MCM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.19646273
2* DNA strand elongation involved in DNA replication (GO:0006271)5.66226631
3* DNA strand elongation (GO:0022616)5.37780249
4telomere maintenance via semi-conservative replication (GO:0032201)5.27097541
5* DNA replication initiation (GO:0006270)5.25669303
6protein localization to kinetochore (GO:0034501)4.81695072
7telomere maintenance via recombination (GO:0000722)4.68590097
8DNA replication checkpoint (GO:0000076)4.59676252
9mitotic recombination (GO:0006312)4.50511985
10IMP biosynthetic process (GO:0006188)4.45081453
11nucleobase biosynthetic process (GO:0046112)4.37244636
12DNA replication-dependent nucleosome assembly (GO:0006335)4.27561769
13DNA replication-dependent nucleosome organization (GO:0034723)4.27561769
14folic acid-containing compound biosynthetic process (GO:0009396)4.23584309
15nuclear pore organization (GO:0006999)4.21987294
16telomere maintenance via telomere lengthening (GO:0010833)4.16189683
17mitotic nuclear envelope disassembly (GO:0007077)4.12784430
18nucleotide-excision repair, DNA gap filling (GO:0006297)4.12683336
19ribosomal small subunit assembly (GO:0000028)4.09234494
20nuclear pore complex assembly (GO:0051292)4.07092968
21formation of translation preinitiation complex (GO:0001731)4.01069017
22protein localization to chromosome, centromeric region (GO:0071459)4.00780107
23IMP metabolic process (GO:0046040)3.94329214
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87323401
25purine nucleobase biosynthetic process (GO:0009113)3.85189357
26establishment of viral latency (GO:0019043)3.82865831
27membrane disassembly (GO:0030397)3.81563714
28nuclear envelope disassembly (GO:0051081)3.81563714
29maturation of SSU-rRNA (GO:0030490)3.81512653
30non-recombinational repair (GO:0000726)3.79552556
31double-strand break repair via nonhomologous end joining (GO:0006303)3.79552556
32mitotic metaphase plate congression (GO:0007080)3.76843957
33* DNA duplex unwinding (GO:0032508)3.74988060
34* DNA geometric change (GO:0032392)3.73516600
35DNA ligation (GO:0006266)3.72980447
36chromatin remodeling at centromere (GO:0031055)3.70761929
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.69265901
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69265901
39CENP-A containing nucleosome assembly (GO:0034080)3.67263950
40mitotic sister chromatid segregation (GO:0000070)3.66231561
41mitotic chromosome condensation (GO:0007076)3.65480812
42DNA replication-independent nucleosome organization (GO:0034724)3.53190887
43DNA replication-independent nucleosome assembly (GO:0006336)3.53190887
44translesion synthesis (GO:0019985)3.51835472
45sister chromatid segregation (GO:0000819)3.47087994
46kinetochore organization (GO:0051383)3.46032299
47metaphase plate congression (GO:0051310)3.40205231
48DNA synthesis involved in DNA repair (GO:0000731)3.39088235
49viral transcription (GO:0019083)3.38315865
50negative regulation of chromosome segregation (GO:0051985)3.35934314
51translational termination (GO:0006415)3.34604304
52L-serine metabolic process (GO:0006563)3.32626773
53chromosome condensation (GO:0030261)3.32616212
54negative regulation of mRNA processing (GO:0050686)3.31313409
55regulation of centriole replication (GO:0046599)3.31213340
56telomere maintenance (GO:0000723)3.30000876
57telomere organization (GO:0032200)3.28919374
58mismatch repair (GO:0006298)3.28521730
59viral mRNA export from host cell nucleus (GO:0046784)3.28479518
60protein complex localization (GO:0031503)3.28464378
61spindle checkpoint (GO:0031577)3.27854112
62attachment of spindle microtubules to kinetochore (GO:0008608)3.23575437
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23034339
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.23034339
65negative regulation of sister chromatid segregation (GO:0033046)3.23034339
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23034339
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23034339
68regulation of histone H3-K9 methylation (GO:0051570)3.22785757
69mitotic spindle checkpoint (GO:0071174)3.22771983
70postreplication repair (GO:0006301)3.22287185
71regulation of sister chromatid cohesion (GO:0007063)3.20008335
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19520652
73chromosome segregation (GO:0007059)3.17420584
74establishment of chromosome localization (GO:0051303)3.17379108
75ribosome biogenesis (GO:0042254)3.17101072
76pore complex assembly (GO:0046931)3.16649495
77chromatin assembly or disassembly (GO:0006333)3.14295414
78translational elongation (GO:0006414)3.13585684
79positive regulation of chromosome segregation (GO:0051984)3.12947991
80* DNA conformation change (GO:0071103)3.10465857
81negative regulation of mRNA metabolic process (GO:1903312)3.10336554
82translational initiation (GO:0006413)3.10195961
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09526168
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09526168
85mitotic spindle assembly checkpoint (GO:0007094)3.09054638
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.08678518
87meiotic chromosome segregation (GO:0045132)3.08598026
88histone exchange (GO:0043486)3.08569280
89ribonucleoprotein complex biogenesis (GO:0022613)3.07950157
90base-excision repair (GO:0006284)3.07725149
91ribosomal large subunit biogenesis (GO:0042273)3.07156951
92DNA strand renaturation (GO:0000733)3.06072262
93regulation of spindle organization (GO:0090224)3.05940485
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05830805
95chromatin assembly (GO:0031497)3.05328528
96spindle assembly checkpoint (GO:0071173)3.05215907
97ribosome assembly (GO:0042255)3.05151460
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.04662167
99mitotic sister chromatid cohesion (GO:0007064)3.03102597
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02474494
101regulation of mitotic sister chromatid segregation (GO:0033047)3.02382028
102regulation of sister chromatid segregation (GO:0033045)3.02382028
103regulation of mitotic sister chromatid separation (GO:0010965)3.02382028
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02161191
105DNA deamination (GO:0045006)3.00954957
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99415025
107negative regulation of RNA splicing (GO:0033119)2.99178492
108heterochromatin organization (GO:0070828)2.99158429
109ribosomal small subunit biogenesis (GO:0042274)2.98669361
110DNA packaging (GO:0006323)2.98632728
111establishment of integrated proviral latency (GO:0075713)2.98182628
112spliceosomal snRNP assembly (GO:0000387)2.94459823
113kinetochore assembly (GO:0051382)2.93945095
114nuclear envelope organization (GO:0006998)2.93201241
115transcription-coupled nucleotide-excision repair (GO:0006283)2.92993990
116protein localization to chromosome (GO:0034502)2.91926138
117rRNA processing (GO:0006364)2.91010373
118dosage compensation (GO:0007549)2.90730009
119regulation of helicase activity (GO:0051095)2.88770184
120* DNA replication (GO:0006260)2.87538148
121mRNA splicing, via spliceosome (GO:0000398)2.87211053
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87211053
123RNA splicing, via transesterification reactions (GO:0000375)2.86571306
124regulation of chromosome segregation (GO:0051983)2.85350681
125DNA topological change (GO:0006265)2.85275877
126negative regulation of histone methylation (GO:0031061)2.84831944
127ATP-dependent chromatin remodeling (GO:0043044)2.83321026
128regulation of centrosome cycle (GO:0046605)2.82466296
129* G1/S transition of mitotic cell cycle (GO:0000082)2.82237367
130* cell cycle G1/S phase transition (GO:0044843)2.82237367
131regulation of translational fidelity (GO:0006450)2.81993035
132rRNA metabolic process (GO:0016072)2.81712808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.31576755
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.03489190
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95170890
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62565290
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15154735
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86802244
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65809555
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55983719
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48704710
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44181727
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.42243489
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23189106
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22726078
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.19233305
15XRN2_22483619_ChIP-Seq_HELA_Human2.19091790
16AR_21909140_ChIP-Seq_LNCAP_Human2.18730893
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14226646
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11902383
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.10836567
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06696861
21MYC_22102868_ChIP-Seq_BL_Human2.03762961
22* E2F7_22180533_ChIP-Seq_HELA_Human10.6208844
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93978386
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89505724
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88236540
26* VDR_23849224_ChIP-Seq_CD4+_Human1.88014771
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81024610
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78268581
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77568772
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.77333310
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76136871
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71721989
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70075964
34CIITA_25753668_ChIP-Seq_RAJI_Human1.69121044
35DCP1A_22483619_ChIP-Seq_HELA_Human1.67325734
36TTF2_22483619_ChIP-Seq_HELA_Human1.65246227
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64664568
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63909796
39GABP_19822575_ChIP-Seq_HepG2_Human1.60858935
40* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60516043
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56848473
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52901372
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50581486
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48432855
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40822521
46KDM5A_27292631_Chip-Seq_BREAST_Human1.38641823
47ELK1_19687146_ChIP-ChIP_HELA_Human1.38387064
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37972224
49VDR_21846776_ChIP-Seq_THP-1_Human1.37807509
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36587238
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35865300
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32145907
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31914500
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30773915
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30111312
56* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29810801
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27685647
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27652031
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27315570
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.24904561
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24884330
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22414508
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19895044
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18472625
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.18233872
66TFEB_21752829_ChIP-Seq_HELA_Human1.16951829
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16018905
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15046419
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14141967
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12672895
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07175990
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02506817
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00931778
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.00138690
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97991114
76* SPI1_23547873_ChIP-Seq_NB4_Human0.97407139
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95991306
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95324880
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94549781
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93979246
81SALL1_21062744_ChIP-ChIP_HESCs_Human0.93104908
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92251471
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91951555
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91565201
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89738410
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89481014
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89369428
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.89069851
89* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87711546
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85183192
91MYC_18940864_ChIP-ChIP_HL60_Human0.85082721
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84373030
93* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84245876
94ZNF263_19887448_ChIP-Seq_K562_Human0.83456090
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.82699815
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.82524873
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82328205
98* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81364058
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80551616
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79904646
101CHD1_26751641_Chip-Seq_LNCaP_Human0.79539012
102UTX_26944678_Chip-Seq_JUKART_Human0.79019947
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77708713
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77336099
105MAF_26560356_Chip-Seq_TH1_Human0.76631973
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76144630
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.76073324
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75817925
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75808709
110SCL_19346495_ChIP-Seq_HPC-7_Human0.74613969
111MYB_26560356_Chip-Seq_TH1_Human0.74477967
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.74212410
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71707679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.84427594
2MP0003693_abnormal_embryo_hatching4.76879165
3MP0008057_abnormal_DNA_replication4.60327586
4MP0003111_abnormal_nucleus_morphology4.48702409
5MP0004957_abnormal_blastocyst_morpholog4.20670166
6MP0003077_abnormal_cell_cycle3.97502374
7MP0008058_abnormal_DNA_repair3.27210059
8MP0002396_abnormal_hematopoietic_system2.92646549
9MP0010352_gastrointestinal_tract_polyps2.87884773
10MP0008007_abnormal_cellular_replicative2.81008456
11MP0008932_abnormal_embryonic_tissue2.47554040
12MP0001730_embryonic_growth_arrest2.41080745
13MP0000350_abnormal_cell_proliferation2.35173197
14MP0010307_abnormal_tumor_latency2.17359862
15MP0003123_paternal_imprinting2.17035241
16MP0009697_abnormal_copulation2.06123053
17MP0008877_abnormal_DNA_methylation1.97804012
18MP0000490_abnormal_crypts_of1.94581564
19MP0004808_abnormal_hematopoietic_stem1.90089756
20MP0001672_abnormal_embryogenesis/_devel1.78146848
21MP0005380_embryogenesis_phenotype1.78146848
22MP0001697_abnormal_embryo_size1.74604450
23MP0003786_premature_aging1.70977871
24MP0003984_embryonic_growth_retardation1.63949638
25* MP0002080_prenatal_lethality1.61971053
26MP0003941_abnormal_skin_development1.60938358
27MP0002088_abnormal_embryonic_growth/wei1.59988022
28MP0001545_abnormal_hematopoietic_system1.56158498
29MP0005397_hematopoietic_system_phenotyp1.56158498
30* MP0002019_abnormal_tumor_incidence1.55299911
31MP0000313_abnormal_cell_death1.53744997
32* MP0002085_abnormal_embryonic_tissue1.51285176
33MP0002086_abnormal_extraembryonic_tissu1.51117414
34MP0004197_abnormal_fetal_growth/weight/1.50899069
35MP0005076_abnormal_cell_differentiation1.50652221
36MP0002084_abnormal_developmental_patter1.48123306
37MP0003763_abnormal_thymus_physiology1.37594261
38MP0002398_abnormal_bone_marrow1.36284532
39MP0003567_abnormal_fetal_cardiomyocyte1.35594009
40MP0000703_abnormal_thymus_morphology1.34236064
41MP0003121_genomic_imprinting1.29858934
42MP0009333_abnormal_splenocyte_physiolog1.28610596
43MP0002722_abnormal_immune_system1.24241647
44MP0006035_abnormal_mitochondrial_morpho1.24109405
45MP0009278_abnormal_bone_marrow1.22830504
46MP0003806_abnormal_nucleotide_metabolis1.21054977
47MP0006054_spinal_hemorrhage1.20873787
48MP0000689_abnormal_spleen_morphology1.18967109
49MP0004185_abnormal_adipocyte_glucose1.12769405
50MP0001293_anophthalmia1.12159233
51MP0001346_abnormal_lacrimal_gland1.11854572
52MP0003890_abnormal_embryonic-extraembry1.11459652
53MP0003937_abnormal_limbs/digits/tail_de1.11108088
54MP0002697_abnormal_eye_size1.09881507
55* MP0002429_abnormal_blood_cell1.03379162
56MP0010030_abnormal_orbit_morphology1.02132636
57MP0001661_extended_life_span1.01432175
58MP0002210_abnormal_sex_determination1.00353950
59MP0002009_preneoplasia0.99915775
60MP0000858_altered_metastatic_potential0.96908054
61MP0001915_intracranial_hemorrhage0.94794015
62MP0003566_abnormal_cell_adhesion0.93873728
63MP0004233_abnormal_muscle_weight0.93463442
64MP0003705_abnormal_hypodermis_morpholog0.92689978
65MP0001145_abnormal_male_reproductive0.92023408
66MP0000537_abnormal_urethra_morphology0.90743857
67MP0000716_abnormal_immune_system0.90531281
68MP0005501_abnormal_skin_physiology0.88424014
69MP0005023_abnormal_wound_healing0.87692286
70MP0001286_abnormal_eye_development0.86690497
71MP0010234_abnormal_vibrissa_follicle0.85992102
72MP0002938_white_spotting0.84888822
73MP0009053_abnormal_anal_canal0.84501026
74MP0009672_abnormal_birth_weight0.83511633
75MP0005384_cellular_phenotype0.81515720
76MP0001800_abnormal_humoral_immune0.80922033
77MP0005621_abnormal_cell_physiology0.79759609
78MP0000358_abnormal_cell_content/0.79003998
79MP0001835_abnormal_antigen_presentation0.78700303
80MP0003718_maternal_effect0.78330205
81MP0004133_heterotaxia0.76758021
82MP0006036_abnormal_mitochondrial_physio0.76719207
83MP0000477_abnormal_intestine_morphology0.75766129
84MP0003699_abnormal_female_reproductive0.74937353
85MP0000428_abnormal_craniofacial_morphol0.74567637
86MP0002111_abnormal_tail_morphology0.74125107
87MP0002420_abnormal_adaptive_immunity0.73917061
88MP0001929_abnormal_gametogenesis0.73767452
89MP0000685_abnormal_immune_system0.73449683
90MP0000653_abnormal_sex_gland0.73331918
91MP0003221_abnormal_cardiomyocyte_apopto0.72766171
92MP0003119_abnormal_digestive_system0.72524063
93MP0001819_abnormal_immune_cell0.72136167
94MP0000566_synostosis0.71692266
95MP0001853_heart_inflammation0.71686648
96MP0000465_gastrointestinal_hemorrhage0.71357173
97MP0003943_abnormal_hepatobiliary_system0.71205862
98MP0002452_abnormal_antigen_presenting0.69915153
99MP0002405_respiratory_system_inflammati0.68865260
100MP0009703_decreased_birth_body0.68816577
101MP0003315_abnormal_perineum_morphology0.68616161
102MP0002075_abnormal_coat/hair_pigmentati0.68564579
103MP0005408_hypopigmentation0.66806162
104MP0000372_irregular_coat_pigmentation0.66520002
105MP0001119_abnormal_female_reproductive0.66176008
106MP0002796_impaired_skin_barrier0.65890423
107MP0001849_ear_inflammation0.65699048
108MP0004264_abnormal_extraembryonic_tissu0.64521543
109MP0005174_abnormal_tail_pigmentation0.64345887
110MP0008995_early_reproductive_senescence0.63201470
111MP0002092_abnormal_eye_morphology0.63052688
112MP0005075_abnormal_melanosome_morpholog0.62379005
113MP0002095_abnormal_skin_pigmentation0.61950932
114MP0002161_abnormal_fertility/fecundity0.61608136
115MP0003861_abnormal_nervous_system0.60110890
116MP0002877_abnormal_melanocyte_morpholog0.60054661
117MP0010155_abnormal_intestine_physiology0.59792506
118MP0003186_abnormal_redox_activity0.59756773
119MP0002006_tumorigenesis0.59591300
120MP0002166_altered_tumor_susceptibility0.58253938
121MP0001881_abnormal_mammary_gland0.58199914
122MP0003448_altered_tumor_morphology0.58198069
123MP0002233_abnormal_nose_morphology0.58192067
124MP0006292_abnormal_olfactory_placode0.58004222
125MP0002160_abnormal_reproductive_system0.57622576
126MP0002723_abnormal_immune_serum0.56965296
127MP0008770_decreased_survivor_rate0.56842887
128MP0003698_abnormal_male_reproductive0.54395333
129MP0005395_other_phenotype0.52134641
130MP0000579_abnormal_nail_morphology0.50365900
131MP0003115_abnormal_respiratory_system0.48100049

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.85636107
2Reticulocytopenia (HP:0001896)4.16193402
3Chromsome breakage (HP:0040012)4.06327464
4Ependymoma (HP:0002888)3.94633997
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.80018589
6Colon cancer (HP:0003003)3.79837980
7Medulloblastoma (HP:0002885)3.73376963
8Abnormality of cells of the erythroid lineage (HP:0012130)3.54019292
9Selective tooth agenesis (HP:0001592)3.45075635
10Agnosia (HP:0010524)3.44153626
11Abnormal number of erythroid precursors (HP:0012131)3.41072631
12Breast hypoplasia (HP:0003187)3.40345939
13Abnormality of chromosome stability (HP:0003220)3.27448567
14Nephroblastoma (Wilms tumor) (HP:0002667)3.19493367
15Microvesicular hepatic steatosis (HP:0001414)3.18822288
16Patellar aplasia (HP:0006443)3.09605270
17Oral leukoplakia (HP:0002745)3.07063857
18Meckel diverticulum (HP:0002245)2.96665285
19Embryonal renal neoplasm (HP:0011794)2.94523159
20Aplastic anemia (HP:0001915)2.94404933
21Abnormality of the preputium (HP:0100587)2.90339951
22Abnormality of the anterior horn cell (HP:0006802)2.87189425
23Degeneration of anterior horn cells (HP:0002398)2.87189425
24Abnormality of the ileum (HP:0001549)2.86797605
25Basal cell carcinoma (HP:0002671)2.86163584
26Rhabdomyosarcoma (HP:0002859)2.85713340
27Myelodysplasia (HP:0002863)2.85498872
28Aplasia/Hypoplasia of the patella (HP:0006498)2.85278806
2911 pairs of ribs (HP:0000878)2.81933466
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.77020929
31Absent thumb (HP:0009777)2.72948613
32Abnormality of cochlea (HP:0000375)2.65910705
33Abnormal number of incisors (HP:0011064)2.61181185
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.60214683
35Abnormality of glycolysis (HP:0004366)2.57857754
36Thrombocytosis (HP:0001894)2.54302663
37Proximal placement of thumb (HP:0009623)2.50457765
38Astrocytoma (HP:0009592)2.49744617
39Abnormality of the astrocytes (HP:0100707)2.49744617
40Increased nuchal translucency (HP:0010880)2.48929258
41Duodenal stenosis (HP:0100867)2.48492758
42Small intestinal stenosis (HP:0012848)2.48492758
43Amaurosis fugax (HP:0100576)2.47797505
44Neoplasm of the pancreas (HP:0002894)2.46422364
45Deviation of the thumb (HP:0009603)2.46283002
46Progressive muscle weakness (HP:0003323)2.45653618
47Impulsivity (HP:0100710)2.44070967
48Bone marrow hypocellularity (HP:0005528)2.42395223
49Carpal bone hypoplasia (HP:0001498)2.42239561
50Ectopic kidney (HP:0000086)2.38770975
51Pallor (HP:0000980)2.34847318
52Absent radius (HP:0003974)2.34670832
53High pitched voice (HP:0001620)2.32221742
54Glioma (HP:0009733)2.28895148
55Premature graying of hair (HP:0002216)2.27995749
56Macrocytic anemia (HP:0001972)2.26713072
57Progressive external ophthalmoplegia (HP:0000590)2.25956103
58Neoplasm of striated muscle (HP:0009728)2.24246926
59Increased serum pyruvate (HP:0003542)2.23671541
60Rough bone trabeculation (HP:0100670)2.23584074
61Neoplasm of the oral cavity (HP:0100649)2.23372500
62Missing ribs (HP:0000921)2.22762622
63Atresia of the external auditory canal (HP:0000413)2.22510162
64Choanal atresia (HP:0000453)2.21692443
65Sloping forehead (HP:0000340)2.21624168
66IgM deficiency (HP:0002850)2.21352288
67Cortical dysplasia (HP:0002539)2.20202261
68Tracheoesophageal fistula (HP:0002575)2.19463669
69Volvulus (HP:0002580)2.18739584
70Lymphoma (HP:0002665)2.18391961
71Absent forearm bone (HP:0003953)2.17732971
72Aplasia involving forearm bones (HP:0009822)2.17732971
73Abnormality of the carotid arteries (HP:0005344)2.17386732
74Facial cleft (HP:0002006)2.15927561
75Short 4th metacarpal (HP:0010044)2.15554206
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15554206
77Abnormality of the labia minora (HP:0012880)2.13531689
78Squamous cell carcinoma (HP:0002860)2.13034654
79Cafe-au-lait spot (HP:0000957)2.12972623
80Duplication of thumb phalanx (HP:0009942)2.12428001
81Slender long bone (HP:0003100)2.09866949
82Duplicated collecting system (HP:0000081)2.09440775
83Abnormality of the duodenum (HP:0002246)2.06200912
84High anterior hairline (HP:0009890)2.06090176
85Abnormal lung lobation (HP:0002101)2.05497360
86Prominent nose (HP:0000448)2.04080348
87Asplenia (HP:0001746)2.02811280
88Microretrognathia (HP:0000308)2.02316897
89Spastic diplegia (HP:0001264)2.00637795
90Embryonal neoplasm (HP:0002898)1.99543650
91Premature ovarian failure (HP:0008209)1.98702517
92Cellular immunodeficiency (HP:0005374)1.98499261
93Neoplasm of the colon (HP:0100273)1.96129450
94Cholecystitis (HP:0001082)1.94002788
95Abnormal gallbladder physiology (HP:0012438)1.94002788
96Abnormality of reticulocytes (HP:0004312)1.93401516
97Abnormality of DNA repair (HP:0003254)1.93093982
98Arteriovenous malformation (HP:0100026)1.92433133
99Abnormality of pyrimidine metabolism (HP:0004353)1.92105469
100Pancytopenia (HP:0001876)1.90995945
101Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90942781
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.90762307
103Horseshoe kidney (HP:0000085)1.90367779
104Trismus (HP:0000211)1.89774468
105Supernumerary spleens (HP:0009799)1.88684261
106Biliary tract neoplasm (HP:0100574)1.88254066
107Short thumb (HP:0009778)1.88091627
108Abnormality of the calcaneus (HP:0008364)1.85737208
109Clubbing of toes (HP:0100760)1.84376890
110Secondary amenorrhea (HP:0000869)1.83928225
111Morphological abnormality of the inner ear (HP:0011390)1.83107686
112Triphalangeal thumb (HP:0001199)1.82243918
113Absent epiphyses (HP:0010577)1.81946204
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81946204
115Overlapping toe (HP:0001845)1.81710554
116Cerebral hypomyelination (HP:0006808)1.81241067
117Abnormality of the renal collecting system (HP:0004742)1.80227736
118Multiple enchondromatosis (HP:0005701)1.79035605
119Ragged-red muscle fibers (HP:0003200)1.78628332
120Ovarian neoplasm (HP:0100615)1.77506805
121Overriding aorta (HP:0002623)1.76809228
122Angiofibromas (HP:0010615)1.76329574
123Adenoma sebaceum (HP:0009720)1.76329574
124Poikiloderma (HP:0001029)1.76045470
125Cutaneous melanoma (HP:0012056)1.75640795
126Hyperacusis (HP:0010780)1.75540440
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.74886463
128Facial hemangioma (HP:0000329)1.74720400
129Acute lymphatic leukemia (HP:0006721)1.74312489
130Irregular epiphyses (HP:0010582)1.69041714
131Deep philtrum (HP:0002002)1.66243846
132Insomnia (HP:0100785)1.65835489
133Cleft eyelid (HP:0000625)1.65309526
134Pancreatic islet-cell hyperplasia (HP:0004510)1.64280593
135Abnormality of the umbilical cord (HP:0010881)1.63805537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.24150061
2WEE14.10252201
3BUB13.41241106
4VRK23.10963531
5NEK22.81975162
6SMG12.68285111
7PBK2.46017914
8EEF2K2.44046993
9TSSK62.43075478
10NEK12.32627566
11PASK2.32227375
12EIF2AK12.32124098
13CDK122.24225555
14TTK2.23541948
15BRSK22.11865222
16SRPK12.06257995
17ACVR1B2.05834459
18CDK71.92243032
19RPS6KB21.88866528
20* ATR1.84808584
21PLK11.84268687
22TAF11.84094231
23MKNK11.77027362
24MAP3K101.74244764
25STK101.64157429
26CDK41.63889942
27TESK21.62013908
28AURKB1.61758975
29NME21.60241999
30TGFBR11.56994430
31SCYL21.55233892
32VRK11.54823075
33MAP3K81.48929347
34MAP4K11.47340412
35PLK41.43323726
36TLK11.41967848
37RPS6KA41.40843497
38PKN21.38698180
39CHEK21.38346510
40EIF2AK31.38223602
41BRSK11.36125884
42PLK31.35927346
43CHEK11.32063426
44DYRK31.24928152
45PAK41.23936688
46STK41.22607691
47FLT31.17389478
48NME11.10870619
49AURKA1.09678533
50MKNK21.08189149
51PIM11.04541826
52BRD41.00990866
53MST41.00105584
54STK160.97451639
55CLK10.96253696
56CCNB10.95495927
57LRRK20.93167005
58* ATM0.92833998
59* CDK20.91521671
60NUAK10.90279515
61ALK0.89566978
62CDK60.87718841
63EPHA20.86190134
64ICK0.86067207
65MAP2K30.85679251
66BTK0.83306023
67CDK80.78614419
68ZAK0.71341201
69MST1R0.69847333
70CSNK2A20.67948726
71PDK20.64609448
72* CDK10.62619194
73GRK60.62199028
74KDR0.61929574
75BRAF0.61366738
76PIM20.60218225
77CSNK2A10.59552949
78PNCK0.59441090
79MELK0.58425933
80TRIM280.58411359
81CSF1R0.56175057
82JAK30.55337903
83CDK90.55018732
84PAK10.54944573
85STK30.54296168
86TESK10.51330745
87KIT0.48443055
88MTOR0.48395353
89ZAP700.47234370
90ERBB40.45940762
91TEC0.45907338
92FGFR10.45575030
93MAPKAPK30.44121728
94RPS6KA50.41520851
95MAP3K110.41119725
96TRIB30.40997874
97PRKDC0.39242028
98AKT20.38001058
99MAPKAPK50.36729374
100CDK11A0.36717299
101CSNK1G10.35864122
102IRAK30.35405320
103CDK150.34398959
104PAK20.34036618
105CSNK1G30.33892666
106CDK180.33851298
107PRKCI0.33525861
108MAPK110.32892028
109RPS6KA60.32398658
110EIF2AK20.32241047
111RPS6KL10.31593030
112RPS6KC10.31593030
113CSNK1D0.30821420
114MAPK140.29966238
115CSNK1E0.28336487
116LATS10.28020637
117TTN0.27669632
118CDK140.27332611
119CDK30.27207253
120MET0.26430403
121BLK0.26197081
122TYK20.25843147
123ILK0.25731534
124RPS6KB10.25561573
125AKT10.25296351
126GSK3B0.24691353
127RAF10.24605552
128CAMK1G0.24480859
129CSNK1A1L0.24469964
130LYN0.24429663
131FGFR40.24119504
132TAOK20.24100946
133BCKDK0.23184819
134CAMK1D0.21847055

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.79270232
2Mismatch repair_Homo sapiens_hsa034304.92701190
3Base excision repair_Homo sapiens_hsa034103.40495618
4Homologous recombination_Homo sapiens_hsa034403.20182059
5Spliceosome_Homo sapiens_hsa030403.20158836
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19286555
7One carbon pool by folate_Homo sapiens_hsa006703.03635577
8Nucleotide excision repair_Homo sapiens_hsa034203.00821066
9RNA transport_Homo sapiens_hsa030132.94553065
10Ribosome_Homo sapiens_hsa030102.85279259
11* Cell cycle_Homo sapiens_hsa041102.84643095
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49442800
13RNA polymerase_Homo sapiens_hsa030202.44095581
14Proteasome_Homo sapiens_hsa030502.35255050
15Fanconi anemia pathway_Homo sapiens_hsa034602.27366038
16Non-homologous end-joining_Homo sapiens_hsa034502.26195633
17Pyrimidine metabolism_Homo sapiens_hsa002402.23504144
18RNA degradation_Homo sapiens_hsa030181.75432506
19mRNA surveillance pathway_Homo sapiens_hsa030151.72261364
20p53 signaling pathway_Homo sapiens_hsa041151.58175364
21Basal transcription factors_Homo sapiens_hsa030221.45983427
22Systemic lupus erythematosus_Homo sapiens_hsa053221.22625038
23Pyruvate metabolism_Homo sapiens_hsa006201.16839523
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15173702
25Epstein-Barr virus infection_Homo sapiens_hsa051691.13289257
26Antigen processing and presentation_Homo sapiens_hsa046121.11418641
27Viral carcinogenesis_Homo sapiens_hsa052031.10231761
28Purine metabolism_Homo sapiens_hsa002301.09429808
29Vitamin B6 metabolism_Homo sapiens_hsa007501.08947267
30Herpes simplex infection_Homo sapiens_hsa051681.06058066
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94571085
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89504679
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88982754
34Biosynthesis of amino acids_Homo sapiens_hsa012300.87737953
35Fatty acid elongation_Homo sapiens_hsa000620.87447365
36HTLV-I infection_Homo sapiens_hsa051660.87442992
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.84710559
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83504041
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81550061
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80936848
41Pentose phosphate pathway_Homo sapiens_hsa000300.80740363
42Oocyte meiosis_Homo sapiens_hsa041140.80723858
43Primary immunodeficiency_Homo sapiens_hsa053400.80216660
44Selenocompound metabolism_Homo sapiens_hsa004500.77675267
45MicroRNAs in cancer_Homo sapiens_hsa052060.75683060
46Small cell lung cancer_Homo sapiens_hsa052220.73955880
47Legionellosis_Homo sapiens_hsa051340.73821295
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.72008317
49Thyroid cancer_Homo sapiens_hsa052160.71113108
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67393940
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64476254
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.63805383
53Propanoate metabolism_Homo sapiens_hsa006400.62698662
54Steroid biosynthesis_Homo sapiens_hsa001000.62186893
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59193176
56Measles_Homo sapiens_hsa051620.57387867
57Chronic myeloid leukemia_Homo sapiens_hsa052200.57229997
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56625073
59Apoptosis_Homo sapiens_hsa042100.56357189
60Folate biosynthesis_Homo sapiens_hsa007900.53533086
61Hepatitis B_Homo sapiens_hsa051610.52401188
62Huntingtons disease_Homo sapiens_hsa050160.49370760
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.47778645
64Colorectal cancer_Homo sapiens_hsa052100.47434886
65Notch signaling pathway_Homo sapiens_hsa043300.46338226
66Shigellosis_Homo sapiens_hsa051310.45279235
67N-Glycan biosynthesis_Homo sapiens_hsa005100.44608541
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44526746
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43788486
70Carbon metabolism_Homo sapiens_hsa012000.43153502
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42438248
72Parkinsons disease_Homo sapiens_hsa050120.42019788
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40376627
74Viral myocarditis_Homo sapiens_hsa054160.39888463
75Alcoholism_Homo sapiens_hsa050340.39519183
76Fatty acid metabolism_Homo sapiens_hsa012120.37967611
77Sulfur relay system_Homo sapiens_hsa041220.37522701
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.36879407
79Bladder cancer_Homo sapiens_hsa052190.36632968
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36262673
81Acute myeloid leukemia_Homo sapiens_hsa052210.36221791
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35787797
83Hematopoietic cell lineage_Homo sapiens_hsa046400.34972692
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34911835
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34564064
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34444680
87TGF-beta signaling pathway_Homo sapiens_hsa043500.34269072
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34078764
89Non-small cell lung cancer_Homo sapiens_hsa052230.33394068
90Influenza A_Homo sapiens_hsa051640.33342746
91Glutathione metabolism_Homo sapiens_hsa004800.32771698
92Metabolic pathways_Homo sapiens_hsa011000.32695611
93Basal cell carcinoma_Homo sapiens_hsa052170.32338888
94HIF-1 signaling pathway_Homo sapiens_hsa040660.31622325
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30761171
96B cell receptor signaling pathway_Homo sapiens_hsa046620.29920317
97Hippo signaling pathway_Homo sapiens_hsa043900.29329148
98Leishmaniasis_Homo sapiens_hsa051400.29051667
99Pathways in cancer_Homo sapiens_hsa052000.28541866
100Lysine degradation_Homo sapiens_hsa003100.28470765
101Arginine and proline metabolism_Homo sapiens_hsa003300.27191365
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26684208
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24793212
104Galactose metabolism_Homo sapiens_hsa000520.24642874
105Arginine biosynthesis_Homo sapiens_hsa002200.23924614
106Wnt signaling pathway_Homo sapiens_hsa043100.23408998
107Pancreatic cancer_Homo sapiens_hsa052120.22681598
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22085658
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21546901
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.19863148
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.19360640
112mTOR signaling pathway_Homo sapiens_hsa041500.19281973
113Adherens junction_Homo sapiens_hsa045200.18416885
114Prostate cancer_Homo sapiens_hsa052150.18058016
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17980073
116Fructose and mannose metabolism_Homo sapiens_hsa000510.17567579
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17161229
118Renin-angiotensin system_Homo sapiens_hsa046140.17076390
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16034715
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.14919018
121Protein export_Homo sapiens_hsa030600.14855813
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12374783
123Oxidative phosphorylation_Homo sapiens_hsa001900.09339239
124Vitamin digestion and absorption_Homo sapiens_hsa049770.07398312
125Melanoma_Homo sapiens_hsa052180.06347564

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