MDS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.11208863
2fucose catabolic process (GO:0019317)4.42420985
3L-fucose metabolic process (GO:0042354)4.42420985
4L-fucose catabolic process (GO:0042355)4.42420985
5response to pheromone (GO:0019236)4.31926235
6negative regulation of telomere maintenance (GO:0032205)3.87298947
7DNA deamination (GO:0045006)3.83962724
8indolalkylamine metabolic process (GO:0006586)3.49481948
9platelet dense granule organization (GO:0060155)3.48364445
10water-soluble vitamin biosynthetic process (GO:0042364)3.43693781
11cellular ketone body metabolic process (GO:0046950)3.41913380
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.39942612
13NADH dehydrogenase complex assembly (GO:0010257)3.39942612
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39942612
15protein complex biogenesis (GO:0070271)3.35068349
16protein-cofactor linkage (GO:0018065)3.34538080
17tryptophan catabolic process (GO:0006569)3.32331005
18indole-containing compound catabolic process (GO:0042436)3.32331005
19indolalkylamine catabolic process (GO:0046218)3.32331005
20ketone body metabolic process (GO:1902224)3.24535503
21kynurenine metabolic process (GO:0070189)3.22481772
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22238260
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.19870430
24epithelial cilium movement (GO:0003351)3.18214986
25neurofilament cytoskeleton organization (GO:0060052)3.17953533
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16646247
27detection of light stimulus involved in sensory perception (GO:0050962)3.12169092
28detection of light stimulus involved in visual perception (GO:0050908)3.12169092
29protein K11-linked deubiquitination (GO:0035871)3.12039920
30neural tube formation (GO:0001841)3.09474128
31regulation of rhodopsin mediated signaling pathway (GO:0022400)3.08946268
32pyrimidine nucleobase catabolic process (GO:0006208)3.07703310
33rhodopsin mediated signaling pathway (GO:0016056)3.06225373
34mitochondrial respiratory chain complex assembly (GO:0033108)3.05493671
35preassembly of GPI anchor in ER membrane (GO:0016254)3.04123396
36ATP synthesis coupled proton transport (GO:0015986)3.00655274
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00655274
38replication fork processing (GO:0031297)2.99167464
39negative regulation of transcription regulatory region DNA binding (GO:2000678)2.98609228
40tryptophan metabolic process (GO:0006568)2.94649676
41piRNA metabolic process (GO:0034587)2.93810653
42negative regulation of translation, ncRNA-mediated (GO:0040033)2.90469321
43regulation of translation, ncRNA-mediated (GO:0045974)2.90469321
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90469321
45regulation of glucokinase activity (GO:0033131)2.89124265
46regulation of hexokinase activity (GO:1903299)2.89124265
47exogenous drug catabolic process (GO:0042738)2.86910300
48nucleobase catabolic process (GO:0046113)2.85046723
49respiratory chain complex IV assembly (GO:0008535)2.81657108
50glycerophospholipid catabolic process (GO:0046475)2.81330139
51male meiosis (GO:0007140)2.79884168
52axoneme assembly (GO:0035082)2.78360612
53protein localization to cilium (GO:0061512)2.74872271
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.74228225
55neuronal action potential (GO:0019228)2.72310373
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70184132
57dopamine transport (GO:0015872)2.69196779
58nephron epithelium morphogenesis (GO:0072088)2.68560697
59nephron tubule morphogenesis (GO:0072078)2.68560697
60kidney morphogenesis (GO:0060993)2.68233684
61cytochrome complex assembly (GO:0017004)2.67187553
62reciprocal meiotic recombination (GO:0007131)2.66933992
63reciprocal DNA recombination (GO:0035825)2.66933992
64mannosylation (GO:0097502)2.66574856
65negative regulation of mast cell activation (GO:0033004)2.66546935
66regulation of telomere maintenance (GO:0032204)2.65912175
67indole-containing compound metabolic process (GO:0042430)2.65745822
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64629085
69chaperone-mediated protein transport (GO:0072321)2.64469786
70gamma-aminobutyric acid transport (GO:0015812)2.62898045
71somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62837566
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.62837566
73cornea development in camera-type eye (GO:0061303)2.62826208
74cilium movement (GO:0003341)2.61704177
75drug catabolic process (GO:0042737)2.60801323
76nonmotile primary cilium assembly (GO:0035058)2.59755141
77positive regulation of meiosis (GO:0045836)2.57329902
78cAMP catabolic process (GO:0006198)2.56306645
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55803296
80DNA double-strand break processing (GO:0000729)2.54339486
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.54027066
82cilium morphogenesis (GO:0060271)2.52803231
83behavioral response to ethanol (GO:0048149)2.51610327
84resolution of meiotic recombination intermediates (GO:0000712)2.50262527
85RNA destabilization (GO:0050779)2.49327754
86adaptation of signaling pathway (GO:0023058)2.47468045
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46913211
88protein polyglutamylation (GO:0018095)2.46430761
89retinal cone cell development (GO:0046549)2.45317738
90recombinational repair (GO:0000725)2.43994663
91DNA methylation involved in gamete generation (GO:0043046)2.43421951
92fucosylation (GO:0036065)2.43064434
93rRNA catabolic process (GO:0016075)2.42531722
94double-strand break repair via homologous recombination (GO:0000724)2.42398784
95photoreceptor cell development (GO:0042461)2.41621254
96centriole replication (GO:0007099)2.41239935
97multicellular organism reproduction (GO:0032504)2.41181641
98cilium organization (GO:0044782)2.40190435
99male meiosis I (GO:0007141)2.39341955
100positive regulation of meiotic cell cycle (GO:0051446)2.39169523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.08565896
2VDR_22108803_ChIP-Seq_LS180_Human3.13663989
3GBX2_23144817_ChIP-Seq_PC3_Human2.85189395
4EZH2_22144423_ChIP-Seq_EOC_Human2.84987679
5IGF1R_20145208_ChIP-Seq_DFB_Human2.70619729
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54944480
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50216840
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35363145
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.31061698
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23607312
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22074333
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20102980
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08931117
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07000678
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04705673
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.04360515
17EWS_26573619_Chip-Seq_HEK293_Human2.02411791
18P300_19829295_ChIP-Seq_ESCs_Human1.94775881
19IRF1_19129219_ChIP-ChIP_H3396_Human1.93637099
20FUS_26573619_Chip-Seq_HEK293_Human1.89121688
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87589480
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76329151
23TAF15_26573619_Chip-Seq_HEK293_Human1.76026810
24ER_23166858_ChIP-Seq_MCF-7_Human1.65922176
25TP53_22573176_ChIP-Seq_HFKS_Human1.65878616
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.64434369
27BCAT_22108803_ChIP-Seq_LS180_Human1.62986308
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59413843
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.58118716
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56406792
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56144232
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52022943
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51722130
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.49448499
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46522215
36CBP_20019798_ChIP-Seq_JUKART_Human1.45810765
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45810765
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45290285
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.44289999
40AR_25329375_ChIP-Seq_VCAP_Human1.44037074
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43341026
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41751759
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41506874
44MYC_18940864_ChIP-ChIP_HL60_Human1.40882585
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40217686
46SMAD4_21799915_ChIP-Seq_A2780_Human1.39132292
47STAT3_23295773_ChIP-Seq_U87_Human1.38467255
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36819219
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36120106
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.33702028
51REST_21632747_ChIP-Seq_MESCs_Mouse1.33444034
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.33376011
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33376011
54TCF4_23295773_ChIP-Seq_U87_Human1.32971193
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32845559
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.30869104
57NANOG_19829295_ChIP-Seq_ESCs_Human1.30199898
58SOX2_19829295_ChIP-Seq_ESCs_Human1.30199898
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.30196365
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28070704
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27928983
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27203629
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.26612405
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25524164
65TCF4_22108803_ChIP-Seq_LS180_Human1.25308275
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25251988
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23987761
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23987761
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23160468
70NCOR_22424771_ChIP-Seq_293T_Human1.23145354
71RNF2_27304074_Chip-Seq_NSC_Mouse1.22238498
72AR_20517297_ChIP-Seq_VCAP_Human1.17720331
73ELK1_19687146_ChIP-ChIP_HELA_Human1.16403976
74RUNX2_22187159_ChIP-Seq_PCA_Human1.16401213
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.15769403
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15335201
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.15141459
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15093179
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12747940
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12151806
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.11999247
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.11293486
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11057866
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09941832
85AR_21572438_ChIP-Seq_LNCaP_Human1.09290320
86P53_22387025_ChIP-Seq_ESCs_Mouse1.09128507
87* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08889049
88HOXB7_26014856_ChIP-Seq_BT474_Human1.07401144
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07281875
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07010584
91VDR_23849224_ChIP-Seq_CD4+_Human1.05581837
92* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04763053
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04435360
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02777040
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02340571
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01968667
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00349922
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99948111
99NANOG_20526341_ChIP-Seq_ESCs_Human0.99929086
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99866438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.91740440
2MP0002102_abnormal_ear_morphology2.74010236
3MP0003195_calcinosis2.65548428
4MP0005551_abnormal_eye_electrophysiolog2.33657814
5MP0000372_irregular_coat_pigmentation2.28195683
6MP0002837_dystrophic_cardiac_calcinosis2.23235463
7MP0000569_abnormal_digit_pigmentation2.22934658
8MP0006292_abnormal_olfactory_placode2.13827314
9MP0005084_abnormal_gallbladder_morpholo2.11673249
10MP0002163_abnormal_gland_morphology2.11504170
11MP0008872_abnormal_physiological_respon2.04962360
12MP0004885_abnormal_endolymph2.00869504
13MP0002876_abnormal_thyroid_physiology1.99188289
14MP0003646_muscle_fatigue1.96048917
15MP0008995_early_reproductive_senescence1.94375819
16MP0001968_abnormal_touch/_nociception1.87959750
17MP0005645_abnormal_hypothalamus_physiol1.84782334
18MP0008875_abnormal_xenobiotic_pharmacok1.84371351
19MP0006072_abnormal_retinal_apoptosis1.81277394
20MP0003880_abnormal_central_pattern1.80613655
21MP0003136_yellow_coat_color1.80540412
22MP0004043_abnormal_pH_regulation1.80119857
23MP0002938_white_spotting1.77089006
24MP0004133_heterotaxia1.74248034
25MP0009745_abnormal_behavioral_response1.73264155
26MP0004142_abnormal_muscle_tone1.70442121
27MP0002653_abnormal_ependyma_morphology1.69183236
28MP0005253_abnormal_eye_physiology1.67583507
29MP0006276_abnormal_autonomic_nervous1.66755475
30MP0003787_abnormal_imprinting1.65846482
31MP0005075_abnormal_melanosome_morpholog1.65778688
32MP0002736_abnormal_nociception_after1.63435155
33MP0001986_abnormal_taste_sensitivity1.59140592
34MP0005174_abnormal_tail_pigmentation1.58507029
35MP0005379_endocrine/exocrine_gland_phen1.57214074
36MP0001501_abnormal_sleep_pattern1.56910895
37MP0003011_delayed_dark_adaptation1.55848859
38MP0009046_muscle_twitch1.54753726
39MP0002272_abnormal_nervous_system1.51862534
40MP0005646_abnormal_pituitary_gland1.49776843
41MP0004742_abnormal_vestibular_system1.48993628
42MP0000631_abnormal_neuroendocrine_gland1.46358657
43MP0001529_abnormal_vocalization1.46075231
44MP0002928_abnormal_bile_duct1.41450800
45MP0002557_abnormal_social/conspecific_i1.36596122
46MP0002638_abnormal_pupillary_reflex1.34888025
47MP0002735_abnormal_chemical_nociception1.32944057
48MP0002138_abnormal_hepatobiliary_system1.28659984
49MP0001919_abnormal_reproductive_system1.23702394
50MP0002064_seizures1.23420190
51MP0001486_abnormal_startle_reflex1.23042482
52MP0002572_abnormal_emotion/affect_behav1.21525313
53MP0005389_reproductive_system_phenotype1.12802513
54MP0001485_abnormal_pinna_reflex1.12432166
55MP0002277_abnormal_respiratory_mucosa1.11997191
56MP0004145_abnormal_muscle_electrophysio1.10799970
57MP0001970_abnormal_pain_threshold1.09054956
58MP0003283_abnormal_digestive_organ1.08549144
59MP0002095_abnormal_skin_pigmentation1.08145321
60MP0008058_abnormal_DNA_repair1.08028410
61MP0002733_abnormal_thermal_nociception1.06670905
62MP0002067_abnormal_sensory_capabilities1.05759081
63MP0005195_abnormal_posterior_eye1.05354836
64MP0003252_abnormal_bile_duct1.05220438
65MP0000427_abnormal_hair_cycle1.05150211
66MP0005085_abnormal_gallbladder_physiolo1.01023142
67MP0001905_abnormal_dopamine_level1.00838096
68MP0002160_abnormal_reproductive_system0.99827660
69MP0003806_abnormal_nucleotide_metabolis0.98624604
70MP0001984_abnormal_olfaction0.98547139
71MP0003718_maternal_effect0.97854671
72MP0001324_abnormal_eye_pigmentation0.96494511
73MP0003635_abnormal_synaptic_transmissio0.95694056
74MP0000015_abnormal_ear_pigmentation0.93867559
75MP0002234_abnormal_pharynx_morphology0.92991630
76MP0004924_abnormal_behavior0.92651421
77MP0005386_behavior/neurological_phenoty0.92651421
78MP0002254_reproductive_system_inflammat0.91246303
79MP0003698_abnormal_male_reproductive0.90233486
80MP0002752_abnormal_somatic_nervous0.90141743
81MP0002822_catalepsy0.90001277
82MP0002063_abnormal_learning/memory/cond0.88850537
83MP0001764_abnormal_homeostasis0.88604153
84MP0005167_abnormal_blood-brain_barrier0.87589020
85MP0002693_abnormal_pancreas_physiology0.85871864
86MP0005365_abnormal_bile_salt0.83935437
87MP0003786_premature_aging0.83609530
88MP0000026_abnormal_inner_ear0.83355636
89MP0002184_abnormal_innervation0.81781954
90MP0003878_abnormal_ear_physiology0.81120934
91MP0005377_hearing/vestibular/ear_phenot0.81120934
92MP0010386_abnormal_urinary_bladder0.80969010
93MP0003121_genomic_imprinting0.80562037
94MP0002210_abnormal_sex_determination0.80468094
95MP0002751_abnormal_autonomic_nervous0.80194120
96MP0005671_abnormal_response_to0.78860134
97MP0002734_abnormal_mechanical_nocicepti0.77212487
98MP0001929_abnormal_gametogenesis0.75682981
99MP0005332_abnormal_amino_acid0.73982071
100MP0010329_abnormal_lipoprotein_level0.73740697

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.10352282
2Congenital stationary night blindness (HP:0007642)4.03380626
3Molar tooth sign on MRI (HP:0002419)3.80975362
4Abnormality of midbrain morphology (HP:0002418)3.80975362
5Pancreatic fibrosis (HP:0100732)3.78744205
6Type II lissencephaly (HP:0007260)3.62423112
7True hermaphroditism (HP:0010459)3.57458941
8Nephronophthisis (HP:0000090)3.43506321
9Abnormality of the renal cortex (HP:0011035)3.26216177
10Abnormality of the renal medulla (HP:0100957)2.98685707
11Tubular atrophy (HP:0000092)2.90033095
12Abnormal drinking behavior (HP:0030082)2.85255930
13Polydipsia (HP:0001959)2.85255930
14Cerebellar dysplasia (HP:0007033)2.72905717
15Medial flaring of the eyebrow (HP:0010747)2.71386470
16Abolished electroretinogram (ERG) (HP:0000550)2.69364691
17Lissencephaly (HP:0001339)2.63108371
18Abnormal rod and cone electroretinograms (HP:0008323)2.60309347
19Inability to walk (HP:0002540)2.53491976
20Attenuation of retinal blood vessels (HP:0007843)2.52814220
21Lipid accumulation in hepatocytes (HP:0006561)2.52788866
22Mitochondrial inheritance (HP:0001427)2.52728090
23Decreased central vision (HP:0007663)2.42842297
24Increased hepatocellular lipid droplets (HP:0006565)2.42796990
25Cystic liver disease (HP:0006706)2.42426218
26Chronic hepatic failure (HP:0100626)2.42183394
27Acute necrotizing encephalopathy (HP:0006965)2.40929670
28Increased CSF lactate (HP:0002490)2.38420779
29Renal cortical cysts (HP:0000803)2.37676663
30Hypothermia (HP:0002045)2.37256033
31Polyuria (HP:0000103)2.35498776
32Hypoplasia of the fovea (HP:0007750)2.35325276
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.35325276
34Pendular nystagmus (HP:0012043)2.32879392
35Hyperventilation (HP:0002883)2.26142350
363-Methylglutaconic aciduria (HP:0003535)2.24344144
37Progressive inability to walk (HP:0002505)2.24211769
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.23164356
39Sclerocornea (HP:0000647)2.20156290
40Duplicated collecting system (HP:0000081)2.19587876
41Abnormality of the renal collecting system (HP:0004742)2.19110664
42Increased corneal curvature (HP:0100692)2.18220014
43Keratoconus (HP:0000563)2.18220014
44Pachygyria (HP:0001302)2.17027672
45Methylmalonic acidemia (HP:0002912)2.15199219
46Abnormality of the pons (HP:0007361)2.11114565
47Progressive macrocephaly (HP:0004481)2.10518109
48Acute encephalopathy (HP:0006846)2.10155384
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10088318
50Hypoplasia of the pons (HP:0012110)2.09564127
51Methylmalonic aciduria (HP:0012120)2.08150559
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06094830
53Abnormality of the fovea (HP:0000493)2.05966431
54Congenital, generalized hypertrichosis (HP:0004540)2.03652017
55Gait imbalance (HP:0002141)2.03568737
56Retinal dysplasia (HP:0007973)2.03348193
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03016076
58Abnormal mitochondria in muscle tissue (HP:0008316)2.02655868
59Stomatitis (HP:0010280)2.01950770
60Concave nail (HP:0001598)2.00766476
61Congenital hepatic fibrosis (HP:0002612)2.00066297
62Progressive cerebellar ataxia (HP:0002073)1.99643460
63Optic nerve hypoplasia (HP:0000609)1.99236879
64Nephrogenic diabetes insipidus (HP:0009806)1.99028631
65Anencephaly (HP:0002323)1.98871488
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.97741790
67Optic disc pallor (HP:0000543)1.95806543
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.94733096
69Severe muscular hypotonia (HP:0006829)1.94127200
70Focal motor seizures (HP:0011153)1.92828108
71Hepatocellular necrosis (HP:0001404)1.91985794
72Abnormality of DNA repair (HP:0003254)1.91914265
73Stomach cancer (HP:0012126)1.91749100
74Renal Fanconi syndrome (HP:0001994)1.91658613
75Congenital primary aphakia (HP:0007707)1.90648921
76Postaxial foot polydactyly (HP:0001830)1.89386874
77Hepatic necrosis (HP:0002605)1.88691348
78Gaze-evoked nystagmus (HP:0000640)1.87946054
79Ketosis (HP:0001946)1.87752269
80Ketoacidosis (HP:0001993)1.87675535
81Male pseudohermaphroditism (HP:0000037)1.86041726
82Oligodactyly (hands) (HP:0001180)1.85525342
83Absent thumb (HP:0009777)1.84844838
84Absent/shortened dynein arms (HP:0200106)1.84142404
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.84142404
86Meckel diverticulum (HP:0002245)1.84101588
87Bilateral microphthalmos (HP:0007633)1.83595401
88Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83236228
89Abnormal urine output (HP:0012590)1.82992641
90Febrile seizures (HP:0002373)1.82259710
91Hypomagnesemia (HP:0002917)1.82161631
92Large for gestational age (HP:0001520)1.81894775
93Abnormality of the ileum (HP:0001549)1.81277557
94Furrowed tongue (HP:0000221)1.79503474
95Decreased circulating renin level (HP:0003351)1.77781420
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.77402287
97Abnormal biliary tract physiology (HP:0012439)1.76324935
98Bile duct proliferation (HP:0001408)1.76324935
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74089965
100Hyperalaninemia (HP:0003348)1.74089965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.89968859
2FRK3.99140195
3TXK3.17497828
4ADRBK23.05384983
5WNK32.79276670
6BMPR1B2.46872893
7GRK12.35849793
8MAP4K22.33219586
9ZAK2.32234435
10TLK12.31652602
11PINK12.26685509
12NUAK12.20141377
13WNK42.08178716
14CASK2.05323871
15INSRR2.00886187
16MAPK132.00287072
17BCKDK1.99249340
18TNIK1.92230906
19ACVR1B1.89161196
20MAP4K11.63643635
21STK391.50860326
22MAP3K41.47409705
23MARK11.45807719
24OXSR11.34272955
25TRIM281.27524121
26DAPK21.25889227
27DYRK21.25582734
28TIE11.22804519
29CAMKK21.17174393
30MKNK21.14394267
31PAK31.10639678
32VRK11.06966943
33ADRBK11.01060753
34PRKCG1.00900405
35CSNK1G10.94610368
36PNCK0.93327349
37TAF10.88880173
38PRKCE0.87718951
39PHKG10.87201674
40PHKG20.87201674
41MAP2K70.85787219
42NLK0.80627931
43PRKCQ0.80610287
44MAPK150.76668365
45TEC0.75478240
46MUSK0.70694610
47NME10.69655615
48CSNK1G30.67795159
49CSNK1G20.67762210
50IKBKB0.64954124
51TGFBR10.64522117
52VRK20.64089891
53ERBB30.62620376
54SYK0.62448877
55STK110.62199257
56CAMK10.60704894
57PRKCI0.60430477
58IKBKE0.60169258
59NEK20.59886105
60PLK20.59526676
61NTRK20.58776028
62NTRK30.58456578
63EPHA40.57857236
64PTK2B0.54645270
65IRAK10.54342028
66PASK0.53006929
67BCR0.51700885
68PLK30.51276824
69MAP2K60.51116732
70PKN10.49890613
71CSNK1A10.46440793
72ATR0.46016009
73ITK0.45501806
74PLK40.45164743
75CAMK2A0.43108891
76PRKACA0.43007072
77BRSK20.42753512
78MST40.41940163
79DYRK1A0.41510771
80STK30.40955585
81GRK70.40825760
82TNK20.40562861
83CSNK1A1L0.40050091
84KIT0.38565062
85WEE10.38333642
86PRKCH0.36676594
87PRKCZ0.36662822
88PIK3CA0.36660653
89MAPKAPK50.36400706
90PRKCA0.36274047
91MAP3K120.36023250
92MARK30.33603659
93CHEK20.33466360
94RPS6KA50.33172914
95FGFR20.32296002
96STK160.32088218
97CHUK0.31196711
98CSNK1D0.31113541
99PRKG10.30330556
100MKNK10.29932841

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.96338202
2Oxidative phosphorylation_Homo sapiens_hsa001902.87922700
3Linoleic acid metabolism_Homo sapiens_hsa005912.63069884
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53173405
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.49597198
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44994990
7Butanoate metabolism_Homo sapiens_hsa006502.30892299
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24702812
9Parkinsons disease_Homo sapiens_hsa050122.17918482
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07142761
11Protein export_Homo sapiens_hsa030602.06353087
12Homologous recombination_Homo sapiens_hsa034402.03043278
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99978715
14Nitrogen metabolism_Homo sapiens_hsa009101.95990510
15Selenocompound metabolism_Homo sapiens_hsa004501.88790496
16Ether lipid metabolism_Homo sapiens_hsa005651.88289766
17Caffeine metabolism_Homo sapiens_hsa002321.86031138
18Fanconi anemia pathway_Homo sapiens_hsa034601.84278305
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77773362
20RNA polymerase_Homo sapiens_hsa030201.74588354
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74082340
22Nicotine addiction_Homo sapiens_hsa050331.71457149
23Basal transcription factors_Homo sapiens_hsa030221.70511151
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63586095
25Tryptophan metabolism_Homo sapiens_hsa003801.60546419
26Olfactory transduction_Homo sapiens_hsa047401.55341540
27Propanoate metabolism_Homo sapiens_hsa006401.49432507
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43148399
29Huntingtons disease_Homo sapiens_hsa050161.39205096
30Alzheimers disease_Homo sapiens_hsa050101.39136746
31RNA degradation_Homo sapiens_hsa030181.28646781
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25733425
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.24993684
34Morphine addiction_Homo sapiens_hsa050321.23390667
35Cardiac muscle contraction_Homo sapiens_hsa042601.20659241
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18607419
37Taste transduction_Homo sapiens_hsa047421.18416444
38Arachidonic acid metabolism_Homo sapiens_hsa005901.08193666
39Collecting duct acid secretion_Homo sapiens_hsa049661.07075738
40Insulin secretion_Homo sapiens_hsa049111.02763142
41Primary immunodeficiency_Homo sapiens_hsa053401.02605999
42Chemical carcinogenesis_Homo sapiens_hsa052041.00457975
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00074436
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98664844
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.98435427
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96957203
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94359217
48Peroxisome_Homo sapiens_hsa041460.94053845
49Regulation of autophagy_Homo sapiens_hsa041400.93982669
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.93321488
51Serotonergic synapse_Homo sapiens_hsa047260.90743919
52Glutamatergic synapse_Homo sapiens_hsa047240.90295317
53Circadian entrainment_Homo sapiens_hsa047130.90041807
54GABAergic synapse_Homo sapiens_hsa047270.89811059
55One carbon pool by folate_Homo sapiens_hsa006700.88568264
56Purine metabolism_Homo sapiens_hsa002300.82081712
57beta-Alanine metabolism_Homo sapiens_hsa004100.81770610
58Salivary secretion_Homo sapiens_hsa049700.80807821
59Retinol metabolism_Homo sapiens_hsa008300.80168686
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76932505
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75961879
62Ovarian steroidogenesis_Homo sapiens_hsa049130.75613635
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73356011
64Proteasome_Homo sapiens_hsa030500.71982873
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71884459
66Ribosome_Homo sapiens_hsa030100.69330992
67ABC transporters_Homo sapiens_hsa020100.68095518
68Histidine metabolism_Homo sapiens_hsa003400.65696797
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64885080
70Metabolic pathways_Homo sapiens_hsa011000.64547479
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64234651
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63650334
73Vitamin digestion and absorption_Homo sapiens_hsa049770.62140413
74Pyrimidine metabolism_Homo sapiens_hsa002400.59523987
75Fat digestion and absorption_Homo sapiens_hsa049750.58047925
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56941775
77Sulfur relay system_Homo sapiens_hsa041220.53214128
78Calcium signaling pathway_Homo sapiens_hsa040200.52727219
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51244454
80Asthma_Homo sapiens_hsa053100.50147225
81Dopaminergic synapse_Homo sapiens_hsa047280.49924252
82Type I diabetes mellitus_Homo sapiens_hsa049400.49367715
83Glycerolipid metabolism_Homo sapiens_hsa005610.48322487
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48302334
85Long-term depression_Homo sapiens_hsa047300.43826244
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43183875
87Cocaine addiction_Homo sapiens_hsa050300.43096941
88Amphetamine addiction_Homo sapiens_hsa050310.42150479
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.41313254
90Mineral absorption_Homo sapiens_hsa049780.40478688
91Circadian rhythm_Homo sapiens_hsa047100.39460480
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39237727
93Fatty acid biosynthesis_Homo sapiens_hsa000610.38642265
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38308504
95Sulfur metabolism_Homo sapiens_hsa009200.38225732
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37295016
97Fatty acid elongation_Homo sapiens_hsa000620.34128710
98Steroid biosynthesis_Homo sapiens_hsa001000.33990575
99Autoimmune thyroid disease_Homo sapiens_hsa053200.32266601
100Nucleotide excision repair_Homo sapiens_hsa034200.29049723

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