MED19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)5.61913375
2mitochondrial respiratory chain complex I assembly (GO:0032981)4.96864049
3NADH dehydrogenase complex assembly (GO:0010257)4.96864049
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.96864049
5protein complex biogenesis (GO:0070271)4.87677784
6behavioral response to nicotine (GO:0035095)4.55217812
7ribosomal small subunit assembly (GO:0000028)4.45120261
8mitochondrial respiratory chain complex assembly (GO:0033108)4.43246925
9ribosomal large subunit biogenesis (GO:0042273)4.38291602
10spliceosomal snRNP assembly (GO:0000387)4.30774280
11viral transcription (GO:0019083)4.26898187
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.25346043
13translational termination (GO:0006415)4.20726334
14negative regulation of telomerase activity (GO:0051974)4.20044075
15maturation of SSU-rRNA (GO:0030490)4.18421393
16formation of translation preinitiation complex (GO:0001731)4.17336405
17protein polyglutamylation (GO:0018095)4.16154951
18DNA deamination (GO:0045006)4.13247092
19DNA replication initiation (GO:0006270)4.13095817
20kinetochore assembly (GO:0051382)4.12648302
21ribosomal small subunit biogenesis (GO:0042274)4.09753803
22DNA replication checkpoint (GO:0000076)4.08721501
23DNA strand elongation involved in DNA replication (GO:0006271)4.07967015
24ribonucleoprotein complex biogenesis (GO:0022613)4.07637080
25kinetochore organization (GO:0051383)4.01362071
26water-soluble vitamin biosynthetic process (GO:0042364)3.99782028
27cell proliferation in forebrain (GO:0021846)3.98051145
28ribosome biogenesis (GO:0042254)3.90691982
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88918483
30DNA strand elongation (GO:0022616)3.88139330
31translational initiation (GO:0006413)3.84070075
32mitotic metaphase plate congression (GO:0007080)3.82249097
33translational elongation (GO:0006414)3.77081717
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.72584858
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.72584858
36base-excision repair, AP site formation (GO:0006285)3.72329444
37nucleobase biosynthetic process (GO:0046112)3.69761019
38DNA unwinding involved in DNA replication (GO:0006268)3.69004000
39ATP synthesis coupled proton transport (GO:0015986)3.68773747
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68773747
41telomere maintenance via semi-conservative replication (GO:0032201)3.68444769
42chromatin remodeling at centromere (GO:0031055)3.67394313
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66326119
44viral mRNA export from host cell nucleus (GO:0046784)3.63752553
45CENP-A containing nucleosome assembly (GO:0034080)3.62097386
46negative regulation of transcription regulatory region DNA binding (GO:2000678)3.61716759
47rRNA processing (GO:0006364)3.61242715
48regulation of telomerase activity (GO:0051972)3.60809585
49response to pheromone (GO:0019236)3.58097052
50regulation of telomere maintenance via telomerase (GO:0032210)3.57619148
51chaperone-mediated protein transport (GO:0072321)3.57364047
52spliceosomal complex assembly (GO:0000245)3.56461902
53DNA replication-dependent nucleosome organization (GO:0034723)3.55649517
54DNA replication-dependent nucleosome assembly (GO:0006335)3.55649517
55purine nucleobase biosynthetic process (GO:0009113)3.54184104
56platelet dense granule organization (GO:0060155)3.52839981
57maturation of 5.8S rRNA (GO:0000460)3.50431020
58piRNA metabolic process (GO:0034587)3.50334047
59rRNA metabolic process (GO:0016072)3.50245831
60rRNA modification (GO:0000154)3.47782950
61cellular protein complex disassembly (GO:0043624)3.44071251
62electron transport chain (GO:0022900)3.43959499
63respiratory electron transport chain (GO:0022904)3.43554283
64RNA capping (GO:0036260)3.40212039
657-methylguanosine RNA capping (GO:0009452)3.40212039
66telomere maintenance via recombination (GO:0000722)3.38697408
67proteasome assembly (GO:0043248)3.38609162
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37273967
69viral life cycle (GO:0019058)3.36401890
70DNA replication-independent nucleosome assembly (GO:0006336)3.33872908
71DNA replication-independent nucleosome organization (GO:0034724)3.33872908
72metaphase plate congression (GO:0051310)3.33867510
737-methylguanosine mRNA capping (GO:0006370)3.33525802
74cotranslational protein targeting to membrane (GO:0006613)3.30957079
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.29005165
76termination of RNA polymerase III transcription (GO:0006386)3.29005165
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.28481376
78protein targeting to ER (GO:0045047)3.27711841
79negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.27276131
80mitotic recombination (GO:0006312)3.27021712
81protein localization to kinetochore (GO:0034501)3.26326590
82ribosome assembly (GO:0042255)3.26111213
83pseudouridine synthesis (GO:0001522)3.23755974
84regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21579461
85protein neddylation (GO:0045116)3.21273578
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.20820242
87histone exchange (GO:0043486)3.19841998
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17221355
89mitotic nuclear envelope disassembly (GO:0007077)3.16481282
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16106349
91protein complex disassembly (GO:0043241)3.15981611
92respiratory chain complex IV assembly (GO:0008535)3.14669919
93nuclear pore organization (GO:0006999)3.14024873
94cellular component biogenesis (GO:0044085)3.11743845
95termination of RNA polymerase II transcription (GO:0006369)3.11326243
96telomere maintenance via telomere lengthening (GO:0010833)3.11184430
97sequestering of actin monomers (GO:0042989)3.10566693
98protein localization to endoplasmic reticulum (GO:0070972)3.10547538
99mannosylation (GO:0097502)3.10516174
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10443983
101translation (GO:0006412)3.09645471
102regulation of telomere maintenance (GO:0032204)3.08050759
103establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07697734
104mitotic sister chromatid segregation (GO:0000070)3.07319600
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06596627
106DNA damage response, detection of DNA damage (GO:0042769)3.06333248
107establishment of chromosome localization (GO:0051303)3.05265564
108IMP biosynthetic process (GO:0006188)3.05153859
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05007326
110regulation of cilium movement (GO:0003352)3.04981872
111negative regulation of chromosome segregation (GO:0051985)3.04782320
112macromolecular complex disassembly (GO:0032984)3.03862998
113transcription-coupled nucleotide-excision repair (GO:0006283)3.03774093
114cullin deneddylation (GO:0010388)3.03208147
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03088112
116preassembly of GPI anchor in ER membrane (GO:0016254)3.02954434
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.01160168
118negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01160168
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01160168
120negative regulation of sister chromatid segregation (GO:0033046)3.01160168
121RNA splicing, via transesterification reactions (GO:0000375)3.00199573
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.99708848
123attachment of spindle microtubules to kinetochore (GO:0008608)2.99689374
124protein deneddylation (GO:0000338)2.98399071
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98167485
126peptidyl-arginine omega-N-methylation (GO:0035247)2.97719626
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97420570
128mRNA splicing, via spliceosome (GO:0000398)2.97420570
129establishment of integrated proviral latency (GO:0075713)2.97234238
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.97010653
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97010653
132DNA-templated transcription, termination (GO:0006353)2.96715330
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96143861
134mitotic spindle assembly checkpoint (GO:0007094)2.94999343
135DNA double-strand break processing (GO:0000729)2.94133545
136spindle assembly checkpoint (GO:0071173)2.94078076
137nuclear envelope disassembly (GO:0051081)2.93265874
138regulation of helicase activity (GO:0051095)2.93068769
139male meiosis I (GO:0007141)2.90531217
140cytochrome complex assembly (GO:0017004)2.89844601
141exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89525829
142protein-cofactor linkage (GO:0018065)2.88156074
143somite development (GO:0061053)2.86612300
144GPI anchor metabolic process (GO:0006505)2.86221274
145positive regulation of prostaglandin secretion (GO:0032308)2.84503007
146epithelial cilium movement (GO:0003351)2.77903102
147detection of light stimulus involved in sensory perception (GO:0050962)2.74035682
148detection of light stimulus involved in visual perception (GO:0050908)2.74035682
149positive regulation of mitochondrial fission (GO:0090141)2.72633736
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70654532
151transmission of nerve impulse (GO:0019226)2.68854340
152axoneme assembly (GO:0035082)2.67906931
153nonmotile primary cilium assembly (GO:0035058)2.67532471
154DNA methylation involved in gamete generation (GO:0043046)2.64348639
155tRNA processing (GO:0008033)2.64172751
156negative regulation of response to food (GO:0032096)2.61980055
157negative regulation of appetite (GO:0032099)2.61980055
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61300374
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.60686557
160substrate-independent telencephalic tangential migration (GO:0021826)2.60686557
161negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59427928
162sulfation (GO:0051923)2.58787815
163negative regulation of mast cell activation (GO:0033004)2.57785745
164protein targeting to mitochondrion (GO:0006626)2.56662939
165hydrogen ion transmembrane transport (GO:1902600)2.54213748
166DNA damage induced protein phosphorylation (GO:0006975)2.53567533
167positive regulation of fatty acid transport (GO:2000193)2.53281504
168proton transport (GO:0015992)2.52842442
169negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.51031252
170establishment of protein localization to mitochondrion (GO:0072655)2.51009495
171purine deoxyribonucleotide catabolic process (GO:0009155)2.50239760
172metallo-sulfur cluster assembly (GO:0031163)2.48416043
173iron-sulfur cluster assembly (GO:0016226)2.48416043
174deoxyribonucleotide catabolic process (GO:0009264)2.47217875
175hydrogen transport (GO:0006818)2.46010952
176endoderm formation (GO:0001706)2.45199723
177negative regulation of DNA biosynthetic process (GO:2000279)2.43082904
178positive regulation of oligodendrocyte differentiation (GO:0048714)2.41970500
179L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41481304
180negative regulation of DNA-templated transcription, elongation (GO:0032785)2.41435426
181protein localization to mitochondrion (GO:0070585)2.40408444
182GTP biosynthetic process (GO:0006183)2.38942074
183regulation of microtubule-based movement (GO:0060632)2.38846815
184indolalkylamine metabolic process (GO:0006586)2.38156334
185meiosis I (GO:0007127)2.38038833
186regulation of transcription regulatory region DNA binding (GO:2000677)2.37655850
187ubiquinone biosynthetic process (GO:0006744)2.37214861
188cornea development in camera-type eye (GO:0061303)2.36158158
189regulation of action potential (GO:0098900)2.36048529
190transcription from RNA polymerase III promoter (GO:0006383)2.35593092
191pyrimidine nucleobase catabolic process (GO:0006208)2.34462944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13248407
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.79635329
3EZH2_22144423_ChIP-Seq_EOC_Human4.05867985
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.64828677
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59274309
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51917980
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36327863
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26059469
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.20248339
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18161330
11ZNF274_21170338_ChIP-Seq_K562_Hela3.18147069
12MYC_19030024_ChIP-ChIP_MESCs_Mouse3.13121523
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07161631
14* ETS1_20019798_ChIP-Seq_JURKAT_Human3.06559486
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04593709
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.95814345
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84883350
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74705424
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73255207
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72849386
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60534741
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57188853
23XRN2_22483619_ChIP-Seq_HELA_Human2.52291570
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47754547
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47326193
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45184623
27VDR_23849224_ChIP-Seq_CD4+_Human2.28045540
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21159439
29VDR_22108803_ChIP-Seq_LS180_Human2.20796171
30GBX2_23144817_ChIP-Seq_PC3_Human2.16740015
31TTF2_22483619_ChIP-Seq_HELA_Human2.14853932
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14717330
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10220481
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07619144
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06905799
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05165227
37DCP1A_22483619_ChIP-Seq_HELA_Human2.04496994
38BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03850602
39NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01351692
40IRF1_19129219_ChIP-ChIP_H3396_Human1.97022169
41FOXP3_21729870_ChIP-Seq_TREG_Human1.96173721
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93943303
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.93803471
44GABP_19822575_ChIP-Seq_HepG2_Human1.93728292
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92971473
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91609803
47IGF1R_20145208_ChIP-Seq_DFB_Human1.88887469
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83678282
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80910123
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.80047922
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79978151
52TP53_22573176_ChIP-Seq_HFKS_Human1.76161868
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75614593
54AR_21909140_ChIP-Seq_LNCAP_Human1.74623784
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.73980382
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72010871
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69832735
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68535465
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66373493
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66035014
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63488347
62ELK1_19687146_ChIP-ChIP_HELA_Human1.62359786
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59600719
64CIITA_25753668_ChIP-Seq_RAJI_Human1.57039880
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56377731
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.54789957
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.54789957
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.54789957
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.54185301
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53547682
71RNF2_27304074_Chip-Seq_NSC_Mouse1.51848629
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47245420
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46746148
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46093432
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44672114
76FUS_26573619_Chip-Seq_HEK293_Human1.44500329
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43316537
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42948398
79EWS_26573619_Chip-Seq_HEK293_Human1.42802867
80KDM5A_27292631_Chip-Seq_BREAST_Human1.40357311
81REST_21632747_ChIP-Seq_MESCs_Mouse1.39843770
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39720886
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.38577530
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.37029494
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36379000
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.34966169
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34811897
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34487867
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34180824
90* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33394097
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.33344802
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31068372
93P300_19829295_ChIP-Seq_ESCs_Human1.30364462
94NCOR_22424771_ChIP-Seq_293T_Human1.29385123
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28716475
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28231878
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28197709
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27593578
99* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26197575
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25841614
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24649350
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23875727
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23094634
104* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20391172
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18252099
106TAF15_26573619_Chip-Seq_HEK293_Human1.17429389
107MYC_18940864_ChIP-ChIP_HL60_Human1.15235256
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15049139
109AR_20517297_ChIP-Seq_VCAP_Human1.14304098
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13917504
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.12682184
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.11285540
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11285540
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11063391
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.10064227
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09096072
117CBP_20019798_ChIP-Seq_JUKART_Human1.09096072
118SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08183942
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07308719
120ERA_21632823_ChIP-Seq_H3396_Human1.07098399
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06271421
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.06250802
123* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05839510
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05585906
125ER_23166858_ChIP-Seq_MCF-7_Human1.04079304
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03436323
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02848004
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02709220
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02199686
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.01327932
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00671097
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00488677
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99406690
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99099608
135HTT_18923047_ChIP-ChIP_STHdh_Human0.99058594
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99054836
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98793201
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98356831
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98329946
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98146884
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97786547
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.97481878
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96811849
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96750645
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96534376
146NANOG_20526341_ChIP-Seq_ESCs_Human0.96307184
147* ELK1_22589737_ChIP-Seq_MCF10A_Human0.96048978
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95884899
149SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95596041
150NANOG_19829295_ChIP-Seq_ESCs_Human0.93384587
151SOX2_19829295_ChIP-Seq_ESCs_Human0.93384587
152* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92219038
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91278572
154TAF2_19829295_ChIP-Seq_ESCs_Human0.91060336
155TFEB_21752829_ChIP-Seq_HELA_Human0.91051742
156P53_21459846_ChIP-Seq_SAOS-2_Human0.90015984
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89533639
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89199502
159NOTCH1_21737748_ChIP-Seq_TLL_Human0.88875885
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.88730044
161NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88231657
162HOXB7_26014856_ChIP-Seq_BT474_Human0.87768864
163JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87697184
164* MYC_19829295_ChIP-Seq_ESCs_Human0.87691866
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87594134
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.87438246
167FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87285699
168PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87270858
169SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87226186
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86652232
171PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84212058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67341683
2MP0003111_abnormal_nucleus_morphology4.26835670
3MP0010094_abnormal_chromosome_stability4.25278527
4MP0004957_abnormal_blastocyst_morpholog4.19781646
5MP0003077_abnormal_cell_cycle3.42584317
6MP0008058_abnormal_DNA_repair3.26044407
7MP0008057_abnormal_DNA_replication3.10948274
8MP0008877_abnormal_DNA_methylation2.83640814
9MP0008932_abnormal_embryonic_tissue2.81888874
10MP0005646_abnormal_pituitary_gland2.76659984
11MP0010030_abnormal_orbit_morphology2.61907294
12MP0003123_paternal_imprinting2.60747464
13MP0009379_abnormal_foot_pigmentation2.36754217
14MP0003315_abnormal_perineum_morphology2.34993871
15MP0006276_abnormal_autonomic_nervous2.29552099
16MP0008007_abnormal_cellular_replicative2.29430439
17MP0003786_premature_aging2.26663776
18MP0002653_abnormal_ependyma_morphology2.18986671
19MP0002837_dystrophic_cardiac_calcinosis2.16132351
20MP0001730_embryonic_growth_arrest2.10870064
21MP0000350_abnormal_cell_proliferation2.04339868
22MP0005551_abnormal_eye_electrophysiolog1.97984510
23MP0003718_maternal_effect1.97695236
24MP0001968_abnormal_touch/_nociception1.92129418
25MP0005379_endocrine/exocrine_gland_phen1.91521868
26MP0000631_abnormal_neuroendocrine_gland1.89992074
27MP0003646_muscle_fatigue1.87241528
28MP0006292_abnormal_olfactory_placode1.86428833
29MP0002876_abnormal_thyroid_physiology1.81349332
30MP0004142_abnormal_muscle_tone1.81049057
31MP0002160_abnormal_reproductive_system1.76064913
32MP0003195_calcinosis1.75918986
33MP0005645_abnormal_hypothalamus_physiol1.72897954
34MP0003011_delayed_dark_adaptation1.69591224
35MP0003941_abnormal_skin_development1.69367048
36MP0008789_abnormal_olfactory_epithelium1.67539660
37MP0004145_abnormal_muscle_electrophysio1.67345956
38MP0002736_abnormal_nociception_after1.67212903
39MP0009745_abnormal_behavioral_response1.67146793
40MP0002272_abnormal_nervous_system1.64167229
41MP0001697_abnormal_embryo_size1.62538693
42MP0004133_heterotaxia1.62209405
43MP0002210_abnormal_sex_determination1.58782733
44MP0004885_abnormal_endolymph1.57097003
45MP0002085_abnormal_embryonic_tissue1.49231000
46MP0005380_embryogenesis_phenotype1.49043497
47MP0001672_abnormal_embryogenesis/_devel1.49043497
48MP0004270_analgesia1.48402061
49MP0008872_abnormal_physiological_respon1.43556617
50MP0001145_abnormal_male_reproductive1.42439368
51MP0003121_genomic_imprinting1.42327245
52MP0002080_prenatal_lethality1.39084582
53MP0009046_muscle_twitch1.38993241
54MP0005389_reproductive_system_phenotype1.38688735
55MP0003136_yellow_coat_color1.38236622
56MP0003890_abnormal_embryonic-extraembry1.38180398
57MP0008875_abnormal_xenobiotic_pharmacok1.37833553
58MP0002084_abnormal_developmental_patter1.37550861
59MP0002638_abnormal_pupillary_reflex1.36476673
60MP0002277_abnormal_respiratory_mucosa1.36475639
61MP0001984_abnormal_olfaction1.36402323
62MP0003119_abnormal_digestive_system1.34796604
63MP0001905_abnormal_dopamine_level1.34554922
64MP0001293_anophthalmia1.34305768
65MP0000313_abnormal_cell_death1.34174411
66MP0005253_abnormal_eye_physiology1.33875709
67MP0001188_hyperpigmentation1.31975510
68MP0000778_abnormal_nervous_system1.29186723
69MP0005394_taste/olfaction_phenotype1.27047057
70MP0005499_abnormal_olfactory_system1.27047057
71MP0002572_abnormal_emotion/affect_behav1.26983794
72MP0003984_embryonic_growth_retardation1.26195944
73MP0002751_abnormal_autonomic_nervous1.25837104
74MP0000372_irregular_coat_pigmentation1.25078184
75MP0002557_abnormal_social/conspecific_i1.24321384
76MP0001929_abnormal_gametogenesis1.24102932
77MP0000490_abnormal_crypts_of1.23987333
78MP0002088_abnormal_embryonic_growth/wei1.23834913
79MP0005423_abnormal_somatic_nervous1.23032486
80MP0000653_abnormal_sex_gland1.21664785
81MP0003567_abnormal_fetal_cardiomyocyte1.21462158
82MP0000566_synostosis1.21326485
83MP0010352_gastrointestinal_tract_polyps1.18530108
84MP0004197_abnormal_fetal_growth/weight/1.15332292
85MP0002734_abnormal_mechanical_nocicepti1.14071697
86MP0003635_abnormal_synaptic_transmissio1.13063666
87MP0001919_abnormal_reproductive_system1.11318946
88MP0005195_abnormal_posterior_eye1.10212402
89MP0008775_abnormal_heart_ventricle1.08883908
90MP0000647_abnormal_sebaceous_gland1.07646347
91MP0002733_abnormal_thermal_nociception1.07096040
92MP0001970_abnormal_pain_threshold1.06053717
93MP0002064_seizures1.05919980
94MP0000049_abnormal_middle_ear1.05367265
95MP0002102_abnormal_ear_morphology1.05347146
96MP0003122_maternal_imprinting1.05332376
97MP0002086_abnormal_extraembryonic_tissu1.05135918
98MP0004147_increased_porphyrin_level1.04609684
99MP0000427_abnormal_hair_cycle1.04142297
100MP0001529_abnormal_vocalization1.02893018
101MP0002063_abnormal_learning/memory/cond1.02771675
102MP0002234_abnormal_pharynx_morphology1.02101867
103MP0002019_abnormal_tumor_incidence1.01894388
104MP0002735_abnormal_chemical_nociception1.01175675
105MP0002095_abnormal_skin_pigmentation1.01104649
106MP0001486_abnormal_startle_reflex1.00513409
107MP0005084_abnormal_gallbladder_morpholo1.00035681
108MP0002184_abnormal_innervation0.99909277
109MP0002752_abnormal_somatic_nervous0.99792215
110MP0002163_abnormal_gland_morphology0.97520343
111MP0010307_abnormal_tumor_latency0.97339951
112MP0001963_abnormal_hearing_physiology0.96765922
113MP0000026_abnormal_inner_ear0.96419090
114MP0003861_abnormal_nervous_system0.96067678
115MP0003879_abnormal_hair_cell0.93387968
116MP0003937_abnormal_limbs/digits/tail_de0.93184463
117MP0002132_abnormal_respiratory_system0.92113606
118MP0003186_abnormal_redox_activity0.91303100
119MP0006072_abnormal_retinal_apoptosis0.91196768
120MP0003698_abnormal_male_reproductive0.90391666
121MP0001119_abnormal_female_reproductive0.90380424
122MP0003938_abnormal_ear_development0.89768433
123MP0004924_abnormal_behavior0.89166820
124MP0005386_behavior/neurological_phenoty0.89166820
125MP0001286_abnormal_eye_development0.88138328
126MP0001764_abnormal_homeostasis0.87098760
127MP0006036_abnormal_mitochondrial_physio0.86155056
128MP0009250_abnormal_appendicular_skeleto0.85568804
129MP0009053_abnormal_anal_canal0.84817484
130MP0002282_abnormal_trachea_morphology0.84525246
131MP0004808_abnormal_hematopoietic_stem0.84323806
132MP0002822_catalepsy0.82741516
133MP0000537_abnormal_urethra_morphology0.81413509
134MP0001502_abnormal_circadian_rhythm0.80181735
135MP0002396_abnormal_hematopoietic_system0.79681743
136MP0002233_abnormal_nose_morphology0.78684555
137MP0000358_abnormal_cell_content/0.78631579
138MP0005671_abnormal_response_to0.78128194
139MP0003787_abnormal_imprinting0.77995507
140MP0008995_early_reproductive_senescence0.77880977
141MP0004742_abnormal_vestibular_system0.77334525
142MP0002111_abnormal_tail_morphology0.77289837
143MP0002938_white_spotting0.75176175
144MP0001849_ear_inflammation0.75126505
145MP0001485_abnormal_pinna_reflex0.74433515
146MP0002161_abnormal_fertility/fecundity0.74309943
147MP0003755_abnormal_palate_morphology0.71869562
148MP0003880_abnormal_central_pattern0.71771525
149MP0003936_abnormal_reproductive_system0.70413485
150MP0002114_abnormal_axial_skeleton0.68958006
151MP0001986_abnormal_taste_sensitivity0.67982423
152MP0000432_abnormal_head_morphology0.65360480
153MP0001545_abnormal_hematopoietic_system0.64090824
154MP0005397_hematopoietic_system_phenotyp0.64090824
155MP0009703_decreased_birth_body0.63300918
156MP0009672_abnormal_birth_weight0.62221337
157MP0003878_abnormal_ear_physiology0.61298698
158MP0005377_hearing/vestibular/ear_phenot0.61298698
159MP0002081_perinatal_lethality0.61232651
160MP0002249_abnormal_larynx_morphology0.59869170
161MP0005075_abnormal_melanosome_morpholog0.58917639
162MP0000703_abnormal_thymus_morphology0.58229975
163MP0005384_cellular_phenotype0.57928369

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.63499109
2Abnormality of cells of the erythroid lineage (HP:0012130)4.51882378
3Breast hypoplasia (HP:0003187)4.32982244
4Abnormal number of erythroid precursors (HP:0012131)4.28124065
5Mitochondrial inheritance (HP:0001427)3.78412328
6Acute necrotizing encephalopathy (HP:0006965)3.68243266
7Reticulocytopenia (HP:0001896)3.66051704
8Increased CSF lactate (HP:0002490)3.56676457
9Carpal bone hypoplasia (HP:0001498)3.52117903
10Patellar aplasia (HP:0006443)3.51837931
11Hepatocellular necrosis (HP:0001404)3.48648243
12Abnormal mitochondria in muscle tissue (HP:0008316)3.42350786
13Abnormality of midbrain morphology (HP:0002418)3.42076596
14Molar tooth sign on MRI (HP:0002419)3.42076596
15Aplasia/Hypoplasia of the patella (HP:0006498)3.33337626
16Supernumerary spleens (HP:0009799)3.18325749
17Congenital stationary night blindness (HP:0007642)3.17516441
18Pancreatic cysts (HP:0001737)3.15897395
19Progressive macrocephaly (HP:0004481)3.10768888
20Acute encephalopathy (HP:0006846)3.10082545
213-Methylglutaconic aciduria (HP:0003535)3.06984618
22Pancreatic fibrosis (HP:0100732)3.06826034
23Hepatic necrosis (HP:0002605)3.05790470
24Cerebral hypomyelination (HP:0006808)3.04402878
25Nephronophthisis (HP:0000090)3.02752894
26Absent thumb (HP:0009777)2.99947330
27Colon cancer (HP:0003003)2.99767619
28Macrocytic anemia (HP:0001972)2.98769504
29Abnormality of the labia minora (HP:0012880)2.96055777
30True hermaphroditism (HP:0010459)2.95472611
31Medulloblastoma (HP:0002885)2.95236689
32Pendular nystagmus (HP:0012043)2.94448224
33Oral leukoplakia (HP:0002745)2.84825282
34Increased hepatocellular lipid droplets (HP:0006565)2.80330938
35Absent radius (HP:0003974)2.78108119
36Rough bone trabeculation (HP:0100670)2.77551374
37Pallor (HP:0000980)2.70667802
38Meckel diverticulum (HP:0002245)2.68235361
39Methylmalonic acidemia (HP:0002912)2.66123866
40Lipid accumulation in hepatocytes (HP:0006561)2.63402028
41Medial flaring of the eyebrow (HP:0010747)2.62929712
42Abnormality of the anterior horn cell (HP:0006802)2.61701324
43Degeneration of anterior horn cells (HP:0002398)2.61701324
44Aplasia involving forearm bones (HP:0009822)2.61222121
45Absent forearm bone (HP:0003953)2.61222121
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60494832
47Abnormal rod and cone electroretinograms (HP:0008323)2.59269937
48Abnormality of the ileum (HP:0001549)2.58564455
49Renal Fanconi syndrome (HP:0001994)2.58199021
50Methylmalonic aciduria (HP:0012120)2.57773559
51Chromsome breakage (HP:0040012)2.57132104
52Abolished electroretinogram (ERG) (HP:0000550)2.56410570
53Horseshoe kidney (HP:0000085)2.55826545
54Rhabdomyosarcoma (HP:0002859)2.48218277
55Abnormality of the preputium (HP:0100587)2.44999763
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44239868
57Ependymoma (HP:0002888)2.43751336
58Abnormality of the renal medulla (HP:0100957)2.43012567
59Esophageal atresia (HP:0002032)2.42298087
60Aplastic anemia (HP:0001915)2.41560059
61Selective tooth agenesis (HP:0001592)2.38346339
62Type II lissencephaly (HP:0007260)2.36606155
63Hyperglycinemia (HP:0002154)2.36350999
64Secondary amenorrhea (HP:0000869)2.36008752
65Short tibia (HP:0005736)2.35475052
66Abnormality of chromosome stability (HP:0003220)2.34890935
67Abnormal lung lobation (HP:0002101)2.34182910
68Tongue fasciculations (HP:0001308)2.33545124
69Optic disc pallor (HP:0000543)2.33267791
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.32954419
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31992276
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30996549
73Hypoplasia of the radius (HP:0002984)2.30404232
74Triphalangeal thumb (HP:0001199)2.30018842
75Gait imbalance (HP:0002141)2.29040428
76Abnormal number of incisors (HP:0011064)2.28991126
77Impulsivity (HP:0100710)2.27761531
78Humeroradial synostosis (HP:0003041)2.27126189
79Synostosis involving the elbow (HP:0003938)2.27126189
80Sclerocornea (HP:0000647)2.24204750
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.23498219
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.23241762
83Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.22901164
84Short 1st metacarpal (HP:0010034)2.22901164
85Cerebral edema (HP:0002181)2.21852502
86Cleft eyelid (HP:0000625)2.21452816
87Abnormality of the proximal phalanges of the hand (HP:0009834)2.21018329
88Severe visual impairment (HP:0001141)2.20640942
89Abnormality of cochlea (HP:0000375)2.19757539
90Premature ovarian failure (HP:0008209)2.19540469
91Stenosis of the external auditory canal (HP:0000402)2.19403868
92Congenital primary aphakia (HP:0007707)2.18930990
93Neoplasm of the pancreas (HP:0002894)2.16245458
94Chronic hepatic failure (HP:0100626)2.15923759
95Lactic acidosis (HP:0003128)2.14931070
96Premature graying of hair (HP:0002216)2.14846749
97Small intestinal stenosis (HP:0012848)2.14648160
98Duodenal stenosis (HP:0100867)2.14648160
99Increased intramyocellular lipid droplets (HP:0012240)2.14594136
100Trismus (HP:0000211)2.14396352
101Renal cortical cysts (HP:0000803)2.13725631
102Abnormality of the renal cortex (HP:0011035)2.13177551
103Attenuation of retinal blood vessels (HP:0007843)2.10718603
104Nephrogenic diabetes insipidus (HP:0009806)2.09380060
105Agnosia (HP:0010524)2.08817922
106CNS hypomyelination (HP:0003429)2.08763769
107Aplasia/hypoplasia of the uterus (HP:0008684)2.08026081
108Gastrointestinal atresia (HP:0002589)2.07382330
109Microretrognathia (HP:0000308)2.06718959
110Abnormal trabecular bone morphology (HP:0100671)2.04637202
111Atrophy/Degeneration involving motor neurons (HP:0007373)2.04271799
112Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03641976
113Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01268452
114Facial cleft (HP:0002006)1.99758820
115IgG deficiency (HP:0004315)1.99281976
116Hypoplasia of the uterus (HP:0000013)1.99250963
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98944907
118Retinal dysplasia (HP:0007973)1.98707894
119Glossoptosis (HP:0000162)1.97824520
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97224308
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97224308
122Atresia of the external auditory canal (HP:0000413)1.96939667
123Facial hemangioma (HP:0000329)1.96286752
124Decreased central vision (HP:0007663)1.96235498
125Increased corneal curvature (HP:0100692)1.95856429
126Keratoconus (HP:0000563)1.95856429
127Abnormality of the 1st metacarpal (HP:0010009)1.95238841
128Tracheoesophageal fistula (HP:0002575)1.94341679
129Rectal fistula (HP:0100590)1.89498251
130Rectovaginal fistula (HP:0000143)1.89498251
131Abnormality of the phalanges of the 5th finger (HP:0004213)1.89343217
132Respiratory failure (HP:0002878)1.88779888
133Adrenal hypoplasia (HP:0000835)1.88675473
134Muscle fibrillation (HP:0010546)1.88261554
135Irregular epiphyses (HP:0010582)1.88212896
136Shawl scrotum (HP:0000049)1.88016433
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.86841988
138Nephroblastoma (Wilms tumor) (HP:0002667)1.86608059
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86365645
140Abnormality of abdominal situs (HP:0011620)1.86180851
141Abdominal situs inversus (HP:0003363)1.86180851
142Abnormality of alanine metabolism (HP:0010916)1.85735603
143Hyperalaninemia (HP:0003348)1.85735603
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85735603
145Asplenia (HP:0001746)1.84657601
146Bony spicule pigmentary retinopathy (HP:0007737)1.84536774
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.84514707
148Exertional dyspnea (HP:0002875)1.84068896
149Male pseudohermaphroditism (HP:0000037)1.83926002
150Anencephaly (HP:0002323)1.83640761
151Myelodysplasia (HP:0002863)1.82950848
152Inability to walk (HP:0002540)1.81687818
153Increased serum lactate (HP:0002151)1.80541572
154Abnormality of the middle phalanges of the toes (HP:0010183)1.79949808
155Lissencephaly (HP:0001339)1.79720902
156Oligodactyly (hands) (HP:0001180)1.78689497
157Genital tract atresia (HP:0001827)1.78435399
158Abnormal hemoglobin (HP:0011902)1.78383128
159Abnormality of renal resorption (HP:0011038)1.78062515
160Supernumerary bones of the axial skeleton (HP:0009144)1.77761154
161Sparse eyelashes (HP:0000653)1.77487676
162Breast aplasia (HP:0100783)1.77354722
163Sloping forehead (HP:0000340)1.77102420
164Abnormality of the duodenum (HP:0002246)1.76601033
165Concave nail (HP:0001598)1.76500880
166Progressive muscle weakness (HP:0003323)1.76066056
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.75737256
168Vaginal atresia (HP:0000148)1.75684788
169Type I transferrin isoform profile (HP:0003642)1.75433243
17011 pairs of ribs (HP:0000878)1.75114204
171CNS demyelination (HP:0007305)1.74936861
172Rib fusion (HP:0000902)1.74255534
173Abnormality of the septum pellucidum (HP:0007375)1.74244980
174Aplasia/hypoplasia of the humerus (HP:0006507)1.73447822
175Thyroiditis (HP:0100646)1.72972005
176Abnormality of urine glucose concentration (HP:0011016)1.72951781
177Glycosuria (HP:0003076)1.72951781
178Agitation (HP:0000713)1.72897279
179Ectopic kidney (HP:0000086)1.72433468
180Overlapping toe (HP:0001845)1.72376614
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.72276362
182Polyphagia (HP:0002591)1.72150460
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72085786
184Myokymia (HP:0002411)1.72009694
185Embryonal renal neoplasm (HP:0011794)1.69718249
186Short thumb (HP:0009778)1.69483929
187Glioma (HP:0009733)1.69257295
188Neoplasm of striated muscle (HP:0009728)1.67992786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.84936499
2WEE14.48292612
3MAP4K24.02900389
4EIF2AK13.82481846
5SRPK13.78745941
6BCKDK3.09174773
7CDC72.86123661
8MKNK12.78939046
9TLK12.67955718
10MKNK22.66898006
11MAP2K62.56781249
12FRK2.52214184
13STK162.30596390
14TSSK62.29984482
15ADRBK22.28993966
16GRK12.22383118
17PLK12.21785515
18SCYL22.17793130
19VRK12.01548934
20TTK2.01220902
21NME21.97539316
22PNCK1.93914166
23PLK31.91110505
24PLK41.90656033
25WNK31.89584841
26BRSK11.85080485
27BRSK21.84930787
28EPHA21.76188827
29MAP3K41.73519608
30NUAK11.72547733
31NEK21.72271878
32DYRK31.71162396
33TAOK31.70694488
34ACVR1B1.60751698
35AURKA1.60126985
36VRK21.57984615
37NEK11.57669026
38CDK71.56351916
39RPS6KB21.53052903
40CSNK1G21.48362811
41PINK11.48195312
42MAP3K51.42800215
43CHEK21.40842330
44MAPK131.39958687
45AURKB1.39797298
46ATR1.33914570
47DYRK21.33326918
48TRIM281.32323852
49BMPR1B1.30994542
50WNK41.25892994
51TXK1.25678783
52KDR1.23529051
53PIM21.22301873
54CSNK1A1L1.17531009
55TESK21.16697695
56EIF2AK31.16556176
57SIK21.15618038
58CDK121.13812172
59BRAF1.09030351
60INSRR1.08233751
61LATS21.07951736
62NME11.05710424
63CHEK11.01079765
64PRKCG0.93942000
65MELK0.91231720
66MUSK0.90999299
67PRKCI0.89722411
68OXSR10.89430690
69ERBB30.89214823
70PBK0.88262266
71EIF2AK20.86881169
72CCNB10.86503689
73BCR0.85266927
74GRK70.84039635
75AKT30.82193917
76TIE10.82176093
77MAP3K80.81669722
78CDK20.81390456
79ATM0.81301455
80ALK0.79425446
81RPS6KA40.77134476
82CDK40.76840753
83ZAK0.76353808
84PHKG20.75840901
85PHKG10.75840901
86PAK30.75571900
87CSNK2A10.75452829
88ADRBK10.74878191
89CSNK2A20.74814126
90ARAF0.74623445
91CDK80.72478051
92STK390.72263588
93STK38L0.71269954
94GRK50.69058498
95PAK40.68208036
96PRKCE0.66456985
97STK40.66264873
98MAPKAPK30.62737099
99YES10.62213825
100RPS6KA50.60005675
101PAK10.59279863
102TESK10.58591925
103NTRK20.57693186
104CASK0.57405743
105PKN10.57049864
106MST40.56387275
107CDK10.56237340
108CSNK1E0.55458537
109CDK190.54498521
110STK100.53606802
111MAP3K110.53570120
112CSNK1A10.52118065
113PDK20.49403737
114PIM10.48088194
115ABL20.46255585
116PRKACA0.45395325
117LMTK20.43864333
118CAMK2A0.43737515
119PRKCQ0.43038096
120EPHA40.42146616
121PLK20.39565716
122CDK140.39386630
123MARK10.39277868
124PIK3CA0.38392784
125BRD40.36681057
126IKBKB0.35891392
127PRKCA0.35830398
128MAPKAPK50.35427971
129TGFBR10.34823431
130ILK0.34242773
131CSNK1G30.33993436
132FLT30.33654674
133CDK11A0.33330949
134MAP2K70.33187035
135SIK30.32283933
136DAPK20.32121041
137PRKG20.31988233
138CDK180.31949367
139RAF10.30966248
140PRKDC0.30434188
141LIMK10.30275368
142CDK150.29394409
143MINK10.29297536
144PRKCZ0.27722161
145CDK50.27666906
146RPS6KA10.27403179
147MAP3K120.27256305
148MARK30.27119855
149PASK0.26567336
150PAK60.26281593
151DYRK1B0.25797305
152CSNK1D0.25762780
153UHMK10.25177562
154RPS6KB10.25056601
155GRK60.24375511
156TAOK20.23212795
157DAPK10.22136281
158CSNK1G10.21116099
159GSK3B0.21041662

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42902761
2Ribosome_Homo sapiens_hsa030104.41633258
3RNA polymerase_Homo sapiens_hsa030204.03070219
4Spliceosome_Homo sapiens_hsa030403.71420909
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71263429
6Mismatch repair_Homo sapiens_hsa034303.63207578
7RNA transport_Homo sapiens_hsa030133.38793464
8Proteasome_Homo sapiens_hsa030503.38586181
9Base excision repair_Homo sapiens_hsa034102.96325159
10Homologous recombination_Homo sapiens_hsa034402.94822308
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90808717
12Cell cycle_Homo sapiens_hsa041102.61969949
13Pyrimidine metabolism_Homo sapiens_hsa002402.59598427
14Nucleotide excision repair_Homo sapiens_hsa034202.55985349
15Fanconi anemia pathway_Homo sapiens_hsa034602.21171695
16Basal transcription factors_Homo sapiens_hsa030222.16659347
17mRNA surveillance pathway_Homo sapiens_hsa030152.04399621
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01346335
19One carbon pool by folate_Homo sapiens_hsa006701.93454598
20Non-homologous end-joining_Homo sapiens_hsa034501.91776661
21Nicotine addiction_Homo sapiens_hsa050331.90804524
22RNA degradation_Homo sapiens_hsa030181.82454643
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69287603
24Sulfur metabolism_Homo sapiens_hsa009201.68685666
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53734342
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.51360705
27Oocyte meiosis_Homo sapiens_hsa041141.50295726
28Purine metabolism_Homo sapiens_hsa002301.50034313
29p53 signaling pathway_Homo sapiens_hsa041151.44802720
30Primary immunodeficiency_Homo sapiens_hsa053401.35162366
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31758994
32Collecting duct acid secretion_Homo sapiens_hsa049661.31608404
33Huntingtons disease_Homo sapiens_hsa050161.27606082
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23832838
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22678037
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.21480116
37Parkinsons disease_Homo sapiens_hsa050121.19120840
38Epstein-Barr virus infection_Homo sapiens_hsa051691.16344689
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14372914
40Steroid biosynthesis_Homo sapiens_hsa001001.14237940
41Butanoate metabolism_Homo sapiens_hsa006501.11869982
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06169183
43Oxidative phosphorylation_Homo sapiens_hsa001901.04119746
44Fatty acid elongation_Homo sapiens_hsa000621.03023147
45Peroxisome_Homo sapiens_hsa041461.01208606
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99901066
47Systemic lupus erythematosus_Homo sapiens_hsa053220.97505091
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94274573
49Chemical carcinogenesis_Homo sapiens_hsa052040.92931993
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.92639383
51Taste transduction_Homo sapiens_hsa047420.91429276
52Morphine addiction_Homo sapiens_hsa050320.89923691
53Nitrogen metabolism_Homo sapiens_hsa009100.89324764
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88556358
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.86978301
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86185677
57Olfactory transduction_Homo sapiens_hsa047400.85957688
58GABAergic synapse_Homo sapiens_hsa047270.85423909
59Retinol metabolism_Homo sapiens_hsa008300.81298573
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81055923
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77462587
62Caffeine metabolism_Homo sapiens_hsa002320.76842809
63Herpes simplex infection_Homo sapiens_hsa051680.74948135
64Viral carcinogenesis_Homo sapiens_hsa052030.73091088
65Tryptophan metabolism_Homo sapiens_hsa003800.71804458
66Hippo signaling pathway_Homo sapiens_hsa043900.69989211
67Alcoholism_Homo sapiens_hsa050340.69855332
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67260656
69Protein export_Homo sapiens_hsa030600.66548540
70Thyroid cancer_Homo sapiens_hsa052160.66016035
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.63890901
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61579786
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61532358
74Ether lipid metabolism_Homo sapiens_hsa005650.61102468
75Vitamin B6 metabolism_Homo sapiens_hsa007500.59692848
76Hedgehog signaling pathway_Homo sapiens_hsa043400.59553679
77HTLV-I infection_Homo sapiens_hsa051660.58723468
78Cocaine addiction_Homo sapiens_hsa050300.56101282
79Propanoate metabolism_Homo sapiens_hsa006400.56042193
80Basal cell carcinoma_Homo sapiens_hsa052170.55928570
81Folate biosynthesis_Homo sapiens_hsa007900.55472999
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55119568
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54482973
84Sulfur relay system_Homo sapiens_hsa041220.54030780
85Antigen processing and presentation_Homo sapiens_hsa046120.53663105
86Alzheimers disease_Homo sapiens_hsa050100.51703673
87Phototransduction_Homo sapiens_hsa047440.51417591
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.50766158
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50047775
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49743270
91Insulin secretion_Homo sapiens_hsa049110.46505910
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46253385
93Rheumatoid arthritis_Homo sapiens_hsa053230.45264310
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45007524
95TGF-beta signaling pathway_Homo sapiens_hsa043500.43952171
96Circadian entrainment_Homo sapiens_hsa047130.43279741
97Glutathione metabolism_Homo sapiens_hsa004800.42732985
98Biosynthesis of amino acids_Homo sapiens_hsa012300.42404364
99Asthma_Homo sapiens_hsa053100.42208761
100Arachidonic acid metabolism_Homo sapiens_hsa005900.41881121
101Glutamatergic synapse_Homo sapiens_hsa047240.40564551
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39138892
103Wnt signaling pathway_Homo sapiens_hsa043100.38370467
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37702645
105Dopaminergic synapse_Homo sapiens_hsa047280.37412767
106MicroRNAs in cancer_Homo sapiens_hsa052060.34917350
107Colorectal cancer_Homo sapiens_hsa052100.33867130
108Fat digestion and absorption_Homo sapiens_hsa049750.33665694
109Pentose phosphate pathway_Homo sapiens_hsa000300.33492015
110Salivary secretion_Homo sapiens_hsa049700.33434339
111Fructose and mannose metabolism_Homo sapiens_hsa000510.33197958
112Serotonergic synapse_Homo sapiens_hsa047260.32054944
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31360351
114Shigellosis_Homo sapiens_hsa051310.30320191
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30152409
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29268491
117Tight junction_Homo sapiens_hsa045300.28810919
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28390690
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26860164
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25246603
121Pathways in cancer_Homo sapiens_hsa052000.20925794
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.20860847
123Notch signaling pathway_Homo sapiens_hsa043300.20763364
124Bladder cancer_Homo sapiens_hsa052190.20539968
125Metabolic pathways_Homo sapiens_hsa011000.18881818
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17427151
127Cardiac muscle contraction_Homo sapiens_hsa042600.16983701
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16884902
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16842388
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16308459
131Melanoma_Homo sapiens_hsa052180.15673393
132Linoleic acid metabolism_Homo sapiens_hsa005910.14831192
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14416374
134N-Glycan biosynthesis_Homo sapiens_hsa005100.14157044
135Small cell lung cancer_Homo sapiens_hsa052220.12231267
136Apoptosis_Homo sapiens_hsa042100.12145033
137Regulation of autophagy_Homo sapiens_hsa041400.11567285
138Hepatitis B_Homo sapiens_hsa051610.11111317
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.08275888
140HIF-1 signaling pathway_Homo sapiens_hsa040660.08258291
141Acute myeloid leukemia_Homo sapiens_hsa052210.08097105
142Melanogenesis_Homo sapiens_hsa049160.08050166
143Vibrio cholerae infection_Homo sapiens_hsa051100.08029104
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07470848
145Galactose metabolism_Homo sapiens_hsa000520.07341833
146Influenza A_Homo sapiens_hsa051640.05172506
147Legionellosis_Homo sapiens_hsa051340.04825894
148Carbon metabolism_Homo sapiens_hsa012000.04241172
149Synaptic vesicle cycle_Homo sapiens_hsa047210.03677979
150Endometrial cancer_Homo sapiens_hsa052130.02206057
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00891338
152Selenocompound metabolism_Homo sapiens_hsa00450-0.0053074

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