MED15P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.35128045
2fucose catabolic process (GO:0019317)3.93308035
3L-fucose metabolic process (GO:0042354)3.93308035
4L-fucose catabolic process (GO:0042355)3.93308035
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89929938
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.89929938
7NADH dehydrogenase complex assembly (GO:0010257)3.89929938
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83711892
9protein complex biogenesis (GO:0070271)3.71327555
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67922955
11ATP synthesis coupled proton transport (GO:0015986)3.67922955
12negative regulation of telomere maintenance (GO:0032205)3.66051087
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63823938
14platelet dense granule organization (GO:0060155)3.62970059
15protein-cofactor linkage (GO:0018065)3.61990402
16mitochondrial respiratory chain complex assembly (GO:0033108)3.50212394
17cellular ketone body metabolic process (GO:0046950)3.38068469
18water-soluble vitamin biosynthetic process (GO:0042364)3.27547202
19respiratory chain complex IV assembly (GO:0008535)3.27197501
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24620227
21indolalkylamine metabolic process (GO:0006586)3.23450182
22epithelial cilium movement (GO:0003351)3.22058686
23postsynaptic membrane organization (GO:0001941)3.17923254
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.16612447
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14637493
26DNA deamination (GO:0045006)3.10588109
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.10354168
28kidney morphogenesis (GO:0060993)3.09642229
29nephron epithelium morphogenesis (GO:0072088)3.05410490
30nephron tubule morphogenesis (GO:0072078)3.05410490
31positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.99278027
32ketone body metabolic process (GO:1902224)2.97959830
33pyrimidine nucleobase catabolic process (GO:0006208)2.93017835
34presynaptic membrane assembly (GO:0097105)2.92669416
35pseudouridine synthesis (GO:0001522)2.92350138
36neuronal action potential (GO:0019228)2.89400271
37detection of light stimulus involved in visual perception (GO:0050908)2.87359625
38detection of light stimulus involved in sensory perception (GO:0050962)2.87359625
39nonmotile primary cilium assembly (GO:0035058)2.87132754
40electron transport chain (GO:0022900)2.86743308
41atrial cardiac muscle cell action potential (GO:0086014)2.85605278
42cytochrome complex assembly (GO:0017004)2.85602589
43indole-containing compound catabolic process (GO:0042436)2.85417503
44indolalkylamine catabolic process (GO:0046218)2.85417503
45tryptophan catabolic process (GO:0006569)2.85417503
46positive regulation of sodium ion transmembrane transport (GO:1902307)2.85023334
47piRNA metabolic process (GO:0034587)2.83636242
48preassembly of GPI anchor in ER membrane (GO:0016254)2.81067041
49neuron fate determination (GO:0048664)2.79491218
50axonemal dynein complex assembly (GO:0070286)2.78615015
51kynurenine metabolic process (GO:0070189)2.77637177
52respiratory electron transport chain (GO:0022904)2.77240313
53cilium movement (GO:0003341)2.77234311
54sulfation (GO:0051923)2.76208982
55response to pheromone (GO:0019236)2.72986031
56indole-containing compound metabolic process (GO:0042430)2.72327885
57cornea development in camera-type eye (GO:0061303)2.71614758
58primary amino compound metabolic process (GO:1901160)2.70865844
59behavioral response to ethanol (GO:0048149)2.69245866
60adult feeding behavior (GO:0008343)2.69083032
61nucleobase catabolic process (GO:0046113)2.65939127
62synaptic transmission, cholinergic (GO:0007271)2.65544121
63axoneme assembly (GO:0035082)2.65226134
64sequestering of actin monomers (GO:0042989)2.63884798
65protein neddylation (GO:0045116)2.63728028
66regulation of cilium movement (GO:0003352)2.62829242
67cilium morphogenesis (GO:0060271)2.62521961
68regulation of mesoderm development (GO:2000380)2.61817216
69negative regulation of DNA-dependent DNA replication (GO:2000104)2.59692291
70somite development (GO:0061053)2.59355564
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58716548
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58716548
73serotonin metabolic process (GO:0042428)2.58017352
74negative regulation of interleukin-1 beta production (GO:0032691)2.57700859
75presynaptic membrane organization (GO:0097090)2.57538977
76protein localization to cilium (GO:0061512)2.56884734
77startle response (GO:0001964)2.54865426
78protein polyglutamylation (GO:0018095)2.54488670
79tryptophan metabolic process (GO:0006568)2.53193300
80cilium organization (GO:0044782)2.51990076
81regulation of microtubule-based movement (GO:0060632)2.51820196
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51496668
83regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50873518
84replication fork processing (GO:0031297)2.50840365
85multicellular organism reproduction (GO:0032504)2.50728069
86rhodopsin mediated signaling pathway (GO:0016056)2.50537328
87cilium or flagellum-dependent cell motility (GO:0001539)2.50213944
88ubiquinone biosynthetic process (GO:0006744)2.50032719
89regulation of telomere maintenance (GO:0032204)2.49812942
90regulation of action potential (GO:0098900)2.45288486
91positive regulation of gastrulation (GO:2000543)2.45149307
92auditory behavior (GO:0031223)2.44008772
93hydrogen ion transmembrane transport (GO:1902600)2.43948424
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43647077
95cilium assembly (GO:0042384)2.42976054
96proton transport (GO:0015992)2.42804460
97hindbrain development (GO:0030902)2.40486603
98male meiosis I (GO:0007141)2.40474072
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39607554
100regulation of translation, ncRNA-mediated (GO:0045974)2.39607554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.15430662
2EZH2_22144423_ChIP-Seq_EOC_Human4.04169607
3VDR_22108803_ChIP-Seq_LS180_Human3.62536558
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76469350
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60256078
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53983524
7GBX2_23144817_ChIP-Seq_PC3_Human2.53467124
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.37543901
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28893576
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27773960
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23680026
12IGF1R_20145208_ChIP-Seq_DFB_Human2.22519557
13FUS_26573619_Chip-Seq_HEK293_Human2.14048798
14EWS_26573619_Chip-Seq_HEK293_Human1.99340726
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96702849
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96568523
17P300_19829295_ChIP-Seq_ESCs_Human1.95361768
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.93905233
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88941850
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85100617
21ER_23166858_ChIP-Seq_MCF-7_Human1.83698726
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82750157
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.78595369
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.78290099
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.75440710
26TAF15_26573619_Chip-Seq_HEK293_Human1.74819076
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71830290
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.69784078
29REST_21632747_ChIP-Seq_MESCs_Mouse1.66457858
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63558624
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60819054
32AR_21572438_ChIP-Seq_LNCaP_Human1.57982041
33TP53_22573176_ChIP-Seq_HFKS_Human1.55389332
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53318242
35RNF2_27304074_Chip-Seq_NSC_Mouse1.51696363
36MYC_18940864_ChIP-ChIP_HL60_Human1.51235219
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49028501
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49028501
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.46910340
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44431086
41IRF1_19129219_ChIP-ChIP_H3396_Human1.41529927
42BCAT_22108803_ChIP-Seq_LS180_Human1.40620830
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.37955177
44AR_25329375_ChIP-Seq_VCAP_Human1.33205947
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.32711609
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32370410
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28598896
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28483616
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28391323
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.28391323
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28334298
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.26497855
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23317359
54STAT3_23295773_ChIP-Seq_U87_Human1.23251261
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22650423
56SMAD4_21799915_ChIP-Seq_A2780_Human1.22373054
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.22353566
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21261696
59CBP_20019798_ChIP-Seq_JUKART_Human1.21203498
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21203498
61NANOG_19829295_ChIP-Seq_ESCs_Human1.20808347
62SOX2_19829295_ChIP-Seq_ESCs_Human1.20808347
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17642791
64TCF4_23295773_ChIP-Seq_U87_Human1.17006100
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15424439
66TCF4_22108803_ChIP-Seq_LS180_Human1.15366869
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.14875852
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13810218
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13174629
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.12753381
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.12426125
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10634350
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10631531
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09950483
75RUNX2_22187159_ChIP-Seq_PCA_Human1.09637617
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09151917
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08370659
78ERA_21632823_ChIP-Seq_H3396_Human1.06853553
79HOXB7_26014856_ChIP-Seq_BT474_Human1.05700780
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03673901
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02701373
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.02041599
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01920991
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01915641
85AR_20517297_ChIP-Seq_VCAP_Human1.00862022
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00641330
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00244416
88NCOR_22424771_ChIP-Seq_293T_Human0.99843167
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99833966
90MYC_19829295_ChIP-Seq_ESCs_Human0.99792267
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98892833
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.98763495
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98740783
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98106547
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96605510
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95740218
97ELK1_19687146_ChIP-ChIP_HELA_Human0.95356567
98VDR_23849224_ChIP-Seq_CD4+_Human0.95194350
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.94970685
100TAF2_19829295_ChIP-Seq_ESCs_Human0.93898655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation2.67664756
2MP0002102_abnormal_ear_morphology2.55706256
3MP0006292_abnormal_olfactory_placode2.54138497
4MP0008877_abnormal_DNA_methylation2.39467551
5MP0003195_calcinosis2.37656463
6MP0002653_abnormal_ependyma_morphology2.36133434
7MP0003136_yellow_coat_color2.35764469
8MP0004147_increased_porphyrin_level2.31256845
9MP0000569_abnormal_digit_pigmentation2.25680344
10MP0005551_abnormal_eye_electrophysiolog2.25576774
11MP0001968_abnormal_touch/_nociception2.13966678
12MP0003880_abnormal_central_pattern2.12358856
13MP0002736_abnormal_nociception_after2.05887937
14MP0008872_abnormal_physiological_respon2.01397968
15MP0009046_muscle_twitch1.94047706
16MP0002837_dystrophic_cardiac_calcinosis1.93026487
17MP0004133_heterotaxia1.90792064
18MP0002938_white_spotting1.89147303
19MP0002638_abnormal_pupillary_reflex1.84891779
20MP0009745_abnormal_behavioral_response1.84538000
21MP0004885_abnormal_endolymph1.76930213
22MP0005645_abnormal_hypothalamus_physiol1.74477867
23MP0003011_delayed_dark_adaptation1.74406081
24MP0001986_abnormal_taste_sensitivity1.74010884
25MP0005646_abnormal_pituitary_gland1.73083744
26MP0002272_abnormal_nervous_system1.69692465
27MP0004145_abnormal_muscle_electrophysio1.67838603
28MP0001529_abnormal_vocalization1.66711183
29MP0008875_abnormal_xenobiotic_pharmacok1.66109860
30MP0006072_abnormal_retinal_apoptosis1.65777321
31MP0006276_abnormal_autonomic_nervous1.65422627
32MP0003283_abnormal_digestive_organ1.65384242
33MP0004142_abnormal_muscle_tone1.64106541
34MP0003646_muscle_fatigue1.63284422
35MP0002876_abnormal_thyroid_physiology1.59936702
36MP0000631_abnormal_neuroendocrine_gland1.58173609
37MP0003890_abnormal_embryonic-extraembry1.57413506
38MP0001486_abnormal_startle_reflex1.56917355
39MP0003787_abnormal_imprinting1.56227181
40MP0005084_abnormal_gallbladder_morpholo1.56042167
41MP0002572_abnormal_emotion/affect_behav1.53432378
42MP0002557_abnormal_social/conspecific_i1.51576701
43MP0002735_abnormal_chemical_nociception1.50337263
44MP0005253_abnormal_eye_physiology1.50041691
45MP0002064_seizures1.48067513
46MP0008995_early_reproductive_senescence1.48023711
47MP0005174_abnormal_tail_pigmentation1.42684601
48MP0001485_abnormal_pinna_reflex1.39673770
49MP0004742_abnormal_vestibular_system1.37832913
50MP0000427_abnormal_hair_cycle1.35509208
51MP0001501_abnormal_sleep_pattern1.32521514
52MP0002928_abnormal_bile_duct1.32133151
53MP0004924_abnormal_behavior1.23662388
54MP0005386_behavior/neurological_phenoty1.23662388
55MP0001970_abnormal_pain_threshold1.21087989
56MP0002277_abnormal_respiratory_mucosa1.20826730
57MP0002067_abnormal_sensory_capabilities1.20671462
58MP0003635_abnormal_synaptic_transmissio1.20496907
59MP0002733_abnormal_thermal_nociception1.20309489
60MP0002160_abnormal_reproductive_system1.19264296
61MP0004043_abnormal_pH_regulation1.19045917
62MP0001905_abnormal_dopamine_level1.17747772
63MP0005423_abnormal_somatic_nervous1.17202122
64MP0003119_abnormal_digestive_system1.16634053
65MP0002234_abnormal_pharynx_morphology1.15633564
66MP0002063_abnormal_learning/memory/cond1.15507305
67MP0000778_abnormal_nervous_system1.15437985
68MP0000372_irregular_coat_pigmentation1.13455483
69MP0005389_reproductive_system_phenotype1.11710922
70MP0005377_hearing/vestibular/ear_phenot1.10277669
71MP0003878_abnormal_ear_physiology1.10277669
72MP0000026_abnormal_inner_ear1.09603534
73MP0001984_abnormal_olfaction1.09137255
74MP0001919_abnormal_reproductive_system1.08647558
75MP0001293_anophthalmia1.07740835
76MP0002734_abnormal_mechanical_nocicepti1.06313836
77MP0000647_abnormal_sebaceous_gland1.05683164
78MP0002095_abnormal_skin_pigmentation1.04135485
79MP0005195_abnormal_posterior_eye1.01173538
80MP0005167_abnormal_blood-brain_barrier0.98783626
81MP0000566_synostosis0.98720940
82MP0002184_abnormal_innervation0.97728533
83MP0003718_maternal_effect0.97532362
84MP0002752_abnormal_somatic_nervous0.96445687
85MP0000383_abnormal_hair_follicle0.92215363
86MP0001188_hyperpigmentation0.91146402
87MP0002751_abnormal_autonomic_nervous0.89596200
88MP0003122_maternal_imprinting0.89042081
89MP0005410_abnormal_fertilization0.88511529
90MP0003698_abnormal_male_reproductive0.88189919
91MP0008058_abnormal_DNA_repair0.87486688
92MP0000049_abnormal_middle_ear0.86361912
93MP0001502_abnormal_circadian_rhythm0.85486024
94MP0003937_abnormal_limbs/digits/tail_de0.84044284
95MP0001963_abnormal_hearing_physiology0.83948060
96MP0003121_genomic_imprinting0.83741347
97MP0003567_abnormal_fetal_cardiomyocyte0.82701660
98MP0003938_abnormal_ear_development0.82598752
99MP0008775_abnormal_heart_ventricle0.81820900
100MP0002210_abnormal_sex_determination0.81730553

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.26036354
2Pancreatic cysts (HP:0001737)4.12256276
3Molar tooth sign on MRI (HP:0002419)4.02457109
4Abnormality of midbrain morphology (HP:0002418)4.02457109
5Pancreatic fibrosis (HP:0100732)3.91560932
6Birth length less than 3rd percentile (HP:0003561)3.76691802
7True hermaphroditism (HP:0010459)3.72433559
8Congenital stationary night blindness (HP:0007642)3.60859265
9Nephronophthisis (HP:0000090)3.54244850
10Chronic hepatic failure (HP:0100626)3.52694355
11Pendular nystagmus (HP:0012043)3.18391617
12Hyperventilation (HP:0002883)2.99294676
13Absent/shortened dynein arms (HP:0200106)2.99106281
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.99106281
15Increased corneal curvature (HP:0100692)2.91752656
16Keratoconus (HP:0000563)2.91752656
17Abnormality of the renal medulla (HP:0100957)2.86594870
18Concave nail (HP:0001598)2.79009773
19Abnormality of the renal cortex (HP:0011035)2.76502446
20Patellar aplasia (HP:0006443)2.76003638
21Lissencephaly (HP:0001339)2.70431244
22Abnormal respiratory motile cilium morphology (HP:0005938)2.69555163
23Abnormal respiratory epithelium morphology (HP:0012253)2.69555163
24Cerebellar dysplasia (HP:0007033)2.68849854
25Acute necrotizing encephalopathy (HP:0006965)2.63463654
26Aplasia/Hypoplasia of the patella (HP:0006498)2.60846965
27Attenuation of retinal blood vessels (HP:0007843)2.57811504
28Retinal dysplasia (HP:0007973)2.54086330
29Abnormality of the pons (HP:0007361)2.50998968
30Cystic liver disease (HP:0006706)2.49210317
31Mitochondrial inheritance (HP:0001427)2.48785574
32Abnormal number of erythroid precursors (HP:0012131)2.47578984
33Tubular atrophy (HP:0000092)2.45594907
34Decreased central vision (HP:0007663)2.44911478
35Congenital, generalized hypertrichosis (HP:0004540)2.41991842
36Abnormal ciliary motility (HP:0012262)2.41784741
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41077898
38Abnormality of alanine metabolism (HP:0010916)2.41077898
39Hyperalaninemia (HP:0003348)2.41077898
40Sclerocornea (HP:0000647)2.41056660
413-Methylglutaconic aciduria (HP:0003535)2.40211909
42Medial flaring of the eyebrow (HP:0010747)2.38026526
43Hypothermia (HP:0002045)2.34624958
44Hypoplasia of the pons (HP:0012110)2.34448862
45Lipid accumulation in hepatocytes (HP:0006561)2.33322891
46Abnormal drinking behavior (HP:0030082)2.33249001
47Polydipsia (HP:0001959)2.33249001
48Abnormal rod and cone electroretinograms (HP:0008323)2.32776039
49Anencephaly (HP:0002323)2.30903705
50Abnormal respiratory motile cilium physiology (HP:0012261)2.27729100
51Acute encephalopathy (HP:0006846)2.27559256
52Increased hepatocellular lipid droplets (HP:0006565)2.27125116
53Large for gestational age (HP:0001520)2.25192570
54Increased CSF lactate (HP:0002490)2.25021077
55Abolished electroretinogram (ERG) (HP:0000550)2.23694130
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23206832
57Progressive macrocephaly (HP:0004481)2.22506297
58Abnormal mitochondria in muscle tissue (HP:0008316)2.17028318
59Inability to walk (HP:0002540)2.16821688
60Methylmalonic acidemia (HP:0002912)2.15903158
61Abnormality of cells of the erythroid lineage (HP:0012130)2.15550010
62Optic disc pallor (HP:0000543)2.10565181
63Bile duct proliferation (HP:0001408)2.09621521
64Abnormal biliary tract physiology (HP:0012439)2.09621521
65Male pseudohermaphroditism (HP:0000037)2.03060548
66Broad-based gait (HP:0002136)2.02495249
67Furrowed tongue (HP:0000221)2.01335973
68Optic nerve hypoplasia (HP:0000609)2.00471463
69Abnormality of the labia minora (HP:0012880)1.98322162
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.98197613
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97386594
72Gait imbalance (HP:0002141)1.95813247
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94791650
74Renal cortical cysts (HP:0000803)1.93061202
75Breast hypoplasia (HP:0003187)1.91658125
76Pachygyria (HP:0001302)1.91411223
77Polyuria (HP:0000103)1.89248245
78Progressive cerebellar ataxia (HP:0002073)1.89077960
79Protruding tongue (HP:0010808)1.85406355
80Chorioretinal atrophy (HP:0000533)1.82964816
81Scrotal hypoplasia (HP:0000046)1.82549092
82Limb dystonia (HP:0002451)1.81330284
83Hepatocellular necrosis (HP:0001404)1.80927876
84Congenital primary aphakia (HP:0007707)1.79885936
85Congenital hepatic fibrosis (HP:0002612)1.78446424
86Oligodactyly (hands) (HP:0001180)1.77029308
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76933027
88Severe muscular hypotonia (HP:0006829)1.74967566
89Anophthalmia (HP:0000528)1.74620716
90Postaxial foot polydactyly (HP:0001830)1.74223597
91Microretrognathia (HP:0000308)1.74186316
92Stomach cancer (HP:0012126)1.73141209
93Hepatic necrosis (HP:0002605)1.72825650
94Dandy-Walker malformation (HP:0001305)1.72473502
95Renal Fanconi syndrome (HP:0001994)1.67888435
96Rhinitis (HP:0012384)1.66914541
97Myokymia (HP:0002411)1.66324508
98Bony spicule pigmentary retinopathy (HP:0007737)1.65905549
99Nephrogenic diabetes insipidus (HP:0009806)1.65326058
100Methylmalonic aciduria (HP:0012120)1.65139624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.60443416
2BMPR1B3.30169102
3FRK3.18378047
4ADRBK22.92310055
5CASK2.90970388
6WNK32.84431858
7INSRR2.77335013
8TLK12.76352853
9GRK12.51038015
10WNK42.46561088
11ACVR1B2.31155312
12MAPK132.23091712
13MAPK152.13360464
14MAP4K22.10710978
15PINK11.98394530
16PNCK1.97825212
17MARK11.88113728
18TNIK1.87251233
19CAMKK21.78381001
20DAPK21.78252034
21DYRK21.78130728
22NUAK11.66698840
23NME11.66530935
24TGFBR11.65349076
25MKNK21.49438309
26TAOK31.44679090
27VRK11.33087427
28MAP3K41.32480728
29NTRK31.32369011
30OXSR11.28299808
31ADRBK11.21670558
32MAP2K61.03264713
33NTRK21.02518925
34WEE11.01219161
35MKNK10.98157126
36STK390.98072349
37CAMKK10.96616509
38PAK30.95769828
39PHKG10.95092389
40PHKG20.95092389
41PRKCG0.94232492
42NEK20.91347748
43SIK20.85590682
44TXK0.85326737
45RPS6KA50.78981517
46MAP2K70.78762294
47TSSK60.78735669
48STK160.77302617
49CAMK2A0.72937869
50CDK190.72529129
51PRKCE0.71741668
52PLK30.71207683
53PASK0.68147108
54TIE10.62979960
55CAMK10.62035835
56MUSK0.59074256
57TRIM280.58941955
58MAPKAPK30.57846762
59PLK40.57642511
60VRK20.56651813
61EPHA40.54041880
62PTK2B0.53759968
63BCKDK0.53598663
64PKN10.52837289
65MAPKAPK50.52708834
66CSNK1G20.52217057
67PRKACA0.52131519
68TEC0.51876671
69STK38L0.51296079
70CAMK1D0.50170644
71PIK3CA0.49991815
72IKBKB0.49978195
73BUB10.49642556
74PLK20.46389203
75PLK10.46059615
76CDC70.45456328
77PRKCZ0.45006097
78DYRK30.43853010
79PRKCQ0.43428393
80FGFR20.43002278
81CSNK1A10.42005453
82CAMK1G0.41673169
83MINK10.38079165
84RPS6KA60.38006702
85MAP2K40.37321464
86CAMK40.36967353
87CSNK1G30.36782783
88PRKG10.36779160
89IRAK10.36400818
90STK110.35707004
91CSNK1G10.35624237
92CHUK0.35042883
93CHEK20.34732363
94TAF10.34574391
95TYRO30.34547676
96PRKCA0.32191179
97PRKCI0.31227139
98CDK30.29973427
99ATR0.27420423
100MAP3K120.27413978

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.18955201
2Phototransduction_Homo sapiens_hsa047442.61242237
3Protein export_Homo sapiens_hsa030602.59875458
4Parkinsons disease_Homo sapiens_hsa050122.59780020
5Linoleic acid metabolism_Homo sapiens_hsa005912.56325167
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43375289
7Nicotine addiction_Homo sapiens_hsa050332.41129196
8Ribosome_Homo sapiens_hsa030102.41114074
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.26052555
10Butanoate metabolism_Homo sapiens_hsa006502.20733411
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18691771
12Selenocompound metabolism_Homo sapiens_hsa004502.14335233
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10030581
14Nitrogen metabolism_Homo sapiens_hsa009102.09399147
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03860286
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00913742
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99518052
18Homologous recombination_Homo sapiens_hsa034401.96777135
19Huntingtons disease_Homo sapiens_hsa050161.79752072
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79359947
21RNA polymerase_Homo sapiens_hsa030201.76411902
22Cardiac muscle contraction_Homo sapiens_hsa042601.75591781
23Alzheimers disease_Homo sapiens_hsa050101.70052714
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69456136
25Ether lipid metabolism_Homo sapiens_hsa005651.66261288
26Basal transcription factors_Homo sapiens_hsa030221.61085431
27Tryptophan metabolism_Homo sapiens_hsa003801.53873962
28Caffeine metabolism_Homo sapiens_hsa002321.47921674
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47076243
30Fanconi anemia pathway_Homo sapiens_hsa034601.45175261
31Olfactory transduction_Homo sapiens_hsa047401.30252939
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.25006605
33Taste transduction_Homo sapiens_hsa047421.23284803
34One carbon pool by folate_Homo sapiens_hsa006701.16015308
35Sulfur relay system_Homo sapiens_hsa041221.14059942
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10655385
37Morphine addiction_Homo sapiens_hsa050321.10603720
38RNA degradation_Homo sapiens_hsa030181.07905029
39ABC transporters_Homo sapiens_hsa020101.02096687
40Propanoate metabolism_Homo sapiens_hsa006401.00380155
41Chemical carcinogenesis_Homo sapiens_hsa052040.99122731
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.98672829
43Peroxisome_Homo sapiens_hsa041460.95008715
44Vitamin digestion and absorption_Homo sapiens_hsa049770.94692703
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94176884
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93407456
47Serotonergic synapse_Homo sapiens_hsa047260.90977391
48Retinol metabolism_Homo sapiens_hsa008300.90525379
49GABAergic synapse_Homo sapiens_hsa047270.89918951
50Proteasome_Homo sapiens_hsa030500.89213718
51Arachidonic acid metabolism_Homo sapiens_hsa005900.87638701
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86236669
53Collecting duct acid secretion_Homo sapiens_hsa049660.85760938
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85430067
55Insulin secretion_Homo sapiens_hsa049110.84572884
56Circadian entrainment_Homo sapiens_hsa047130.84308010
57Glutamatergic synapse_Homo sapiens_hsa047240.83874070
58Cocaine addiction_Homo sapiens_hsa050300.83810549
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.83598299
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78822882
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78470238
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75683721
63Regulation of autophagy_Homo sapiens_hsa041400.74750483
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73431501
65Purine metabolism_Homo sapiens_hsa002300.71264972
66Nucleotide excision repair_Homo sapiens_hsa034200.69198070
67Fat digestion and absorption_Homo sapiens_hsa049750.67615134
68Metabolic pathways_Homo sapiens_hsa011000.66951389
69Asthma_Homo sapiens_hsa053100.65927294
70Calcium signaling pathway_Homo sapiens_hsa040200.61569221
71Ovarian steroidogenesis_Homo sapiens_hsa049130.60758870
72Steroid biosynthesis_Homo sapiens_hsa001000.55802310
73Hedgehog signaling pathway_Homo sapiens_hsa043400.55578401
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54747191
75Amphetamine addiction_Homo sapiens_hsa050310.53913226
76Basal cell carcinoma_Homo sapiens_hsa052170.53017583
77beta-Alanine metabolism_Homo sapiens_hsa004100.51670834
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50495564
79Pyrimidine metabolism_Homo sapiens_hsa002400.50294159
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.49078489
81Glycerolipid metabolism_Homo sapiens_hsa005610.48215784
82Dopaminergic synapse_Homo sapiens_hsa047280.46428422
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44501430
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42701268
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41708430
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41373353
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40552189
88Base excision repair_Homo sapiens_hsa034100.39712591
89Mineral absorption_Homo sapiens_hsa049780.38397925
90Non-homologous end-joining_Homo sapiens_hsa034500.37973653
91Fatty acid biosynthesis_Homo sapiens_hsa000610.37646127
92Salivary secretion_Homo sapiens_hsa049700.37387674
93Histidine metabolism_Homo sapiens_hsa003400.37168975
94Sulfur metabolism_Homo sapiens_hsa009200.36794014
95RNA transport_Homo sapiens_hsa030130.36329834
96Primary immunodeficiency_Homo sapiens_hsa053400.34790688
97Long-term depression_Homo sapiens_hsa047300.34609886
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34033942
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.32025803
100cAMP signaling pathway_Homo sapiens_hsa040240.29363676

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