MED25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00359338
2negative regulation of cell killing (GO:0031342)5.00359338
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97606733
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.97606733
5modulation by symbiont of host immune response (GO:0052553)4.97606733
6positive regulation by symbiont of host defense response (GO:0052509)4.97606733
7modulation by symbiont of host defense response (GO:0052031)4.97606733
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97606733
9negative regulation of erythrocyte differentiation (GO:0045647)4.92311178
10DNA deamination (GO:0045006)4.73435789
11histone H4-K12 acetylation (GO:0043983)4.71085726
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63852400
13paraxial mesoderm development (GO:0048339)4.58685250
14regulation of nuclear cell cycle DNA replication (GO:0033262)4.51307832
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48746525
16positive regulation of gamma-delta T cell activation (GO:0046645)4.28893111
17antigen processing and presentation of endogenous antigen (GO:0019883)4.23285565
18response to peptidoglycan (GO:0032494)4.19700563
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10087499
20macrophage activation involved in immune response (GO:0002281)4.06496827
21detection of other organism (GO:0098543)3.98489473
22detection of bacterium (GO:0016045)3.95932701
23neutrophil activation involved in immune response (GO:0002283)3.80396149
24regulation of interferon-beta biosynthetic process (GO:0045357)3.75546247
25mitochondrial DNA metabolic process (GO:0032042)3.75003615
26DNA replication checkpoint (GO:0000076)3.63938326
27regulation of gene silencing by RNA (GO:0060966)3.60862344
28regulation of posttranscriptional gene silencing (GO:0060147)3.60862344
29regulation of gene silencing by miRNA (GO:0060964)3.60862344
30regulation of gamma-delta T cell activation (GO:0046643)3.57186042
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56534154
32germinal center formation (GO:0002467)3.53828775
33DNA strand elongation involved in DNA replication (GO:0006271)3.48381178
34detection of external biotic stimulus (GO:0098581)3.43153731
35mitochondrial DNA replication (GO:0006264)3.39436383
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38041129
37histone H4-K8 acetylation (GO:0043982)3.37855731
38histone H4-K5 acetylation (GO:0043981)3.37855731
39positive regulation of Cdc42 GTPase activity (GO:0043089)3.36428431
40histone arginine methylation (GO:0034969)3.34234970
41negative regulation of interleukin-12 production (GO:0032695)3.33624995
42telomere maintenance via semi-conservative replication (GO:0032201)3.31653261
43regulation of telomere maintenance via telomerase (GO:0032210)3.31415428
44leukocyte aggregation (GO:0070486)3.29326309
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.29279845
46DNA strand elongation (GO:0022616)3.29002857
47regulation of T-helper 2 cell differentiation (GO:0045628)3.28878602
48peptidyl-arginine omega-N-methylation (GO:0035247)3.27822319
49response to muramyl dipeptide (GO:0032495)3.27663041
50immunoglobulin mediated immune response (GO:0016064)3.26310494
513-UTR-mediated mRNA stabilization (GO:0070935)3.26185207
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25722349
53regulation of mast cell degranulation (GO:0043304)3.24330824
54establishment of apical/basal cell polarity (GO:0035089)3.21087280
55detection of molecule of bacterial origin (GO:0032490)3.20951937
56regulation of gamma-delta T cell differentiation (GO:0045586)3.20122678
57positive thymic T cell selection (GO:0045059)3.19105309
58response to host immune response (GO:0052572)3.18260870
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18260870
60positive regulation of histone deacetylation (GO:0031065)3.17418978
61ribosome assembly (GO:0042255)3.16951215
62regulation of leukocyte degranulation (GO:0043300)3.16793054
63synaptonemal complex assembly (GO:0007130)3.15400583
64modulation by virus of host process (GO:0019054)3.14305071
65response to type I interferon (GO:0034340)3.13899430
66regulation of hippo signaling (GO:0035330)3.12803241
67type I interferon signaling pathway (GO:0060337)3.11184959
68cellular response to type I interferon (GO:0071357)3.11184959
69ribosome biogenesis (GO:0042254)3.10707807
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10475356
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.10047713
72DNA replication initiation (GO:0006270)3.09781251
73negative regulation of leukocyte mediated immunity (GO:0002704)3.09140122
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08408586
75response to host (GO:0075136)3.07638830
76response to host defenses (GO:0052200)3.07638830
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07638830
78modulation by symbiont of host cellular process (GO:0044068)3.07574824
79mannose metabolic process (GO:0006013)3.06357834
80negative regulation of mRNA processing (GO:0050686)3.05792859
81respiratory burst (GO:0045730)3.05390844
82regulation of B cell receptor signaling pathway (GO:0050855)3.04487254
83pre-miRNA processing (GO:0031054)3.04133413
84DNA damage response, signal transduction resulting in transcription (GO:0042772)3.03007210
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.01116865
86heterochromatin organization (GO:0070828)2.99919927
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99363496
88detection of biotic stimulus (GO:0009595)2.99040440
89cellular response to virus (GO:0098586)2.97935242
90proline biosynthetic process (GO:0006561)2.97861989
91tolerance induction (GO:0002507)2.97045793
92histone H2A acetylation (GO:0043968)2.95173605
93mitotic metaphase plate congression (GO:0007080)2.94433671
94neutrophil activation (GO:0042119)2.94191450
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.93836930
96negative regulation of RNA splicing (GO:0033119)2.92769442
97negative regulation of phagocytosis (GO:0050765)2.91652241
98cellular extravasation (GO:0045123)2.91628014
99NIK/NF-kappaB signaling (GO:0038061)2.90577519
100negative regulation of chromosome segregation (GO:0051985)2.90129211
101DNA damage induced protein phosphorylation (GO:0006975)2.88295392
102regulation of ARF GTPase activity (GO:0032312)2.87483789
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86615470
104thymic T cell selection (GO:0045061)2.86507040
105granulocyte activation (GO:0036230)2.85788287
106B cell receptor signaling pathway (GO:0050853)2.82893449
107protein complex localization (GO:0031503)2.82877549
108DNA strand renaturation (GO:0000733)2.82053462
109folic acid-containing compound biosynthetic process (GO:0009396)2.82004120
110regulation of mast cell activation involved in immune response (GO:0033006)2.81893986
111negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81343223
112negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81343223
113telomere maintenance via telomere lengthening (GO:0010833)2.80754519
114DNA unwinding involved in DNA replication (GO:0006268)2.80422330
115oxygen transport (GO:0015671)2.79373606
116intracellular estrogen receptor signaling pathway (GO:0030520)2.78869291
117formation of translation preinitiation complex (GO:0001731)2.78629193
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75708739
119negative regulation of sister chromatid segregation (GO:0033046)2.75708739
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.75708739
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75708739
122mitotic spindle assembly checkpoint (GO:0007094)2.75154875
123establishment of monopolar cell polarity (GO:0061162)2.73789694
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.73789694
125telomere maintenance via recombination (GO:0000722)2.73026632
126signal complex assembly (GO:0007172)2.72174595
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71525008
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71273246
129peptidyl-arginine methylation (GO:0018216)2.71169563
130peptidyl-arginine N-methylation (GO:0035246)2.71169563
131synaptonemal complex organization (GO:0070193)2.70266296
132regulation of necroptotic process (GO:0060544)2.70041329
133spliceosomal snRNP assembly (GO:0000387)2.69594662
134response to interleukin-15 (GO:0070672)2.69381280
135spindle assembly checkpoint (GO:0071173)2.68693644
136negative regulation of mRNA metabolic process (GO:1903312)2.68345367
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68286822
138myeloid cell activation involved in immune response (GO:0002275)2.68253699
139positive regulation of protein deacetylation (GO:0090312)2.66336341
140tRNA methylation (GO:0030488)2.64420533
141nucleobase biosynthetic process (GO:0046112)2.63168368
142regulation of regulated secretory pathway (GO:1903305)2.63164574
143regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63124509
144mitotic nuclear envelope disassembly (GO:0007077)2.62161122
145negative regulation of innate immune response (GO:0045824)2.62109776
146negative regulation of type 2 immune response (GO:0002829)2.61541843
147macrophage activation (GO:0042116)2.61455777
148piRNA metabolic process (GO:0034587)2.60896040
149response to laminar fluid shear stress (GO:0034616)2.60859313
150antigen processing and presentation via MHC class Ib (GO:0002475)2.60464683
151kinetochore assembly (GO:0051382)2.60305436
152negative regulation of interleukin-6 production (GO:0032715)2.59324216
153lung-associated mesenchyme development (GO:0060484)2.58853599
154inner cell mass cell proliferation (GO:0001833)2.58655367
155spliceosomal complex assembly (GO:0000245)2.57877146
156DNA-dependent DNA replication (GO:0006261)2.56505177
157RNA splicing, via transesterification reactions (GO:0000375)2.55945952
158negative regulation of telomerase activity (GO:0051974)2.55766970
159signal transduction involved in regulation of gene expression (GO:0023019)2.55259404
160folic acid metabolic process (GO:0046655)2.55175970
161maturation of 5.8S rRNA (GO:0000460)2.55123147
162proline metabolic process (GO:0006560)2.54939314
163negative regulation of cytokine production involved in immune response (GO:0002719)2.54365634
164RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.53914577
165mRNA splicing, via spliceosome (GO:0000398)2.53914577
166T cell selection (GO:0045058)2.53731853
167regulation of tolerance induction (GO:0002643)2.53334754
168apoptotic process involved in morphogenesis (GO:0060561)2.53260560
169DNA synthesis involved in DNA repair (GO:0000731)2.51972463
170negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51482293
171negative regulation of viral release from host cell (GO:1902187)2.50957353
172mitotic spindle checkpoint (GO:0071174)2.50792172
173proteasome assembly (GO:0043248)2.50548703
174DNA replication-dependent nucleosome assembly (GO:0006335)2.50280574
175DNA replication-dependent nucleosome organization (GO:0034723)2.50280574
176IMP biosynthetic process (GO:0006188)2.49826419
177negative regulation of T cell mediated immunity (GO:0002710)2.49220578
178regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49201337
179deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48778700
180transcription-coupled nucleotide-excision repair (GO:0006283)2.48756817
181termination of RNA polymerase II transcription (GO:0006369)2.48420285
182receptor recycling (GO:0001881)2.47910593
183epithelial cell fate commitment (GO:0072148)2.47618327
184mitotic recombination (GO:0006312)2.47516209
185gas transport (GO:0015669)2.47400848
186meiotic chromosome segregation (GO:0045132)2.47222401
187replicative senescence (GO:0090399)2.47149402
188protein localization to endosome (GO:0036010)2.47090377
189base-excision repair (GO:0006284)2.46915827
190DNA duplex unwinding (GO:0032508)2.46183243
191regulation of type 2 immune response (GO:0002828)2.46056513
192protein localization to kinetochore (GO:0034501)2.45588209
193defense response to protozoan (GO:0042832)2.44169354
194DNA geometric change (GO:0032392)2.44040333
195positive regulation of type 2 immune response (GO:0002830)2.43947801
196negative regulation of myotube differentiation (GO:0010832)2.43789481
197negative regulation of cAMP-mediated signaling (GO:0043951)2.42498792
198regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40266308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.29595924
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.57709052
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.43231656
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84067284
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.76804151
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75638570
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69850269
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66311548
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.48811813
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.47850605
11TCF7_22412390_ChIP-Seq_EML_Mouse2.45312474
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.44262664
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44229454
14KDM2B_26808549_Chip-Seq_DND41_Human2.40446842
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35063526
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33847118
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29883574
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27030916
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25896767
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.25531063
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20761117
22VDR_24763502_ChIP-Seq_THP-1_Human2.20443035
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.12451075
24XRN2_22483619_ChIP-Seq_HELA_Human2.11183928
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07418308
26MAF_26560356_Chip-Seq_TH1_Human2.06226815
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04278688
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01849315
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01849315
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01849315
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98825839
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96772779
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94104737
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93800991
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92586247
36UTX_26944678_Chip-Seq_JUKART_Human1.87496520
37MYC_22102868_ChIP-Seq_BL_Human1.86092621
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85784335
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85653578
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.85580771
41KDM2B_26808549_Chip-Seq_K562_Human1.82007890
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.81043114
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.80398437
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79639282
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79397308
46* CIITA_25753668_ChIP-Seq_RAJI_Human1.78869813
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78233317
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75652969
49MAF_26560356_Chip-Seq_TH2_Human1.73969368
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70613434
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70595907
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67347539
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.66796697
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66170814
55SPI1_23127762_ChIP-Seq_K562_Human1.65911465
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65347108
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.64958292
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64549519
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.63452096
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62529589
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.62322561
62GABP_19822575_ChIP-Seq_HepG2_Human1.59465360
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.58998289
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58081097
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58069836
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.57292191
67SMC4_20622854_ChIP-Seq_HELA_Human1.56629807
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.55481118
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54805388
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54141735
71BCOR_27268052_Chip-Seq_Bcells_Human1.53580415
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51946570
73TTF2_22483619_ChIP-Seq_HELA_Human1.51873027
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50874110
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50533480
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49316474
77* BCL6_27268052_Chip-Seq_Bcells_Human1.49132134
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48811073
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48007427
80NCOR1_26117541_ChIP-Seq_K562_Human1.47265081
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45999840
82SCL_19346495_ChIP-Seq_HPC-7_Human1.45299417
83GATA1_19941826_ChIP-Seq_K562_Human1.45177542
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43477404
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43011391
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42500374
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41486906
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40874334
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39878847
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.39228202
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.39116645
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38969195
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38579180
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37612259
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37159402
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36163151
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36059266
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35245187
99CREB1_26743006_Chip-Seq_LNCaP_Human1.34789228
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34378930
101P68_20966046_ChIP-Seq_HELA_Human1.33338781
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33218433
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.32635235
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31862581
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.31578586
106KDM5A_27292631_Chip-Seq_BREAST_Human1.30897145
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30573609
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29205584
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29114648
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28939401
111DCP1A_22483619_ChIP-Seq_HELA_Human1.28848144
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.28025955
113* NANOG_21062744_ChIP-ChIP_HESCs_Human1.27980962
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27932142
115* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27146842
116SPI1_23547873_ChIP-Seq_NB4_Human1.26793103
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26299079
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25705290
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25522927
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24632198
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24188607
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23381220
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23142708
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22760257
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22543940
126FOXP3_21729870_ChIP-Seq_TREG_Human1.21956189
127POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21718403
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20924864
129* VDR_23849224_ChIP-Seq_CD4+_Human1.20617938
130KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20452423
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19651876
132* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19612042
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19114335
134LXR_22292898_ChIP-Seq_THP-1_Human1.18507076
135DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18064143
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15735017
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15569338
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15479870
139PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15086376
140NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14909420
141PHF8_20622854_ChIP-Seq_HELA_Human1.14891351
142* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14837272
143VDR_21846776_ChIP-Seq_THP-1_Human1.13851124
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13215170
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12854600
146ESR2_21235772_ChIP-Seq_MCF-7_Human1.12693758
147* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11880858
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11869025
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11633102
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11621200
151CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09977097
152MYB_26560356_Chip-Seq_TH1_Human1.09900237
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09347263
154TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09164628
155ERG_21242973_ChIP-ChIP_JURKAT_Human1.08974828
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08493808
157RUNX1_27514584_Chip-Seq_MCF-7_Human1.06468809
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06468438
159* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06266679
160RACK7_27058665_Chip-Seq_MCF-7_Human1.05902970
161P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05573064
162* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05206811
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05091015
164CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04833787
165BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04249695
166SA1_27219007_Chip-Seq_Bcells_Human1.03901795
167E2F1_20622854_ChIP-Seq_HELA_Human1.03749569
168TP63_22573176_ChIP-Seq_HFKS_Human1.03243686
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03018155
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01993292
171TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00968865
172CTCF_26484167_Chip-Seq_Bcells_Mouse1.00460720
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00163131
174OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00106164
175RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00040876
176* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99591487
177CTCF_21964334_Chip-Seq_Bcells_Human0.99557975
178TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99557942
179TP63_17297297_ChIP-ChIP_HaCaT_Human0.99404762
180CTCF_27219007_Chip-Seq_Bcells_Human0.99370104
181AR_21909140_ChIP-Seq_LNCAP_Human0.98625861
182* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98451928
183ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98424754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.17001540
2MP0003436_decreased_susceptibility_to3.96137570
3MP0003111_abnormal_nucleus_morphology3.66765847
4MP0003693_abnormal_embryo_hatching3.57035596
5MP0003283_abnormal_digestive_organ3.39877759
6MP0010030_abnormal_orbit_morphology3.27918239
7MP0002653_abnormal_ependyma_morphology3.19580805
8MP0005451_abnormal_body_composition2.97458611
9MP0003724_increased_susceptibility_to2.91933614
10MP0003705_abnormal_hypodermis_morpholog2.51359425
11MP0003172_abnormal_lysosome_physiology2.50412621
12MP0004957_abnormal_blastocyst_morpholog2.48786909
13MP0003077_abnormal_cell_cycle2.46281312
14MP0002419_abnormal_innate_immunity2.45359490
15MP0001835_abnormal_antigen_presentation2.45247686
16MP0000685_abnormal_immune_system2.44841074
17MP0010094_abnormal_chromosome_stability2.40697777
18MP0005025_abnormal_response_to2.39357152
19MP0008260_abnormal_autophagy2.37938897
20MP0008058_abnormal_DNA_repair2.37456184
21MP0003119_abnormal_digestive_system2.34718574
22MP0001790_abnormal_immune_system2.34459174
23MP0005387_immune_system_phenotype2.34459174
24MP0003300_gastrointestinal_ulcer2.32780133
25MP0008877_abnormal_DNA_methylation2.31313001
26MP0006292_abnormal_olfactory_placode2.29389155
27MP0005058_abnormal_lysosome_morphology2.28920206
28MP0003191_abnormal_cellular_cholesterol2.20541255
29MP0003878_abnormal_ear_physiology2.18003570
30MP0005377_hearing/vestibular/ear_phenot2.18003570
31MP0008057_abnormal_DNA_replication2.17931449
32MP0000678_abnormal_parathyroid_gland2.13014244
33MP0005000_abnormal_immune_tolerance2.12856233
34MP0003786_premature_aging2.12601639
35MP0000566_synostosis2.10513881
36MP0001800_abnormal_humoral_immune2.05489071
37MP0002234_abnormal_pharynx_morphology1.97390848
38MP0008995_early_reproductive_senescence1.93065162
39MP0002420_abnormal_adaptive_immunity1.92445164
40MP0002723_abnormal_immune_serum1.92403433
41MP0001819_abnormal_immune_cell1.91444216
42MP0002132_abnormal_respiratory_system1.90108461
43MP0004947_skin_inflammation1.88609714
44MP0006082_CNS_inflammation1.87822750
45MP0002452_abnormal_antigen_presenting1.86570155
46MP0009785_altered_susceptibility_to1.85937550
47MP0004133_heterotaxia1.84723192
48MP0001533_abnormal_skeleton_physiology1.83367306
49MP0008932_abnormal_embryonic_tissue1.81956960
50MP0005671_abnormal_response_to1.79990093
51MP0009333_abnormal_splenocyte_physiolog1.78883957
52MP0003763_abnormal_thymus_physiology1.78850628
53MP0004510_myositis1.72198772
54MP0003890_abnormal_embryonic-extraembry1.72058245
55MP0003123_paternal_imprinting1.71539153
56MP0002085_abnormal_embryonic_tissue1.70527794
57MP0005670_abnormal_white_adipose1.69368322
58MP0002405_respiratory_system_inflammati1.69353666
59MP0001545_abnormal_hematopoietic_system1.68351389
60MP0005397_hematopoietic_system_phenotyp1.68351389
61MP0004858_abnormal_nervous_system1.65808135
62MP0005083_abnormal_biliary_tract1.65086063
63MP0002398_abnormal_bone_marrow1.63652260
64MP0008007_abnormal_cellular_replicative1.62232357
65MP0010155_abnormal_intestine_physiology1.60705102
66MP0003656_abnormal_erythrocyte_physiolo1.57154604
67MP0003183_abnormal_peptide_metabolism1.56811571
68MP0002148_abnormal_hypersensitivity_rea1.55996444
69MP0003941_abnormal_skin_development1.54746867
70MP0001730_embryonic_growth_arrest1.54722638
71MP0009840_abnormal_foam_cell1.54062502
72MP0005380_embryogenesis_phenotype1.53774601
73MP0001672_abnormal_embryogenesis/_devel1.53774601
74MP0001293_anophthalmia1.53070199
75MP0002084_abnormal_developmental_patter1.51646531
76MP0000716_abnormal_immune_system1.49948105
77MP0003453_abnormal_keratinocyte_physiol1.49066437
78MP0000858_altered_metastatic_potential1.48915733
79MP0004233_abnormal_muscle_weight1.44996140
80MP0005464_abnormal_platelet_physiology1.44136871
81MP0004197_abnormal_fetal_growth/weight/1.41451961
82MP0000350_abnormal_cell_proliferation1.41017144
83MP0002249_abnormal_larynx_morphology1.40727778
84MP0000537_abnormal_urethra_morphology1.39897731
85MP0005310_abnormal_salivary_gland1.38619941
86MP0001697_abnormal_embryo_size1.38325685
87MP0002396_abnormal_hematopoietic_system1.37803822
88MP0002722_abnormal_immune_system1.35508179
89MP0000428_abnormal_craniofacial_morphol1.35433598
90MP0000703_abnormal_thymus_morphology1.34625961
91MP0003984_embryonic_growth_retardation1.31469357
92MP0000049_abnormal_middle_ear1.30625244
93MP0002429_abnormal_blood_cell1.30147822
94MP0002210_abnormal_sex_determination1.28946613
95MP0002088_abnormal_embryonic_growth/wei1.28870302
96MP0001845_abnormal_inflammatory_respons1.25564768
97MP0004381_abnormal_hair_follicle1.24977979
98MP0002938_white_spotting1.24834084
99MP0000462_abnormal_digestive_system1.24660150
100MP0005076_abnormal_cell_differentiation1.23214751
101MP0002102_abnormal_ear_morphology1.21792484
102MP0002998_abnormal_bone_remodeling1.21424698
103MP0003646_muscle_fatigue1.21178305
104MP0002080_prenatal_lethality1.20779867
105MP0003828_pulmonary_edema1.20664993
106MP0000689_abnormal_spleen_morphology1.20599543
107MP0003121_genomic_imprinting1.19806352
108MP0001145_abnormal_male_reproductive1.18536608
109MP0003315_abnormal_perineum_morphology1.17021589
110MP0003866_abnormal_defecation1.14289046
111MP0008789_abnormal_olfactory_epithelium1.14126264
112MP0003567_abnormal_fetal_cardiomyocyte1.14062189
113MP0002111_abnormal_tail_morphology1.13499312
114MP0003075_altered_response_to1.13378948
115MP0008469_abnormal_protein_level1.11822805
116MP0002269_muscular_atrophy1.11791952
117MP0003718_maternal_effect1.11770970
118MP0003045_fibrosis1.11102085
119MP0000613_abnormal_salivary_gland1.10605809
120MP0004808_abnormal_hematopoietic_stem1.09853402
121MP0003091_abnormal_cell_migration1.07379056
122MP0002086_abnormal_extraembryonic_tissu1.07219007
123MP0009053_abnormal_anal_canal1.07058072
124MP0003122_maternal_imprinting1.06631958
125MP0003935_abnormal_craniofacial_develop1.06534043
126MP0003566_abnormal_cell_adhesion1.05770599
127MP0002160_abnormal_reproductive_system1.05188420
128MP0010352_gastrointestinal_tract_polyps1.05118759
129MP0009672_abnormal_birth_weight1.04055365
130MP0000750_abnormal_muscle_regeneration1.03159433
131MP0002116_abnormal_craniofacial_bone1.00960585
132MP0005257_abnormal_intraocular_pressure1.00637573
133MP0001929_abnormal_gametogenesis1.00100733
134MP0001873_stomach_inflammation0.99718170
135MP0000313_abnormal_cell_death0.99491943
136MP0002751_abnormal_autonomic_nervous0.98086383
137MP0001348_abnormal_lacrimal_gland0.97789651
138MP0008004_abnormal_stomach_pH0.97465720
139MP0000653_abnormal_sex_gland0.97008059
140MP0006072_abnormal_retinal_apoptosis0.96822689
141MP0005390_skeleton_phenotype0.96576476
142MP0003115_abnormal_respiratory_system0.96177938
143MP0003942_abnormal_urinary_system0.95081792
144MP0001286_abnormal_eye_development0.94901512
145MP0002697_abnormal_eye_size0.94730550
146MP0004264_abnormal_extraembryonic_tissu0.94174945
147MP0004185_abnormal_adipocyte_glucose0.94001098
148MP0009278_abnormal_bone_marrow0.93727045
149MP0005499_abnormal_olfactory_system0.93452849
150MP0005394_taste/olfaction_phenotype0.93452849
151MP0002092_abnormal_eye_morphology0.92411979
152MP0003861_abnormal_nervous_system0.91234703
153MP0003937_abnormal_limbs/digits/tail_de0.90526336
154MP0000490_abnormal_crypts_of0.89720161
155MP0002932_abnormal_joint_morphology0.88015318
156MP0005666_abnormal_adipose_tissue0.87686857
157MP0000762_abnormal_tongue_morphology0.86148936
158MP0000432_abnormal_head_morphology0.83798041
159MP0009764_decreased_sensitivity_to0.83321801
160MP0003755_abnormal_palate_morphology0.82510655
161MP0008961_abnormal_basal_metabolism0.80725280
162MP0003137_abnormal_impulse_conducting0.80053439
163MP0003329_amyloid_beta_deposits0.80005410
164MP0001849_ear_inflammation0.78488614
165MP0002127_abnormal_cardiovascular_syste0.76481738
166MP0009703_decreased_birth_body0.76379104
167MP0001663_abnormal_digestive_system0.76376867
168MP0008874_decreased_physiological_sensi0.76368406
169MP0005166_decreased_susceptibility_to0.75958647
170MP0010307_abnormal_tumor_latency0.75957463
171MP0000003_abnormal_adipose_tissue0.75542608
172MP0000467_abnormal_esophagus_morphology0.75459937
173MP0002277_abnormal_respiratory_mucosa0.75117734
174MP0001851_eye_inflammation0.74895250
175MP0003279_aneurysm0.74833005
176MP0002114_abnormal_axial_skeleton0.74464143
177MP0005375_adipose_tissue_phenotype0.74077942
178MP0005389_reproductive_system_phenotype0.73615705
179MP0003690_abnormal_glial_cell0.70417041
180MP0002254_reproductive_system_inflammat0.67531903
181MP0009931_abnormal_skin_appearance0.66581912
182MP0005409_darkened_coat_color0.66486586
183MP0003448_altered_tumor_morphology0.66127723
184MP0002933_joint_inflammation0.65302348
185MP0004130_abnormal_muscle_cell0.64880902
186MP0000681_abnormal_thyroid_gland0.64809640
187MP0000343_altered_response_to0.63526599
188MP0005621_abnormal_cell_physiology0.62597593
189MP0003879_abnormal_hair_cell0.62004166
190MP0003795_abnormal_bone_structure0.61929776

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.98933186
2Recurrent abscess formation (HP:0002722)4.34159004
3Recurrent bacterial skin infections (HP:0005406)4.26954350
4Abnormality of macrophages (HP:0004311)4.07773838
5Myositis (HP:0100614)3.92511922
6Nasal polyposis (HP:0100582)3.60616389
7Orchitis (HP:0100796)3.55821388
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48434588
9Hypochromic microcytic anemia (HP:0004840)3.42439191
10Chronic obstructive pulmonary disease (HP:0006510)3.39809862
11Obstructive lung disease (HP:0006536)3.39809862
12Recurrent gram-negative bacterial infections (HP:0005420)3.36020758
13Abnormality of the nasal mucosa (HP:0000433)3.30220431
14Increased IgE level (HP:0003212)3.25695215
15Gastrointestinal infarctions (HP:0005244)3.24384180
16Obstructive sleep apnea (HP:0002870)3.22216640
17Hypochromic anemia (HP:0001931)3.18312299
18Cellulitis (HP:0100658)3.15425841
19Breast hypoplasia (HP:0003187)3.11895151
20Patellar aplasia (HP:0006443)3.06873532
21Optic neuritis (HP:0100653)2.98797013
22Retrobulbar optic neuritis (HP:0100654)2.98797013
23Chromsome breakage (HP:0040012)2.98238402
24Gingivitis (HP:0000230)2.97337234
25Aplasia/Hypoplasia of the patella (HP:0006498)2.96803856
26Absent radius (HP:0003974)2.95935914
27Mediastinal lymphadenopathy (HP:0100721)2.95867057
28Elevated erythrocyte sedimentation rate (HP:0003565)2.94105271
29Abnormal number of incisors (HP:0011064)2.84718139
30Aplasia involving forearm bones (HP:0009822)2.83938016
31Absent forearm bone (HP:0003953)2.83938016
32Meningitis (HP:0001287)2.80106106
33Progressive muscle weakness (HP:0003323)2.78412618
34Unilateral renal agenesis (HP:0000122)2.78253830
35Spontaneous hematomas (HP:0007420)2.73055903
36Birth length less than 3rd percentile (HP:0003561)2.69219323
37Glioma (HP:0009733)2.68457744
38Recurrent fungal infections (HP:0002841)2.67214664
39Recurrent skin infections (HP:0001581)2.67129408
40Gastrointestinal inflammation (HP:0004386)2.65063247
41Ependymoma (HP:0002888)2.61786210
42Renal duplication (HP:0000075)2.60466629
43Rib fusion (HP:0000902)2.59436155
44Selective tooth agenesis (HP:0001592)2.59269000
45Abnormality of the fingertips (HP:0001211)2.59055819
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58496691
47Maternal diabetes (HP:0009800)2.58311625
48Metaphyseal cupping (HP:0003021)2.57127310
49Stomatitis (HP:0010280)2.56290625
50Urticaria (HP:0001025)2.47729032
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.46679794
52Absent thumb (HP:0009777)2.45943473
53Inflammation of the large intestine (HP:0002037)2.45654919
54Progressive external ophthalmoplegia (HP:0000590)2.44768471
55Abnormality of the ileum (HP:0001549)2.44178119
56Osteomalacia (HP:0002749)2.42672126
57Meckel diverticulum (HP:0002245)2.41804184
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.40293559
59Increased cerebral lipofuscin (HP:0011813)2.40038591
60Duplicated collecting system (HP:0000081)2.36389171
61Trismus (HP:0000211)2.34062240
62Colitis (HP:0002583)2.33990880
63Increased connective tissue (HP:0009025)2.33933168
64Anal stenosis (HP:0002025)2.31503480
65Prolonged bleeding time (HP:0003010)2.29770131
66Vasculitis (HP:0002633)2.27500666
67Broad face (HP:0000283)2.26799154
68Microcytic anemia (HP:0001935)2.26643440
69Large for gestational age (HP:0001520)2.26513762
70Easy fatigability (HP:0003388)2.25970477
71Loss of speech (HP:0002371)2.23957687
72Hyperacusis (HP:0010780)2.22944827
73Abnormality of the aortic arch (HP:0012303)2.22127233
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.22054789
75Polycythemia (HP:0001901)2.21944073
76Chest pain (HP:0100749)2.20756445
77Shawl scrotum (HP:0000049)2.20385687
78Hemorrhage of the eye (HP:0011885)2.18704439
79Increased serum ferritin (HP:0003281)2.18427269
80Neoplasm of the oral cavity (HP:0100649)2.16587079
81Impulsivity (HP:0100710)2.15327500
82Keratoconjunctivitis sicca (HP:0001097)2.14100979
83Pustule (HP:0200039)2.13513658
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13410687
85Carpal bone hypoplasia (HP:0001498)2.12484539
86Hypertensive crisis (HP:0100735)2.12083856
87Testicular atrophy (HP:0000029)2.11407697
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.10592710
89Encephalitis (HP:0002383)2.10008944
90Prominent metopic ridge (HP:0005487)2.09455310
91Reticulocytosis (HP:0001923)2.08131331
92Abnormality of the preputium (HP:0100587)2.07985064
93Slow saccadic eye movements (HP:0000514)2.07429702
94Segmental peripheral demyelination/remyelination (HP:0003481)2.07095440
95High anterior hairline (HP:0009890)2.05285108
96Abnormality of the anterior horn cell (HP:0006802)2.04868803
97Degeneration of anterior horn cells (HP:0002398)2.04868803
98Recurrent cutaneous fungal infections (HP:0011370)2.02525418
99Chronic mucocutaneous candidiasis (HP:0002728)2.02525418
100Proximal tubulopathy (HP:0000114)2.01750971
101Medulloblastoma (HP:0002885)2.01585829
102Atelectasis (HP:0100750)2.01328662
103Elfin facies (HP:0004428)2.01004161
104Aplasia/hypoplasia of the humerus (HP:0006507)2.00452872
105Missing ribs (HP:0000921)1.99895113
106Gastrointestinal stroma tumor (HP:0100723)1.99526624
107Abdominal situs inversus (HP:0003363)1.98966519
108Abnormality of abdominal situs (HP:0011620)1.98966519
109Myopathic facies (HP:0002058)1.98768116
110Petechiae (HP:0000967)1.98166816
111Neoplasm of the pancreas (HP:0002894)1.98015602
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.97708739
113Ectopic kidney (HP:0000086)1.97130133
114Abnormality of the renal collecting system (HP:0004742)1.96241686
115Distal lower limb muscle weakness (HP:0009053)1.96163168
116Recurrent viral infections (HP:0004429)1.96074835
117Increased nuchal translucency (HP:0010880)1.95173608
118Stridor (HP:0010307)1.94986597
119Abnormality of the metopic suture (HP:0005556)1.94615360
120Osteomyelitis (HP:0002754)1.94198489
121Episodic fever (HP:0001954)1.93556099
122Purpura (HP:0000979)1.93508120
123Abnormality of the carotid arteries (HP:0005344)1.93183853
124Abnormal sex determination (HP:0012244)1.92988428
125Sex reversal (HP:0012245)1.92988428
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92520586
127Ureteral duplication (HP:0000073)1.90663872
128Emphysema (HP:0002097)1.90621245
129Facial cleft (HP:0002006)1.90305131
130Peritonitis (HP:0002586)1.89936513
131Hypertriglyceridemia (HP:0002155)1.88483962
132Acne (HP:0001061)1.88169873
133Duodenal stenosis (HP:0100867)1.88078355
134Small intestinal stenosis (HP:0012848)1.88078355
135Difficulty climbing stairs (HP:0003551)1.87685648
136Polygenic inheritance (HP:0010982)1.87591981
137Neoplasm of the adrenal cortex (HP:0100641)1.87540394
138Cholecystitis (HP:0001082)1.87532404
139Abnormal gallbladder physiology (HP:0012438)1.87532404
140Abnormality of glycolipid metabolism (HP:0010969)1.87272036
141Abnormality of liposaccharide metabolism (HP:0010968)1.87272036
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.87272036
143Slender long bone (HP:0003100)1.87075444
144Recurrent sinusitis (HP:0011108)1.86820782
145Cerebral aneurysm (HP:0004944)1.86077527
146Intestinal atresia (HP:0011100)1.85999303
147Ventricular tachycardia (HP:0004756)1.85851877
148Amyloidosis (HP:0011034)1.85431091
149Distal lower limb amyotrophy (HP:0008944)1.85430919
150Dysostosis multiplex (HP:0000943)1.85187443
151Reticulocytopenia (HP:0001896)1.84943001
152Keratoconjunctivitis (HP:0001096)1.84325848
153Abnormal vertebral ossification (HP:0100569)1.83454153
154Abnormality of DNA repair (HP:0003254)1.81752439
155Arterial thrombosis (HP:0004420)1.81457779
156Thin bony cortex (HP:0002753)1.80378499
157Optic nerve coloboma (HP:0000588)1.80147855
158Oligodactyly (HP:0012165)1.78778167
159Hyperinsulinemic hypoglycemia (HP:0000825)1.78767208
160Triphalangeal thumb (HP:0001199)1.78595619
161Hemoptysis (HP:0002105)1.78505750
162Rough bone trabeculation (HP:0100670)1.78215304
163Epistaxis (HP:0000421)1.76037480
164Distal upper limb amyotrophy (HP:0007149)1.75778004
165Upper limb amyotrophy (HP:0009129)1.75778004
166Abnormality of iron homeostasis (HP:0011031)1.75500626
167Diaphragmatic weakness (HP:0009113)1.74796375
168Abnormality of the peritoneum (HP:0002585)1.74624103
169Bundle branch block (HP:0011710)1.74563434
170Interstitial pulmonary disease (HP:0006530)1.74347241
171Premature loss of primary teeth (HP:0006323)1.74119296
172Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74045408
173Abnormality of the thoracic spine (HP:0100711)1.73992313
174Renovascular hypertension (HP:0100817)1.72260236
175Intestinal fistula (HP:0100819)1.69572517
176Horseshoe kidney (HP:0000085)1.69428878
177Premature ovarian failure (HP:0008209)1.69358722
178Tracheoesophageal fistula (HP:0002575)1.67987602
179Spina bifida occulta (HP:0003298)1.67012131
180Supernumerary ribs (HP:0005815)1.66756018
181Abnormality of the duodenum (HP:0002246)1.66739844
18211 pairs of ribs (HP:0000878)1.64777912
183Short thumb (HP:0009778)1.63552240
184Hemivertebrae (HP:0002937)1.63396697
185Abnormality of chromosome stability (HP:0003220)1.62834750
186Vertebral fusion (HP:0002948)1.62268935
187Astrocytoma (HP:0009592)1.62231891
188Abnormality of the astrocytes (HP:0100707)1.62231891
189Trigonocephaly (HP:0000243)1.61817064
190Spinal muscular atrophy (HP:0007269)1.60359891
191Hypoplasia of the radius (HP:0002984)1.60087984
192Short humerus (HP:0005792)1.59273913
193Pendular nystagmus (HP:0012043)1.58684732
194Colon cancer (HP:0003003)1.57972034
195Bilateral microphthalmos (HP:0007633)1.57804865
196Long eyelashes (HP:0000527)1.56951570
197Late onset (HP:0003584)1.56654383
198Long palpebral fissure (HP:0000637)1.56575014
199Rectal fistula (HP:0100590)1.56458992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.88882216
2IRAK33.61836730
3PRPF4B3.19772460
4SMG13.04728100
5RIPK43.00511623
6EPHA22.95528553
7ZAK2.87735423
8PLK42.80109683
9MAP4K12.78516992
10TTK2.73177933
11MAP2K32.51318116
12CDK122.45819913
13PASK2.41271776
14IRAK22.31134477
15MAPK152.28557673
16WEE12.19169156
17ICK2.11507646
18NEK22.10233736
19MARK12.07924437
20TNK22.06036305
21DYRK32.05500800
22BRD41.98381023
23STK38L1.93795221
24STK161.92896654
25EPHB11.85690148
26CDC71.78534683
27MAP3K101.78121793
28MAP3K31.75822461
29TYK21.68407109
30CSK1.64349768
31PLK11.54014019
32BLK1.51979626
33MARK21.51815501
34CHEK21.48264922
35TRIB31.47954770
36CDK71.43932643
37SIK21.41500248
38IRAK11.41326313
39PAK41.39736459
40ATR1.38406306
41GRK61.38238715
42LATS21.37125435
43PRKCI1.36995552
44CDC42BPA1.35540661
45KSR21.34508211
46PRKD31.34273362
47NEK11.34117528
48MAP3K11.33904727
49MAP3K131.33158753
50WNK31.32765738
51PTK61.31072315
52TBK11.28452388
53ZAP701.25677085
54FES1.25215778
55SRPK11.22159447
56MAP3K111.21621836
57PINK11.17063720
58MTOR1.12531530
59FGFR41.12434276
60TESK21.12080454
61AKT31.11679307
62TAOK11.08249560
63BCKDK1.07924706
64BTK1.07524459
65MAP2K21.03844064
66JAK31.03215756
67PDPK11.02374089
68CHEK11.01827229
69AURKA1.01653098
70HCK1.00821848
71IRAK40.99526956
72MAP3K70.94854456
73AURKB0.92408499
74FGR0.89990409
75EEF2K0.89802947
76RPS6KB20.88908208
77EPHB20.86938124
78TSSK60.85537402
79BRSK10.85533093
80MAP3K140.85067407
81CDK40.83850800
82RPS6KC10.83729370
83RPS6KL10.83729370
84PRKD20.83435186
85RPS6KA20.82526715
86STK380.81902095
87BRSK20.79858635
88IKBKE0.79768744
89BMX0.79702335
90BRAF0.78762283
91PDGFRA0.77046959
92MAP3K80.76864305
93LATS10.76210230
94CDK20.75350844
95PDK10.74657669
96LRRK20.73321466
97PKN20.71507201
98INSRR0.71467241
99DYRK1B0.70599587
100RIPK10.69599450
101TAOK20.69139656
102SIK10.68902615
103UHMK10.67602353
104AKT20.67288630
105PHKG10.66844461
106PHKG20.66844461
107RPS6KA60.66253131
108JAK20.65772243
109CSF1R0.63222182
110PLK30.63184835
111CAMK1D0.62954880
112ATM0.62948030
113SYK0.61719221
114TTN0.60393032
115HIPK20.60115656
116MAPK120.59533658
117MAP3K60.58624698
118LYN0.58174389
119MATK0.57775592
120MAPKAPK30.57497325
121CDK190.56814318
122TESK10.55954713
123NME20.55371801
124MAPK110.55086424
125MARK30.54497488
126CDK10.53792213
127PRKG20.52314209
128IKBKB0.51340218
129DYRK20.51128466
130FLT30.49492207
131ERN10.48896166
132STK100.48723359
133LCK0.47618132
134CAMKK10.47522737
135SGK30.46948460
136RPS6KA10.46358675
137RPS6KA40.44665631
138PAK10.44634878
139JAK10.44156690
140STK110.43515408
141MAPK70.43084653
142DMPK0.41902925
143CSNK1E0.41556548
144ACVR1B0.40486050
145KSR10.40410227
146ERBB20.40374808
147PTK2B0.39926230
148MAPKAPK20.39527086
149PTK20.39448840
150STK40.38367039
151TYRO30.38252010
152PRKDC0.37659368
153ITK0.37531745
154PRKCH0.36796651
155RET0.36242190
156EIF2AK10.35574644
157ALK0.35230762
158SIK30.34629586
159AKT10.34417203
160LMTK20.33806251
161CHUK0.32871889
162GSK3B0.32397730
163MAPK90.31715868
164MAPK140.31341714

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.12851738
2Mismatch repair_Homo sapiens_hsa034303.57363511
3Spliceosome_Homo sapiens_hsa030403.20956883
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97691142
5RNA polymerase_Homo sapiens_hsa030202.95770020
6Base excision repair_Homo sapiens_hsa034102.89176631
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.84511652
8RNA transport_Homo sapiens_hsa030132.82632740
9Fanconi anemia pathway_Homo sapiens_hsa034602.61098970
10Homologous recombination_Homo sapiens_hsa034402.52456528
11Cell cycle_Homo sapiens_hsa041102.50040107
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47639003
13Osteoclast differentiation_Homo sapiens_hsa043802.42347428
14mRNA surveillance pathway_Homo sapiens_hsa030152.38184109
15Nucleotide excision repair_Homo sapiens_hsa034202.27081582
16B cell receptor signaling pathway_Homo sapiens_hsa046622.18729805
17Pyrimidine metabolism_Homo sapiens_hsa002402.17816188
18Basal cell carcinoma_Homo sapiens_hsa052172.15751673
19Leishmaniasis_Homo sapiens_hsa051402.12353519
20One carbon pool by folate_Homo sapiens_hsa006702.06063463
21Notch signaling pathway_Homo sapiens_hsa043302.01272583
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01264087
23Other glycan degradation_Homo sapiens_hsa005111.90634022
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85830391
25Hedgehog signaling pathway_Homo sapiens_hsa043401.79697167
26Basal transcription factors_Homo sapiens_hsa030221.73776659
27Ribosome_Homo sapiens_hsa030101.73476413
28p53 signaling pathway_Homo sapiens_hsa041151.72164050
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68962253
30Non-small cell lung cancer_Homo sapiens_hsa052231.64904639
31Malaria_Homo sapiens_hsa051441.61851710
32Tuberculosis_Homo sapiens_hsa051521.60882372
33VEGF signaling pathway_Homo sapiens_hsa043701.57215762
34Hippo signaling pathway_Homo sapiens_hsa043901.56143939
35RNA degradation_Homo sapiens_hsa030181.53180005
36Proteasome_Homo sapiens_hsa030501.52241444
37Staphylococcus aureus infection_Homo sapiens_hsa051501.50317328
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45734436
39Pancreatic cancer_Homo sapiens_hsa052121.40113023
40Lysine degradation_Homo sapiens_hsa003101.39269314
41Influenza A_Homo sapiens_hsa051641.38396330
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38180539
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34059204
44Toxoplasmosis_Homo sapiens_hsa051451.33577190
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.33082634
46Chemokine signaling pathway_Homo sapiens_hsa040621.32192626
47T cell receptor signaling pathway_Homo sapiens_hsa046601.31663120
48Allograft rejection_Homo sapiens_hsa053301.31149386
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30871628
50Measles_Homo sapiens_hsa051621.29185742
51TNF signaling pathway_Homo sapiens_hsa046681.26425637
52Hepatitis C_Homo sapiens_hsa051601.26284883
53Autoimmune thyroid disease_Homo sapiens_hsa053201.24468652
54Purine metabolism_Homo sapiens_hsa002301.24415766
55Graft-versus-host disease_Homo sapiens_hsa053321.22614088
56Hepatitis B_Homo sapiens_hsa051611.20699655
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20188312
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.19867798
59Primary immunodeficiency_Homo sapiens_hsa053401.18926341
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18512787
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.17988128
62Selenocompound metabolism_Homo sapiens_hsa004501.15146354
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14880947
64Viral myocarditis_Homo sapiens_hsa054161.13905637
65Renal cell carcinoma_Homo sapiens_hsa052111.08091384
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06276527
67Apoptosis_Homo sapiens_hsa042101.05854361
68African trypanosomiasis_Homo sapiens_hsa051431.02724809
69Circadian rhythm_Homo sapiens_hsa047101.00011996
70HTLV-I infection_Homo sapiens_hsa051660.98916903
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98752956
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.98275251
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.97310595
74Endocytosis_Homo sapiens_hsa041440.95996222
75Prolactin signaling pathway_Homo sapiens_hsa049170.95624285
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.95604919
77Lysosome_Homo sapiens_hsa041420.94661101
78Sulfur relay system_Homo sapiens_hsa041220.93969601
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93560093
80Fructose and mannose metabolism_Homo sapiens_hsa000510.92328340
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91907121
82Hematopoietic cell lineage_Homo sapiens_hsa046400.91515050
83Antigen processing and presentation_Homo sapiens_hsa046120.90232557
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90086802
85Epstein-Barr virus infection_Homo sapiens_hsa051690.89627066
86Choline metabolism in cancer_Homo sapiens_hsa052310.89456625
87GnRH signaling pathway_Homo sapiens_hsa049120.88163861
88Bladder cancer_Homo sapiens_hsa052190.87558197
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87295522
90Galactose metabolism_Homo sapiens_hsa000520.87287091
91Wnt signaling pathway_Homo sapiens_hsa043100.85933012
92Folate biosynthesis_Homo sapiens_hsa007900.85598471
93Phagosome_Homo sapiens_hsa041450.84946834
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84755854
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.84229371
96Biosynthesis of amino acids_Homo sapiens_hsa012300.84044769
97ErbB signaling pathway_Homo sapiens_hsa040120.83693677
98Salmonella infection_Homo sapiens_hsa051320.82697367
99Oocyte meiosis_Homo sapiens_hsa041140.81239838
100Inositol phosphate metabolism_Homo sapiens_hsa005620.80973139
101Insulin resistance_Homo sapiens_hsa049310.79836086
102Shigellosis_Homo sapiens_hsa051310.79750510
103Arginine and proline metabolism_Homo sapiens_hsa003300.79158625
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.79055504
105MicroRNAs in cancer_Homo sapiens_hsa052060.78811177
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78505101
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78143942
108Legionellosis_Homo sapiens_hsa051340.76325525
109Glioma_Homo sapiens_hsa052140.73932324
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73790718
111Type I diabetes mellitus_Homo sapiens_hsa049400.73100459
112Type II diabetes mellitus_Homo sapiens_hsa049300.72882721
113Amoebiasis_Homo sapiens_hsa051460.72827399
114Adherens junction_Homo sapiens_hsa045200.72192134
115Prion diseases_Homo sapiens_hsa050200.72151552
116Tight junction_Homo sapiens_hsa045300.70938643
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70900388
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69718353
119Pertussis_Homo sapiens_hsa051330.69215425
120Non-homologous end-joining_Homo sapiens_hsa034500.69073027
121Platelet activation_Homo sapiens_hsa046110.68946401
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67900228
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67569479
124Thyroid cancer_Homo sapiens_hsa052160.65961038
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65949832
126N-Glycan biosynthesis_Homo sapiens_hsa005100.64953017
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.64772230
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.64688997
129Estrogen signaling pathway_Homo sapiens_hsa049150.63672634
130MAPK signaling pathway_Homo sapiens_hsa040100.61690098
131HIF-1 signaling pathway_Homo sapiens_hsa040660.59584547
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57779903
133Pentose phosphate pathway_Homo sapiens_hsa000300.56587942
134Vitamin B6 metabolism_Homo sapiens_hsa007500.56344925
135mTOR signaling pathway_Homo sapiens_hsa041500.55921488
136Endometrial cancer_Homo sapiens_hsa052130.55361657
137Viral carcinogenesis_Homo sapiens_hsa052030.55343102
138Acute myeloid leukemia_Homo sapiens_hsa052210.53448928
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52990376
140Colorectal cancer_Homo sapiens_hsa052100.52813717
141Glutathione metabolism_Homo sapiens_hsa004800.52752235
142AMPK signaling pathway_Homo sapiens_hsa041520.52368180
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52016727
144Small cell lung cancer_Homo sapiens_hsa052220.50934553
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50210976
146Carbon metabolism_Homo sapiens_hsa012000.50133826
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.50116393
148Chronic myeloid leukemia_Homo sapiens_hsa052200.49815921
149TGF-beta signaling pathway_Homo sapiens_hsa043500.49144573
150Pathways in cancer_Homo sapiens_hsa052000.47149604
151Regulation of autophagy_Homo sapiens_hsa041400.47118575
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.46463005
153Glucagon signaling pathway_Homo sapiens_hsa049220.43982757
154Insulin signaling pathway_Homo sapiens_hsa049100.43695892
155Herpes simplex infection_Homo sapiens_hsa051680.42119624
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40111220
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.38980777
158Huntingtons disease_Homo sapiens_hsa050160.37886031
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35914765
160Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34800508
161alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32506531
162Fat digestion and absorption_Homo sapiens_hsa049750.31365273
163Insulin secretion_Homo sapiens_hsa049110.28812651
164Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28092095
165Protein digestion and absorption_Homo sapiens_hsa049740.27770175
166Prostate cancer_Homo sapiens_hsa052150.26936764
167Melanogenesis_Homo sapiens_hsa049160.26637646
168Glycosaminoglycan degradation_Homo sapiens_hsa005310.26565731
169Linoleic acid metabolism_Homo sapiens_hsa005910.26499995
170Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25784576
171Dilated cardiomyopathy_Homo sapiens_hsa054140.25634957
172FoxO signaling pathway_Homo sapiens_hsa040680.25582320
173Melanoma_Homo sapiens_hsa052180.24564055
174Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24488975
175Arachidonic acid metabolism_Homo sapiens_hsa005900.23399763
176Cardiac muscle contraction_Homo sapiens_hsa042600.22964508

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