MDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.80318257
2nuclear pore organization (GO:0006999)5.62378158
3mitotic sister chromatid cohesion (GO:0007064)5.18354662
4DNA topological change (GO:0006265)4.86163143
5pre-miRNA processing (GO:0031054)4.64708158
6pore complex assembly (GO:0046931)4.52724755
7DNA unwinding involved in DNA replication (GO:0006268)4.43273565
8protein localization to kinetochore (GO:0034501)4.40514396
9heterochromatin organization (GO:0070828)4.19910198
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.14574206
11sister chromatid segregation (GO:0000819)4.12641595
12regulation of histone H3-K9 methylation (GO:0051570)4.10079201
13mitotic nuclear envelope disassembly (GO:0007077)4.08526554
14protein localization to chromosome, centromeric region (GO:0071459)4.07475755
15mitotic sister chromatid segregation (GO:0000070)4.06416567
16spliceosomal tri-snRNP complex assembly (GO:0000244)4.02767065
17nucleosome disassembly (GO:0006337)3.92587757
18protein-DNA complex disassembly (GO:0032986)3.92587757
19telomere maintenance via semi-conservative replication (GO:0032201)3.91836102
20mitotic chromosome condensation (GO:0007076)3.90966627
21translesion synthesis (GO:0019985)3.85603890
22DNA replication-dependent nucleosome organization (GO:0034723)3.82105513
23DNA replication-dependent nucleosome assembly (GO:0006335)3.82105513
24nuclear envelope disassembly (GO:0051081)3.81586355
25membrane disassembly (GO:0030397)3.81586355
26regulation of RNA export from nucleus (GO:0046831)3.80935233
27gene silencing by RNA (GO:0031047)3.78053223
28negative regulation of histone methylation (GO:0031061)3.74703986
29formation of translation preinitiation complex (GO:0001731)3.74166770
30DNA duplex unwinding (GO:0032508)3.72761044
31DNA geometric change (GO:0032392)3.71804686
32piRNA metabolic process (GO:0034587)3.62647525
33regulation of sister chromatid cohesion (GO:0007063)3.62011320
34regulation of histone H3-K27 methylation (GO:0061085)3.61688597
35DNA synthesis involved in DNA repair (GO:0000731)3.59822095
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52743123
37chromatin assembly (GO:0031497)3.51105912
38synaptonemal complex assembly (GO:0007130)3.50386130
39regulation of centriole replication (GO:0046599)3.47568006
40kinetochore organization (GO:0051383)3.46550201
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44548795
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.44548795
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44548795
44regulation of histone H3-K4 methylation (GO:0051569)3.43282360
45RNA stabilization (GO:0043489)3.42465898
46mRNA stabilization (GO:0048255)3.42465898
47meiotic chromosome segregation (GO:0045132)3.38126917
48positive regulation of chromosome segregation (GO:0051984)3.35140356
49regulation of DNA endoreduplication (GO:0032875)3.34913627
50DNA replication initiation (GO:0006270)3.32180345
51regulation of spindle organization (GO:0090224)3.31840106
52protein export from nucleus (GO:0006611)3.29807347
53dosage compensation (GO:0007549)3.29675163
54telomere maintenance via recombination (GO:0000722)3.28395609
55DNA conformation change (GO:0071103)3.28167540
56male meiosis (GO:0007140)3.26228291
57gene silencing (GO:0016458)3.25180944
58sister chromatid cohesion (GO:0007062)3.23960844
59synaptonemal complex organization (GO:0070193)3.23707743
60chromosome condensation (GO:0030261)3.22777102
61mitotic metaphase plate congression (GO:0007080)3.22105404
62paraxial mesoderm development (GO:0048339)3.19690482
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19606665
64DNA packaging (GO:0006323)3.16983866
65protein localization to chromosome (GO:0034502)3.16886478
66maturation of SSU-rRNA (GO:0030490)3.15864995
67folic acid-containing compound biosynthetic process (GO:0009396)3.13962825
68establishment of integrated proviral latency (GO:0075713)3.12510788
69positive regulation of DNA-dependent DNA replication (GO:2000105)3.12183939
70cilium or flagellum-dependent cell motility (GO:0001539)3.11810889
71chromosome organization involved in meiosis (GO:0070192)3.10974061
72metaphase plate congression (GO:0051310)3.10280982
73regulation of mitotic spindle organization (GO:0060236)3.09478897
74DNA strand elongation involved in DNA replication (GO:0006271)3.08709471
75regulation of chromosome segregation (GO:0051983)3.08676229
76negative regulation of DNA repair (GO:0045738)3.08420470
77regulation of histone methylation (GO:0031060)3.05117858
78chromatin assembly or disassembly (GO:0006333)3.04448088
79regulation of translational fidelity (GO:0006450)3.01566718
80ribosomal small subunit biogenesis (GO:0042274)3.01329787
81monoubiquitinated protein deubiquitination (GO:0035520)3.00576597
82RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00073559
83mRNA splicing, via spliceosome (GO:0000398)3.00073559
84protein complex localization (GO:0031503)2.98841188
85regulation of gene silencing by miRNA (GO:0060964)2.98714705
86regulation of gene silencing by RNA (GO:0060966)2.98714705
87regulation of posttranscriptional gene silencing (GO:0060147)2.98714705
88regulation of centrosome cycle (GO:0046605)2.98471342
89nuclear envelope organization (GO:0006998)2.98352082
90proline biosynthetic process (GO:0006561)2.97010883
91microtubule depolymerization (GO:0007019)2.96883038
92histone H3-K9 methylation (GO:0051567)2.95446202
93RNA splicing, via transesterification reactions (GO:0000375)2.94562951
94DNA strand elongation (GO:0022616)2.94496683
95V(D)J recombination (GO:0033151)2.93575967
96regulation of nucleobase-containing compound transport (GO:0032239)2.93032752
97IMP metabolic process (GO:0046040)2.92478757
98histone H2A monoubiquitination (GO:0035518)2.92114984
99postreplication repair (GO:0006301)2.90806464
100negative regulation of RNA splicing (GO:0033119)2.89695400
101mRNA transport (GO:0051028)2.88431321
102histone H4-K12 acetylation (GO:0043983)2.88250596
103NLS-bearing protein import into nucleus (GO:0006607)2.88094075
104attachment of spindle microtubules to kinetochore (GO:0008608)2.87497570
105negative regulation of mRNA metabolic process (GO:1903312)2.87051401
106meiotic nuclear division (GO:0007126)2.86107927
107glucocorticoid receptor signaling pathway (GO:0042921)2.86006944
108RNA transport (GO:0050658)2.84783827
109establishment of RNA localization (GO:0051236)2.84783827
110nucleic acid transport (GO:0050657)2.84783827
111positive regulation of gene expression, epigenetic (GO:0045815)2.84038264
112negative regulation of mRNA processing (GO:0050686)2.83679165
113ATP-dependent chromatin remodeling (GO:0043044)2.83142973
114DNA replication checkpoint (GO:0000076)2.81538185
115protein K6-linked ubiquitination (GO:0085020)2.81339242
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80409088
117mRNA export from nucleus (GO:0006406)2.79722948
118chromosome segregation (GO:0007059)2.79258901
119positive regulation of cell cycle checkpoint (GO:1901978)2.79111890
1203-UTR-mediated mRNA stabilization (GO:0070935)2.78855742
121mitotic recombination (GO:0006312)2.78547175
122regulation of meiosis I (GO:0060631)2.78436418
123IMP biosynthetic process (GO:0006188)2.77975371
124regulation of DNA damage checkpoint (GO:2000001)2.77962310
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77793191
126spindle organization (GO:0007051)2.76928146
127regulation of mRNA stability (GO:0043488)2.75300651
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75132942
129histone exchange (GO:0043486)2.74815590
130negative regulation of chromosome segregation (GO:0051985)2.74740138
131regulation of NFAT protein import into nucleus (GO:0051532)2.74673958
132double-strand break repair via nonhomologous end joining (GO:0006303)2.74671445
133non-recombinational repair (GO:0000726)2.74671445
134DNA replication-independent nucleosome organization (GO:0034724)2.74584807
135DNA replication-independent nucleosome assembly (GO:0006336)2.74584807
136kinetochore assembly (GO:0051382)2.74393047
137RNA export from nucleus (GO:0006405)2.72905448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.25834707
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.31498428
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18632937
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.55740912
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54198925
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07542076
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80756028
8MYC_22102868_ChIP-Seq_BL_Human2.71485811
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.71047363
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.58945805
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.43051995
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31982528
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.24023853
14AR_21909140_ChIP-Seq_LNCAP_Human2.18877155
15E2F7_22180533_ChIP-Seq_HELA_Human10.7952698
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90768689
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89996891
18THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89813427
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85782279
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84688724
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81648139
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81301746
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76059331
24CIITA_25753668_ChIP-Seq_RAJI_Human1.73386141
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65945641
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59351749
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54217061
28* XRN2_22483619_ChIP-Seq_HELA_Human1.51523222
29* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50384603
30* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46262710
31VDR_21846776_ChIP-Seq_THP-1_Human1.44578033
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43914918
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42597145
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42597145
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42597145
36KDM5A_27292631_Chip-Seq_BREAST_Human1.41667022
37* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39976142
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.39926270
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37256048
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.36712052
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35920780
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35417925
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32645657
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32150210
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31624816
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29916894
47* NANOG_21062744_ChIP-ChIP_HESCs_Human1.26101435
48* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24401723
49ZNF263_19887448_ChIP-Seq_K562_Human1.23079211
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22166268
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21693381
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21541586
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19571195
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18005123
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17412486
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17232375
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17134711
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.16933875
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14392055
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13657817
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13120381
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12971865
63* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12656230
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12225478
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09589515
66* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09224757
67* TTF2_22483619_ChIP-Seq_HELA_Human1.08944546
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08768873
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08589689
70* FOXP3_21729870_ChIP-Seq_TREG_Human1.07082163
71UTX_26944678_Chip-Seq_JUKART_Human1.06477726
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06259158
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05707120
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05612422
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03940345
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03866379
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03694388
78MYB_26560356_Chip-Seq_TH1_Human1.01545864
79KDM2B_26808549_Chip-Seq_DND41_Human1.00792887
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00363787
81* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99466193
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99116969
83RACK7_27058665_Chip-Seq_MCF-7_Human0.99046792
84TFEB_21752829_ChIP-Seq_HELA_Human0.96818524
85NCOR1_26117541_ChIP-Seq_K562_Human0.96427337
86LXR_22292898_ChIP-Seq_THP-1_Human0.96374206
87TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96116080
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.95274477
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95148563
90CLOCK_20551151_ChIP-Seq_293T_Human0.94561797
91* VDR_23849224_ChIP-Seq_CD4+_Human0.93843209
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93252030
93CHD1_26751641_Chip-Seq_LNCaP_Human0.92992880
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92839739
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91588998
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90823620
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90742161
98POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89428564
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89416701
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89124268
101YY1_21170310_ChIP-Seq_MESCs_Mouse0.89018991
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88781406
103* GABP_19822575_ChIP-Seq_HepG2_Human0.88780913
104MAF_26560356_Chip-Seq_TH1_Human0.88728293
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88655591
106MAF_26560356_Chip-Seq_TH2_Human0.88328934
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86942537
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.86842202
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86484041
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85706348
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84661835
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84656907
113MYB_26560356_Chip-Seq_TH2_Human0.84547087
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83808476
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83793454
116KDM2B_26808549_Chip-Seq_K562_Human0.83510354
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83364778
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83158327
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82807900
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82621690
121* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81318711
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81208628
123DCP1A_22483619_ChIP-Seq_HELA_Human0.81065151
124SCL_19346495_ChIP-Seq_HPC-7_Human0.79563021
125E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77444354
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76634317
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76370743
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75181164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability3.69094103
2MP0008057_abnormal_DNA_replication3.64671315
3MP0003111_abnormal_nucleus_morphology3.58580419
4MP0008877_abnormal_DNA_methylation3.34056521
5MP0003077_abnormal_cell_cycle3.10983635
6MP0003693_abnormal_embryo_hatching3.06887325
7MP0004957_abnormal_blastocyst_morpholog2.78642775
8MP0005076_abnormal_cell_differentiation2.55192789
9MP0010352_gastrointestinal_tract_polyps2.40166730
10MP0010307_abnormal_tumor_latency2.27699488
11MP0008007_abnormal_cellular_replicative2.18454179
12MP0001730_embryonic_growth_arrest2.16057573
13MP0003123_paternal_imprinting2.04345221
14MP0002396_abnormal_hematopoietic_system2.03861733
15* MP0008058_abnormal_DNA_repair2.01596795
16MP0003121_genomic_imprinting2.01385371
17* MP0000350_abnormal_cell_proliferation1.99485300
18MP0009278_abnormal_bone_marrow1.92288960
19MP0001672_abnormal_embryogenesis/_devel1.92051810
20MP0005380_embryogenesis_phenotype1.92051810
21MP0002084_abnormal_developmental_patter1.91382274
22MP0002009_preneoplasia1.90758579
23MP0004197_abnormal_fetal_growth/weight/1.89755718
24MP0004808_abnormal_hematopoietic_stem1.88930275
25MP0003984_embryonic_growth_retardation1.79270327
26MP0000678_abnormal_parathyroid_gland1.78946489
27MP0005410_abnormal_fertilization1.77541378
28MP0002088_abnormal_embryonic_growth/wei1.76811503
29MP0005451_abnormal_body_composition1.76171767
30MP0002085_abnormal_embryonic_tissue1.74275893
31MP0002249_abnormal_larynx_morphology1.70876960
32MP0001697_abnormal_embryo_size1.69118154
33* MP0002210_abnormal_sex_determination1.67698491
34* MP0001929_abnormal_gametogenesis1.66865087
35MP0002653_abnormal_ependyma_morphology1.64692981
36MP0002086_abnormal_extraembryonic_tissu1.63922218
37MP0003705_abnormal_hypodermis_morpholog1.62417424
38MP0004185_abnormal_adipocyte_glucose1.61443629
39MP0003890_abnormal_embryonic-extraembry1.57311317
40MP0003567_abnormal_fetal_cardiomyocyte1.53872268
41MP0008932_abnormal_embryonic_tissue1.53003536
42MP0000569_abnormal_digit_pigmentation1.50328181
43MP0000566_synostosis1.48444502
44MP0010030_abnormal_orbit_morphology1.48325804
45MP0002080_prenatal_lethality1.47134716
46MP0001293_anophthalmia1.47101633
47* MP0001145_abnormal_male_reproductive1.45484724
48MP0000537_abnormal_urethra_morphology1.43887724
49MP0009697_abnormal_copulation1.36596002
50* MP0003698_abnormal_male_reproductive1.34433269
51MP0001346_abnormal_lacrimal_gland1.31530238
52MP0003786_premature_aging1.30899354
53MP0003787_abnormal_imprinting1.29131660
54MP0001849_ear_inflammation1.24501574
55MP0003315_abnormal_perineum_morphology1.23697133
56MP0003115_abnormal_respiratory_system1.22585653
57* MP0000653_abnormal_sex_gland1.20675067
58MP0003283_abnormal_digestive_organ1.20578343
59MP0005397_hematopoietic_system_phenotyp1.19515291
60MP0001545_abnormal_hematopoietic_system1.19515291
61MP0000428_abnormal_craniofacial_morphol1.18886491
62MP0009053_abnormal_anal_canal1.18770122
63MP0000733_abnormal_muscle_development1.18163264
64MP0009703_decreased_birth_body1.16485411
65* MP0000313_abnormal_cell_death1.15821626
66MP0004264_abnormal_extraembryonic_tissu1.15176640
67MP0005623_abnormal_meninges_morphology1.13379093
68MP0003119_abnormal_digestive_system1.11866123
69MP0003566_abnormal_cell_adhesion1.10746438
70MP0000490_abnormal_crypts_of1.09613896
71MP0002019_abnormal_tumor_incidence1.08381819
72MP0001348_abnormal_lacrimal_gland1.06261207
73MP0009672_abnormal_birth_weight1.05585156
74MP0003935_abnormal_craniofacial_develop1.05288745
75MP0001661_extended_life_span1.02909521
76MP0003937_abnormal_limbs/digits/tail_de1.02692163
77MP0002092_abnormal_eye_morphology1.02583882
78MP0002697_abnormal_eye_size1.01567375
79MP0001915_intracranial_hemorrhage1.00675367
80MP0002925_abnormal_cardiovascular_devel1.00421159
81MP0000432_abnormal_head_morphology0.99115522
82* MP0000703_abnormal_thymus_morphology0.99054612
83MP0006292_abnormal_olfactory_placode0.97499989
84MP0002160_abnormal_reproductive_system0.88801761
85MP0004233_abnormal_muscle_weight0.88648431
86MP0002877_abnormal_melanocyte_morpholog0.87305949
87MP0008995_early_reproductive_senescence0.87238219
88MP0003943_abnormal_hepatobiliary_system0.84544355
89* MP0002161_abnormal_fertility/fecundity0.83287784
90MP0005409_darkened_coat_color0.82601683
91MP0006054_spinal_hemorrhage0.81413587
92MP0002111_abnormal_tail_morphology0.81248601
93MP0005666_abnormal_adipose_tissue0.80633368
94MP0005023_abnormal_wound_healing0.80192512
95MP0002114_abnormal_axial_skeleton0.79960471
96MP0001286_abnormal_eye_development0.79359809
97MP0002089_abnormal_postnatal_growth/wei0.77421003
98MP0003122_maternal_imprinting0.77080814
99* MP0002398_abnormal_bone_marrow0.76495622
100MP0010234_abnormal_vibrissa_follicle0.75651017
101MP0003763_abnormal_thymus_physiology0.75500522
102MP0000003_abnormal_adipose_tissue0.75413786
103MP0000266_abnormal_heart_morphology0.74872457
104MP0003861_abnormal_nervous_system0.74656092
105MP0002282_abnormal_trachea_morphology0.74216616
106MP0005501_abnormal_skin_physiology0.72281812
107MP0003755_abnormal_palate_morphology0.71368149
108MP0005621_abnormal_cell_physiology0.71331984
109MP0002081_perinatal_lethality0.71033937
110MP0003699_abnormal_female_reproductive0.70168141
111MP0002970_abnormal_white_adipose0.70031048
112MP0002116_abnormal_craniofacial_bone0.69390678
113MP0001119_abnormal_female_reproductive0.69040615
114MP0003941_abnormal_skin_development0.68726008
115MP0005384_cellular_phenotype0.68402214
116MP0010630_abnormal_cardiac_muscle0.68126294
117MP0003385_abnormal_body_wall0.68110023
118MP0003718_maternal_effect0.67654646
119MP0002932_abnormal_joint_morphology0.66494028
120MP0003942_abnormal_urinary_system0.65334695
121MP0001784_abnormal_fluid_regulation0.64513016
122MP0008961_abnormal_basal_metabolism0.64466223
123MP0004133_heterotaxia0.64179305
124* MP0002722_abnormal_immune_system0.64070946
125MP0003300_gastrointestinal_ulcer0.63996475
126MP0003221_abnormal_cardiomyocyte_apopto0.61882976
127MP0002269_muscular_atrophy0.60647772
128MP0005375_adipose_tissue_phenotype0.59837355

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.88268851
2Chromsome breakage (HP:0040012)3.68985981
3Ependymoma (HP:0002888)3.59134483
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49180473
5Selective tooth agenesis (HP:0001592)3.42416057
6Increased nuchal translucency (HP:0010880)3.35508151
7Ectopic kidney (HP:0000086)3.22004468
8Short 4th metacarpal (HP:0010044)3.19176944
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19176944
10Cholecystitis (HP:0001082)2.92764087
11Abnormal gallbladder physiology (HP:0012438)2.92764087
12Medulloblastoma (HP:0002885)2.88247709
13Astrocytoma (HP:0009592)2.85709537
14Abnormality of the astrocytes (HP:0100707)2.85709537
15Abnormality of cochlea (HP:0000375)2.80856925
16Impulsivity (HP:0100710)2.79409025
17Abnormality of chromosome stability (HP:0003220)2.78227289
18Abnormality of the fingertips (HP:0001211)2.69909464
19Overlapping toe (HP:0001845)2.64981074
20Long eyelashes (HP:0000527)2.63487637
21Proximal placement of thumb (HP:0009623)2.61632070
22Heterotopia (HP:0002282)2.60096668
23Deviation of the thumb (HP:0009603)2.60026620
24Hyperacusis (HP:0010780)2.59561340
25Reticulocytopenia (HP:0001896)2.58676482
26Ankyloglossia (HP:0010296)2.54131026
27Prominent nose (HP:0000448)2.52197752
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.50145390
29Neoplasm of the oral cavity (HP:0100649)2.46493144
30Meckel diverticulum (HP:0002245)2.46261304
31Urethral obstruction (HP:0000796)2.46083559
32Glioma (HP:0009733)2.45475228
33Renal duplication (HP:0000075)2.45029001
34High anterior hairline (HP:0009890)2.44250887
35Dysmetric saccades (HP:0000641)2.42521252
36Cortical dysplasia (HP:0002539)2.42416362
37Deep palmar crease (HP:0006191)2.41418024
38Insomnia (HP:0100785)2.40765982
39Truncus arteriosus (HP:0001660)2.39435892
40Supernumerary ribs (HP:0005815)2.36571468
41Abnormality of the ileum (HP:0001549)2.36166051
42High pitched voice (HP:0001620)2.35454613
43Septate vagina (HP:0001153)2.34955498
44Abnormality of the carotid arteries (HP:0005344)2.33213592
45Abnormality of the calcaneus (HP:0008364)2.32733310
46Disproportionate tall stature (HP:0001519)2.31943390
47Abnormal number of incisors (HP:0011064)2.31858598
48Abnormality of reticulocytes (HP:0004312)2.30604318
49Renovascular hypertension (HP:0100817)2.29456564
50Abnormality of the 4th metacarpal (HP:0010012)2.29196250
51Abnormality of the preputium (HP:0100587)2.28371765
52Progressive muscle weakness (HP:0003323)2.27125675
53Colon cancer (HP:0003003)2.25902608
54Missing ribs (HP:0000921)2.24636676
55Duplication of thumb phalanx (HP:0009942)2.19255176
56Abnormality of chromosome segregation (HP:0002916)2.19227708
57Reticulocytosis (HP:0001923)2.17306978
58Morphological abnormality of the inner ear (HP:0011390)2.16165898
59Homocystinuria (HP:0002156)2.15420868
60Abnormality of homocysteine metabolism (HP:0010919)2.15420868
6111 pairs of ribs (HP:0000878)2.14839434
62Truncal obesity (HP:0001956)2.13647517
63Myelodysplasia (HP:0002863)2.12866601
64Supernumerary bones of the axial skeleton (HP:0009144)2.12111843
65Bowel incontinence (HP:0002607)2.11999232
66Skull defect (HP:0001362)2.09984243
67Duodenal stenosis (HP:0100867)2.09801175
68Small intestinal stenosis (HP:0012848)2.09801175
69Long palpebral fissure (HP:0000637)2.08102102
70Trigonocephaly (HP:0000243)2.08024563
71Neoplasm of striated muscle (HP:0009728)2.05520285
72Basal cell carcinoma (HP:0002671)2.05230532
73Ulnar bowing (HP:0003031)2.02549660
74Abnormality of the phalanges of the hallux (HP:0010057)2.02506324
75Rhabdomyosarcoma (HP:0002859)2.02196365
76Elfin facies (HP:0004428)2.00635755
77Patellar dislocation (HP:0002999)2.00362002
78Abnormal large intestine physiology (HP:0012700)2.00137902
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.98457176
80Absent frontal sinuses (HP:0002688)1.98230642
81Metaphyseal cupping (HP:0003021)1.96671036
82Intestinal fistula (HP:0100819)1.96487053
83Cafe-au-lait spot (HP:0000957)1.95141014
84Gastrointestinal carcinoma (HP:0002672)1.94821092
85Malignant gastrointestinal tract tumors (HP:0006749)1.94821092
86Sloping forehead (HP:0000340)1.93824356
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93770723
88Thin ribs (HP:0000883)1.92847437
89Abnormality of oral frenula (HP:0000190)1.92578480
90Broad palm (HP:0001169)1.92428747
91Progressive external ophthalmoplegia (HP:0000590)1.92384902
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.90066042
93Aplasia involving forearm bones (HP:0009822)1.88492787
94Absent forearm bone (HP:0003953)1.88492787
95Obsessive-compulsive behavior (HP:0000722)1.87399892
96Atresia of the external auditory canal (HP:0000413)1.87391854
97Abnormality of the labia minora (HP:0012880)1.86908425
98Supernumerary spleens (HP:0009799)1.85517305
99Attention deficit hyperactivity disorder (HP:0007018)1.84286701
100Patellar aplasia (HP:0006443)1.84207113
101Birth length less than 3rd percentile (HP:0003561)1.84017215
102Nephroblastoma (Wilms tumor) (HP:0002667)1.84008418
103Self-mutilation (HP:0000742)1.83942134
104Abnormality of abdominal situs (HP:0011620)1.83197531
105Abdominal situs inversus (HP:0003363)1.83197531
106Broad thumb (HP:0011304)1.82431824
107Asymmetry of the thorax (HP:0001555)1.81150443
108Abnormality of the duodenum (HP:0002246)1.80226908
109Facial hemangioma (HP:0000329)1.79918493
110Sandal gap (HP:0001852)1.79435990
111Embryonal neoplasm (HP:0002898)1.79390295
112Dislocated radial head (HP:0003083)1.78909771
113Anal stenosis (HP:0002025)1.78017225
114Squamous cell carcinoma (HP:0002860)1.77121762
115Low anterior hairline (HP:0000294)1.76969416
116Deep philtrum (HP:0002002)1.76947855
117Absent thumb (HP:0009777)1.76539880
118Agnosia (HP:0010524)1.76048981
119Cutis marmorata (HP:0000965)1.75859566
120Abnormality of the anterior horn cell (HP:0006802)1.75409222
121Degeneration of anterior horn cells (HP:0002398)1.75409222
122Pseudobulbar signs (HP:0002200)1.75403249
123Overriding aorta (HP:0002623)1.75145435
124Short middle phalanx of the 5th finger (HP:0004220)1.74848074
125Preauricular skin tag (HP:0000384)1.74095591
126Choanal atresia (HP:0000453)1.74075834
127Pointed chin (HP:0000307)1.73920765
128Biliary tract neoplasm (HP:0100574)1.73778896
129Broad distal phalanx of finger (HP:0009836)1.72610786
130Duplicated collecting system (HP:0000081)1.72231974
131Acute myeloid leukemia (HP:0004808)1.71852477
132Abnormality of the diencephalon (HP:0010662)1.71196196
133Absent radius (HP:0003974)1.70613884
134Hyperthyroidism (HP:0000836)1.69450129
135Skin tags (HP:0010609)1.68945973
136Horseshoe kidney (HP:0000085)1.68881762
137Abnormality of the radial head (HP:0003995)1.68865111
138Macroorchidism (HP:0000053)1.68654659
139Aplasia/Hypoplasia of the patella (HP:0006498)1.68115092
140Rib fusion (HP:0000902)1.68019676
141Abnormality of the lower motor neuron (HP:0002366)1.67922509
142Embryonal renal neoplasm (HP:0011794)1.67569153
143Bowel diverticulosis (HP:0005222)1.67414316
144Short thumb (HP:0009778)1.67225538
145Oligodactyly (HP:0012165)1.66492919
146Broad phalanges of the hand (HP:0009768)1.66328023
147Orthostatic hypotension (HP:0001278)1.65951888
148Sparse lateral eyebrow (HP:0005338)1.65634104
149Limited elbow extension (HP:0001377)1.65516495
150Shallow orbits (HP:0000586)1.64886032
151Tracheoesophageal fistula (HP:0002575)1.64736798
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64503307
153Breast hypoplasia (HP:0003187)1.64446044
154Flat cornea (HP:0007720)1.63389919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.35189089
2CDC74.40105369
3NEK23.36651320
4EEF2K3.34374753
5SMG13.06754325
6BRD42.71843631
7MAP3K102.45567774
8TTK2.44639442
9WEE12.39459173
10ICK2.09994178
11PDK32.00569210
12PDK42.00569210
13PASK1.85914542
14* ATR1.84647756
15LATS11.81437077
16CDK41.74646326
17CDK71.70450756
18RPS6KB21.66959932
19STK101.66316714
20PRPF4B1.61706701
21STK31.60941673
22MTOR1.53687547
23CDK61.52840477
24PKN21.50441703
25MAP3K131.50307172
26* CHEK11.49556890
27PLK11.47012680
28CHEK21.43248754
29KSR21.37593927
30SRPK11.36103152
31NEK11.34231238
32TSSK61.33707068
33CAMK1D1.33650997
34MKNK11.32536272
35CAMK1G1.31680684
36PNCK1.31410991
37BUB11.28893954
38ATM1.27552648
39AURKB1.24202501
40TRIB31.23542356
41FGFR41.21514418
42IRAK31.19359882
43STK41.19232726
44RPS6KA41.15270665
45PAK41.12562463
46ALK1.07845922
47BRAF1.05067871
48MKNK21.02581026
49* CDK21.02034524
50MAP3K81.01270676
51PLK30.99159271
52PTK60.95239894
53BRSK20.93858734
54NME20.92257257
55PDK20.92051867
56TGFBR10.91996091
57PIM10.89813676
58CDK90.88507502
59PRKD30.87149960
60MAP3K90.84384040
61CDK10.81174004
62PLK40.77853215
63MELK0.77183457
64PBK0.76352997
65RIPK10.76172249
66MAP4K10.75975360
67DYRK30.75791975
68PAK20.74030531
69TESK10.73970002
70CDK80.71222478
71ACVR1B0.69898249
72VRK20.69515847
73TTN0.66865766
74RAF10.65268930
75FLT30.64733426
76TAF10.61182090
77FGFR10.60575721
78CHUK0.60044033
79SCYL20.59992714
80CSNK1D0.59612332
81TAOK10.58984856
82EPHA20.58018121
83MAPK140.57714502
84PDGFRA0.57320032
85BRSK10.57107076
86PRKDC0.55544083
87MAPK110.54630191
88CDK30.53996020
89EIF2AK10.53741256
90DYRK1B0.52181541
91MAPK100.51544105
92ERN10.51270224
93MAP2K30.50973834
94MAPK10.49734675
95KSR10.49518417
96CSNK1E0.48303798
97LATS20.47488444
98SIK10.47387911
99NME10.46964212
100CCNB10.46178015
101SIK30.46009972
102AKT10.46003182
103BMX0.45950584
104GSK3B0.45766615
105AURKA0.44782208
106CLK10.42864149
107CDK11A0.42782860
108TYRO30.41943709
109PDGFRB0.40160817
110STK38L0.39005283
111SIK20.38441390
112CSNK2A20.38430672
113CDK150.38293908
114AKT20.38111017
115LRRK20.37857736
116MAP2K20.37800975
117MARK30.35389793
118EIF2AK20.34919726
119FGFR30.33671998
120CDK180.33531769
121CDC42BPA0.33049049
122ZAK0.32355209
123BTK0.32065656
124DMPK0.30504553
125WNK10.30476929
126CSF1R0.30339139
127PAK10.29734822

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.78183381
2Mismatch repair_Homo sapiens_hsa034303.45289058
3Cell cycle_Homo sapiens_hsa041103.02601243
4RNA transport_Homo sapiens_hsa030132.90865300
5Fanconi anemia pathway_Homo sapiens_hsa034602.72312476
6Spliceosome_Homo sapiens_hsa030402.70625414
7mRNA surveillance pathway_Homo sapiens_hsa030152.56434033
8Homologous recombination_Homo sapiens_hsa034402.50622310
9Base excision repair_Homo sapiens_hsa034102.48287983
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39972455
11One carbon pool by folate_Homo sapiens_hsa006702.13739857
12Nucleotide excision repair_Homo sapiens_hsa034201.95870073
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82437631
14Non-homologous end-joining_Homo sapiens_hsa034501.82154594
15p53 signaling pathway_Homo sapiens_hsa041151.74379281
16Lysine degradation_Homo sapiens_hsa003101.69801234
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68059065
18RNA degradation_Homo sapiens_hsa030181.65624702
19Basal transcription factors_Homo sapiens_hsa030221.61465565
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52808527
21Basal cell carcinoma_Homo sapiens_hsa052171.50681321
22MicroRNAs in cancer_Homo sapiens_hsa052061.49163406
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39092676
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38817776
25Viral carcinogenesis_Homo sapiens_hsa052031.36191275
26Notch signaling pathway_Homo sapiens_hsa043301.35478297
27Herpes simplex infection_Homo sapiens_hsa051681.31859832
28HTLV-I infection_Homo sapiens_hsa051661.31837826
29Oocyte meiosis_Homo sapiens_hsa041141.30805178
30Antigen processing and presentation_Homo sapiens_hsa046121.29800997
31Small cell lung cancer_Homo sapiens_hsa052221.28578412
32Chronic myeloid leukemia_Homo sapiens_hsa052201.26456020
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25132180
34Adherens junction_Homo sapiens_hsa045201.24875129
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20748265
36Ribosome_Homo sapiens_hsa030101.19593357
37Hippo signaling pathway_Homo sapiens_hsa043901.18572774
38Dorso-ventral axis formation_Homo sapiens_hsa043201.14455502
39Epstein-Barr virus infection_Homo sapiens_hsa051691.05283756
40Colorectal cancer_Homo sapiens_hsa052101.05252010
41Selenocompound metabolism_Homo sapiens_hsa004501.03745571
42Carbon metabolism_Homo sapiens_hsa012001.03737611
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01867316
44TGF-beta signaling pathway_Homo sapiens_hsa043501.00580158
45Renal cell carcinoma_Homo sapiens_hsa052111.00415681
46mTOR signaling pathway_Homo sapiens_hsa041500.99080295
47Hedgehog signaling pathway_Homo sapiens_hsa043400.97633478
48Pyrimidine metabolism_Homo sapiens_hsa002400.94510859
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93011631
50Prostate cancer_Homo sapiens_hsa052150.89664834
51ErbB signaling pathway_Homo sapiens_hsa040120.89169403
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87411314
53Systemic lupus erythematosus_Homo sapiens_hsa053220.86665346
54Insulin signaling pathway_Homo sapiens_hsa049100.85433398
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85001584
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.84913780
57Viral myocarditis_Homo sapiens_hsa054160.84831056
58Thyroid cancer_Homo sapiens_hsa052160.80863989
59Acute myeloid leukemia_Homo sapiens_hsa052210.79370164
60Endometrial cancer_Homo sapiens_hsa052130.78270961
61Proteoglycans in cancer_Homo sapiens_hsa052050.78212168
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77897825
63Wnt signaling pathway_Homo sapiens_hsa043100.77069267
64Pyruvate metabolism_Homo sapiens_hsa006200.76948501
65Pathways in cancer_Homo sapiens_hsa052000.76883266
66Fructose and mannose metabolism_Homo sapiens_hsa000510.76872002
67Hepatitis B_Homo sapiens_hsa051610.76389024
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75046870
69Pancreatic cancer_Homo sapiens_hsa052120.74105789
70Prion diseases_Homo sapiens_hsa050200.73092866
71Non-small cell lung cancer_Homo sapiens_hsa052230.72248708
72B cell receptor signaling pathway_Homo sapiens_hsa046620.72104129
73RNA polymerase_Homo sapiens_hsa030200.71530981
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71020179
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.70957749
76Primary immunodeficiency_Homo sapiens_hsa053400.68808939
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67181258
78Measles_Homo sapiens_hsa051620.65870272
79Influenza A_Homo sapiens_hsa051640.63801107
80FoxO signaling pathway_Homo sapiens_hsa040680.62047525
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61925942
82Choline metabolism in cancer_Homo sapiens_hsa052310.61040593
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.59984961
84Glucagon signaling pathway_Homo sapiens_hsa049220.58000465
85HIF-1 signaling pathway_Homo sapiens_hsa040660.56154896
86Legionellosis_Homo sapiens_hsa051340.55153906
87Apoptosis_Homo sapiens_hsa042100.54843716
88Toxoplasmosis_Homo sapiens_hsa051450.53030671
89Focal adhesion_Homo sapiens_hsa045100.52247146
90Bladder cancer_Homo sapiens_hsa052190.52227349
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51795158
92T cell receptor signaling pathway_Homo sapiens_hsa046600.51317353
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.50793998
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50361285
95Tight junction_Homo sapiens_hsa045300.50055263
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.49702617
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48999517
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48732856
99AMPK signaling pathway_Homo sapiens_hsa041520.48309023
100Purine metabolism_Homo sapiens_hsa002300.46012673
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45202781
102Estrogen signaling pathway_Homo sapiens_hsa049150.44762094
103ECM-receptor interaction_Homo sapiens_hsa045120.43145026
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41896861
105Insulin resistance_Homo sapiens_hsa049310.41384017
106Biosynthesis of amino acids_Homo sapiens_hsa012300.41066383
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40790911
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40560024
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40140376
110N-Glycan biosynthesis_Homo sapiens_hsa005100.40012454
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39832595
112Melanoma_Homo sapiens_hsa052180.39180924
113Vitamin B6 metabolism_Homo sapiens_hsa007500.37298189
114Type II diabetes mellitus_Homo sapiens_hsa049300.36823334
115VEGF signaling pathway_Homo sapiens_hsa043700.36037550
116Shigellosis_Homo sapiens_hsa051310.35905608
117Inositol phosphate metabolism_Homo sapiens_hsa005620.35740823
118Prolactin signaling pathway_Homo sapiens_hsa049170.35604969
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35533877
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.35495192
121Pentose phosphate pathway_Homo sapiens_hsa000300.34141787
122Glioma_Homo sapiens_hsa052140.34101810
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33880589
124Long-term potentiation_Homo sapiens_hsa047200.33804581
125Melanogenesis_Homo sapiens_hsa049160.33539132

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