MDGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39768647
2locomotory exploration behavior (GO:0035641)5.37035877
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22877968
4layer formation in cerebral cortex (GO:0021819)5.22685782
5vocalization behavior (GO:0071625)5.21658517
6synaptic vesicle maturation (GO:0016188)5.00872196
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94555035
8regulation of glutamate receptor signaling pathway (GO:1900449)4.83957329
9protein localization to synapse (GO:0035418)4.74285957
10response to pheromone (GO:0019236)4.71035692
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71019044
12neuron cell-cell adhesion (GO:0007158)4.67601196
13positive regulation of synapse maturation (GO:0090129)4.67245326
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.65582148
15central nervous system projection neuron axonogenesis (GO:0021952)4.57147272
16dendritic spine morphogenesis (GO:0060997)4.57024334
17regulation of synapse structural plasticity (GO:0051823)4.44191623
18exploration behavior (GO:0035640)4.38047796
19axonal fasciculation (GO:0007413)4.37693847
20neuronal action potential propagation (GO:0019227)4.27289877
21neuron recognition (GO:0008038)4.23881393
22postsynaptic membrane organization (GO:0001941)4.18894223
23cell migration in hindbrain (GO:0021535)4.13985610
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.07069265
25neurotransmitter-gated ion channel clustering (GO:0072578)4.06212930
26pyrimidine nucleobase catabolic process (GO:0006208)3.94076096
27neurotransmitter transport (GO:0006836)3.88488926
28regulation of neuronal synaptic plasticity (GO:0048168)3.85067104
29glutamate secretion (GO:0014047)3.84787591
30regulation of synaptic vesicle exocytosis (GO:2000300)3.80558318
31dendrite morphogenesis (GO:0048813)3.80121682
32synaptic vesicle exocytosis (GO:0016079)3.79442311
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.77203181
34potassium ion homeostasis (GO:0055075)3.75821554
35regulation of synapse maturation (GO:0090128)3.72545254
36proline transport (GO:0015824)3.69535297
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69057238
38regulation of vesicle fusion (GO:0031338)3.65152383
39regulation of neurotransmitter secretion (GO:0046928)3.61938418
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61490192
41regulation of ARF protein signal transduction (GO:0032012)3.61113773
42synaptic transmission, glutamatergic (GO:0035249)3.58678883
43potassium ion import (GO:0010107)3.57461577
44cell communication by electrical coupling (GO:0010644)3.56214194
45glutamate receptor signaling pathway (GO:0007215)3.53457147
46cerebellum development (GO:0021549)3.52637009
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.50574214
48regulation of synaptic vesicle transport (GO:1902803)3.50515413
49central nervous system neuron axonogenesis (GO:0021955)3.43428991
50establishment of mitochondrion localization (GO:0051654)3.42560147
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42143602
52axon ensheathment in central nervous system (GO:0032291)3.41982962
53central nervous system myelination (GO:0022010)3.41982962
54L-amino acid import (GO:0043092)3.41603398
55cellular sodium ion homeostasis (GO:0006883)3.41112485
56cerebellar Purkinje cell differentiation (GO:0021702)3.39873083
57gamma-aminobutyric acid transport (GO:0015812)3.39270070
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38805705
59establishment of nucleus localization (GO:0040023)3.38296164
60regulation of neurotransmitter levels (GO:0001505)3.38176883
61mechanosensory behavior (GO:0007638)3.37371705
62auditory behavior (GO:0031223)3.36694369
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34228865
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.31762951
65neuronal ion channel clustering (GO:0045161)3.30715131
66positive regulation of dendritic spine development (GO:0060999)3.29244599
67regulation of neurotransmitter transport (GO:0051588)3.26828535
68positive regulation of neurotransmitter transport (GO:0051590)3.24990397
69neuromuscular process controlling posture (GO:0050884)3.23394429
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22834636
71positive regulation of membrane potential (GO:0045838)3.21457309
72neurotransmitter secretion (GO:0007269)3.21202917
73cerebellar granule cell differentiation (GO:0021707)3.20907068
74long-term memory (GO:0007616)3.20655437
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20276753
76regulation of voltage-gated calcium channel activity (GO:1901385)3.18390261
77response to auditory stimulus (GO:0010996)3.18019717
78innervation (GO:0060384)3.17413959
79mating behavior (GO:0007617)3.16699487
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16391775
81amino acid import (GO:0043090)3.16294991
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14978806
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11694472
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11575171
85regulation of dendritic spine morphogenesis (GO:0061001)3.10228115
86gamma-aminobutyric acid signaling pathway (GO:0007214)3.09089948
87adult walking behavior (GO:0007628)3.08343358
88negative regulation of microtubule polymerization (GO:0031115)3.07365719
89regulation of postsynaptic membrane potential (GO:0060078)3.06052763
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05707286
91mitochondrion transport along microtubule (GO:0047497)3.05707286
92presynaptic membrane organization (GO:0097090)3.04093792
93regulation of axon extension (GO:0030516)3.03347688
94neuron-neuron synaptic transmission (GO:0007270)3.03194760
95dendritic spine organization (GO:0097061)3.02797776
96neuromuscular synaptic transmission (GO:0007274)3.01528389
97regulation of respiratory system process (GO:0044065)3.00633316
98cellular potassium ion homeostasis (GO:0030007)3.00185914
99neuromuscular process (GO:0050905)2.99343836
100nucleobase catabolic process (GO:0046113)2.99151596
101synaptic vesicle endocytosis (GO:0048488)2.99139116
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99128057
103synapse assembly (GO:0007416)2.95720063
104positive regulation of neurotransmitter secretion (GO:0001956)2.95548415
105negative regulation of axon extension (GO:0030517)2.93737908
106axon extension (GO:0048675)2.90268042
107regulation of synaptic plasticity (GO:0048167)2.89375873
108regulation of synapse organization (GO:0050807)2.89273501
109regulation of synaptic transmission (GO:0050804)2.87096821
110neuromuscular process controlling balance (GO:0050885)2.86971159
111activation of protein kinase A activity (GO:0034199)2.85419839
112positive regulation of synapse assembly (GO:0051965)2.84419799
113cell differentiation in hindbrain (GO:0021533)2.82925177
114positive regulation of dendrite morphogenesis (GO:0050775)2.82797240
115membrane depolarization during action potential (GO:0086010)2.81646886
116positive regulation of axon extension (GO:0045773)2.81356384
117sodium ion export (GO:0071436)2.81182076
118presynaptic membrane assembly (GO:0097105)2.80485365
119learning (GO:0007612)2.80451489
120behavioral defense response (GO:0002209)2.79169225
121behavioral fear response (GO:0001662)2.79169225
122cerebellar Purkinje cell layer development (GO:0021680)2.79166512
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.77084461
124positive regulation of dendrite development (GO:1900006)2.77030454
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76122569
126membrane depolarization (GO:0051899)2.73830210
127hippocampus development (GO:0021766)2.73534571
128synapse organization (GO:0050808)2.73022531
129transmission of nerve impulse (GO:0019226)2.72111558
130cochlea development (GO:0090102)2.70700433
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68194656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.54865382
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.36503143
3GBX2_23144817_ChIP-Seq_PC3_Human3.24207205
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13725472
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.96416096
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91693471
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91693471
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91473121
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.85460734
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83601430
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.70265923
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.67960306
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.64668692
14DROSHA_22980978_ChIP-Seq_HELA_Human2.63980540
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.60748366
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57688012
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.56184096
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48878430
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48225276
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45418104
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44777147
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44266348
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32052065
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24968264
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19809420
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.18323001
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.17433055
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08307800
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04838773
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99576152
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85666111
32* RING1B_27294783_Chip-Seq_ESCs_Mouse1.78439017
33AR_21572438_ChIP-Seq_LNCaP_Human1.68644946
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68623615
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64759554
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.62060360
37* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55530271
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53306788
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52891343
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44537445
41* KDM2B_26808549_Chip-Seq_K562_Human1.43048831
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.40003992
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37277148
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36738173
45ZNF274_21170338_ChIP-Seq_K562_Hela1.35182834
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32741475
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31655817
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.30645991
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27987718
50LXR_22292898_ChIP-Seq_THP-1_Human1.27586452
51* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26836051
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25860471
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25575556
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25544948
55IGF1R_20145208_ChIP-Seq_DFB_Human1.25099381
56SMAD4_21799915_ChIP-Seq_A2780_Human1.24347314
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21662253
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21319613
59* RNF2_27304074_Chip-Seq_NSC_Mouse1.20970007
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20143892
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20019195
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19303600
63* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18727501
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17618019
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16676265
66* AR_19668381_ChIP-Seq_PC3_Human1.14910286
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.14497457
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08175657
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07267456
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.07086404
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06814974
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06814974
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06694579
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02901595
75CTCF_27219007_Chip-Seq_Bcells_Human1.02045798
76* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01558514
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.01043598
78AR_25329375_ChIP-Seq_VCAP_Human1.00261355
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00036653
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99728898
81KDM2B_26808549_Chip-Seq_JURKAT_Human0.97051558
82P300_19829295_ChIP-Seq_ESCs_Human0.96806422
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95518028
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95410344
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94786203
86* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92803546
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92496861
88* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91266662
89STAT3_23295773_ChIP-Seq_U87_Human0.90731819
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90680842
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90624261
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.88867612
93TP53_23651856_ChIP-Seq_MEFs_Mouse0.88084436
94OCT4_19829295_ChIP-Seq_ESCs_Human0.87696565
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87179452
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.87147937
97TCF4_23295773_ChIP-Seq_U87_Human0.87053209
98SMC4_20622854_ChIP-Seq_HELA_Human0.86916794
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86355216
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84707543
101DPY_21335234_ChIP-Seq_ESCs_Mouse0.84318025
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84258583
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.83348779
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82939928
105TP53_16413492_ChIP-PET_HCT116_Human0.82769020
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82111682
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81323697
108* KDM2B_26808549_Chip-Seq_DND41_Human0.80026880
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79537820
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79204669
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.78890725
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78218208
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78062857
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77836200
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.77820525
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77710539
117CREB1_26743006_Chip-Seq_LNCaP_Human0.77441148
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.77233808
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76996681
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76100712
121NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73645239
122* KLF4_19829295_ChIP-Seq_ESCs_Human0.73403118
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72123609
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.71119088
125* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70719050
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70380994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01386336
2MP0003880_abnormal_central_pattern3.98338885
3MP0005423_abnormal_somatic_nervous3.85641151
4MP0003635_abnormal_synaptic_transmissio3.50022955
5MP0004270_analgesia2.97278054
6MP0002063_abnormal_learning/memory/cond2.86010945
7MP0000778_abnormal_nervous_system2.69086084
8MP0009745_abnormal_behavioral_response2.55824071
9MP0006276_abnormal_autonomic_nervous2.39221998
10MP0004858_abnormal_nervous_system2.33816368
11MP0001968_abnormal_touch/_nociception2.31889738
12MP0002822_catalepsy2.29380105
13MP0002572_abnormal_emotion/affect_behav2.24930530
14MP0002064_seizures2.24187387
15MP0002734_abnormal_mechanical_nocicepti2.20415382
16MP0001486_abnormal_startle_reflex2.19949425
17MP0005645_abnormal_hypothalamus_physiol2.18567310
18MP0002184_abnormal_innervation2.10685666
19MP0002735_abnormal_chemical_nociception1.97615670
20MP0004811_abnormal_neuron_physiology1.91174087
21MP0001984_abnormal_olfaction1.90113310
22MP0009046_muscle_twitch1.86465510
23MP0009780_abnormal_chondrocyte_physiolo1.82077777
24MP0000751_myopathy1.80137201
25MP0002557_abnormal_social/conspecific_i1.79895930
26MP0002272_abnormal_nervous_system1.76002793
27MP0006292_abnormal_olfactory_placode1.74952728
28MP0000955_abnormal_spinal_cord1.72854972
29MP0002733_abnormal_thermal_nociception1.72774044
30MP0002736_abnormal_nociception_after1.71310441
31MP0005646_abnormal_pituitary_gland1.70066522
32MP0002067_abnormal_sensory_capabilities1.69137742
33MP0003122_maternal_imprinting1.69070255
34MP0001440_abnormal_grooming_behavior1.64084315
35MP0008569_lethality_at_weaning1.63219308
36MP0001970_abnormal_pain_threshold1.57580726
37MP0004885_abnormal_endolymph1.54732839
38MP0002882_abnormal_neuron_morphology1.51234432
39MP0003690_abnormal_glial_cell1.50966341
40MP0003123_paternal_imprinting1.50006644
41MP0003787_abnormal_imprinting1.48480855
42MP0000569_abnormal_digit_pigmentation1.43480344
43MP0003879_abnormal_hair_cell1.42175420
44MP0001501_abnormal_sleep_pattern1.40731623
45MP0000920_abnormal_myelination1.39160289
46MP0002909_abnormal_adrenal_gland1.37194060
47MP0005386_behavior/neurological_phenoty1.31810534
48MP0004924_abnormal_behavior1.31810534
49MP0002152_abnormal_brain_morphology1.29337528
50MP0005187_abnormal_penis_morphology1.29149656
51MP0000631_abnormal_neuroendocrine_gland1.26148006
52MP0003634_abnormal_glial_cell1.25695217
53MP0001348_abnormal_lacrimal_gland1.25362263
54MP0001502_abnormal_circadian_rhythm1.25015985
55MP0002102_abnormal_ear_morphology1.23769125
56MP0002066_abnormal_motor_capabilities/c1.22334431
57MP0002234_abnormal_pharynx_morphology1.21316995
58MP0005394_taste/olfaction_phenotype1.19688675
59MP0005499_abnormal_olfactory_system1.19688675
60MP0003137_abnormal_impulse_conducting1.18154851
61MP0001177_atelectasis1.17622411
62MP0003861_abnormal_nervous_system1.13485141
63MP0003632_abnormal_nervous_system1.06304525
64MP0000604_amyloidosis1.02550722
65MP0001188_hyperpigmentation1.02444769
66MP0001905_abnormal_dopamine_level1.02203507
67MP0002638_abnormal_pupillary_reflex1.00442286
68MP0008961_abnormal_basal_metabolism0.99252830
69MP0003283_abnormal_digestive_organ0.98373756
70MP0004215_abnormal_myocardial_fiber0.96986371
71MP0005623_abnormal_meninges_morphology0.94702423
72MP0003646_muscle_fatigue0.94575889
73MP0008789_abnormal_olfactory_epithelium0.94170984
74MP0004085_abnormal_heartbeat0.93562481
75MP0002229_neurodegeneration0.93128376
76MP0002938_white_spotting0.92097361
77MP0003329_amyloid_beta_deposits0.91476502
78MP0001299_abnormal_eye_distance/0.89590400
79MP0002752_abnormal_somatic_nervous0.89249856
80MP0003121_genomic_imprinting0.88022322
81MP0004130_abnormal_muscle_cell0.86201082
82MP0003938_abnormal_ear_development0.85595836
83MP0000026_abnormal_inner_ear0.80363832
84MP0002069_abnormal_eating/drinking_beha0.80296951
85MP0003633_abnormal_nervous_system0.80067040
86MP0008874_decreased_physiological_sensi0.77831590
87MP0001963_abnormal_hearing_physiology0.77142062
88MP0000049_abnormal_middle_ear0.76948105
89MP0004742_abnormal_vestibular_system0.75377114
90MP0004142_abnormal_muscle_tone0.74191489
91MP0003705_abnormal_hypodermis_morpholog0.72649205
92MP0002089_abnormal_postnatal_growth/wei0.71524618
93MP0002081_perinatal_lethality0.71342804
94MP0000579_abnormal_nail_morphology0.71129222
95MP0004233_abnormal_muscle_weight0.70772723
96MP0002653_abnormal_ependyma_morphology0.70345519
97MP0005551_abnormal_eye_electrophysiolog0.70187255
98MP0008995_early_reproductive_senescence0.69625114
99MP0002249_abnormal_larynx_morphology0.69474728
100MP0010769_abnormal_survival0.68229287
101MP0001958_emphysema0.68187110
102MP0010770_preweaning_lethality0.66826689
103MP0002082_postnatal_lethality0.66826689
104MP0002837_dystrophic_cardiac_calcinosis0.66662137
105MP0001529_abnormal_vocalization0.66438831
106MP0010768_mortality/aging0.65073895
107MP0003385_abnormal_body_wall0.64792134
108MP0002751_abnormal_autonomic_nervous0.64294933
109MP0005535_abnormal_body_temperature0.63864591
110MP0003631_nervous_system_phenotype0.63762832
111MP0005409_darkened_coat_color0.63076413
112MP0001943_abnormal_respiration0.61641272
113MP0010386_abnormal_urinary_bladder0.61439787
114MP0001346_abnormal_lacrimal_gland0.60458529
115MP0000534_abnormal_ureter_morphology0.60221157
116MP0006072_abnormal_retinal_apoptosis0.60039095
117MP0003045_fibrosis0.59666530
118MP0000537_abnormal_urethra_morphology0.59406469
119MP0004145_abnormal_muscle_electrophysio0.58436047
120MP0003172_abnormal_lysosome_physiology0.57649809
121MP0002116_abnormal_craniofacial_bone0.57579951
122MP0004510_myositis0.56755327
123MP0003279_aneurysm0.56491664
124MP0005167_abnormal_blood-brain_barrier0.54318360
125MP0005257_abnormal_intraocular_pressure0.53814324

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.79622637
2Myokymia (HP:0002411)4.64675048
3Neurofibrillary tangles (HP:0002185)4.41163205
4Focal seizures (HP:0007359)3.87288107
5Annular pancreas (HP:0001734)3.80829858
6Visual hallucinations (HP:0002367)3.61566724
7Epileptic encephalopathy (HP:0200134)3.60428223
8Cerebral inclusion bodies (HP:0100314)3.60081104
9Spastic gait (HP:0002064)3.57454481
10Hyperacusis (HP:0010780)3.43249595
11Insomnia (HP:0100785)3.37733781
12Progressive cerebellar ataxia (HP:0002073)3.31976927
13Supranuclear gaze palsy (HP:0000605)3.28928300
14Elfin facies (HP:0004428)3.12237532
15Hemiplegia (HP:0002301)3.11439045
16Febrile seizures (HP:0002373)3.05576250
17Mutism (HP:0002300)3.03568360
18Obstructive sleep apnea (HP:0002870)2.87797578
19Broad-based gait (HP:0002136)2.84210492
20Dysmetria (HP:0001310)2.81529636
21Ankle clonus (HP:0011448)2.81168647
22Papilledema (HP:0001085)2.79382695
23Overriding aorta (HP:0002623)2.78578227
24Craniofacial dystonia (HP:0012179)2.77417630
25Drooling (HP:0002307)2.74535346
26Excessive salivation (HP:0003781)2.74535346
27Poor eye contact (HP:0000817)2.71998058
28Intention tremor (HP:0002080)2.62885701
29Tetraplegia (HP:0002445)2.61853312
30Cerebral hypomyelination (HP:0006808)2.60374750
31Genetic anticipation (HP:0003743)2.60159153
32Turricephaly (HP:0000262)2.60012240
33Pointed chin (HP:0000307)2.59060973
34Absence seizures (HP:0002121)2.55693502
35Flat cornea (HP:0007720)2.54836892
36Impaired smooth pursuit (HP:0007772)2.53659811
37Renovascular hypertension (HP:0100817)2.52793887
38Depression (HP:0000716)2.47793198
39Polyphagia (HP:0002591)2.46384233
40Cerebral aneurysm (HP:0004944)2.46045263
41Renal duplication (HP:0000075)2.45621469
42Megalencephaly (HP:0001355)2.43714050
43Generalized tonic-clonic seizures (HP:0002069)2.42668857
44Hemiparesis (HP:0001269)2.42455732
45Aqueductal stenosis (HP:0002410)2.41859514
46Action tremor (HP:0002345)2.41024841
47Akinesia (HP:0002304)2.40887618
48Sleep apnea (HP:0010535)2.40840357
49Lower limb muscle weakness (HP:0007340)2.39868032
50Hyperventilation (HP:0002883)2.37266752
51Impaired vibration sensation in the lower limbs (HP:0002166)2.35620500
52Neuronal loss in central nervous system (HP:0002529)2.31198296
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29951933
54Short 4th metacarpal (HP:0010044)2.29951933
55Hand muscle atrophy (HP:0009130)2.29021055
56Abnormal social behavior (HP:0012433)2.28040223
57Impaired social interactions (HP:0000735)2.28040223
58Truncal ataxia (HP:0002078)2.27032205
59Abnormal eating behavior (HP:0100738)2.25604235
60Lissencephaly (HP:0001339)2.24046154
61Abnormality of ocular smooth pursuit (HP:0000617)2.22778991
62Inappropriate behavior (HP:0000719)2.21796975
63Stereotypic behavior (HP:0000733)2.21765721
64Peripheral hypomyelination (HP:0007182)2.20557696
65Atonic seizures (HP:0010819)2.17965150
66Status epilepticus (HP:0002133)2.16627169
67Distal upper limb amyotrophy (HP:0007149)2.14877932
68Upper limb amyotrophy (HP:0009129)2.14877932
69Sacral dimple (HP:0000960)2.14310563
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.13806539
71Hypoplasia of the brainstem (HP:0002365)2.13806539
72Dialeptic seizures (HP:0011146)2.13465006
73Bradykinesia (HP:0002067)2.13172664
74Open mouth (HP:0000194)2.12663859
75Failure to thrive in infancy (HP:0001531)2.11837085
76Rapidly progressive (HP:0003678)2.11012748
77Abnormality of the lower motor neuron (HP:0002366)2.10931334
78Amyotrophic lateral sclerosis (HP:0007354)2.09952174
79Urinary bladder sphincter dysfunction (HP:0002839)2.09401521
80Pachygyria (HP:0001302)2.08659940
81Abnormal EKG (HP:0003115)2.07352370
82Lower limb asymmetry (HP:0100559)2.07216133
83Amblyopia (HP:0000646)2.07190645
84Obsessive-compulsive behavior (HP:0000722)2.05989619
85Ventricular fibrillation (HP:0001663)2.04444211
86Neoplasm of the heart (HP:0100544)2.02310311
87Bowel diverticulosis (HP:0005222)2.00820709
88Abnormality of the astrocytes (HP:0100707)2.00033275
89Astrocytoma (HP:0009592)2.00033275
90Hepatoblastoma (HP:0002884)1.99557942
91Clonus (HP:0002169)1.99249123
92Torticollis (HP:0000473)1.99061319
93Urinary urgency (HP:0000012)1.99023367
94Spastic tetraparesis (HP:0001285)1.97692858
95Morphological abnormality of the pyramidal tract (HP:0002062)1.97141776
96Megalocornea (HP:0000485)1.96750100
97Diminished motivation (HP:0000745)1.96414514
98Shallow orbits (HP:0000586)1.95518801
99Postural instability (HP:0002172)1.95166055
100Hypoventilation (HP:0002791)1.93773526
101Hypsarrhythmia (HP:0002521)1.92961140
102Anxiety (HP:0000739)1.92778805
103Prolonged QT interval (HP:0001657)1.92467233
104Broad metatarsal (HP:0001783)1.91076365
105Absent speech (HP:0001344)1.90623878
106Aplasia involving bones of the upper limbs (HP:0009823)1.90452403
107Aplasia of the phalanges of the hand (HP:0009802)1.90452403
108Aplasia involving bones of the extremities (HP:0009825)1.90452403
109Mild short stature (HP:0003502)1.90346320
110Fetal akinesia sequence (HP:0001989)1.90317104
111Lower limb amyotrophy (HP:0007210)1.89436861
112Diplopia (HP:0000651)1.87329407
113Abnormality of binocular vision (HP:0011514)1.87329407
114Hammertoe (HP:0001765)1.87061001
115Protruding tongue (HP:0010808)1.87040118
116Abnormality of the corticospinal tract (HP:0002492)1.86605392
117Bronchomalacia (HP:0002780)1.86052951
118Rigidity (HP:0002063)1.85257678
119Epileptiform EEG discharges (HP:0011182)1.84879999
120Bundle branch block (HP:0011710)1.84734142
121Agitation (HP:0000713)1.82410780
122Progressive inability to walk (HP:0002505)1.81907202
123Gaze-evoked nystagmus (HP:0000640)1.81649004
124Primary atrial arrhythmia (HP:0001692)1.80805621
125Apathy (HP:0000741)1.80366709
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79711538
127Autism (HP:0000717)1.79465316
128Spinal canal stenosis (HP:0003416)1.79294626
129EEG with generalized epileptiform discharges (HP:0011198)1.79239381
130Scanning speech (HP:0002168)1.79071934
131Inability to walk (HP:0002540)1.78985766
132Abnormality of the diencephalon (HP:0010662)1.78149976
133Dysdiadochokinesis (HP:0002075)1.75528895
134Incomplete penetrance (HP:0003829)1.75418690
135Periorbital edema (HP:0100539)1.75351831
136Sudden death (HP:0001699)1.74040930
137Focal dystonia (HP:0004373)1.73914217
138Supraventricular tachycardia (HP:0004755)1.73097560
139Macroorchidism (HP:0000053)1.72708092
140Abnormality of salivation (HP:0100755)1.72339487
141Limb dystonia (HP:0002451)1.72291691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.81005938
2NTRK33.56297088
3TNIK3.15055046
4MAP3K92.87996075
5MINK12.76484061
6SIK22.66620266
7MAP3K42.62090372
8NTRK22.54476801
9MAP2K72.44527735
10EPHA42.36754972
11PHKG12.21241992
12PHKG22.21241992
13MAPK132.12171076
14PAK62.03182153
15SIK31.87036036
16KSR11.85677068
17DAPK21.64050262
18CAMKK11.61848606
19MAP3K121.58071532
20LATS21.54313811
21CASK1.46018498
22ERBB31.45389594
23MAP2K41.41632640
24DAPK11.39802837
25EPHB21.36046342
26MARK21.35347854
27CDK51.34016016
28LMTK21.25010712
29PRKD31.24426009
30DYRK21.22319494
31CAMKK21.20525561
32WNK11.19468173
33PRPF4B1.14507713
34ARAF1.14339186
35UHMK11.10755752
36CAMK11.10027085
37CAMK2B1.04674829
38STK381.01375238
39NTRK10.99201513
40TAOK10.99142273
41DMPK0.95163699
42ALK0.93679076
43PKN10.92914547
44FES0.90574581
45MAP3K70.89709994
46RPS6KA20.87040104
47EEF2K0.82141059
48CDK180.81771514
49PRKCG0.79796124
50ICK0.79249059
51TYRO30.78873058
52CDK190.78332706
53CDK150.76939555
54CSNK1G20.75730179
55PDGFRA0.72777929
56PKN20.72510067
57ROCK20.71229559
58STK110.71131472
59CDK11A0.70248589
60TAOK20.70103151
61ERBB20.69413637
62RET0.68282561
63MOS0.67762291
64MAP3K60.67304419
65MAPK120.67030481
66PAK30.66681729
67CDK140.66270549
68MAP3K130.66114518
69CAMK40.65963002
70CAMK2G0.65443413
71CDC42BPA0.65288594
72TRIB30.64953423
73RIPK10.64133097
74CAMK1G0.62908193
75PLK20.62803923
76RIPK40.61782712
77SGK20.60298940
78LIMK10.59616267
79CAMK2A0.58012121
80KSR20.57744128
81CDK80.55961685
82RAF10.54736042
83DYRK1B0.53483289
84DYRK1A0.52903067
85PRKCH0.52896292
86CAMK1D0.52499308
87PRKCZ0.52372324
88SGK4940.52124452
89SGK2230.52124452
90PDK10.51372851
91CCNB10.50459386
92PINK10.48997730
93SGK30.48683446
94ILK0.48135158
95PDPK10.48050793
96GRK50.47771291
97CSNK1A1L0.47551855
98MAPK90.47367848
99DDR20.46661619
100CAMK2D0.45431562
101MATK0.45188833
102PNCK0.44532104
103WNK30.44169918
104CSNK1G30.43784769
105DAPK30.43199808
106SGK10.42931137
107MAP3K110.42724826
108NEK60.42230034
109NEK10.42021326
110FYN0.41979224
111SIK10.40409256
112MAPK80.39638590
113RPS6KA30.39540269
114TESK10.39394222
115BRAF0.37145914
116ROCK10.36936406
117MAPK100.35087995
118BRSK10.35009457
119SCYL20.33538588
120FER0.33082792
121FGFR20.32910194
122SRC0.32564382
123GSK3B0.32067145
124PAK20.29698643

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12322907
2Circadian entrainment_Homo sapiens_hsa047132.46772206
3Olfactory transduction_Homo sapiens_hsa047402.41537726
4Synaptic vesicle cycle_Homo sapiens_hsa047212.26489795
5Glutamatergic synapse_Homo sapiens_hsa047242.24109136
6GABAergic synapse_Homo sapiens_hsa047272.22458912
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13388027
8Morphine addiction_Homo sapiens_hsa050322.10021630
9Long-term potentiation_Homo sapiens_hsa047202.01237456
10Dopaminergic synapse_Homo sapiens_hsa047281.89759684
11Axon guidance_Homo sapiens_hsa043601.88276975
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85749078
13Amphetamine addiction_Homo sapiens_hsa050311.83744730
14Cholinergic synapse_Homo sapiens_hsa047251.78785004
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76294543
16Insulin secretion_Homo sapiens_hsa049111.71286836
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70841526
18Salivary secretion_Homo sapiens_hsa049701.70186319
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68367887
20Gastric acid secretion_Homo sapiens_hsa049711.58647683
21Oxytocin signaling pathway_Homo sapiens_hsa049211.56445794
22Glioma_Homo sapiens_hsa052141.49948477
23Calcium signaling pathway_Homo sapiens_hsa040201.46497581
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45919034
25Gap junction_Homo sapiens_hsa045401.43220180
26Taste transduction_Homo sapiens_hsa047421.42182105
27GnRH signaling pathway_Homo sapiens_hsa049121.37983116
28Serotonergic synapse_Homo sapiens_hsa047261.36370056
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35561236
30Cocaine addiction_Homo sapiens_hsa050301.33511385
31ErbB signaling pathway_Homo sapiens_hsa040121.33172672
32Long-term depression_Homo sapiens_hsa047301.33010243
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29863851
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28714157
35Renin secretion_Homo sapiens_hsa049241.28442063
36Dilated cardiomyopathy_Homo sapiens_hsa054141.24497660
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24222872
38cAMP signaling pathway_Homo sapiens_hsa040241.23250411
39Endometrial cancer_Homo sapiens_hsa052131.21346627
40Colorectal cancer_Homo sapiens_hsa052101.19395032
41Estrogen signaling pathway_Homo sapiens_hsa049151.18058325
42Type II diabetes mellitus_Homo sapiens_hsa049301.17568913
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15352624
44Melanogenesis_Homo sapiens_hsa049161.15239560
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.08940879
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01430903
47Wnt signaling pathway_Homo sapiens_hsa043100.99532142
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99446963
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93308660
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92431022
51Basal cell carcinoma_Homo sapiens_hsa052170.92016036
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91461199
53MAPK signaling pathway_Homo sapiens_hsa040100.91378131
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90455266
55Choline metabolism in cancer_Homo sapiens_hsa052310.89234952
56Non-small cell lung cancer_Homo sapiens_hsa052230.89115337
57Phototransduction_Homo sapiens_hsa047440.87094202
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.86656208
59mTOR signaling pathway_Homo sapiens_hsa041500.85702003
60Oocyte meiosis_Homo sapiens_hsa041140.85326052
61VEGF signaling pathway_Homo sapiens_hsa043700.84509057
62Prion diseases_Homo sapiens_hsa050200.84374477
63Pancreatic secretion_Homo sapiens_hsa049720.81822933
64Hedgehog signaling pathway_Homo sapiens_hsa043400.81631032
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80997760
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80597574
67Thyroid hormone synthesis_Homo sapiens_hsa049180.80424687
68Inositol phosphate metabolism_Homo sapiens_hsa005620.80347922
69Cardiac muscle contraction_Homo sapiens_hsa042600.80133329
70Bile secretion_Homo sapiens_hsa049760.77665101
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74193201
72Rap1 signaling pathway_Homo sapiens_hsa040150.73451520
73Vibrio cholerae infection_Homo sapiens_hsa051100.71170125
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70587072
75Chronic myeloid leukemia_Homo sapiens_hsa052200.70085133
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.69411080
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68332398
78Ras signaling pathway_Homo sapiens_hsa040140.68122124
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67227414
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67145601
81Hippo signaling pathway_Homo sapiens_hsa043900.66738684
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.66549744
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63504807
84Insulin signaling pathway_Homo sapiens_hsa049100.62868684
85Collecting duct acid secretion_Homo sapiens_hsa049660.62606500
86Notch signaling pathway_Homo sapiens_hsa043300.60597804
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60566549
88Renal cell carcinoma_Homo sapiens_hsa052110.59977849
89Dorso-ventral axis formation_Homo sapiens_hsa043200.59757497
90Alcoholism_Homo sapiens_hsa050340.59690691
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59442373
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55961886
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55064107
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53776191
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52090539
96Vitamin B6 metabolism_Homo sapiens_hsa007500.51871787
97Protein digestion and absorption_Homo sapiens_hsa049740.51665970
98Platelet activation_Homo sapiens_hsa046110.51613515
99Melanoma_Homo sapiens_hsa052180.51362020
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49453437
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.49334442
102Prolactin signaling pathway_Homo sapiens_hsa049170.48686148
103Viral myocarditis_Homo sapiens_hsa054160.48599395
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47603798
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46694445
106MicroRNAs in cancer_Homo sapiens_hsa052060.46536898
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45583596
108Pancreatic cancer_Homo sapiens_hsa052120.45208306
109Circadian rhythm_Homo sapiens_hsa047100.45076308
110Glucagon signaling pathway_Homo sapiens_hsa049220.44680061
111Endocytosis_Homo sapiens_hsa041440.44654755
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44090289
113Chemokine signaling pathway_Homo sapiens_hsa040620.44022709
114AMPK signaling pathway_Homo sapiens_hsa041520.43567400
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41490380
116Focal adhesion_Homo sapiens_hsa045100.40527583
117ECM-receptor interaction_Homo sapiens_hsa045120.36391860

Most similar genes based on co-expression Upload to Enrichr

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