MCM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.58902883
2* DNA unwinding involved in DNA replication (GO:0006268)5.56147523
3* DNA strand elongation (GO:0022616)5.31966920
4telomere maintenance via semi-conservative replication (GO:0032201)5.25859910
5* DNA replication initiation (GO:0006270)5.24250583
6telomere maintenance via recombination (GO:0000722)4.76376451
7mitotic recombination (GO:0006312)4.63488505
8DNA replication checkpoint (GO:0000076)4.62954865
9protein localization to kinetochore (GO:0034501)4.51595966
10IMP biosynthetic process (GO:0006188)4.41327147
11nuclear pore organization (GO:0006999)4.40619681
12nuclear pore complex assembly (GO:0051292)4.29896548
13nucleobase biosynthetic process (GO:0046112)4.22178662
14telomere maintenance via telomere lengthening (GO:0010833)4.20500223
15DNA replication-dependent nucleosome organization (GO:0034723)4.19216543
16DNA replication-dependent nucleosome assembly (GO:0006335)4.19216543
17nucleotide-excision repair, DNA gap filling (GO:0006297)4.15327386
18regulation of translational fidelity (GO:0006450)4.11598209
19mitotic nuclear envelope disassembly (GO:0007077)4.06825679
20folic acid-containing compound biosynthetic process (GO:0009396)4.03024355
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94892979
22chromatin remodeling at centromere (GO:0031055)3.92325508
23non-recombinational repair (GO:0000726)3.90412486
24double-strand break repair via nonhomologous end joining (GO:0006303)3.90412486
25CENP-A containing nucleosome assembly (GO:0034080)3.90376123
26IMP metabolic process (GO:0046040)3.88866391
27kinetochore organization (GO:0051383)3.87052399
28mitotic chromosome condensation (GO:0007076)3.85778587
29protein localization to chromosome, centromeric region (GO:0071459)3.85032533
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77098709
31membrane disassembly (GO:0030397)3.76705057
32nuclear envelope disassembly (GO:0051081)3.76705057
33mitotic metaphase plate congression (GO:0007080)3.75834066
34purine nucleobase biosynthetic process (GO:0009113)3.75571063
35DNA ligation (GO:0006266)3.72305884
36DNA replication-independent nucleosome assembly (GO:0006336)3.69775982
37DNA replication-independent nucleosome organization (GO:0034724)3.69775982
38ribosomal small subunit assembly (GO:0000028)3.68847168
39formation of translation preinitiation complex (GO:0001731)3.68473778
40* DNA duplex unwinding (GO:0032508)3.66838530
41* DNA geometric change (GO:0032392)3.65752104
42establishment of viral latency (GO:0019043)3.58595818
43chromosome condensation (GO:0030261)3.57892267
44somatic hypermutation of immunoglobulin genes (GO:0016446)3.57656949
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57656949
46mitotic sister chromatid segregation (GO:0000070)3.56841063
47protein complex localization (GO:0031503)3.55028490
48regulation of centriole replication (GO:0046599)3.49469131
49maturation of SSU-rRNA (GO:0030490)3.47659441
50sister chromatid segregation (GO:0000819)3.46421448
51translesion synthesis (GO:0019985)3.45477989
52mitotic sister chromatid cohesion (GO:0007064)3.44008480
53metaphase plate congression (GO:0051310)3.42921453
54attachment of spindle microtubules to kinetochore (GO:0008608)3.40953076
55telomere maintenance (GO:0000723)3.38313427
56telomere organization (GO:0032200)3.36473730
57pore complex assembly (GO:0046931)3.34012683
58mismatch repair (GO:0006298)3.33912665
59L-serine metabolic process (GO:0006563)3.31854594
60DNA synthesis involved in DNA repair (GO:0000731)3.29835224
61histone exchange (GO:0043486)3.28264258
62negative regulation of mRNA metabolic process (GO:1903312)3.27001433
63kinetochore assembly (GO:0051382)3.24223721
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23925872
65establishment of chromosome localization (GO:0051303)3.23866190
66chromatin assembly or disassembly (GO:0006333)3.23524557
67postreplication repair (GO:0006301)3.22260826
68meiotic chromosome segregation (GO:0045132)3.20972651
69heterochromatin organization (GO:0070828)3.17845355
70DNA packaging (GO:0006323)3.17247533
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.13961677
72chromosome segregation (GO:0007059)3.13801809
73spliceosomal tri-snRNP complex assembly (GO:0000244)3.12848568
74chromatin assembly (GO:0031497)3.12080271
75cellular protein complex localization (GO:0034629)3.11466669
76nucleobase-containing small molecule interconversion (GO:0015949)3.11311867
77positive regulation of chromosome segregation (GO:0051984)3.11098623
78* DNA conformation change (GO:0071103)3.10928814
79viral mRNA export from host cell nucleus (GO:0046784)3.10062499
80regulation of histone H3-K9 methylation (GO:0051570)3.08982569
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.07339294
82ribosome biogenesis (GO:0042254)3.05725344
83negative regulation of RNA splicing (GO:0033119)3.05301022
84base-excision repair (GO:0006284)3.04618677
85regulation of spindle organization (GO:0090224)3.03654938
86ribosome assembly (GO:0042255)3.03573729
87dosage compensation (GO:0007549)3.02807108
88V(D)J recombination (GO:0033151)3.02801870
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01672848
90peptidyl-arginine omega-N-methylation (GO:0035247)2.99723109
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97022022
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97022022
93regulation of translational termination (GO:0006449)2.96929067
94transcription-coupled nucleotide-excision repair (GO:0006283)2.96334276
95DNA topological change (GO:0006265)2.95866471
96ATP-dependent chromatin remodeling (GO:0043044)2.95545514
97viral transcription (GO:0019083)2.95372332
98regulation of centrosome cycle (GO:0046605)2.95067067
99translational termination (GO:0006415)2.93829023
100DNA strand renaturation (GO:0000733)2.93804804
101* DNA replication (GO:0006260)2.93215783
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92254384
103regulation of helicase activity (GO:0051095)2.92101149
104ribonucleoprotein complex biogenesis (GO:0022613)2.90186230
105negative regulation of mRNA processing (GO:0050686)2.88776378
106nuclear envelope organization (GO:0006998)2.88388785
107negative regulation of chromosome segregation (GO:0051985)2.88231844
108regulation of chromosome segregation (GO:0051983)2.87989192
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87679892
110mRNA splicing, via spliceosome (GO:0000398)2.87679892
111RNA splicing, via transesterification reactions (GO:0000375)2.87354023
112intra-S DNA damage checkpoint (GO:0031573)2.87153495
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86704885
114protein localization to chromosome (GO:0034502)2.86685843
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86404178
116establishment of integrated proviral latency (GO:0075713)2.85934706
117regulation of sister chromatid cohesion (GO:0007063)2.85909963
118spindle checkpoint (GO:0031577)2.85615691
119ribosomal large subunit biogenesis (GO:0042273)2.85362033
120* G1/S transition of mitotic cell cycle (GO:0000082)2.84646701
121* cell cycle G1/S phase transition (GO:0044843)2.84646701
122protein K6-linked ubiquitination (GO:0085020)2.84426078
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.84288002
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84288002
125negative regulation of sister chromatid segregation (GO:0033046)2.84288002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.43822376
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19857299
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02266689
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49544462
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29832553
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80714060
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66307406
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57375619
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.53391133
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50037249
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.48299271
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.36691463
13* AR_21909140_ChIP-Seq_LNCAP_Human2.33053027
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30073476
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19787338
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.17545278
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.17054472
18XRN2_22483619_ChIP-Seq_HELA_Human2.14412252
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05509719
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01126657
21* E2F7_22180533_ChIP-Seq_HELA_Human11.2154200
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98243491
23MYC_22102868_ChIP-Seq_BL_Human1.94918741
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94690837
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93241682
26* VDR_23849224_ChIP-Seq_CD4+_Human1.91831121
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88939957
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85270476
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.79295000
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77896733
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75907609
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68817505
33DCP1A_22483619_ChIP-Seq_HELA_Human1.66620159
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65744473
35* TTF2_22483619_ChIP-Seq_HELA_Human1.65639662
36* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63558513
37CIITA_25753668_ChIP-Seq_RAJI_Human1.63096363
38GABP_19822575_ChIP-Seq_HepG2_Human1.59398296
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59335316
40ELK1_19687146_ChIP-ChIP_HELA_Human1.55743798
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54327505
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54031767
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50035222
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49606363
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49225995
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48368438
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.44088734
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43281650
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40945218
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39104104
51KDM5A_27292631_Chip-Seq_BREAST_Human1.36191472
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31257839
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31035858
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28786785
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28219759
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27345319
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21752528
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21546469
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20830600
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20151209
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19648905
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19275828
63VDR_21846776_ChIP-Seq_THP-1_Human1.18122120
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14721827
65ZNF263_19887448_ChIP-Seq_K562_Human1.14438012
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13222772
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.13065690
68TFEB_21752829_ChIP-Seq_HELA_Human1.12815708
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12592552
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11452202
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11057342
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07595480
73* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06865554
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05827336
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.02609842
76* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01812242
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00902312
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00001527
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.99406521
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97377541
81CHD1_26751641_Chip-Seq_LNCaP_Human0.95449022
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94907137
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94808458
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94720720
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94621843
86SPI1_23547873_ChIP-Seq_NB4_Human0.94572545
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.92083677
88MYC_18940864_ChIP-ChIP_HL60_Human0.91348141
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90711585
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.90521334
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89674192
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.87124561
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85035559
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83393737
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83358525
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83319949
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82888524
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81821702
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81225716
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.79913081
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.79874321
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79527932
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78720869
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78511869
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76346804
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76212307
107MYB_26560356_Chip-Seq_TH1_Human0.74515726
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74142169
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73858612
110MYB_26560356_Chip-Seq_TH2_Human0.73835931
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73600967
112UTX_26944678_Chip-Seq_JUKART_Human0.72992801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.83646984
2MP0003693_abnormal_embryo_hatching4.59898815
3MP0008057_abnormal_DNA_replication4.57702689
4* MP0003111_abnormal_nucleus_morphology4.12731992
5MP0004957_abnormal_blastocyst_morpholog4.05478652
6* MP0003077_abnormal_cell_cycle3.79357679
7MP0008058_abnormal_DNA_repair3.17092176
8MP0002396_abnormal_hematopoietic_system2.90293242
9MP0010352_gastrointestinal_tract_polyps2.79616996
10MP0008007_abnormal_cellular_replicative2.74199602
11MP0003123_paternal_imprinting2.72954793
12* MP0008932_abnormal_embryonic_tissue2.37865381
13MP0001730_embryonic_growth_arrest2.29071474
14* MP0000350_abnormal_cell_proliferation2.23969207
15MP0008877_abnormal_DNA_methylation2.12981952
16MP0010307_abnormal_tumor_latency2.07817401
17MP0002877_abnormal_melanocyte_morpholog1.99558910
18MP0009697_abnormal_copulation1.93002130
19MP0004808_abnormal_hematopoietic_stem1.87360072
20MP0000490_abnormal_crypts_of1.84553183
21MP0003121_genomic_imprinting1.75803892
22MP0001697_abnormal_embryo_size1.73703141
23* MP0001672_abnormal_embryogenesis/_devel1.73047396
24* MP0005380_embryogenesis_phenotype1.73047396
25MP0002009_preneoplasia1.70447174
26MP0003786_premature_aging1.68862395
27* MP0003984_embryonic_growth_retardation1.57044191
28MP0003941_abnormal_skin_development1.54973919
29MP0002085_abnormal_embryonic_tissue1.54413869
30* MP0002080_prenatal_lethality1.54255622
31* MP0002088_abnormal_embryonic_growth/wei1.54033573
32MP0004185_abnormal_adipocyte_glucose1.51545829
33MP0006054_spinal_hemorrhage1.51154735
34MP0001346_abnormal_lacrimal_gland1.49882829
35* MP0004197_abnormal_fetal_growth/weight/1.49481091
36MP0002086_abnormal_extraembryonic_tissu1.48793335
37MP0002084_abnormal_developmental_patter1.48717749
38* MP0002019_abnormal_tumor_incidence1.48028290
39MP0003763_abnormal_thymus_physiology1.46069098
40MP0003567_abnormal_fetal_cardiomyocyte1.44235994
41MP0000313_abnormal_cell_death1.43074256
42MP0010234_abnormal_vibrissa_follicle1.39892800
43MP0005076_abnormal_cell_differentiation1.39735099
44MP0001545_abnormal_hematopoietic_system1.33307747
45MP0005397_hematopoietic_system_phenotyp1.33307747
46MP0002697_abnormal_eye_size1.30899823
47MP0000703_abnormal_thymus_morphology1.29448087
48MP0010030_abnormal_orbit_morphology1.27516522
49MP0003890_abnormal_embryonic-extraembry1.26282367
50* MP0002398_abnormal_bone_marrow1.23204119
51MP0004233_abnormal_muscle_weight1.23075940
52MP0001661_extended_life_span1.20177031
53MP0009333_abnormal_splenocyte_physiolog1.19370622
54MP0001293_anophthalmia1.14476350
55MP0002722_abnormal_immune_system1.13891257
56MP0003315_abnormal_perineum_morphology1.10774456
57MP0005501_abnormal_skin_physiology1.09373827
58MP0000689_abnormal_spleen_morphology1.09289456
59MP0006035_abnormal_mitochondrial_morpho1.05522906
60MP0009278_abnormal_bone_marrow1.04362644
61MP0002210_abnormal_sex_determination1.04282716
62MP0003705_abnormal_hypodermis_morpholog0.99329352
63MP0000537_abnormal_urethra_morphology0.99106695
64MP0009053_abnormal_anal_canal0.98075058
65MP0009672_abnormal_birth_weight0.93616787
66* MP0002429_abnormal_blood_cell0.92261695
67MP0000858_altered_metastatic_potential0.91942239
68MP0001145_abnormal_male_reproductive0.90595753
69MP0002796_impaired_skin_barrier0.89584110
70MP0005023_abnormal_wound_healing0.88994908
71MP0001915_intracranial_hemorrhage0.88716903
72MP0002160_abnormal_reproductive_system0.87131326
73MP0000566_synostosis0.84913996
74MP0003566_abnormal_cell_adhesion0.84530696
75MP0001119_abnormal_female_reproductive0.82326456
76MP0002111_abnormal_tail_morphology0.81760389
77MP0003718_maternal_effect0.81264212
78MP0000716_abnormal_immune_system0.80689940
79MP0005623_abnormal_meninges_morphology0.79677983
80MP0003861_abnormal_nervous_system0.78788851
81MP0009703_decreased_birth_body0.77800601
82MP0000653_abnormal_sex_gland0.76880278
83MP0005384_cellular_phenotype0.76689377
84MP0003937_abnormal_limbs/digits/tail_de0.76614840
85MP0000579_abnormal_nail_morphology0.76156404
86MP0003385_abnormal_body_wall0.75651672
87MP0003806_abnormal_nucleotide_metabolis0.74928913
88MP0005621_abnormal_cell_physiology0.72992238
89MP0000477_abnormal_intestine_morphology0.72572032
90MP0001929_abnormal_gametogenesis0.71987371
91MP0002938_white_spotting0.71438965
92MP0002006_tumorigenesis0.69431492
93MP0001800_abnormal_humoral_immune0.68559287
94MP0005389_reproductive_system_phenotype0.67977609
95MP0000428_abnormal_craniofacial_morphol0.66966353
96MP0002405_respiratory_system_inflammati0.66512648
97MP0001853_heart_inflammation0.65902978
98MP0002420_abnormal_adaptive_immunity0.64539001
99MP0002092_abnormal_eye_morphology0.63638106
100MP0002075_abnormal_coat/hair_pigmentati0.62988471
101MP0001819_abnormal_immune_cell0.62910657
102MP0001286_abnormal_eye_development0.62769772
103MP0001835_abnormal_antigen_presentation0.62759912
104MP0000358_abnormal_cell_content/0.62683383
105MP0003943_abnormal_hepatobiliary_system0.62323806
106MP0001881_abnormal_mammary_gland0.62273421
107MP0002233_abnormal_nose_morphology0.62125024
108MP0000432_abnormal_head_morphology0.61909676
109MP0004133_heterotaxia0.61890844
110MP0003448_altered_tumor_morphology0.61745203
111MP0003935_abnormal_craniofacial_develop0.61700699
112MP0001727_abnormal_embryo_implantation0.61609815
113MP0002925_abnormal_cardiovascular_devel0.61517195
114MP0003942_abnormal_urinary_system0.61221807
115MP0002452_abnormal_antigen_presenting0.60954231
116MP0002166_altered_tumor_susceptibility0.59950366
117MP0003699_abnormal_female_reproductive0.59598774
118MP0001849_ear_inflammation0.59417326
119MP0002095_abnormal_skin_pigmentation0.57052265
120MP0000465_gastrointestinal_hemorrhage0.56864857
121MP0004264_abnormal_extraembryonic_tissu0.56857489
122MP0003115_abnormal_respiratory_system0.56847844
123MP0000733_abnormal_muscle_development0.56726718
124MP0003755_abnormal_palate_morphology0.55801442
125MP0002114_abnormal_axial_skeleton0.55333521
126MP0000627_abnormal_mammary_gland0.55222809
127MP0006292_abnormal_olfactory_placode0.55219695
128MP0005187_abnormal_penis_morphology0.55174083
129MP0003221_abnormal_cardiomyocyte_apopto0.55064236
130* MP0002081_perinatal_lethality0.54474418
131MP0002163_abnormal_gland_morphology0.54289953
132MP0008995_early_reproductive_senescence0.53999132
133MP0002060_abnormal_skin_morphology0.53843567

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.83979108
2Chromsome breakage (HP:0040012)4.25248167
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91236146
4Reticulocytopenia (HP:0001896)3.74522330
5Colon cancer (HP:0003003)3.64758646
6Medulloblastoma (HP:0002885)3.54484881
7Abnormality of chromosome stability (HP:0003220)3.47731685
8Breast hypoplasia (HP:0003187)3.35552482
9Selective tooth agenesis (HP:0001592)3.32720694
10Ependymoma (HP:0002888)3.31852886
11Meckel diverticulum (HP:0002245)3.24499378
12Patellar aplasia (HP:0006443)3.12950413
13Abnormality of the ileum (HP:0001549)3.10392612
14Abnormality of the preputium (HP:0100587)3.03167471
15Agnosia (HP:0010524)3.02925533
16Microvesicular hepatic steatosis (HP:0001414)3.00358260
17Oral leukoplakia (HP:0002745)3.00234753
18Abnormality of cells of the erythroid lineage (HP:0012130)2.92722642
19Aplasia/Hypoplasia of the patella (HP:0006498)2.92116058
20Multiple enchondromatosis (HP:0005701)2.91417303
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.90212117
22Abnormal number of erythroid precursors (HP:0012131)2.86465137
23Myelodysplasia (HP:0002863)2.76980324
24Degeneration of anterior horn cells (HP:0002398)2.76078355
25Abnormality of the anterior horn cell (HP:0006802)2.76078355
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73819681
27Short 4th metacarpal (HP:0010044)2.73819681
28Ectopic kidney (HP:0000086)2.72628774
29Rhabdomyosarcoma (HP:0002859)2.71848506
30Aplastic anemia (HP:0001915)2.65208648
31Deviation of the thumb (HP:0009603)2.64203046
32Progressive muscle weakness (HP:0003323)2.63448404
33Proximal placement of thumb (HP:0009623)2.62994645
34Small intestinal stenosis (HP:0012848)2.62035810
35Duodenal stenosis (HP:0100867)2.62035810
3611 pairs of ribs (HP:0000878)2.61397756
37Cortical dysplasia (HP:0002539)2.60132610
38Increased nuchal translucency (HP:0010880)2.59375940
39Absent thumb (HP:0009777)2.59326649
40Abnormal number of incisors (HP:0011064)2.56354039
41Basal cell carcinoma (HP:0002671)2.55180067
42Abnormality of cochlea (HP:0000375)2.51234063
43Volvulus (HP:0002580)2.43862695
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41150003
45Hyperacusis (HP:0010780)2.39701395
46Atresia of the external auditory canal (HP:0000413)2.37325090
47Absent radius (HP:0003974)2.36985264
48Bone marrow hypocellularity (HP:0005528)2.36235601
49Neoplasm of the pancreas (HP:0002894)2.35376186
50High anterior hairline (HP:0009890)2.34367869
51Premature graying of hair (HP:0002216)2.32896517
52Impulsivity (HP:0100710)2.32730771
53Abnormal lung lobation (HP:0002101)2.31330452
54Abnormality of glycolysis (HP:0004366)2.28716999
55High pitched voice (HP:0001620)2.28196451
56Thrombocytosis (HP:0001894)2.27337632
57Abnormality of the carotid arteries (HP:0005344)2.27231540
58Amaurosis fugax (HP:0100576)2.25048358
59Carpal bone hypoplasia (HP:0001498)2.23141001
60Insomnia (HP:0100785)2.20917455
61Overlapping toe (HP:0001845)2.18696689
62Abnormality of the astrocytes (HP:0100707)2.18650877
63Astrocytoma (HP:0009592)2.18650877
64Aplasia involving forearm bones (HP:0009822)2.18137262
65Absent forearm bone (HP:0003953)2.18137262
66Progressive external ophthalmoplegia (HP:0000590)2.17723817
67Abnormality of the labia minora (HP:0012880)2.15925346
68Sloping forehead (HP:0000340)2.15910722
69Slender long bone (HP:0003100)2.13977535
70Duplication of thumb phalanx (HP:0009942)2.13538746
71Lymphoma (HP:0002665)2.12610791
72Choanal atresia (HP:0000453)2.11695397
73Tracheoesophageal fistula (HP:0002575)2.10985036
74Glioma (HP:0009733)2.10691902
75Abnormality of the duodenum (HP:0002246)2.10680259
76IgM deficiency (HP:0002850)2.10634164
77Missing ribs (HP:0000921)2.07402314
78Nephroblastoma (Wilms tumor) (HP:0002667)2.07311642
79Facial cleft (HP:0002006)2.07115529
80Spastic diplegia (HP:0001264)2.06850702
81Neoplasm of striated muscle (HP:0009728)2.05970225
82Cafe-au-lait spot (HP:0000957)2.05469693
83Rough bone trabeculation (HP:0100670)2.05185274
84Deep philtrum (HP:0002002)2.04446393
85Overriding aorta (HP:0002623)2.04092767
86Neoplasm of the oral cavity (HP:0100649)2.04040790
87Duplicated collecting system (HP:0000081)2.00825237
88Pallor (HP:0000980)1.99552249
89Squamous cell carcinoma (HP:0002860)1.98951791
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.96204320
91Clubbing of toes (HP:0100760)1.95335713
92Macrocytic anemia (HP:0001972)1.94892714
93Cellular immunodeficiency (HP:0005374)1.94091062
94Embryonal renal neoplasm (HP:0011794)1.94029102
95Abnormality of the calcaneus (HP:0008364)1.93919936
96Short thumb (HP:0009778)1.93647793
97Triphalangeal thumb (HP:0001199)1.92856454
98Neoplasm of the colon (HP:0100273)1.91415388
99Abnormality of reticulocytes (HP:0004312)1.89903020
100Embryonal neoplasm (HP:0002898)1.86961648
101Biliary tract neoplasm (HP:0100574)1.86396803
102Spinal cord lesions (HP:0100561)1.85642877
103Syringomyelia (HP:0003396)1.85642877
104Increased serum pyruvate (HP:0003542)1.85522136
105Horseshoe kidney (HP:0000085)1.84013816
106Prominent nose (HP:0000448)1.83562144
107Supernumerary spleens (HP:0009799)1.82973997
108Arteriovenous malformation (HP:0100026)1.82935243
109Asplenia (HP:0001746)1.82694511
110Trismus (HP:0000211)1.81789580
111Microretrognathia (HP:0000308)1.81714398
112Abnormality of the fingertips (HP:0001211)1.80021673
113Long eyelashes (HP:0000527)1.79424583
114Abnormality of chromosome segregation (HP:0002916)1.78893075
115Abnormality of DNA repair (HP:0003254)1.78804427
116Abnormality of the 4th metacarpal (HP:0010012)1.78582688
117Abnormality of the renal collecting system (HP:0004742)1.78420294
118Acute myeloid leukemia (HP:0004808)1.78413501
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78406600
120Renal duplication (HP:0000075)1.77257650
121Morphological abnormality of the inner ear (HP:0011390)1.76681113
122Abnormality of abdominal situs (HP:0011620)1.76211261
123Abdominal situs inversus (HP:0003363)1.76211261
124Elfin facies (HP:0004428)1.75733340
125Cutaneous melanoma (HP:0012056)1.75535153
126Septate vagina (HP:0001153)1.73342043
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.73113582
128Pseudobulbar signs (HP:0002200)1.70213926
129Abnormality of the umbilical cord (HP:0010881)1.70028857
130Urethral obstruction (HP:0000796)1.66195799
131Microglossia (HP:0000171)1.65747168
132Ankyloglossia (HP:0010296)1.65712146
133Poikiloderma (HP:0001029)1.64705301
134Abnormal gallbladder physiology (HP:0012438)1.62322925
135Cholecystitis (HP:0001082)1.62322925
136Glossoptosis (HP:0000162)1.62295708
137Premature ovarian failure (HP:0008209)1.58198110
138Abnormality of the salivary glands (HP:0010286)1.57353232
139Ragged-red muscle fibers (HP:0003200)1.56231259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.40637787
2WEE14.08941848
3BUB13.29271705
4EIF2AK12.89699865
5SMG12.79567390
6NEK22.63537519
7VRK22.40444892
8SRPK12.36049224
9PBK2.33484115
10TTK2.26513341
11TSSK62.25556508
12PASK2.23610350
13NEK12.22326300
14CDK122.19760814
15EEF2K2.14290724
16ATR2.02008718
17ACVR1B2.01827130
18MKNK11.95985748
19BRSK21.94427824
20CDK71.91391654
21PLK11.88087473
22PLK41.83899053
23RPS6KB21.81943716
24TAF11.73119356
25AURKB1.68309327
26EIF2AK31.66337654
27TESK21.60694114
28STK101.60274336
29VRK11.59801000
30CDK41.59548964
31TGFBR11.59393456
32RPS6KA41.53443788
33PLK31.52204166
34CHEK21.48521571
35MAP3K81.46206229
36SCYL21.40800902
37NME21.39912933
38MAP3K101.39093578
39TRIB31.31098597
40* CHEK11.29986000
41TLK11.29765104
42MAP4K11.29726481
43BRSK11.23950881
44ICK1.22884650
45DYRK31.20159848
46STK41.19298054
47PKN21.14696224
48MKNK21.14466574
49PAK41.12482075
50AURKA1.07504657
51ATM1.05497392
52CDK81.05360529
53CCNB11.05326877
54PIM11.01029548
55BRD41.00535976
56FLT30.99869902
57CLK10.99789430
58CDK60.95864212
59* CDK20.91726502
60ZAK0.85270993
61NME10.82090818
62LRRK20.78905475
63ALK0.78337787
64STK160.77727591
65MST1R0.77579908
66MELK0.76028210
67EPHA20.72866059
68IRAK30.71805864
69* CDK10.68729385
70BTK0.68571501
71PNCK0.68372265
72LATS20.67032626
73MAP2K30.66858367
74JAK30.65079804
75STK30.64403701
76CSNK2A20.64077452
77NEK90.61217351
78ERBB40.61008526
79CSNK2A10.60764621
80BRAF0.60554946
81DAPK10.60431715
82TESK10.58048587
83TEC0.54097288
84KDR0.54031933
85EIF2AK20.52887339
86CDK150.52061500
87CDK11A0.51860375
88CDK180.51444913
89LATS10.51079224
90PIM20.51038313
91CAMK1D0.49309450
92PAK10.48705796
93TRIM280.46407237
94CSF1R0.45852832
95CDK140.44303385
96MAPKAPK30.42950691
97KIT0.42544746
98MTOR0.42409824
99GRK60.41928050
100CAMK1G0.41795339
101PRKDC0.41479225
102FGFR10.41353086
103RPS6KA50.39536896
104MAPKAPK50.38758734
105MET0.37988108
106PAK20.37763548
107TTN0.36189158
108MAPK110.35851136
109ZAP700.35505326
110CDK30.33843614
111PDK20.32422999
112MAPK140.30820282
113CSNK1G30.30573518
114YES10.30135564
115CSNK1D0.29711223
116MST40.29428927
117CDK90.29194203
118NUAK10.28992974
119GSK3B0.28174120
120AKT20.26942785
121RPS6KC10.26840151
122RPS6KL10.26840151
123AKT10.26770039
124RPS6KA60.26507968
125TRPM70.26268051
126TXK0.26250070
127MAP3K110.26120702
128CSNK1E0.25413833
129PRKCI0.25337605
130ITK0.24206588

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.71188069
2Mismatch repair_Homo sapiens_hsa034304.88237357
3Base excision repair_Homo sapiens_hsa034103.36551301
4Homologous recombination_Homo sapiens_hsa034403.21980278
5Spliceosome_Homo sapiens_hsa030403.18512484
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17326225
7Nucleotide excision repair_Homo sapiens_hsa034203.04304946
8* Cell cycle_Homo sapiens_hsa041103.00211172
9RNA transport_Homo sapiens_hsa030132.91211135
10One carbon pool by folate_Homo sapiens_hsa006702.90333989
11Ribosome_Homo sapiens_hsa030102.60780516
12Non-homologous end-joining_Homo sapiens_hsa034502.42339828
13Fanconi anemia pathway_Homo sapiens_hsa034602.38705811
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37058085
15RNA polymerase_Homo sapiens_hsa030202.35897986
16Proteasome_Homo sapiens_hsa030502.30188735
17Pyrimidine metabolism_Homo sapiens_hsa002402.17525399
18RNA degradation_Homo sapiens_hsa030181.87234135
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84098693
20mRNA surveillance pathway_Homo sapiens_hsa030151.78067925
21p53 signaling pathway_Homo sapiens_hsa041151.67974164
22Basal transcription factors_Homo sapiens_hsa030221.54833039
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45328718
24Systemic lupus erythematosus_Homo sapiens_hsa053221.22486433
25Vitamin B6 metabolism_Homo sapiens_hsa007501.20462428
26Pyruvate metabolism_Homo sapiens_hsa006201.16790677
27Epstein-Barr virus infection_Homo sapiens_hsa051691.13463869
28Viral carcinogenesis_Homo sapiens_hsa052031.13276532
29Herpes simplex infection_Homo sapiens_hsa051681.11107893
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10743274
31Purine metabolism_Homo sapiens_hsa002301.09168177
32Antigen processing and presentation_Homo sapiens_hsa046121.07338050
33HTLV-I infection_Homo sapiens_hsa051660.96630107
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94683512
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91549401
36Oocyte meiosis_Homo sapiens_hsa041140.91484038
37Sulfur relay system_Homo sapiens_hsa041220.90373927
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90311994
39MicroRNAs in cancer_Homo sapiens_hsa052060.87848908
40Primary immunodeficiency_Homo sapiens_hsa053400.86237390
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85011772
42Small cell lung cancer_Homo sapiens_hsa052220.83888192
43Thyroid cancer_Homo sapiens_hsa052160.81719104
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77230274
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72642084
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72222121
47Selenocompound metabolism_Homo sapiens_hsa004500.70205485
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69452139
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69304345
50Legionellosis_Homo sapiens_hsa051340.68632284
51Biosynthesis of amino acids_Homo sapiens_hsa012300.68283725
52Measles_Homo sapiens_hsa051620.64087288
53Pentose phosphate pathway_Homo sapiens_hsa000300.61912246
54Chronic myeloid leukemia_Homo sapiens_hsa052200.60591404
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.59987289
56Hepatitis B_Homo sapiens_hsa051610.59766116
57Fructose and mannose metabolism_Homo sapiens_hsa000510.59687164
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.59545663
59Colorectal cancer_Homo sapiens_hsa052100.57763412
60Steroid biosynthesis_Homo sapiens_hsa001000.55532336
61Apoptosis_Homo sapiens_hsa042100.55134374
62Viral myocarditis_Homo sapiens_hsa054160.53797094
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.50888395
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.50788043
65TGF-beta signaling pathway_Homo sapiens_hsa043500.50563600
66Shigellosis_Homo sapiens_hsa051310.49448033
67Basal cell carcinoma_Homo sapiens_hsa052170.49095991
68Fatty acid elongation_Homo sapiens_hsa000620.48278190
69Hippo signaling pathway_Homo sapiens_hsa043900.48074975
70Folate biosynthesis_Homo sapiens_hsa007900.47566938
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46908957
72Galactose metabolism_Homo sapiens_hsa000520.43832610
73Notch signaling pathway_Homo sapiens_hsa043300.43381924
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43152316
75Adherens junction_Homo sapiens_hsa045200.43001464
76Bladder cancer_Homo sapiens_hsa052190.42808210
77N-Glycan biosynthesis_Homo sapiens_hsa005100.42393154
78Huntingtons disease_Homo sapiens_hsa050160.42157890
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41666598
80Alcoholism_Homo sapiens_hsa050340.41313306
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38308643
82Pathways in cancer_Homo sapiens_hsa052000.37996642
83Hematopoietic cell lineage_Homo sapiens_hsa046400.36966093
84Non-small cell lung cancer_Homo sapiens_hsa052230.36806435
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36738102
86Influenza A_Homo sapiens_hsa051640.36006762
87Prostate cancer_Homo sapiens_hsa052150.35734091
88Propanoate metabolism_Homo sapiens_hsa006400.35388257
89Pancreatic cancer_Homo sapiens_hsa052120.35156214
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34724508
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32708771
92Acute myeloid leukemia_Homo sapiens_hsa052210.32341787
93Wnt signaling pathway_Homo sapiens_hsa043100.31892296
94HIF-1 signaling pathway_Homo sapiens_hsa040660.30596001
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.29356484
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28261730
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.27672529
98Leishmaniasis_Homo sapiens_hsa051400.27502679
99Arginine and proline metabolism_Homo sapiens_hsa003300.27265773
100Metabolic pathways_Homo sapiens_hsa011000.26833337
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.26677868
102Fatty acid metabolism_Homo sapiens_hsa012120.26270403
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26248386
104Glutathione metabolism_Homo sapiens_hsa004800.26183872
105Glioma_Homo sapiens_hsa052140.26062080
106Carbon metabolism_Homo sapiens_hsa012000.25635317
107Lysine degradation_Homo sapiens_hsa003100.25459588
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24303763
109Arginine biosynthesis_Homo sapiens_hsa002200.23568555
110Parkinsons disease_Homo sapiens_hsa050120.23563341
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23482423
112Protein export_Homo sapiens_hsa030600.23331092
113Endometrial cancer_Homo sapiens_hsa052130.23276359
114B cell receptor signaling pathway_Homo sapiens_hsa046620.22375151
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21642883
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21403501
117Proteoglycans in cancer_Homo sapiens_hsa052050.21078830
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20727719
119Hedgehog signaling pathway_Homo sapiens_hsa043400.20345370
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20175080
121T cell receptor signaling pathway_Homo sapiens_hsa046600.19495854
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17447692
123mTOR signaling pathway_Homo sapiens_hsa041500.17029966
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.16470417
125Melanoma_Homo sapiens_hsa052180.16136105
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15705385
127Toxoplasmosis_Homo sapiens_hsa051450.15551339
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15502684
129Renin-angiotensin system_Homo sapiens_hsa046140.15307468
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14673229
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13990905
132Tight junction_Homo sapiens_hsa045300.12434017

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