sulfur metabolism_Homo sapiens_hsa009200.83388609
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83065342
53Shigellosis_Homo sapiens_hsa051310.79389546
54Propanoate metabolism_Homo sapiens_hsa006400.78032705
55Colorectal cancer_Homo sapiens_hsa052100.77721952
56Pancreatic cancer_Homo sapiens_hsa052120.75995522
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75743459
58HTLV-I infection_Homo sapiens_hsa051660.75308488
59Phototransduction_Homo sapiens_hsa047440.72533751
60Vitamin B6 metabolism_Homo sapiens_hsa007500.72026909
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72005419
62Regulation of autophagy_Homo sapiens_hsa041400.71650990
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.71134656
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67566974
65TGF-beta signaling pathway_Homo sapiens_hsa043500.67294465
66Peroxisome_Homo sapiens_hsa041460.66778689
67Leishmaniasis_Homo sapiens_hsa051400.66763838
68Pentose phosphate pathway_Homo sapiens_hsa000300.66198804
69Cardiac muscle contraction_Homo sapiens_hsa042600.65198184
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64423930
71Hepatitis B_Homo sapiens_hsa051610.62205768
72Bladder cancer_Homo sapiens_hsa052190.62198660
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60038387
74Apoptosis_Homo sapiens_hsa042100.59452983
75Small cell lung cancer_Homo sapiens_hsa052220.56949301
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56495779
77Alcoholism_Homo sapiens_hsa050340.55826375
78Glutathione metabolism_Homo sapiens_hsa004800.54409406
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53968859
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52850899
81Staphylococcus aureus infection_Homo sapiens_hsa051500.51306010
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50000811
83Measles_Homo sapiens_hsa051620.49653975
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49459713
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.48680348
86Linoleic acid metabolism_Homo sapiens_hsa005910.48235188
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47697226
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47487725
89Hematopoietic cell lineage_Homo sapiens_hsa046400.45524979
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44938589
91MicroRNAs in cancer_Homo sapiens_hsa052060.43872469
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43861088
93Alzheimers disease_Homo sapiens_hsa050100.43170145
94Chronic myeloid leukemia_Homo sapiens_hsa052200.42894804
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.42413451
96Ether lipid metabolism_Homo sapiens_hsa005650.40500697
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.39222995
98Acute myeloid leukemia_Homo sapiens_hsa052210.39053432
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.38668813
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38333800
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38268405
102Circadian rhythm_Homo sapiens_hsa047100.37610732
103T cell receptor signaling pathway_Homo sapiens_hsa046600.36028101
104Notch signaling pathway_Homo sapiens_hsa043300.35932646
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35320984
106Butanoate metabolism_Homo sapiens_hsa006500.35257399
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34175752
108Pyruvate metabolism_Homo sapiens_hsa006200.33862432
109Other glycan degradation_Homo sapiens_hsa005110.32940934
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32789079
111Biosynthesis of amino acids_Homo sapiens_hsa012300.31961940
112Carbon metabolism_Homo sapiens_hsa012000.31454839
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31271478
114VEGF signaling pathway_Homo sapiens_hsa043700.30628115
115Chemical carcinogenesis_Homo sapiens_hsa052040.30533719
116Legionellosis_Homo sapiens_hsa051340.29796123
117Olfactory transduction_Homo sapiens_hsa047400.29332345
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28335123
119Viral myocarditis_Homo sapiens_hsa054160.27941189
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26376346
121B cell receptor signaling pathway_Homo sapiens_hsa046620.26056953
122Selenocompound metabolism_Homo sapiens_hsa004500.24963930
123Tuberculosis_Homo sapiens_hsa051520.24768365
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.23991307
125N-Glycan biosynthesis_Homo sapiens_hsa005100.23222257
126Hippo signaling pathway_Homo sapiens_hsa043900.23205955
127Phagosome_Homo sapiens_hsa041450.23039242
128Prolactin signaling pathway_Homo sapiens_hsa049170.21971191
129Non-small cell lung cancer_Homo sapiens_hsa052230.21309076
130Arachidonic acid metabolism_Homo sapiens_hsa005900.20998677
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20474302
132Renal cell carcinoma_Homo sapiens_hsa052110.20164588
133Metabolic pathways_Homo sapiens_hsa011000.20107661
134Influenza A_Homo sapiens_hsa051640.18143665
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17757257
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15237362

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