MCPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.91310406
2nuclear pore complex assembly (GO:0051292)4.79644361
3nuclear pore organization (GO:0006999)4.75352106
4regulation of helicase activity (GO:0051095)4.60150462
5protein localization to kinetochore (GO:0034501)4.53284518
6kinetochore organization (GO:0051383)4.47575487
7metaphase plate congression (GO:0051310)4.42993421
8L-fucose catabolic process (GO:0042355)4.31482926
9fucose catabolic process (GO:0019317)4.31482926
10L-fucose metabolic process (GO:0042354)4.31482926
11mitotic sister chromatid segregation (GO:0000070)4.27004687
12meiotic chromosome segregation (GO:0045132)4.24499068
13protein K11-linked deubiquitination (GO:0035871)4.21123696
14CENP-A containing nucleosome assembly (GO:0034080)4.20998991
15mitotic nuclear envelope disassembly (GO:0007077)4.18715766
16chromatin remodeling at centromere (GO:0031055)4.16348098
17protein localization to chromosome, centromeric region (GO:0071459)4.08906648
18mitotic chromosome condensation (GO:0007076)4.08322098
19mitotic sister chromatid cohesion (GO:0007064)4.07619748
20DNA replication checkpoint (GO:0000076)4.05306153
21DNA replication initiation (GO:0006270)4.04633469
22regulation of spindle organization (GO:0090224)4.01735860
23kinetochore assembly (GO:0051382)4.01637443
24DNA double-strand break processing (GO:0000729)3.97286166
25establishment of chromosome localization (GO:0051303)3.91510891
26nuclear envelope disassembly (GO:0051081)3.91160253
27membrane disassembly (GO:0030397)3.91160253
28sister chromatid segregation (GO:0000819)3.91032027
29pore complex assembly (GO:0046931)3.87499545
30DNA replication-independent nucleosome organization (GO:0034724)3.87057822
31DNA replication-independent nucleosome assembly (GO:0006336)3.87057822
32neural tube formation (GO:0001841)3.79521461
33DNA replication-dependent nucleosome assembly (GO:0006335)3.78770600
34DNA replication-dependent nucleosome organization (GO:0034723)3.78770600
35attachment of spindle microtubules to kinetochore (GO:0008608)3.78547981
36behavioral response to nicotine (GO:0035095)3.77882335
37DNA unwinding involved in DNA replication (GO:0006268)3.77425005
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74699371
39regulation of mitotic spindle organization (GO:0060236)3.72585643
40DNA strand elongation involved in DNA replication (GO:0006271)3.69208097
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.68987523
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67731347
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.65621095
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.63704827
45spindle checkpoint (GO:0031577)3.61909889
46histone exchange (GO:0043486)3.57311845
47ribosome assembly (GO:0042255)3.55512814
48DNA strand elongation (GO:0022616)3.54282202
49IMP biosynthetic process (GO:0006188)3.50745821
50telomere maintenance via semi-conservative replication (GO:0032201)3.49490297
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.48405765
52protein K6-linked ubiquitination (GO:0085020)3.47892054
53regulation of centrosome cycle (GO:0046605)3.47068154
54telomere maintenance via recombination (GO:0000722)3.46086779
55rRNA catabolic process (GO:0016075)3.45677653
56nonmotile primary cilium assembly (GO:0035058)3.41941959
57positive regulation of chromosome segregation (GO:0051984)3.41904632
58regulation of chromosome segregation (GO:0051983)3.40845099
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.40365559
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40365559
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40365559
62spindle assembly checkpoint (GO:0071173)3.40192552
63negative regulation of chromosome segregation (GO:0051985)3.40040614
64protein localization to chromosome (GO:0034502)3.39691190
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39578642
66nucleobase biosynthetic process (GO:0046112)3.39003992
67centriole replication (GO:0007099)3.38662928
68mismatch repair (GO:0006298)3.37991057
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37564296
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36097323
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.36053073
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36053073
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36053073
74negative regulation of sister chromatid segregation (GO:0033046)3.36053073
75chromosome segregation (GO:0007059)3.35659952
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.34804744
77mitotic recombination (GO:0006312)3.34680962
78replication fork processing (GO:0031297)3.33714989
79mitotic spindle assembly checkpoint (GO:0007094)3.33360518
80regulation of sister chromatid cohesion (GO:0007063)3.32805437
81chromatin assembly or disassembly (GO:0006333)3.32153550
82mitotic spindle checkpoint (GO:0071174)3.32090524
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31651530
84purine nucleobase biosynthetic process (GO:0009113)3.30990409
85establishment of protein localization to Golgi (GO:0072600)3.30804269
86maturation of SSU-rRNA (GO:0030490)3.30772619
87axoneme assembly (GO:0035082)3.30607517
88intra-S DNA damage checkpoint (GO:0031573)3.28887341
89regulation of histone H3-K9 methylation (GO:0051570)3.26681846
90double-strand break repair via homologous recombination (GO:0000724)3.26185332
91telomere maintenance via telomere lengthening (GO:0010833)3.25898951
92regulation of sister chromatid segregation (GO:0033045)3.25659023
93regulation of mitotic sister chromatid separation (GO:0010965)3.25659023
94regulation of mitotic sister chromatid segregation (GO:0033047)3.25659023
95recombinational repair (GO:0000725)3.24967375
96respiratory chain complex IV assembly (GO:0008535)3.23670704
97negative regulation of histone methylation (GO:0031061)3.22966314
98DNA geometric change (GO:0032392)3.21566081
99detection of light stimulus involved in visual perception (GO:0050908)3.20754573
100detection of light stimulus involved in sensory perception (GO:0050962)3.20754573
101cilium or flagellum-dependent cell motility (GO:0001539)3.19480113
102pre-miRNA processing (GO:0031054)3.17876720
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.16869499
104DNA duplex unwinding (GO:0032508)3.14723931
105IMP metabolic process (GO:0046040)3.13808795
106negative regulation of DNA recombination (GO:0045910)3.12715112
107DNA deamination (GO:0045006)3.12111408
108monoubiquitinated protein deubiquitination (GO:0035520)3.11870569
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10778698
110regulation of mitotic spindle checkpoint (GO:1903504)3.09585699
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09585699
112inner cell mass cell proliferation (GO:0001833)3.09562171
113indolalkylamine metabolic process (GO:0006586)3.09107865
114DNA synthesis involved in DNA repair (GO:0000731)3.08832943
115microtubule depolymerization (GO:0007019)3.07944164
116epithelial cilium movement (GO:0003351)3.06919336
117histone mRNA catabolic process (GO:0071044)3.05840674
118indolalkylamine catabolic process (GO:0046218)3.05508168
119tryptophan catabolic process (GO:0006569)3.05508168
120indole-containing compound catabolic process (GO:0042436)3.05508168
121response to pheromone (GO:0019236)3.04311863
122somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03182722
123somatic hypermutation of immunoglobulin genes (GO:0016446)3.03182722
124signal peptide processing (GO:0006465)3.02302408
125regulation of DNA-dependent DNA replication (GO:0090329)3.00236503
126regulation of centriole replication (GO:0046599)2.99377298
127telomere maintenance (GO:0000723)2.98729865
128mitotic G2/M transition checkpoint (GO:0044818)2.96753707
129nuclear envelope organization (GO:0006998)2.96723814
130telomere organization (GO:0032200)2.96314242
131ribosome biogenesis (GO:0042254)2.96198860
132retinal cone cell development (GO:0046549)2.95883114
133photoreceptor cell maintenance (GO:0045494)2.94740774
134reciprocal meiotic recombination (GO:0007131)2.94559486
135reciprocal DNA recombination (GO:0035825)2.94559486
136kynurenine metabolic process (GO:0070189)2.83959167
137interkinetic nuclear migration (GO:0022027)2.82546196
138cilium morphogenesis (GO:0060271)2.82116365
139protein targeting to Golgi (GO:0000042)2.81482225
140piRNA metabolic process (GO:0034587)2.80566928
141centriole assembly (GO:0098534)2.79670161
142platelet dense granule organization (GO:0060155)2.78185312
143snRNA transcription (GO:0009301)2.75767828
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73198010
145regulation of telomere maintenance (GO:0032204)2.73066521
146histone H3-K9 methylation (GO:0051567)2.72944264
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72770703
148negative regulation of mast cell activation (GO:0033004)2.72343722
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.71976389
150NADH dehydrogenase complex assembly (GO:0010257)2.71976389
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71976389
152protein polyglutamylation (GO:0018095)2.69227019
153prenylation (GO:0097354)2.68546132
154protein prenylation (GO:0018342)2.68546132
155cilium movement (GO:0003341)2.64355214
156cilium organization (GO:0044782)2.63465277
157ncRNA catabolic process (GO:0034661)2.63001908
158tryptophan metabolic process (GO:0006568)2.62527761
159water-soluble vitamin biosynthetic process (GO:0042364)2.62214008
160ubiquinone metabolic process (GO:0006743)2.62138729
161microtubule anchoring (GO:0034453)2.61814665
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61699916
163cellular ketone body metabolic process (GO:0046950)2.59965313
164pyrimidine dimer repair (GO:0006290)2.59759893
165regulation of glucokinase activity (GO:0033131)2.57725087
166regulation of hexokinase activity (GO:1903299)2.57725087
167cilium assembly (GO:0042384)2.57344333
168replicative senescence (GO:0090399)2.55342560
169cytochrome complex assembly (GO:0017004)2.54651920
170pseudouridine synthesis (GO:0001522)2.54643773
171histone mRNA metabolic process (GO:0008334)2.53205261
172DNA methylation involved in gamete generation (GO:0043046)2.53121071
173regulation of DNA endoreduplication (GO:0032875)2.51298673
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.51212306
175regulation of translation, ncRNA-mediated (GO:0045974)2.51212306
176negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51212306
177regulation of meiosis I (GO:0060631)2.50524974
178ubiquinone biosynthetic process (GO:0006744)2.50364766
179auditory receptor cell stereocilium organization (GO:0060088)2.48783138
180regulation of cilium movement (GO:0003352)2.47849192
181L-methionine salvage (GO:0071267)2.46030571
182L-methionine biosynthetic process (GO:0071265)2.46030571
183amino acid salvage (GO:0043102)2.46030571
184gene silencing by RNA (GO:0031047)2.45928540
185intraciliary transport (GO:0042073)2.44994743
186protein complex biogenesis (GO:0070271)2.44360412
187retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44095068
188postreplication repair (GO:0006301)2.43414435
189interferon-gamma production (GO:0032609)2.42935269
190anterograde synaptic vesicle transport (GO:0048490)2.42929215
191positive regulation of oligodendrocyte differentiation (GO:0048714)2.42494090
192maturation of 5.8S rRNA (GO:0000460)2.42440980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.70648326
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.53857575
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90722327
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.79274814
5IGF1R_20145208_ChIP-Seq_DFB_Human3.21837824
6ZNF274_21170338_ChIP-Seq_K562_Hela3.15741298
7VDR_22108803_ChIP-Seq_LS180_Human2.98489461
8GBX2_23144817_ChIP-Seq_PC3_Human2.96068071
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82798930
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67474982
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60030902
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58104163
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.53260198
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.52357221
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52320807
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.49684058
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47241643
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44666907
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.37370582
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37108808
21AR_21909140_ChIP-Seq_LNCAP_Human2.36119314
22FUS_26573619_Chip-Seq_HEK293_Human2.35357246
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29783759
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28446559
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25282065
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23430591
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21140432
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.13420206
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12318469
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10924181
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05823531
32VDR_23849224_ChIP-Seq_CD4+_Human2.02863759
33TP63_19390658_ChIP-ChIP_HaCaT_Human2.02714538
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.02253759
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00697251
36TAF15_26573619_Chip-Seq_HEK293_Human2.00679644
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00594821
38E2F7_22180533_ChIP-Seq_HELA_Human10.7727496
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.98944146
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98853950
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95991548
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95596770
43ER_23166858_ChIP-Seq_MCF-7_Human1.91233441
44P300_19829295_ChIP-Seq_ESCs_Human1.90755727
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88219757
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84635137
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83202488
48XRN2_22483619_ChIP-Seq_HELA_Human1.81975096
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79381357
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77968162
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76069787
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72458636
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72414800
54* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70720698
55ELK1_19687146_ChIP-ChIP_HELA_Human1.69454617
56EZH2_22144423_ChIP-Seq_EOC_Human1.69448846
57FOXP3_21729870_ChIP-Seq_TREG_Human1.68109440
58CBP_20019798_ChIP-Seq_JUKART_Human1.66498110
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66498110
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66167307
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64773912
62* STAT3_23295773_ChIP-Seq_U87_Human1.63518019
63TTF2_22483619_ChIP-Seq_HELA_Human1.56828984
64* GABP_19822575_ChIP-Seq_HepG2_Human1.52926353
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51494560
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51385535
67* TCF4_23295773_ChIP-Seq_U87_Human1.50765501
68SMAD4_21799915_ChIP-Seq_A2780_Human1.50678916
69* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49732628
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49279705
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48630990
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48096336
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47814556
74BCAT_22108803_ChIP-Seq_LS180_Human1.47094522
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45881146
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.45396884
77DCP1A_22483619_ChIP-Seq_HELA_Human1.45313006
78MYC_22102868_ChIP-Seq_BL_Human1.45040378
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43728589
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42597229
81CIITA_25753668_ChIP-Seq_RAJI_Human1.42509674
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41427545
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40904813
84KDM5A_27292631_Chip-Seq_BREAST_Human1.39059744
85IRF1_19129219_ChIP-ChIP_H3396_Human1.36411460
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36342823
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34925514
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.34576119
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34388243
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33940838
91* TP53_22573176_ChIP-Seq_HFKS_Human1.32774530
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30584435
93* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30052589
94TCF4_22108803_ChIP-Seq_LS180_Human1.28630338
95* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28405551
96* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28405551
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25088927
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25047236
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24621684
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.22894569
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22479646
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21766565
103* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21731394
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21691506
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21591514
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20547077
107* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20346695
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.19458025
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19011727
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.17799935
111AR_25329375_ChIP-Seq_VCAP_Human1.17188537
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.17158892
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.16218861
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16158372
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15460145
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14751320
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13917917
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13732446
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13277350
120AR_21572438_ChIP-Seq_LNCaP_Human1.12777549
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.12332541
122SOX2_19829295_ChIP-Seq_ESCs_Human1.12047377
123NANOG_19829295_ChIP-Seq_ESCs_Human1.12047377
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.11561061
125P53_22387025_ChIP-Seq_ESCs_Mouse1.10437408
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10049091
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09603681
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09350565
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.09088914
130RUNX2_22187159_ChIP-Seq_PCA_Human1.07725004
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07688043
132* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07350363
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07314979
134* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06953861
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06553464
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.05678923
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.05331505
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04237037
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03529651
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02099933
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01477523
142MYC_18940864_ChIP-ChIP_HL60_Human1.01072682
143STAT3_18555785_Chip-Seq_ESCs_Mouse1.00763981
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00712096
145TP53_16413492_ChIP-PET_HCT116_Human1.00692245
146SMAD4_21741376_ChIP-Seq_EPCs_Human1.00311939
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00292373
148RNF2_27304074_Chip-Seq_NSC_Mouse0.99628915
149TFEB_21752829_ChIP-Seq_HELA_Human0.97761056
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97358713
151CDX2_22108803_ChIP-Seq_LS180_Human0.97239748
152P300_18555785_Chip-Seq_ESCs_Mouse0.97237482
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97082602
154* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95585115
155* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94504798
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92574036
157* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92566585
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91634174
159HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89717967
160NANOG_21062744_ChIP-ChIP_HESCs_Human0.88740622
161SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88243720
162* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88011420
163* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87934271
164TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85223011
165CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85211445
166CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85011944
167SPI1_23547873_ChIP-Seq_NB4_Human0.82038358
168* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81988643
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81052463
170NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80728848
171NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76414213
172TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75928233
173SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74932455
174NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74422341
175* EWS_26573619_Chip-Seq_HEK293_Human0.67702196
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66180159
177KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66180159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.64614969
2* MP0003111_abnormal_nucleus_morphology4.77797419
3* MP0010094_abnormal_chromosome_stability4.59575338
4* MP0003077_abnormal_cell_cycle3.98807678
5MP0004957_abnormal_blastocyst_morpholog3.89830957
6MP0008057_abnormal_DNA_replication3.58536667
7MP0008058_abnormal_DNA_repair3.47090897
8MP0002396_abnormal_hematopoietic_system2.79487086
9MP0008007_abnormal_cellular_replicative2.72032171
10MP0000427_abnormal_hair_cycle2.67780122
11MP0008877_abnormal_DNA_methylation2.43594510
12MP0010307_abnormal_tumor_latency2.40722822
13MP0003646_muscle_fatigue2.38280787
14MP0008932_abnormal_embryonic_tissue2.31254203
15MP0002736_abnormal_nociception_after2.27903050
16MP0001968_abnormal_touch/_nociception2.15747830
17MP0001730_embryonic_growth_arrest2.13504244
18MP0003123_paternal_imprinting2.12908403
19MP0009046_muscle_twitch2.12024231
20MP0000350_abnormal_cell_proliferation2.11821622
21MP0005551_abnormal_eye_electrophysiolog2.09782868
22MP0003718_maternal_effect2.07792017
23MP0009697_abnormal_copulation2.04612308
24MP0010352_gastrointestinal_tract_polyps1.94515178
25MP0003121_genomic_imprinting1.86334463
26MP0005380_embryogenesis_phenotype1.84446067
27MP0001672_abnormal_embryogenesis/_devel1.84446067
28MP0005645_abnormal_hypothalamus_physiol1.84108687
29MP0003195_calcinosis1.83413444
30MP0006276_abnormal_autonomic_nervous1.74075121
31MP0003786_premature_aging1.73480150
32MP0000490_abnormal_crypts_of1.72780252
33MP0001986_abnormal_taste_sensitivity1.71332037
34MP0005253_abnormal_eye_physiology1.70576588
35MP0004808_abnormal_hematopoietic_stem1.69340143
36MP0000383_abnormal_hair_follicle1.65072256
37MP0000569_abnormal_digit_pigmentation1.63133092
38MP0004043_abnormal_pH_regulation1.61219161
39MP0006072_abnormal_retinal_apoptosis1.59277337
40MP0003984_embryonic_growth_retardation1.58855980
41MP0006292_abnormal_olfactory_placode1.58769908
42MP0002085_abnormal_embryonic_tissue1.56185384
43MP0002088_abnormal_embryonic_growth/wei1.55340083
44MP0001697_abnormal_embryo_size1.54839846
45MP0002084_abnormal_developmental_patter1.52129291
46MP0003880_abnormal_central_pattern1.51670550
47MP0005076_abnormal_cell_differentiation1.47563692
48MP0004145_abnormal_muscle_electrophysio1.47208871
49MP0001984_abnormal_olfaction1.47106797
50MP0002086_abnormal_extraembryonic_tissu1.46165280
51MP0005646_abnormal_pituitary_gland1.44835970
52MP0003941_abnormal_skin_development1.42776038
53MP0000372_irregular_coat_pigmentation1.42151876
54MP0002080_prenatal_lethality1.41951338
55MP0008872_abnormal_physiological_respon1.41264060
56* MP0000313_abnormal_cell_death1.39620830
57MP0004147_increased_porphyrin_level1.39503731
58* MP0002210_abnormal_sex_determination1.39480771
59MP0002019_abnormal_tumor_incidence1.33915744
60MP0009745_abnormal_behavioral_response1.32360456
61MP0004142_abnormal_muscle_tone1.32091581
62MP0000631_abnormal_neuroendocrine_gland1.30878034
63MP0002102_abnormal_ear_morphology1.28956351
64MP0003315_abnormal_perineum_morphology1.28214575
65MP0008789_abnormal_olfactory_epithelium1.28187408
66MP0003787_abnormal_imprinting1.25890596
67MP0002735_abnormal_chemical_nociception1.24347248
68MP0002638_abnormal_pupillary_reflex1.23872451
69* MP0001119_abnormal_female_reproductive1.21854592
70MP0003890_abnormal_embryonic-extraembry1.21388044
71MP0001501_abnormal_sleep_pattern1.17830457
72MP0002837_dystrophic_cardiac_calcinosis1.17557314
73MP0001293_anophthalmia1.15708545
74MP0001545_abnormal_hematopoietic_system1.15544936
75MP0005397_hematopoietic_system_phenotyp1.15544936
76MP0004197_abnormal_fetal_growth/weight/1.15486925
77* MP0001929_abnormal_gametogenesis1.12908637
78* MP0001145_abnormal_male_reproductive1.12431325
79MP0004742_abnormal_vestibular_system1.11109728
80* MP0000653_abnormal_sex_gland1.10822101
81MP0000015_abnormal_ear_pigmentation1.08013202
82MP0003567_abnormal_fetal_cardiomyocyte1.07078763
83MP0008961_abnormal_basal_metabolism1.06684187
84MP0003763_abnormal_thymus_physiology1.05974449
85MP0002067_abnormal_sensory_capabilities1.05679414
86MP0002272_abnormal_nervous_system1.05164711
87MP0000566_synostosis1.05158624
88MP0003937_abnormal_limbs/digits/tail_de1.04840496
89MP0010030_abnormal_orbit_morphology1.04820244
90MP0005174_abnormal_tail_pigmentation1.04445497
91MP0008995_early_reproductive_senescence1.03584081
92MP0000647_abnormal_sebaceous_gland1.00139630
93MP0005266_abnormal_metabolism0.99876017
94MP0001486_abnormal_startle_reflex0.99175523
95MP0004215_abnormal_myocardial_fiber0.99048392
96MP0009333_abnormal_splenocyte_physiolog0.98081153
97MP0005187_abnormal_penis_morphology0.97971231
98MP0002751_abnormal_autonomic_nervous0.97459000
99MP0000703_abnormal_thymus_morphology0.97331748
100MP0005386_behavior/neurological_phenoty0.97179464
101MP0004924_abnormal_behavior0.97179464
102MP0005075_abnormal_melanosome_morpholog0.95907987
103MP0004264_abnormal_extraembryonic_tissu0.94242115
104MP0010678_abnormal_skin_adnexa0.93179920
105MP0002398_abnormal_bone_marrow0.93058984
106MP0005394_taste/olfaction_phenotype0.92541728
107MP0005499_abnormal_olfactory_system0.92541728
108* MP0003698_abnormal_male_reproductive0.91001142
109MP0005389_reproductive_system_phenotype0.89798297
110MP0002822_catalepsy0.87093928
111MP0002095_abnormal_skin_pigmentation0.86691690
112MP0005410_abnormal_fertilization0.85999917
113MP0002163_abnormal_gland_morphology0.85936393
114MP0002876_abnormal_thyroid_physiology0.84492730
115MP0002572_abnormal_emotion/affect_behav0.83693896
116MP0005621_abnormal_cell_physiology0.83024902
117MP0002557_abnormal_social/conspecific_i0.80795419
118MP0005384_cellular_phenotype0.80774631
119MP0002160_abnormal_reproductive_system0.80390888
120MP0002877_abnormal_melanocyte_morpholog0.80115127
121MP0002722_abnormal_immune_system0.79145490
122MP0002928_abnormal_bile_duct0.78940462
123MP0001529_abnormal_vocalization0.77776332
124* MP0003699_abnormal_female_reproductive0.76789034
125MP0005195_abnormal_posterior_eye0.76142009
126MP0000689_abnormal_spleen_morphology0.75495597
127MP0005670_abnormal_white_adipose0.75127882
128MP0009672_abnormal_birth_weight0.74694877
129MP0002075_abnormal_coat/hair_pigmentati0.73963311
130MP0008775_abnormal_heart_ventricle0.73848946
131MP0002733_abnormal_thermal_nociception0.73640459
132MP0005671_abnormal_response_to0.73176516
133MP0005379_endocrine/exocrine_gland_phen0.71518236
134MP0003045_fibrosis0.70295615
135MP0000432_abnormal_head_morphology0.70221956
136MP0002752_abnormal_somatic_nervous0.69846520
137MP0001970_abnormal_pain_threshold0.69620039
138MP0002229_neurodegeneration0.69063178
139MP0001324_abnormal_eye_pigmentation0.68612083
140MP0000858_altered_metastatic_potential0.68520120
141MP0001915_intracranial_hemorrhage0.68159501
142MP0001919_abnormal_reproductive_system0.67577589
143MP0002064_seizures0.66986805
144MP0002734_abnormal_mechanical_nocicepti0.66720543
145MP0003943_abnormal_hepatobiliary_system0.66531502
146MP0002009_preneoplasia0.66430744
147MP0002132_abnormal_respiratory_system0.64506933
148MP0002006_tumorigenesis0.64152291
149MP0000371_diluted_coat_color0.64074572
150MP0001186_pigmentation_phenotype0.63651907
151MP0000516_abnormal_urinary_system0.63416207
152MP0005367_renal/urinary_system_phenotyp0.63416207
153MP0001286_abnormal_eye_development0.63369345
154MP0001188_hyperpigmentation0.62747357
155MP0002429_abnormal_blood_cell0.62536362
156MP0005395_other_phenotype0.62446757
157MP0009278_abnormal_bone_marrow0.61853811
158MP0009703_decreased_birth_body0.60000413
159MP0002111_abnormal_tail_morphology0.59582742
160MP0002938_white_spotting0.59269617
161MP0002925_abnormal_cardiovascular_devel0.57751937
162MP0003935_abnormal_craniofacial_develop0.56136108
163MP0002653_abnormal_ependyma_morphology0.56049765
164MP0004133_heterotaxia0.54949985
165MP0003566_abnormal_cell_adhesion0.54653670
166MP0003448_altered_tumor_morphology0.53909904

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.89273070
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.72432897
3Abnormality of chromosome stability (HP:0003220)4.26866999
4Birth length less than 3rd percentile (HP:0003561)4.17960921
5Abnormality of the preputium (HP:0100587)3.97911936
6Pancreatic cysts (HP:0001737)3.90938817
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.82482169
8Meckel diverticulum (HP:0002245)3.76845598
9Abnormality of the ileum (HP:0001549)3.56703668
10Ectopic kidney (HP:0000086)3.52349188
11Pancreatic fibrosis (HP:0100732)3.43196775
12Molar tooth sign on MRI (HP:0002419)3.39320711
13Abnormality of midbrain morphology (HP:0002418)3.39320711
14Type II lissencephaly (HP:0007260)3.32546149
15Medulloblastoma (HP:0002885)3.32326409
16Abnormality of the renal cortex (HP:0011035)3.27593262
17Impulsivity (HP:0100710)3.25526803
18True hermaphroditism (HP:0010459)3.22560210
19Medial flaring of the eyebrow (HP:0010747)3.21697482
20Myelodysplasia (HP:0002863)3.21151816
21Duodenal stenosis (HP:0100867)3.17091385
22Small intestinal stenosis (HP:0012848)3.17091385
23Hyperventilation (HP:0002883)3.16168530
24Reticulocytopenia (HP:0001896)3.14591037
25Chronic hepatic failure (HP:0100626)3.09251058
26Congenital stationary night blindness (HP:0007642)3.06931927
27Breast hypoplasia (HP:0003187)3.06576137
28Colon cancer (HP:0003003)3.06179566
29Patellar aplasia (HP:0006443)3.05741296
30Supernumerary spleens (HP:0009799)2.92135842
31Volvulus (HP:0002580)2.90731065
32Agnosia (HP:0010524)2.85790226
33Ependymoma (HP:0002888)2.83621763
34Aplasia/Hypoplasia of the patella (HP:0006498)2.82848282
35Renal cortical cysts (HP:0000803)2.81856153
36Abnormality of the labia minora (HP:0012880)2.81825942
37Nephronophthisis (HP:0000090)2.80564029
38Clubbing of toes (HP:0100760)2.80297039
39Absent radius (HP:0003974)2.79150972
40Abnormality of the carotid arteries (HP:0005344)2.77673079
41Bone marrow hypocellularity (HP:0005528)2.71814565
42Rhabdomyosarcoma (HP:0002859)2.71618121
43Absent thumb (HP:0009777)2.69582154
44Prostate neoplasm (HP:0100787)2.68480928
45Abnormality of the fingertips (HP:0001211)2.68200747
46Gaze-evoked nystagmus (HP:0000640)2.66031513
47* Sloping forehead (HP:0000340)2.65268035
48Abnormality of the renal medulla (HP:0100957)2.63011302
49Fair hair (HP:0002286)2.61760094
50Abnormality of the duodenum (HP:0002246)2.61632285
51Abnormality of DNA repair (HP:0003254)2.61579451
52Aplasia involving forearm bones (HP:0009822)2.58291351
53Absent forearm bone (HP:0003953)2.58291351
54Duplicated collecting system (HP:0000081)2.55763454
55Oral leukoplakia (HP:0002745)2.54334072
56Congenital primary aphakia (HP:0007707)2.54213769
57Gait imbalance (HP:0002141)2.53680516
58Selective tooth agenesis (HP:0001592)2.53401628
59Protruding tongue (HP:0010808)2.51946629
60Acute myeloid leukemia (HP:0004808)2.49060987
61Abnormality of the renal collecting system (HP:0004742)2.42742341
62Aplastic anemia (HP:0001915)2.41576232
63Prominent nose (HP:0000448)2.38565917
64Hypoplasia of the pons (HP:0012110)2.38484986
65Lissencephaly (HP:0001339)2.36180640
66Nephrogenic diabetes insipidus (HP:0009806)2.34673824
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.34628392
68Genetic anticipation (HP:0003743)2.34584182
69Abolished electroretinogram (ERG) (HP:0000550)2.33773072
70Tracheoesophageal fistula (HP:0002575)2.28878856
71Premature graying of hair (HP:0002216)2.27816167
72Abnormality of the pons (HP:0007361)2.26619417
73Progressive cerebellar ataxia (HP:0002073)2.26204822
74Triphalangeal thumb (HP:0001199)2.25028323
75Cafe-au-lait spot (HP:0000957)2.24254771
76Tubulointerstitial nephritis (HP:0001970)2.20185241
77Cerebellar dysplasia (HP:0007033)2.20135898
78Neoplasm of the oral cavity (HP:0100649)2.18963496
79Inability to walk (HP:0002540)2.15525809
80Neoplasm of the pancreas (HP:0002894)2.14040714
81Short thumb (HP:0009778)2.13823146
82Horseshoe kidney (HP:0000085)2.13534201
83Rough bone trabeculation (HP:0100670)2.12982256
84Acute lymphatic leukemia (HP:0006721)2.12099137
85Abnormality of the anterior horn cell (HP:0006802)2.11958902
86Degeneration of anterior horn cells (HP:0002398)2.11958902
87Attenuation of retinal blood vessels (HP:0007843)2.10854285
88Glioma (HP:0009733)2.10319946
89Hyperglycinemia (HP:0002154)2.09874740
90Cystic liver disease (HP:0006706)2.09101433
91Retinal dysplasia (HP:0007973)2.07323631
92Broad-based gait (HP:0002136)2.05869566
93Carpal bone hypoplasia (HP:0001498)2.05827532
94Increased nuchal translucency (HP:0010880)2.05034195
95Genital tract atresia (HP:0001827)2.04850670
96Poor coordination (HP:0002370)2.03087235
97Syringomyelia (HP:0003396)2.01999769
98Spinal cord lesions (HP:0100561)2.01999769
99Abnormal number of incisors (HP:0011064)2.01920420
100IgG deficiency (HP:0004315)2.01914803
101Oligodactyly (hands) (HP:0001180)2.01615511
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.01050988
103Absent/shortened dynein arms (HP:0200106)2.01050988
104Amaurosis fugax (HP:0100576)1.99696483
105Astrocytoma (HP:0009592)1.99185469
106Abnormality of the astrocytes (HP:0100707)1.99185469
107Drooling (HP:0002307)1.98831212
108Progressive inability to walk (HP:0002505)1.98648242
109Abnormal lung lobation (HP:0002101)1.98080379
110Febrile seizures (HP:0002373)1.97518914
111Vaginal atresia (HP:0000148)1.96755963
112Thyroiditis (HP:0100646)1.96570025
113Tubular atrophy (HP:0000092)1.94790843
114Cellular immunodeficiency (HP:0005374)1.93806813
115Generalized hypopigmentation of hair (HP:0011358)1.92760908
116Stomach cancer (HP:0012126)1.92568268
117Anencephaly (HP:0002323)1.91202268
118Basal cell carcinoma (HP:0002671)1.91131061
119Neoplasm of striated muscle (HP:0009728)1.90801351
120Abnormality of alanine metabolism (HP:0010916)1.90755353
121Hyperalaninemia (HP:0003348)1.90755353
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90755353
123Nephroblastoma (Wilms tumor) (HP:0002667)1.90444301
1243-Methylglutaconic aciduria (HP:0003535)1.89463107
125Squamous cell carcinoma (HP:0002860)1.88481316
126Urethral obstruction (HP:0000796)1.88463902
127Sparse lateral eyebrow (HP:0005338)1.87573783
128Intestinal atresia (HP:0011100)1.86615084
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86406087
130Long eyelashes (HP:0000527)1.86074184
131Methylmalonic acidemia (HP:0002912)1.85852514
132Cleft eyelid (HP:0000625)1.85708412
133Polydipsia (HP:0001959)1.85616239
134Abnormal drinking behavior (HP:0030082)1.85616239
135Bony spicule pigmentary retinopathy (HP:0007737)1.85392347
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.85068097
137Astigmatism (HP:0000483)1.84784090
138Postaxial foot polydactyly (HP:0001830)1.84331304
139Shawl scrotum (HP:0000049)1.84160682
140Premature ovarian failure (HP:0008209)1.83860742
141Atresia of the external auditory canal (HP:0000413)1.83398541
142Methylmalonic aciduria (HP:0012120)1.82537156
143Biliary tract neoplasm (HP:0100574)1.82287084
144Absent speech (HP:0001344)1.82172161
145Neoplasm of the adrenal cortex (HP:0100641)1.82144604
146Pulmonary fibrosis (HP:0002206)1.80730202
147Sclerocornea (HP:0000647)1.80462223
148Progressive microcephaly (HP:0000253)1.79886209
149Small hand (HP:0200055)1.79723644
150Excessive salivation (HP:0003781)1.79611215
15111 pairs of ribs (HP:0000878)1.79158552
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.79093567
153Pachygyria (HP:0001302)1.78983170
154Deviation of the thumb (HP:0009603)1.78224219
155Abnormal spermatogenesis (HP:0008669)1.77903092
156Blepharitis (HP:0000498)1.77138939
157Abdominal situs inversus (HP:0003363)1.76947915
158Abnormality of abdominal situs (HP:0011620)1.76947915
159Proximal placement of thumb (HP:0009623)1.76386032
160Embryonal renal neoplasm (HP:0011794)1.76255928
161Rib fusion (HP:0000902)1.75173255
162Lymphoma (HP:0002665)1.74935954
163Postaxial hand polydactyly (HP:0001162)1.74841467
164Dandy-Walker malformation (HP:0001305)1.74798368
165Furrowed tongue (HP:0000221)1.74341065
166High pitched voice (HP:0001620)1.73799357
167Arteriovenous malformation (HP:0100026)1.73621863
168Freckling (HP:0001480)1.73370631
169Abnormal rod and cone electroretinograms (HP:0008323)1.72536976
170Pendular nystagmus (HP:0012043)1.72378574
171Anal stenosis (HP:0002025)1.72314406
172Widely spaced teeth (HP:0000687)1.71710084
173Congenital hepatic fibrosis (HP:0002612)1.71449128
174Thyroid-stimulating hormone excess (HP:0002925)1.70213228
175Male pseudohermaphroditism (HP:0000037)1.69461592
176Dyskinesia (HP:0100660)1.69338473
177Oculomotor apraxia (HP:0000657)1.69333216
178Choanal atresia (HP:0000453)1.67307599
179Hypothermia (HP:0002045)1.66980614
180Hypoplastic labia majora (HP:0000059)1.66761066
181Poikiloderma (HP:0001029)1.66731951
182Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66672309
183Facial hemangioma (HP:0000329)1.66424214
184Hypoplasia of the radius (HP:0002984)1.65065011
185Pallor (HP:0000980)1.64870044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.60385091
2CDC74.61412673
3BUB13.54893419
4MAP4K23.47386721
5NEK23.24704113
6WEE13.22418069
7TTK2.98555070
8CDK122.95257279
9PLK42.89392053
10BMPR1B2.78689836
11SRPK12.57097982
12PINK12.42564927
13WNK32.33980904
14EIF2AK12.28468793
15CHEK22.22723432
16MAP3K42.20303463
17PLK12.19661771
18CDK82.03334972
19ATR2.02905729
20ZAK1.97072782
21VRK11.95074561
22ADRBK21.93148853
23AURKB1.92705841
24TRIM281.91027920
25MAPK131.87175025
26PLK31.84115705
27CDK71.80670403
28LATS11.73998146
29BRSK21.64678979
30TSSK61.63124088
31STK31.61015911
32MKNK11.60999774
33CASK1.59771288
34GRK11.59351368
35NEK11.56932222
36RPS6KB21.49764568
37EEF2K1.45820277
38CDK41.45476691
39RPS6KA41.44700024
40TLK11.44535710
41MKNK21.44015724
42MAP3K61.43136086
43STK41.42168186
44CHEK11.41838070
45LATS21.36062223
46CAMKK21.36033731
47DYRK31.34246250
48ERBB31.33808114
49ATM1.32497692
50MAP2K71.30991963
51CCNB11.30490327
52STK38L1.28461551
53INSRR1.25760258
54PIM11.25475041
55PASK1.22655090
56MELK1.22061197
57BRAF1.21927405
58STK101.21138538
59ACVR1B1.20255218
60BRD41.20060576
61CSNK1G11.19671857
62TNIK1.19097707
63MAP3K81.18984804
64BCR1.16370601
65CDK91.15632075
66BRSK11.15476277
67PAK31.10235671
68EIF2AK31.09979943
69WNK41.09604202
70AURKA1.09499615
71CSNK1G31.08831480
72CSNK1G21.03846158
73STK391.03741911
74EPHA21.03591677
75CDK21.02590492
76MARK11.01850817
77CSNK1A1L1.00124818
78NME20.97782946
79EIF2AK20.97735484
80OXSR10.96578689
81OBSCN0.96335525
82NLK0.92045106
83AKT30.81455596
84CDK10.80491311
85STK240.78948256
86CDK60.76514648
87STK160.76012881
88CDK190.73977765
89TRPM70.71337217
90RPS6KA50.69224652
91PLK20.68402169
92MST40.68273042
93NEK90.67013377
94EPHA30.66811566
95PRKCE0.62935281
96PIK3CG0.62544071
97PTK2B0.61820342
98PRKCQ0.61189668
99MUSK0.60367046
100BTK0.59887830
101FLT30.59386706
102MAPKAPK30.57151105
103IRAK10.56484106
104DYRK1A0.56069477
105CSNK2A20.55723896
106MTOR0.55327129
107NUAK10.54667984
108TAOK30.54170374
109CDK30.51970713
110CSNK2A10.50896306
111SGK20.50706400
112TXK0.50518876
113MAPK110.50322071
114ADRBK10.49763052
115JAK30.49413825
116PRKCG0.49388875
117RAF10.48162625
118ITK0.47177061
119PKN10.46998852
120TGFBR10.46216053
121SYK0.45671465
122MAPK140.44867463
123AKT20.44849391
124CHUK0.44265474
125AKT10.43140765
126PIK3CA0.43111950
127PAK40.43069460
128SCYL20.43014096
129PRKAA20.42078225
130DYRK20.41767918
131ALK0.40221289
132PRKDC0.40204588
133CSNK1E0.39694400
134NTRK30.39438756
135MAP2K40.39090876
136CAMK1G0.36992402
137MOS0.36611807
138NEK60.36608766
139IRAK30.36570312
140PRKCI0.36548000
141CAMK2A0.36320042
142PRKAA10.35878888
143CSNK1D0.35096236
144PRKACA0.34341704
145GSK3B0.32447308
146CAMK1D0.32419021
147CSNK1A10.32137420
148MAPKAPK50.32123839
149TEC0.31316199
150PRKCB0.30524966
151PAK10.30084576
152KIT0.30021124
153ERBB40.29907444
154MAP2K30.29858091
155DAPK20.29855887
156MAPK10.29593270
157PHKG20.29517552
158PHKG10.29517552
159ABL10.29214427
160MARK30.28996372
161TESK20.28787949
162MAPK100.28754432
163MAP3K50.28678207

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.39331286
2DNA replication_Homo sapiens_hsa030304.28298398
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78327355
4Homologous recombination_Homo sapiens_hsa034403.48431070
5Cell cycle_Homo sapiens_hsa041103.39200328
6RNA transport_Homo sapiens_hsa030133.07423727
7Fanconi anemia pathway_Homo sapiens_hsa034602.98301897
8Base excision repair_Homo sapiens_hsa034102.93645562
9RNA polymerase_Homo sapiens_hsa030202.88146201
10Phototransduction_Homo sapiens_hsa047442.77810050
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70365489
12Spliceosome_Homo sapiens_hsa030402.70047569
13Nucleotide excision repair_Homo sapiens_hsa034202.65119585
14Basal transcription factors_Homo sapiens_hsa030222.47268729
15Non-homologous end-joining_Homo sapiens_hsa034502.45791600
16One carbon pool by folate_Homo sapiens_hsa006702.40716441
17Protein export_Homo sapiens_hsa030602.35015861
18RNA degradation_Homo sapiens_hsa030182.26300648
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25228379
20Butanoate metabolism_Homo sapiens_hsa006502.22887346
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08092985
22Pyrimidine metabolism_Homo sapiens_hsa002402.06341149
23p53 signaling pathway_Homo sapiens_hsa041152.04974421
24Propanoate metabolism_Homo sapiens_hsa006401.98484599
25Ribosome_Homo sapiens_hsa030101.97330694
26mRNA surveillance pathway_Homo sapiens_hsa030151.96718537
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92205529
28Nicotine addiction_Homo sapiens_hsa050331.74700857
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72361023
30Proteasome_Homo sapiens_hsa030501.68212089
31Systemic lupus erythematosus_Homo sapiens_hsa053221.67405521
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64712043
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60940161
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59665308
35Circadian rhythm_Homo sapiens_hsa047101.57634747
36Olfactory transduction_Homo sapiens_hsa047401.56500120
37Linoleic acid metabolism_Homo sapiens_hsa005911.52158807
38Nitrogen metabolism_Homo sapiens_hsa009101.48384080
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45434745
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44779796
41Oxidative phosphorylation_Homo sapiens_hsa001901.42846164
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35966392
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34026036
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33379221
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29556209
46Ether lipid metabolism_Homo sapiens_hsa005651.25585049
47ABC transporters_Homo sapiens_hsa020101.24646310
48Purine metabolism_Homo sapiens_hsa002301.23106587
49Herpes simplex infection_Homo sapiens_hsa051681.20678428
50Oocyte meiosis_Homo sapiens_hsa041141.19369039
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18020563
52Taste transduction_Homo sapiens_hsa047421.14940496
53Viral carcinogenesis_Homo sapiens_hsa052031.13604988
54Epstein-Barr virus infection_Homo sapiens_hsa051691.12523988
55MicroRNAs in cancer_Homo sapiens_hsa052061.08650404
56Parkinsons disease_Homo sapiens_hsa050121.05160947
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.03271521
58Caffeine metabolism_Homo sapiens_hsa002321.00841351
59HTLV-I infection_Homo sapiens_hsa051660.98902852
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98185008
61Peroxisome_Homo sapiens_hsa041460.97944092
62Morphine addiction_Homo sapiens_hsa050320.97642970
63Tryptophan metabolism_Homo sapiens_hsa003800.95207962
64Vitamin B6 metabolism_Homo sapiens_hsa007500.91940339
65Huntingtons disease_Homo sapiens_hsa050160.87486539
66Colorectal cancer_Homo sapiens_hsa052100.84292299
67TGF-beta signaling pathway_Homo sapiens_hsa043500.83752563
68Small cell lung cancer_Homo sapiens_hsa052220.77735176
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.77634976
70GABAergic synapse_Homo sapiens_hsa047270.77429772
71Serotonergic synapse_Homo sapiens_hsa047260.77144601
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76998144
73Antigen processing and presentation_Homo sapiens_hsa046120.74218140
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73436820
75Dorso-ventral axis formation_Homo sapiens_hsa043200.71896390
76Alcoholism_Homo sapiens_hsa050340.71698052
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.67300668
78Thyroid cancer_Homo sapiens_hsa052160.66718707
79Circadian entrainment_Homo sapiens_hsa047130.66006129
80Hepatitis B_Homo sapiens_hsa051610.63357934
81Fatty acid biosynthesis_Homo sapiens_hsa000610.62095033
82Glutamatergic synapse_Homo sapiens_hsa047240.61625098
83Measles_Homo sapiens_hsa051620.61515798
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.61474148
85Notch signaling pathway_Homo sapiens_hsa043300.60627403
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60355041
87Hippo signaling pathway_Homo sapiens_hsa043900.60209357
88Retinol metabolism_Homo sapiens_hsa008300.59200173
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58434997
90Collecting duct acid secretion_Homo sapiens_hsa049660.58020377
91Chronic myeloid leukemia_Homo sapiens_hsa052200.57574802
92Long-term depression_Homo sapiens_hsa047300.56156887
93Influenza A_Homo sapiens_hsa051640.55872623
94Apoptosis_Homo sapiens_hsa042100.55650308
95Steroid biosynthesis_Homo sapiens_hsa001000.53969882
96Dopaminergic synapse_Homo sapiens_hsa047280.53925465
97Basal cell carcinoma_Homo sapiens_hsa052170.52998509
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52684175
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51332727
100Chemical carcinogenesis_Homo sapiens_hsa052040.51257196
101Glycerolipid metabolism_Homo sapiens_hsa005610.50331139
102Metabolic pathways_Homo sapiens_hsa011000.50316812
103Alzheimers disease_Homo sapiens_hsa050100.47370970
104Pancreatic cancer_Homo sapiens_hsa052120.46508469
105Calcium signaling pathway_Homo sapiens_hsa040200.45980317
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45877037
107Hematopoietic cell lineage_Homo sapiens_hsa046400.45346442
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44725271
109Primary immunodeficiency_Homo sapiens_hsa053400.44510296
110Pathways in cancer_Homo sapiens_hsa052000.41473874
111FoxO signaling pathway_Homo sapiens_hsa040680.41458376
112Salivary secretion_Homo sapiens_hsa049700.41384715
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40275734
114mTOR signaling pathway_Homo sapiens_hsa041500.40224007
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40072405
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39565263
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39274914
118HIF-1 signaling pathway_Homo sapiens_hsa040660.39204772
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38288482
120T cell receptor signaling pathway_Homo sapiens_hsa046600.38269810
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.38153127
122Adherens junction_Homo sapiens_hsa045200.37458527
123Insulin secretion_Homo sapiens_hsa049110.37325282
124Lysine degradation_Homo sapiens_hsa003100.36894399
125Ovarian steroidogenesis_Homo sapiens_hsa049130.36471247
126Legionellosis_Homo sapiens_hsa051340.36090393
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36054886
128Sphingolipid metabolism_Homo sapiens_hsa006000.35098759
129Prostate cancer_Homo sapiens_hsa052150.34003810
130Wnt signaling pathway_Homo sapiens_hsa043100.33933620
131Acute myeloid leukemia_Homo sapiens_hsa052210.33376851
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32408337
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32110730
134Bladder cancer_Homo sapiens_hsa052190.31984146
135Melanoma_Homo sapiens_hsa052180.31835464
136Non-small cell lung cancer_Homo sapiens_hsa052230.29308580
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.29149126
138Shigellosis_Homo sapiens_hsa051310.28526560
139Pentose phosphate pathway_Homo sapiens_hsa000300.25625629
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.25503243
141Endometrial cancer_Homo sapiens_hsa052130.23045476
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22998505
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.21969166
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.21539397
145Platelet activation_Homo sapiens_hsa046110.20780353
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20758462
147Regulation of autophagy_Homo sapiens_hsa041400.19625334
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19115899
149Leishmaniasis_Homo sapiens_hsa051400.18966902
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18854968
151Prolactin signaling pathway_Homo sapiens_hsa049170.18578320
152Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16193130
153Folate biosynthesis_Homo sapiens_hsa007900.15890376
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15244422
155Selenocompound metabolism_Homo sapiens_hsa004500.14428754
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14280692
157TNF signaling pathway_Homo sapiens_hsa046680.14267312
158Biosynthesis of amino acids_Homo sapiens_hsa012300.14154193
159N-Glycan biosynthesis_Homo sapiens_hsa005100.13316456
160Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13253204
161Arachidonic acid metabolism_Homo sapiens_hsa005900.12472497
162Toxoplasmosis_Homo sapiens_hsa051450.11806230
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11538561
164Viral myocarditis_Homo sapiens_hsa054160.11037689

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