MED13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)5.14705828
2mitotic sister chromatid cohesion (GO:0007064)4.96031630
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.32882071
4regulation of RNA export from nucleus (GO:0046831)4.23317060
5nuclear pore complex assembly (GO:0051292)3.88800108
6regulation of nucleobase-containing compound transport (GO:0032239)3.71779930
7regulation of centriole replication (GO:0046599)3.55155304
8histone H3-K4 trimethylation (GO:0080182)3.53619956
9regulation of histone H3-K27 methylation (GO:0061085)3.52006437
10histone H3-K36 demethylation (GO:0070544)3.47706205
11embryonic process involved in female pregnancy (GO:0060136)3.47674564
12positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.45158913
13regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.45158913
14regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.31784376
15positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.31784376
16corticosteroid receptor signaling pathway (GO:0031958)3.31681550
17glucocorticoid receptor signaling pathway (GO:0042921)3.30373986
18embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29943278
19NLS-bearing protein import into nucleus (GO:0006607)3.25078677
20regulation of NFAT protein import into nucleus (GO:0051532)3.23363027
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19726942
22negative regulation of neurotransmitter secretion (GO:0046929)3.17349358
23histone H3-K9 demethylation (GO:0033169)3.17347009
24regulation of transforming growth factor beta2 production (GO:0032909)3.14737450
25nuclear pore organization (GO:0006999)3.13837498
26histone H3-K4 methylation (GO:0051568)3.09505207
27growth hormone receptor signaling pathway (GO:0060396)3.05447338
28positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.03867134
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.03256454
30regulation of translation, ncRNA-mediated (GO:0045974)3.03256454
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03256454
32protein K48-linked deubiquitination (GO:0071108)2.99467090
33histone lysine demethylation (GO:0070076)2.98301451
34embryonic eye morphogenesis (GO:0048048)2.94702352
35striated muscle atrophy (GO:0014891)2.94619305
36cellular response to ethanol (GO:0071361)2.94602689
37positive regulation of mRNA catabolic process (GO:0061014)2.90809312
38regulation of establishment or maintenance of cell polarity (GO:0032878)2.90022520
39intestinal epithelial cell development (GO:0060576)2.89273750
40peptidyl-lysine trimethylation (GO:0018023)2.88891102
41negative regulation of histone methylation (GO:0031061)2.88692305
42pore complex assembly (GO:0046931)2.88132341
43insulin-like growth factor receptor signaling pathway (GO:0048009)2.84925691
44dosage compensation (GO:0007549)2.83645077
45pre-miRNA processing (GO:0031054)2.83397889
46skeletal muscle adaptation (GO:0043501)2.81562107
47positive regulation of histone deacetylation (GO:0031065)2.80942115
48regulation of DNA endoreduplication (GO:0032875)2.78972094
49positive regulation of keratinocyte differentiation (GO:0045618)2.77342517
50histone demethylation (GO:0016577)2.77127875
51monoubiquitinated protein deubiquitination (GO:0035520)2.75018711
52peptidyl-lysine dimethylation (GO:0018027)2.73382957
53interkinetic nuclear migration (GO:0022027)2.73075794
54regulation of mRNA catabolic process (GO:0061013)2.73044559
55Golgi to endosome transport (GO:0006895)2.72581596
56oocyte development (GO:0048599)2.72436434
57mitotic chromosome condensation (GO:0007076)2.70408036
58hippo signaling (GO:0035329)2.69438292
59peptidyl-threonine dephosphorylation (GO:0035970)2.66102067
60TOR signaling (GO:0031929)2.64974862
61regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64759464
62nucleus organization (GO:0006997)2.64743745
63regulation of pigment cell differentiation (GO:0050932)2.62854143
64positive regulation of mitotic sister chromatid separation (GO:1901970)2.62020673
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62020673
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62020673
67regulation of protein polyubiquitination (GO:1902914)2.61416353
68phospholipid translocation (GO:0045332)2.60712632
69lipid translocation (GO:0034204)2.60712632
70cellular response to growth hormone stimulus (GO:0071378)2.60022115
71regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.59288591
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58807069
73muscle atrophy (GO:0014889)2.58257031
74histone lysine methylation (GO:0034968)2.56804188
75negative regulation of B cell proliferation (GO:0030889)2.56670785
76trophectodermal cell differentiation (GO:0001829)2.55452982
77embryonic camera-type eye morphogenesis (GO:0048596)2.55177102
78positive regulation of gamma-delta T cell activation (GO:0046645)2.54261563
79N-terminal protein amino acid acetylation (GO:0006474)2.51410479
80regulation of histone H3-K9 methylation (GO:0051570)2.49396489
81peptidyl-threonine phosphorylation (GO:0018107)2.48895037
82iron ion import (GO:0097286)2.48110364
83positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.46963611
84positive regulation of protein import into nucleus, translocation (GO:0033160)2.46549135
85early endosome to late endosome transport (GO:0045022)2.46229135
86peptidyl-threonine modification (GO:0018210)2.45768883
87stress granule assembly (GO:0034063)2.44269864
88protein demethylation (GO:0006482)2.43525657
89protein dealkylation (GO:0008214)2.43525657
90COPII vesicle coating (GO:0048208)2.42908494
91hypotonic response (GO:0006971)2.41465223
92regulation of centrosome duplication (GO:0010824)2.40854312
93labyrinthine layer development (GO:0060711)2.40341055
94chondrocyte development (GO:0002063)2.38626052
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.37524704
96histone H3-K9 methylation (GO:0051567)2.36452270
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.32946437
98positive regulation of cellular response to insulin stimulus (GO:1900078)2.30806455
99nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.29160132
100histone mRNA catabolic process (GO:0071044)2.28690830
101I-kappaB phosphorylation (GO:0007252)2.28387733
102histone H3-K9 modification (GO:0061647)2.28058347
103positive regulation of insulin receptor signaling pathway (GO:0046628)2.25580429
104regulation of histone deacetylation (GO:0031063)2.24056757
105mammary gland epithelial cell proliferation (GO:0033598)2.24053129
106protein K11-linked deubiquitination (GO:0035871)2.23819914
107phosphatidylinositol phosphorylation (GO:0046854)2.23356765
108negative regulation of DNA repair (GO:0045738)2.23224295
109regulation of sister chromatid cohesion (GO:0007063)2.23042768
110pericardium development (GO:0060039)2.21565213
111heart morphogenesis (GO:0003007)2.20749661
112regulation of mRNA 3-end processing (GO:0031440)2.20451661
113nerve growth factor signaling pathway (GO:0038180)2.19934618
114positive regulation of mRNA 3-end processing (GO:0031442)2.19235199
115protein targeting to Golgi (GO:0000042)2.19232056
116B cell homeostasis (GO:0001782)2.19115294
117morphogenesis of an epithelial sheet (GO:0002011)2.18180823
118radial glial cell differentiation (GO:0060019)2.17779316
119hepatocyte apoptotic process (GO:0097284)2.17143843
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.16924904
121negative regulation of cell killing (GO:0031342)2.16924904
122regulation of alkaline phosphatase activity (GO:0010692)2.15841145
123establishment of protein localization to Golgi (GO:0072600)2.15416694
124Golgi organization (GO:0007030)2.14733519
125regulation of keratinocyte differentiation (GO:0045616)2.13594481
126sister chromatid cohesion (GO:0007062)2.13412772
127dorsal/ventral axis specification (GO:0009950)2.13226976
128embryonic hemopoiesis (GO:0035162)2.11626811
129protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.10263235
130regulation of protein deacetylation (GO:0090311)2.09564147
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.09079279
132peptidyl-lysine methylation (GO:0018022)2.08398080
133positive regulation of DNA-templated transcription, initiation (GO:2000144)2.07774850
134face morphogenesis (GO:0060325)2.07248563
135JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.06705840
136genitalia morphogenesis (GO:0035112)2.06204881
137nucleus localization (GO:0051647)2.06164412
138embryonic viscerocranium morphogenesis (GO:0048703)2.05898108
139positive T cell selection (GO:0043368)2.05863818
140definitive hemopoiesis (GO:0060216)2.05855916
141RNA stabilization (GO:0043489)2.05373536
142mRNA stabilization (GO:0048255)2.05373536
143germ cell migration (GO:0008354)2.04395369
144regulation of histone methylation (GO:0031060)2.04345372
145branching involved in prostate gland morphogenesis (GO:0060442)2.03212780
146regulation of gamma-delta T cell differentiation (GO:0045586)2.03203549
147regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.02841824
148coronary vasculature morphogenesis (GO:0060977)2.01824632
149regulation of establishment of cell polarity (GO:2000114)2.01394034
150positive thymic T cell selection (GO:0045059)2.01285081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.45401741
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.66293185
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41882078
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28331836
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17754386
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.99875143
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.70148152
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.62099521
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59179236
10E2F7_22180533_ChIP-Seq_HELA_Human2.32174681
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.17664769
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14341077
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97947646
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90377979
15RUNX_20019798_ChIP-Seq_JUKART_Human1.85920564
16TP53_16413492_ChIP-PET_HCT116_Human1.76291609
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70783220
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70182950
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66791620
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.65864651
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62092816
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.61546378
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61200553
24* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59304786
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.56311424
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55200776
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.54804177
28AR_21909140_ChIP-Seq_LNCAP_Human1.53914306
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52042990
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.51029151
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50097484
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49338368
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48584620
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.47900239
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47527509
36ER_23166858_ChIP-Seq_MCF-7_Human1.47464066
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.45787414
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44775621
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44022487
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43096742
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40764165
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40697298
43TCF7_22412390_ChIP-Seq_EML_Mouse1.39118063
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35405883
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32904158
46BRD4_25478319_ChIP-Seq_HGPS_Human1.32505491
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32391187
48GATA1_22025678_ChIP-Seq_K562_Human1.32244713
49AHR_22903824_ChIP-Seq_MCF-7_Human1.31476961
50MYC_22102868_ChIP-Seq_BL_Human1.31467270
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31375422
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27949403
53* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27127718
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26549940
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24511203
56VDR_24787735_ChIP-Seq_THP-1_Human1.24482055
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24288367
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.23257776
59AR_21572438_ChIP-Seq_LNCaP_Human1.22967946
60* IRF8_27001747_Chip-Seq_BMDM_Mouse1.21542996
61* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21104624
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18654322
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.17578101
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16646524
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16474633
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15206391
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14735891
68* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14147108
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13266770
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11909066
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.11312200
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11044766
73MYB_26560356_Chip-Seq_TH2_Human1.10813679
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09888138
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09577464
76* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09355018
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.08620188
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.08204106
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.08047732
80RXR_22108803_ChIP-Seq_LS180_Human1.07846827
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06535628
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06535628
83* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05525216
84* STAT3_23295773_ChIP-Seq_U87_Human1.04853043
85KDM2B_26808549_Chip-Seq_DND41_Human1.04780553
86TP63_23658742_ChIP-Seq_EP156T_Human1.03363883
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.02911189
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02504581
89MYB_26560356_Chip-Seq_TH1_Human1.02477401
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02471083
91SCL_19346495_ChIP-Seq_HPC-7_Human1.02204330
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02106366
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.01854886
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01525288
95CJUN_26792858_Chip-Seq_BT549_Human1.00380581
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00369154
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00224854
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98902400
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98304164
100* GATA6_25053715_ChIP-Seq_YYC3_Human0.97578402
101EP300_21415370_ChIP-Seq_HL-1_Mouse0.97462920
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97447532
103* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97061695
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.96938564
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96160258
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95326585
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95326585
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95294003
109* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95107949
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94436415
111CHD1_26751641_Chip-Seq_LNCaP_Human0.93925020
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93473304
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93351860
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92484313
115FUS_26573619_Chip-Seq_HEK293_Human0.92390158
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92162941
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91900213
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91144341
119PU_27001747_Chip-Seq_BMDM_Mouse0.90688354
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90662266
121* SMAD4_21799915_ChIP-Seq_A2780_Human0.90498774
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.90398476
123* TCF4_23295773_ChIP-Seq_U87_Human0.89641621
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89256542
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88782351
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88782351
127EWS_26573619_Chip-Seq_HEK293_Human0.88743161
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87986301
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87783237
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85995840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.90839473
2MP0005076_abnormal_cell_differentiation3.34165576
3MP0003300_gastrointestinal_ulcer3.28017927
4MP0010352_gastrointestinal_tract_polyps2.67239945
5MP0002166_altered_tumor_susceptibility2.58125237
6MP0002009_preneoplasia2.52199713
7MP0003787_abnormal_imprinting2.25652599
8MP0008057_abnormal_DNA_replication2.09038616
9MP0010234_abnormal_vibrissa_follicle2.07091645
10MP0003303_peritoneal_inflammation2.05388074
11MP0010307_abnormal_tumor_latency2.05345343
12MP0002006_tumorigenesis2.05252583
13MP0004233_abnormal_muscle_weight1.98231235
14MP0003705_abnormal_hypodermis_morpholog1.98139030
15MP0004808_abnormal_hematopoietic_stem1.97251521
16MP0003045_fibrosis1.95124877
17MP0000733_abnormal_muscle_development1.93263337
18MP0010678_abnormal_skin_adnexa1.89463811
19MP0006054_spinal_hemorrhage1.87354292
20MP0005451_abnormal_body_composition1.82814998
21MP0000383_abnormal_hair_follicle1.79673493
22MP0003091_abnormal_cell_migration1.71348677
23MP0002877_abnormal_melanocyte_morpholog1.67619981
24MP0001299_abnormal_eye_distance/1.67538028
25MP0002796_impaired_skin_barrier1.62119653
26MP0003656_abnormal_erythrocyte_physiolo1.56470187
27MP0003941_abnormal_skin_development1.55441187
28MP0005248_abnormal_Harderian_gland1.51362521
29MP0002396_abnormal_hematopoietic_system1.43991402
30MP0003121_genomic_imprinting1.41125231
31MP0009115_abnormal_fat_cell1.40634579
32MP0005666_abnormal_adipose_tissue1.40461406
33MP0009703_decreased_birth_body1.34376917
34MP0009697_abnormal_copulation1.33803303
35MP0003890_abnormal_embryonic-extraembry1.33401000
36MP0003950_abnormal_plasma_membrane1.32927652
37MP0001800_abnormal_humoral_immune1.32426745
38MP0003566_abnormal_cell_adhesion1.31676367
39MP0003935_abnormal_craniofacial_develop1.30061020
40MP0000428_abnormal_craniofacial_morphol1.29834071
41MP0001879_abnormal_lymphatic_vessel1.29656183
42MP0001790_abnormal_immune_system1.29489978
43MP0005387_immune_system_phenotype1.29489978
44MP0003077_abnormal_cell_cycle1.29143915
45MP0002098_abnormal_vibrissa_morphology1.26969677
46MP0004264_abnormal_extraembryonic_tissu1.23197938
47MP0001293_anophthalmia1.22661860
48MP0005187_abnormal_penis_morphology1.21551368
49MP0000427_abnormal_hair_cycle1.19391065
50MP0001915_intracranial_hemorrhage1.18932477
51MP0002925_abnormal_cardiovascular_devel1.17120304
52MP0003221_abnormal_cardiomyocyte_apopto1.16317451
53MP0005503_abnormal_tendon_morphology1.16161085
54MP0004381_abnormal_hair_follicle1.15717951
55MP0009780_abnormal_chondrocyte_physiolo1.13652503
56MP0000432_abnormal_head_morphology1.13526194
57MP0009278_abnormal_bone_marrow1.13142704
58MP0005367_renal/urinary_system_phenotyp1.09791309
59MP0000516_abnormal_urinary_system1.09791309
60MP0009384_cardiac_valve_regurgitation1.09632811
61MP0004947_skin_inflammation1.09371176
62MP0002332_abnormal_exercise_endurance1.08729140
63MP0000703_abnormal_thymus_morphology1.08458967
64MP0003191_abnormal_cellular_cholesterol1.07887215
65MP0003937_abnormal_limbs/digits/tail_de1.07707466
66MP0004197_abnormal_fetal_growth/weight/1.07164963
67MP0003868_abnormal_feces_composition1.06976388
68MP0009053_abnormal_anal_canal1.06827701
69MP0002092_abnormal_eye_morphology1.06586588
70MP0005375_adipose_tissue_phenotype1.04264675
71MP0003763_abnormal_thymus_physiology1.04069134
72MP0004185_abnormal_adipocyte_glucose1.03578950
73MP0002452_abnormal_antigen_presenting1.03073321
74MP0002398_abnormal_bone_marrow1.02405600
75MP0005621_abnormal_cell_physiology1.01978912
76MP0001849_ear_inflammation1.01925040
77MP0001730_embryonic_growth_arrest1.01794369
78MP0003385_abnormal_body_wall1.00850107
79MP0002928_abnormal_bile_duct1.00706643
80MP0002086_abnormal_extraembryonic_tissu1.00536389
81MP0001697_abnormal_embryo_size1.00024691
82MP0002088_abnormal_embryonic_growth/wei0.99711864
83MP0001216_abnormal_epidermal_layer0.99613398
84MP0001835_abnormal_antigen_presentation0.98074754
85MP0003984_embryonic_growth_retardation0.98058659
86MP0000767_abnormal_smooth_muscle0.97570460
87MP0003943_abnormal_hepatobiliary_system0.97113072
88MP0000537_abnormal_urethra_morphology0.95546520
89MP0010368_abnormal_lymphatic_system0.94164384
90MP0008961_abnormal_basal_metabolism0.93871274
91MP0003183_abnormal_peptide_metabolism0.92223419
92MP0003755_abnormal_palate_morphology0.91220247
93MP0002168_other_aberrant_phenotype0.89085911
94MP0004957_abnormal_blastocyst_morpholog0.88776967
95MP0002998_abnormal_bone_remodeling0.87990469
96MP0000627_abnormal_mammary_gland0.87831070
97MP0002084_abnormal_developmental_patter0.87111586
98MP0002896_abnormal_bone_mineralization0.86818412
99MP0000377_abnormal_hair_follicle0.86245840
100MP0003115_abnormal_respiratory_system0.84725515
101MP0005501_abnormal_skin_physiology0.84670352
102MP0010094_abnormal_chromosome_stability0.83538171
103MP0001672_abnormal_embryogenesis/_devel0.83119653
104MP0005380_embryogenesis_phenotype0.83119653
105MP0000350_abnormal_cell_proliferation0.82825960
106MP0009672_abnormal_birth_weight0.81062871
107MP0002420_abnormal_adaptive_immunity0.79988831
108MP0008004_abnormal_stomach_pH0.79834661
109MP0002697_abnormal_eye_size0.79376479
110MP0000371_diluted_coat_color0.79352273
111MP0005257_abnormal_intraocular_pressure0.79148217
112MP0003453_abnormal_keratinocyte_physiol0.78873964
113MP0001819_abnormal_immune_cell0.78572762
114MP0003828_pulmonary_edema0.78544533
115MP0000716_abnormal_immune_system0.78407295
116MP0002109_abnormal_limb_morphology0.78047466
117MP0000003_abnormal_adipose_tissue0.77807557
118MP0010630_abnormal_cardiac_muscle0.77588320
119MP0005023_abnormal_wound_healing0.76859747
120MP0005409_darkened_coat_color0.76359092
121MP0005174_abnormal_tail_pigmentation0.76354407
122MP0001873_stomach_inflammation0.75472570
123MP0005671_abnormal_response_to0.75301536
124MP0003632_abnormal_nervous_system0.74894582
125MP0002723_abnormal_immune_serum0.74534183
126MP0003448_altered_tumor_morphology0.74013391
127MP0001851_eye_inflammation0.73726727
128MP0003111_abnormal_nucleus_morphology0.72183048
129MP0002080_prenatal_lethality0.69417257
130MP0005408_hypopigmentation0.68414743
131MP0006138_congestive_heart_failure0.68100169
132MP0002060_abnormal_skin_morphology0.67506218
133MP0002269_muscular_atrophy0.66803597
134MP0003699_abnormal_female_reproductive0.66125777
135MP0002085_abnormal_embryonic_tissue0.66036610
136MP0005384_cellular_phenotype0.65882594
137MP0001191_abnormal_skin_condition0.65089940
138MP0002108_abnormal_muscle_morphology0.64596543
139MP0004130_abnormal_muscle_cell0.63557962

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.44340390
2Volvulus (HP:0002580)3.77955942
3Macroorchidism (HP:0000053)3.62113190
4Short 4th metacarpal (HP:0010044)3.53104664
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53104664
6Thyroid carcinoma (HP:0002890)3.47613712
7Narrow palate (HP:0000189)3.08305312
8Curly hair (HP:0002212)3.00879323
9Abnormality of the nasal septum (HP:0000419)2.88045687
10Long eyelashes (HP:0000527)2.77756296
11Chromsome breakage (HP:0040012)2.77372273
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77262953
13Dysmetric saccades (HP:0000641)2.62281159
14Aqueductal stenosis (HP:0002410)2.59591774
15Trigonocephaly (HP:0000243)2.56561927
16Menstrual irregularities (HP:0000858)2.52331732
17Sandal gap (HP:0001852)2.48984028
18Germ cell neoplasia (HP:0100728)2.48359483
19Absent frontal sinuses (HP:0002688)2.48205769
20Midline defect of the nose (HP:0004122)2.47595279
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46820029
22Nephroblastoma (Wilms tumor) (HP:0002667)2.46706380
23Neonatal hypoglycemia (HP:0001998)2.46662570
24Micronodular cirrhosis (HP:0001413)2.45878059
25Subacute progressive viral hepatitis (HP:0006572)2.42542867
26Abnormality of the 4th metacarpal (HP:0010012)2.42525632
27Overgrowth (HP:0001548)2.41573394
28Hematochezia (HP:0002573)2.41081992
29Aortic aneurysm (HP:0004942)2.38829264
30Papillary thyroid carcinoma (HP:0002895)2.38579815
31Limited elbow extension (HP:0001377)2.32391347
32Spinal cord lesions (HP:0100561)2.31141307
33Syringomyelia (HP:0003396)2.31141307
34Termporal pattern (HP:0011008)2.30943165
35Insidious onset (HP:0003587)2.30943165
36Heterotopia (HP:0002282)2.29259557
37Embryonal renal neoplasm (HP:0011794)2.29119622
38Shallow orbits (HP:0000586)2.28191505
39Flat acetabular roof (HP:0003180)2.26501072
40Lip pit (HP:0100267)2.24150236
41Cubitus valgus (HP:0002967)2.22710029
42Truncal obesity (HP:0001956)2.20510775
43Cystic hygroma (HP:0000476)2.20152474
44Thyroiditis (HP:0100646)2.16616997
45Deep philtrum (HP:0002002)2.13517214
46Acute myeloid leukemia (HP:0004808)2.12549566
47Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.11468350
48Transitional cell carcinoma of the bladder (HP:0006740)2.11135181
49Hypoplastic labia majora (HP:0000059)2.09229583
50Subaortic stenosis (HP:0001682)2.08454553
51Abnormality of the left ventricular outflow tract (HP:0011103)2.08454553
52Urethral obstruction (HP:0000796)2.07928323
53Relative macrocephaly (HP:0004482)2.00499468
54Thick eyebrow (HP:0000574)1.99642154
55Hypoplasia of the maxilla (HP:0000327)1.99585936
56Coarse hair (HP:0002208)1.97322598
57Obsessive-compulsive behavior (HP:0000722)1.97022570
58Renal cell carcinoma (HP:0005584)1.94759914
59Broad thumb (HP:0011304)1.92940359
60Neoplasm of the adrenal cortex (HP:0100641)1.91826003
61Bladder carcinoma (HP:0002862)1.91205697
62Bladder neoplasm (HP:0009725)1.91205697
63Septate vagina (HP:0001153)1.91194583
64Supernumerary ribs (HP:0005815)1.87558401
65Right ventricular cardiomyopathy (HP:0011663)1.87121380
66Prominent nose (HP:0000448)1.86569560
67Hyperkalemia (HP:0002153)1.86384304
68Fair hair (HP:0002286)1.85988215
69Spondylolisthesis (HP:0003302)1.85674960
70Hypoplastic ischia (HP:0003175)1.85437511
71Esophageal varix (HP:0002040)1.85079652
72Abnormality of the labia majora (HP:0012881)1.83832544
73Oligodontia (HP:0000677)1.83814735
74Dislocated radial head (HP:0003083)1.83460760
75Medulloblastoma (HP:0002885)1.83325149
76Neoplasm of the thyroid gland (HP:0100031)1.81738115
77Microglossia (HP:0000171)1.81314247
78Recurrent viral infections (HP:0004429)1.81281283
79Exostoses (HP:0100777)1.81141732
80Mitral valve prolapse (HP:0001634)1.80893552
81Abnormality of the sella turcica (HP:0002679)1.80854705
82Rhabdomyosarcoma (HP:0002859)1.80826510
83Ankyloglossia (HP:0010296)1.80603978
84Deformed sella turcica (HP:0002681)1.80532051
85Chorioretinal atrophy (HP:0000533)1.79902726
86Genetic anticipation (HP:0003743)1.79496761
87Abnormality of the parietal bone (HP:0002696)1.79317902
88Cerebral aneurysm (HP:0004944)1.78893293
89Sparse lateral eyebrow (HP:0005338)1.78291525
90Broad face (HP:0000283)1.77644016
91Vertebral arch anomaly (HP:0008438)1.77333973
92Widely spaced teeth (HP:0000687)1.76253218
93Low anterior hairline (HP:0000294)1.75565386
94Vitreoretinal degeneration (HP:0000655)1.75507576
95Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75106058
96Cutis marmorata (HP:0000965)1.74882746
97Increased nuchal translucency (HP:0010880)1.74564225
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74507449
99Asymmetry of the thorax (HP:0001555)1.74272504
100Cranial hyperostosis (HP:0004437)1.73758383
101Smooth philtrum (HP:0000319)1.73624978
102Hypopigmentation of the fundus (HP:0007894)1.73404706
103Dental malocclusion (HP:0000689)1.71751154
104Anal stenosis (HP:0002025)1.70849628
105Abnormality of the radial head (HP:0003995)1.70761146
106Abnormality of the frontal sinuses (HP:0002687)1.70334508
107Increased density of long bones (HP:0006392)1.68530372
108Cafe-au-lait spot (HP:0000957)1.67728986
109Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67569768
110Hamartoma (HP:0010566)1.67409308
111Abnormal foot bone ossification (HP:0010675)1.66909137
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66672235
113Abnormality of chromosome stability (HP:0003220)1.66413492
114Abnormality of the epiphyses of the hand (HP:0005924)1.65761160
115Depressed nasal tip (HP:0000437)1.65535495
116Osteolytic defects of the hand bones (HP:0009699)1.64956036
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.64956036
118Increased number of teeth (HP:0011069)1.64895410
119Rectal prolapse (HP:0002035)1.64328751
120Enlarged penis (HP:0000040)1.64218617
121Persistence of primary teeth (HP:0006335)1.63725138
122Periodontitis (HP:0000704)1.63320741
123Leiomyosarcoma (HP:0100243)1.63236172
124Uterine leiomyosarcoma (HP:0002891)1.63236172
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.63009362
126Abnormality of chromosome segregation (HP:0002916)1.62508385
127Breast carcinoma (HP:0003002)1.62180307
128Malignant gastrointestinal tract tumors (HP:0006749)1.61771169
129Gastrointestinal carcinoma (HP:0002672)1.61771169
130Advanced eruption of teeth (HP:0006288)1.61748998
131Agammaglobulinemia (HP:0004432)1.61716687
132Short chin (HP:0000331)1.61281268
133Abnormality of the phalanges of the hallux (HP:0010057)1.60920638
134Ectopic kidney (HP:0000086)1.60673493
135Renovascular hypertension (HP:0100817)1.60602348
136Arterial tortuosity (HP:0005116)1.60160230
137Abnormality of the ischium (HP:0003174)1.59754900
138Thickened calvaria (HP:0002684)1.59278198
139Generalized hypopigmentation of hair (HP:0011358)1.58625611
140Tapered finger (HP:0001182)1.56277249
141Gastrointestinal stroma tumor (HP:0100723)1.56036301
142T lymphocytopenia (HP:0005403)1.55695815
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54150167
144Synophrys (HP:0000664)1.54124564
145Viral hepatitis (HP:0006562)1.52074399
146Cellulitis (HP:0100658)1.51579339
147Cortical dysplasia (HP:0002539)1.50046878
148Ureteral obstruction (HP:0006000)1.49617229
149Deviation of the thumb (HP:0009603)1.48889935
150Large earlobe (HP:0009748)1.48291081
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.47198799
152Abnormality of T cell number (HP:0011839)1.46372088
153Abnormality of incisor morphology (HP:0011063)1.45916482
154Autoimmune thrombocytopenia (HP:0001973)1.45657954
155Lymphopenia (HP:0001888)1.45525376
156Supernumerary bones of the axial skeleton (HP:0009144)1.45477753
157Hepatoblastoma (HP:0002884)1.44908583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.22645910
2CDK123.82127897
3SCYL23.72398448
4AKT32.86045432
5MAP3K102.84725316
6CAMK1D2.70479261
7CAMK1G2.66680396
8FRK2.59436698
9FGFR22.31427745
10FGFR32.31296885
11STK32.11889716
12NEK62.08074180
13NUAK12.01129548
14EPHA32.00803544
15STK101.85572088
16BRD41.83957744
17MST1R1.82864847
18ICK1.69398495
19CDK61.63569262
20RPS6KB21.59684089
21DMPK1.55396326
22PDGFRB1.51529539
23SGK31.47867620
24RIPK11.46406652
25WNK11.46162744
26JAK11.45567175
27CDK91.45538187
28BMPR21.31514378
29SIK11.30628786
30PTK61.30143367
31TAOK31.27092395
32PDGFRA1.24227914
33SGK21.22221299
34PKN21.21440379
35MELK1.15023370
36KSR11.13935785
37MTOR1.12545559
38CHUK1.10302627
39EPHB11.10259686
40YES11.10043705
41PNCK1.10016996
42INSRR1.08868610
43MAP4K11.08354512
44MAP3K141.08099811
45JAK31.07898510
46LATS21.07724206
47PRPF4B1.07635686
48MET1.06084656
49CDC71.05119909
50HIPK21.03264857
51KSR20.99439269
52RPS6KA40.98939658
53STK38L0.98500955
54MAP3K90.96587501
55EEF2K0.93075740
56EIF2AK30.91586491
57NEK90.89840618
58SIK20.89673547
59ERBB30.88982551
60PIK3CA0.88269848
61STK390.87640523
62STK40.85351441
63FGFR40.85026615
64ITK0.84825523
65IRAK30.82087927
66FGFR10.79411300
67CSNK1A1L0.79374562
68ALK0.78895023
69TXK0.78688411
70EPHA20.77169593
71PIK3CG0.76868224
72TTN0.76350607
73ZAK0.71523799
74ATM0.71320347
75NLK0.70235922
76PRKCH0.70084727
77RET0.68614668
78TGFBR20.67051114
79CSNK1D0.66057357
80CDK40.65843395
81MKNK20.65113124
82SMG10.64997104
83SGK10.64388687
84MAP3K70.63771401
85STK380.62971672
86DDR20.62759939
87BMX0.62728552
88CSF1R0.62314975
89MARK30.62096565
90MAP2K30.60494028
91ATR0.60044298
92TYK20.59479109
93PIM10.59095919
94ACVR1B0.58439960
95CDK70.58358421
96LRRK20.57597659
97MAP3K20.57324754
98PRKCQ0.56667880
99MAP3K60.56653467
100HCK0.56208402
101CHEK10.55821854
102TRIB30.55711455
103MAPK140.55090305
104MAPK70.53933047
105PRKAA20.53381623
106NEK20.53298484
107CDK30.52123038
108MAPK100.51787200
109RAF10.50911415
110MAPK110.50747995
111MAP3K130.49124009
112SGK4940.48343264
113SGK2230.48343264
114PLK40.47759758
115EGFR0.47504204
116TRPM70.46857455
117FER0.46612390
118GSK3A0.46514315
119MARK20.46440933
120ERBB20.46250235
121BRSK20.45946084
122STK240.44009390
123MAPK80.43866719
124MAPK10.43555808
125CSK0.43027409
126JAK20.42798745
127RPS6KB10.42481905
128CDK20.41749868
129TAF10.41526134
130PDK10.40981713
131CAMK40.40914489
132IKBKE0.40379864
133ABL10.40348298
134RIPK40.40224207
135GSK3B0.40100638
136MAP3K50.40014217
137CHEK20.39897635
138PRKAA10.39244400
139MAP3K10.39069293
140TYRO30.39004445
141PBK0.38286276
142OBSCN0.37714045
143EIF2AK20.36377541
144PDPK10.31406628
145EIF2AK10.30488785
146CDK10.28504001

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.29177732
2B cell receptor signaling pathway_Homo sapiens_hsa046621.71389226
3Chronic myeloid leukemia_Homo sapiens_hsa052201.62356522
4MicroRNAs in cancer_Homo sapiens_hsa052061.60394364
5Adherens junction_Homo sapiens_hsa045201.51459993
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.50812671
7Lysine degradation_Homo sapiens_hsa003101.46995839
8Osteoclast differentiation_Homo sapiens_hsa043801.41867969
9Small cell lung cancer_Homo sapiens_hsa052221.40520646
10Dorso-ventral axis formation_Homo sapiens_hsa043201.39666859
11Prostate cancer_Homo sapiens_hsa052151.34770596
12Pancreatic cancer_Homo sapiens_hsa052121.34555651
13Primary immunodeficiency_Homo sapiens_hsa053401.30222557
14T cell receptor signaling pathway_Homo sapiens_hsa046601.29687679
15mTOR signaling pathway_Homo sapiens_hsa041501.28365248
16Proteoglycans in cancer_Homo sapiens_hsa052051.27249518
17Type II diabetes mellitus_Homo sapiens_hsa049301.27066956
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23907255
19Toxoplasmosis_Homo sapiens_hsa051451.23621653
20Endometrial cancer_Homo sapiens_hsa052131.22551400
21Glioma_Homo sapiens_hsa052141.19928313
22Colorectal cancer_Homo sapiens_hsa052101.17644884
23FoxO signaling pathway_Homo sapiens_hsa040681.16227676
24Hepatitis B_Homo sapiens_hsa051611.14538765
25Non-small cell lung cancer_Homo sapiens_hsa052231.14369306
26TNF signaling pathway_Homo sapiens_hsa046681.13409698
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13221003
28Viral myocarditis_Homo sapiens_hsa054161.12986698
29Bladder cancer_Homo sapiens_hsa052191.11588553
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.10412186
31Cell cycle_Homo sapiens_hsa041101.10323627
32Focal adhesion_Homo sapiens_hsa045101.10072421
33* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09660029
34Leishmaniasis_Homo sapiens_hsa051401.09531483
35Renal cell carcinoma_Homo sapiens_hsa052111.08067082
36Phototransduction_Homo sapiens_hsa047441.07683180
37Insulin signaling pathway_Homo sapiens_hsa049101.07351609
38Fatty acid biosynthesis_Homo sapiens_hsa000611.06452890
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06157505
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04427316
41Viral carcinogenesis_Homo sapiens_hsa052031.04176625
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03115482
43Insulin resistance_Homo sapiens_hsa049311.03070849
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02741747
45TGF-beta signaling pathway_Homo sapiens_hsa043501.02698163
46Measles_Homo sapiens_hsa051621.00479567
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00079004
48Chemokine signaling pathway_Homo sapiens_hsa040620.98534012
49Acute myeloid leukemia_Homo sapiens_hsa052210.98530970
50Prolactin signaling pathway_Homo sapiens_hsa049170.98306097
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97847631
52ErbB signaling pathway_Homo sapiens_hsa040120.97737409
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97279304
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.96834227
55Platelet activation_Homo sapiens_hsa046110.96215302
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94506477
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.93995057
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.93133705
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92401433
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.91835063
61Hematopoietic cell lineage_Homo sapiens_hsa046400.91634704
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.90284006
63ECM-receptor interaction_Homo sapiens_hsa045120.90010803
64HTLV-I infection_Homo sapiens_hsa051660.89949404
65Herpes simplex infection_Homo sapiens_hsa051680.89419031
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88862287
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88822442
68MAPK signaling pathway_Homo sapiens_hsa040100.86710854
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86619566
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84208123
71mRNA surveillance pathway_Homo sapiens_hsa030150.83716653
72Wnt signaling pathway_Homo sapiens_hsa043100.83695104
73HIF-1 signaling pathway_Homo sapiens_hsa040660.83506630
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83218546
75AMPK signaling pathway_Homo sapiens_hsa041520.82782877
76Pathways in cancer_Homo sapiens_hsa052000.82564842
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81933368
78Influenza A_Homo sapiens_hsa051640.81785856
79Basal cell carcinoma_Homo sapiens_hsa052170.81743215
80Systemic lupus erythematosus_Homo sapiens_hsa053220.81547443
81Hippo signaling pathway_Homo sapiens_hsa043900.81315723
82GnRH signaling pathway_Homo sapiens_hsa049120.80703789
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80347955
84Antigen processing and presentation_Homo sapiens_hsa046120.79229521
85Estrogen signaling pathway_Homo sapiens_hsa049150.77528882
86Choline metabolism in cancer_Homo sapiens_hsa052310.76026454
87p53 signaling pathway_Homo sapiens_hsa041150.75588914
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75030271
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73637211
90Amoebiasis_Homo sapiens_hsa051460.73475514
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73459035
92Tuberculosis_Homo sapiens_hsa051520.72081012
93Inositol phosphate metabolism_Homo sapiens_hsa005620.71732778
94Hepatitis C_Homo sapiens_hsa051600.69765499
95Apoptosis_Homo sapiens_hsa042100.68800363
96Notch signaling pathway_Homo sapiens_hsa043300.68112011
97Renin secretion_Homo sapiens_hsa049240.67045647
98Tight junction_Homo sapiens_hsa045300.66405561
99Melanoma_Homo sapiens_hsa052180.65855854
100Circadian rhythm_Homo sapiens_hsa047100.65746927
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65487011
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64315423
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64057328
104VEGF signaling pathway_Homo sapiens_hsa043700.63454927
105Malaria_Homo sapiens_hsa051440.63192111
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62430439
107Rap1 signaling pathway_Homo sapiens_hsa040150.62067116
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.61841039
109Gap junction_Homo sapiens_hsa045400.61248604
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60599194
111Axon guidance_Homo sapiens_hsa043600.60564322
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.60436122
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60150811
114Long-term potentiation_Homo sapiens_hsa047200.60062789
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59211183
116Non-homologous end-joining_Homo sapiens_hsa034500.57905100
117Long-term depression_Homo sapiens_hsa047300.57231674
118Alcoholism_Homo sapiens_hsa050340.54811564
119Sphingolipid metabolism_Homo sapiens_hsa006000.51944549
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51451358
121Legionellosis_Homo sapiens_hsa051340.48779932
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48540833

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