MCTS2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.54633754
2DNA strand elongation involved in DNA replication (GO:0006271)4.49595214
3DNA strand elongation (GO:0022616)4.35870600
4nuclear pore complex assembly (GO:0051292)4.34708814
5telomere maintenance via semi-conservative replication (GO:0032201)4.24892064
6DNA topological change (GO:0006265)4.18467535
7establishment of integrated proviral latency (GO:0075713)4.11054252
8nuclear pore organization (GO:0006999)4.07013781
9mitotic sister chromatid segregation (GO:0000070)4.05787212
10CENP-A containing nucleosome assembly (GO:0034080)3.93847993
11sister chromatid segregation (GO:0000819)3.88977281
12chromatin remodeling at centromere (GO:0031055)3.81473365
13DNA ligation (GO:0006266)3.80359145
14mitotic nuclear envelope disassembly (GO:0007077)3.61731638
15telomere maintenance via recombination (GO:0000722)3.61617623
16mitotic recombination (GO:0006312)3.60566866
17protein localization to chromosome, centromeric region (GO:0071459)3.55022886
18regulation of mitochondrial translation (GO:0070129)3.49918189
19termination of RNA polymerase II transcription (GO:0006369)3.46205901
20proteasome assembly (GO:0043248)3.45178567
21nuclear envelope reassembly (GO:0031468)3.42890611
22mitotic nuclear envelope reassembly (GO:0007084)3.42890611
23ribosome biogenesis (GO:0042254)3.40465430
24mitotic chromosome condensation (GO:0007076)3.38680135
25DNA catabolic process, exonucleolytic (GO:0000738)3.35028674
26viral mRNA export from host cell nucleus (GO:0046784)3.33866015
27mitotic sister chromatid cohesion (GO:0007064)3.33204650
28membrane disassembly (GO:0030397)3.31342405
29nuclear envelope disassembly (GO:0051081)3.31342405
30mitotic metaphase plate congression (GO:0007080)3.31064080
31purine nucleobase biosynthetic process (GO:0009113)3.30973858
32DNA double-strand break processing (GO:0000729)3.28060843
33protein localization to kinetochore (GO:0034501)3.28015565
34regulation of centriole replication (GO:0046599)3.26253369
35tRNA aminoacylation for protein translation (GO:0006418)3.26030135
36kinetochore organization (GO:0051383)3.25953336
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25837348
38DNA replication-independent nucleosome organization (GO:0034724)3.25192604
39DNA replication-independent nucleosome assembly (GO:0006336)3.25192604
40DNA replication initiation (GO:0006270)3.19063863
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18349038
42histone H2A acetylation (GO:0043968)3.17650621
43peptidyl-arginine omega-N-methylation (GO:0035247)3.17298820
44IMP biosynthetic process (GO:0006188)3.16613495
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16250517
46amino acid activation (GO:0043038)3.15930667
47tRNA aminoacylation (GO:0043039)3.15930667
48DNA replication-dependent nucleosome assembly (GO:0006335)3.15855993
49DNA replication-dependent nucleosome organization (GO:0034723)3.15855993
50pore complex assembly (GO:0046931)3.15841128
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.15752901
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15752901
53DNA replication checkpoint (GO:0000076)3.15662208
54histone exchange (GO:0043486)3.13705037
55deoxyribonucleotide biosynthetic process (GO:0009263)3.11417469
56ribosome assembly (GO:0042255)3.11031540
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.08611901
58substrate-independent telencephalic tangential migration (GO:0021826)3.08611901
59mitochondrial RNA metabolic process (GO:0000959)3.07746286
60nucleobase biosynthetic process (GO:0046112)3.07014034
61telomere maintenance via telomere lengthening (GO:0010833)3.06043566
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05715479
63spindle checkpoint (GO:0031577)3.05507984
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04343971
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.03979180
66regulation of translational termination (GO:0006449)3.02367212
67RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01730085
68mRNA splicing, via spliceosome (GO:0000398)3.01730085
69establishment of viral latency (GO:0019043)3.01357625
70RNA splicing, via transesterification reactions (GO:0000375)3.01334157
71spliceosomal snRNP assembly (GO:0000387)2.99820892
72regulation of double-strand break repair via homologous recombination (GO:0010569)2.97676838
73DNA damage response, detection of DNA damage (GO:0042769)2.97539382
74ATP-dependent chromatin remodeling (GO:0043044)2.97172447
75negative regulation of mRNA processing (GO:0050686)2.96623156
76regulation of helicase activity (GO:0051095)2.96092969
77negative regulation of chromosome segregation (GO:0051985)2.95818738
78mitotic spindle checkpoint (GO:0071174)2.92882963
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92845300
80formation of translation preinitiation complex (GO:0001731)2.92325001
81transcription-coupled nucleotide-excision repair (GO:0006283)2.90477269
82base-excision repair (GO:0006284)2.89935744
83kinetochore assembly (GO:0051382)2.89271246
84negative regulation of mitotic sister chromatid separation (GO:2000816)2.88050451
85negative regulation of sister chromatid segregation (GO:0033046)2.88050451
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88050451
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88050451
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88050451
89spindle assembly checkpoint (GO:0071173)2.87915827
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86679395
91mitotic spindle assembly checkpoint (GO:0007094)2.86437945
92DNA-templated transcription, termination (GO:0006353)2.86398065
93de novo protein folding (GO:0006458)2.84138164
94metaphase plate congression (GO:0051310)2.84038281
95regulation of sister chromatid cohesion (GO:0007063)2.83614372
96double-strand break repair via nonhomologous end joining (GO:0006303)2.82661444
97non-recombinational repair (GO:0000726)2.82661444
98de novo posttranslational protein folding (GO:0051084)2.81577018
99L-serine metabolic process (GO:0006563)2.80761854
100protein localization to chromosome (GO:0034502)2.80697728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74213309
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15587802
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99612683
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.99084996
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.92250593
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.63633113
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43245589
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.41281864
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29932873
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23091454
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10447968
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.98412849
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.91943333
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74485741
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70976217
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67628262
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67169240
18DCP1A_22483619_ChIP-Seq_HELA_Human2.62852194
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57803519
20XRN2_22483619_ChIP-Seq_HELA_Human2.55922062
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44549173
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43405013
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39946081
24GABP_19822575_ChIP-Seq_HepG2_Human2.36642457
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36628909
26VDR_23849224_ChIP-Seq_CD4+_Human2.32836547
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32287180
28ELK1_19687146_ChIP-ChIP_HELA_Human2.28552927
29TTF2_22483619_ChIP-Seq_HELA_Human2.21105563
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16030102
31FOXP3_21729870_ChIP-Seq_TREG_Human2.13007441
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06054605
33E2F1_21310950_ChIP-Seq_MCF-7_Human2.05356728
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.02970030
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02946726
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99901922
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99677469
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98227036
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97306016
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97035632
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91891531
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89657353
43AR_21909140_ChIP-Seq_LNCAP_Human1.88261888
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.86330075
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82554042
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77501757
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.74785716
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73839730
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66611105
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64809968
51CIITA_25753668_ChIP-Seq_RAJI_Human1.64285426
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62892022
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59727883
54KDM5A_27292631_Chip-Seq_BREAST_Human1.56313075
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.55636702
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46490000
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44270714
58MYC_18940864_ChIP-ChIP_HL60_Human1.40299437
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38697827
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35663613
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33590464
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33110719
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31909774
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31670151
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28152507
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.21061232
67TFEB_21752829_ChIP-Seq_HELA_Human1.18698286
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17636149
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16644030
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15944169
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15448825
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10810200
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.09142989
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.08128392
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06889814
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04195042
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01094283
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99296821
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98492678
80ZNF263_19887448_ChIP-Seq_K562_Human0.97844665
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95600892
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.92421550
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91947621
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.91826376
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.90782687
86TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90706899
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89987452
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89136793
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.88129326
90MYC_22102868_ChIP-Seq_BL_Human0.85536400
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85048045
92ZNF274_21170338_ChIP-Seq_K562_Hela0.84894142
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83246486
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82730078
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.82530757
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.80557297
97EWS_26573619_Chip-Seq_HEK293_Human0.80202111
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77930309
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75674721
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75620011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.84430997
2MP0003693_abnormal_embryo_hatching4.53857849
3MP0003111_abnormal_nucleus_morphology4.33539457
4MP0008058_abnormal_DNA_repair4.24745161
5MP0008057_abnormal_DNA_replication3.75784953
6MP0004957_abnormal_blastocyst_morpholog3.57657233
7MP0003077_abnormal_cell_cycle3.53563364
8MP0008932_abnormal_embryonic_tissue3.13815233
9MP0008007_abnormal_cellular_replicative2.64497038
10MP0003221_abnormal_cardiomyocyte_apopto2.40541397
11MP0003786_premature_aging2.29696781
12MP0002822_catalepsy2.20471623
13MP0009697_abnormal_copulation2.19973273
14MP0001529_abnormal_vocalization2.19291467
15MP0005623_abnormal_meninges_morphology2.06069072
16MP0000372_irregular_coat_pigmentation2.01954520
17MP0008789_abnormal_olfactory_epithelium1.91154613
18MP0001730_embryonic_growth_arrest1.85686220
19MP0000350_abnormal_cell_proliferation1.78668542
20MP0002234_abnormal_pharynx_morphology1.76350274
21MP0002102_abnormal_ear_morphology1.74444612
22MP0001697_abnormal_embryo_size1.73069478
23MP0005394_taste/olfaction_phenotype1.70828830
24MP0005499_abnormal_olfactory_system1.70828830
25MP0002396_abnormal_hematopoietic_system1.70261599
26MP0008995_early_reproductive_senescence1.63370488
27MP0006035_abnormal_mitochondrial_morpho1.61310547
28MP0002080_prenatal_lethality1.51510743
29MP0001672_abnormal_embryogenesis/_devel1.50676855
30MP0005380_embryogenesis_phenotype1.50676855
31MP0003718_maternal_effect1.50204041
32MP0004197_abnormal_fetal_growth/weight/1.42234335
33MP0000313_abnormal_cell_death1.39472632
34MP0006036_abnormal_mitochondrial_physio1.38613614
35MP0001293_anophthalmia1.38081985
36MP0004233_abnormal_muscle_weight1.36709732
37MP0003984_embryonic_growth_retardation1.34699870
38MP0000358_abnormal_cell_content/1.32234627
39MP0003315_abnormal_perineum_morphology1.29628325
40MP0000490_abnormal_crypts_of1.29323014
41MP0002085_abnormal_embryonic_tissue1.27703102
42MP0003121_genomic_imprinting1.26303831
43MP0002088_abnormal_embryonic_growth/wei1.25862559
44MP0003385_abnormal_body_wall1.24379018
45MP0008260_abnormal_autophagy1.20862987
46MP0000049_abnormal_middle_ear1.18842672
47MP0002084_abnormal_developmental_patter1.18787466
48MP0002132_abnormal_respiratory_system1.18594474
49MP0003122_maternal_imprinting1.15506790
50MP0003937_abnormal_limbs/digits/tail_de1.14840615
51MP0005501_abnormal_skin_physiology1.13727177
52MP0008961_abnormal_basal_metabolism1.08807220
53MP0002019_abnormal_tumor_incidence1.06054685
54MP0009672_abnormal_birth_weight1.04989791
55MP0004147_increased_porphyrin_level1.04464080
56MP0006292_abnormal_olfactory_placode1.03913414
57MP0001286_abnormal_eye_development1.03590234
58MP0005084_abnormal_gallbladder_morpholo1.00168935
59MP0002086_abnormal_extraembryonic_tissu0.99935148
60MP0000537_abnormal_urethra_morphology0.98183717
61MP0000516_abnormal_urinary_system0.95663508
62MP0005367_renal/urinary_system_phenotyp0.95663508
63MP0003890_abnormal_embryonic-extraembry0.95218239
64MP0003567_abnormal_fetal_cardiomyocyte0.95046586
65MP0003119_abnormal_digestive_system0.88039935
66MP0001661_extended_life_span0.86257471
67MP0003755_abnormal_palate_morphology0.83976672
68MP0005384_cellular_phenotype0.83499785
69MP0006072_abnormal_retinal_apoptosis0.82807560
70MP0001188_hyperpigmentation0.82382239
71MP0002111_abnormal_tail_morphology0.80393966
72MP0000566_synostosis0.78004345
73MP0002697_abnormal_eye_size0.76384029
74MP0002233_abnormal_nose_morphology0.75397042
75MP0001346_abnormal_lacrimal_gland0.74757270
76MP0005266_abnormal_metabolism0.74425573
77MP0002210_abnormal_sex_determination0.73985809
78MP0003861_abnormal_nervous_system0.72849889
79MP0009703_decreased_birth_body0.72264261
80MP0010030_abnormal_orbit_morphology0.72061755
81MP0003115_abnormal_respiratory_system0.71668954
82MP0001929_abnormal_gametogenesis0.71224481
83MP0002269_muscular_atrophy0.69673572
84MP0003935_abnormal_craniofacial_develop0.68891203
85MP0002092_abnormal_eye_morphology0.68813762
86MP0000579_abnormal_nail_morphology0.68052095
87MP0001764_abnormal_homeostasis0.67602539
88MP0002751_abnormal_autonomic_nervous0.66841022
89MP0001984_abnormal_olfaction0.66399389
90MP0000762_abnormal_tongue_morphology0.65921461
91MP0003656_abnormal_erythrocyte_physiolo0.65918128
92MP0004811_abnormal_neuron_physiology0.64923582
93MP0005083_abnormal_biliary_tract0.63228426
94MP0003186_abnormal_redox_activity0.62248849
95MP0002177_abnormal_outer_ear0.61031069
96MP0001145_abnormal_male_reproductive0.60913579
97MP0002081_perinatal_lethality0.60385112
98MP0002282_abnormal_trachea_morphology0.59943410
99MP0005621_abnormal_cell_physiology0.59571517
100MP0005187_abnormal_penis_morphology0.58044688

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.43384961
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85118500
3Abnormality of glycolysis (HP:0004366)3.66916213
4Increased serum pyruvate (HP:0003542)3.55109694
5Chromsome breakage (HP:0040012)3.54190441
6Medulloblastoma (HP:0002885)3.27421272
7Abnormality of the preputium (HP:0100587)3.23155680
8Cortical dysplasia (HP:0002539)3.17316157
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.16739467
10Abnormality of chromosome stability (HP:0003220)3.10680084
11Meckel diverticulum (HP:0002245)3.03727352
12Small intestinal stenosis (HP:0012848)2.97418359
13Duodenal stenosis (HP:0100867)2.97418359
14Ragged-red muscle fibers (HP:0003200)2.93366765
15Cerebral hypomyelination (HP:0006808)2.90636473
16Type I transferrin isoform profile (HP:0003642)2.87774512
17Abnormal protein N-linked glycosylation (HP:0012347)2.86323612
18Abnormal protein glycosylation (HP:0012346)2.86323612
19Abnormal glycosylation (HP:0012345)2.86323612
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.86323612
21Abnormality of the ileum (HP:0001549)2.84456308
22Hepatocellular necrosis (HP:0001404)2.73896544
23Retinal dysplasia (HP:0007973)2.67565832
24Hepatic necrosis (HP:0002605)2.64862462
25Progressive muscle weakness (HP:0003323)2.64077876
26Hypoplastic pelvis (HP:0008839)2.63185894
27Myelodysplasia (HP:0002863)2.57921666
28Increased serum lactate (HP:0002151)2.52478463
29Shoulder girdle muscle weakness (HP:0003547)2.51904115
30Abnormality of the labia minora (HP:0012880)2.49664192
31Multiple enchondromatosis (HP:0005701)2.45766255
32Increased hepatocellular lipid droplets (HP:0006565)2.40084754
33Abnormality of the duodenum (HP:0002246)2.37710798
34Postnatal microcephaly (HP:0005484)2.36699766
35Lipid accumulation in hepatocytes (HP:0006561)2.33004042
36Increased CSF lactate (HP:0002490)2.28734980
37Degeneration of anterior horn cells (HP:0002398)2.26570360
38Abnormality of the anterior horn cell (HP:0006802)2.26570360
39Overlapping toe (HP:0001845)2.15944280
40Pelvic girdle muscle weakness (HP:0003749)2.15917081
41Abnormal mitochondria in muscle tissue (HP:0008316)2.14869192
42Mitochondrial inheritance (HP:0001427)2.14791539
43Acute encephalopathy (HP:0006846)2.13505254
44Reticulocytopenia (HP:0001896)2.13158706
45Proximal placement of thumb (HP:0009623)2.10355420
46Dry hair (HP:0011359)2.02996705
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02751779
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02751779
49Acute necrotizing encephalopathy (HP:0006965)2.01726715
50Absent radius (HP:0003974)2.00850861
51Lactic acidosis (HP:0003128)2.00808598
52Pancytopenia (HP:0001876)2.00748615
53Squamous cell carcinoma (HP:0002860)2.00367571
54Abnormality of the carotid arteries (HP:0005344)1.99918449
55Ependymoma (HP:0002888)1.99653940
56Failure to thrive in infancy (HP:0001531)1.98778775
57Sloping forehead (HP:0000340)1.98631424
58Increased nuchal translucency (HP:0010880)1.97736652
59Abnormal number of erythroid precursors (HP:0012131)1.97506740
60Absent forearm bone (HP:0003953)1.97198812
61Aplasia involving forearm bones (HP:0009822)1.97198812
62Emotional lability (HP:0000712)1.96546949
63Birth length less than 3rd percentile (HP:0003561)1.93976644
64Abnormality of reticulocytes (HP:0004312)1.93534118
65Spastic paraparesis (HP:0002313)1.93502261
66Abnormal lung lobation (HP:0002101)1.93389841
67Horseshoe kidney (HP:0000085)1.91120700
68Cerebral edema (HP:0002181)1.90358243
69Reduced antithrombin III activity (HP:0001976)1.89217099
70Abnormality of the musculature of the pelvis (HP:0001469)1.88828048
71Abnormality of the hip-girdle musculature (HP:0001445)1.88828048
72Decreased lacrimation (HP:0000633)1.88452133
73Exercise intolerance (HP:0003546)1.84943633
74Reticulocytosis (HP:0001923)1.84238260
75Increased intramyocellular lipid droplets (HP:0012240)1.82093881
76Triphalangeal thumb (HP:0001199)1.81772070
77Lissencephaly (HP:0001339)1.79432713
78Brushfield spots (HP:0001088)1.78965921
79Deviation of the thumb (HP:0009603)1.78873426
80Abnormal hair laboratory examination (HP:0003328)1.76727613
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74617065
82Patellar aplasia (HP:0006443)1.74338180
83CNS hypomyelination (HP:0003429)1.74051314
84Premature ovarian failure (HP:0008209)1.72845662
85Progressive inability to walk (HP:0002505)1.71387441
86Short middle phalanx of the 5th finger (HP:0004220)1.70771387
87Opisthotonus (HP:0002179)1.69949673
88Cholecystitis (HP:0001082)1.68749543
89Abnormal gallbladder physiology (HP:0012438)1.68749543
90B lymphocytopenia (HP:0010976)1.68512205
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68299025
92Long nose (HP:0003189)1.67490102
93Hyperglycinemia (HP:0002154)1.66685071
94Poikiloderma (HP:0001029)1.66646915
95Prominent metopic ridge (HP:0005487)1.63692109
96Choanal atresia (HP:0000453)1.62580868
97Bone marrow hypocellularity (HP:0005528)1.62026565
98Nephrogenic diabetes insipidus (HP:0009806)1.61746982
99Abnormality of cells of the erythroid lineage (HP:0012130)1.61087333
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60773490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.55562561
2BUB14.52281901
3TRIM283.08160102
4NEK13.03665564
5CDC72.85384059
6TSSK62.67528053
7BCR2.55197279
8STK162.50290388
9PLK42.44618941
10EIF2AK12.29725141
11TESK22.19819687
12VRK22.18502327
13BRSK22.14002848
14TTK2.10424111
15SIK32.05879262
16RPS6KA42.02057238
17CCNB11.98896563
18EIF2AK31.92116434
19BCKDK1.85694679
20PBK1.74691954
21VRK11.69001954
22MAP2K71.65377743
23PLK31.65155172
24CSNK1A1L1.63443062
25CDK81.55569670
26CSNK1G31.55409515
27ATR1.51522461
28BRSK11.48381125
29PLK11.44405600
30PIM21.40077470
31AURKB1.37488122
32MKNK11.36911036
33STK38L1.35047165
34WEE11.34371719
35CHEK21.33451469
36SCYL21.30250397
37CSNK1G11.28135578
38MAP4K21.27244964
39BRD41.24602154
40MAP3K61.21299526
41CDK121.13202869
42KSR11.11779717
43MAP3K51.05340554
44ZAK1.03046730
45DYRK30.98652994
46CDK70.97023628
47CHEK10.96896311
48CSNK1G20.91708324
49PKN10.88315402
50TESK10.87062605
51AURKA0.86127969
52RAF10.83771508
53CLK10.82886062
54WNK30.82451228
55ATM0.79823746
56DAPK10.79521295
57CDK60.76350453
58MINK10.74960109
59NEK20.74941060
60NME20.73349201
61EIF2AK20.71985390
62DYRK1B0.70482252
63MST1R0.69048687
64PDK20.68248697
65CDK40.67021448
66RPS6KA50.65533811
67MAP3K40.64939473
68LIMK10.61392387
69CDK20.60512525
70CDK140.58429970
71CDK180.56613440
72STK240.55259712
73NUAK10.53434336
74CDK90.51361782
75CDK10.51002735
76MAP2K40.50173273
77PASK0.49440795
78BMPR1B0.49305492
79PLK20.47937785
80MAP3K100.47917354
81TAF10.47375596
82CSNK2A10.46774513
83ERBB30.46584239
84CSNK2A20.45865337
85MKNK20.45210242
86CDK150.44645039
87MST40.42487984
88PAK40.40244712
89FLT30.39622866
90NME10.39216186
91CDK11A0.38771514
92MAP3K80.37191346
93STK40.31741892
94INSRR0.31633951
95MAP3K120.31257079
96CSNK1E0.30650990
97AKT20.29545986
98EPHA40.29106648
99ERBB40.28447717
100LMTK20.27752422

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.33777527
2Mismatch repair_Homo sapiens_hsa034303.58954925
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34152937
4Proteasome_Homo sapiens_hsa030503.17746913
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.17173883
6Base excision repair_Homo sapiens_hsa034103.16739797
7Spliceosome_Homo sapiens_hsa030403.14060402
8Non-homologous end-joining_Homo sapiens_hsa034502.60762908
9RNA transport_Homo sapiens_hsa030132.51098311
10Fanconi anemia pathway_Homo sapiens_hsa034602.49161779
11RNA polymerase_Homo sapiens_hsa030202.45251002
12Cell cycle_Homo sapiens_hsa041102.39309972
13Nucleotide excision repair_Homo sapiens_hsa034202.37163094
14Homologous recombination_Homo sapiens_hsa034402.36974729
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19392509
16Pyrimidine metabolism_Homo sapiens_hsa002402.19169445
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88014612
18mRNA surveillance pathway_Homo sapiens_hsa030151.86196821
19One carbon pool by folate_Homo sapiens_hsa006701.66116602
20Biosynthesis of amino acids_Homo sapiens_hsa012301.62460431
21Steroid biosynthesis_Homo sapiens_hsa001001.57764761
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57540263
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57509040
24RNA degradation_Homo sapiens_hsa030181.51260907
25Protein export_Homo sapiens_hsa030601.47277550
26Pyruvate metabolism_Homo sapiens_hsa006201.43608400
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.42811652
28Basal transcription factors_Homo sapiens_hsa030221.42184263
29Propanoate metabolism_Homo sapiens_hsa006401.41604149
30Folate biosynthesis_Homo sapiens_hsa007901.41387107
31Carbon metabolism_Homo sapiens_hsa012001.38576178
32Fatty acid elongation_Homo sapiens_hsa000621.28817023
33Purine metabolism_Homo sapiens_hsa002301.28271070
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27951684
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26725061
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26694509
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25972701
38Parkinsons disease_Homo sapiens_hsa050121.21417290
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20349077
40Sulfur relay system_Homo sapiens_hsa041221.19505629
41Huntingtons disease_Homo sapiens_hsa050161.14583824
42Oxidative phosphorylation_Homo sapiens_hsa001901.13168128
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12654540
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08471484
45Oocyte meiosis_Homo sapiens_hsa041141.06626823
46Ribosome_Homo sapiens_hsa030101.06387389
47p53 signaling pathway_Homo sapiens_hsa041151.04518761
48Alcoholism_Homo sapiens_hsa050340.98968440
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96771389
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96302989
51Systemic lupus erythematosus_Homo sapiens_hsa053220.93731580
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92400579
53Butanoate metabolism_Homo sapiens_hsa006500.91263312
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86034163
55N-Glycan biosynthesis_Homo sapiens_hsa005100.72784629
56Epstein-Barr virus infection_Homo sapiens_hsa051690.67774373
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65780031
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63317597
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61661645
60Viral carcinogenesis_Homo sapiens_hsa052030.61207901
61Pentose phosphate pathway_Homo sapiens_hsa000300.60563232
62Lysine degradation_Homo sapiens_hsa003100.56333698
63Fatty acid metabolism_Homo sapiens_hsa012120.55975873
64Metabolic pathways_Homo sapiens_hsa011000.54412002
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54340428
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53056088
67Shigellosis_Homo sapiens_hsa051310.50849922
68Alzheimers disease_Homo sapiens_hsa050100.50331335
69Selenocompound metabolism_Homo sapiens_hsa004500.48981890
70TGF-beta signaling pathway_Homo sapiens_hsa043500.45354477
71Nicotine addiction_Homo sapiens_hsa050330.40883593
72Colorectal cancer_Homo sapiens_hsa052100.38533187
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.38102567
74Glutathione metabolism_Homo sapiens_hsa004800.37039154
75Vibrio cholerae infection_Homo sapiens_hsa051100.33628593
76Peroxisome_Homo sapiens_hsa041460.31430143
77Bladder cancer_Homo sapiens_hsa052190.28666719
78Legionellosis_Homo sapiens_hsa051340.28563218
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.25749720
80Arginine and proline metabolism_Homo sapiens_hsa003300.25512317
81MicroRNAs in cancer_Homo sapiens_hsa052060.25465264
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25320680
83Fructose and mannose metabolism_Homo sapiens_hsa000510.24391269
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24121872
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24054022
86Herpes simplex infection_Homo sapiens_hsa051680.22292168
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21976236
88Thyroid cancer_Homo sapiens_hsa052160.21641501
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14631917
90Hippo signaling pathway_Homo sapiens_hsa043900.14456917
91Galactose metabolism_Homo sapiens_hsa000520.14215748
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13961146
93Apoptosis_Homo sapiens_hsa042100.13816451
94beta-Alanine metabolism_Homo sapiens_hsa004100.13306613
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13077082
96Salmonella infection_Homo sapiens_hsa051320.10050650
97Arginine biosynthesis_Homo sapiens_hsa002200.08136349
98Hepatitis B_Homo sapiens_hsa051610.07358491
99AMPK signaling pathway_Homo sapiens_hsa041520.07126882
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04826483

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