MCU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)4.93663121
2positive regulation of megakaryocyte differentiation (GO:0045654)4.71184506
3skeletal muscle contraction (GO:0003009)4.58112504
4myoblast migration (GO:0051451)4.56705242
5nuclear pore complex assembly (GO:0051292)4.47975327
6Golgi transport vesicle coating (GO:0048200)4.30049312
7COPI coating of Golgi vesicle (GO:0048205)4.30049312
8actin filament-based movement (GO:0030048)4.23063830
9protein retention in ER lumen (GO:0006621)4.21690384
10purine nucleotide salvage (GO:0032261)4.16036123
11positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.15190402
12sarcoplasmic reticulum calcium ion transport (GO:0070296)4.09763591
13negative regulation of keratinocyte proliferation (GO:0010839)3.93420047
14nuclear pore organization (GO:0006999)3.82027252
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.77472207
16cellular glucuronidation (GO:0052695)3.77094747
17intestinal cholesterol absorption (GO:0030299)3.76624606
18positive regulation of keratinocyte differentiation (GO:0045618)3.69785405
19positive regulation of mitochondrial fission (GO:0090141)3.64932128
20NADH metabolic process (GO:0006734)3.64727357
21regulation of RIG-I signaling pathway (GO:0039535)3.64299219
22inositol phosphate catabolic process (GO:0071545)3.61773617
23negative regulation of homotypic cell-cell adhesion (GO:0034111)3.58276341
24IMP metabolic process (GO:0046040)3.57006264
25response to fungus (GO:0009620)3.55463073
26epithelial cell-cell adhesion (GO:0090136)3.55355556
27angiotensin maturation (GO:0002003)3.54906579
28actin filament depolymerization (GO:0030042)3.54863749
29negative regulation of hormone metabolic process (GO:0032351)3.54146445
30negative regulation of hormone biosynthetic process (GO:0032353)3.54146445
31regulation of female gonad development (GO:2000194)3.53667484
32heart contraction (GO:0060047)3.53586531
33heart process (GO:0003015)3.53586531
34negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.52222536
35nucleotide-sugar metabolic process (GO:0009225)3.51808190
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.49458553
373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.49458553
38negative regulation of steroid biosynthetic process (GO:0010894)3.48154225
39defense response to fungus (GO:0050832)3.45127274
40notochord development (GO:0030903)3.44071348
41pentose-phosphate shunt (GO:0006098)3.40240490
42killing of cells of other organism (GO:0031640)3.39537612
43disruption of cells of other organism (GO:0044364)3.39537612
44sarcomere organization (GO:0045214)3.37396523
45adenosine metabolic process (GO:0046085)3.32862125
46generation of neurons (GO:0048699)3.32330962
47nucleotide-sugar biosynthetic process (GO:0009226)3.31245496
48negative regulation of steroid metabolic process (GO:0045939)3.29755795
49plasma membrane repair (GO:0001778)3.29417283
50tricarboxylic acid cycle (GO:0006099)3.27716428
51NADPH regeneration (GO:0006740)3.27357709
52maintenance of gastrointestinal epithelium (GO:0030277)3.26155236
53negative regulation of dendrite morphogenesis (GO:0050774)3.25782988
54regulation of relaxation of muscle (GO:1901077)3.25780516
55desmosome organization (GO:0002934)3.24587272
56phospholipid scrambling (GO:0017121)3.24098224
57COPII vesicle coating (GO:0048208)3.23717004
58* positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.20711373
59glucose 6-phosphate metabolic process (GO:0051156)3.16832919
60actin-mediated cell contraction (GO:0070252)3.15390353
61uronic acid metabolic process (GO:0006063)3.15388122
62glucuronate metabolic process (GO:0019585)3.15388122
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15050848
64regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.14829162
65protein K11-linked deubiquitination (GO:0035871)3.13757731
66establishment of integrated proviral latency (GO:0075713)3.13616211
67cellular protein complex localization (GO:0034629)3.13469391
68killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.12554467
69disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.12554467
70keratan sulfate biosynthetic process (GO:0018146)3.11896394
71positive regulation of actin filament depolymerization (GO:0030836)3.11112114
72focal adhesion assembly (GO:0048041)3.09291749
73cell-substrate adherens junction assembly (GO:0007045)3.09291749
74pore complex assembly (GO:0046931)3.09057307
75protein complex localization (GO:0031503)3.07852023
76regulation of skeletal muscle contraction (GO:0014819)3.02897645
77regulation of germinal center formation (GO:0002634)3.02396973
78hippo signaling (GO:0035329)3.00663421
79hepatocyte apoptotic process (GO:0097284)2.99848560
80phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99792010
81peripheral nervous system neuron development (GO:0048935)2.99032904
82response to muscle activity (GO:0014850)2.98567505
83glucan catabolic process (GO:0009251)2.98083099
84UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97957681
85actin nucleation (GO:0045010)2.97771598
86negative regulation of protein localization to plasma membrane (GO:1903077)2.96941621
87regulation of glucocorticoid metabolic process (GO:0031943)2.96894721
88signal peptide processing (GO:0006465)2.96249526
89glycogen catabolic process (GO:0005980)2.96006934
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95050527
91mitotic chromosome condensation (GO:0007076)2.94980256
92IMP biosynthetic process (GO:0006188)2.93159031
93detection of bacterium (GO:0016045)2.93062134
94cellular polysaccharide catabolic process (GO:0044247)2.92001166
95positive regulation of epidermal cell differentiation (GO:0045606)2.91396321
96proline biosynthetic process (GO:0006561)2.89173241
97phosphorylated carbohydrate dephosphorylation (GO:0046838)2.87269827
98inositol phosphate dephosphorylation (GO:0046855)2.87269827
99adherens junction assembly (GO:0034333)2.87254107
100cell-substrate junction assembly (GO:0007044)2.86960298
101removal of superoxide radicals (GO:0019430)2.84454714
102cellular response to superoxide (GO:0071451)2.84454714
103cellular response to oxygen radical (GO:0071450)2.84454714
104actomyosin structure organization (GO:0031032)2.83321343
105ribosome assembly (GO:0042255)2.81810092
106skin morphogenesis (GO:0043589)2.81581806
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.81405476
108glycolytic process (GO:0006096)2.81386031
109polyketide metabolic process (GO:0030638)2.80115431
110doxorubicin metabolic process (GO:0044598)2.80115431
111daunorubicin metabolic process (GO:0044597)2.80115431
112hypotonic response (GO:0006971)2.78876772
113cell adhesion mediated by integrin (GO:0033627)2.78598468
114barbed-end actin filament capping (GO:0051016)2.78410661
115DNA unwinding involved in DNA replication (GO:0006268)2.77508302
116membrane budding (GO:0006900)2.76234227
117negative regulation of alcohol biosynthetic process (GO:1902931)2.75466261
118negative regulation of mast cell activation (GO:0033004)2.74889794
119regulation of cell maturation (GO:1903429)2.73423484
120paraxial mesoderm development (GO:0048339)2.73059007
121striated muscle contraction (GO:0006941)2.72871276
122detection of other organism (GO:0098543)2.72493874
123sulfate transmembrane transport (GO:1902358)2.72409932
124vesicle coating (GO:0006901)2.72111146
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70774645
126protein deneddylation (GO:0000338)2.70354977
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.70135175
128glucose catabolic process (GO:0006007)2.69178841
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67190041
130citrulline biosynthetic process (GO:0019240)2.66872588
131nucleoside diphosphate biosynthetic process (GO:0009133)2.66454223
132peptide catabolic process (GO:0043171)2.66079072
133actin-myosin filament sliding (GO:0033275)2.65314613
134muscle filament sliding (GO:0030049)2.65314613
135polysaccharide catabolic process (GO:0000272)2.63443165
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63223573
137regulation of pseudopodium assembly (GO:0031272)2.62388502
138regulation of G0 to G1 transition (GO:0070316)2.62150479
139negative regulation of mitochondrion organization (GO:0010823)2.61008333
140diterpenoid biosynthetic process (GO:0016102)2.60739615
141regulation of metalloenzyme activity (GO:0048552)2.60418568
142negative regulation of potassium ion transmembrane transport (GO:1901380)2.60051320
143regulation of transforming growth factor beta2 production (GO:0032909)2.59742245
144AMP metabolic process (GO:0046033)2.59700267
145flavonoid metabolic process (GO:0009812)2.59571166
146protein heterotetramerization (GO:0051290)2.58582454
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.58291357
148deoxyribose phosphate biosynthetic process (GO:0046385)2.58291357
149embryonic process involved in female pregnancy (GO:0060136)2.58073816
150protein hydroxylation (GO:0018126)2.57183280
151positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56760990
152purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.56494417
153digestive system process (GO:0022600)2.56456857
154sequestering of actin monomers (GO:0042989)2.56275904
155localization within membrane (GO:0051668)2.55824445
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55677398
157negative regulation of necroptotic process (GO:0060546)2.55320674
158peptidyl-proline hydroxylation (GO:0019511)2.55254241
159regulation of keratinocyte differentiation (GO:0045616)2.54809867
160relaxation of smooth muscle (GO:0044557)2.54307558
161glomerular visceral epithelial cell development (GO:0072015)2.52725807
162negative regulation of leukocyte migration (GO:0002686)2.51311461
163nucleobase-containing small molecule interconversion (GO:0015949)2.50772515
164muscle cell fate commitment (GO:0042693)2.50703834
165thrombin receptor signaling pathway (GO:0070493)2.50649196
166negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.50430021
167skeletal muscle tissue regeneration (GO:0043403)2.50258407
168gluconeogenesis (GO:0006094)2.49556376
169* mitochondrial calcium ion transport (GO:0006851)2.49120496
170regulation of receptor recycling (GO:0001919)2.47421472
171skeletal muscle fiber development (GO:0048741)2.46336296
172vitamin A metabolic process (GO:0006776)2.46109310
173regulation of early endosome to late endosome transport (GO:2000641)2.45957144
174response to hepatocyte growth factor (GO:0035728)2.45867646
175cellular response to hepatocyte growth factor stimulus (GO:0035729)2.45867646
176negative regulation of protein localization to cell surface (GO:2000009)2.45323655
177monosaccharide biosynthetic process (GO:0046364)2.45311097
178oocyte maturation (GO:0001556)2.44826458
179aminoglycoside antibiotic metabolic process (GO:0030647)2.43307663
180muscle cell migration (GO:0014812)2.42329050
181protein localization to endosome (GO:0036010)2.39648356
182hemidesmosome assembly (GO:0031581)2.38877659
183glomerular epithelial cell development (GO:0072310)2.38866041
184muscle contraction (GO:0006936)2.36199061
185myotube cell development (GO:0014904)2.35341737
186regulation of translational termination (GO:0006449)2.34764115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.94103811
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.57820053
3E2F7_22180533_ChIP-Seq_HELA_Human3.78469209
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.69333669
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.13169546
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90421952
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77361826
8ZNF263_19887448_ChIP-Seq_K562_Human2.75744310
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74625084
10CLOCK_20551151_ChIP-Seq_293T_Human2.73505250
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70517260
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.50334226
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45570466
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.45394777
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.38494020
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34993700
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.32254347
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16749411
19KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.12114545
20SOX2_20726797_ChIP-Seq_SW620_Human2.03509930
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02062079
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00316601
23KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97200884
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.96679933
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96048297
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.95870797
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93207968
28CJUN_26792858_Chip-Seq_BT549_Human1.88792731
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.88040947
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86969109
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86870390
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80079761
33KLF4_18555785_ChIP-Seq_MESCs_Mouse1.78899917
34AR_21909140_ChIP-Seq_LNCAP_Human1.77028249
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75266075
36NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.72971152
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72756928
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.72501162
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.72461119
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71719021
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.71578406
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71453720
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69793534
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.68666823
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65938987
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.62311729
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61085717
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61079666
49GATA6_25053715_ChIP-Seq_YYC3_Human1.60525582
50TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60383695
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58348403
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56588151
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56331032
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56175092
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51840049
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.51180904
57GATA4_25053715_ChIP-Seq_YYC3_Human1.50597460
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50380446
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49947968
60ATF3_27146783_Chip-Seq_COLON_Human1.49285299
61EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.48940376
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47996616
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46612497
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45997177
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45935352
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.45810987
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.44556562
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.43983578
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42010320
70RACK7_27058665_Chip-Seq_MCF-7_Human1.39873336
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39414248
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38050944
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37492529
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37024490
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36163070
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36163070
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35206373
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35206373
79CHD1_26751641_Chip-Seq_LNCaP_Human1.34798128
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.33522061
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32579607
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29706334
83TFEB_21752829_ChIP-Seq_HELA_Human1.29032865
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28990130
85AR_21572438_ChIP-Seq_LNCaP_Human1.27804342
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27783251
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27387723
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26544210
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25191858
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24727889
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24438542
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23718745
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23297008
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22710647
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22099106
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22075882
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21422487
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21416207
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20539368
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20083617
101STAT1_17558387_ChIP-Seq_HELA_Human1.19825951
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18403650
103GBX2_23144817_ChIP-Seq_PC3_Human1.18051364
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17402602
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17328947
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16525129
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15158632
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14933001
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13992398
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.13490950
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.13470968
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.13373176
113CDX2_22108803_ChIP-Seq_LS180_Human1.13335048
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12647273
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11982495
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11953737
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11951549
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.11694922
119P53_22387025_ChIP-Seq_ESCs_Mouse1.10838338
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.10430723
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.10430723
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10182103
123RXR_22108803_ChIP-Seq_LS180_Human1.08663517
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08182778
125STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08124541
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.08106076
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07967816
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.07474613
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.07471251
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06826433
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06668177
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06601367
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05750016
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.05573272
135BRD4_25478319_ChIP-Seq_HGPS_Human1.05256842
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.05120226
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04974435
138SMAD4_21799915_ChIP-Seq_A2780_Human1.03809917
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02941488
140DCP1A_22483619_ChIP-Seq_HELA_Human1.02871373
141E2F1_21310950_ChIP-Seq_MCF-7_Human1.02537711
142GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02174825
143ERG_20517297_ChIP-Seq_VCAP_Human1.01987114
144UBF1/2_26484160_Chip-Seq_HMECs_Human1.01604397
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01257988
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00902971
147HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00864901
148SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00645032
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00536907
150EOMES_21245162_ChIP-Seq_HESCs_Human1.00524080
151TP63_23658742_ChIP-Seq_EP156T_Human1.00045286
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99241966
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99150477
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98901884
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98625884
156FUS_26573619_Chip-Seq_HEK293_Human0.97824754
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.95358620
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94802011
159VDR_24787735_ChIP-Seq_THP-1_Human0.94596314
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93105515
161CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92688963
162TP53_18474530_ChIP-ChIP_U2OS_Human0.92660393
163MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92454920
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92314373
165SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91873197
166CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91863511
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91518568
168PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91260808
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90801467
170HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90750558
171ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90688658
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88966839
173JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87916527
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86068088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.67405273
2MP0005360_urolithiasis3.60620291
3MP0003646_muscle_fatigue3.50801506
4MP0008004_abnormal_stomach_pH3.36476764
5MP0010234_abnormal_vibrissa_follicle3.25307195
6MP0008438_abnormal_cutaneous_collagen2.94617843
7MP0003705_abnormal_hypodermis_morpholog2.76905762
8MP0003950_abnormal_plasma_membrane2.75206259
9MP0004233_abnormal_muscle_weight2.68115439
10MP0000749_muscle_degeneration2.66608383
11MP0004264_abnormal_extraembryonic_tissu2.64858220
12MP0006054_spinal_hemorrhage2.60572116
13MP0002877_abnormal_melanocyte_morpholog2.50159776
14MP0004272_abnormal_basement_membrane2.47014739
15MP0004147_increased_porphyrin_level2.46008822
16MP0000490_abnormal_crypts_of2.38897011
17MP0002139_abnormal_hepatobiliary_system2.36921771
18MP0003718_maternal_effect2.36658068
19MP0001188_hyperpigmentation2.26841910
20MP0005451_abnormal_body_composition2.24947538
21MP0000747_muscle_weakness2.22341410
22MP0003806_abnormal_nucleotide_metabolis2.15942994
23MP0004087_abnormal_muscle_fiber2.12938731
24MP0001873_stomach_inflammation2.09793999
25MP0004036_abnormal_muscle_relaxation2.06723504
26MP0001986_abnormal_taste_sensitivity2.03532241
27MP0001666_abnormal_nutrient_absorption2.02413343
28MP0000759_abnormal_skeletal_muscle2.01682857
29MP0001663_abnormal_digestive_system1.96343651
30MP0004957_abnormal_blastocyst_morpholog1.94820763
31MP0002269_muscular_atrophy1.91436946
32MP0005623_abnormal_meninges_morphology1.89424854
33MP0003941_abnormal_skin_development1.87887042
34MP0000750_abnormal_muscle_regeneration1.77102929
35MP0004782_abnormal_surfactant_physiolog1.76429991
36MP0002796_impaired_skin_barrier1.75254289
37MP0002396_abnormal_hematopoietic_system1.73281939
38MP0004084_abnormal_cardiac_muscle1.72988083
39MP0004185_abnormal_adipocyte_glucose1.68892790
40MP0005084_abnormal_gallbladder_morpholo1.67780926
41MP0005330_cardiomyopathy1.66760076
42MP0005275_abnormal_skin_tensile1.63983328
43MP0005408_hypopigmentation1.62620555
44MP0010155_abnormal_intestine_physiology1.61006808
45MP0003693_abnormal_embryo_hatching1.58743642
46MP0005501_abnormal_skin_physiology1.58337268
47MP0005503_abnormal_tendon_morphology1.54580539
48MP0005085_abnormal_gallbladder_physiolo1.53738717
49MP0003183_abnormal_peptide_metabolism1.51026585
50MP0008875_abnormal_xenobiotic_pharmacok1.47907079
51MP0005365_abnormal_bile_salt1.47315150
52MP0004484_altered_response_of1.46092711
53MP0000733_abnormal_muscle_development1.45582706
54MP0001664_abnormal_digestion1.45300591
55MP0002876_abnormal_thyroid_physiology1.45160950
56MP0001119_abnormal_female_reproductive1.45058393
57MP0009250_abnormal_appendicular_skeleto1.44466081
58MP0004134_abnormal_chest_morphology1.44151492
59MP0008932_abnormal_embryonic_tissue1.44103264
60MP0002735_abnormal_chemical_nociception1.43499524
61MP0009384_cardiac_valve_regurgitation1.43254829
62MP0000015_abnormal_ear_pigmentation1.41486004
63MP0000343_altered_response_to1.40116014
64MP0005381_digestive/alimentary_phenotyp1.38015836
65MP0000516_abnormal_urinary_system1.35801576
66MP0005367_renal/urinary_system_phenotyp1.35801576
67MP0005369_muscle_phenotype1.35579499
68MP0003656_abnormal_erythrocyte_physiolo1.33850334
69MP0002009_preneoplasia1.32432581
70MP0001730_embryonic_growth_arrest1.32168972
71MP0000013_abnormal_adipose_tissue1.31861401
72MP0003221_abnormal_cardiomyocyte_apopto1.31631604
73MP0005620_abnormal_muscle_contractility1.30711219
74MP0005266_abnormal_metabolism1.30561447
75MP0001661_extended_life_span1.28839742
76MP0005023_abnormal_wound_healing1.28535874
77MP0008007_abnormal_cellular_replicative1.26777473
78MP0002736_abnormal_nociception_after1.26408017
79MP0003866_abnormal_defecation1.22856379
80MP0010630_abnormal_cardiac_muscle1.21334484
81MP0003111_abnormal_nucleus_morphology1.20466076
82MP0003436_decreased_susceptibility_to1.18008332
83MP0003943_abnormal_hepatobiliary_system1.17055353
84MP0002972_abnormal_cardiac_muscle1.15948611
85MP0010030_abnormal_orbit_morphology1.15418072
86MP0004270_analgesia1.13592488
87MP0001533_abnormal_skeleton_physiology1.12918660
88MP0000762_abnormal_tongue_morphology1.10689382
89MP0001299_abnormal_eye_distance/1.09599542
90MP0003453_abnormal_keratinocyte_physiol1.08424822
91MP0000566_synostosis1.05940282
92MP0004145_abnormal_muscle_electrophysio1.05909529
93MP0003091_abnormal_cell_migration1.05708326
94MP0001764_abnormal_homeostasis1.05690258
95MP0002108_abnormal_muscle_morphology1.04803023
96MP0003123_paternal_imprinting1.04612940
97MP0001849_ear_inflammation1.04546354
98MP0002148_abnormal_hypersensitivity_rea1.04416028
99MP0000538_abnormal_urinary_bladder1.03445851
100MP0003279_aneurysm1.02950882
101MP0000477_abnormal_intestine_morphology0.99336382
102MP0005083_abnormal_biliary_tract0.98931792
103MP0002933_joint_inflammation0.98337134
104MP0000003_abnormal_adipose_tissue0.97894425
105MP0005646_abnormal_pituitary_gland0.96238881
106MP0006138_congestive_heart_failure0.96165062
107MP0005390_skeleton_phenotype0.95235296
108MP0000163_abnormal_cartilage_morphology0.93944338
109MP0003566_abnormal_cell_adhesion0.93927279
110MP0002086_abnormal_extraembryonic_tissu0.93445189
111MP0009672_abnormal_birth_weight0.93136436
112MP0010368_abnormal_lymphatic_system0.92789582
113MP0000751_myopathy0.92623230
114MP0002163_abnormal_gland_morphology0.92561767
115MP0003186_abnormal_redox_activity0.91658609
116MP0008260_abnormal_autophagy0.90578046
117MP0005165_increased_susceptibility_to0.90309812
118MP0010307_abnormal_tumor_latency0.89205077
119MP0002115_abnormal_skeleton_extremities0.88709577
120MP0009785_altered_susceptibility_to0.88679318
121MP0005397_hematopoietic_system_phenotyp0.87722211
122MP0001545_abnormal_hematopoietic_system0.87722211
123MP0002896_abnormal_bone_mineralization0.87475818
124MP0001672_abnormal_embryogenesis/_devel0.87373502
125MP0005380_embryogenesis_phenotype0.87373502
126MP0002080_prenatal_lethality0.86923172
127MP0002282_abnormal_trachea_morphology0.86772461
128MP0004858_abnormal_nervous_system0.86715810
129MP0003984_embryonic_growth_retardation0.86701900
130MP0003077_abnormal_cell_cycle0.86490986
131MP0003828_pulmonary_edema0.86325453
132MP0000350_abnormal_cell_proliferation0.85469441
133MP0000467_abnormal_esophagus_morphology0.84767468
134MP0002249_abnormal_larynx_morphology0.84536124
135MP0005464_abnormal_platelet_physiology0.84431936
136MP0001915_intracranial_hemorrhage0.83476574
137MP0005666_abnormal_adipose_tissue0.83435743
138MP0000462_abnormal_digestive_system0.83422981
139MP0003699_abnormal_female_reproductive0.83073182
140MP0003191_abnormal_cellular_cholesterol0.82470522
141MP0009379_abnormal_foot_pigmentation0.82444801
142MP0002113_abnormal_skeleton_development0.82031960
143MP0002060_abnormal_skin_morphology0.81404940
144MP0002160_abnormal_reproductive_system0.81221797
145MP0005376_homeostasis/metabolism_phenot0.80782081
146MP0002106_abnormal_muscle_physiology0.80468142
147MP0002088_abnormal_embryonic_growth/wei0.80335482
148MP0005375_adipose_tissue_phenotype0.79728333
149MP0001697_abnormal_embryo_size0.79474556
150MP0005395_other_phenotype0.79053249
151MP0005257_abnormal_intraocular_pressure0.78058733
152MP0002085_abnormal_embryonic_tissue0.76762373
153MP0000858_altered_metastatic_potential0.76612713
154MP0008057_abnormal_DNA_replication0.76320789
155MP0004197_abnormal_fetal_growth/weight/0.76252803
156MP0002084_abnormal_developmental_patter0.75941195
157MP0000678_abnormal_parathyroid_gland0.75906478
158MP0002109_abnormal_limb_morphology0.75723233
159MP0009333_abnormal_splenocyte_physiolog0.75590908
160MP0005621_abnormal_cell_physiology0.75482568
161MP0006036_abnormal_mitochondrial_physio0.75466327
162MP0001243_abnormal_dermal_layer0.75110376
163MP0001919_abnormal_reproductive_system0.74656297
164MP0005076_abnormal_cell_differentiation0.74639830
165MP0009780_abnormal_chondrocyte_physiolo0.71681569
166MP0003252_abnormal_bile_duct0.71630057
167MP0005174_abnormal_tail_pigmentation0.70037433
168MP0001270_distended_abdomen0.69365933
169MP0002332_abnormal_exercise_endurance0.67549916
170MP0010352_gastrointestinal_tract_polyps0.67100825
171MP0001542_abnormal_bone_strength0.66567759

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)5.71047543
2Exercise-induced myalgia (HP:0003738)5.24734785
3Cupped ribs (HP:0000887)5.14020786
4Exercise-induced muscle cramps (HP:0003710)4.68356393
5Centrally nucleated skeletal muscle fibers (HP:0003687)4.18523465
6Calcaneovalgus deformity (HP:0001848)4.17751527
7Round ear (HP:0100830)4.17683407
8Flat capital femoral epiphysis (HP:0003370)4.09996119
9Myopathic facies (HP:0002058)3.88388050
10Epiphyseal dysplasia (HP:0002656)3.78901162
11Premature rupture of membranes (HP:0001788)3.63895530
12Type 2 muscle fiber atrophy (HP:0003554)3.62219148
13EMG: myopathic abnormalities (HP:0003458)3.58771143
14Deformed tarsal bones (HP:0008119)3.56982304
15Flat acetabular roof (HP:0003180)3.54881541
16Abnormal tarsal ossification (HP:0008369)3.41688032
17Neck muscle weakness (HP:0000467)3.39238068
18Abnormality of skeletal muscle fiber size (HP:0012084)3.36044948
19Abnormality of the ischium (HP:0003174)3.30317608
20Abnormal foot bone ossification (HP:0010675)3.29072881
21Rhabdomyolysis (HP:0003201)3.27944586
22Fatigable weakness (HP:0003473)3.27909462
23Abnormality of the neuromuscular junction (HP:0003398)3.27909462
24Distal lower limb muscle weakness (HP:0009053)3.24943436
25Myoglobinuria (HP:0002913)3.17993352
26Nemaline bodies (HP:0003798)3.15049937
27Abnormality of the calcaneus (HP:0008364)3.05757011
28Fetal akinesia sequence (HP:0001989)3.03158601
29Delayed epiphyseal ossification (HP:0002663)3.00062963
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99442583
31Long clavicles (HP:0000890)2.97387123
32Breech presentation (HP:0001623)2.95439276
33Muscle fiber atrophy (HP:0100295)2.95202747
34Muscle hypertrophy of the lower extremities (HP:0008968)2.94868819
35Limb-girdle muscle atrophy (HP:0003797)2.94396544
36Muscle fiber splitting (HP:0003555)2.91328112
37Rimmed vacuoles (HP:0003805)2.90063963
38Vitreoretinal degeneration (HP:0000655)2.90042565
39Muscle stiffness (HP:0003552)2.89620474
40Hyporeflexia of lower limbs (HP:0002600)2.86005808
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85511283
42Chromsome breakage (HP:0040012)2.84641255
43Abnormality of the calf musculature (HP:0001430)2.84370963
44Muscle fiber inclusion bodies (HP:0100299)2.83468123
45Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.83057017
46Abnormality of femoral epiphyses (HP:0006499)2.83057017
47Cystic hygroma (HP:0000476)2.82560718
48Weak cry (HP:0001612)2.81134297
49Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.80118258
50Reduced antithrombin III activity (HP:0001976)2.77726429
51Calf muscle hypertrophy (HP:0008981)2.77062012
52Trismus (HP:0000211)2.77054237
53Short femoral neck (HP:0100864)2.75329634
54Increased variability in muscle fiber diameter (HP:0003557)2.72916089
55Abnormality of the epiphysis of the femoral head (HP:0010574)2.70456521
56Autoimmune thrombocytopenia (HP:0001973)2.70047631
57Spinal rigidity (HP:0003306)2.69448896
58Nonprogressive disorder (HP:0003680)2.67849797
59Metaphyseal irregularity (HP:0003025)2.65305931
60Ileus (HP:0002595)2.63840139
61Adrenal hypoplasia (HP:0000835)2.59546943
62Right ventricular cardiomyopathy (HP:0011663)2.59445014
63Hypoplastic ischia (HP:0003175)2.59062193
64Stillbirth (HP:0003826)2.58879663
65Protrusio acetabuli (HP:0003179)2.57951826
66Pelvic girdle muscle weakness (HP:0003749)2.57864932
67Abnormality of the femoral head (HP:0003368)2.55593562
68Shoulder girdle muscle weakness (HP:0003547)2.54549829
69Thrombocytosis (HP:0001894)2.54377329
70Type I transferrin isoform profile (HP:0003642)2.52678818
71Ulnar deviation of the wrist (HP:0003049)2.52643945
72Lower limb amyotrophy (HP:0007210)2.51814137
73Genu varum (HP:0002970)2.48446101
74Abnormality of the hip-girdle musculature (HP:0001445)2.41078111
75Abnormality of the musculature of the pelvis (HP:0001469)2.41078111
76Pterygium (HP:0001059)2.37867983
77Abnormality of carpal bone ossification (HP:0006257)2.35979584
78Aplasia of the musculature (HP:0100854)2.34034174
79Amniotic constriction ring (HP:0009775)2.32564626
80Abnormality of placental membranes (HP:0011409)2.32564626
81Progressive muscle weakness (HP:0003323)2.29812856
82Popliteal pterygium (HP:0009756)2.28337739
83Achilles tendon contracture (HP:0001771)2.27773611
84Difficulty running (HP:0009046)2.26774395
85Thin ribs (HP:0000883)2.26091291
86Cervical subluxation (HP:0003308)2.23430760
87Hypoplastic ilia (HP:0000946)2.22591617
88Distal arthrogryposis (HP:0005684)2.21730993
89Abnormality of the left ventricular outflow tract (HP:0011103)2.19360825
90Subaortic stenosis (HP:0001682)2.19360825
91Type 1 muscle fiber predominance (HP:0003803)2.17045630
92Increased connective tissue (HP:0009025)2.16506982
93Renal cortical cysts (HP:0000803)2.15396259
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.15124187
95Osteolytic defects of the hand bones (HP:0009699)2.15124187
96Aplasia/hypoplasia of the femur (HP:0005613)2.14920266
97Ventricular tachycardia (HP:0004756)2.14484698
98Abnormality of the Achilles tendon (HP:0005109)2.13550900
99Short nail (HP:0001799)2.12041721
100Mesomelia (HP:0003027)2.08614843
101Limb-girdle muscle weakness (HP:0003325)2.08581125
102Metatarsus adductus (HP:0001840)2.08139025
103Neonatal short-limb short stature (HP:0008921)2.05229666
104Hip contracture (HP:0003273)2.04718075
105Mildly elevated creatine phosphokinase (HP:0008180)2.03237972
106Flattened epiphyses (HP:0003071)2.01010320
107Slender build (HP:0001533)2.00753077
108Abnormal finger flexion creases (HP:0006143)2.00416266
109Curly hair (HP:0002212)1.98984133
110Gowers sign (HP:0003391)1.98562851
111Abnormality of incisor morphology (HP:0011063)1.98433211
112Distal lower limb amyotrophy (HP:0008944)1.97780385
113Frequent falls (HP:0002359)1.97671531
114Asymmetric septal hypertrophy (HP:0001670)1.97281698
115Mild short stature (HP:0003502)1.97159828
116Areflexia of lower limbs (HP:0002522)1.94203205
117Vertebral compression fractures (HP:0002953)1.92543285
118Easy fatigability (HP:0003388)1.91837865
119Difficulty climbing stairs (HP:0003551)1.91822277
120Abnormal protein glycosylation (HP:0012346)1.89963852
121Abnormal glycosylation (HP:0012345)1.89963852
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89963852
123Abnormal protein N-linked glycosylation (HP:0012347)1.89963852
124Spinal cord lesions (HP:0100561)1.89770186
125Syringomyelia (HP:0003396)1.89770186
126Beaking of vertebral bodies (HP:0004568)1.89427210
127Aortic aneurysm (HP:0004942)1.87886259
128Bradycardia (HP:0001662)1.87703590
129Absent phalangeal crease (HP:0006109)1.86808420
130Coxa vara (HP:0002812)1.86507888
131Tetraparesis (HP:0002273)1.85167666
132Fragile skin (HP:0001030)1.84955308
133Abnormality of the vertebral endplates (HP:0005106)1.84001298
134Papillary thyroid carcinoma (HP:0002895)1.83970561
135Enlarged epiphyses (HP:0010580)1.83925336
136Scapular winging (HP:0003691)1.83781670
137Atrophic scars (HP:0001075)1.83497834
138Irregular vertebral endplates (HP:0003301)1.79994202
139Generalized muscle weakness (HP:0003324)1.79442678
140Abnormal hair whorl (HP:0010721)1.78981632
141Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78511307
142Hypoplastic scapulae (HP:0000882)1.78511307
143Lipoatrophy (HP:0100578)1.78170755
144Thoracolumbar scoliosis (HP:0002944)1.77858314
145Thyroid carcinoma (HP:0002890)1.77396701
146Malignant hyperthermia (HP:0002047)1.76965871
147Ragged-red muscle fibers (HP:0003200)1.76934344
148Proximal tubulopathy (HP:0000114)1.76018133
149Bulbar palsy (HP:0001283)1.75994176
150Limited hip movement (HP:0008800)1.75777802
151Toxemia of pregnancy (HP:0100603)1.74438331
152Sudden death (HP:0001699)1.72926909
153Small epiphyses (HP:0010585)1.72433799
15411 pairs of ribs (HP:0000878)1.72412831
155Ovoid vertebral bodies (HP:0003300)1.72085033
156True hermaphroditism (HP:0010459)1.71364991
157Neoplasm of the rectum (HP:0100743)1.70697302
158Aplastic anemia (HP:0001915)1.70325947
159Back pain (HP:0003418)1.69573884
160Increased mean platelet volume (HP:0011877)1.69054726
161Dilated cardiomyopathy (HP:0001644)1.69027654
162Reduced subcutaneous adipose tissue (HP:0003758)1.68798511
163Vertebral hypoplasia (HP:0008417)1.67971029
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.67971029
165Bundle branch block (HP:0011710)1.67558003
166Abnormal delivery (HP:0001787)1.67343406
167Abnormalities of placenta or umbilical cord (HP:0001194)1.66768747
168Aortic dissection (HP:0002647)1.66432524
169Gout (HP:0001997)1.65418755
170Biliary tract neoplasm (HP:0100574)1.62054516
171Upper limb amyotrophy (HP:0009129)1.60894656
172Distal upper limb amyotrophy (HP:0007149)1.60894656
173Arterial tortuosity (HP:0005116)1.59882379
174Abnormal platelet volume (HP:0011876)1.58772376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.20097748
2FRK3.96861267
3TTN3.70888803
4EPHA23.45929247
5LATS13.01853742
6STK38L2.99905166
7ERBB32.78803568
8PRPF4B2.75398916
9CASK2.65886559
10AKT32.64694803
11MET2.56880222
12PBK2.22252502
13TRPM72.22096260
14STK242.12976039
15PIM22.07840186
16PRKG22.06432641
17BRAF2.04409619
18NUAK11.99363831
19SGK21.97656192
20BMPR21.96066163
21MAP3K121.94900215
22ERBB41.88542403
23PAK41.84755042
24PHKG21.74701007
25PHKG11.74701007
26MYLK1.61503552
27EEF2K1.51504627
28PTK21.50158214
29PDGFRA1.48587910
30RIPK11.46133754
31ARAF1.43855891
32NME11.43754515
33RAF11.41972779
34TESK11.40119289
35SMG11.36678541
36SGK31.36448954
37MAP3K141.35310829
38MST41.34780421
39SIK31.32787353
40LATS21.31409769
41LIMK11.29293113
42OBSCN1.26755116
43LMTK21.22122494
44CDK81.21951813
45ZAK1.21214197
46MAP3K31.20392155
47TAOK31.16927576
48MAP2K71.15588724
49PDK21.14274887
50NEK91.12943750
51STK31.10266493
52MAP3K101.09393591
53MAP3K61.08510373
54CDC71.05097609
55SRPK11.03555193
56BMX1.03343492
57MOS1.00975482
58MAP2K10.97830958
59ERN10.95011285
60PIK3CG0.91896859
61MAPKAPK30.91635146
62CDK120.91266836
63BUB10.91215217
64TAOK10.90117918
65MAP3K80.89426690
66DMPK0.88898003
67SGK4940.88839496
68SGK2230.88839496
69PIM10.88792252
70TSSK60.88029969
71MKNK10.87681553
72RPS6KB20.86786850
73MAP3K20.86448372
74IRAK40.86167577
75IRAK30.85239141
76RPS6KA40.84948268
77NME20.83646846
78PIK3CA0.81249329
79KSR10.79528623
80CHUK0.79257462
81KSR20.76480801
82EPHB10.74574732
83EIF2AK30.74396764
84BMPR1B0.73939401
85PLK40.73899768
86NTRK10.71497014
87DYRK30.70643587
88DDR20.70613446
89NEK10.69732286
90PINK10.68409858
91CAMK2G0.67852988
92BCR0.67006816
93PAK10.64995294
94CAMKK20.64978060
95TAOK20.63790936
96AKT20.63743647
97YES10.63381468
98MAP3K90.62630976
99MST1R0.62219814
100RPS6KB10.61168780
101PLK20.61082916
102FLT30.60802346
103RPS6KA20.60036950
104BRSK20.57696150
105MAPKAPK50.57514676
106MKNK20.57250165
107SCYL20.56393006
108MAP2K60.56350028
109ILK0.56323875
110PLK10.56308648
111ICK0.55147023
112JAK30.52360855
113EIF2AK20.51626147
114TEC0.51438339
115FER0.50312890
116RPS6KA60.50191987
117STK380.50013214
118RPS6KC10.49852974
119RPS6KL10.49852974
120CDK70.49796844
121TESK20.49214435
122MATK0.48876877
123MAP3K10.46366277
124MAP3K70.46053322
125KIT0.44559863
126BRSK10.43601555
127MELK0.43551418
128NLK0.43061569
129ROCK10.42699732
130MAPK40.42269812
131PAK20.41511130
132ADRBK20.41088763
133MAP2K30.41067068
134CAMK2D0.39649757
135PRKAA20.39575818
136FGFR40.39362090
137EPHB20.38779022
138PLK30.38731441
139CDK60.37533814
140IKBKB0.37008750
141TRIB30.36843724
142NEK20.35644848
143PRKAA10.35387257
144ALK0.34744493
145MTOR0.34531170
146IKBKE0.34012217
147ABL20.33190971
148PRKCI0.32878200
149MAPK130.32130945
150CHEK20.30789166
151MAP3K110.30624380
152TTK0.29558807
153EIF2AK10.28744279
154STK100.27951157
155MAPKAPK20.27727352
156AURKB0.27372365

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.57811482
2Galactose metabolism_Homo sapiens_hsa000523.29578762
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.04199239
4Starch and sucrose metabolism_Homo sapiens_hsa005003.01685267
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.93839488
6Sulfur metabolism_Homo sapiens_hsa009202.92024393
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.63994759
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57719654
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51421476
10Biosynthesis of amino acids_Homo sapiens_hsa012302.32417940
11Mineral absorption_Homo sapiens_hsa049782.30403707
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24224448
13Fat digestion and absorption_Homo sapiens_hsa049752.17805977
14Renin-angiotensin system_Homo sapiens_hsa046142.05232953
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01728127
16Fructose and mannose metabolism_Homo sapiens_hsa000511.95101628
17Thyroid cancer_Homo sapiens_hsa052161.94137269
18Arginine biosynthesis_Homo sapiens_hsa002201.76921250
19Ovarian steroidogenesis_Homo sapiens_hsa049131.66635338
20Circadian rhythm_Homo sapiens_hsa047101.62406422
21Base excision repair_Homo sapiens_hsa034101.61342255
22Vitamin digestion and absorption_Homo sapiens_hsa049771.60502876
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59945080
24Cell cycle_Homo sapiens_hsa041101.58691637
25Arachidonic acid metabolism_Homo sapiens_hsa005901.57079477
26Sphingolipid metabolism_Homo sapiens_hsa006001.55474773
27Glutathione metabolism_Homo sapiens_hsa004801.51393634
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51326602
29Folate biosynthesis_Homo sapiens_hsa007901.48154792
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.47512655
31Protein digestion and absorption_Homo sapiens_hsa049741.40300018
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36078173
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28741289
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25351575
35Caffeine metabolism_Homo sapiens_hsa002321.22580738
36Insulin signaling pathway_Homo sapiens_hsa049101.20655164
37Mismatch repair_Homo sapiens_hsa034301.20103964
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15299634
39RNA degradation_Homo sapiens_hsa030181.14403469
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11743607
41p53 signaling pathway_Homo sapiens_hsa041151.10473357
42Chemical carcinogenesis_Homo sapiens_hsa052041.09134696
43Fanconi anemia pathway_Homo sapiens_hsa034601.06233369
44N-Glycan biosynthesis_Homo sapiens_hsa005101.04087962
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02817009
46Glucagon signaling pathway_Homo sapiens_hsa049221.01669848
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01323679
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99542564
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97732285
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.97615142
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.97215362
52Purine metabolism_Homo sapiens_hsa002300.96758082
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95466900
54Adherens junction_Homo sapiens_hsa045200.93828338
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93798872
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93252368
57Proteoglycans in cancer_Homo sapiens_hsa052050.90762899
58Shigellosis_Homo sapiens_hsa051310.90725964
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90100793
60Amoebiasis_Homo sapiens_hsa051460.89773707
61Olfactory transduction_Homo sapiens_hsa047400.88145699
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85402476
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85193687
64Small cell lung cancer_Homo sapiens_hsa052220.84856140
65Basal transcription factors_Homo sapiens_hsa030220.83998958
66Chronic myeloid leukemia_Homo sapiens_hsa052200.83631019
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83094582
68Other glycan degradation_Homo sapiens_hsa005110.81461126
69Proteasome_Homo sapiens_hsa030500.81421361
70Fatty acid elongation_Homo sapiens_hsa000620.81172610
71Retinol metabolism_Homo sapiens_hsa008300.80573580
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80091358
73Homologous recombination_Homo sapiens_hsa034400.77957171
74Histidine metabolism_Homo sapiens_hsa003400.77896473
75Endometrial cancer_Homo sapiens_hsa052130.76696785
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75854260
77AMPK signaling pathway_Homo sapiens_hsa041520.75115562
78Pentose phosphate pathway_Homo sapiens_hsa000300.74789501
79DNA replication_Homo sapiens_hsa030300.69819678
80RNA transport_Homo sapiens_hsa030130.69072972
81GnRH signaling pathway_Homo sapiens_hsa049120.68748666
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68381557
83Pancreatic cancer_Homo sapiens_hsa052120.67910830
84Salmonella infection_Homo sapiens_hsa051320.67650776
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.65091017
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65070403
87Pyrimidine metabolism_Homo sapiens_hsa002400.64647818
88Sulfur relay system_Homo sapiens_hsa041220.62402748
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.61558092
90Bladder cancer_Homo sapiens_hsa052190.57365952
91Phenylalanine metabolism_Homo sapiens_hsa003600.55069863
92ECM-receptor interaction_Homo sapiens_hsa045120.53787239
93Hippo signaling pathway_Homo sapiens_hsa043900.53267015
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.52688927
95Non-homologous end-joining_Homo sapiens_hsa034500.51052448
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50923841
97Apoptosis_Homo sapiens_hsa042100.50492074
98Hepatitis B_Homo sapiens_hsa051610.48585749
99Prolactin signaling pathway_Homo sapiens_hsa049170.48413896
100Renal cell carcinoma_Homo sapiens_hsa052110.47764973
101Selenocompound metabolism_Homo sapiens_hsa004500.47669097
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47662056
103Insulin resistance_Homo sapiens_hsa049310.47128840
104MicroRNAs in cancer_Homo sapiens_hsa052060.46926341
105Endocytosis_Homo sapiens_hsa041440.45985889
106Protein export_Homo sapiens_hsa030600.45633119
107Leishmaniasis_Homo sapiens_hsa051400.45630109
108Dilated cardiomyopathy_Homo sapiens_hsa054140.45132884
109Linoleic acid metabolism_Homo sapiens_hsa005910.44657172
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43678954
111Fatty acid degradation_Homo sapiens_hsa000710.43306915
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43207748
113TGF-beta signaling pathway_Homo sapiens_hsa043500.42574236
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42130724
115Influenza A_Homo sapiens_hsa051640.42056769
116Legionellosis_Homo sapiens_hsa051340.41575264
117Pancreatic secretion_Homo sapiens_hsa049720.41004181
118FoxO signaling pathway_Homo sapiens_hsa040680.40893298
119Metabolic pathways_Homo sapiens_hsa011000.40264078
120mRNA surveillance pathway_Homo sapiens_hsa030150.40259484
121Non-small cell lung cancer_Homo sapiens_hsa052230.40156193
122Viral carcinogenesis_Homo sapiens_hsa052030.39756949
123Peroxisome_Homo sapiens_hsa041460.38016986
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37874427
125Gap junction_Homo sapiens_hsa045400.36990859
126Fatty acid metabolism_Homo sapiens_hsa012120.36845671
127Glioma_Homo sapiens_hsa052140.35618308
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35267218
129Vitamin B6 metabolism_Homo sapiens_hsa007500.34175696
130Carbon metabolism_Homo sapiens_hsa012000.34112512
131Pyruvate metabolism_Homo sapiens_hsa006200.33534725
132Nitrogen metabolism_Homo sapiens_hsa009100.33339471
133ABC transporters_Homo sapiens_hsa020100.33170214
134Phagosome_Homo sapiens_hsa041450.32860143
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32652772
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32530157
137Nucleotide excision repair_Homo sapiens_hsa034200.32061363
138Thyroid hormone synthesis_Homo sapiens_hsa049180.31244650
139Focal adhesion_Homo sapiens_hsa045100.30234040
140Platelet activation_Homo sapiens_hsa046110.29921455
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28767330
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25724030
143Bile secretion_Homo sapiens_hsa049760.25001864
144Vibrio cholerae infection_Homo sapiens_hsa051100.23880116
145Hematopoietic cell lineage_Homo sapiens_hsa046400.23509481
146Arginine and proline metabolism_Homo sapiens_hsa003300.22644319
147Tight junction_Homo sapiens_hsa045300.22475163
148Malaria_Homo sapiens_hsa051440.21859471
149Melanoma_Homo sapiens_hsa052180.21168348
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.20826420
151Hepatitis C_Homo sapiens_hsa051600.18807467

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