MED10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.85518626
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.40735845
3respiratory electron transport chain (GO:0022904)5.03472060
4electron transport chain (GO:0022900)4.93897038
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.70235718
6protein complex biogenesis (GO:0070271)4.56786381
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.49028820
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.45458966
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.41903522
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.35823430
11termination of RNA polymerase III transcription (GO:0006386)4.35823430
127-methylguanosine mRNA capping (GO:0006370)4.29633577
13mitochondrial respiratory chain complex assembly (GO:0033108)4.26316152
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.25944284
15negative regulation of ligase activity (GO:0051352)4.25944284
16protein neddylation (GO:0045116)4.25394416
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.23891796
18NADH dehydrogenase complex assembly (GO:0010257)4.23891796
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23891796
207-methylguanosine RNA capping (GO:0009452)4.21587346
21RNA capping (GO:0036260)4.21587346
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.12392633
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.03422979
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.03422979
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.03422979
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.03380853
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.03380853
28regulation of cellular amino acid metabolic process (GO:0006521)4.01828738
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.98153261
30positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.97357847
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.90488132
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.90488132
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.87248687
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.84566026
35DNA deamination (GO:0045006)3.81418375
36mitotic metaphase plate congression (GO:0007080)3.81355891
37respiratory chain complex IV assembly (GO:0008535)3.80939619
38protein localization to mitochondrion (GO:0070585)3.80834680
39positive regulation of ligase activity (GO:0051351)3.78848861
40pseudouridine synthesis (GO:0001522)3.66769510
41protein deneddylation (GO:0000338)3.64466085
42chaperone-mediated protein transport (GO:0072321)3.63388159
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62450586
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62450586
45rRNA modification (GO:0000154)3.61154008
46cytochrome complex assembly (GO:0017004)3.60245871
47cullin deneddylation (GO:0010388)3.53328574
48protein-cofactor linkage (GO:0018065)3.49746089
49regulation of ubiquitin-protein transferase activity (GO:0051438)3.48994343
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47022268
51CENP-A containing nucleosome assembly (GO:0034080)3.41673215
52maturation of SSU-rRNA (GO:0030490)3.41091787
53transcription elongation from RNA polymerase II promoter (GO:0006368)3.40371067
54transcription-coupled nucleotide-excision repair (GO:0006283)3.39695065
55maturation of 5.8S rRNA (GO:0000460)3.38602766
56rRNA methylation (GO:0031167)3.38105058
57regulation of ligase activity (GO:0051340)3.35560463
58transcription elongation from RNA polymerase I promoter (GO:0006362)3.32471725
59DNA replication checkpoint (GO:0000076)3.32149890
60kinetochore assembly (GO:0051382)3.31866018
61platelet dense granule organization (GO:0060155)3.31191790
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30395474
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.28686361
64termination of RNA polymerase I transcription (GO:0006363)3.28070020
65DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.25551203
66chromatin remodeling at centromere (GO:0031055)3.25342165
67mannosylation (GO:0097502)3.24830800
68deoxyribose phosphate biosynthetic process (GO:0046385)3.24639619
692-deoxyribonucleotide biosynthetic process (GO:0009265)3.24639619
70positive regulation of cell cycle arrest (GO:0071158)3.24315281
71hydrogen ion transmembrane transport (GO:1902600)3.23400705
72transcription from RNA polymerase I promoter (GO:0006360)3.23375584
73base-excision repair, AP site formation (GO:0006285)3.22618424
74ribosomal small subunit biogenesis (GO:0042274)3.22284676
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17416965
76spliceosomal snRNP assembly (GO:0000387)3.16234152
77water-soluble vitamin biosynthetic process (GO:0042364)3.16027602
78ribosomal large subunit biogenesis (GO:0042273)3.15649924
79attachment of spindle microtubules to kinetochore (GO:0008608)3.15452582
80antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.14881174
81ribosomal small subunit assembly (GO:0000028)3.14863658
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14287195
83formation of translation preinitiation complex (GO:0001731)3.12957161
84DNA-templated transcription, elongation (GO:0006354)3.11680593
85inner mitochondrial membrane organization (GO:0007007)3.10042295
86cell cycle G1/S phase transition (GO:0044843)3.09463956
87G1/S transition of mitotic cell cycle (GO:0000082)3.09463956
88ribonucleoprotein complex biogenesis (GO:0022613)3.09272793
89telomere maintenance via recombination (GO:0000722)3.08959614
90sequestering of actin monomers (GO:0042989)3.08774775
91metaphase plate congression (GO:0051310)3.06666834
92purine nucleobase biosynthetic process (GO:0009113)3.06012170
93ribosome biogenesis (GO:0042254)3.05545980
94telomere maintenance via semi-conservative replication (GO:0032201)3.03168793
95mitochondrial transport (GO:0006839)3.01234329
96ribosome assembly (GO:0042255)3.00738839
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00711951
98intracellular protein transmembrane import (GO:0044743)3.00161676
99rRNA processing (GO:0006364)3.00141382
100positive regulation of viral transcription (GO:0050434)3.00100333
101negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.99533361
102ATP biosynthetic process (GO:0006754)2.99520637
103kinetochore organization (GO:0051383)2.99308561
104regulation of mitochondrial translation (GO:0070129)2.97475554
105establishment of chromosome localization (GO:0051303)2.95773037
106establishment of viral latency (GO:0019043)2.95116741
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94255719
108tRNA processing (GO:0008033)2.94217555
109proton transport (GO:0015992)2.94212615
110purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93425917
111protein targeting to mitochondrion (GO:0006626)2.93110954
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.92976487
113DNA damage response, detection of DNA damage (GO:0042769)2.92889424
114peptidyl-histidine modification (GO:0018202)2.91562759
115negative regulation of protein ubiquitination (GO:0031397)2.89383565
116regulation of cellular amine metabolic process (GO:0033238)2.88631496
117rRNA metabolic process (GO:0016072)2.88625518
118establishment of integrated proviral latency (GO:0075713)2.88532942
119hydrogen transport (GO:0006818)2.87957355
120oxidative phosphorylation (GO:0006119)2.87516039
121establishment of protein localization to mitochondrion (GO:0072655)2.86900773
122purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86284796
123histone exchange (GO:0043486)2.85014111
124DNA replication-independent nucleosome assembly (GO:0006336)2.84891211
125DNA replication-independent nucleosome organization (GO:0034724)2.84891211
126translation (GO:0006412)2.83313716
127protein K11-linked ubiquitination (GO:0070979)2.83178226
128DNA strand elongation involved in DNA replication (GO:0006271)2.82139863
129signal transduction in response to DNA damage (GO:0042770)2.81973740
130amino acid salvage (GO:0043102)2.81884172
131L-methionine salvage (GO:0071267)2.81884172
132L-methionine biosynthetic process (GO:0071265)2.81884172
133regulation of cell cycle arrest (GO:0071156)2.81707800
134ATP synthesis coupled proton transport (GO:0015986)2.80708499
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80708499
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.80128825
137transcription initiation from RNA polymerase I promoter (GO:0006361)2.79854203
138negative regulation of cell cycle G1/S phase transition (GO:1902807)2.79627968
139negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.79627968
140cellular component biogenesis (GO:0044085)2.76418480
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76390790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79423037
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.65565211
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.11884388
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02001459
5E2F7_22180533_ChIP-Seq_HELA_Human3.77080490
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.74776700
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.66179701
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.54713984
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27033091
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25249028
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93988101
12VDR_23849224_ChIP-Seq_CD4+_Human2.89339867
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83348144
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83337189
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73387160
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71036175
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64765371
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62132061
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59800175
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59612269
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55355573
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50027988
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45566939
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.45227467
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38076333
26ELK1_19687146_ChIP-ChIP_HELA_Human2.37881582
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32251370
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.21105508
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20093183
30XRN2_22483619_ChIP-Seq_HELA_Human2.19505109
31* GABP_19822575_ChIP-Seq_HepG2_Human2.10836408
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06918660
33FOXP3_21729870_ChIP-Seq_TREG_Human2.05583709
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.03823987
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.01036696
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97285462
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92722333
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91297318
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90314831
40TTF2_22483619_ChIP-Seq_HELA_Human1.86723533
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84668457
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80148436
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.74130443
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72653484
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64585091
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.64423722
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63315160
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61914043
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57916167
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57705839
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56299303
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47725681
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47253513
54* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46848647
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45849854
56ZNF274_21170338_ChIP-Seq_K562_Hela1.42637668
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39548983
58AR_21909140_ChIP-Seq_LNCAP_Human1.32560075
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.30633300
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29075306
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.28631973
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25355011
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24909499
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22836415
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22585405
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21876934
67KDM5A_27292631_Chip-Seq_BREAST_Human1.18321589
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18020690
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17796536
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15448917
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.13517683
72SPI1_23547873_ChIP-Seq_NB4_Human1.08396639
73MYC_18940864_ChIP-ChIP_HL60_Human1.07400148
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06321211
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05710903
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04388815
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03533980
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.03323120
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.02546440
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02127978
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01812638
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96715912
83CIITA_25753668_ChIP-Seq_RAJI_Human0.95542869
84VDR_22108803_ChIP-Seq_LS180_Human0.91860573
85* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90497366
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90284892
87CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90132662
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89883298
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89705733
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89580362
91TFEB_21752829_ChIP-Seq_HELA_Human0.86816641
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.86035916
93ELF5_23300383_ChIP-Seq_T47D_Human0.84102684
94TP53_22573176_ChIP-Seq_HFKS_Human0.83749795
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83668884
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83554168
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83385502
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81457326
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80335228
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80240406
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80142700
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79254425
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78591477
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78133558
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75798078
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75393958
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73931078
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72750487
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72032515
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.70578248
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69765440
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69517738
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69478492
114EWS_26573619_Chip-Seq_HEK293_Human0.69438530
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68995699
116HTT_18923047_ChIP-ChIP_STHdh_Human0.68987366
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67896827
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66351473
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.66207823
120ZNF263_19887448_ChIP-Seq_K562_Human0.64358244
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.62783271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.00434874
2MP0003806_abnormal_nucleotide_metabolis4.41897955
3MP0004957_abnormal_blastocyst_morpholog3.52367273
4MP0003718_maternal_effect3.21471864
5MP0003077_abnormal_cell_cycle3.16154792
6MP0008058_abnormal_DNA_repair3.12008068
7MP0003111_abnormal_nucleus_morphology3.05959385
8MP0010094_abnormal_chromosome_stability2.96224665
9MP0006036_abnormal_mitochondrial_physio2.77244708
10MP0008007_abnormal_cellular_replicative2.56406964
11MP0008932_abnormal_embryonic_tissue2.51081158
12MP0008057_abnormal_DNA_replication2.49530352
13MP0002736_abnormal_nociception_after2.49180704
14MP0002163_abnormal_gland_morphology2.48143323
15MP0008877_abnormal_DNA_methylation2.47571230
16MP0001835_abnormal_antigen_presentation2.40312090
17MP0003786_premature_aging2.40294230
18MP0006035_abnormal_mitochondrial_morpho2.30913453
19MP0009333_abnormal_splenocyte_physiolog2.09135769
20MP0005671_abnormal_response_to2.07005006
21MP0004142_abnormal_muscle_tone1.97706790
22MP0002148_abnormal_hypersensitivity_rea1.96137731
23MP0009785_altered_susceptibility_to1.81960512
24MP0004147_increased_porphyrin_level1.78746672
25MP0003315_abnormal_perineum_morphology1.76761659
26MP0003186_abnormal_redox_activity1.72833625
27MP0003123_paternal_imprinting1.70225844
28MP0008260_abnormal_autophagy1.70014682
29MP0001764_abnormal_homeostasis1.69647000
30MP0009046_muscle_twitch1.66794409
31MP0003880_abnormal_central_pattern1.66573975
32MP0002210_abnormal_sex_determination1.58066535
33MP0005451_abnormal_body_composition1.57986885
34MP0001968_abnormal_touch/_nociception1.55773746
35MP0001529_abnormal_vocalization1.54626608
36MP0006276_abnormal_autonomic_nervous1.53410815
37MP0006072_abnormal_retinal_apoptosis1.53399802
38MP0006082_CNS_inflammation1.52810957
39MP0006292_abnormal_olfactory_placode1.47317598
40MP0000685_abnormal_immune_system1.44521781
41MP0005075_abnormal_melanosome_morpholog1.44029864
42MP0003763_abnormal_thymus_physiology1.43902356
43MP0003950_abnormal_plasma_membrane1.43841626
44MP0008995_early_reproductive_senescence1.43380477
45MP0001542_abnormal_bone_strength1.43124779
46MP0002160_abnormal_reproductive_system1.42746029
47MP0002132_abnormal_respiratory_system1.42386994
48MP0005000_abnormal_immune_tolerance1.42126593
49MP0002102_abnormal_ear_morphology1.40849212
50MP0002837_dystrophic_cardiac_calcinosis1.31807506
51MP0001929_abnormal_gametogenesis1.31516620
52MP0002452_abnormal_antigen_presenting1.30709716
53MP0000350_abnormal_cell_proliferation1.30017978
54MP0001853_heart_inflammation1.28068587
55MP0001119_abnormal_female_reproductive1.27770302
56MP0002095_abnormal_skin_pigmentation1.26515132
57MP0001905_abnormal_dopamine_level1.25769412
58MP0001819_abnormal_immune_cell1.24742378
59MP0001984_abnormal_olfaction1.24622898
60MP0002420_abnormal_adaptive_immunity1.22801350
61MP0005310_abnormal_salivary_gland1.22168060
62MP0002723_abnormal_immune_serum1.22081492
63MP0005389_reproductive_system_phenotype1.21668728
64MP0003436_decreased_susceptibility_to1.21298422
65MP0004742_abnormal_vestibular_system1.20628088
66MP0001730_embryonic_growth_arrest1.20228017
67MP0002638_abnormal_pupillary_reflex1.20109764
68MP0005253_abnormal_eye_physiology1.19695582
69MP0001145_abnormal_male_reproductive1.19637289
70MP0008872_abnormal_physiological_respon1.19629619
71MP0001800_abnormal_humoral_immune1.19397634
72MP0000516_abnormal_urinary_system1.19234284
73MP0005367_renal/urinary_system_phenotyp1.19234284
74MP0005408_hypopigmentation1.19155941
75MP0002277_abnormal_respiratory_mucosa1.15911245
76MP0000653_abnormal_sex_gland1.15664385
77MP0002398_abnormal_bone_marrow1.12954921
78MP0000372_irregular_coat_pigmentation1.12293719
79MP0008875_abnormal_xenobiotic_pharmacok1.11215359
80MP0005499_abnormal_olfactory_system1.09180988
81MP0005394_taste/olfaction_phenotype1.09180988
82MP0005025_abnormal_response_to1.08057082
83MP0002405_respiratory_system_inflammati1.07986425
84MP0005645_abnormal_hypothalamus_physiol1.07353511
85MP0002653_abnormal_ependyma_morphology1.06204678
86MP0005395_other_phenotype1.04623149
87MP0000313_abnormal_cell_death1.04356212
88MP0000716_abnormal_immune_system1.03747474
89MP0005551_abnormal_eye_electrophysiolog1.02887582
90MP0002419_abnormal_innate_immunity1.02579730
91MP0003724_increased_susceptibility_to1.02184395
92MP0009745_abnormal_behavioral_response1.01842623
93MP0002019_abnormal_tumor_incidence1.01572230
94MP0003646_muscle_fatigue1.00469168
95MP0002272_abnormal_nervous_system0.99750441
96MP0005379_endocrine/exocrine_gland_phen0.98131498
97MP0001790_abnormal_immune_system0.97811760
98MP0005387_immune_system_phenotype0.97811760
99MP0000689_abnormal_spleen_morphology0.97281190
100MP0000490_abnormal_crypts_of0.97216644
101MP0005084_abnormal_gallbladder_morpholo0.97118791
102MP0008789_abnormal_olfactory_epithelium0.96419413
103MP0003011_delayed_dark_adaptation0.96141784
104MP0005646_abnormal_pituitary_gland0.95923463
105MP0002722_abnormal_immune_system0.93555090
106MP0002429_abnormal_blood_cell0.93052263
107MP0009764_decreased_sensitivity_to0.91003675
108MP0002876_abnormal_thyroid_physiology0.90853250
109MP0002396_abnormal_hematopoietic_system0.89166230
110MP0001919_abnormal_reproductive_system0.88609782
111MP0008873_increased_physiological_sensi0.88373907
112MP0005410_abnormal_fertilization0.86768784
113MP0000343_altered_response_to0.86684053
114MP0003136_yellow_coat_color0.86571274
115MP0001697_abnormal_embryo_size0.86064985
116MP0000749_muscle_degeneration0.85376559
117MP0003941_abnormal_skin_development0.84923915
118MP0004782_abnormal_surfactant_physiolog0.83840629
119MP0001188_hyperpigmentation0.82013345
120MP0001986_abnormal_taste_sensitivity0.81751173
121MP0001727_abnormal_embryo_implantation0.81289242
122MP0009379_abnormal_foot_pigmentation0.80866225
123MP0000858_altered_metastatic_potential0.80518862
124MP0000703_abnormal_thymus_morphology0.80453004
125MP0002933_joint_inflammation0.78574562
126MP0000049_abnormal_middle_ear0.78244289
127MP0003878_abnormal_ear_physiology0.76990791
128MP0005377_hearing/vestibular/ear_phenot0.76990791
129MP0002282_abnormal_trachea_morphology0.76332386
130MP0003121_genomic_imprinting0.75858306
131MP0002822_catalepsy0.75732133
132MP0003448_altered_tumor_morphology0.75330951
133MP0002938_white_spotting0.75283128
134MP0009697_abnormal_copulation0.74108887
135MP0002735_abnormal_chemical_nociception0.73652301
136MP0005266_abnormal_metabolism0.73295694
137MP0002751_abnormal_autonomic_nervous0.73249201
138MP0003698_abnormal_male_reproductive0.71660075
139MP0001533_abnormal_skeleton_physiology0.71221751
140MP0001485_abnormal_pinna_reflex0.70560423
141MP0002332_abnormal_exercise_endurance0.70401187
142MP0005390_skeleton_phenotype0.70281159
143MP0000358_abnormal_cell_content/0.68836119
144MP0003221_abnormal_cardiomyocyte_apopto0.68615099
145MP0000631_abnormal_neuroendocrine_gland0.68577421
146MP0005332_abnormal_amino_acid0.67490089
147MP0005636_abnormal_mineral_homeostasis0.67464729
148MP0002067_abnormal_sensory_capabilities0.66993290
149MP0001970_abnormal_pain_threshold0.65788082
150MP0005386_behavior/neurological_phenoty0.64536736
151MP0004924_abnormal_behavior0.64536736
152MP0001873_stomach_inflammation0.64244123

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)4.58940286
2Birth length less than 3rd percentile (HP:0003561)4.54459345
3Breast hypoplasia (HP:0003187)3.89120302
4Increased intramyocellular lipid droplets (HP:0012240)3.74127374
5Cerebral edema (HP:0002181)3.71836794
6Carpal bone hypoplasia (HP:0001498)3.57908578
7Lactic acidosis (HP:0003128)3.39379462
8Acute necrotizing encephalopathy (HP:0006965)3.34631338
9Generalized aminoaciduria (HP:0002909)3.23268754
10Increased muscle lipid content (HP:0009058)3.19766116
11Cerebral hypomyelination (HP:0006808)3.15330298
123-Methylglutaconic aciduria (HP:0003535)3.03272472
13Patellar aplasia (HP:0006443)2.97424670
14Respiratory failure (HP:0002878)2.97147415
15Rough bone trabeculation (HP:0100670)2.95085062
16Methylmalonic aciduria (HP:0012120)2.94418262
17Mitochondrial inheritance (HP:0001427)2.93861519
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.90399416
19Aplasia/Hypoplasia of the patella (HP:0006498)2.89885930
20Abnormal mitochondria in muscle tissue (HP:0008316)2.84702084
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.77709939
22Absent epiphyses (HP:0010577)2.77709939
23Type 2 muscle fiber atrophy (HP:0003554)2.76224910
24Small epiphyses (HP:0010585)2.75569140
25Optic disc pallor (HP:0000543)2.74854449
26Methylmalonic acidemia (HP:0002912)2.73132911
27Muscle fiber atrophy (HP:0100295)2.72293439
28Increased hepatocellular lipid droplets (HP:0006565)2.68171933
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67868984
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61061322
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60361139
32Leukodystrophy (HP:0002415)2.59632684
33Flat capital femoral epiphysis (HP:0003370)2.59203897
34Hepatocellular necrosis (HP:0001404)2.58670015
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.58351081
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58247113
37Abnormal protein N-linked glycosylation (HP:0012347)2.58247113
38Abnormal protein glycosylation (HP:0012346)2.58247113
39Abnormal glycosylation (HP:0012345)2.58247113
40Increased CSF lactate (HP:0002490)2.57073509
41Exertional dyspnea (HP:0002875)2.56190892
42Degeneration of anterior horn cells (HP:0002398)2.52849603
43Abnormality of the anterior horn cell (HP:0006802)2.52849603
44Lethargy (HP:0001254)2.50911240
45Increased IgM level (HP:0003496)2.50116549
46Type I transferrin isoform profile (HP:0003642)2.48542261
47Abnormality of renal resorption (HP:0011038)2.48091433
48Cleft eyelid (HP:0000625)2.47561602
49Amniotic constriction ring (HP:0009775)2.47302728
50Abnormality of placental membranes (HP:0011409)2.47302728
51Progressive macrocephaly (HP:0004481)2.46833011
52Abnormal trabecular bone morphology (HP:0100671)2.44228795
53CNS demyelination (HP:0007305)2.43298581
54Parakeratosis (HP:0001036)2.40889605
55Pancytopenia (HP:0001876)2.39944788
56Abnormality of glycolysis (HP:0004366)2.39920410
57Increased serum pyruvate (HP:0003542)2.39920410
58Poor head control (HP:0002421)2.39645482
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38341398
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38341398
61Emotional lability (HP:0000712)2.36278324
62Abnormal spermatogenesis (HP:0008669)2.35806082
63Abnormality of cells of the erythroid lineage (HP:0012130)2.35030541
64Secondary amenorrhea (HP:0000869)2.32055172
65Acute encephalopathy (HP:0006846)2.30059989
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.29769029
67Increased serum lactate (HP:0002151)2.25657795
68Adrenal hypoplasia (HP:0000835)2.22640893
69Lipid accumulation in hepatocytes (HP:0006561)2.21446750
70Hepatic necrosis (HP:0002605)2.19731620
71Pancreatic cysts (HP:0001737)2.18680493
72Aplastic anemia (HP:0001915)2.17515483
73Recurrent abscess formation (HP:0002722)2.17004834
74X-linked dominant inheritance (HP:0001423)2.16625058
75Reticulocytopenia (HP:0001896)2.16184609
76Oral leukoplakia (HP:0002745)2.15877110
77Microretrognathia (HP:0000308)2.13332096
78Genu varum (HP:0002970)2.13319498
79Renal Fanconi syndrome (HP:0001994)2.13002480
80Glycosuria (HP:0003076)2.12813070
81Abnormality of urine glucose concentration (HP:0011016)2.12813070
82Respiratory difficulties (HP:0002880)2.12185205
83Nausea (HP:0002018)2.10523183
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09368630
85Dicarboxylic aciduria (HP:0003215)2.09368630
86Abnormal number of erythroid precursors (HP:0012131)2.08760037
87Microvesicular hepatic steatosis (HP:0001414)2.07492918
88Meckel diverticulum (HP:0002245)2.06773473
89Progressive microcephaly (HP:0000253)2.06538097
90Abnormality of the femoral head (HP:0003368)2.06528437
91Sparse eyelashes (HP:0000653)2.05104754
92Spastic paraparesis (HP:0002313)2.05003293
93Chromsome breakage (HP:0040012)2.04927989
94Abnormality of the epiphysis of the femoral head (HP:0010574)2.04730233
95Congenital ichthyosiform erythroderma (HP:0007431)2.04140035
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.03682888
97Abnormality of femoral epiphyses (HP:0006499)2.03682888
98Pancreatic fibrosis (HP:0100732)2.03545205
99Glossoptosis (HP:0000162)2.01360475
100Hypokinesia (HP:0002375)2.01220287
101Delayed epiphyseal ossification (HP:0002663)1.99497641
102Abnormality of the pons (HP:0007361)1.98528904
103Premature graying of hair (HP:0002216)1.97116712
104Azoospermia (HP:0000027)1.96721494
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95705531
106Hypoplasia of the pons (HP:0012110)1.95515354
107Aplasia/hypoplasia of the uterus (HP:0008684)1.95047091
108Abnormality of the preputium (HP:0100587)1.93299518
109Abnormality of the ileum (HP:0001549)1.92292059
110IgG deficiency (HP:0004315)1.91738156
111Epiphyseal dysplasia (HP:0002656)1.89501512
112Short tibia (HP:0005736)1.89260449
113Recurrent bacterial skin infections (HP:0005406)1.88816064
114Macrocytic anemia (HP:0001972)1.88011242
115Congenital, generalized hypertrichosis (HP:0004540)1.87569131
116Pulmonary fibrosis (HP:0002206)1.87100144
117True hermaphroditism (HP:0010459)1.86873223
118Premature ovarian failure (HP:0008209)1.85619846
119Molar tooth sign on MRI (HP:0002419)1.85482736
120Abnormality of midbrain morphology (HP:0002418)1.85482736
121Trismus (HP:0000211)1.85021858
122CNS hypomyelination (HP:0003429)1.83638781
123Absent radius (HP:0003974)1.83472126
124Delusions (HP:0000746)1.82889095
125Exercise intolerance (HP:0003546)1.82325001
126Multiple enchondromatosis (HP:0005701)1.81302831
127Hypoplastic pelvis (HP:0008839)1.81094776
128Abnormality of methionine metabolism (HP:0010901)1.80101428
129Horseshoe kidney (HP:0000085)1.80093496
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79827656
131Renal cortical cysts (HP:0000803)1.79296598
132Abnormality of the proximal phalanges of the hand (HP:0009834)1.79280870
133Abnormal lung lobation (HP:0002101)1.78837158
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78321377
135Abnormality of alanine metabolism (HP:0010916)1.78321377
136Hyperalaninemia (HP:0003348)1.78321377
137Abnormality of serum amino acid levels (HP:0003112)1.78210266
138Recurrent pneumonia (HP:0006532)1.75975322
139Gliosis (HP:0002171)1.75762593
140Severe combined immunodeficiency (HP:0004430)1.74582185
141Poor suck (HP:0002033)1.72671418
142Constricted visual fields (HP:0001133)1.72596409
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.69485388
144Blindness (HP:0000618)1.66884026
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65395244
146Hyperphosphaturia (HP:0003109)1.63393932
147Abnormal gallbladder physiology (HP:0012438)1.62961850
148Cholecystitis (HP:0001082)1.62961850
149Hyperglycinemia (HP:0002154)1.62722880
150Posterior subcapsular cataract (HP:0007787)1.62618587
151Opisthotonus (HP:0002179)1.62159897
152Reduced antithrombin III activity (HP:0001976)1.57883719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99549560
2VRK23.80443335
3PLK43.36447205
4EIF2AK13.01656699
5NME22.94708243
6NEK12.84646095
7WEE12.82875611
8SRPK12.69749589
9PBK2.63287970
10BCKDK2.53320106
11STK162.48444835
12TRIM282.43155760
13EIF2AK32.38154092
14NME12.11182825
15PIM22.07648083
16ARAF2.06051805
17MST41.89650394
18TESK21.86628087
19VRK11.82311008
20MAP4K21.80413172
21BCR1.78813831
22DYRK21.74959339
23CDC71.69899058
24BMPR21.59700756
25IRAK41.58896729
26ACVR1B1.55530355
27BRAF1.55235376
28TESK11.52435444
29PLK11.49059316
30TSSK61.44109579
31BMPR1B1.42799653
32STK38L1.41432821
33LIMK11.39012948
34BRSK21.34223202
35ZAK1.33315174
36CSNK1G31.31564190
37MUSK1.31165094
38PLK31.27539788
39TXK1.25427954
40DAPK11.23473688
41MKNK11.19776695
42CDK81.17567371
43EIF2AK21.16414605
44NEK21.15948371
45AURKA1.15504166
46IRAK31.14288727
47DYRK31.13813831
48MAP3K141.13523327
49IKBKB1.11384575
50SIK31.08609140
51TTK1.08362154
52EPHA21.04583619
53KDR1.01977030
54AURKB0.99945295
55WNK30.98999790
56ERBB30.98819029
57CSNK1G20.96615032
58TAOK30.95485007
59RPS6KA40.95463654
60CSNK1A1L0.94768934
61CSNK1G10.94535371
62MAP3K120.92878769
63BRSK10.89107306
64MKNK20.88683632
65ABL20.88643278
66MAP2K70.88434143
67CCNB10.86400710
68STK240.84518871
69CHEK20.80858683
70TLK10.80203629
71CDK70.78950168
72PLK20.78187848
73PAK40.74115181
74CDK190.72782034
75ADRBK20.72282060
76MOS0.72053336
77ILK0.71122124
78NUAK10.70843800
79PDK20.69131708
80CSNK2A10.67285397
81NEK60.66424596
82MAP3K50.63976967
83PAK10.62154855
84RPS6KA50.61855729
85PIM10.60861431
86TBK10.60047870
87NLK0.60008480
88MINK10.58197591
89ATR0.57791501
90GRK10.57138369
91MAPKAPK30.56967265
92AKT30.56761178
93MAPK130.56676567
94MAP3K30.53063288
95CHUK0.52812535
96TGFBR10.50381539
97WNK40.50278092
98PRKCI0.49913159
99IKBKE0.48382711
100MAP3K110.47171532
101TYK20.46647765
102DAPK30.46495899
103SCYL20.45323250
104MARK30.44963643
105TAOK20.43673145
106RIPK40.43378139
107STK40.43120331
108CHEK10.42758627
109MAP3K60.42372870
110MAP3K80.42243033
111GRK70.41004720
112CSNK2A20.39283820
113CLK10.37998685
114MELK0.37871206
115STK100.37576778
116GRK50.37358471
117OXSR10.37203715
118MAPKAPK50.36310795
119BLK0.35895124
120PRKCG0.35022729
121IRAK10.34943317
122CDK30.34242278
123MYLK0.34156479
124PINK10.33875566
125ADRBK10.33659708
126CAMK2G0.33483224
127CAMK2A0.33403159
128LATS20.33198309
129JAK30.32534416
130ZAP700.31642372
131PRKCQ0.31264598
132STK30.30666307
133KIT0.30166946
134RAF10.30116151
135CSNK1A10.29899109
136FLT30.29837721

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.20167729
2RNA polymerase_Homo sapiens_hsa030204.12139768
3Ribosome_Homo sapiens_hsa030103.38255570
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13045026
5DNA replication_Homo sapiens_hsa030302.90880407
6Spliceosome_Homo sapiens_hsa030402.47271652
7Pyrimidine metabolism_Homo sapiens_hsa002402.39409924
8Basal transcription factors_Homo sapiens_hsa030222.38520822
9Mismatch repair_Homo sapiens_hsa034302.38436412
10Oxidative phosphorylation_Homo sapiens_hsa001902.36747475
11Homologous recombination_Homo sapiens_hsa034402.35930355
12Nucleotide excision repair_Homo sapiens_hsa034202.33679440
13Protein export_Homo sapiens_hsa030602.33015495
14RNA transport_Homo sapiens_hsa030132.30892048
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18839250
16Base excision repair_Homo sapiens_hsa034102.09530436
17Parkinsons disease_Homo sapiens_hsa050122.03253177
18Cell cycle_Homo sapiens_hsa041101.95259145
19Huntingtons disease_Homo sapiens_hsa050161.83545810
20RNA degradation_Homo sapiens_hsa030181.76500052
21Fanconi anemia pathway_Homo sapiens_hsa034601.56563190
22Graft-versus-host disease_Homo sapiens_hsa053321.48041063
23Sulfur metabolism_Homo sapiens_hsa009201.45708465
24Purine metabolism_Homo sapiens_hsa002301.44287262
25Allograft rejection_Homo sapiens_hsa053301.43283488
26Fatty acid elongation_Homo sapiens_hsa000621.40143510
27Epstein-Barr virus infection_Homo sapiens_hsa051691.38744873
28p53 signaling pathway_Homo sapiens_hsa041151.32234970
29Alzheimers disease_Homo sapiens_hsa050101.26381558
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23812286
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20214345
32Non-homologous end-joining_Homo sapiens_hsa034501.19171093
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17125839
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12375949
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10516191
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.05259232
37Phototransduction_Homo sapiens_hsa047441.02418951
38Autoimmune thyroid disease_Homo sapiens_hsa053200.99936103
39Asthma_Homo sapiens_hsa053100.97185387
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96010491
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95798189
42Rheumatoid arthritis_Homo sapiens_hsa053230.92792766
43Regulation of autophagy_Homo sapiens_hsa041400.91742591
44mRNA surveillance pathway_Homo sapiens_hsa030150.90164944
45Primary immunodeficiency_Homo sapiens_hsa053400.88318437
46Legionellosis_Homo sapiens_hsa051340.88147545
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.87140571
48Herpes simplex infection_Homo sapiens_hsa051680.85662529
49Vitamin B6 metabolism_Homo sapiens_hsa007500.85156676
50Peroxisome_Homo sapiens_hsa041460.82179295
51Antigen processing and presentation_Homo sapiens_hsa046120.80676657
52Selenocompound metabolism_Homo sapiens_hsa004500.80090765
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78830952
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75966251
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75696088
56Shigellosis_Homo sapiens_hsa051310.75582012
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73170199
58Steroid biosynthesis_Homo sapiens_hsa001000.72817288
59Arachidonic acid metabolism_Homo sapiens_hsa005900.72294130
60Oocyte meiosis_Homo sapiens_hsa041140.68938092
61One carbon pool by folate_Homo sapiens_hsa006700.68565157
62Folate biosynthesis_Homo sapiens_hsa007900.68070384
63Measles_Homo sapiens_hsa051620.65935387
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65545442
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64026375
66Pyruvate metabolism_Homo sapiens_hsa006200.63579758
67Collecting duct acid secretion_Homo sapiens_hsa049660.62313043
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62213921
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61698634
70Leishmaniasis_Homo sapiens_hsa051400.59638580
71Type I diabetes mellitus_Homo sapiens_hsa049400.59578541
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57248167
73Phagosome_Homo sapiens_hsa041450.56250995
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55907450
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55344653
76Synaptic vesicle cycle_Homo sapiens_hsa047210.55182187
77Propanoate metabolism_Homo sapiens_hsa006400.55108320
78Pentose phosphate pathway_Homo sapiens_hsa000300.54947371
79Apoptosis_Homo sapiens_hsa042100.54671120
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52181341
81Vibrio cholerae infection_Homo sapiens_hsa051100.52094499
82Hematopoietic cell lineage_Homo sapiens_hsa046400.50391707
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.48733721
84Ether lipid metabolism_Homo sapiens_hsa005650.47763446
85Influenza A_Homo sapiens_hsa051640.47663252
86Glutathione metabolism_Homo sapiens_hsa004800.46731657
87Sphingolipid metabolism_Homo sapiens_hsa006000.46602670
88Nicotine addiction_Homo sapiens_hsa050330.46163947
89Linoleic acid metabolism_Homo sapiens_hsa005910.45562967
90Butanoate metabolism_Homo sapiens_hsa006500.45474799
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.44512376
92Malaria_Homo sapiens_hsa051440.43758591
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43725807
94HTLV-I infection_Homo sapiens_hsa051660.42591771
95Viral carcinogenesis_Homo sapiens_hsa052030.42478168
96N-Glycan biosynthesis_Homo sapiens_hsa005100.40162054
97Carbon metabolism_Homo sapiens_hsa012000.39603166
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38884163
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37646800
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36581203
101Biosynthesis of amino acids_Homo sapiens_hsa012300.36116884
102Salmonella infection_Homo sapiens_hsa051320.35630832
103Metabolic pathways_Homo sapiens_hsa011000.35447009
104Pertussis_Homo sapiens_hsa051330.32916412
105Hepatitis B_Homo sapiens_hsa051610.31819707
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31582644
107TGF-beta signaling pathway_Homo sapiens_hsa043500.31289163
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29833693
109Viral myocarditis_Homo sapiens_hsa054160.29430855
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29373605
111Nitrogen metabolism_Homo sapiens_hsa009100.29097295
112Cardiac muscle contraction_Homo sapiens_hsa042600.29085680
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28952768
114Systemic lupus erythematosus_Homo sapiens_hsa053220.28831353
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28735176
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28239116
117Tuberculosis_Homo sapiens_hsa051520.28191746
118Other glycan degradation_Homo sapiens_hsa005110.27418078
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26345296
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26061267
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25420875
122Sulfur relay system_Homo sapiens_hsa041220.25259037
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23598626
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22318396
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.21993562
126Chemical carcinogenesis_Homo sapiens_hsa052040.21787559
127Galactose metabolism_Homo sapiens_hsa000520.20801541
128TNF signaling pathway_Homo sapiens_hsa046680.19800928
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18720069
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.18341906
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17392606
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16809822
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15562870
134T cell receptor signaling pathway_Homo sapiens_hsa046600.13278558
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10131423

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