MDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.36157842
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.29250639
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.16358945
4ATP synthesis coupled proton transport (GO:0015986)6.16358945
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.81676477
6respiratory electron transport chain (GO:0022904)5.36245889
7viral transcription (GO:0019083)5.33420252
8electron transport chain (GO:0022900)5.24806508
9translational termination (GO:0006415)5.01988280
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.83766068
11ribosomal small subunit biogenesis (GO:0042274)4.82680130
12protein complex biogenesis (GO:0070271)4.81306187
13oxidative phosphorylation (GO:0006119)4.79022832
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.70800531
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.70800531
16NADH dehydrogenase complex assembly (GO:0010257)4.70800531
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.68095036
18cotranslational protein targeting to membrane (GO:0006613)4.65703172
19protein targeting to ER (GO:0045047)4.57067544
20mitochondrial respiratory chain complex assembly (GO:0033108)4.46359748
21protein localization to endoplasmic reticulum (GO:0070972)4.40241206
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37508685
23translational elongation (GO:0006414)4.37085245
24respiratory chain complex IV assembly (GO:0008535)4.25179316
25chaperone-mediated protein transport (GO:0072321)4.24771805
26viral life cycle (GO:0019058)4.03637767
27sequestering of actin monomers (GO:0042989)4.02453212
28cellular protein complex disassembly (GO:0043624)4.01083724
29maturation of SSU-rRNA (GO:0030490)3.95609782
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.89222293
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84022865
32cytochrome complex assembly (GO:0017004)3.80305213
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.79536237
34protein neddylation (GO:0045116)3.76704562
35termination of RNA polymerase III transcription (GO:0006386)3.74173407
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.74173407
37heart process (GO:0003015)3.64393997
38heart contraction (GO:0060047)3.64393997
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62350136
40metallo-sulfur cluster assembly (GO:0031163)3.59225724
41iron-sulfur cluster assembly (GO:0016226)3.59225724
42rRNA modification (GO:0000154)3.57598144
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54476608
44aerobic respiration (GO:0009060)3.49937883
45water-soluble vitamin biosynthetic process (GO:0042364)3.48810640
46translation (GO:0006412)3.46383754
47proteasome assembly (GO:0043248)3.42477519
48regulation of mitochondrial translation (GO:0070129)3.41802573
49purine-containing compound salvage (GO:0043101)3.40672627
50translational initiation (GO:0006413)3.38213444
51ribosomal large subunit biogenesis (GO:0042273)3.38142164
52ATP biosynthetic process (GO:0006754)3.37210280
53protein complex disassembly (GO:0043241)3.35404711
54behavioral response to nicotine (GO:0035095)3.33848179
55purine nucleotide salvage (GO:0032261)3.32855264
56intracellular protein transmembrane import (GO:0044743)3.32708267
57DNA deamination (GO:0045006)3.28007532
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24988507
59macromolecular complex disassembly (GO:0032984)3.24807692
60cullin deneddylation (GO:0010388)3.24117777
61inner mitochondrial membrane organization (GO:0007007)3.23922396
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.18842092
63quinone biosynthetic process (GO:1901663)3.14168696
64ubiquinone biosynthetic process (GO:0006744)3.14168696
65protein deneddylation (GO:0000338)3.12225817
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11987962
67hydrogen ion transmembrane transport (GO:1902600)3.09607737
68regulation of relaxation of muscle (GO:1901077)3.07099229
69base-excision repair, AP site formation (GO:0006285)3.06452155
70protein targeting to mitochondrion (GO:0006626)3.02986268
71platelet dense granule organization (GO:0060155)3.02383109
727-methylguanosine mRNA capping (GO:0006370)3.01751894
73ubiquinone metabolic process (GO:0006743)3.01487470
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00605697
75RNA capping (GO:0036260)2.98935079
767-methylguanosine RNA capping (GO:0009452)2.98935079
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98120256
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98120256
79peptidyl-histidine modification (GO:0018202)2.97310667
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96849538
81protein targeting to membrane (GO:0006612)2.96682276
82establishment of integrated proviral latency (GO:0075713)2.95758485
83nucleoside triphosphate biosynthetic process (GO:0009142)2.95708619
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.93563972
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.92385790
86cellular component biogenesis (GO:0044085)2.91997539
87mitochondrial transport (GO:0006839)2.90250076
88protein-cofactor linkage (GO:0018065)2.90194615
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90114751
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89831038
91negative regulation of ligase activity (GO:0051352)2.89831038
92ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87327773
93proton transport (GO:0015992)2.84357213
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83466919
95purine nucleoside monophosphate biosynthetic process (GO:0009127)2.83160118
96purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.83160118
97regulation of cilium movement (GO:0003352)2.82467169
98regulation of cellular amino acid metabolic process (GO:0006521)2.82340535
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82317808
100GTP biosynthetic process (GO:0006183)2.82212300
101establishment of protein localization to mitochondrion (GO:0072655)2.82173508
102positive regulation of mitochondrial fission (GO:0090141)2.80857890
103GPI anchor metabolic process (GO:0006505)2.80111456
104aldehyde catabolic process (GO:0046185)2.79809896
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79207873
106purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.78941946
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78079261
108transcription-coupled nucleotide-excision repair (GO:0006283)2.77105840
109positive regulation of prostaglandin secretion (GO:0032308)2.76976826
110hydrogen transport (GO:0006818)2.76866117
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76853129
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76853129
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74261212
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74261212
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74261212
116anterograde synaptic vesicle transport (GO:0048490)2.72546147
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70601167
118signal peptide processing (GO:0006465)2.69765326
119establishment of viral latency (GO:0019043)2.67173130
120negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65657692
121protein localization to mitochondrion (GO:0070585)2.63944842
122L-methionine salvage (GO:0071267)2.63435821
123L-methionine biosynthetic process (GO:0071265)2.63435821
124amino acid salvage (GO:0043102)2.63435821
125mannosylation (GO:0097502)2.62831068
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61225594
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59764692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55755452
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36101058
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.24070702
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84627012
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.69443801
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.64564331
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.51340211
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51266346
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34562286
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.19459418
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04585752
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.99374100
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83569523
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.81478914
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76394578
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67463109
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.64649182
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58478375
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43434072
20* VDR_23849224_ChIP-Seq_CD4+_Human2.41108829
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35665133
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34738581
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.28448756
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24395872
25FOXP3_21729870_ChIP-Seq_TREG_Human2.17590802
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16624563
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13598438
28* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.10503546
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.10208320
30ZNF274_21170338_ChIP-Seq_K562_Hela2.09144034
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06882389
32ELK1_19687146_ChIP-ChIP_HELA_Human2.03532128
33XRN2_22483619_ChIP-Seq_HELA_Human2.02023651
34DCP1A_22483619_ChIP-Seq_HELA_Human1.98639318
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83289895
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78856790
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77834175
38IGF1R_20145208_ChIP-Seq_DFB_Human1.77491480
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77425483
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75518409
41TTF2_22483619_ChIP-Seq_HELA_Human1.75331379
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69836253
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.69385658
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66915271
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.64007534
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63018854
47* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62566137
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61278926
49EWS_26573619_Chip-Seq_HEK293_Human1.54794547
50CIITA_25753668_ChIP-Seq_RAJI_Human1.52729057
51FUS_26573619_Chip-Seq_HEK293_Human1.51869441
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42488960
53GABP_19822575_ChIP-Seq_HepG2_Human1.42302189
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40542350
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37945519
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36583008
57MYC_18940864_ChIP-ChIP_HL60_Human1.35056309
58TAF15_26573619_Chip-Seq_HEK293_Human1.31810779
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31425757
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29926089
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27758158
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27515694
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25172282
64IRF1_19129219_ChIP-ChIP_H3396_Human1.25048473
65* TP53_22573176_ChIP-Seq_HFKS_Human1.23815302
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22749326
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22090057
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18496023
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16431831
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15754788
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12716042
72SPI1_23547873_ChIP-Seq_NB4_Human1.12093585
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12038040
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11416653
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11405242
76* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08945266
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06962494
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06300825
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05672210
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.05661963
81GATA1_22025678_ChIP-Seq_K562_Human1.04526934
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03432316
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02869641
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00740113
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00730921
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00211461
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.00071896
88P300_19829295_ChIP-Seq_ESCs_Human0.99663887
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99319876
90AR_20517297_ChIP-Seq_VCAP_Human0.98696560
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98028557
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96516181
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95849998
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95364471
95NCOR_22424771_ChIP-Seq_293T_Human0.95180929
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94248955
97* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93852306
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93709402
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.93642568
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93336291
101FOXA1_25329375_ChIP-Seq_VCAP_Human0.92767530
102FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92767530
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91937688
104KDM5A_27292631_Chip-Seq_BREAST_Human0.91060614
105EZH2_22144423_ChIP-Seq_EOC_Human0.90716594
106NANOG_19829295_ChIP-Seq_ESCs_Human0.90003986
107SOX2_19829295_ChIP-Seq_ESCs_Human0.90003986
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89342178
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88419062
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88334477
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88160766
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.87400977
113ERG_20517297_ChIP-Seq_VCAP_Human0.84341143
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82271077
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82259931
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81746562
117ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81492854
118GBX2_23144817_ChIP-Seq_PC3_Human0.80539401
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76793659
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75598608
121HTT_18923047_ChIP-ChIP_STHdh_Human0.74293119
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73132542
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.72906221
124VDR_22108803_ChIP-Seq_LS180_Human0.72755023
125E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71089919
126NANOG_20526341_ChIP-Seq_ESCs_Human0.70619300
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70583133
128STAT1_20625510_ChIP-Seq_HELA_Human0.69556867
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69069843
130ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68479146
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68213264
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68199024
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68118487
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.67980098
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.67728905
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67145372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.69933141
2MP0003136_yellow_coat_color3.24929553
3MP0001529_abnormal_vocalization2.73134302
4MP0002653_abnormal_ependyma_morphology2.65178304
5MP0000372_irregular_coat_pigmentation2.61949696
6MP0003880_abnormal_central_pattern2.54642638
7MP0004147_increased_porphyrin_level2.42174738
8MP0006072_abnormal_retinal_apoptosis2.39011926
9MP0001986_abnormal_taste_sensitivity2.38893449
10MP0006036_abnormal_mitochondrial_physio2.37483986
11MP0002837_dystrophic_cardiac_calcinosis2.35424447
12MP0005671_abnormal_response_to2.35076372
13MP0004215_abnormal_myocardial_fiber2.31154387
14MP0003806_abnormal_nucleotide_metabolis2.30515318
15MP0002938_white_spotting2.24401614
16MP0004084_abnormal_cardiac_muscle2.23531635
17MP0008789_abnormal_olfactory_epithelium2.15276343
18MP0001835_abnormal_antigen_presentation2.04638944
19MP0004142_abnormal_muscle_tone2.04063361
20MP0001905_abnormal_dopamine_level2.01456819
21MP0003763_abnormal_thymus_physiology2.00991491
22MP0010386_abnormal_urinary_bladder1.99921613
23MP0003011_delayed_dark_adaptation1.90773610
24MP0006276_abnormal_autonomic_nervous1.90516053
25MP0006035_abnormal_mitochondrial_morpho1.90414028
26MP0002822_catalepsy1.86272418
27MP0005409_darkened_coat_color1.84305132
28MP0000749_muscle_degeneration1.82940825
29MP0002638_abnormal_pupillary_reflex1.80280870
30MP0003693_abnormal_embryo_hatching1.77805009
31MP0004036_abnormal_muscle_relaxation1.77058648
32MP0005253_abnormal_eye_physiology1.75558699
33MP0005394_taste/olfaction_phenotype1.73526989
34MP0005499_abnormal_olfactory_system1.73526989
35MP0002148_abnormal_hypersensitivity_rea1.73404047
36MP0003122_maternal_imprinting1.70774938
37MP0002234_abnormal_pharynx_morphology1.66872712
38MP0008995_early_reproductive_senescence1.65282547
39MP0001764_abnormal_homeostasis1.61601967
40MP0002736_abnormal_nociception_after1.56537888
41MP0009785_altered_susceptibility_to1.55777958
42MP0002396_abnormal_hematopoietic_system1.54175938
43MP0005551_abnormal_eye_electrophysiolog1.51211658
44MP0001485_abnormal_pinna_reflex1.51119831
45MP0003718_maternal_effect1.49230387
46MP0003186_abnormal_redox_activity1.48116231
47MP0003315_abnormal_perineum_morphology1.43944105
48MP0003828_pulmonary_edema1.43835545
49MP0008877_abnormal_DNA_methylation1.41129302
50MP0002272_abnormal_nervous_system1.39660469
51MP0000751_myopathy1.39092468
52MP0003866_abnormal_defecation1.38130303
53MP0005451_abnormal_body_composition1.36709612
54MP0008058_abnormal_DNA_repair1.36284259
55MP0003950_abnormal_plasma_membrane1.36114739
56MP0009697_abnormal_copulation1.35094288
57MP0001968_abnormal_touch/_nociception1.34736532
58MP0008007_abnormal_cellular_replicative1.32635562
59MP0003137_abnormal_impulse_conducting1.32623717
60MP0002735_abnormal_chemical_nociception1.32250585
61MP0005645_abnormal_hypothalamus_physiol1.29387283
62MP0002420_abnormal_adaptive_immunity1.29380008
63MP0002132_abnormal_respiratory_system1.28683625
64MP0001819_abnormal_immune_cell1.28256111
65MP0000015_abnormal_ear_pigmentation1.26070765
66MP0003195_calcinosis1.25701614
67MP0005330_cardiomyopathy1.24801114
68MP0002972_abnormal_cardiac_muscle1.23513429
69MP0006292_abnormal_olfactory_placode1.23473657
70MP0005075_abnormal_melanosome_morpholog1.19318341
71MP0002909_abnormal_adrenal_gland1.18817033
72MP0000631_abnormal_neuroendocrine_gland1.18308943
73MP0009333_abnormal_splenocyte_physiolog1.17102174
74MP0004145_abnormal_muscle_electrophysio1.16431439
75MP0003121_genomic_imprinting1.15561075
76MP0005025_abnormal_response_to1.14751411
77MP0002876_abnormal_thyroid_physiology1.14058494
78MP0005000_abnormal_immune_tolerance1.13414925
79MP0002090_abnormal_vision1.11476308
80MP0002277_abnormal_respiratory_mucosa1.10987391
81MP0003724_increased_susceptibility_to1.10399033
82MP0001293_anophthalmia1.09064472
83MP0002160_abnormal_reproductive_system1.08968188
84MP0001800_abnormal_humoral_immune1.08304106
85MP0003283_abnormal_digestive_organ1.08299054
86MP0000920_abnormal_myelination1.07385859
87MP0002064_seizures1.07370774
88MP0002398_abnormal_bone_marrow1.07165978
89MP0000681_abnormal_thyroid_gland1.07033104
90MP0002163_abnormal_gland_morphology1.06468072
91MP0008875_abnormal_xenobiotic_pharmacok1.06297536
92MP0001544_abnormal_cardiovascular_syste1.06018943
93MP0005385_cardiovascular_system_phenoty1.06018943
94MP0005171_absent_coat_pigmentation1.05282093
95MP0002723_abnormal_immune_serum1.04678486
96MP0004133_heterotaxia1.04387955
97MP0005379_endocrine/exocrine_gland_phen1.03846917
98MP0000716_abnormal_immune_system1.03661841
99MP0001188_hyperpigmentation1.02986263
100MP0000026_abnormal_inner_ear1.02877849
101MP0008260_abnormal_autophagy1.02763838
102MP0001790_abnormal_immune_system1.02613400
103MP0005387_immune_system_phenotype1.02613400
104MP0002452_abnormal_antigen_presenting1.02268983
105MP0009745_abnormal_behavioral_response1.02083406
106MP0005174_abnormal_tail_pigmentation1.01637576
107MP0001346_abnormal_lacrimal_gland0.99983660
108MP0004043_abnormal_pH_regulation0.99188227
109MP0008775_abnormal_heart_ventricle0.99130005
110MP0000685_abnormal_immune_system0.98389399
111MP0003183_abnormal_peptide_metabolism0.98295094
112MP0002095_abnormal_skin_pigmentation0.97449981
113MP0005410_abnormal_fertilization0.96708859
114MP0005646_abnormal_pituitary_gland0.95914225
115MP0001853_heart_inflammation0.95729689
116MP0009046_muscle_twitch0.95472849
117MP0004085_abnormal_heartbeat0.94970883
118MP0002102_abnormal_ear_morphology0.94550497
119MP0006138_congestive_heart_failure0.93651336
120MP0002127_abnormal_cardiovascular_syste0.92960695
121MP0003879_abnormal_hair_cell0.92820984
122MP0002557_abnormal_social/conspecific_i0.92273223
123MP0002429_abnormal_blood_cell0.91730056
124MP0000049_abnormal_middle_ear0.91726796
125MP0000689_abnormal_spleen_morphology0.90817168
126MP0001970_abnormal_pain_threshold0.90242521
127MP0005423_abnormal_somatic_nervous0.90061138
128MP0005310_abnormal_salivary_gland0.87407132
129MP0008569_lethality_at_weaning0.87146256
130MP0001486_abnormal_startle_reflex0.86549290
131MP0008872_abnormal_physiological_respon0.86293293
132MP0002210_abnormal_sex_determination0.84525501
133MP0002722_abnormal_immune_system0.84357948
134MP0005391_vision/eye_phenotype0.83675365
135MP0002752_abnormal_somatic_nervous0.83455121
136MP0004381_abnormal_hair_follicle0.82987226
137MP0002233_abnormal_nose_morphology0.82061694
138MP0010094_abnormal_chromosome_stability0.81858070
139MP0002067_abnormal_sensory_capabilities0.80613393
140MP0005332_abnormal_amino_acid0.80415724
141MP0001929_abnormal_gametogenesis0.79864387
142MP0001756_abnormal_urination0.79478871
143MP0003698_abnormal_male_reproductive0.79208283
144MP0003787_abnormal_imprinting0.79150184
145MP0002184_abnormal_innervation0.78495238
146MP0005195_abnormal_posterior_eye0.78098542
147MP0005084_abnormal_gallbladder_morpholo0.78027858
148MP0002751_abnormal_autonomic_nervous0.76975455
149MP0010030_abnormal_orbit_morphology0.76070074
150MP0003938_abnormal_ear_development0.75936674
151MP0000569_abnormal_digit_pigmentation0.75530278
152MP0004484_altered_response_of0.74861034
153MP0001963_abnormal_hearing_physiology0.74729108
154MP0005389_reproductive_system_phenotype0.74439046
155MP0001984_abnormal_olfaction0.74258965
156MP0003786_premature_aging0.73379883
157MP0002572_abnormal_emotion/affect_behav0.73366707
158MP0008932_abnormal_embryonic_tissue0.72736985
159MP0000653_abnormal_sex_gland0.71586666
160MP0002733_abnormal_thermal_nociception0.69808945

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.18052014
2Abnormal mitochondria in muscle tissue (HP:0008316)5.90833863
3Mitochondrial inheritance (HP:0001427)5.72968794
4Hepatocellular necrosis (HP:0001404)5.69377160
5Hepatic necrosis (HP:0002605)5.14226811
6Progressive macrocephaly (HP:0004481)5.11065021
7Acute encephalopathy (HP:0006846)5.02236584
8Increased CSF lactate (HP:0002490)5.00147507
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.48880774
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.48880774
11Increased serum pyruvate (HP:0003542)4.25841634
12Abnormality of glycolysis (HP:0004366)4.25841634
133-Methylglutaconic aciduria (HP:0003535)4.12029395
14Abnormality of cells of the erythroid lineage (HP:0012130)4.11623440
15Abnormal number of erythroid precursors (HP:0012131)3.90463972
16Lactic acidosis (HP:0003128)3.66053226
17Increased serum lactate (HP:0002151)3.65890550
18Increased hepatocellular lipid droplets (HP:0006565)3.63930192
19Exercise intolerance (HP:0003546)3.61838365
20Increased intramyocellular lipid droplets (HP:0012240)3.47070561
21Renal Fanconi syndrome (HP:0001994)3.45179259
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44647317
23Microvesicular hepatic steatosis (HP:0001414)3.43674360
24Respiratory failure (HP:0002878)3.39499562
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20027220
26Optic disc pallor (HP:0000543)3.19846504
27Lipid accumulation in hepatocytes (HP:0006561)3.15557572
28Cerebral edema (HP:0002181)2.99612581
29Leukodystrophy (HP:0002415)2.93204126
30Increased muscle lipid content (HP:0009058)2.92096742
31Pancreatic cysts (HP:0001737)2.88315185
32Exertional dyspnea (HP:0002875)2.78312478
33Hypothermia (HP:0002045)2.76758178
34Macrocytic anemia (HP:0001972)2.70254236
35True hermaphroditism (HP:0010459)2.69399829
36Type I transferrin isoform profile (HP:0003642)2.67784257
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63978956
38Abnormality of alanine metabolism (HP:0010916)2.63978956
39Hyperalaninemia (HP:0003348)2.63978956
40Reticulocytopenia (HP:0001896)2.58191732
41Medial flaring of the eyebrow (HP:0010747)2.56452859
42Respiratory difficulties (HP:0002880)2.53738401
43Abnormal hair whorl (HP:0010721)2.49546907
44Hypoglycemic seizures (HP:0002173)2.44613922
45Aplastic anemia (HP:0001915)2.44493704
46Generalized aminoaciduria (HP:0002909)2.39416843
47Hyperglycinemia (HP:0002154)2.36880548
48Abnormality of midbrain morphology (HP:0002418)2.35397261
49Molar tooth sign on MRI (HP:0002419)2.35397261
50Reduced antithrombin III activity (HP:0001976)2.33707249
51Type 2 muscle fiber atrophy (HP:0003554)2.32801499
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29205905
53Pallor (HP:0000980)2.28878979
54Nephronophthisis (HP:0000090)2.28724857
55Methylmalonic aciduria (HP:0012120)2.25275993
56Hyperphosphaturia (HP:0003109)2.24489158
57Testicular atrophy (HP:0000029)2.19353467
58Congenital primary aphakia (HP:0007707)2.17336114
59Neuroendocrine neoplasm (HP:0100634)2.15621157
60Congenital, generalized hypertrichosis (HP:0004540)2.15403572
61Emotional lability (HP:0000712)2.11515026
62Gait imbalance (HP:0002141)2.11413620
63Nephrogenic diabetes insipidus (HP:0009806)2.10101351
64Abnormality of the labia minora (HP:0012880)2.10071889
65Muscle fiber atrophy (HP:0100295)2.07589877
66CNS demyelination (HP:0007305)2.00173053
67IgM deficiency (HP:0002850)1.97088935
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96772512
69Abnormal protein N-linked glycosylation (HP:0012347)1.96772512
70Abnormal protein glycosylation (HP:0012346)1.96772512
71Abnormal glycosylation (HP:0012345)1.96772512
72Poor suck (HP:0002033)1.96434494
73Calf muscle hypertrophy (HP:0008981)1.96203643
74Palpitations (HP:0001962)1.95686794
75Degeneration of the lateral corticospinal tracts (HP:0002314)1.94508573
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94508573
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92355294
78Sclerocornea (HP:0000647)1.90579590
79Muscle hypertrophy of the lower extremities (HP:0008968)1.90558110
80Abnormality of renal resorption (HP:0011038)1.90434038
81Cerebral hypomyelination (HP:0006808)1.89703556
82Pheochromocytoma (HP:0002666)1.89441741
83Symptomatic seizures (HP:0011145)1.88078127
84Opisthotonus (HP:0002179)1.87983166
85X-linked dominant inheritance (HP:0001423)1.86529377
86Colon cancer (HP:0003003)1.85295221
87Chronic otitis media (HP:0000389)1.84133346
88Glycosuria (HP:0003076)1.84024721
89Abnormality of urine glucose concentration (HP:0011016)1.84024721
90Amniotic constriction ring (HP:0009775)1.83742223
91Abnormality of placental membranes (HP:0011409)1.83742223
92Abnormal biliary tract physiology (HP:0012439)1.83291280
93Bile duct proliferation (HP:0001408)1.83291280
94Limb dystonia (HP:0002451)1.82333160
95Abnormal drinking behavior (HP:0030082)1.81544333
96Polydipsia (HP:0001959)1.81544333
97Sensory axonal neuropathy (HP:0003390)1.79710950
98Myokymia (HP:0002411)1.79645726
99Pancreatic fibrosis (HP:0100732)1.78359035
100Focal motor seizures (HP:0011153)1.77976003
101Sudden death (HP:0001699)1.77496363
102Abnormality of methionine metabolism (HP:0010901)1.75414987
103Septo-optic dysplasia (HP:0100842)1.75253803
104Ragged-red muscle fibers (HP:0003200)1.73820555
105Dicarboxylic aciduria (HP:0003215)1.73517416
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73517416
107Methylmalonic acidemia (HP:0002912)1.73039156
108Ventricular tachycardia (HP:0004756)1.72813376
109Petechiae (HP:0000967)1.72709424
110Abnormality of the heme biosynthetic pathway (HP:0010472)1.71089856
111Supraventricular tachycardia (HP:0004755)1.69687232
112Gliosis (HP:0002171)1.69066064
113Lipoatrophy (HP:0100578)1.68792142
114Abnormal respiratory epithelium morphology (HP:0012253)1.67562835
115Abnormal respiratory motile cilium morphology (HP:0005938)1.67562835
116Vomiting (HP:0002013)1.67240618
117Hypoproteinemia (HP:0003075)1.67200785
118Lissencephaly (HP:0001339)1.66968391
119Genital tract atresia (HP:0001827)1.66273655
120Ketosis (HP:0001946)1.65900069
121Absent thumb (HP:0009777)1.65890291
122Vaginal atresia (HP:0000148)1.65472452
123Blindness (HP:0000618)1.64914137
124Asplenia (HP:0001746)1.64224193
125Abnormality of vitamin B metabolism (HP:0004340)1.63951898
126Large eyes (HP:0001090)1.63865579
127Unsteady gait (HP:0002317)1.62619544
128Anencephaly (HP:0002323)1.62048470
129Thrombocytosis (HP:0001894)1.61986961
130Congenital stationary night blindness (HP:0007642)1.61920636
131Supraventricular arrhythmia (HP:0005115)1.60551912
132Pancytopenia (HP:0001876)1.59168577
133IgG deficiency (HP:0004315)1.59145246
134Parakeratosis (HP:0001036)1.57580329
135Prolonged QT interval (HP:0001657)1.57567421
136Abnormal pupillary function (HP:0007686)1.56498784
137Atrial fibrillation (HP:0005110)1.56241305
138Poor head control (HP:0002421)1.54396573
139Gastrointestinal stroma tumor (HP:0100723)1.54302680
140Lethargy (HP:0001254)1.53563926
141Exercise-induced myalgia (HP:0003738)1.53495312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.41570554
2CDK194.32702840
3CASK4.16034583
4MAP4K22.86798648
5NME22.83525161
6STK162.83017138
7MAP3K122.72368926
8MYLK2.71089266
9BUB12.45008182
10VRK12.39157318
11TNIK1.88943438
12SIK31.79596638
13MST41.79522554
14ADRBK21.78007220
15TXK1.74765130
16WNK31.66128913
17TSSK61.58454220
18FRK1.57244691
19OXSR11.56320862
20STK241.55789914
21NEK11.54593168
22TIE11.54543865
23MKNK11.54443394
24GRK71.54418278
25NME11.48378906
26CCNB11.44731340
27TEC1.42189457
28PASK1.40676261
29SRPK11.39454642
30MAPKAPK51.36269380
31IRAK41.33163320
32TLK11.32948437
33EIF2AK11.31222869
34BCR1.31130215
35CSNK1G11.29776390
36MKNK21.28754363
37CDC71.25066838
38PBK1.24675648
39CSNK1G21.24479503
40TESK21.22718852
41CSNK1A1L1.20105448
42ILK1.20022821
43PIM21.19224093
44LIMK11.18830568
45MAPK131.17238226
46MAP4K11.16322864
47TAF11.16271162
48STK391.15907991
49MAP3K41.15863866
50MUSK1.15686691
51GRK11.15550955
52OBSCN1.13480281
53PLK31.12889676
54TRIM281.12381770
55MAP2K71.11978427
56IKBKE1.11342032
57BCKDK1.02938751
58SYK1.02578202
59KIT1.00276778
60DYRK30.99704504
61DYRK20.98604071
62RPS6KA50.92342065
63BLK0.89339660
64DAPK30.85443491
65PLK10.84829714
66BTK0.84753357
67NUAK10.84642529
68PRPF4B0.82193082
69CDK80.80731584
70PRKCG0.80654050
71ERBB30.79648198
72PLK40.78979202
73ABL20.78523961
74UHMK10.77975550
75GRK50.75945741
76ITK0.75589336
77KDR0.74494299
78INSRR0.74143676
79BMPR1B0.72426211
80NEK60.72034216
81EPHA40.71535816
82EIF2AK20.69893893
83PINK10.69609210
84PKN10.65116883
85CAMK2D0.64821523
86IKBKB0.64800886
87BRAF0.64330874
88ZAP700.63725918
89LYN0.62754475
90CSNK1A10.62744941
91PRKCE0.62007189
92EIF2AK30.61411952
93MAPK150.60816307
94CDK30.60689359
95CSNK2A10.60340682
96WEE10.59059865
97CAMK2B0.58574378
98BMPR20.58137632
99CSNK2A20.57933516
100AURKA0.57806677
101ADRBK10.55021558
102MINK10.54338490
103YES10.54184650
104AURKB0.54056030
105DAPK10.52829632
106TBK10.52738157
107WNK40.52734912
108LCK0.52599520
109ATR0.51535872
110PHKG10.51433852
111PHKG20.51433852
112TYK20.51269064
113NEK20.51039655
114PLK20.50497832
115ROCK20.50188066
116MATK0.49152903
117CAMK10.48751115
118CLK10.48624521
119MAP2K60.48525714
120TESK10.47455262
121FGFR20.47120565
122PRKCQ0.47093993
123PAK30.46889598
124IRAK10.46788304
125PIK3CA0.46152744
126TGFBR10.45777351
127CSNK1G30.45486321
128EPHB10.43088956
129MAP3K140.42523086
130PRKCI0.41041631
131CHEK20.40276768
132LRRK20.39363575
133MARK30.39193612
134GRK60.38148253
135PRKACA0.38033020
136ARAF0.37083343
137ZAK0.36190040
138MAPK120.36039597
139PRKCD0.35953534
140CAMK2A0.35905990
141BRSK20.35711191
142CAMK2G0.34904248
143PAK10.34671588
144PRKACB0.33778505
145PDK20.32720990
146RPS6KA40.32558872
147FLT30.32103296

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.04129411
2Ribosome_Homo sapiens_hsa030104.87421158
3Parkinsons disease_Homo sapiens_hsa050124.55517965
4Proteasome_Homo sapiens_hsa030503.54705656
5Alzheimers disease_Homo sapiens_hsa050103.21536691
6Huntingtons disease_Homo sapiens_hsa050163.06514828
7RNA polymerase_Homo sapiens_hsa030202.73959911
8Protein export_Homo sapiens_hsa030602.59428144
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.59392810
10Cardiac muscle contraction_Homo sapiens_hsa042602.39312099
11Mismatch repair_Homo sapiens_hsa034302.18346951
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18230346
13Fatty acid elongation_Homo sapiens_hsa000622.04935482
14Homologous recombination_Homo sapiens_hsa034402.01759025
15DNA replication_Homo sapiens_hsa030301.92804180
16Nucleotide excision repair_Homo sapiens_hsa034201.76929139
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70541601
18Pyrimidine metabolism_Homo sapiens_hsa002401.63294552
19Primary immunodeficiency_Homo sapiens_hsa053401.61132474
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48683831
21Base excision repair_Homo sapiens_hsa034101.44174653
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43774151
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42013614
24Butanoate metabolism_Homo sapiens_hsa006501.30079099
25One carbon pool by folate_Homo sapiens_hsa006701.29635294
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28028985
27Spliceosome_Homo sapiens_hsa030401.27268626
28Peroxisome_Homo sapiens_hsa041461.26013632
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.25973633
30Non-homologous end-joining_Homo sapiens_hsa034501.15726279
31Purine metabolism_Homo sapiens_hsa002301.15649539
32Collecting duct acid secretion_Homo sapiens_hsa049661.07683870
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06862051
34Basal transcription factors_Homo sapiens_hsa030221.06784099
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99632544
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98791451
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91205640
38Vibrio cholerae infection_Homo sapiens_hsa051100.90655466
39Fanconi anemia pathway_Homo sapiens_hsa034600.90087188
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83007940
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82954668
42Arachidonic acid metabolism_Homo sapiens_hsa005900.80266302
43Hematopoietic cell lineage_Homo sapiens_hsa046400.79090304
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.78728926
45Nitrogen metabolism_Homo sapiens_hsa009100.76673084
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74194435
47Autoimmune thyroid disease_Homo sapiens_hsa053200.73379306
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73276018
49Allograft rejection_Homo sapiens_hsa053300.72917319
50Metabolic pathways_Homo sapiens_hsa011000.71280897
51Graft-versus-host disease_Homo sapiens_hsa053320.70525391
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67856292
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66062670
54Chemical carcinogenesis_Homo sapiens_hsa052040.64578422
55Tryptophan metabolism_Homo sapiens_hsa003800.64473817
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.63974860
57Fructose and mannose metabolism_Homo sapiens_hsa000510.63404498
58Folate biosynthesis_Homo sapiens_hsa007900.63065652
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.62778840
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62549800
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62355975
62RNA degradation_Homo sapiens_hsa030180.61163479
63Antigen processing and presentation_Homo sapiens_hsa046120.60688259
64Selenocompound metabolism_Homo sapiens_hsa004500.60343903
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58306745
66Propanoate metabolism_Homo sapiens_hsa006400.57552723
67Linoleic acid metabolism_Homo sapiens_hsa005910.57463463
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57051135
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56994384
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56033332
71Sulfur metabolism_Homo sapiens_hsa009200.54105737
72Rheumatoid arthritis_Homo sapiens_hsa053230.52429388
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51993177
74Carbon metabolism_Homo sapiens_hsa012000.51872145
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51428644
76Epstein-Barr virus infection_Homo sapiens_hsa051690.50729071
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48375992
78Systemic lupus erythematosus_Homo sapiens_hsa053220.47769997
79beta-Alanine metabolism_Homo sapiens_hsa004100.47444566
80Serotonergic synapse_Homo sapiens_hsa047260.47236517
81Pyruvate metabolism_Homo sapiens_hsa006200.47235692
82Sphingolipid metabolism_Homo sapiens_hsa006000.47165513
83Regulation of autophagy_Homo sapiens_hsa041400.45153226
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44436871
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44116870
86Vitamin B6 metabolism_Homo sapiens_hsa007500.43142149
87Sulfur relay system_Homo sapiens_hsa041220.42990987
88Pentose phosphate pathway_Homo sapiens_hsa000300.42701984
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41519612
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41290906
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40781852
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40010330
93Other glycan degradation_Homo sapiens_hsa005110.39780353
94Fatty acid degradation_Homo sapiens_hsa000710.38711759
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.38420291
96Phototransduction_Homo sapiens_hsa047440.38389226
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38088794
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36750786
99Morphine addiction_Homo sapiens_hsa050320.36640847
100Steroid biosynthesis_Homo sapiens_hsa001000.36379138
101Ether lipid metabolism_Homo sapiens_hsa005650.35817530
102Synaptic vesicle cycle_Homo sapiens_hsa047210.35344007
103Measles_Homo sapiens_hsa051620.35171302
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33005198
105Dilated cardiomyopathy_Homo sapiens_hsa054140.32863035
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.32597591
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31686757
108Alcoholism_Homo sapiens_hsa050340.31551638
109Nicotine addiction_Homo sapiens_hsa050330.30460138
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30130573
111Retinol metabolism_Homo sapiens_hsa008300.29264347
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29123831
113Glutathione metabolism_Homo sapiens_hsa004800.28974298
114Fat digestion and absorption_Homo sapiens_hsa049750.28490775
115Viral myocarditis_Homo sapiens_hsa054160.27574170
116Asthma_Homo sapiens_hsa053100.27013410
117Calcium signaling pathway_Homo sapiens_hsa040200.26810848
118N-Glycan biosynthesis_Homo sapiens_hsa005100.25387196
119Fatty acid metabolism_Homo sapiens_hsa012120.25002607
120Phagosome_Homo sapiens_hsa041450.24246351
121Tyrosine metabolism_Homo sapiens_hsa003500.23940708
122Caffeine metabolism_Homo sapiens_hsa002320.22121583
123Arginine and proline metabolism_Homo sapiens_hsa003300.21278702
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.21137908
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20898218
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20100548
127T cell receptor signaling pathway_Homo sapiens_hsa046600.20037723
128Herpes simplex infection_Homo sapiens_hsa051680.19665252
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19124643
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15419875
131RNA transport_Homo sapiens_hsa030130.14551057
132GABAergic synapse_Homo sapiens_hsa047270.12705360
133Type I diabetes mellitus_Homo sapiens_hsa049400.12343500
134Olfactory transduction_Homo sapiens_hsa047400.11895806
135Taste transduction_Homo sapiens_hsa047420.09722309

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