MED22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.41909525
2nuclear pore organization (GO:0006999)5.63949068
3response to misfolded protein (GO:0051788)5.47933496
4misfolded or incompletely synthesized protein catabolic process (GO:0006515)5.08676833
5DNA unwinding involved in DNA replication (GO:0006268)4.95351167
6cellular protein complex localization (GO:0034629)4.94663490
7folic acid-containing compound biosynthetic process (GO:0009396)4.84780540
8pore complex assembly (GO:0046931)4.83423816
9glycoprotein catabolic process (GO:0006516)4.72083893
10protein complex localization (GO:0031503)4.63862124
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.62508561
12peptidyl-arginine omega-N-methylation (GO:0035247)4.32614424
13negative regulation of RNA splicing (GO:0033119)4.25923146
14Golgi transport vesicle coating (GO:0048200)4.25560185
15COPI coating of Golgi vesicle (GO:0048205)4.25560185
16histone arginine methylation (GO:0034969)4.21973981
17proline biosynthetic process (GO:0006561)4.14361881
18localization within membrane (GO:0051668)3.98658972
193-UTR-mediated mRNA stabilization (GO:0070935)3.89048597
20regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.83324497
21apoptotic process involved in morphogenesis (GO:0060561)3.82769631
22negative regulation of mRNA processing (GO:0050686)3.77315486
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.74508584
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73135878
25mitotic chromosome condensation (GO:0007076)3.71413561
26pre-miRNA processing (GO:0031054)3.69826398
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67027149
28intracellular estrogen receptor signaling pathway (GO:0030520)3.56726522
29histone H2A monoubiquitination (GO:0035518)3.56301998
30folic acid metabolic process (GO:0046655)3.55773384
31RNA stabilization (GO:0043489)3.51424663
32mRNA stabilization (GO:0048255)3.51424663
33DNA deamination (GO:0045006)3.51181449
34peptidyl-arginine methylation (GO:0018216)3.46401795
35peptidyl-arginine N-methylation (GO:0035246)3.46401795
36tooth mineralization (GO:0034505)3.46305781
37negative regulation of mRNA metabolic process (GO:1903312)3.44465540
38protein-DNA complex disassembly (GO:0032986)3.44104931
39nucleosome disassembly (GO:0006337)3.44104931
40L-serine metabolic process (GO:0006563)3.39610269
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37394967
42ribosomal small subunit biogenesis (GO:0042274)3.35777326
43base-excision repair, AP site formation (GO:0006285)3.32737953
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32504592
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32504592
46pteridine-containing compound biosynthetic process (GO:0042559)3.29685570
47modulation by virus of host process (GO:0019054)3.28448101
48DNA strand elongation involved in DNA replication (GO:0006271)3.28236961
49synapsis (GO:0007129)3.24999732
50epithelial cell differentiation involved in prostate gland development (GO:0060742)3.19444359
51DNA strand elongation (GO:0022616)3.17283486
52ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.14455796
53negative regulation of cell size (GO:0045792)3.13745459
54mitochondrial fusion (GO:0008053)3.11904351
55regulation of NFAT protein import into nucleus (GO:0051532)3.10353546
56protein localization to kinetochore (GO:0034501)3.09401602
57positive regulation of nuclease activity (GO:0032075)3.09269103
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.06377238
59protein deneddylation (GO:0000338)3.05039116
60histone-serine phosphorylation (GO:0035404)3.03687311
61formation of translation preinitiation complex (GO:0001731)3.03148602
62regulation of translational termination (GO:0006449)3.02696635
63proline metabolic process (GO:0006560)3.02680581
64regulation of sister chromatid cohesion (GO:0007063)2.98492615
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97357993
66mannose metabolic process (GO:0006013)2.94933798
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94510547
68DNA replication initiation (GO:0006270)2.94124408
69glycine metabolic process (GO:0006544)2.93102133
70negative regulation of erythrocyte differentiation (GO:0045647)2.91361751
71one-carbon metabolic process (GO:0006730)2.87949478
72DNA replication-dependent nucleosome organization (GO:0034723)2.87526783
73DNA replication-dependent nucleosome assembly (GO:0006335)2.87526783
74focal adhesion assembly (GO:0048041)2.85195804
75cell-substrate adherens junction assembly (GO:0007045)2.85195804
76regulation of posttranscriptional gene silencing (GO:0060147)2.84387884
77regulation of gene silencing by miRNA (GO:0060964)2.84387884
78regulation of gene silencing by RNA (GO:0060966)2.84387884
79mitotic nuclear envelope disassembly (GO:0007077)2.83981986
80convergent extension (GO:0060026)2.83270061
81DNA replication checkpoint (GO:0000076)2.82350873
82modulation by symbiont of host cellular process (GO:0044068)2.81657551
83adherens junction assembly (GO:0034333)2.78543705
84regulation of hippo signaling (GO:0035330)2.78488430
85viral mRNA export from host cell nucleus (GO:0046784)2.77779247
86regulation of nuclease activity (GO:0032069)2.77556272
87tetrahydrofolate metabolic process (GO:0046653)2.76911933
88DNA duplex unwinding (GO:0032508)2.76380621
89cellular response to topologically incorrect protein (GO:0035967)2.74772130
90positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.72978740
91chromatin assembly (GO:0031497)2.72089777
92serine family amino acid biosynthetic process (GO:0009070)2.72020363
93dosage compensation (GO:0007549)2.71937883
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70855409
95negative regulation of histone methylation (GO:0031061)2.70576160
96activation of Rac GTPase activity (GO:0032863)2.70335672
97nuclear envelope organization (GO:0006998)2.67651324
98spliceosomal complex assembly (GO:0000245)2.67188927
99positive regulation by symbiont of host defense response (GO:0052509)2.65757797
100modulation by symbiont of host defense response (GO:0052031)2.65757797
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65757797
102modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65757797
103positive regulation by organism of defense response of other organism involved in symbiotic interact2.65757797
104modulation by symbiont of host immune response (GO:0052553)2.65757797
105modulation by virus of host morphology or physiology (GO:0019048)2.64444305
106membrane disassembly (GO:0030397)2.64391403
107nuclear envelope disassembly (GO:0051081)2.64391403
108ncRNA 3-end processing (GO:0043628)2.63853413
109mismatch repair (GO:0006298)2.63583203
110NADPH regeneration (GO:0006740)2.62027115
111apoptotic process involved in development (GO:1902742)2.61604748
112sister chromatid segregation (GO:0000819)2.60493599
113cellular response to virus (GO:0098586)2.60460013
114L-alpha-amino acid transmembrane transport (GO:1902475)2.60208779
115protein targeting to vacuole (GO:0006623)2.59785759
116protein targeting to lysosome (GO:0006622)2.59785759
117establishment of protein localization to vacuole (GO:0072666)2.59785759
118regulation of mRNA stability (GO:0043488)2.59232515
119negative regulation of gene expression, epigenetic (GO:0045814)2.58690742
120histone H3-K36 demethylation (GO:0070544)2.58620996
121lysine catabolic process (GO:0006554)2.57494285
122lysine metabolic process (GO:0006553)2.57494285
123positive regulation of histone deacetylation (GO:0031065)2.57379623
124heterochromatin organization (GO:0070828)2.56673803
125folic acid-containing compound metabolic process (GO:0006760)2.56412561
126endoplasmic reticulum unfolded protein response (GO:0030968)2.55901562
127DNA geometric change (GO:0032392)2.54372469
128endosome to melanosome transport (GO:0035646)2.52769035
129endosome to pigment granule transport (GO:0043485)2.52769035
130mitotic sister chromatid segregation (GO:0000070)2.52388045
131thymic T cell selection (GO:0045061)2.51759608
132regulation of RNA stability (GO:0043487)2.51345309
133protein localization to chromosome, centromeric region (GO:0071459)2.51121332
134translesion synthesis (GO:0019985)2.50777100
135protein localization to endosome (GO:0036010)2.50200840
136histone H2A ubiquitination (GO:0033522)2.50059325
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49246161
1384-hydroxyproline metabolic process (GO:0019471)2.49012330
139snRNA metabolic process (GO:0016073)2.48968755
140protein K11-linked ubiquitination (GO:0070979)2.48268055
141embryonic process involved in female pregnancy (GO:0060136)2.48219068
142glucose catabolic process (GO:0006007)2.47968223
143telomere maintenance via semi-conservative replication (GO:0032201)2.47474174
144regulation of early endosome to late endosome transport (GO:2000641)2.46516304
145semaphorin-plexin signaling pathway (GO:0071526)2.46315324
146rRNA transcription (GO:0009303)2.46017995
147maternal placenta development (GO:0001893)2.45129895
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.45034313
149pentose-phosphate shunt (GO:0006098)2.44705722
150cellular response to unfolded protein (GO:0034620)2.44371675
151cellular response to epidermal growth factor stimulus (GO:0071364)2.44157301
152nucleobase biosynthetic process (GO:0046112)2.43928131
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.43326373
154base-excision repair (GO:0006284)2.43170994
155positive regulation of gene expression, epigenetic (GO:0045815)2.43092621
156negative regulation of viral release from host cell (GO:1902187)2.43055999
157regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.41890276
158chromosome condensation (GO:0030261)2.41793552
159maturation of SSU-rRNA (GO:0030490)2.41323309
160positive regulation of protein sumoylation (GO:0033235)2.41013976
161viral transcription (GO:0019083)2.40434179
162GDP-mannose metabolic process (GO:0019673)2.40337265
163chromatin silencing (GO:0006342)2.40300585
164mitotic G1 DNA damage checkpoint (GO:0031571)2.40238352
165positive regulation of triglyceride biosynthetic process (GO:0010867)2.40209038
166negative regulation of DNA-templated transcription, elongation (GO:0032785)2.40180897
167peptidyl-lysine dimethylation (GO:0018027)2.37323101
168regulation of oxidative stress-induced neuron death (GO:1903203)2.36102048
169response to topologically incorrect protein (GO:0035966)2.34982718
170ER-nucleus signaling pathway (GO:0006984)2.34899334
171ribosomal small subunit assembly (GO:0000028)2.34781563
172glucocorticoid receptor signaling pathway (GO:0042921)2.34700059
173regulation of translational fidelity (GO:0006450)2.32459642
174regulation of chromatin binding (GO:0035561)2.31801978
175regulation of DNA damage checkpoint (GO:2000001)2.30356186
176pteridine-containing compound metabolic process (GO:0042558)2.27249229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.10730678
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96517980
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62562026
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20990046
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.19986288
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91348661
7MYC_22102868_ChIP-Seq_BL_Human2.56923754
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36760531
9CLOCK_20551151_ChIP-Seq_293T_Human2.31968644
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25604832
11* XRN2_22483619_ChIP-Seq_HELA_Human2.20736146
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18244247
13CIITA_25753668_ChIP-Seq_RAJI_Human2.16405217
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13052671
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11515185
16AR_21909140_ChIP-Seq_LNCAP_Human2.08678413
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05669127
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98934245
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.97332198
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93984810
21ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92583743
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91379943
23KDM2B_26808549_Chip-Seq_DND41_Human1.91225032
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87716688
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86658026
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82860374
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.81298211
28DCP1A_22483619_ChIP-Seq_HELA_Human1.77693433
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76163887
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75728818
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.74125208
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73308350
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73153011
34* GABP_19822575_ChIP-Seq_HepG2_Human1.72965359
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.71005829
36ZNF263_19887448_ChIP-Seq_K562_Human1.68978713
37P68_20966046_ChIP-Seq_HELA_Human1.68821649
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68743380
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67329109
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66381206
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57452471
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57200739
43VDR_21846776_ChIP-Seq_THP-1_Human1.56409171
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.55247083
45KDM5A_27292631_Chip-Seq_BREAST_Human1.54414465
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54296914
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53599082
48KDM2B_26808549_Chip-Seq_K562_Human1.50039708
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49979715
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44859425
51MAF_26560356_Chip-Seq_TH1_Human1.44711976
52MAF_26560356_Chip-Seq_TH2_Human1.44593409
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44279246
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42922879
55* TTF2_22483619_ChIP-Seq_HELA_Human1.40409896
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39891517
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39365640
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.38816327
59VDR_24763502_ChIP-Seq_THP-1_Human1.36807463
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36030474
61SMC4_20622854_ChIP-Seq_HELA_Human1.35198336
62VDR_23849224_ChIP-Seq_CD4+_Human1.34964830
63CHD1_26751641_Chip-Seq_LNCaP_Human1.34738892
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34559565
65UTX_26944678_Chip-Seq_JUKART_Human1.31943580
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30995220
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30854265
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.30707589
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30190109
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30032741
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29194831
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.28915944
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28087300
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27341314
75* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26929369
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26496651
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25679926
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.25082466
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22836472
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22092817
81* FOXP3_21729870_ChIP-Seq_TREG_Human1.20803617
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20596677
83ATF3_27146783_Chip-Seq_COLON_Human1.20580411
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19033174
85TFEB_21752829_ChIP-Seq_HELA_Human1.19016965
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18744365
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18211504
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17815651
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17472058
90NCOR1_26117541_ChIP-Seq_K562_Human1.17371050
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17235137
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.16802591
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.15956541
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13423420
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.13290831
96* CREB1_26743006_Chip-Seq_LNCaP_Human1.12836745
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.12812295
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12598294
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12297854
100BCOR_27268052_Chip-Seq_Bcells_Human1.12148216
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11205106
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10552142
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09787249
104PHF8_20622854_ChIP-Seq_HELA_Human1.09728708
105TCF7_22412390_ChIP-Seq_EML_Mouse1.09416860
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.08606925
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08035394
108RACK7_27058665_Chip-Seq_MCF-7_Human1.07541572
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07254688
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06964935
111TP53_22127205_ChIP-Seq_IMR90_Human1.06834561
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06822261
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06453732
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05767792
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05596045
116* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05374395
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05029928
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03953326
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03781142
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03557315
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03259896
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02870712
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01865667
124FOXP1_21924763_ChIP-Seq_HESCs_Human1.01673126
125BCL6_27268052_Chip-Seq_Bcells_Human1.01637184
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01590377
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01059880
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00944076
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99868094
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.99652798
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98956799
132TP63_17297297_ChIP-ChIP_HaCaT_Human0.98615092
133* CTCF_26484167_Chip-Seq_Bcells_Mouse0.98515744
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95723141
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92775221
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92566113
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92405995
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91781173
139KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91637320
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90717539
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90391323
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89583730
143TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89458271
144* LXR_22292898_ChIP-Seq_THP-1_Human0.89048065
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88066778
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88000770
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87675924
148ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87337024
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86705972
150RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85975051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.30721893
2MP0009278_abnormal_bone_marrow3.16253443
3MP0002254_reproductive_system_inflammat2.70501109
4MP0004264_abnormal_extraembryonic_tissu2.68826931
5MP0008260_abnormal_autophagy2.46555262
6MP0009697_abnormal_copulation2.45154784
7MP0003693_abnormal_embryo_hatching2.44258038
8MP0003111_abnormal_nucleus_morphology2.43892225
9MP0010234_abnormal_vibrissa_follicle2.40861485
10MP0004858_abnormal_nervous_system2.34185482
11MP0004957_abnormal_blastocyst_morpholog2.33048573
12MP0001849_ear_inflammation2.32069104
13MP0004233_abnormal_muscle_weight2.29212374
14MP0005220_abnormal_exocrine_pancreas2.23963767
15MP0010094_abnormal_chromosome_stability2.13788384
16MP0001730_embryonic_growth_arrest2.11268148
17MP0003077_abnormal_cell_cycle2.10857447
18MP0003890_abnormal_embryonic-extraembry2.09199661
19MP0002139_abnormal_hepatobiliary_system2.06657557
20MP0000537_abnormal_urethra_morphology2.02095916
21MP0002653_abnormal_ependyma_morphology1.97855528
22MP0010030_abnormal_orbit_morphology1.88023466
23MP0006054_spinal_hemorrhage1.85525966
24MP0005365_abnormal_bile_salt1.84418851
25MP0003566_abnormal_cell_adhesion1.82414715
26MP0005076_abnormal_cell_differentiation1.81966849
27MP0003300_gastrointestinal_ulcer1.78820980
28MP0003123_paternal_imprinting1.76403174
29MP0008438_abnormal_cutaneous_collagen1.70569235
30MP0001348_abnormal_lacrimal_gland1.63211012
31MP0002249_abnormal_larynx_morphology1.60293630
32MP0009053_abnormal_anal_canal1.58995417
33MP0004185_abnormal_adipocyte_glucose1.58939727
34MP0008007_abnormal_cellular_replicative1.55926741
35MP0008932_abnormal_embryonic_tissue1.53531955
36MP0003436_decreased_susceptibility_to1.52518554
37MP0000350_abnormal_cell_proliferation1.48449293
38MP0003718_maternal_effect1.48421130
39MP0005360_urolithiasis1.47857877
40MP0005380_embryogenesis_phenotype1.43465669
41MP0001672_abnormal_embryogenesis/_devel1.43465669
42MP0001666_abnormal_nutrient_absorption1.42014794
43MP0002088_abnormal_embryonic_growth/wei1.40540417
44MP0003984_embryonic_growth_retardation1.39758257
45MP0009840_abnormal_foam_cell1.36363606
46MP0001697_abnormal_embryo_size1.35353717
47MP0003121_genomic_imprinting1.35155960
48MP0000003_abnormal_adipose_tissue1.34979896
49MP0003942_abnormal_urinary_system1.33977998
50MP0010352_gastrointestinal_tract_polyps1.31635468
51MP0000703_abnormal_thymus_morphology1.31603602
52MP0001873_stomach_inflammation1.31302649
53MP0009333_abnormal_splenocyte_physiolog1.30321379
54MP0002080_prenatal_lethality1.28942937
55MP0003119_abnormal_digestive_system1.28881150
56MP0005408_hypopigmentation1.27785341
57MP0005451_abnormal_body_composition1.24805787
58MP0002084_abnormal_developmental_patter1.24238064
59MP0001346_abnormal_lacrimal_gland1.23769758
60MP0003453_abnormal_keratinocyte_physiol1.21656038
61MP0001915_intracranial_hemorrhage1.21612711
62MP0002085_abnormal_embryonic_tissue1.21316946
63MP0005058_abnormal_lysosome_morphology1.20828149
64MP0003763_abnormal_thymus_physiology1.20807821
65MP0004947_skin_inflammation1.18719994
66MP0002697_abnormal_eye_size1.18014101
67MP0002877_abnormal_melanocyte_morpholog1.17812396
68MP0005501_abnormal_skin_physiology1.17429764
69MP0000858_altered_metastatic_potential1.17302420
70MP0003191_abnormal_cellular_cholesterol1.16915220
71MP0001944_abnormal_pancreas_morphology1.16514112
72MP0004197_abnormal_fetal_growth/weight/1.15965584
73MP0003115_abnormal_respiratory_system1.13892850
74MP0005083_abnormal_biliary_tract1.13765310
75MP0005085_abnormal_gallbladder_physiolo1.13472577
76MP0003252_abnormal_bile_duct1.12143828
77MP0009672_abnormal_birth_weight1.11487796
78MP0005670_abnormal_white_adipose1.10090170
79MP0004808_abnormal_hematopoietic_stem1.09564125
80MP0000685_abnormal_immune_system1.09453995
81MP0003283_abnormal_digestive_organ1.09368660
82MP0001727_abnormal_embryo_implantation1.08534176
83MP0001661_extended_life_span1.08474464
84MP0002086_abnormal_extraembryonic_tissu1.08035204
85MP0003943_abnormal_hepatobiliary_system1.04426283
86MP0000678_abnormal_parathyroid_gland1.04197163
87MP0002398_abnormal_bone_marrow1.04074851
88MP0000609_abnormal_liver_physiology1.04040903
89MP0008961_abnormal_basal_metabolism1.03456733
90MP0005275_abnormal_skin_tensile1.00419683
91MP0010307_abnormal_tumor_latency1.00226458
92MP0005023_abnormal_wound_healing0.99841156
93MP0000465_gastrointestinal_hemorrhage0.99220888
94MP0003303_peritoneal_inflammation0.99093835
95MP0000358_abnormal_cell_content/0.98794873
96MP0010329_abnormal_lipoprotein_level0.98686542
97MP0004381_abnormal_hair_follicle0.97827709
98MP0000598_abnormal_liver_morphology0.97577879
99MP0003315_abnormal_perineum_morphology0.96803917
100MP0000733_abnormal_muscle_development0.96058338
101MP0005666_abnormal_adipose_tissue0.95853203
102MP0002089_abnormal_postnatal_growth/wei0.95726757
103MP0002722_abnormal_immune_system0.93105318
104MP0005187_abnormal_penis_morphology0.92942426
105MP0002429_abnormal_blood_cell0.92770033
106MP0002009_preneoplasia0.92074407
107MP0002019_abnormal_tumor_incidence0.90748573
108MP0002796_impaired_skin_barrier0.90628028
109MP0000049_abnormal_middle_ear0.90162010
110MP0003172_abnormal_lysosome_physiology0.89562921
111MP0002098_abnormal_vibrissa_morphology0.89520550
112MP0000428_abnormal_craniofacial_morphol0.89441175
113MP0009931_abnormal_skin_appearance0.89302165
114MP0005257_abnormal_intraocular_pressure0.89244981
115MP0002111_abnormal_tail_morphology0.88603584
116MP0005621_abnormal_cell_physiology0.87747277
117MP0003122_maternal_imprinting0.87427954
118MP0000371_diluted_coat_color0.86940145
119MP0000750_abnormal_muscle_regeneration0.85215438
120MP0005375_adipose_tissue_phenotype0.84847216
121MP0005623_abnormal_meninges_morphology0.84644139
122MP0000462_abnormal_digestive_system0.83678462
123MP0003329_amyloid_beta_deposits0.82643280
124MP0000579_abnormal_nail_morphology0.82032905
125MP0005332_abnormal_amino_acid0.81188729
126MP0000534_abnormal_ureter_morphology0.80943834
127MP0002932_abnormal_joint_morphology0.80526871
128MP0000490_abnormal_crypts_of0.80449703
129MP0002396_abnormal_hematopoietic_system0.79681386
130MP0003878_abnormal_ear_physiology0.79492535
131MP0005377_hearing/vestibular/ear_phenot0.79492535
132MP0000716_abnormal_immune_system0.78951867
133MP0010368_abnormal_lymphatic_system0.78420022
134MP0000689_abnormal_spleen_morphology0.77555943
135MP0004133_heterotaxia0.76805861
136MP0000313_abnormal_cell_death0.76403531
137MP0009643_abnormal_urine_homeostasis0.75591011
138MP0002420_abnormal_adaptive_immunity0.75225143
139MP0001819_abnormal_immune_cell0.75064454
140MP0002116_abnormal_craniofacial_bone0.73885342
141MP0002092_abnormal_eye_morphology0.73854013
142MP0003699_abnormal_female_reproductive0.73144714
143MP0000432_abnormal_head_morphology0.72845790
144MP0000477_abnormal_intestine_morphology0.71790582
145MP0008877_abnormal_DNA_methylation0.71437774
146MP0005384_cellular_phenotype0.71266067
147MP0009703_decreased_birth_body0.71172345
148MP0002135_abnormal_kidney_morphology0.70890645
149MP0000377_abnormal_hair_follicle0.70870839
150MP0003935_abnormal_craniofacial_develop0.69406320

Predicted human phenotypes

RankGene SetZ-score
1Biliary tract neoplasm (HP:0100574)3.74915583
2Cerebral aneurysm (HP:0004944)3.70524564
3Upper motor neuron abnormality (HP:0002127)3.36167086
4IgM deficiency (HP:0002850)3.33368128
5Reticulocytopenia (HP:0001896)3.23096241
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21735689
7Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00986813
8Abnormality of endocrine pancreas physiology (HP:0012093)2.98930161
9Abnormality of the pancreatic islet cells (HP:0006476)2.98930161
10Syringomyelia (HP:0003396)2.92214892
11Spinal cord lesions (HP:0100561)2.92214892
12Protrusio acetabuli (HP:0003179)2.87861358
13Deep venous thrombosis (HP:0002625)2.81119761
14Long palpebral fissure (HP:0000637)2.78648352
15Chromsome breakage (HP:0040012)2.77098604
16Neoplasm of the rectum (HP:0100743)2.76124763
17Selective tooth agenesis (HP:0001592)2.74052351
18Broad face (HP:0000283)2.65793882
19Neoplasm of the pancreas (HP:0002894)2.64983553
20Multiple enchondromatosis (HP:0005701)2.64931224
21Insomnia (HP:0100785)2.64572976
22Abnormal biliary tract morphology (HP:0012440)2.58419025
23Respiratory difficulties (HP:0002880)2.58195703
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49598949
25Hyperacusis (HP:0010780)2.47352969
26Neoplasm of the small intestine (HP:0100833)2.45892262
27Short 4th metacarpal (HP:0010044)2.45015088
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45015088
29Metaphyseal cupping (HP:0003021)2.44468535
30Breast hypoplasia (HP:0003187)2.43447584
31Increased cerebral lipofuscin (HP:0011813)2.43038502
32Renal duplication (HP:0000075)2.42645359
33High anterior hairline (HP:0009890)2.40133160
34Gastrointestinal carcinoma (HP:0002672)2.39721481
35Malignant gastrointestinal tract tumors (HP:0006749)2.39721481
36Disproportionate tall stature (HP:0001519)2.38874247
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38666920
38Abnormal pancreas size (HP:0012094)2.38409803
39Abnormality of DNA repair (HP:0003254)2.37361960
40Patellar aplasia (HP:0006443)2.35858689
41Spastic diplegia (HP:0001264)2.35681695
42Duplication of thumb phalanx (HP:0009942)2.35570052
43Abnormality of the fingertips (HP:0001211)2.34557460
44Long toe (HP:0010511)2.34351245
45High pitched voice (HP:0001620)2.32509851
46Pointed chin (HP:0000307)2.26860414
47Ulnar bowing (HP:0003031)2.26027888
48Aplasia/Hypoplasia of the patella (HP:0006498)2.25938740
49Abnormality of the motor neurons (HP:0002450)2.24104289
50Abnormal neuron morphology (HP:0012757)2.24104289
51Renovascular hypertension (HP:0100817)2.22123862
52Trigonocephaly (HP:0000243)2.21884303
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.20467317
54Turricephaly (HP:0000262)2.19989821
55Thrombocytosis (HP:0001894)2.19261877
56Birth length less than 3rd percentile (HP:0003561)2.18725648
57Patellar dislocation (HP:0002999)2.18707186
58Ankle contracture (HP:0006466)2.16716066
59Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.15500287
60Death in childhood (HP:0003819)2.14618265
61Abnormality of the distal phalanx of the thumb (HP:0009617)2.13153928
62Abnormality of the 4th metacarpal (HP:0010012)2.12759087
63Shallow orbits (HP:0000586)2.12700398
64Spina bifida occulta (HP:0003298)2.12434250
65Personality changes (HP:0000751)2.12187005
66Abnormality of the calcaneus (HP:0008364)2.10279393
67Squamous cell carcinoma (HP:0002860)2.10216957
68Disinhibition (HP:0000734)2.10010484
69Progressive muscle weakness (HP:0003323)2.07452374
70Overriding aorta (HP:0002623)2.07363964
71Ureteral duplication (HP:0000073)2.07144703
72Myopathic facies (HP:0002058)2.06619520
73Wrist flexion contracture (HP:0001239)2.06545520
74Deep palmar crease (HP:0006191)2.05684457
75Radial bowing (HP:0002986)2.04850218
76Increased density of long bones (HP:0006392)2.03832967
77Flat cornea (HP:0007720)2.03258119
78Asymmetry of the thorax (HP:0001555)2.02858965
79Poikiloderma (HP:0001029)2.02572318
80Cervical subluxation (HP:0003308)2.01903513
81Hand muscle atrophy (HP:0009130)2.01590502
82Leiomyosarcoma (HP:0100243)2.00421671
83Uterine leiomyosarcoma (HP:0002891)2.00421671
84Premature rupture of membranes (HP:0001788)2.00318626
85Cortical dysplasia (HP:0002539)1.99853417
86Bicuspid aortic valve (HP:0001647)1.98164357
87Colitis (HP:0002583)1.97261620
88Agnosia (HP:0010524)1.95964589
89Slender long bone (HP:0003100)1.95775995
90Synostosis of carpal bones (HP:0005048)1.95511996
91Long eyelashes (HP:0000527)1.94802383
92Uterine neoplasm (HP:0010784)1.94058626
93Diminished motivation (HP:0000745)1.94041198
94Abnormal cartilage morphology (HP:0002763)1.92831100
95Abnormality of sulfur amino acid metabolism (HP:0004339)1.92345869
96Stridor (HP:0010307)1.91771170
97Arnold-Chiari malformation (HP:0002308)1.90759593
98Broad distal phalanx of finger (HP:0009836)1.90703421
99Abnormality of the intrinsic pathway (HP:0010989)1.90585995
100Abnormality of the thoracic spine (HP:0100711)1.86718783
101Late onset (HP:0003584)1.86508869
102Ectopic kidney (HP:0000086)1.86351278
103Megalocornea (HP:0000485)1.86164968
104Bladder diverticulum (HP:0000015)1.85822861
105Pseudobulbar signs (HP:0002200)1.85709238
106Hallux valgus (HP:0001822)1.85559744
107Ragged-red muscle fibers (HP:0003200)1.85273497
108Horseshoe kidney (HP:0000085)1.85260224
109Biconcave vertebral bodies (HP:0004586)1.85129414
110Mesangial abnormality (HP:0001966)1.85104670
111Cellulitis (HP:0100658)1.84417888
112Pancreatic islet-cell hyperplasia (HP:0004510)1.83779215
113Male infertility (HP:0003251)1.83760699
114Fatigue (HP:0012378)1.83722373
115Elfin facies (HP:0004428)1.83712234
116Atresia of the external auditory canal (HP:0000413)1.82812675
117Rough bone trabeculation (HP:0100670)1.82579365
118Broad thumb (HP:0011304)1.82000730
119Abnormality of reticulocytes (HP:0004312)1.81951424
120Upper limb amyotrophy (HP:0009129)1.81538643
121Distal upper limb amyotrophy (HP:0007149)1.81538643
122Ovarian neoplasm (HP:0100615)1.81524364
123Duplicated collecting system (HP:0000081)1.81171185
124Abnormal vertebral ossification (HP:0100569)1.80642506
125Deviation of the hallux (HP:0010051)1.80390021
126Aortic aneurysm (HP:0004942)1.79720508
127IgA deficiency (HP:0002720)1.79066961
128Nonimmune hydrops fetalis (HP:0001790)1.77751011
129Neoplasm of the colon (HP:0100273)1.77332827
130Abnormal number of erythroid precursors (HP:0012131)1.75978573
131Genu recurvatum (HP:0002816)1.75184383
132Short 1st metacarpal (HP:0010034)1.74662960
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74662960
134Aortic dissection (HP:0002647)1.74200905
135Mitral valve prolapse (HP:0001634)1.73931052
136Degeneration of anterior horn cells (HP:0002398)1.73599787
137Abnormality of the anterior horn cell (HP:0006802)1.73599787
138Split foot (HP:0001839)1.73410219
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73260922
140Abnormal number of incisors (HP:0011064)1.73089512
141Abnormality of the phalanges of the hallux (HP:0010057)1.72907481
142Hypercalcemia (HP:0003072)1.72709692
143Microvesicular hepatic steatosis (HP:0001414)1.72504497
144Increased nuchal translucency (HP:0010880)1.72352754
145Sandal gap (HP:0001852)1.71149566
146Abnormality of cells of the erythroid lineage (HP:0012130)1.70982360
147Hypertensive crisis (HP:0100735)1.70893864
148Bronchomalacia (HP:0002780)1.70768372
149Persistence of primary teeth (HP:0006335)1.70095626
150Thin ribs (HP:0000883)1.69134806
151Abnormal foot bone ossification (HP:0010675)1.66730038
152Hypochromic anemia (HP:0001931)1.66235729
153Transitional cell carcinoma of the bladder (HP:0006740)1.66181685
154Precocious puberty (HP:0000826)1.65949054
155Glossoptosis (HP:0000162)1.65678847
156Partial duplication of thumb phalanx (HP:0009944)1.63217190
157Partial duplication of the phalanx of hand (HP:0009999)1.62479741
158Abnormality of pyrimidine metabolism (HP:0004353)1.62434320
159Choanal stenosis (HP:0000452)1.62049527
160Optic nerve coloboma (HP:0000588)1.61597571
161Abnormality of the carotid arteries (HP:0005344)1.61191897
162Short thumb (HP:0009778)1.60636229
163Intestinal fistula (HP:0100819)1.60529054
164Absent radius (HP:0003974)1.59322692
165Sparse lateral eyebrow (HP:0005338)1.59295839
166Abnormality of the columella (HP:0009929)1.58939480
167Broad phalanges of the hand (HP:0009768)1.58604799
168Trismus (HP:0000211)1.56082273
169Thoracic kyphosis (HP:0002942)1.55966939
170Deviation of the thumb (HP:0009603)1.55499974
171Gastrointestinal inflammation (HP:0004386)1.55471579
172Tracheoesophageal fistula (HP:0002575)1.55243383
173Proximal placement of thumb (HP:0009623)1.54848106
174Pallor (HP:0000980)1.53054982
175Flared metaphyses (HP:0003015)1.52977608
176Abnormality of the distal phalanges of the toes (HP:0010182)1.52045405
177Difficulty climbing stairs (HP:0003551)1.51631877
178Bowed forearm bones (HP:0003956)1.51617468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.66511746
2SMG14.65542977
3PASK3.89518628
4EEF2K3.81146821
5MAP4K13.09936937
6ICK3.02125435
7PKN23.01162257
8LATS12.88292003
9ACVR1B2.76269891
10PRPF4B2.53207979
11PLK42.48244231
12TAOK32.48083420
13ERN12.33404332
14MAP3K102.01378537
15IRAK32.00935022
16TGFBR11.94768021
17EIF2AK31.90974002
18BRSK11.87238022
19MAP3K111.81691414
20TTK1.81087197
21TYRO31.77732903
22TTN1.75483764
23NEK11.74620959
24MAP2K31.74239211
25FGFR41.73168044
26PDGFRA1.71526876
27NEK21.67541712
28PTK61.64547709
29PAK41.62618964
30LRRK21.58244384
31RPS6KB21.57056810
32CDC71.56691619
33TESK21.55471441
34LATS21.55186928
35CAMK1D1.45360481
36IRAK41.42364240
37PRKD21.41711042
38FLT31.40004169
39BRSK21.39045908
40IRAK21.36231436
41SCYL21.33882406
42TAOK11.20642705
43MARK21.20107342
44VRK21.19604673
45BUB11.19017778
46MAPKAPK31.17874331
47CCNB11.17019292
48DYRK31.16532157
49STK101.10292820
50TSSK61.08333621
51BCKDK1.08184292
52RPS6KC11.04843668
53RPS6KL11.04843668
54NME21.02520067
55SRPK11.01788630
56SIK11.00440435
57PLK10.99040198
58BMX0.98157037
59CDC42BPA0.93721842
60KSR10.92442990
61PAK20.91773411
62SIK20.90873119
63EPHA20.90839767
64TGFBR20.90490718
65RPS6KA60.90089944
66AURKB0.89912939
67RPS6KA40.88573381
68MAP3K80.86869724
69WEE10.83261514
70CDK40.83053979
71TESK10.82354721
72MTOR0.82317296
73FGFR20.79965910
74MELK0.79315035
75RIPK40.76792828
76ZAP700.76603574
77TNK20.76279753
78DDR20.75082632
79STK38L0.74639132
80PLK30.73624489
81MAPK110.70729155
82STK30.69568900
83MAP2K10.68388638
84CDK60.67496845
85ILK0.67228825
86BLK0.65124720
87CAMKK10.64637207
88MAP2K20.63701959
89FGFR10.63469816
90HIPK20.63281364
91DYRK1B0.62706647
92MAP3K60.62469511
93DYRK20.62408415
94RPS6KA10.62333992
95VRK10.62328612
96CDK120.62271088
97MOS0.61695935
98TAOK20.60868269
99PRKD30.60855574
100CHEK10.60618693
101PTK20.59999530
102ERBB40.58056186
103UHMK10.56721658
104GRK60.55573706
105CAMK1G0.55492019
106NTRK20.54964384
107BMPR1B0.54813013
108PRKCI0.54763682
109ATR0.54369007
110BTK0.53823367
111JAK30.52472443
112MAP3K70.52043088
113IRAK10.50803654
114PDPK10.50756186
115NME10.49409288
116PAK10.47002038
117CSF1R0.46537327
118TBK10.45725284
119TLK10.45164232
120CDK80.45130763
121SIK30.44919204
122RPS6KA20.44531052
123FER0.44299491
124ALK0.43881047
125AURKA0.40887864
126TAF10.40789819
127AKT20.40224231
128AKT10.40051922
129MAP3K10.39455653
130CHEK20.38555373
131PIM10.37637555
132PDGFRB0.36902788
133KSR20.36502924
134FGR0.34857001
135EPHB20.34572146
136CDK20.34234427
137CDK70.33999392
138BRAF0.33950799
139MAP3K130.33289403
140MAPKAPK20.32809285
141MAP3K30.32510184
142CDK10.30003767
143TYK20.29759677
144NUAK10.28968534
145KDR0.27478977
146NEK90.27202150
147LIMK10.26132428
148RET0.25081387
149EPHA30.24568727
150PAK30.23768398
151EPHB10.22669556

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.40397617
2Mismatch repair_Homo sapiens_hsa034303.09868542
3N-Glycan biosynthesis_Homo sapiens_hsa005102.45893877
4One carbon pool by folate_Homo sapiens_hsa006702.42284917
5RNA transport_Homo sapiens_hsa030132.36343779
6Selenocompound metabolism_Homo sapiens_hsa004502.31882432
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24982895
8Base excision repair_Homo sapiens_hsa034102.22648252
9Cell cycle_Homo sapiens_hsa041102.19389865
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19227960
11Folate biosynthesis_Homo sapiens_hsa007902.12770112
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06626352
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04382475
14Spliceosome_Homo sapiens_hsa030401.97956292
15Acute myeloid leukemia_Homo sapiens_hsa052211.86938021
16Biosynthesis of amino acids_Homo sapiens_hsa012301.80112301
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78892280
18RNA polymerase_Homo sapiens_hsa030201.73484996
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64021163
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58545825
21Other glycan degradation_Homo sapiens_hsa005111.58461106
22B cell receptor signaling pathway_Homo sapiens_hsa046621.55462128
23Pyruvate metabolism_Homo sapiens_hsa006201.52897043
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52702918
25Fatty acid degradation_Homo sapiens_hsa000711.47139643
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.44205202
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43914246
28mRNA surveillance pathway_Homo sapiens_hsa030151.43334999
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41094071
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.38990710
31RNA degradation_Homo sapiens_hsa030181.38603268
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38549214
33Thyroid cancer_Homo sapiens_hsa052161.36108521
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36067950
35Pyrimidine metabolism_Homo sapiens_hsa002401.34838632
36VEGF signaling pathway_Homo sapiens_hsa043701.29386083
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29371378
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.28401177
39Sulfur relay system_Homo sapiens_hsa041221.22030647
40Proteasome_Homo sapiens_hsa030501.18533671
41Carbon metabolism_Homo sapiens_hsa012001.16198233
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15452167
43Fatty acid metabolism_Homo sapiens_hsa012121.13930856
44Prostate cancer_Homo sapiens_hsa052151.13303331
45Apoptosis_Homo sapiens_hsa042101.10592101
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.10430549
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.08666982
48Chronic myeloid leukemia_Homo sapiens_hsa052201.08488236
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08414239
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06393144
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.06192529
52Hepatitis B_Homo sapiens_hsa051611.05620771
53Galactose metabolism_Homo sapiens_hsa000521.05007528
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02549323
55Bladder cancer_Homo sapiens_hsa052191.01127610
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01116297
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00780037
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00428344
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97867023
60Osteoclast differentiation_Homo sapiens_hsa043800.97351940
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96867906
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93554001
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.91471596
64Small cell lung cancer_Homo sapiens_hsa052220.90956197
65Renal cell carcinoma_Homo sapiens_hsa052110.90565997
66Vitamin B6 metabolism_Homo sapiens_hsa007500.89862898
67Lysine degradation_Homo sapiens_hsa003100.86734145
68Arginine and proline metabolism_Homo sapiens_hsa003300.84437422
69ErbB signaling pathway_Homo sapiens_hsa040120.82862980
70Herpes simplex infection_Homo sapiens_hsa051680.82839876
71mTOR signaling pathway_Homo sapiens_hsa041500.82027487
72MicroRNAs in cancer_Homo sapiens_hsa052060.81708536
73Sulfur metabolism_Homo sapiens_hsa009200.81291806
74Pancreatic cancer_Homo sapiens_hsa052120.80976637
75Fanconi anemia pathway_Homo sapiens_hsa034600.80267295
76Tryptophan metabolism_Homo sapiens_hsa003800.79945335
77Hepatitis C_Homo sapiens_hsa051600.79639378
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.78960876
79Colorectal cancer_Homo sapiens_hsa052100.78419908
80Hippo signaling pathway_Homo sapiens_hsa043900.78373738
81Lysosome_Homo sapiens_hsa041420.78102481
82T cell receptor signaling pathway_Homo sapiens_hsa046600.77963997
83Nucleotide excision repair_Homo sapiens_hsa034200.77842000
84Propanoate metabolism_Homo sapiens_hsa006400.75506932
85Ribosome_Homo sapiens_hsa030100.75174694
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75060423
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74432417
88Fat digestion and absorption_Homo sapiens_hsa049750.73780052
89GnRH signaling pathway_Homo sapiens_hsa049120.73410321
90Notch signaling pathway_Homo sapiens_hsa043300.73046767
91p53 signaling pathway_Homo sapiens_hsa041150.72759134
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.72660048
93Primary immunodeficiency_Homo sapiens_hsa053400.71816973
94Glioma_Homo sapiens_hsa052140.70364440
95Choline metabolism in cancer_Homo sapiens_hsa052310.68997667
96Oocyte meiosis_Homo sapiens_hsa041140.68746223
97Fructose and mannose metabolism_Homo sapiens_hsa000510.67771579
98Adherens junction_Homo sapiens_hsa045200.66866896
99PPAR signaling pathway_Homo sapiens_hsa033200.66554917
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66069446
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65998246
102Prolactin signaling pathway_Homo sapiens_hsa049170.65957467
103TNF signaling pathway_Homo sapiens_hsa046680.65570720
104Pathways in cancer_Homo sapiens_hsa052000.64800191
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.64109166
106Viral carcinogenesis_Homo sapiens_hsa052030.63110551
107Butanoate metabolism_Homo sapiens_hsa006500.62570514
108Melanoma_Homo sapiens_hsa052180.62566295
109Influenza A_Homo sapiens_hsa051640.62167273
110Insulin resistance_Homo sapiens_hsa049310.62088479
111Systemic lupus erythematosus_Homo sapiens_hsa053220.62026852
112HTLV-I infection_Homo sapiens_hsa051660.60245062
113Estrogen signaling pathway_Homo sapiens_hsa049150.60150967
114AMPK signaling pathway_Homo sapiens_hsa041520.57786550
115Complement and coagulation cascades_Homo sapiens_hsa046100.57573249
116Epstein-Barr virus infection_Homo sapiens_hsa051690.56769729
117Endometrial cancer_Homo sapiens_hsa052130.56322260
118beta-Alanine metabolism_Homo sapiens_hsa004100.55713726
119Non-small cell lung cancer_Homo sapiens_hsa052230.54691406
120Proteoglycans in cancer_Homo sapiens_hsa052050.54414219
121Homologous recombination_Homo sapiens_hsa034400.54078714
122Pentose phosphate pathway_Homo sapiens_hsa000300.53836813
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.52515597
124Arginine biosynthesis_Homo sapiens_hsa002200.51486724
125Measles_Homo sapiens_hsa051620.50868354
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50290504
127Vibrio cholerae infection_Homo sapiens_hsa051100.50185505
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50077546
129Leishmaniasis_Homo sapiens_hsa051400.49306063
130Peroxisome_Homo sapiens_hsa041460.49125467
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49015763
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47576000
133Antigen processing and presentation_Homo sapiens_hsa046120.46910099
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46501202
135Basal cell carcinoma_Homo sapiens_hsa052170.44595383
136TGF-beta signaling pathway_Homo sapiens_hsa043500.44047120
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41712342
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38386234
139Focal adhesion_Homo sapiens_hsa045100.37878932
140Purine metabolism_Homo sapiens_hsa002300.37451717
141Insulin signaling pathway_Homo sapiens_hsa049100.37060216
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35796517
143Shigellosis_Homo sapiens_hsa051310.30747815

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