MCM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA unwinding involved in DNA replication (GO:0006268)5.62970290
2* DNA strand elongation involved in DNA replication (GO:0006271)5.44582533
3* DNA replication initiation (GO:0006270)5.21441567
4* DNA strand elongation (GO:0022616)5.17586850
5telomere maintenance via semi-conservative replication (GO:0032201)4.98414538
6protein localization to kinetochore (GO:0034501)4.74172200
7DNA replication checkpoint (GO:0000076)4.59546596
8DNA replication-dependent nucleosome assembly (GO:0006335)4.49343137
9DNA replication-dependent nucleosome organization (GO:0034723)4.49343137
10telomere maintenance via recombination (GO:0000722)4.40175005
11folic acid-containing compound biosynthetic process (GO:0009396)4.39872182
12IMP biosynthetic process (GO:0006188)4.32368130
13nucleobase biosynthetic process (GO:0046112)4.30626565
14mitotic recombination (GO:0006312)4.25428181
15nuclear pore organization (GO:0006999)4.24255486
16mitotic nuclear envelope disassembly (GO:0007077)4.17968030
17formation of translation preinitiation complex (GO:0001731)4.10801318
18DNA topological change (GO:0006265)4.10311779
19telomere maintenance via telomere lengthening (GO:0010833)3.99364144
20protein localization to chromosome, centromeric region (GO:0071459)3.98746017
21nuclear pore complex assembly (GO:0051292)3.98503403
22nucleotide-excision repair, DNA gap filling (GO:0006297)3.90198130
23membrane disassembly (GO:0030397)3.87367968
24nuclear envelope disassembly (GO:0051081)3.87367968
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87115997
26mitotic metaphase plate congression (GO:0007080)3.82815367
27IMP metabolic process (GO:0046040)3.81353027
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.81106049
29* DNA duplex unwinding (GO:0032508)3.79649835
30* DNA geometric change (GO:0032392)3.77790225
31maturation of SSU-rRNA (GO:0030490)3.73691125
32purine nucleobase biosynthetic process (GO:0009113)3.71952669
33mitotic chromosome condensation (GO:0007076)3.70389466
34mitotic sister chromatid segregation (GO:0000070)3.69344099
35chromosome condensation (GO:0030261)3.67504588
36ribosomal small subunit assembly (GO:0000028)3.59447500
37chromatin remodeling at centromere (GO:0031055)3.58009892
38peptidyl-arginine omega-N-methylation (GO:0035247)3.57834119
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57427374
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.57427374
41viral mRNA export from host cell nucleus (GO:0046784)3.57319499
42DNA synthesis involved in DNA repair (GO:0000731)3.56554290
43ribosomal small subunit biogenesis (GO:0042274)3.55993311
44CENP-A containing nucleosome assembly (GO:0034080)3.52014715
45sister chromatid segregation (GO:0000819)3.47650722
46DNA replication-independent nucleosome assembly (GO:0006336)3.46646226
47DNA replication-independent nucleosome organization (GO:0034724)3.46646226
48non-recombinational repair (GO:0000726)3.46283942
49double-strand break repair via nonhomologous end joining (GO:0006303)3.46283942
50translesion synthesis (GO:0019985)3.43645215
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43159490
52DNA ligation (GO:0006266)3.42801825
53metaphase plate congression (GO:0051310)3.42467688
54establishment of viral latency (GO:0019043)3.41870364
55protein complex localization (GO:0031503)3.41728703
56negative regulation of mRNA metabolic process (GO:1903312)3.40972434
57regulation of sister chromatid cohesion (GO:0007063)3.40402885
58regulation of histone H3-K9 methylation (GO:0051570)3.39512936
59heterochromatin organization (GO:0070828)3.33573214
60viral transcription (GO:0019083)3.31586595
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29759531
62proline biosynthetic process (GO:0006561)3.29300686
63kinetochore organization (GO:0051383)3.28892875
64translational termination (GO:0006415)3.28584512
65ribosome assembly (GO:0042255)3.28033424
66ribosome biogenesis (GO:0042254)3.26560725
67chromatin assembly or disassembly (GO:0006333)3.24555956
68positive regulation of chromosome segregation (GO:0051984)3.24337624
69mismatch repair (GO:0006298)3.20600996
70attachment of spindle microtubules to kinetochore (GO:0008608)3.20235328
71postreplication repair (GO:0006301)3.18698376
72negative regulation of RNA splicing (GO:0033119)3.18509015
73DNA packaging (GO:0006323)3.18310319
74folic acid metabolic process (GO:0046655)3.15909974
75telomere maintenance (GO:0000723)3.14223468
76telomere organization (GO:0032200)3.13488578
77translational initiation (GO:0006413)3.12444071
78regulation of spindle organization (GO:0090224)3.12290550
79histone arginine methylation (GO:0034969)3.12031595
80regulation of gene silencing by RNA (GO:0060966)3.11285195
81regulation of posttranscriptional gene silencing (GO:0060147)3.11285195
82regulation of gene silencing by miRNA (GO:0060964)3.11285195
83establishment of integrated proviral latency (GO:0075713)3.10765851
84* DNA conformation change (GO:0071103)3.10495762
85establishment of chromosome localization (GO:0051303)3.09935611
86ribonucleoprotein complex biogenesis (GO:0022613)3.09908219
87translational elongation (GO:0006414)3.09378455
88regulation of helicase activity (GO:0051095)3.09125946
89nucleobase-containing small molecule interconversion (GO:0015949)3.07964836
90pore complex assembly (GO:0046931)3.07497942
91ribosomal large subunit biogenesis (GO:0042273)3.07105099
92base-excision repair (GO:0006284)3.07078163
93DNA deamination (GO:0045006)3.06491437
94negative regulation of histone methylation (GO:0031061)3.06484379
95regulation of translational fidelity (GO:0006450)3.06462965
96regulation of nuclear cell cycle DNA replication (GO:0033262)3.06174760
97cellular protein complex localization (GO:0034629)3.05103359
98protein-DNA complex disassembly (GO:0032986)3.04660321
99nucleosome disassembly (GO:0006337)3.04660321
100histone exchange (GO:0043486)3.03633060
101chromatin assembly (GO:0031497)3.03203351
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.02678616
103L-serine metabolic process (GO:0006563)3.01229581
104nuclear envelope organization (GO:0006998)3.01228138
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00642379
106ATP-dependent chromatin remodeling (GO:0043044)3.00291467
107negative regulation of mRNA processing (GO:0050686)2.99305109
108spliceosomal snRNP assembly (GO:0000387)2.99135368
109V(D)J recombination (GO:0033151)2.98568641
110dosage compensation (GO:0007549)2.97859188
111rRNA transcription (GO:0009303)2.97716956
112chromosome segregation (GO:0007059)2.97297351
113protein localization to chromosome (GO:0034502)2.96940442
114regulation of chromosome segregation (GO:0051983)2.96896232
115regulation of centrosome cycle (GO:0046605)2.96325064
116negative regulation of chromosome segregation (GO:0051985)2.96042066
117meiotic chromosome segregation (GO:0045132)2.95157585
118regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94991359
119regulation of translational termination (GO:0006449)2.94736230
120mRNA splicing, via spliceosome (GO:0000398)2.94283731
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94283731
122RNA splicing, via transesterification reactions (GO:0000375)2.93870004
123termination of RNA polymerase II transcription (GO:0006369)2.92867063
124peptidyl-arginine N-methylation (GO:0035246)2.92651172
125peptidyl-arginine methylation (GO:0018216)2.92651172
126mitotic sister chromatid cohesion (GO:0007064)2.92204421
127rRNA processing (GO:0006364)2.90830010
128kinetochore assembly (GO:0051382)2.88797080
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88591719
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88591719
131negative regulation of sister chromatid segregation (GO:0033046)2.88591719
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.88591719
133transcription-coupled nucleotide-excision repair (GO:0006283)2.88251977
134* DNA replication (GO:0006260)2.85118374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.39092489
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.07510714
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88856991
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66359147
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15963809
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95852151
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69845255
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58751229
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.38698345
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32204725
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.30195930
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.27294200
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27097787
14XRN2_22483619_ChIP-Seq_HELA_Human2.21323041
15AR_21909140_ChIP-Seq_LNCAP_Human2.17605241
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.16666958
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12178836
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10863190
19MYC_22102868_ChIP-Seq_BL_Human2.09583673
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.06147702
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05201030
22E2F7_22180533_ChIP-Seq_HELA_Human10.4946302
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97822046
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93280975
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91818492
26VDR_23849224_ChIP-Seq_CD4+_Human1.85206290
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83590100
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81756575
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78044427
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74756046
31FOXP3_21729870_ChIP-Seq_TREG_Human1.74260656
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73785676
33CIITA_25753668_ChIP-Seq_RAJI_Human1.70807159
34DCP1A_22483619_ChIP-Seq_HELA_Human1.65422426
35TTF2_22483619_ChIP-Seq_HELA_Human1.65040836
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62607819
37* GABP_19822575_ChIP-Seq_HepG2_Human1.61867614
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58503123
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57486931
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56416154
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54980242
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54675654
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53582809
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52649342
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49014723
46ZNF263_19887448_ChIP-Seq_K562_Human1.44889938
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43664420
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.40053425
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36875432
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33191294
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32038733
52VDR_21846776_ChIP-Seq_THP-1_Human1.31436223
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.29396640
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29333487
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.28518157
56ELK1_19687146_ChIP-ChIP_HELA_Human1.26085672
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25994680
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25332086
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24780278
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24526294
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24372854
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23454574
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23186473
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23063465
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18743776
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16502985
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14782129
68* TFEB_21752829_ChIP-Seq_HELA_Human1.12771499
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12489187
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08940174
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08576513
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07441335
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06032833
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05019555
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04720347
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04288412
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00958128
78ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99317897
79PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99204367
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98604834
81TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98133149
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96946470
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96946470
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96946470
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96515569
86* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96093166
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95938316
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94792321
89NANOG_21062744_ChIP-ChIP_HESCs_Human0.93757031
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92709266
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91936806
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.91273635
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89834292
94CHD1_26751641_Chip-Seq_LNCaP_Human0.88125404
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87036476
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85664537
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85456589
98MYC_18940864_ChIP-ChIP_HL60_Human0.84548468
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84294657
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83610302
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82014217
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81762394
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.81758949
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.80631129
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80306740
106SPI1_23547873_ChIP-Seq_NB4_Human0.80208988
107* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78093419
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77651807
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77595745
110NCOR1_26117541_ChIP-Seq_K562_Human0.77219770
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77038393
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77029007
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76941456
114TET1_21451524_ChIP-Seq_MESCs_Mouse0.76363471
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76172056
116* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75632025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.86616876
2MP0003693_abnormal_embryo_hatching4.85096368
3* MP0003111_abnormal_nucleus_morphology4.50229522
4MP0004957_abnormal_blastocyst_morpholog4.31395884
5MP0008057_abnormal_DNA_replication4.23861829
6* MP0003077_abnormal_cell_cycle3.95327407
7MP0008058_abnormal_DNA_repair3.14999377
8MP0008007_abnormal_cellular_replicative2.75094095
9MP0008932_abnormal_embryonic_tissue2.58867235
10MP0001730_embryonic_growth_arrest2.57612929
11MP0002396_abnormal_hematopoietic_system2.50350683
12MP0003123_paternal_imprinting2.43378169
13* MP0000350_abnormal_cell_proliferation2.38869347
14MP0008877_abnormal_DNA_methylation2.24325610
15MP0010307_abnormal_tumor_latency2.23926665
16MP0001672_abnormal_embryogenesis/_devel1.91210854
17MP0005380_embryogenesis_phenotype1.91210854
18MP0001697_abnormal_embryo_size1.88095408
19* MP0010352_gastrointestinal_tract_polyps1.75389510
20MP0004185_abnormal_adipocyte_glucose1.73789883
21* MP0002080_prenatal_lethality1.72782745
22MP0003984_embryonic_growth_retardation1.72620768
23* MP0002085_abnormal_embryonic_tissue1.72371200
24MP0003786_premature_aging1.72059450
25MP0002084_abnormal_developmental_patter1.70412576
26MP0002088_abnormal_embryonic_growth/wei1.68933919
27MP0004808_abnormal_hematopoietic_stem1.68163753
28MP0001346_abnormal_lacrimal_gland1.67785715
29MP0005076_abnormal_cell_differentiation1.66626939
30MP0004197_abnormal_fetal_growth/weight/1.65908178
31* MP0000490_abnormal_crypts_of1.62984936
32MP0002009_preneoplasia1.62436218
33MP0002086_abnormal_extraembryonic_tissu1.59824028
34MP0010030_abnormal_orbit_morphology1.53746654
35MP0000313_abnormal_cell_death1.53691112
36MP0009697_abnormal_copulation1.52677916
37MP0010234_abnormal_vibrissa_follicle1.51640252
38* MP0002019_abnormal_tumor_incidence1.50474466
39MP0003121_genomic_imprinting1.50186299
40MP0004233_abnormal_muscle_weight1.49658478
41MP0005451_abnormal_body_composition1.39055018
42MP0000537_abnormal_urethra_morphology1.38141893
43MP0003567_abnormal_fetal_cardiomyocyte1.37417388
44MP0001293_anophthalmia1.35583184
45MP0005397_hematopoietic_system_phenotyp1.33027994
46MP0001545_abnormal_hematopoietic_system1.33027994
47MP0003890_abnormal_embryonic-extraembry1.32688811
48MP0000703_abnormal_thymus_morphology1.25959574
49MP0009278_abnormal_bone_marrow1.19984865
50MP0009333_abnormal_splenocyte_physiolog1.18098627
51MP0003705_abnormal_hypodermis_morpholog1.17763590
52MP0002210_abnormal_sex_determination1.15470870
53MP0000566_synostosis1.15193049
54MP0003763_abnormal_thymus_physiology1.13949891
55MP0003806_abnormal_nucleotide_metabolis1.09556608
56* MP0002398_abnormal_bone_marrow1.09290406
57MP0001661_extended_life_span1.08655712
58MP0003119_abnormal_digestive_system1.07301562
59MP0005623_abnormal_meninges_morphology1.05125644
60MP0001145_abnormal_male_reproductive1.05053959
61* MP0002722_abnormal_immune_system1.04704626
62MP0003718_maternal_effect1.02793820
63MP0002653_abnormal_ependyma_morphology1.02176679
64MP0009053_abnormal_anal_canal0.99923817
65MP0006054_spinal_hemorrhage0.98827669
66MP0006035_abnormal_mitochondrial_morpho0.97458567
67MP0009672_abnormal_birth_weight0.96995805
68MP0004133_heterotaxia0.96603501
69* MP0000689_abnormal_spleen_morphology0.95999335
70MP0001915_intracranial_hemorrhage0.91505068
71MP0003315_abnormal_perineum_morphology0.89664125
72MP0002163_abnormal_gland_morphology0.89272159
73MP0002111_abnormal_tail_morphology0.88999485
74MP0005023_abnormal_wound_healing0.87891874
75MP0001929_abnormal_gametogenesis0.87184632
76MP0000653_abnormal_sex_gland0.85819277
77MP0006292_abnormal_olfactory_placode0.84491549
78* MP0002429_abnormal_blood_cell0.83648151
79MP0005384_cellular_phenotype0.83129750
80MP0003566_abnormal_cell_adhesion0.82050701
81MP0000858_altered_metastatic_potential0.81882442
82MP0001849_ear_inflammation0.81558893
83MP0002249_abnormal_larynx_morphology0.81515842
84MP0005621_abnormal_cell_physiology0.80851001
85MP0009703_decreased_birth_body0.80653947
86MP0000358_abnormal_cell_content/0.79967153
87MP0002092_abnormal_eye_morphology0.79828074
88MP0002796_impaired_skin_barrier0.78335039
89MP0005220_abnormal_exocrine_pancreas0.77724068
90MP0000428_abnormal_craniofacial_morphol0.76567804
91MP0003937_abnormal_limbs/digits/tail_de0.75470095
92MP0001727_abnormal_embryo_implantation0.73460335
93MP0002160_abnormal_reproductive_system0.73118765
94MP0001119_abnormal_female_reproductive0.70728065
95* MP0000477_abnormal_intestine_morphology0.70561720
96MP0002166_altered_tumor_susceptibility0.69919189
97MP0004264_abnormal_extraembryonic_tissu0.68974877
98MP0003699_abnormal_female_reproductive0.68307396
99MP0003943_abnormal_hepatobiliary_system0.67939063
100MP0000678_abnormal_parathyroid_gland0.67411288
101MP0003385_abnormal_body_wall0.67283956
102MP0002697_abnormal_eye_size0.66974391
103MP0008995_early_reproductive_senescence0.66942305
104MP0000716_abnormal_immune_system0.66384314
105MP0008770_decreased_survivor_rate0.66162071
106MP0002006_tumorigenesis0.65672099
107MP0001881_abnormal_mammary_gland0.65507543
108MP0003942_abnormal_urinary_system0.64678880
109MP0001286_abnormal_eye_development0.64126125
110MP0000003_abnormal_adipose_tissue0.62497808
111MP0003283_abnormal_digestive_organ0.61578080
112MP0002925_abnormal_cardiovascular_devel0.61562994
113MP0002098_abnormal_vibrissa_morphology0.59480379
114MP0000733_abnormal_muscle_development0.59172090
115MP0003221_abnormal_cardiomyocyte_apopto0.59078622
116MP0000371_diluted_coat_color0.58978381
117MP0008260_abnormal_autophagy0.58867712
118MP0000432_abnormal_head_morphology0.57667634
119MP0002970_abnormal_white_adipose0.57447130
120MP0005666_abnormal_adipose_tissue0.57318049
121MP0005501_abnormal_skin_physiology0.55578114
122MP0005389_reproductive_system_phenotype0.55026797
123MP0003861_abnormal_nervous_system0.54034073
124MP0003941_abnormal_skin_development0.53927420
125MP0003115_abnormal_respiratory_system0.53369833
126MP0003935_abnormal_craniofacial_develop0.53307829
127MP0002877_abnormal_melanocyte_morpholog0.52885184
128* MP0002075_abnormal_coat/hair_pigmentati0.52461252
129MP0000266_abnormal_heart_morphology0.48783684
130MP0002938_white_spotting0.47879521

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.95131368
2Ependymoma (HP:0002888)4.20012297
3Chromsome breakage (HP:0040012)3.97163880
4Reticulocytopenia (HP:0001896)3.96911613
5Medulloblastoma (HP:0002885)3.86400885
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.81352707
7Colon cancer (HP:0003003)3.76379304
8Selective tooth agenesis (HP:0001592)3.67696765
9Breast hypoplasia (HP:0003187)3.61242079
10Microvesicular hepatic steatosis (HP:0001414)3.50882265
11Abnormality of cells of the erythroid lineage (HP:0012130)3.44217791
12Abnormal number of erythroid precursors (HP:0012131)3.26948327
13Agnosia (HP:0010524)3.25572296
14Progressive muscle weakness (HP:0003323)3.25117444
15Patellar aplasia (HP:0006443)3.20904409
16Hyperacusis (HP:0010780)3.18492984
17Abnormality of chromosome stability (HP:0003220)3.15331194
18Rhabdomyosarcoma (HP:0002859)3.09655171
19Oral leukoplakia (HP:0002745)2.98397806
20Aplasia/Hypoplasia of the patella (HP:0006498)2.97052937
21Meckel diverticulum (HP:0002245)2.96188345
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88253004
23Abnormality of the ileum (HP:0001549)2.86534016
24Basal cell carcinoma (HP:0002671)2.86309225
25Abnormality of the preputium (HP:0100587)2.84498826
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.82037867
27Abnormal number of incisors (HP:0011064)2.80535056
28Absent thumb (HP:0009777)2.80268550
29Abnormality of the astrocytes (HP:0100707)2.79238518
30Astrocytoma (HP:0009592)2.79238518
31Abnormality of the anterior horn cell (HP:0006802)2.72873468
32Degeneration of anterior horn cells (HP:0002398)2.72873468
33Myelodysplasia (HP:0002863)2.65730421
34High anterior hairline (HP:0009890)2.64798439
35Absent radius (HP:0003974)2.63522658
36Broad distal phalanx of finger (HP:0009836)2.59289080
37Insomnia (HP:0100785)2.59166998
38Increased nuchal translucency (HP:0010880)2.55692645
39Duodenal stenosis (HP:0100867)2.55042189
40Small intestinal stenosis (HP:0012848)2.55042189
41Neoplasm of the pancreas (HP:0002894)2.54519081
42Proximal placement of thumb (HP:0009623)2.53690697
43Neoplasm of striated muscle (HP:0009728)2.53078018
44Glioma (HP:0009733)2.49481632
45Neoplasm of the oral cavity (HP:0100649)2.49110461
46Aplastic anemia (HP:0001915)2.48898653
47Impulsivity (HP:0100710)2.45684777
48Absent forearm bone (HP:0003953)2.45408039
49Aplasia involving forearm bones (HP:0009822)2.45408039
50Ectopic kidney (HP:0000086)2.45162870
51Ragged-red muscle fibers (HP:0003200)2.45020066
52Deviation of the thumb (HP:0009603)2.44552881
53Abnormality of cochlea (HP:0000375)2.42628463
54Atresia of the external auditory canal (HP:0000413)2.40223576
5511 pairs of ribs (HP:0000878)2.40175897
56Carpal bone hypoplasia (HP:0001498)2.38949755
57Abnormality of the labia minora (HP:0012880)2.38458379
58Pallor (HP:0000980)2.31934607
59Progressive external ophthalmoplegia (HP:0000590)2.27860232
60Macrocytic anemia (HP:0001972)2.27554816
61Nephroblastoma (Wilms tumor) (HP:0002667)2.26435393
62Amaurosis fugax (HP:0100576)2.26250991
63Rough bone trabeculation (HP:0100670)2.25163240
64Tracheoesophageal fistula (HP:0002575)2.24221543
65Bone marrow hypocellularity (HP:0005528)2.24202823
66Overriding aorta (HP:0002623)2.21554910
67Short 4th metacarpal (HP:0010044)2.20996857
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20996857
69Cafe-au-lait spot (HP:0000957)2.19832416
70Sloping forehead (HP:0000340)2.19721162
71Septate vagina (HP:0001153)2.19191170
72High pitched voice (HP:0001620)2.19046733
73Abnormality of the carotid arteries (HP:0005344)2.18803011
74Missing ribs (HP:0000921)2.18546504
75Premature graying of hair (HP:0002216)2.18056529
76Abnormality of the duodenum (HP:0002246)2.16067433
77Duplicated collecting system (HP:0000081)2.13689321
78Trismus (HP:0000211)2.10540295
79Squamous cell carcinoma (HP:0002860)2.10291145
80Slender long bone (HP:0003100)2.09860296
81Abnormal gallbladder physiology (HP:0012438)2.09679517
82Cholecystitis (HP:0001082)2.09679517
83Abnormality of glycolysis (HP:0004366)2.07907088
84Duplication of thumb phalanx (HP:0009942)2.07181758
85Prominent nose (HP:0000448)2.07149946
86Overlapping toe (HP:0001845)2.06997336
87Embryonal renal neoplasm (HP:0011794)2.04057673
88Abnormal lung lobation (HP:0002101)2.03909758
89Supernumerary spleens (HP:0009799)2.03555172
90Microretrognathia (HP:0000308)2.02080725
91Abnormality of reticulocytes (HP:0004312)2.00316982
92Cellular immunodeficiency (HP:0005374)1.99595475
93Volvulus (HP:0002580)1.99387097
94Short thumb (HP:0009778)1.99360631
95Facial hemangioma (HP:0000329)1.98337840
96Poikiloderma (HP:0001029)1.97976172
97Elfin facies (HP:0004428)1.96019780
98Multiple enchondromatosis (HP:0005701)1.95709747
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.95703786
100Biliary tract neoplasm (HP:0100574)1.94940994
101Abdominal situs inversus (HP:0003363)1.93977807
102Abnormality of abdominal situs (HP:0011620)1.93977807
103Facial cleft (HP:0002006)1.93625262
104Horseshoe kidney (HP:0000085)1.92964326
105Triphalangeal thumb (HP:0001199)1.91843496
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91567819
107Choanal atresia (HP:0000453)1.91139369
108Neoplasm of the colon (HP:0100273)1.90664140
109Deep philtrum (HP:0002002)1.90188541
110Lymphoma (HP:0002665)1.90096651
111Abnormality of the renal collecting system (HP:0004742)1.89792823
112Rib fusion (HP:0000902)1.88948109
113Abnormality of the umbilical cord (HP:0010881)1.87111460
114Thrombocytosis (HP:0001894)1.86962749
115Cortical dysplasia (HP:0002539)1.86614342
116Cerebral hypomyelination (HP:0006808)1.86563681
117Angiofibromas (HP:0010615)1.85244701
118Adenoma sebaceum (HP:0009720)1.85244701
119Abnormality of chromosome segregation (HP:0002916)1.84490469
120Asplenia (HP:0001746)1.83953969
121Orthostatic hypotension (HP:0001278)1.83932435
122Abnormality of pyrimidine metabolism (HP:0004353)1.83751407
123Abnormality of the calcaneus (HP:0008364)1.83246256
124Premature ovarian failure (HP:0008209)1.82249160
125Renal duplication (HP:0000075)1.81925412
126Acute lymphatic leukemia (HP:0006721)1.80966988
127Ovarian neoplasm (HP:0100615)1.79358388
128Abnormality of DNA repair (HP:0003254)1.79343413
129Aplasia/hypoplasia of the humerus (HP:0006507)1.78923853
130Pseudobulbar signs (HP:0002200)1.78296590
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78135955
132Urethral obstruction (HP:0000796)1.78117447
133Freckling (HP:0001480)1.78030351
134Ulnar bowing (HP:0003031)1.77997398
135Deep palmar crease (HP:0006191)1.76315198
136Spastic diplegia (HP:0001264)1.75162733
137Asymmetry of the thorax (HP:0001555)1.73488632
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72479487
139Absent epiphyses (HP:0010577)1.72479487
140Abnormal umbilical cord blood vessels (HP:0011403)1.70893216
141Single umbilical artery (HP:0001195)1.70893216
142Abnormality of the fetal cardiovascular system (HP:0010948)1.70893216
143Long palpebral fissure (HP:0000637)1.69233959
144Arteriovenous malformation (HP:0100026)1.69025351
145Glossoptosis (HP:0000162)1.67606998
146Microglossia (HP:0000171)1.65286290
147Embryonal neoplasm (HP:0002898)1.65174276
148Morphological abnormality of the inner ear (HP:0011390)1.65116910
149Reticulocytosis (HP:0001923)1.64959497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.21855754
2SMG14.09729990
3BUB13.89578381
4* CDC73.71811049
5NEK23.04080786
6VRK22.74217193
7EEF2K2.73533477
8CDK122.65991316
9TTK2.48109872
10EIF2AK12.44894436
11TSSK62.30264075
12MAP3K102.17002252
13PASK2.16728965
14NEK12.10242231
15ACVR1B2.09194841
16RPS6KB22.04509935
17PLK11.95759275
18SRPK11.93829294
19TESK21.86656737
20* ATR1.85175768
21PBK1.76226311
22IRAK31.73133775
23CDK41.71078893
24PKN21.69509466
25SCYL21.68919676
26TLK11.68198264
27AURKB1.67048077
28STK101.66850671
29BRSK21.66593278
30* CDK71.62667437
31MKNK11.62058623
32NME21.59577684
33MAP3K81.59172487
34PLK41.57265749
35TAF11.55200771
36DYRK31.52887178
37PRPF4B1.52629750
38CHEK21.50457395
39VRK11.49509573
40RPS6KA41.45341616
41CHEK11.41374373
42TGFBR11.40861574
43EIF2AK31.38202991
44PAK41.33182474
45EPHA21.30478136
46PLK31.25240934
47BRSK11.21974795
48STK41.21375480
49BRD41.15400389
50FLT31.14379316
51MAP4K11.11956636
52MKNK21.05835954
53ATM1.03832794
54* AURKA1.01201236
55* CDK20.99174001
56PIM10.96186549
57BRAF0.94976380
58STK160.94553575
59ALK0.91559146
60LRRK20.89972499
61CCNB10.85692234
62CDK60.85598394
63MAP2K30.80266703
64CDK80.76330217
65ZAK0.74784694
66GRK60.72685772
67MELK0.71131978
68CDK10.70869185
69TRIB30.69098482
70MTOR0.68306032
71PAK10.66559081
72* CSNK2A20.63835306
73TAOK20.63493703
74NME10.63475461
75MAPKAPK30.62958006
76ARAF0.60518019
77CLK10.59210586
78KDR0.58871679
79STK30.57223463
80MST1R0.56641593
81TESK10.54770199
82SIK10.54452747
83RAF10.54361845
84AKT20.54057410
85CDK11A0.53964134
86* CSNK2A10.53445910
87BTK0.52523510
88MAP3K110.51998958
89CDK150.50255172
90PRKCI0.48013176
91FGFR40.47315480
92CDK180.46171991
93RPS6KA50.44390738
94PRKDC0.42524041
95MAP2K20.40909732
96CDK140.39457243
97CSNK1G30.39234342
98IRAK20.39187448
99BCKDK0.38602533
100CSNK1E0.38504676
101PAK20.37379128
102CSNK1D0.37246634
103MAPK110.37234742
104KSR20.36789172
105FGFR10.35753459
106CAMK1D0.35708286
107CSF1R0.34384045
108TTN0.33935478
109DAPK10.33832047
110CDK30.33429657
111MAPK140.32400306
112ZAP700.31127744
113JAK30.29941799
114ICK0.29794919
115AKT10.29623730
116PIM20.26928300
117RPS6KA10.26663158
118CDK90.25967008
119EIF2AK20.23488873
120MAPK10.23484269
121ILK0.22783758
122LATS20.22533742
123MAPKAPK20.22058911
124RPS6KL10.22017164
125RPS6KC10.22017164

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.62290053
2Mismatch repair_Homo sapiens_hsa034304.78994680
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33614758
4Base excision repair_Homo sapiens_hsa034103.31731891
5Spliceosome_Homo sapiens_hsa030403.31352653
6Homologous recombination_Homo sapiens_hsa034403.12685535
7RNA transport_Homo sapiens_hsa030133.07805303
8One carbon pool by folate_Homo sapiens_hsa006703.02685856
9Nucleotide excision repair_Homo sapiens_hsa034202.94726899
10* Cell cycle_Homo sapiens_hsa041102.93909096
11Ribosome_Homo sapiens_hsa030102.81398768
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63433238
13RNA polymerase_Homo sapiens_hsa030202.50165536
14Proteasome_Homo sapiens_hsa030502.29189361
15Fanconi anemia pathway_Homo sapiens_hsa034602.27505709
16Pyrimidine metabolism_Homo sapiens_hsa002402.22191753
17Non-homologous end-joining_Homo sapiens_hsa034502.18889831
18mRNA surveillance pathway_Homo sapiens_hsa030151.86545943
19RNA degradation_Homo sapiens_hsa030181.78825964
20p53 signaling pathway_Homo sapiens_hsa041151.63430472
21Basal transcription factors_Homo sapiens_hsa030221.55704735
22Systemic lupus erythematosus_Homo sapiens_hsa053221.44648256
23Viral carcinogenesis_Homo sapiens_hsa052031.14715066
24Epstein-Barr virus infection_Homo sapiens_hsa051691.11630368
25Purine metabolism_Homo sapiens_hsa002301.08429964
26Herpes simplex infection_Homo sapiens_hsa051680.99783922
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98888666
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94307249
29Oocyte meiosis_Homo sapiens_hsa041140.93385337
30Biosynthesis of amino acids_Homo sapiens_hsa012300.93319659
31Antigen processing and presentation_Homo sapiens_hsa046120.92682886
32HTLV-I infection_Homo sapiens_hsa051660.92033719
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89583337
34Selenocompound metabolism_Homo sapiens_hsa004500.88514921
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.82900552
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82374229
37Pyruvate metabolism_Homo sapiens_hsa006200.82095148
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.81764748
39MicroRNAs in cancer_Homo sapiens_hsa052060.81402031
40Thyroid cancer_Homo sapiens_hsa052160.79176885
41Pentose phosphate pathway_Homo sapiens_hsa000300.78381811
42Small cell lung cancer_Homo sapiens_hsa052220.75175069
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74934594
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67252418
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63461479
46Basal cell carcinoma_Homo sapiens_hsa052170.62067037
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60357650
48Notch signaling pathway_Homo sapiens_hsa043300.59244028
49Chronic myeloid leukemia_Homo sapiens_hsa052200.58301716
50Folate biosynthesis_Homo sapiens_hsa007900.58278124
51Colorectal cancer_Homo sapiens_hsa052100.58230414
52Primary immunodeficiency_Homo sapiens_hsa053400.57787518
53Alcoholism_Homo sapiens_hsa050340.56967220
54Legionellosis_Homo sapiens_hsa051340.56555574
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.56332005
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55911749
57Sulfur relay system_Homo sapiens_hsa041220.53149908
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52631776
59Apoptosis_Homo sapiens_hsa042100.51991190
60Hippo signaling pathway_Homo sapiens_hsa043900.50713817
61Bladder cancer_Homo sapiens_hsa052190.50011459
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.45623928
63Hepatitis B_Homo sapiens_hsa051610.45245968
64TGF-beta signaling pathway_Homo sapiens_hsa043500.44817256
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44356622
66Carbon metabolism_Homo sapiens_hsa012000.43739042
67Glioma_Homo sapiens_hsa052140.42384331
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42154497
69Measles_Homo sapiens_hsa051620.40861913
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39839067
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38452143
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38288550
73Shigellosis_Homo sapiens_hsa051310.37881875
74Acute myeloid leukemia_Homo sapiens_hsa052210.37101338
75N-Glycan biosynthesis_Homo sapiens_hsa005100.36719510
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35990523
77Non-small cell lung cancer_Homo sapiens_hsa052230.35827720
78Fatty acid elongation_Homo sapiens_hsa000620.35479548
79Lysine degradation_Homo sapiens_hsa003100.35401861
80Pathways in cancer_Homo sapiens_hsa052000.33991482
81mTOR signaling pathway_Homo sapiens_hsa041500.33406457
82Hedgehog signaling pathway_Homo sapiens_hsa043400.32759502
83Glutathione metabolism_Homo sapiens_hsa004800.31542306
84Adherens junction_Homo sapiens_hsa045200.31498098
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.30877555
86Viral myocarditis_Homo sapiens_hsa054160.30818308
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30644735
88HIF-1 signaling pathway_Homo sapiens_hsa040660.30445393
89Vitamin B6 metabolism_Homo sapiens_hsa007500.28871333
90Steroid biosynthesis_Homo sapiens_hsa001000.28357660
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26957612
92Prostate cancer_Homo sapiens_hsa052150.25450309
93Influenza A_Homo sapiens_hsa051640.25102020
94Fructose and mannose metabolism_Homo sapiens_hsa000510.24314106
95Pancreatic cancer_Homo sapiens_hsa052120.24153502
96Huntingtons disease_Homo sapiens_hsa050160.23259219
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21916090
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21559822
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21032270
100AMPK signaling pathway_Homo sapiens_hsa041520.20918049
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20412455
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19912422
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18971233
104Hematopoietic cell lineage_Homo sapiens_hsa046400.18284992
105Galactose metabolism_Homo sapiens_hsa000520.18040309
106Arginine and proline metabolism_Homo sapiens_hsa003300.17191839
107Metabolic pathways_Homo sapiens_hsa011000.17047255
108Insulin signaling pathway_Homo sapiens_hsa049100.16771317
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16639850
110Renin-angiotensin system_Homo sapiens_hsa046140.16151338
111Arginine biosynthesis_Homo sapiens_hsa002200.15937779
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15514100
113Proteoglycans in cancer_Homo sapiens_hsa052050.14946159
114Wnt signaling pathway_Homo sapiens_hsa043100.14777116
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14303328
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13886546
117B cell receptor signaling pathway_Homo sapiens_hsa046620.13187568
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.12983891
119Melanoma_Homo sapiens_hsa052180.12228634
120Endometrial cancer_Homo sapiens_hsa052130.11586866

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