MDFI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.22880648
2ribosomal small subunit assembly (GO:0000028)5.57491478
3desmosome organization (GO:0002934)5.47416142
4mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.56714478
5viral transcription (GO:0019083)4.33517143
6cell-substrate junction assembly (GO:0007044)4.28460349
7semaphorin-plexin signaling pathway (GO:0071526)4.17434107
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16613529
9translational termination (GO:0006415)4.12473363
10notochord development (GO:0030903)4.05071545
11convergent extension (GO:0060026)4.00059970
12translational elongation (GO:0006414)3.63933218
13basement membrane organization (GO:0071711)3.63864887
14DNA unwinding involved in DNA replication (GO:0006268)3.61422911
15maturation of SSU-rRNA (GO:0030490)3.50481079
16negative regulation of cartilage development (GO:0061037)3.48755478
17cell-cell junction maintenance (GO:0045217)3.47311569
18endodermal cell differentiation (GO:0035987)3.47275480
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.40331102
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39293273
21apoptotic process involved in morphogenesis (GO:0060561)3.38600060
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34911530
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34325304
24negative regulation of catenin import into nucleus (GO:0035414)3.31787229
25definitive hemopoiesis (GO:0060216)3.28379641
26adherens junction assembly (GO:0034333)3.27128512
27protein targeting to ER (GO:0045047)3.22915136
28viral life cycle (GO:0019058)3.21934300
29cotranslational protein targeting to membrane (GO:0006613)3.21245181
30ribosomal small subunit biogenesis (GO:0042274)3.19702866
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15358049
32paraxial mesoderm development (GO:0048339)3.14978017
33negative regulation of keratinocyte proliferation (GO:0010839)3.13563283
34negative regulation of cell fate specification (GO:0009996)3.13113848
35mesenchymal to epithelial transition (GO:0060231)3.12327460
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11932032
37G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.11246739
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.10954712
39negative regulation of RNA splicing (GO:0033119)3.10824066
40cellular protein complex disassembly (GO:0043624)3.10141942
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06519755
42lateral sprouting from an epithelium (GO:0060601)3.02498658
43establishment or maintenance of apical/basal cell polarity (GO:0035088)3.02282694
44establishment or maintenance of bipolar cell polarity (GO:0061245)3.02282694
45cochlea morphogenesis (GO:0090103)3.02155073
46branching involved in salivary gland morphogenesis (GO:0060445)3.02140812
47translational initiation (GO:0006413)3.00137900
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.00086929
49establishment of monopolar cell polarity (GO:0061162)3.00086929
50protein complex disassembly (GO:0043241)2.99777538
51epithelial cell-cell adhesion (GO:0090136)2.99542159
52outer ear morphogenesis (GO:0042473)2.97812490
53gonadal mesoderm development (GO:0007506)2.95455902
54camera-type eye morphogenesis (GO:0048593)2.93905271
55atrioventricular valve morphogenesis (GO:0003181)2.93885031
56gap junction assembly (GO:0016264)2.93130909
57protein localization to endoplasmic reticulum (GO:0070972)2.92898036
58asymmetric protein localization (GO:0008105)2.92343114
59keratinocyte proliferation (GO:0043616)2.92193462
60activation of Rac GTPase activity (GO:0032863)2.91700428
61apoptotic process involved in development (GO:1902742)2.89906558
62cell junction maintenance (GO:0034331)2.88917747
63anatomical structure regression (GO:0060033)2.87833173
64renal system development (GO:0072001)2.87789591
65neural tube development (GO:0021915)2.85658611
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83644579
67polarized epithelial cell differentiation (GO:0030859)2.82524781
68regulation of heart morphogenesis (GO:2000826)2.82503051
69white fat cell differentiation (GO:0050872)2.82320297
70focal adhesion assembly (GO:0048041)2.81496221
71cell-substrate adherens junction assembly (GO:0007045)2.81496221
72protein retention in ER lumen (GO:0006621)2.80291253
73negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.80195796
74embryonic camera-type eye development (GO:0031076)2.77664648
75embryonic skeletal joint morphogenesis (GO:0060272)2.73955131
76regulation of stem cell maintenance (GO:2000036)2.73158853
77regulation of water loss via skin (GO:0033561)2.71775967
78cell proliferation involved in metanephros development (GO:0072203)2.71325186
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70413895
80macromolecular complex disassembly (GO:0032984)2.70112769
81protein localization to kinetochore (GO:0034501)2.68980628
82lung-associated mesenchyme development (GO:0060484)2.66629202
83collagen metabolic process (GO:0032963)2.66094665
84DNA topological change (GO:0006265)2.65029833
85regulation of cardioblast differentiation (GO:0051890)2.64990861
86T cell apoptotic process (GO:0070231)2.64789826
87nuclear-transcribed mRNA catabolic process (GO:0000956)2.64587763
88collagen catabolic process (GO:0030574)2.64050325
89lens morphogenesis in camera-type eye (GO:0002089)2.63292439
90establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63068718
91establishment of skin barrier (GO:0061436)2.62063328
92establishment of apical/basal cell polarity (GO:0035089)2.61345557
933-UTR-mediated mRNA stabilization (GO:0070935)2.60852781
94regulation of catenin import into nucleus (GO:0035412)2.60724102
95extracellular matrix disassembly (GO:0022617)2.60089789
96regulation of cardioblast proliferation (GO:0003264)2.57968734
97regulation of secondary heart field cardioblast proliferation (GO:0003266)2.57968734
98negative regulation of erythrocyte differentiation (GO:0045647)2.57333297
99muscle cell migration (GO:0014812)2.57212157
100cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56918647
101adherens junction organization (GO:0034332)2.56879479
102endothelial cell morphogenesis (GO:0001886)2.56608666
103cell junction assembly (GO:0034329)2.56299537
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55447972
105mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55447972
106mesenchymal-epithelial cell signaling (GO:0060638)2.55378349
107respiratory tube development (GO:0030323)2.54761905
108digestive tract morphogenesis (GO:0048546)2.54195397
109skin development (GO:0043588)2.54039453
110collagen fibril organization (GO:0030199)2.53303140
111negative regulation of mRNA processing (GO:0050686)2.53133179
112mRNA catabolic process (GO:0006402)2.52955032
113establishment of epithelial cell polarity (GO:0090162)2.52892619
114alternative mRNA splicing, via spliceosome (GO:0000380)2.51577962
115histone H2A monoubiquitination (GO:0035518)2.51105988
116embryonic foregut morphogenesis (GO:0048617)2.51009177
117apical protein localization (GO:0045176)2.50715936
118regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49840731
119urogenital system development (GO:0001655)2.49633895
120multicellular organismal macromolecule metabolic process (GO:0044259)2.49415322
121heart valve formation (GO:0003188)2.49276171
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49218035
123proximal/distal pattern formation (GO:0009954)2.49208653
124cell surface receptor signaling pathway involved in heart development (GO:0061311)2.49080699
125non-canonical Wnt signaling pathway (GO:0035567)2.48699868
126surfactant homeostasis (GO:0043129)2.48559583
127negative regulation of epidermis development (GO:0045683)2.46415560
128keratinization (GO:0031424)2.44777975
129RNA catabolic process (GO:0006401)2.44391445
130cell junction organization (GO:0034330)2.44281962
131heterochromatin organization (GO:0070828)2.44132721
132cell aggregation (GO:0098743)2.43696498
133cartilage condensation (GO:0001502)2.43696498
134pattern specification involved in kidney development (GO:0061004)2.43610945
135glial cell migration (GO:0008347)2.43517469
136positive regulation of hormone biosynthetic process (GO:0046886)2.43161241
137regulation of transforming growth factor beta2 production (GO:0032909)2.43085791
138regulation of sister chromatid cohesion (GO:0007063)2.43043962
139vascular endothelial growth factor signaling pathway (GO:0038084)2.42736257
140epidermis development (GO:0008544)2.41854133
141eye morphogenesis (GO:0048592)2.41827654
142regulation of hair follicle development (GO:0051797)2.39871187
143regulation of establishment of planar polarity (GO:0090175)2.38956319
144hippo signaling (GO:0035329)2.38810070
145cell migration involved in heart development (GO:0060973)2.38739198
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37333066
147multicellular organismal catabolic process (GO:0044243)2.37247066
148regulation of cell fate specification (GO:0042659)2.35940655
149retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35830020
150dosage compensation (GO:0007549)2.35784418
151positive regulation of epithelial to mesenchymal transition (GO:0010718)2.35686548
152morphogenesis of an endothelium (GO:0003159)2.35432161
153endothelial tube morphogenesis (GO:0061154)2.35432161
154ribosomal large subunit biogenesis (GO:0042273)2.35194135
155IMP biosynthetic process (GO:0006188)2.34462102
156positive regulation of DNA-dependent DNA replication (GO:2000105)2.34363023
157protein heterotrimerization (GO:0070208)2.34062666
158axon extension involved in axon guidance (GO:0048846)2.32865862
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.32865862
160bone trabecula formation (GO:0060346)2.32214587
161protein-DNA complex disassembly (GO:0032986)2.31145982
162nucleosome disassembly (GO:0006337)2.31145982
163negative regulation of DNA repair (GO:0045738)2.27996648
164DNA integration (GO:0015074)2.25567665
165lymphocyte apoptotic process (GO:0070227)2.24629903
166somatic stem cell division (GO:0048103)2.24319566
167positive regulation of SMAD protein import into nucleus (GO:0060391)2.23870925
168face development (GO:0060324)2.23462935
169negative regulation of chondrocyte differentiation (GO:0032331)2.23395337
170regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.22588230
171establishment of tissue polarity (GO:0007164)2.22134423
172establishment of planar polarity (GO:0001736)2.22134423
173DNA strand elongation involved in DNA replication (GO:0006271)2.21784392
174mesenchyme morphogenesis (GO:0072132)2.19586465
175peptidyl-arginine omega-N-methylation (GO:0035247)2.19548861
176embryonic eye morphogenesis (GO:0048048)2.18835998
177megakaryocyte development (GO:0035855)2.17073673
178blood vessel maturation (GO:0001955)2.16731086
179DNA strand elongation (GO:0022616)2.15600382
180negative regulation of embryonic development (GO:0045992)2.15380679
181formation of translation preinitiation complex (GO:0001731)2.14936069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42753424
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.49213476
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.12738075
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.55390897
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.41546876
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98492682
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82953706
8MYC_22102868_ChIP-Seq_BL_Human2.71951171
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67815717
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.63715350
11SCL_19346495_ChIP-Seq_HPC-7_Human2.62004658
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52824519
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.44118524
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41473977
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26126825
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26011654
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16278727
18* LXR_22292898_ChIP-Seq_THP-1_Human2.14842238
19ZNF263_19887448_ChIP-Seq_K562_Human2.07014337
20CLOCK_20551151_ChIP-Seq_293T_Human1.98225236
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97147096
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96144534
23KDM2B_26808549_Chip-Seq_K562_Human1.90685782
24UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.90629025
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89087776
26VDR_21846776_ChIP-Seq_THP-1_Human1.87515154
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.86075370
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85441529
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84887471
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83621973
31XRN2_22483619_ChIP-Seq_HELA_Human1.83443827
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81500662
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80734656
34TCF7_22412390_ChIP-Seq_EML_Mouse1.77138203
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.76989153
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73687336
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72766935
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71821853
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71683964
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70515253
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68497167
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.68475274
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66891075
44AR_21909140_ChIP-Seq_LNCAP_Human1.64279142
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60053157
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58919713
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55972774
48CIITA_25753668_ChIP-Seq_RAJI_Human1.54626206
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52652192
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50000608
51CTCF_27219007_Chip-Seq_Bcells_Human1.48591017
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48247630
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47561117
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46914116
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41866024
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41221478
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41220047
58TP53_22127205_ChIP-Seq_IMR90_Human1.41180283
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40696153
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.40334388
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39108825
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37496538
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37183159
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36744171
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36486449
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36486449
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35959340
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35314053
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.34987286
70VDR_24763502_ChIP-Seq_THP-1_Human1.34985043
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30539322
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27412597
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.27060190
74TTF2_22483619_ChIP-Seq_HELA_Human1.26063883
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24811725
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24191604
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23758123
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22279340
79MAF_26560356_Chip-Seq_TH1_Human1.21745982
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21313508
81SMC4_20622854_ChIP-Seq_HELA_Human1.20655557
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19741899
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19519422
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19498165
85* RNF2_27304074_Chip-Seq_ESCs_Mouse1.19162983
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18808806
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18494432
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18092159
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.17977214
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17809909
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16891496
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16729070
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16545440
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14688246
95* TET1_21490601_ChIP-Seq_MESCs_Mouse1.14584952
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13743179
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.13726098
98* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13213022
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12366126
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.11990978
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.11801234
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.11565599
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11490092
104UTX_26944678_Chip-Seq_JUKART_Human1.11484985
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11449446
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.11394459
107* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10754017
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10594908
109* TP63_22573176_ChIP-Seq_HFKS_Human1.10586852
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10085979
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10085979
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10085979
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09944499
114* ATF3_27146783_Chip-Seq_COLON_Human1.09887176
115EZH2_27304074_Chip-Seq_ESCs_Mouse1.09416495
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09126273
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.08158081
118CREB1_26743006_Chip-Seq_LNCaP_Human1.07777399
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07081602
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05889233
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.05868123
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05474311
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05328805
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05285952
125* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05174582
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05007686
127P68_20966046_ChIP-Seq_HELA_Human1.04810392
128RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04663886
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.03081203
130CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02791068
131SPI1_23547873_ChIP-Seq_NB4_Human1.02730127
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02518182
133TP53_23651856_ChIP-Seq_MEFs_Mouse1.01353649
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00836109
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99918527
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99775377
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99633795
138KDM2B_26808549_Chip-Seq_DND41_Human0.99422469
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99029020
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98840338
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.98507852
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.98507852
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97780135
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97600481
145FOXP3_21729870_ChIP-Seq_TREG_Human0.97135629
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96995920
147NCOR1_26117541_ChIP-Seq_K562_Human0.96957641
148* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96431569
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96308642
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95321942
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.95214549
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94933505
153* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92826063
154* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92826063
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91804822
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91538556
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90740823
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90420483
159RUNX1_22412390_ChIP-Seq_EML_Mouse0.90358676
160RACK7_27058665_Chip-Seq_MCF-7_Human0.89536917
161IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89310053
162SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89211407
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88405215
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87928190
165FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85582755
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85200016
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84954952
168MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84306590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting2.68213763
2MP0006054_spinal_hemorrhage2.56746210
3MP0003941_abnormal_skin_development2.50287467
4MP0005409_darkened_coat_color2.41679614
5MP0010030_abnormal_orbit_morphology2.28476107
6MP0002396_abnormal_hematopoietic_system2.24390095
7MP0002796_impaired_skin_barrier2.21730826
8MP0009053_abnormal_anal_canal2.17840129
9MP0005257_abnormal_intraocular_pressure2.16998254
10MP0000537_abnormal_urethra_morphology2.12332751
11MP0000467_abnormal_esophagus_morphology2.10541551
12MP0004272_abnormal_basement_membrane2.05623552
13MP0003122_maternal_imprinting2.03494010
14MP0004858_abnormal_nervous_system2.03051525
15MP0002060_abnormal_skin_morphology1.96354313
16MP0009278_abnormal_bone_marrow1.94582872
17MP0008007_abnormal_cellular_replicative1.89977467
18MP0004808_abnormal_hematopoietic_stem1.88851119
19MP0003705_abnormal_hypodermis_morpholog1.88668922
20MP0003453_abnormal_keratinocyte_physiol1.82711528
21MP0003121_genomic_imprinting1.81632008
22MP0003567_abnormal_fetal_cardiomyocyte1.81531425
23MP0002938_white_spotting1.79785798
24MP0005171_absent_coat_pigmentation1.78265525
25MP0005503_abnormal_tendon_morphology1.72502863
26MP0002249_abnormal_larynx_morphology1.68800526
27MP0009379_abnormal_foot_pigmentation1.67282975
28MP0010094_abnormal_chromosome_stability1.67046815
29MP0003385_abnormal_body_wall1.64161281
30MP0002697_abnormal_eye_size1.62542937
31MP0005670_abnormal_white_adipose1.62243103
32MP0003136_yellow_coat_color1.61303102
33MP0003942_abnormal_urinary_system1.57754773
34MP0010368_abnormal_lymphatic_system1.54529780
35MP0002282_abnormal_trachea_morphology1.54407140
36MP0003566_abnormal_cell_adhesion1.53338110
37MP0005377_hearing/vestibular/ear_phenot1.52851536
38MP0003878_abnormal_ear_physiology1.52851536
39MP0002932_abnormal_joint_morphology1.52668742
40MP0005501_abnormal_skin_physiology1.52621391
41MP0001545_abnormal_hematopoietic_system1.52160410
42MP0005397_hematopoietic_system_phenotyp1.52160410
43MP0000372_irregular_coat_pigmentation1.50815703
44MP0003111_abnormal_nucleus_morphology1.49878596
45MP0000566_synostosis1.49168973
46MP0003693_abnormal_embryo_hatching1.48930451
47MP0003077_abnormal_cell_cycle1.47401877
48MP0000049_abnormal_middle_ear1.44133917
49MP0001299_abnormal_eye_distance/1.42706505
50MP0001216_abnormal_epidermal_layer1.41064320
51MP0004957_abnormal_blastocyst_morpholog1.40823660
52MP0010234_abnormal_vibrissa_follicle1.39617222
53MP0000762_abnormal_tongue_morphology1.37836899
54MP0005666_abnormal_adipose_tissue1.37058010
55MP0000377_abnormal_hair_follicle1.36882313
56MP0001293_anophthalmia1.35197823
57MP0002095_abnormal_skin_pigmentation1.34912108
58MP0005075_abnormal_melanosome_morpholog1.32847432
59MP0003115_abnormal_respiratory_system1.31998335
60MP0004197_abnormal_fetal_growth/weight/1.31192930
61MP0005508_abnormal_skeleton_morphology1.26995831
62MP0003935_abnormal_craniofacial_develop1.26505658
63MP0000383_abnormal_hair_follicle1.26365131
64MP0004185_abnormal_adipocyte_glucose1.26098145
65MP0000490_abnormal_crypts_of1.25681031
66MP0002233_abnormal_nose_morphology1.24078045
67MP0000733_abnormal_muscle_development1.22581781
68MP0009250_abnormal_appendicular_skeleto1.22309363
69MP0001849_ear_inflammation1.21546033
70MP0006138_congestive_heart_failure1.19097541
71MP0005375_adipose_tissue_phenotype1.18129870
72MP0000678_abnormal_parathyroid_gland1.17240134
73MP0003937_abnormal_limbs/digits/tail_de1.16226516
74MP0010771_integument_phenotype1.14181892
75MP0000428_abnormal_craniofacial_morphol1.13833736
76MP0003279_aneurysm1.13281670
77MP0008438_abnormal_cutaneous_collagen1.11587011
78MP0005174_abnormal_tail_pigmentation1.11208099
79MP0003943_abnormal_hepatobiliary_system1.10806890
80MP0000534_abnormal_ureter_morphology1.09963514
81MP0000465_gastrointestinal_hemorrhage1.09916321
82MP0002109_abnormal_limb_morphology1.09272274
83MP0002098_abnormal_vibrissa_morphology1.07355636
84MP0005076_abnormal_cell_differentiation1.06350079
85MP0000003_abnormal_adipose_tissue1.06161808
86MP0000350_abnormal_cell_proliferation1.05854139
87* MP0002085_abnormal_embryonic_tissue1.05794265
88MP0001915_intracranial_hemorrhage1.05586725
89MP0003315_abnormal_perineum_morphology1.04885637
90MP0005248_abnormal_Harderian_gland1.04511304
91* MP0002086_abnormal_extraembryonic_tissu1.04466477
92MP0010678_abnormal_skin_adnexa1.03990888
93MP0003755_abnormal_palate_morphology1.03724540
94MP0005275_abnormal_skin_tensile1.03118700
95MP0008932_abnormal_embryonic_tissue1.03060808
96MP0005023_abnormal_wound_healing1.02267513
97MP0003119_abnormal_digestive_system1.02089582
98MP0002234_abnormal_pharynx_morphology1.01404512
99MP0001286_abnormal_eye_development1.01365280
100MP0001340_abnormal_eyelid_morphology1.00022309
101MP0010352_gastrointestinal_tract_polyps0.99871775
102MP0004264_abnormal_extraembryonic_tissu0.98689170
103MP0004381_abnormal_hair_follicle0.97560224
104MP0005367_renal/urinary_system_phenotyp0.97130546
105MP0000516_abnormal_urinary_system0.97130546
106MP0002092_abnormal_eye_morphology0.97102303
107MP0005623_abnormal_meninges_morphology0.96264078
108* MP0002084_abnormal_developmental_patter0.95966145
109MP0008789_abnormal_olfactory_epithelium0.95207428
110MP0000163_abnormal_cartilage_morphology0.95071196
111MP0000462_abnormal_digestive_system0.94161786
112MP0002116_abnormal_craniofacial_bone0.94037071
113MP0002925_abnormal_cardiovascular_devel0.93713989
114* MP0001672_abnormal_embryogenesis/_devel0.93511787
115* MP0005380_embryogenesis_phenotype0.93511787
116MP0009672_abnormal_birth_weight0.93348550
117MP0000432_abnormal_head_morphology0.92859140
118* MP0002111_abnormal_tail_morphology0.92673116
119MP0003091_abnormal_cell_migration0.92068372
120MP0001697_abnormal_embryo_size0.91051576
121MP0004134_abnormal_chest_morphology0.90652291
122MP0006292_abnormal_olfactory_placode0.90327440
123MP0002075_abnormal_coat/hair_pigmentati0.89925985
124MP0000767_abnormal_smooth_muscle0.89260867
125MP0001879_abnormal_lymphatic_vessel0.89225758
126* MP0003984_embryonic_growth_retardation0.88982303
127MP0000579_abnormal_nail_morphology0.88111572
128* MP0002113_abnormal_skeleton_development0.87702665
129MP0001270_distended_abdomen0.87676059
130* MP0002088_abnormal_embryonic_growth/wei0.87517605
131MP0002089_abnormal_postnatal_growth/wei0.85246514
132MP0000778_abnormal_nervous_system0.85050574
133MP0000371_diluted_coat_color0.84772880
134MP0000751_myopathy0.84601926
135MP0002254_reproductive_system_inflammat0.81667907
136MP0003283_abnormal_digestive_organ0.81327254
137MP0010630_abnormal_cardiac_muscle0.80562756
138MP0009384_cardiac_valve_regurgitation0.79758984
139* MP0003861_abnormal_nervous_system0.79149798
140MP0005193_abnormal_anterior_eye0.78150049
141MP0005499_abnormal_olfactory_system0.76432993
142MP0005394_taste/olfaction_phenotype0.76432993

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)4.21485644
2Protrusio acetabuli (HP:0003179)3.92993890
3Asymmetry of the thorax (HP:0001555)3.54364103
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37078703
5Short 4th metacarpal (HP:0010044)3.37078703
6Pterygium (HP:0001059)3.20908696
7Renal duplication (HP:0000075)3.14652690
8Plantar hyperkeratosis (HP:0007556)3.04593945
9Aplastic anemia (HP:0001915)2.96060524
10Onycholysis (HP:0001806)2.95903662
11Right ventricular cardiomyopathy (HP:0011663)2.90365976
12Vertebral clefting (HP:0008428)2.90172936
13Alopecia of scalp (HP:0002293)2.83529239
14Selective tooth agenesis (HP:0001592)2.81129571
15Hyperacusis (HP:0010780)2.77365362
16Epiphyseal dysplasia (HP:0002656)2.70342161
17Shallow orbits (HP:0000586)2.69834585
18Abnormality of the 4th metacarpal (HP:0010012)2.68672525
19Thick nail (HP:0001805)2.65250422
20Abnormality of the parietal bone (HP:0002696)2.63410640
21Reticulocytopenia (HP:0001896)2.62666717
22Hypoplastic ischia (HP:0003175)2.57463074
23Abnormality of the ischium (HP:0003174)2.57241419
24Flat acetabular roof (HP:0003180)2.49306771
25Aplasia cutis congenita (HP:0001057)2.45791083
26Coronal craniosynostosis (HP:0004440)2.45491782
27Advanced eruption of teeth (HP:0006288)2.44287884
28Ankle contracture (HP:0006466)2.43864999
29Thrombocytosis (HP:0001894)2.40743005
30Midline defect of the nose (HP:0004122)2.37368390
31Thin ribs (HP:0000883)2.37253325
32Colon cancer (HP:0003003)2.33811156
33Natal tooth (HP:0000695)2.32492343
34Increased nuchal translucency (HP:0010880)2.28645362
35Turricephaly (HP:0000262)2.27590704
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27374599
37Absent epiphyses (HP:0010577)2.27374599
38Metaphyseal cupping (HP:0003021)2.26030405
39Mesomelia (HP:0003027)2.25862154
40Ridged nail (HP:0001807)2.24703896
41Disproportionate tall stature (HP:0001519)2.22089003
42Pili torti (HP:0003777)2.21768933
43Nail dystrophy (HP:0008404)2.20396762
44Cerebral aneurysm (HP:0004944)2.18979747
45Abnormality of the calcaneus (HP:0008364)2.18954723
46Abnormal vertebral ossification (HP:0100569)2.14077070
47Broad palm (HP:0001169)2.12653375
48Neonatal short-limb short stature (HP:0008921)2.12191561
49Renovascular hypertension (HP:0100817)2.11874583
50Medulloblastoma (HP:0002885)2.10194764
51Palmoplantar hyperkeratosis (HP:0000972)2.07670607
52Sprengel anomaly (HP:0000912)2.06970437
53Premature rupture of membranes (HP:0001788)2.04930057
54Short 5th finger (HP:0009237)2.03307690
55Flat cornea (HP:0007720)2.03297074
56Ankyloglossia (HP:0010296)2.01498155
57Morphological abnormality of the middle ear (HP:0008609)1.98556177
58Nephroblastoma (Wilms tumor) (HP:0002667)1.98514487
59Abnormality of the fingertips (HP:0001211)1.97554559
60Bronchomalacia (HP:0002780)1.97454225
61High anterior hairline (HP:0009890)1.97267574
62Atrophic scars (HP:0001075)1.96889688
63Bladder diverticulum (HP:0000015)1.96780053
64Genu recurvatum (HP:0002816)1.95944209
65Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94527129
66Palmar hyperkeratosis (HP:0010765)1.93896835
67Elfin facies (HP:0004428)1.93669129
68Milia (HP:0001056)1.92925760
69Short middle phalanx of the 5th finger (HP:0004220)1.91816982
70Embryonal renal neoplasm (HP:0011794)1.91597161
71Mixed hearing impairment (HP:0000410)1.91071588
72Syringomyelia (HP:0003396)1.90687623
73Spinal cord lesions (HP:0100561)1.90687623
74Abnormal number of incisors (HP:0011064)1.90474160
75Abnormality of dentin (HP:0010299)1.90354351
76Radial bowing (HP:0002986)1.89176995
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88405209
78Deviation of the hallux (HP:0010051)1.87527021
79Abnormality of the salivary glands (HP:0010286)1.87083194
80Lymphangioma (HP:0100764)1.87081699
81Subacute progressive viral hepatitis (HP:0006572)1.87068449
82Mitral valve prolapse (HP:0001634)1.85767893
83Slender long bone (HP:0003100)1.85381227
84Overriding aorta (HP:0002623)1.85203969
85Flattened epiphyses (HP:0003071)1.84863965
86Broad thumb (HP:0011304)1.84198040
87Aplasia involving bones of the upper limbs (HP:0009823)1.83904011
88Aplasia of the phalanges of the hand (HP:0009802)1.83904011
89Aplasia involving bones of the extremities (HP:0009825)1.83904011
90Obstructive sleep apnea (HP:0002870)1.83673867
91Abnormality of cells of the erythroid lineage (HP:0012130)1.83419369
92Anonychia (HP:0001798)1.82921369
93Hypotrichosis (HP:0001006)1.82608351
94Vitreoretinal degeneration (HP:0000655)1.82259724
95Arnold-Chiari malformation (HP:0002308)1.81287253
96Supernumerary ribs (HP:0005815)1.80801610
97Germ cell neoplasia (HP:0100728)1.79889104
98Cervical subluxation (HP:0003308)1.79178645
99Fragile skin (HP:0001030)1.78764650
100Long palpebral fissure (HP:0000637)1.78590241
101Hallux valgus (HP:0001822)1.77870050
102Blue sclerae (HP:0000592)1.76640432
103Vertebral arch anomaly (HP:0008438)1.76293427
104Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75649143
105Flared metaphyses (HP:0003015)1.75259320
106Cutaneous syndactyly (HP:0012725)1.74999407
107Aortic aneurysm (HP:0004942)1.74909556
108Heterochromia iridis (HP:0001100)1.74832039
109Esophageal atresia (HP:0002032)1.74416214
110Supernumerary bones of the axial skeleton (HP:0009144)1.74305266
111Absent eyelashes (HP:0000561)1.74039550
112Exostoses (HP:0100777)1.73917795
113Mild short stature (HP:0003502)1.73262720
114Cutaneous finger syndactyly (HP:0010554)1.72647508
115Short nail (HP:0001799)1.72482698
116Aortic dissection (HP:0002647)1.72451582
117Delayed epiphyseal ossification (HP:0002663)1.71575451
118Sparse scalp hair (HP:0002209)1.70888947
119Bell-shaped thorax (HP:0001591)1.70521956
120Skull defect (HP:0001362)1.70074748
121Irregular epiphyses (HP:0010582)1.69990108
122Cupped ribs (HP:0000887)1.69784161
123Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69164709
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.68996023
125Abnormal number of erythroid precursors (HP:0012131)1.68882042
126Lumbar hyperlordosis (HP:0002938)1.68827972
127Spinal rigidity (HP:0003306)1.68399907
128Partial duplication of the phalanx of hand (HP:0009999)1.67579196
129Midface retrusion (HP:0011800)1.67396979
130Thin bony cortex (HP:0002753)1.67319508
131High pitched voice (HP:0001620)1.67279628
132Broad phalanges of the hand (HP:0009768)1.66598559
133Partial duplication of thumb phalanx (HP:0009944)1.66344670
134Tracheomalacia (HP:0002779)1.66035255
135Synostosis of carpal bones (HP:0005048)1.66012154
136Laryngomalacia (HP:0001601)1.65865338
137Broad face (HP:0000283)1.65429578
138Carpal synostosis (HP:0009702)1.64630243
139Amaurosis fugax (HP:0100576)1.64628582
140Arterial tortuosity (HP:0005116)1.64473952
141Limited hip movement (HP:0008800)1.63264656
142Skin tags (HP:0010609)1.62895058
143Abnormality of the neuromuscular junction (HP:0003398)1.61736969
144Fatigable weakness (HP:0003473)1.61736969
145Abnormal lung lobation (HP:0002101)1.61483577
146Broad long bones (HP:0005622)1.61303653
147Atresia of the external auditory canal (HP:0000413)1.60190417
148Bowel diverticulosis (HP:0005222)1.59866098
149Abnormality of the phalanges of the 5th finger (HP:0004213)1.59406275
150Down-sloping shoulders (HP:0200021)1.57685853
151Chromsome breakage (HP:0040012)1.57560944
152Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57012814
153Broad phalanx (HP:0006009)1.55588355
154Abnormality of nail color (HP:0100643)1.53923862
155Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52669995
156Abnormality of the intervertebral disk (HP:0005108)1.52367673
157Broad finger (HP:0001500)1.52176140
158Broad metatarsal (HP:0001783)1.52050709
159Bowed forearm bones (HP:0003956)1.51869738
160Bowing of the arm (HP:0006488)1.51869738
16111 pairs of ribs (HP:0000878)1.51493535
162Myelodysplasia (HP:0002863)1.50518007
163Shawl scrotum (HP:0000049)1.49933983
164Ulnar bowing (HP:0003031)1.49143107
165White forelock (HP:0002211)1.46200803
166Enlarged penis (HP:0000040)1.46150587
167Long eyelashes (HP:0000527)1.45650543
168Hematochezia (HP:0002573)1.45625946
169Abnormality of the phalanges of the hallux (HP:0010057)1.45434732
170Preauricular skin tag (HP:0000384)1.45067242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.31802931
2PKN24.27666539
3TGFBR13.10985770
4NTRK12.98583700
5RPS6KB22.88957854
6FLT32.87635447
7TRIB32.83578620
8DDR22.57538481
9MAP3K102.45104731
10LATS12.22239195
11TIE12.21907499
12SMG12.19325935
13PAK42.06729954
14TYRO32.04831989
15MAPK151.98927278
16BUB11.98548680
17PASK1.96419143
18PTK61.91679955
19WEE11.86393210
20MKNK11.76666149
21TSSK61.71173352
22FGFR41.68298148
23LMTK21.62740656
24CDK81.62466477
25NEK21.61905433
26MAP3K61.58090126
27ICK1.55129540
28CDK71.53841506
29TGFBR21.48558767
30BTK1.46092787
31ARAF1.44732543
32PRKD31.39224262
33ACVR1B1.38954406
34EPHA21.37307738
35DYRK31.36221102
36EPHB21.35093828
37RIPK11.32423636
38MAP2K31.30376204
39CDK41.30045256
40EPHA31.23282074
41MATK1.21086311
42STK31.20312243
43CDK61.18458703
44LRRK21.17354157
45MAP3K91.16701946
46NEK91.13416173
47RPS6KA41.12616201
48PDGFRA1.11627262
49MKNK21.10130035
50KIT1.10011611
51STK241.09710403
52PDGFRB1.08881880
53MOS1.07623189
54FGFR21.05308994
55CSF1R1.01319726
56CAMK1D0.97373363
57ILK0.95889904
58TESK10.95658760
59ERBB30.95143177
60RPS6KA20.94661350
61MARK20.93548958
62CDC70.93385935
63SIK10.91054861
64BMX0.90339255
65ATR0.89018227
66SRPK10.88940955
67PAK20.87869160
68MAPKAPK30.86170509
69DMPK0.85956533
70NME20.85130167
71CDC42BPA0.84811469
72CLK10.84397708
73MAP3K80.84055679
74MET0.82026542
75KDR0.81187450
76EPHB10.78185782
77STK38L0.77451896
78TEC0.75996421
79BRAF0.74556200
80AURKB0.74273831
81TRPM70.73882281
82MAP3K30.73038004
83PIM10.71580426
84TTK0.71074140
85ROCK20.70943933
86NME10.70811671
87STK40.68052040
88ERN10.67262073
89PRKG20.67229867
90PIM20.66685181
91ALK0.66152049
92JAK30.66033865
93FGFR10.65662020
94TTN0.65407065
95NEK10.64722024
96CAMK1G0.64525999
97VRK10.61676933
98PRKD20.61009327
99YES10.60778353
100RPS6KL10.60660619
101RPS6KC10.60660619
102RPS6KA60.60034596
103MAP4K10.58950337
104AKT20.58862854
105TNIK0.58703807
106CHUK0.58535813
107LATS20.58447546
108MAP3K110.56681388
109PTK20.55756210
110RET0.51746677
111KSR20.51319086
112NTRK20.51132004
113MAP3K70.50399739
114STK100.48568274
115ROCK10.48442778
116MTOR0.47672631
117ZAP700.46543567
118NLK0.45111122
119PLK10.45085017
120MST1R0.43704976
121MAPKAPK20.43240393
122CDK11A0.42952106
123CDK90.42720191
124TAOK20.42361752
125CDK120.40633105
126CDK150.40130074
127FER0.39501145
128ERBB20.38169436
129MAP2K60.38034642
130AKT10.37932301
131BRD40.37820303
132TBK10.37739635
133CHEK10.37367481
134CDK190.36405560
135PRKCI0.34701295
136CDK180.34536868
137MUSK0.34091477
138SRC0.33912677
139MAPK90.31595067
140RPS6KA10.31177121
141SGK30.30920392
142STK380.30462658
143ERBB40.28437356
144MAP3K130.28324830
145MAPK100.27132818
146MAP2K20.26371229
147GSK3A0.26180522
148PRKAA20.25107301
149CDK140.24724170
150DAPK30.24679597
151ABL20.24613689
152MAP3K20.24299335

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.14434771
2DNA replication_Homo sapiens_hsa030303.13021163
3Basal cell carcinoma_Homo sapiens_hsa052172.64549952
4Mismatch repair_Homo sapiens_hsa034302.56956286
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.36665878
6Spliceosome_Homo sapiens_hsa030402.35978628
7Base excision repair_Homo sapiens_hsa034102.26819898
8Cell cycle_Homo sapiens_hsa041102.05650697
9Axon guidance_Homo sapiens_hsa043602.03702354
10ECM-receptor interaction_Homo sapiens_hsa045121.99726295
11Homologous recombination_Homo sapiens_hsa034401.92806285
12Hippo signaling pathway_Homo sapiens_hsa043901.80251352
13Hedgehog signaling pathway_Homo sapiens_hsa043401.76560339
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61755423
15Notch signaling pathway_Homo sapiens_hsa043301.60708463
16One carbon pool by folate_Homo sapiens_hsa006701.59222107
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58778115
18Nucleotide excision repair_Homo sapiens_hsa034201.57686147
19Small cell lung cancer_Homo sapiens_hsa052221.56785132
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53668625
21Fanconi anemia pathway_Homo sapiens_hsa034601.52485564
22RNA transport_Homo sapiens_hsa030131.48369325
23Thyroid cancer_Homo sapiens_hsa052161.46377068
24Chronic myeloid leukemia_Homo sapiens_hsa052201.46023653
25HTLV-I infection_Homo sapiens_hsa051661.40890728
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38392014
27Proteoglycans in cancer_Homo sapiens_hsa052051.36561693
28p53 signaling pathway_Homo sapiens_hsa041151.33918121
29MicroRNAs in cancer_Homo sapiens_hsa052061.33470287
30Adherens junction_Homo sapiens_hsa045201.32820630
31ErbB signaling pathway_Homo sapiens_hsa040121.32546450
32TGF-beta signaling pathway_Homo sapiens_hsa043501.30476345
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30239890
34Focal adhesion_Homo sapiens_hsa045101.30230468
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27035545
36VEGF signaling pathway_Homo sapiens_hsa043701.26372993
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24484621
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24285880
39Herpes simplex infection_Homo sapiens_hsa051681.23026202
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23014900
41Dilated cardiomyopathy_Homo sapiens_hsa054141.22514483
42RNA degradation_Homo sapiens_hsa030181.21120654
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20322327
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19040907
45Glioma_Homo sapiens_hsa052141.16644395
46Colorectal cancer_Homo sapiens_hsa052101.16408506
47Viral carcinogenesis_Homo sapiens_hsa052031.16390702
48Pathways in cancer_Homo sapiens_hsa052001.15017844
49Wnt signaling pathway_Homo sapiens_hsa043101.14435998
50Protein digestion and absorption_Homo sapiens_hsa049741.12327022
51Insulin signaling pathway_Homo sapiens_hsa049101.11994531
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11102094
53Acute myeloid leukemia_Homo sapiens_hsa052211.06814295
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06560245
55Antigen processing and presentation_Homo sapiens_hsa046121.03603103
56Basal transcription factors_Homo sapiens_hsa030221.02068759
57Bladder cancer_Homo sapiens_hsa052191.01783910
58Hepatitis B_Homo sapiens_hsa051610.99329598
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99154149
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98702504
61N-Glycan biosynthesis_Homo sapiens_hsa005100.97604895
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.97134443
63Non-homologous end-joining_Homo sapiens_hsa034500.96939393
64AMPK signaling pathway_Homo sapiens_hsa041520.96791084
65mRNA surveillance pathway_Homo sapiens_hsa030150.96401675
66Prion diseases_Homo sapiens_hsa050200.95289937
67Toxoplasmosis_Homo sapiens_hsa051450.95149521
68Melanogenesis_Homo sapiens_hsa049160.94334397
69Pyrimidine metabolism_Homo sapiens_hsa002400.94277501
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.94224425
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93880274
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93353220
73Leishmaniasis_Homo sapiens_hsa051400.90079410
74PPAR signaling pathway_Homo sapiens_hsa033200.88529134
75Legionellosis_Homo sapiens_hsa051340.87441404
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86445902
77Shigellosis_Homo sapiens_hsa051310.85658012
78Biosynthesis of amino acids_Homo sapiens_hsa012300.83516307
79Pancreatic cancer_Homo sapiens_hsa052120.83425898
80Steroid biosynthesis_Homo sapiens_hsa001000.82638868
81Renal cell carcinoma_Homo sapiens_hsa052110.81938846
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.81686501
83Endometrial cancer_Homo sapiens_hsa052130.81272191
84Measles_Homo sapiens_hsa051620.80607926
85Platelet activation_Homo sapiens_hsa046110.79659996
86Epstein-Barr virus infection_Homo sapiens_hsa051690.79181535
87Systemic lupus erythematosus_Homo sapiens_hsa053220.77983186
88RNA polymerase_Homo sapiens_hsa030200.77916901
89Apoptosis_Homo sapiens_hsa042100.77562938
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76120142
91Melanoma_Homo sapiens_hsa052180.75705078
92Estrogen signaling pathway_Homo sapiens_hsa049150.75294262
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75170161
94GnRH signaling pathway_Homo sapiens_hsa049120.73397468
95Fatty acid biosynthesis_Homo sapiens_hsa000610.73092566
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72375864
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72167428
98Glycerolipid metabolism_Homo sapiens_hsa005610.71959949
99Non-small cell lung cancer_Homo sapiens_hsa052230.71841307
100TNF signaling pathway_Homo sapiens_hsa046680.71754771
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.71001727
102Choline metabolism in cancer_Homo sapiens_hsa052310.70987523
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.70278349
104Sulfur relay system_Homo sapiens_hsa041220.69609561
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69344017
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67997860
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.66571471
108Prostate cancer_Homo sapiens_hsa052150.65948025
109Gap junction_Homo sapiens_hsa045400.65926713
110Ras signaling pathway_Homo sapiens_hsa040140.64183276
111Galactose metabolism_Homo sapiens_hsa000520.63497247
112Hematopoietic cell lineage_Homo sapiens_hsa046400.63205261
113Fatty acid metabolism_Homo sapiens_hsa012120.62650559
114Proteasome_Homo sapiens_hsa030500.62455279
115Influenza A_Homo sapiens_hsa051640.61493514
116Amoebiasis_Homo sapiens_hsa051460.61405659
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61381186
118Malaria_Homo sapiens_hsa051440.61120667
119Phenylalanine metabolism_Homo sapiens_hsa003600.61012491
120HIF-1 signaling pathway_Homo sapiens_hsa040660.60872381
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60211428
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60111333
123Lysine degradation_Homo sapiens_hsa003100.59815153
124Primary immunodeficiency_Homo sapiens_hsa053400.59765224
125Tight junction_Homo sapiens_hsa045300.59206841
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.58902592
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58795511
128Rap1 signaling pathway_Homo sapiens_hsa040150.58425117
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57939147
130B cell receptor signaling pathway_Homo sapiens_hsa046620.57572432
131Viral myocarditis_Homo sapiens_hsa054160.55240895
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.54758392
133Glucagon signaling pathway_Homo sapiens_hsa049220.52852328
134Pentose phosphate pathway_Homo sapiens_hsa000300.51318811
135FoxO signaling pathway_Homo sapiens_hsa040680.50429605
136Inositol phosphate metabolism_Homo sapiens_hsa005620.49569113
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48722177
138Arginine biosynthesis_Homo sapiens_hsa002200.47699767
139Vitamin B6 metabolism_Homo sapiens_hsa007500.47499187
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46520205
141Prolactin signaling pathway_Homo sapiens_hsa049170.46498898
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.46235570
143Dorso-ventral axis formation_Homo sapiens_hsa043200.45242010
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43920153
145Endocytosis_Homo sapiens_hsa041440.43823144
146Fatty acid elongation_Homo sapiens_hsa000620.37221569
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36478518
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.35823210
149Alcoholism_Homo sapiens_hsa050340.34720910
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34315516
151Insulin resistance_Homo sapiens_hsa049310.33071284
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32343961
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31619946

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