MED14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.81102416
2nuclear pore complex assembly (GO:0051292)4.88912957
3NLS-bearing protein import into nucleus (GO:0006607)4.30326296
4nuclear pore organization (GO:0006999)4.27874180
5paraxial mesoderm development (GO:0048339)4.01381913
6DNA synthesis involved in DNA repair (GO:0000731)3.95087717
7regulation of RNA export from nucleus (GO:0046831)3.91879054
8pre-miRNA processing (GO:0031054)3.82618554
9glucocorticoid receptor signaling pathway (GO:0042921)3.76502281
10heterochromatin organization (GO:0070828)3.75516450
11protein localization to kinetochore (GO:0034501)3.75011333
12mitotic chromosome condensation (GO:0007076)3.74025933
13cytoplasmic mRNA processing body assembly (GO:0033962)3.72697715
14sister chromatid segregation (GO:0000819)3.68617394
15corticosteroid receptor signaling pathway (GO:0031958)3.53234042
16synapsis (GO:0007129)3.47212513
17chromosome condensation (GO:0030261)3.36115667
18meiotic chromosome segregation (GO:0045132)3.34823061
19regulation of nucleobase-containing compound transport (GO:0032239)3.34002268
20regulation of DNA endoreduplication (GO:0032875)3.30402644
21protein localization to chromosome, centromeric region (GO:0071459)3.30065497
22protein complex localization (GO:0031503)3.24119791
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23843654
24regulation of spindle organization (GO:0090224)3.23746742
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23415383
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.23415383
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23415383
28regulation of sister chromatid cohesion (GO:0007063)3.21811290
29pore complex assembly (GO:0046931)3.21211095
30nuclear envelope disassembly (GO:0051081)3.20848309
31membrane disassembly (GO:0030397)3.20848309
32mitotic nuclear envelope disassembly (GO:0007077)3.18690239
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12503531
34negative regulation of DNA repair (GO:0045738)3.12184589
35DNA strand elongation involved in DNA replication (GO:0006271)3.10117491
36mitotic sister chromatid segregation (GO:0000070)3.08718489
37establishment of integrated proviral latency (GO:0075713)3.06520132
38negative regulation of histone methylation (GO:0031061)3.05541884
39regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03352982
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03352982
41cellular protein complex localization (GO:0034629)3.03310509
42regulation of mitotic sister chromatid segregation (GO:0033047)3.02447441
43regulation of sister chromatid segregation (GO:0033045)3.02447441
44regulation of mitotic sister chromatid separation (GO:0010965)3.02447441
45negative regulation of chromosome segregation (GO:0051985)3.01731351
46DNA strand elongation (GO:0022616)3.01705219
47regulation of mitotic spindle organization (GO:0060236)3.01204789
48DNA replication initiation (GO:0006270)2.97557218
49histone H3-K4 trimethylation (GO:0080182)2.97172884
50DNA packaging (GO:0006323)2.96950613
51DNA conformation change (GO:0071103)2.96477607
52histone H2A monoubiquitination (GO:0035518)2.95552249
53mitotic spindle checkpoint (GO:0071174)2.94921854
54regulation of chromatin silencing (GO:0031935)2.94452122
55spindle checkpoint (GO:0031577)2.94390526
56protein export from nucleus (GO:0006611)2.93543084
57nucleosome disassembly (GO:0006337)2.92485801
58protein-DNA complex disassembly (GO:0032986)2.92485801
59positive regulation of chromosome segregation (GO:0051984)2.91053276
60negative regulation of sister chromatid segregation (GO:0033046)2.90682934
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90682934
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90682934
63negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90682934
64negative regulation of mitotic sister chromatid separation (GO:2000816)2.90682934
65peptidyl-lysine dimethylation (GO:0018027)2.90669020
66establishment of chromosome localization (GO:0051303)2.89666861
67non-recombinational repair (GO:0000726)2.87189913
68double-strand break repair via nonhomologous end joining (GO:0006303)2.87189913
69chromosome organization involved in meiosis (GO:0070192)2.86279993
70nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.85837763
71regulation of posttranscriptional gene silencing (GO:0060147)2.82193230
72regulation of gene silencing by miRNA (GO:0060964)2.82193230
73regulation of gene silencing by RNA (GO:0060966)2.82193230
74mitotic spindle assembly checkpoint (GO:0007094)2.81084763
75IMP metabolic process (GO:0046040)2.79892211
76positive regulation of SMAD protein import into nucleus (GO:0060391)2.79146051
77DNA unwinding involved in DNA replication (GO:0006268)2.78750812
78regulation of clathrin-mediated endocytosis (GO:2000369)2.76985496
79mRNA transport (GO:0051028)2.75002962
80monoubiquitinated protein deubiquitination (GO:0035520)2.74736347
81spindle assembly checkpoint (GO:0071173)2.73440932
82regulation of translational termination (GO:0006449)2.72080055
83ATP-dependent chromatin remodeling (GO:0043044)2.70867472
84chromatin assembly (GO:0031497)2.70049884
85IMP biosynthetic process (GO:0006188)2.68977382
86regulation of NFAT protein import into nucleus (GO:0051532)2.68142107
87chromosome segregation (GO:0007059)2.67962971
88nuclear envelope organization (GO:0006998)2.67879438
89negative T cell selection (GO:0043383)2.66214960
90peptidyl-threonine phosphorylation (GO:0018107)2.65844117
91protein localization to chromosome (GO:0034502)2.64887578
92regulation of histone methylation (GO:0031060)2.63407731
93peptidyl-threonine modification (GO:0018210)2.63317440
94regulation of gene silencing (GO:0060968)2.62440627
95trophectodermal cell differentiation (GO:0001829)2.62188739
96histone H3-K4 methylation (GO:0051568)2.62138251
97establishment of nucleus localization (GO:0040023)2.60538374
98positive T cell selection (GO:0043368)2.59313554
99kinetochore organization (GO:0051383)2.58018544
100mitotic metaphase plate congression (GO:0007080)2.57557909
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56812682
102negative regulation of cell killing (GO:0031342)2.56812682
103sister chromatid cohesion (GO:0007062)2.53881334
104negative thymic T cell selection (GO:0045060)2.52506704
105dosage compensation (GO:0007549)2.48992889
106histone H3-K9 demethylation (GO:0033169)2.47316467
107RNA stabilization (GO:0043489)2.47191844
108mRNA stabilization (GO:0048255)2.47191844
109peptidyl-lysine trimethylation (GO:0018023)2.46152180
110histone H3-K36 demethylation (GO:0070544)2.45343791
111regulation of transforming growth factor beta2 production (GO:0032909)2.44814076
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44378867
113positive regulation of DNA-templated transcription, initiation (GO:2000144)2.42722021
114histone lysine methylation (GO:0034968)2.42390715
115DNA duplex unwinding (GO:0032508)2.39252078
116alternative mRNA splicing, via spliceosome (GO:0000380)2.37058462
117DNA geometric change (GO:0032392)2.36094200
118hippo signaling (GO:0035329)2.34683767
119sodium ion export (GO:0071436)2.33730312
120attachment of spindle microtubules to kinetochore (GO:0008608)2.32367301
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.32291944
122thymic T cell selection (GO:0045061)2.32208449
123T cell selection (GO:0045058)2.31653536
124histone H4-K16 acetylation (GO:0043984)2.31573147
125peptidyl-lysine methylation (GO:0018022)2.30595090
126histone phosphorylation (GO:0016572)2.30453859
127negative regulation of RNA splicing (GO:0033119)2.28942186
128gene silencing by RNA (GO:0031047)2.27928662
129metaphase plate congression (GO:0051310)2.27595977
130histone methylation (GO:0016571)2.27326854
131microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.26808482
132DNA topological change (GO:0006265)2.26493755
133positive thymic T cell selection (GO:0045059)2.24272554
134nuclear import (GO:0051170)2.24263801
135negative regulation of fibroblast apoptotic process (GO:2000270)2.24172451
136regulation of chromosome segregation (GO:0051983)2.23938442
137positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.22919897
138regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.22919897
139regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.22677763
140positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.22677763
141protein import into nucleus (GO:0006606)2.21748467
142single-organism nuclear import (GO:1902593)2.21748467
143regulation of mRNA stability (GO:0043488)2.20724785
144locomotory exploration behavior (GO:0035641)2.20090213
145positive regulation of gene expression, epigenetic (GO:0045815)2.19680509
146histone H2A ubiquitination (GO:0033522)2.19204369
147regulation of histone H3-K9 methylation (GO:0051570)2.18855054
148peptidyl-arginine N-methylation (GO:0035246)2.18129002
149peptidyl-arginine methylation (GO:0018216)2.18129002
150histone mRNA catabolic process (GO:0071044)2.18050439
151synaptic vesicle maturation (GO:0016188)2.15051908
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.14729203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89220452
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.86465406
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.82281948
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.11639512
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42380530
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18573734
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06856933
8MYC_22102868_ChIP-Seq_BL_Human3.05290831
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.84709718
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83500565
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73626598
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.52887216
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.45122178
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.36076349
15AR_21909140_ChIP-Seq_LNCAP_Human2.24206842
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23628231
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23628231
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23628231
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10881840
20MYCN_18555785_ChIP-Seq_MESCs_Mouse2.10033679
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03912149
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00430404
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.94434933
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.93444452
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.93319682
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93302278
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.91549103
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87134034
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86754094
30TCF7_22412390_ChIP-Seq_EML_Mouse1.85420640
31CLOCK_20551151_ChIP-Seq_293T_Human1.84354912
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81176566
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74738385
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74294365
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70943192
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68633660
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68304078
38FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.67584128
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65990695
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64519221
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64130893
42KDM2B_26808549_Chip-Seq_DND41_Human1.63119706
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62760346
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62562122
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59751309
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59090205
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55118656
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.52314621
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52162553
50EZH2_22144423_ChIP-Seq_EOC_Human1.50668944
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48260824
52AR_21572438_ChIP-Seq_LNCaP_Human1.46682370
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46680762
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.45659880
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43787561
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43220529
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43097179
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38559032
59TP53_16413492_ChIP-PET_HCT116_Human1.38558904
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35841145
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35491354
62BRD4_25478319_ChIP-Seq_HGPS_Human1.34983685
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30855930
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29937952
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28920009
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28302550
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27605170
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26802217
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25237154
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24082445
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23760641
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.21290961
73* MYB_26560356_Chip-Seq_TH2_Human1.20095245
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18586470
75RUNX_20019798_ChIP-Seq_JUKART_Human1.18088152
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17807821
77UTX_26944678_Chip-Seq_JUKART_Human1.15894389
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15838501
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15753920
80* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14927391
81CHD1_26751641_Chip-Seq_LNCaP_Human1.14567531
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14154582
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14085926
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.13907757
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10250614
86MYB_26560356_Chip-Seq_TH1_Human1.08661551
87FUS_26573619_Chip-Seq_HEK293_Human1.06424863
88KDM2B_26808549_Chip-Seq_K562_Human1.06372101
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05357356
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04374224
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04338976
92VDR_21846776_ChIP-Seq_THP-1_Human1.03876954
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03823351
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.01903426
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01857594
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.01295621
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01026515
98CIITA_25753668_ChIP-Seq_RAJI_Human1.00919920
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00176163
100RARB_27405468_Chip-Seq_BRAIN_Mouse0.97686986
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97317115
102TTF2_22483619_ChIP-Seq_HELA_Human0.96731814
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96238326
104MAF_26560356_Chip-Seq_TH1_Human0.96220052
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94575790
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.93800720
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93636687
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93400138
109TFEB_21752829_ChIP-Seq_HELA_Human0.92790438
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92785246
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92678884
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92318963
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92091690
114* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91771336
115MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91539631
116XRN2_22483619_ChIP-Seq_HELA_Human0.91024411
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90024293
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89782461
119ZNF274_21170338_ChIP-Seq_K562_Hela0.89679716
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89186968
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88853097
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88269334
123CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88002580
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86351321
125KDM5A_27292631_Chip-Seq_BREAST_Human0.86314626
126EWS_26573619_Chip-Seq_HEK293_Human0.85830133
127AR_19668381_ChIP-Seq_PC3_Human0.85160844
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84582932
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.82842318
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.82381931
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82151955
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81480985
133* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81375235
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80780780
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.80636693
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80028053
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79587314
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79394589
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79204141
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78747139
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78510404
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78399647
143RXR_22108803_ChIP-Seq_LS180_Human0.78093944
144THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77329400
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77304620
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76741100
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.76112824
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75848653
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75470980
150GATA3_27048872_Chip-Seq_THYMUS_Human0.75250717
151NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75196318
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74962365
153SPI1_23127762_ChIP-Seq_K562_Human0.74559087
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.73892668
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73703915
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73150638
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73150638
158ATF3_27146783_Chip-Seq_COLON_Human0.72935199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.20752809
2MP0005076_abnormal_cell_differentiation3.10727068
3MP0000569_abnormal_digit_pigmentation2.90125665
4MP0010234_abnormal_vibrissa_follicle2.87311374
5MP0003300_gastrointestinal_ulcer2.75170742
6MP0003111_abnormal_nucleus_morphology2.28821751
7MP0010094_abnormal_chromosome_stability2.27829013
8MP0004859_abnormal_synaptic_plasticity2.24842645
9MP0002396_abnormal_hematopoietic_system2.22620809
10MP0003787_abnormal_imprinting2.15100999
11MP0005409_darkened_coat_color2.08403289
12MP0003705_abnormal_hypodermis_morpholog2.08082804
13MP0004808_abnormal_hematopoietic_stem2.04482772
14MP0003693_abnormal_embryo_hatching2.00034883
15MP0008961_abnormal_basal_metabolism1.99703168
16MP0008058_abnormal_DNA_repair1.95217548
17MP0003077_abnormal_cell_cycle1.92609230
18MP0010307_abnormal_tumor_latency1.90887494
19MP0002166_altered_tumor_susceptibility1.88903126
20MP0010678_abnormal_skin_adnexa1.88071681
21MP0010030_abnormal_orbit_morphology1.86683808
22MP0000383_abnormal_hair_follicle1.83880586
23MP0005187_abnormal_penis_morphology1.82767297
24MP0004957_abnormal_blastocyst_morpholog1.81536124
25MP0002009_preneoplasia1.80567973
26MP0003121_genomic_imprinting1.79423051
27MP0003123_paternal_imprinting1.77403119
28MP0008877_abnormal_DNA_methylation1.70632999
29MP0008057_abnormal_DNA_replication1.67688322
30MP0002877_abnormal_melanocyte_morpholog1.65258175
31MP0000350_abnormal_cell_proliferation1.64276229
32MP0001730_embryonic_growth_arrest1.61017720
33MP0002006_tumorigenesis1.59265059
34MP0002084_abnormal_developmental_patter1.55632647
35MP0009697_abnormal_copulation1.55207127
36MP0000733_abnormal_muscle_development1.53512283
37MP0002088_abnormal_embryonic_growth/wei1.51622022
38MP0003984_embryonic_growth_retardation1.51541302
39MP0005380_embryogenesis_phenotype1.47992196
40MP0001672_abnormal_embryogenesis/_devel1.47992196
41MP0003763_abnormal_thymus_physiology1.47901162
42MP0002697_abnormal_eye_size1.44271731
43MP0003091_abnormal_cell_migration1.43428043
44MP0002086_abnormal_extraembryonic_tissu1.42811732
45MP0000703_abnormal_thymus_morphology1.41615340
46MP0003718_maternal_effect1.39822505
47MP0001697_abnormal_embryo_size1.39444848
48MP0004197_abnormal_fetal_growth/weight/1.37469100
49MP0009780_abnormal_chondrocyte_physiolo1.37343582
50MP0000428_abnormal_craniofacial_morphol1.32903926
51MP0005451_abnormal_body_composition1.32688466
52MP0003890_abnormal_embryonic-extraembry1.31816063
53MP0002796_impaired_skin_barrier1.30955866
54MP0001299_abnormal_eye_distance/1.28914067
55MP0002085_abnormal_embryonic_tissue1.27537352
56MP0001346_abnormal_lacrimal_gland1.27398233
57MP0003303_peritoneal_inflammation1.27055219
58MP0003566_abnormal_cell_adhesion1.19614315
59MP0003935_abnormal_craniofacial_develop1.18134579
60MP0009703_decreased_birth_body1.17187488
61MP0009053_abnormal_anal_canal1.16316524
62MP0003115_abnormal_respiratory_system1.15903040
63MP0001915_intracranial_hemorrhage1.15564066
64MP0009672_abnormal_birth_weight1.13943472
65MP0005623_abnormal_meninges_morphology1.12584812
66MP0000537_abnormal_urethra_morphology1.10312849
67MP0004233_abnormal_muscle_weight1.08704223
68MP0002089_abnormal_postnatal_growth/wei1.08530722
69MP0000762_abnormal_tongue_morphology1.08087771
70MP0004087_abnormal_muscle_fiber1.07300029
71MP0002080_prenatal_lethality1.07024804
72MP0002925_abnormal_cardiovascular_devel1.04302449
73MP0004272_abnormal_basement_membrane1.03770499
74MP0001286_abnormal_eye_development1.02046739
75MP0005501_abnormal_skin_physiology1.01211682
76MP0001545_abnormal_hematopoietic_system1.00710341
77MP0005397_hematopoietic_system_phenotyp1.00710341
78MP0000678_abnormal_parathyroid_gland0.99804410
79MP0002254_reproductive_system_inflammat0.98784880
80MP0008007_abnormal_cellular_replicative0.97869794
81MP0000313_abnormal_cell_death0.97779607
82MP0001188_hyperpigmentation0.94698509
83MP0000377_abnormal_hair_follicle0.93737526
84MP0001661_extended_life_span0.93416891
85MP0009384_cardiac_valve_regurgitation0.92351719
86MP0004185_abnormal_adipocyte_glucose0.92092298
87MP0001784_abnormal_fluid_regulation0.89783209
88MP0002234_abnormal_pharynx_morphology0.89236306
89MP0003567_abnormal_fetal_cardiomyocyte0.88867419
90MP0000566_synostosis0.87468580
91MP0003045_fibrosis0.87285574
92MP0003755_abnormal_palate_morphology0.87170368
93MP0000427_abnormal_hair_cycle0.87094897
94MP0000432_abnormal_head_morphology0.87086738
95MP0005621_abnormal_cell_physiology0.86632422
96MP0002398_abnormal_bone_marrow0.86518801
97MP0000759_abnormal_skeletal_muscle0.86510294
98MP0001873_stomach_inflammation0.85936154
99MP0003941_abnormal_skin_development0.85893421
100MP0002233_abnormal_nose_morphology0.85277689
101MP0002210_abnormal_sex_determination0.85210971
102MP0002269_muscular_atrophy0.84826816
103MP0003861_abnormal_nervous_system0.84312878
104MP0008932_abnormal_embryonic_tissue0.83749072
105MP0009278_abnormal_bone_marrow0.83247432
106MP0010630_abnormal_cardiac_muscle0.82917867
107MP0008770_decreased_survivor_rate0.82452728
108MP0003385_abnormal_body_wall0.82021991
109MP0001849_ear_inflammation0.81569457
110MP0003943_abnormal_hepatobiliary_system0.81506185
111MP0005257_abnormal_intraocular_pressure0.81458483
112MP0002114_abnormal_axial_skeleton0.80680296
113MP0003937_abnormal_limbs/digits/tail_de0.78905620
114MP0000751_myopathy0.78875198
115MP0002060_abnormal_skin_morphology0.78578740
116MP0000627_abnormal_mammary_gland0.77239336
117MP0004264_abnormal_extraembryonic_tissu0.77186806
118MP0000266_abnormal_heart_morphology0.76282322
119MP0002111_abnormal_tail_morphology0.76264164
120MP0000647_abnormal_sebaceous_gland0.75642411
121MP0000749_muscle_degeneration0.74966125
122MP0008569_lethality_at_weaning0.74960848
123MP0005384_cellular_phenotype0.74823533
124MP0000534_abnormal_ureter_morphology0.74389191
125MP0003221_abnormal_cardiomyocyte_apopto0.74262724
126MP0000579_abnormal_nail_morphology0.73627595
127MP0003699_abnormal_female_reproductive0.73478754
128MP0002092_abnormal_eye_morphology0.73369059
129MP0003453_abnormal_keratinocyte_physiol0.73255043
130MP0001929_abnormal_gametogenesis0.72527842
131MP0000003_abnormal_adipose_tissue0.67620959
132MP0002019_abnormal_tumor_incidence0.65492154
133MP0003828_pulmonary_edema0.64378104
134MP0004947_skin_inflammation0.63997179
135MP0001216_abnormal_epidermal_layer0.63798715
136MP0002722_abnormal_immune_system0.63747086
137MP0002081_perinatal_lethality0.63201020
138MP0001293_anophthalmia0.62411758
139MP0005023_abnormal_wound_healing0.62392259

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.93328281
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39418244
3Macroorchidism (HP:0000053)3.37185943
4Chromsome breakage (HP:0040012)3.30310760
5Abnormality of the fingertips (HP:0001211)3.05958152
6Nephroblastoma (Wilms tumor) (HP:0002667)3.01665365
7Short 4th metacarpal (HP:0010044)2.95532875
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95532875
9Embryonal renal neoplasm (HP:0011794)2.81157360
10Abnormality of the calcaneus (HP:0008364)2.75463362
11Long eyelashes (HP:0000527)2.68531777
12Narrow palate (HP:0000189)2.64872675
13Deviation of the thumb (HP:0009603)2.55513391
14Shallow orbits (HP:0000586)2.53313157
15High anterior hairline (HP:0009890)2.52734820
16Increased nuchal translucency (HP:0010880)2.50017017
17Proximal placement of thumb (HP:0009623)2.44028325
18Nemaline bodies (HP:0003798)2.42883007
19Heterotopia (HP:0002282)2.40271377
20Truncal obesity (HP:0001956)2.34204113
21Muscle fiber inclusion bodies (HP:0100299)2.33863216
22Prominent nose (HP:0000448)2.32660843
23Trigonocephaly (HP:0000243)2.29020745
24Deep philtrum (HP:0002002)2.28958947
25Hepatoblastoma (HP:0002884)2.27656327
26Genetic anticipation (HP:0003743)2.27513363
27Increased density of long bones (HP:0006392)2.27208659
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26756963
29Obsessive-compulsive behavior (HP:0000722)2.23814236
30Rectal prolapse (HP:0002035)2.22973119
31Abnormality of the left ventricular outflow tract (HP:0011103)2.18661508
32Subaortic stenosis (HP:0001682)2.18661508
33Calcaneovalgus deformity (HP:0001848)2.18626561
34Selective tooth agenesis (HP:0001592)2.18183735
35Ankyloglossia (HP:0010296)2.18158670
36Transitional cell carcinoma of the bladder (HP:0006740)2.15809754
37Enlarged penis (HP:0000040)2.14130780
38Acute myeloid leukemia (HP:0004808)2.13338819
39Aqueductal stenosis (HP:0002410)2.10247997
40Cortical dysplasia (HP:0002539)2.10185802
41Exercise-induced myalgia (HP:0003738)2.09091330
42Abnormality of the 4th metacarpal (HP:0010012)2.08441125
43Rhabdomyosarcoma (HP:0002859)2.07095579
44Oligodontia (HP:0000677)2.04844604
45Cutis marmorata (HP:0000965)2.04412733
46Subacute progressive viral hepatitis (HP:0006572)2.03944645
47Abnormality of oral frenula (HP:0000190)2.03914915
48Urethral obstruction (HP:0000796)2.03712433
49Aortic aneurysm (HP:0004942)2.01510021
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.01395937
51Dysmetric saccades (HP:0000641)2.01309710
52Facial hemangioma (HP:0000329)1.99904125
53Centrally nucleated skeletal muscle fibers (HP:0003687)1.99137557
54Bladder neoplasm (HP:0009725)1.98570949
55Bladder carcinoma (HP:0002862)1.98570949
56Cafe-au-lait spot (HP:0000957)1.97751535
57Astrocytoma (HP:0009592)1.97044202
58Abnormality of the astrocytes (HP:0100707)1.97044202
59Abnormality of the nasal septum (HP:0000419)1.96505940
60Abnormality of chromosome stability (HP:0003220)1.96446090
61Embryonal neoplasm (HP:0002898)1.96000102
62Absent frontal sinuses (HP:0002688)1.95246918
63Increased number of teeth (HP:0011069)1.94477716
64Capillary hemangiomas (HP:0005306)1.94180502
65Abnormality of the salivary glands (HP:0010286)1.92505260
66Pelvic girdle muscle weakness (HP:0003749)1.91587054
67Exercise-induced muscle cramps (HP:0003710)1.91316822
68Oligodactyly (hands) (HP:0001180)1.91131170
69Abnormality of chromosome segregation (HP:0002916)1.89994786
70Abnormality of the phalanges of the hallux (HP:0010057)1.89647556
71Ectopic kidney (HP:0000086)1.89199536
72Limited elbow extension (HP:0001377)1.88609016
73Shoulder girdle muscle weakness (HP:0003547)1.86981699
74Broad palm (HP:0001169)1.86072211
75Broad thumb (HP:0011304)1.85705381
76T lymphocytopenia (HP:0005403)1.85106395
77Genu recurvatum (HP:0002816)1.84771764
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.84563020
79Deviation of the hallux (HP:0010051)1.84517921
80Dilatation of the ascending aorta (HP:0005111)1.83342435
81Papillary thyroid carcinoma (HP:0002895)1.83292783
82Medulloblastoma (HP:0002885)1.82591430
83Hallux valgus (HP:0001822)1.82383598
84Pointed chin (HP:0000307)1.81985262
85Oligodactyly (HP:0012165)1.81157110
86Deformed tarsal bones (HP:0008119)1.80519165
87Mitral valve prolapse (HP:0001634)1.79621984
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79482782
89Vertebral arch anomaly (HP:0008438)1.78942130
90Skull defect (HP:0001362)1.78621957
91Metaphyseal cupping (HP:0003021)1.77577032
92Hypopigmentation of the fundus (HP:0007894)1.77101847
93Malignant gastrointestinal tract tumors (HP:0006749)1.76750681
94Gastrointestinal carcinoma (HP:0002672)1.76750681
95Right ventricular cardiomyopathy (HP:0011663)1.75610739
96Lip pit (HP:0100267)1.75353645
97Difficulty running (HP:0009046)1.74018130
98Inappropriate behavior (HP:0000719)1.73888060
99Glioma (HP:0009733)1.73857045
100Relative macrocephaly (HP:0004482)1.73747869
101Overlapping toe (HP:0001845)1.72928162
102Abnormality of the labia minora (HP:0012880)1.71645711
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71187708
104Uterine leiomyosarcoma (HP:0002891)1.70871626
105Leiomyosarcoma (HP:0100243)1.70871626
106Smooth philtrum (HP:0000319)1.70621871
107Rimmed vacuoles (HP:0003805)1.70489784
108Syringomyelia (HP:0003396)1.69275693
109Spinal cord lesions (HP:0100561)1.69275693
110Abnormal lung lobation (HP:0002101)1.68649505
111Advanced eruption of teeth (HP:0006288)1.67861604
112Hypoplastic labia majora (HP:0000059)1.67610339
113Missing ribs (HP:0000921)1.67235853
114Osteolytic defects of the hand bones (HP:0009699)1.66693700
115Osteolytic defects of the phalanges of the hand (HP:0009771)1.66693700
116Hypoplasia of the maxilla (HP:0000327)1.66576216
117Rhizomelia (HP:0008905)1.65406434
118Abnormality of T cell number (HP:0011839)1.65378529
119Thick eyebrow (HP:0000574)1.64297766
120Long clavicles (HP:0000890)1.64209942
121Flat acetabular roof (HP:0003180)1.64106753
122Cerebral aneurysm (HP:0004944)1.63749617
123Microglossia (HP:0000171)1.63341636
124Skin tags (HP:0010609)1.62980043
125Basal cell carcinoma (HP:0002671)1.62328186
126Increased connective tissue (HP:0009025)1.61652725
127Papilledema (HP:0001085)1.60698568
128Ependymoma (HP:0002888)1.60456186
129Excessive salivation (HP:0003781)1.60006191
130Drooling (HP:0002307)1.60006191
131Cubitus valgus (HP:0002967)1.59945731
132Exostoses (HP:0100777)1.59701439
133Duodenal stenosis (HP:0100867)1.59639978
134Small intestinal stenosis (HP:0012848)1.59639978
135Impaired smooth pursuit (HP:0007772)1.59634704
136Low anterior hairline (HP:0000294)1.59257280
137Hypospadias (HP:0000047)1.58916855
138Sandal gap (HP:0001852)1.58868217
139Hyperacusis (HP:0010780)1.58778975
140Dislocated radial head (HP:0003083)1.58185329
141Spastic diplegia (HP:0001264)1.57534860
142Abnormality of the preputium (HP:0100587)1.57375698
143Broad phalanges of the hand (HP:0009768)1.57332381
144Attention deficit hyperactivity disorder (HP:0007018)1.56699869
145Atresia of the external auditory canal (HP:0000413)1.56532230
146Bicuspid aortic valve (HP:0001647)1.55874803
147Disproportionate tall stature (HP:0001519)1.55748745
148Broad finger (HP:0001500)1.55685325
149Bowel diverticulosis (HP:0005222)1.55482350
150Abnormality of the right ventricle (HP:0001707)1.55066535
151Abnormality of the hip-girdle musculature (HP:0001445)1.54085678
152Abnormality of the musculature of the pelvis (HP:0001469)1.54085678
153Ventricular fibrillation (HP:0001663)1.53387697
154Blepharitis (HP:0000498)1.51908794
155Ureteral stenosis (HP:0000071)1.51571692
156Persistence of primary teeth (HP:0006335)1.50844761
157Sacral dimple (HP:0000960)1.50579409
158Ankle contracture (HP:0006466)1.49639005
159Colon cancer (HP:0003003)1.49310985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.27305966
2PNCK3.04483848
3EEF2K2.86990543
4LATS12.82597284
5CDC72.79516256
6SMG12.55075164
7MET2.38302112
8NEK22.23058827
9DMPK2.11524320
10MAP3K102.10769392
11FGFR32.05551237
12BUB12.01908918
13PKN21.96513712
14TAF11.95274424
15SCYL21.89589402
16BRD41.69995270
17ALK1.62103089
18CDK61.60395109
19NTRK31.59870157
20ICK1.58859758
21TAOK11.58551847
22CAMK1G1.58265545
23TRIB31.58036972
24MST1R1.57319019
25FGFR11.56199327
26CAMK1D1.54077004
27MKNK11.52868546
28MAP3K71.51126972
29STK101.50135369
30KSR11.42213453
31RPS6KA41.40407797
32MELK1.37459618
33TSSK61.33301806
34NEK11.32453136
35LATS21.27813683
36SRPK11.27523937
37MAP3K91.27082441
38STK31.26908056
39TTN1.23661033
40RIPK11.20472909
41CHEK11.18178029
42SIK21.17853240
43CDK91.16274720
44PLK41.15195406
45MTOR1.14695653
46EIF2AK11.13143912
47PLK31.12809174
48BMX1.12231975
49MAP4K11.08501535
50BRAF1.06894928
51FGFR21.06506614
52FRK1.04478849
53CDK41.03109585
54OBSCN1.02682039
55PTK21.01538895
56KSR20.98830954
57PDGFRB0.97779482
58NEK90.97359290
59CDK190.95874895
60PDGFRA0.94634347
61AURKB0.91541196
62PRKCH0.91332171
63PRPF4B0.90851695
64JAK30.90266234
65MAP3K40.89402101
66FGFR40.89020847
67SGK30.87675571
68YES10.87038751
69MARK20.86900054
70ATM0.86333378
71RET0.84783199
72CHEK20.84564370
73PTK60.81838610
74TTK0.81628570
75ATR0.80760459
76STK240.80313623
77BRSK20.79447618
78CDK20.78863924
79DYRK30.78498138
80STK380.77847036
81STK38L0.77425735
82TNIK0.76600146
83PAK60.75850665
84MAP3K80.73911180
85TXK0.73432190
86RAF10.71445427
87ITK0.71189029
88PASK0.70128118
89BRSK10.67292815
90CSNK1G20.66757836
91MINK10.66706257
92CDK10.64906583
93NLK0.64219193
94CSNK1D0.63947351
95PAK20.62873525
96ERBB30.61987907
97SGK20.61915395
98STK110.61686055
99AKT30.61609539
100LRRK20.60747275
101EPHA30.60467276
102PLK10.60466750
103CSNK1E0.59843474
104WNK10.58736317
105NTRK20.57948019
106MAPK100.57451580
107MAP3K20.55891570
108EIF2AK20.55164511
109SGK10.54276922
110MKNK20.53782086
111CSNK1A1L0.53079288
112RPS6KB20.52018740
113NTRK10.51751749
114MAP3K50.51313403
115MAPK140.51090450
116PRKDC0.50840148
117PBK0.50378090
118CDC42BPA0.50234583
119PDK10.50195635
120CDK30.47150269
121MAPK80.46998843
122TYRO30.46495243
123HCK0.45586921
124CAMKK10.45387284
125MAP3K130.45198547
126HIPK20.44723343
127CHUK0.44686041
128* GSK3B0.44410019
129PRKD30.44206755
130FGR0.43972908
131NUAK10.43532186
132CDK70.42076100
133WEE10.41646482
134JAK20.41343141
135EPHA20.39702504
136RPS6KB10.37686179
137PAK40.32462526
138ERBB40.32384544
139EIF2AK30.32347476

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.70260952
2Mismatch repair_Homo sapiens_hsa034302.15803606
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82494901
4Cell cycle_Homo sapiens_hsa041101.68216499
5Spliceosome_Homo sapiens_hsa030401.62712636
6Chronic myeloid leukemia_Homo sapiens_hsa052201.61075661
7mTOR signaling pathway_Homo sapiens_hsa041501.60885415
8MicroRNAs in cancer_Homo sapiens_hsa052061.58047024
9Base excision repair_Homo sapiens_hsa034101.56772048
10T cell receptor signaling pathway_Homo sapiens_hsa046601.47694488
11Glioma_Homo sapiens_hsa052141.47558745
12Long-term potentiation_Homo sapiens_hsa047201.46573520
13Adherens junction_Homo sapiens_hsa045201.46310597
14Dorso-ventral axis formation_Homo sapiens_hsa043201.40584681
15Pancreatic cancer_Homo sapiens_hsa052121.39746353
16Endometrial cancer_Homo sapiens_hsa052131.39573768
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39153019
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37557589
19Colorectal cancer_Homo sapiens_hsa052101.37536901
20Non-small cell lung cancer_Homo sapiens_hsa052231.33482751
21Nucleotide excision repair_Homo sapiens_hsa034201.31068701
22* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28943207
23Oocyte meiosis_Homo sapiens_hsa041141.28763556
24mRNA surveillance pathway_Homo sapiens_hsa030151.28702911
25Biosynthesis of amino acids_Homo sapiens_hsa012301.25946020
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25695116
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25443195
28Pentose phosphate pathway_Homo sapiens_hsa000301.20919738
29RNA transport_Homo sapiens_hsa030131.20860344
30Small cell lung cancer_Homo sapiens_hsa052221.20514470
31HTLV-I infection_Homo sapiens_hsa051661.18867381
32Proteoglycans in cancer_Homo sapiens_hsa052051.16594171
33Homologous recombination_Homo sapiens_hsa034401.14737576
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.11771314
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11053194
36Insulin signaling pathway_Homo sapiens_hsa049101.10405081
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10128686
38Prostate cancer_Homo sapiens_hsa052151.08165434
39Renal cell carcinoma_Homo sapiens_hsa052111.07378054
40Thyroid cancer_Homo sapiens_hsa052161.06929089
41p53 signaling pathway_Homo sapiens_hsa041151.06538631
42Viral myocarditis_Homo sapiens_hsa054161.06528348
43ErbB signaling pathway_Homo sapiens_hsa040121.04968248
44Hepatitis B_Homo sapiens_hsa051611.04459867
45Fanconi anemia pathway_Homo sapiens_hsa034601.04310476
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.03869324
47Lysine degradation_Homo sapiens_hsa003101.03473631
48FoxO signaling pathway_Homo sapiens_hsa040681.02810081
49Hippo signaling pathway_Homo sapiens_hsa043901.01578667
50Viral carcinogenesis_Homo sapiens_hsa052030.99337081
51Tight junction_Homo sapiens_hsa045300.98107506
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97493913
53One carbon pool by folate_Homo sapiens_hsa006700.97370418
54Primary immunodeficiency_Homo sapiens_hsa053400.96809144
55Type II diabetes mellitus_Homo sapiens_hsa049300.95648315
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.93517597
57B cell receptor signaling pathway_Homo sapiens_hsa046620.93501817
58VEGF signaling pathway_Homo sapiens_hsa043700.93266607
59Prolactin signaling pathway_Homo sapiens_hsa049170.92969636
60Wnt signaling pathway_Homo sapiens_hsa043100.92925424
61Choline metabolism in cancer_Homo sapiens_hsa052310.92771519
62Estrogen signaling pathway_Homo sapiens_hsa049150.92189579
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92128169
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92072906
65TGF-beta signaling pathway_Homo sapiens_hsa043500.91617394
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91510308
67Oxytocin signaling pathway_Homo sapiens_hsa049210.91106465
68Circadian rhythm_Homo sapiens_hsa047100.90431389
69Acute myeloid leukemia_Homo sapiens_hsa052210.90306248
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90266063
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90050271
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88777075
73Focal adhesion_Homo sapiens_hsa045100.88402734
74RNA degradation_Homo sapiens_hsa030180.87667954
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87154872
76MAPK signaling pathway_Homo sapiens_hsa040100.86759924
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86352648
78GnRH signaling pathway_Homo sapiens_hsa049120.86244376
79Carbon metabolism_Homo sapiens_hsa012000.86207843
80Basal cell carcinoma_Homo sapiens_hsa052170.85281298
81Dopaminergic synapse_Homo sapiens_hsa047280.85009679
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84848330
83Circadian entrainment_Homo sapiens_hsa047130.84594180
84AMPK signaling pathway_Homo sapiens_hsa041520.83875750
85Amphetamine addiction_Homo sapiens_hsa050310.83700277
86Non-homologous end-joining_Homo sapiens_hsa034500.83686964
87Glucagon signaling pathway_Homo sapiens_hsa049220.81367057
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80921379
89Selenocompound metabolism_Homo sapiens_hsa004500.80033430
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78380910
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77641529
92Bladder cancer_Homo sapiens_hsa052190.77392317
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76805610
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76686632
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76591714
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76331621
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75514042
98Cholinergic synapse_Homo sapiens_hsa047250.75362988
99Melanogenesis_Homo sapiens_hsa049160.74226908
100Gastric acid secretion_Homo sapiens_hsa049710.73810696
101Platelet activation_Homo sapiens_hsa046110.73013117
102Osteoclast differentiation_Homo sapiens_hsa043800.72541195
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72040063
104Rap1 signaling pathway_Homo sapiens_hsa040150.71334092
105Pathways in cancer_Homo sapiens_hsa052000.70838965
106cAMP signaling pathway_Homo sapiens_hsa040240.70428163
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70378929
108Glutamatergic synapse_Homo sapiens_hsa047240.69556824
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.69483968
110Axon guidance_Homo sapiens_hsa043600.69104994
111Dilated cardiomyopathy_Homo sapiens_hsa054140.68792594
112HIF-1 signaling pathway_Homo sapiens_hsa040660.68064543
113Notch signaling pathway_Homo sapiens_hsa043300.66836950
114Nicotine addiction_Homo sapiens_hsa050330.66789908
115Inositol phosphate metabolism_Homo sapiens_hsa005620.66145426
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.65925402
117Herpes simplex infection_Homo sapiens_hsa051680.65814469
118Long-term depression_Homo sapiens_hsa047300.64362352
119Chemokine signaling pathway_Homo sapiens_hsa040620.64197032
120Basal transcription factors_Homo sapiens_hsa030220.63879625
121Melanoma_Homo sapiens_hsa052180.63616589
122Type I diabetes mellitus_Homo sapiens_hsa049400.63473613
123Hedgehog signaling pathway_Homo sapiens_hsa043400.63161744
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.62953364
125Toxoplasmosis_Homo sapiens_hsa051450.62886945
126Insulin resistance_Homo sapiens_hsa049310.62762287
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62714249
128Pyruvate metabolism_Homo sapiens_hsa006200.60361949
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59396651
130Amoebiasis_Homo sapiens_hsa051460.56969236
131ECM-receptor interaction_Homo sapiens_hsa045120.50963429
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48231058
133Gap junction_Homo sapiens_hsa045400.40897180
134Apoptosis_Homo sapiens_hsa042100.40258339
135Epstein-Barr virus infection_Homo sapiens_hsa051690.40236738
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39995477
137Shigellosis_Homo sapiens_hsa051310.39203222

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