MCM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.89328369
2DNA strand elongation involved in DNA replication (GO:0006271)4.88015837
3DNA replication initiation (GO:0006270)4.79611595
4protein localization to kinetochore (GO:0034501)4.64100082
5DNA strand elongation (GO:0022616)4.63993361
6folic acid-containing compound biosynthetic process (GO:0009396)4.56832472
7DNA replication checkpoint (GO:0000076)4.47653026
8nucleobase biosynthetic process (GO:0046112)4.46712483
9telomere maintenance via semi-conservative replication (GO:0032201)4.40698035
10mitotic metaphase plate congression (GO:0007080)4.32678390
11purine nucleobase biosynthetic process (GO:0009113)4.28987039
12nuclear pore organization (GO:0006999)4.20771110
13DNA replication-dependent nucleosome organization (GO:0034723)4.17447901
14DNA replication-dependent nucleosome assembly (GO:0006335)4.17447901
15IMP biosynthetic process (GO:0006188)4.13025794
16establishment of integrated proviral latency (GO:0075713)4.10751659
17mitotic sister chromatid cohesion (GO:0007064)4.03445357
18protein localization to chromosome, centromeric region (GO:0071459)4.02089192
19nuclear pore complex assembly (GO:0051292)4.00734334
20telomere maintenance via recombination (GO:0000722)3.97502777
21mitotic nuclear envelope disassembly (GO:0007077)3.94842585
22mitotic sister chromatid segregation (GO:0000070)3.93372006
23glycine metabolic process (GO:0006544)3.92601692
24regulation of centriole replication (GO:0046599)3.92157142
25mitotic recombination (GO:0006312)3.90007104
26chromatin remodeling at centromere (GO:0031055)3.84359263
27kinetochore organization (GO:0051383)3.84200775
28CENP-A containing nucleosome assembly (GO:0034080)3.78877083
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77870176
30DNA topological change (GO:0006265)3.73494529
31metaphase plate congression (GO:0051310)3.73350122
32DNA ligation (GO:0006266)3.69180402
33folic acid metabolic process (GO:0046655)3.69092019
34replication fork processing (GO:0031297)3.68509131
35mitotic chromosome condensation (GO:0007076)3.68376876
36double-strand break repair via nonhomologous end joining (GO:0006303)3.66953955
37non-recombinational repair (GO:0000726)3.66953955
38sister chromatid segregation (GO:0000819)3.63353456
39nuclear envelope disassembly (GO:0051081)3.61117428
40membrane disassembly (GO:0030397)3.61117428
41regulation of spindle organization (GO:0090224)3.59831754
42formation of translation preinitiation complex (GO:0001731)3.58116461
43IMP metabolic process (GO:0046040)3.57612025
44telomere maintenance via telomere lengthening (GO:0010833)3.55889967
45tetrahydrofolate metabolic process (GO:0046653)3.50677514
46DNA replication-independent nucleosome organization (GO:0034724)3.49724634
47DNA replication-independent nucleosome assembly (GO:0006336)3.49724634
48translesion synthesis (GO:0019985)3.48777747
49regulation of DNA endoreduplication (GO:0032875)3.48700068
50maturation of SSU-rRNA (GO:0030490)3.45750633
51ribosome assembly (GO:0042255)3.45017718
52kinetochore assembly (GO:0051382)3.43546908
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42871502
54DNA duplex unwinding (GO:0032508)3.41967327
55DNA geometric change (GO:0032392)3.41557140
56chromosome condensation (GO:0030261)3.41046293
57attachment of spindle microtubules to kinetochore (GO:0008608)3.38420966
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36729277
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.36729277
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.36361734
61ribosome biogenesis (GO:0042254)3.35248251
62establishment of chromosome localization (GO:0051303)3.32842735
63postreplication repair (GO:0006301)3.31132923
64serine family amino acid biosynthetic process (GO:0009070)3.30477403
65DNA double-strand break processing (GO:0000729)3.24146365
66ATP-dependent chromatin remodeling (GO:0043044)3.23667549
67histone exchange (GO:0043486)3.23459910
68base-excision repair (GO:0006284)3.17398363
69meiotic chromosome segregation (GO:0045132)3.17063541
70* DNA replication (GO:0006260)3.16995896
71positive regulation of chromosome segregation (GO:0051984)3.16418725
72transcription-coupled nucleotide-excision repair (GO:0006283)3.16342805
73mitotic G2/M transition checkpoint (GO:0044818)3.16103597
74regulation of histone H3-K9 methylation (GO:0051570)3.15145648
75pore complex assembly (GO:0046931)3.14746426
76* G1/S transition of mitotic cell cycle (GO:0000082)3.14334410
77* cell cycle G1/S phase transition (GO:0044843)3.14334410
78* mitotic cell cycle (GO:0000278)3.14033521
79regulation of nuclear cell cycle DNA replication (GO:0033262)3.12768946
80DNA strand renaturation (GO:0000733)3.12536978
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.12502347
82regulation of mitotic spindle organization (GO:0060236)3.11773177
83regulation of sister chromatid segregation (GO:0033045)3.11480620
84regulation of mitotic sister chromatid separation (GO:0010965)3.11480620
85regulation of mitotic sister chromatid segregation (GO:0033047)3.11480620
86DNA packaging (GO:0006323)3.09955537
87DNA synthesis involved in DNA repair (GO:0000731)3.06746493
88L-serine metabolic process (GO:0006563)3.05702793
89folic acid-containing compound metabolic process (GO:0006760)3.05097751
90establishment of viral latency (GO:0019043)3.04693001
91mitotic spindle assembly checkpoint (GO:0007094)3.03456712
92ribosomal small subunit assembly (GO:0000028)2.99609135
93chromatin assembly or disassembly (GO:0006333)2.98188874
94regulation of helicase activity (GO:0051095)2.97611023
95regulation of centrosome cycle (GO:0046605)2.97163300
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.97054448
97protein K6-linked ubiquitination (GO:0085020)2.96285070
98regulation of chromosome segregation (GO:0051983)2.95298301
99ribonucleoprotein complex biogenesis (GO:0022613)2.94681798
100spindle checkpoint (GO:0031577)2.94576584
101chromosome segregation (GO:0007059)2.93415805
102pteridine-containing compound biosynthetic process (GO:0042559)2.93394677
103regulation of gene silencing by RNA (GO:0060966)2.93088662
104regulation of posttranscriptional gene silencing (GO:0060147)2.93088662
105regulation of gene silencing by miRNA (GO:0060964)2.93088662
106protein localization to chromosome (GO:0034502)2.91156184
107spliceosomal snRNP assembly (GO:0000387)2.90915691
108pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.90676552
109serine family amino acid metabolic process (GO:0009069)2.88526696
110DNA conformation change (GO:0071103)2.87148428
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86713277
112telomere organization (GO:0032200)2.86383660
113telomere maintenance (GO:0000723)2.86184257
114negative regulation of histone methylation (GO:0031061)2.85911288
115negative regulation of chromosome segregation (GO:0051985)2.85749262
116mismatch repair (GO:0006298)2.84452283
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83857662
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80547662
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.78919643
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78919643
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78919643
122negative regulation of sister chromatid segregation (GO:0033046)2.78919643
123rRNA processing (GO:0006364)2.77963907
124nuclear envelope organization (GO:0006998)2.77048341
125spindle assembly checkpoint (GO:0071173)2.75118545
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74753152
127heterochromatin organization (GO:0070828)2.73105268
128mitotic spindle checkpoint (GO:0071174)2.71710030
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71468749
130ribosomal large subunit biogenesis (GO:0042273)2.70407754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.88049148
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53089100
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91566325
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81555354
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29730926
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15644759
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79049664
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66442054
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65057170
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56099156
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48328621
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.46409258
13* AR_21909140_ChIP-Seq_LNCAP_Human2.28328812
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.25580194
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24245194
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23989315
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20566412
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.05668775
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.04789842
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04527231
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.03950039
22XRN2_22483619_ChIP-Seq_HELA_Human2.03932932
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98101446
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97729226
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94066051
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91015821
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85823146
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84316496
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83684901
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80302444
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78811011
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77439395
33VDR_23849224_ChIP-Seq_CD4+_Human1.77224498
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75171428
35FOXP3_21729870_ChIP-Seq_TREG_Human1.70075538
36DCP1A_22483619_ChIP-Seq_HELA_Human1.65379976
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62462165
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54846702
39GABP_19822575_ChIP-Seq_HepG2_Human1.54626404
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54446379
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53543973
42TTF2_22483619_ChIP-Seq_HELA_Human1.51215713
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48461763
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47000004
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45434635
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41771693
47KDM5A_27292631_Chip-Seq_BREAST_Human1.41182510
48MYC_22102868_ChIP-Seq_BL_Human1.40135466
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39383540
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36672791
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.35853649
52CIITA_25753668_ChIP-Seq_RAJI_Human1.35731169
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33696123
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33268253
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33053716
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30592139
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30538390
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29905606
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27558251
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.26929019
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22583259
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20406467
63ELK1_19687146_ChIP-ChIP_HELA_Human1.19508878
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18725436
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18682806
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18380438
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.16552291
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15597452
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15323542
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15278223
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14828049
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13947312
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13783664
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13346743
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13346743
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13346743
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12318240
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09807117
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.07573302
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06612689
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.03970016
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03089600
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.03001933
84* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02449718
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01712500
86TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97463262
87TFEB_21752829_ChIP-Seq_HELA_Human0.97322607
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96227534
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95397001
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95383337
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94163438
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94011516
93* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93929313
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.93359192
95EWS_26573619_Chip-Seq_HEK293_Human0.91068990
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.90909206
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90705884
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90232857
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89127997
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.89075933
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88912961
102MYC_18940864_ChIP-ChIP_HL60_Human0.87482583
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87377772
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.87130841
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86664191
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84739971
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84157115
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83402189
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83022024
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82178430
111* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81868919
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81818252
113IRF1_19129219_ChIP-ChIP_H3396_Human0.81324025
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76915138
115CHD1_26751641_Chip-Seq_LNCaP_Human0.72734030
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71133822
117* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71094914
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66579106
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66029049
120FUS_26573619_Chip-Seq_HEK293_Human0.64655165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.95744046
2MP0010094_abnormal_chromosome_stability4.51381155
3MP0003111_abnormal_nucleus_morphology4.43223483
4MP0008057_abnormal_DNA_replication4.05043254
5MP0004957_abnormal_blastocyst_morpholog4.02529212
6MP0003806_abnormal_nucleotide_metabolis3.76805600
7MP0003077_abnormal_cell_cycle3.64977041
8MP0008058_abnormal_DNA_repair2.96542129
9MP0002139_abnormal_hepatobiliary_system2.90392696
10MP0005360_urolithiasis2.62265266
11MP0008932_abnormal_embryonic_tissue2.32566370
12MP0001730_embryonic_growth_arrest2.31924335
13MP0006292_abnormal_olfactory_placode2.30167751
14MP0005085_abnormal_gallbladder_physiolo2.27893876
15MP0008007_abnormal_cellular_replicative2.22686966
16MP0003718_maternal_effect2.12527776
17MP0010352_gastrointestinal_tract_polyps2.09179859
18MP0000350_abnormal_cell_proliferation2.05949348
19MP0010307_abnormal_tumor_latency2.01863481
20MP0005365_abnormal_bile_salt1.93566843
21MP0003123_paternal_imprinting1.85609618
22MP0001672_abnormal_embryogenesis/_devel1.80979709
23MP0005380_embryogenesis_phenotype1.80979709
24MP0003786_premature_aging1.68188766
25MP0008877_abnormal_DNA_methylation1.65656012
26MP0001697_abnormal_embryo_size1.60806292
27MP0003984_embryonic_growth_retardation1.57200124
28MP0002088_abnormal_embryonic_growth/wei1.55196369
29MP0003890_abnormal_embryonic-extraembry1.52845724
30MP0002396_abnormal_hematopoietic_system1.50406151
31MP0002938_white_spotting1.49487048
32MP0002080_prenatal_lethality1.49376257
33MP0009840_abnormal_foam_cell1.46799844
34MP0002085_abnormal_embryonic_tissue1.44850778
35MP0002086_abnormal_extraembryonic_tissu1.43872009
36MP0004197_abnormal_fetal_growth/weight/1.39819913
37MP0003941_abnormal_skin_development1.38275384
38MP0003186_abnormal_redox_activity1.37345806
39MP0003705_abnormal_hypodermis_morpholog1.33490081
40MP0002084_abnormal_developmental_patter1.32796621
41MP0000490_abnormal_crypts_of1.31684351
42MP0002019_abnormal_tumor_incidence1.28774630
43MP0008875_abnormal_xenobiotic_pharmacok1.28471049
44MP0003567_abnormal_fetal_cardiomyocyte1.27260311
45MP0000566_synostosis1.26630364
46MP0005076_abnormal_cell_differentiation1.25441126
47MP0000313_abnormal_cell_death1.24856415
48MP0009053_abnormal_anal_canal1.24350187
49MP0002697_abnormal_eye_size1.20687152
50MP0009672_abnormal_birth_weight1.20365844
51MP0001346_abnormal_lacrimal_gland1.18762897
52MP0010030_abnormal_orbit_morphology1.09841931
53MP0002210_abnormal_sex_determination1.06644784
54MP0003119_abnormal_digestive_system1.05135497
55MP0002234_abnormal_pharynx_morphology1.02203546
56MP0009697_abnormal_copulation1.01919548
57MP0001293_anophthalmia1.01583796
58MP0001764_abnormal_homeostasis0.95234974
59MP0005266_abnormal_metabolism0.94802888
60MP0001145_abnormal_male_reproductive0.94369186
61MP0000609_abnormal_liver_physiology0.93083758
62MP0000428_abnormal_craniofacial_morphol0.91195910
63MP0010329_abnormal_lipoprotein_level0.90310207
64MP0003252_abnormal_bile_duct0.90191360
65MP0000598_abnormal_liver_morphology0.90125659
66MP0008995_early_reproductive_senescence0.90097998
67MP0001119_abnormal_female_reproductive0.89926882
68MP0002233_abnormal_nose_morphology0.89393384
69MP0005332_abnormal_amino_acid0.88146361
70MP0001545_abnormal_hematopoietic_system0.87001946
71MP0005397_hematopoietic_system_phenotyp0.87001946
72MP0002160_abnormal_reproductive_system0.86240553
73MP0004808_abnormal_hematopoietic_stem0.85544500
74MP0000653_abnormal_sex_gland0.85463720
75MP0004133_heterotaxia0.85449622
76MP0002111_abnormal_tail_morphology0.85219248
77MP0001915_intracranial_hemorrhage0.84261953
78MP0002009_preneoplasia0.82671402
79MP0003121_genomic_imprinting0.82594331
80MP0005408_hypopigmentation0.82178679
81MP0003315_abnormal_perineum_morphology0.81910073
82MP0002653_abnormal_ependyma_morphology0.81846923
83MP0006036_abnormal_mitochondrial_physio0.81473218
84MP0001929_abnormal_gametogenesis0.80604028
85MP0009703_decreased_birth_body0.79890718
86MP0003861_abnormal_nervous_system0.79627282
87MP0006072_abnormal_retinal_apoptosis0.79393330
88MP0005023_abnormal_wound_healing0.78155722
89MP0005319_abnormal_enzyme/_coenzyme0.77800822
90MP0001529_abnormal_vocalization0.76744241
91MP0004264_abnormal_extraembryonic_tissu0.76725578
92MP0000049_abnormal_middle_ear0.76023643
93MP0008789_abnormal_olfactory_epithelium0.75206088
94MP0005083_abnormal_biliary_tract0.74328850
95MP0005187_abnormal_penis_morphology0.72887033
96MP0003755_abnormal_palate_morphology0.71954063
97MP0005395_other_phenotype0.71095488
98MP0009379_abnormal_foot_pigmentation0.71075916
99MP0005389_reproductive_system_phenotype0.70173988
100MP0000372_irregular_coat_pigmentation0.69991564
101MP0000647_abnormal_sebaceous_gland0.69919556
102MP0000358_abnormal_cell_content/0.69469274
103MP0002722_abnormal_immune_system0.69309774
104MP0003698_abnormal_male_reproductive0.69145711
105MP0000689_abnormal_spleen_morphology0.68841113
106MP0004233_abnormal_muscle_weight0.67701859
107MP0000537_abnormal_urethra_morphology0.67423206
108MP0009333_abnormal_splenocyte_physiolog0.67322219
109MP0005384_cellular_phenotype0.67145761
110MP0004147_increased_porphyrin_level0.66929714
111MP0003699_abnormal_female_reproductive0.66831340
112MP0001661_extended_life_span0.66520835
113MP0003136_yellow_coat_color0.66141086
114MP0005075_abnormal_melanosome_morpholog0.65851040
115MP0002161_abnormal_fertility/fecundity0.65550777
116MP0003656_abnormal_erythrocyte_physiolo0.65543121
117MP0002092_abnormal_eye_morphology0.65465119
118MP0000703_abnormal_thymus_morphology0.64997533
119MP0003566_abnormal_cell_adhesion0.64985615
120MP0005621_abnormal_cell_physiology0.64360423
121MP0002102_abnormal_ear_morphology0.63732793
122MP0002163_abnormal_gland_morphology0.63417226
123MP0001727_abnormal_embryo_implantation0.63192112
124MP0004019_abnormal_vitamin_homeostasis0.63083232
125MP0003935_abnormal_craniofacial_develop0.62626657
126MP0000631_abnormal_neuroendocrine_gland0.62159080
127MP0003221_abnormal_cardiomyocyte_apopto0.60981328
128MP0004185_abnormal_adipocyte_glucose0.60484225
129MP0005391_vision/eye_phenotype0.60390563
130MP0002132_abnormal_respiratory_system0.59427014
131MP0003942_abnormal_urinary_system0.59377063
132MP0000477_abnormal_intestine_morphology0.59342676
133MP0003943_abnormal_hepatobiliary_system0.59264164
134MP0001286_abnormal_eye_development0.59184083
135MP0003937_abnormal_limbs/digits/tail_de0.58722792
136MP0006035_abnormal_mitochondrial_morpho0.58517207
137MP0002877_abnormal_melanocyte_morpholog0.58195257
138MP0000371_diluted_coat_color0.55977070

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78799905
2Abnormality of pyrimidine metabolism (HP:0004353)4.27915344
3Chromsome breakage (HP:0040012)4.22311492
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18156155
5Breast hypoplasia (HP:0003187)4.02075795
6Impulsivity (HP:0100710)3.71180712
7Ependymoma (HP:0002888)3.61130746
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58580035
9Oral leukoplakia (HP:0002745)3.33539603
10Abnormality of chromosome stability (HP:0003220)3.33079557
11Hypobetalipoproteinemia (HP:0003563)3.27209445
12Medulloblastoma (HP:0002885)3.22255228
13Degeneration of anterior horn cells (HP:0002398)3.20321955
14Abnormality of the anterior horn cell (HP:0006802)3.20321955
15Intrahepatic cholestasis (HP:0001406)3.18011568
16Reticulocytopenia (HP:0001896)3.12100717
17Meckel diverticulum (HP:0002245)3.11565323
18Abnormality of the preputium (HP:0100587)3.04910324
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.01253851
20Rhabdomyosarcoma (HP:0002859)3.01148968
21Abnormality of the ileum (HP:0001549)3.00109141
22Patellar aplasia (HP:0006443)2.99564339
23Agnosia (HP:0010524)2.97402142
24Hyperglycinemia (HP:0002154)2.94933823
25Carpal bone hypoplasia (HP:0001498)2.90001882
26Selective tooth agenesis (HP:0001592)2.87108697
27Nephroblastoma (Wilms tumor) (HP:0002667)2.86263993
28Colon cancer (HP:0003003)2.84581283
29Absent radius (HP:0003974)2.81008558
30Aplasia/Hypoplasia of the patella (HP:0006498)2.78193050
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72865619
32Embryonal renal neoplasm (HP:0011794)2.71126535
33Absent forearm bone (HP:0003953)2.60093128
34Aplasia involving forearm bones (HP:0009822)2.60093128
35Abnormality of cochlea (HP:0000375)2.57987393
36Hyperglycinuria (HP:0003108)2.55769989
37Abnormality of the labia minora (HP:0012880)2.49301830
38Absent thumb (HP:0009777)2.48333363
39Duodenal stenosis (HP:0100867)2.48212598
40Small intestinal stenosis (HP:0012848)2.48212598
41Volvulus (HP:0002580)2.47294017
42Microvesicular hepatic steatosis (HP:0001414)2.39897574
43Rough bone trabeculation (HP:0100670)2.39017670
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.38002829
45Myelodysplasia (HP:0002863)2.37566550
46Spastic diplegia (HP:0001264)2.34360446
47Ectopic kidney (HP:0000086)2.32729426
48Abnormality of methionine metabolism (HP:0010901)2.31178190
49Bone marrow hypocellularity (HP:0005528)2.31026482
50Abnormality of glycine metabolism (HP:0010895)2.30706803
51Abnormality of serine family amino acid metabolism (HP:0010894)2.30706803
52Hypochromic microcytic anemia (HP:0004840)2.27147563
53Deep venous thrombosis (HP:0002625)2.21635491
54Abnormality of the duodenum (HP:0002246)2.21433207
55Astrocytoma (HP:0009592)2.20517366
56Abnormality of the astrocytes (HP:0100707)2.20517366
57Pseudobulbar signs (HP:0002200)2.20299922
58Neoplasm of striated muscle (HP:0009728)2.19471163
59Glioma (HP:0009733)2.18694656
60Abnormal number of incisors (HP:0011064)2.18214953
61Supernumerary spleens (HP:0009799)2.16907182
62Horseshoe kidney (HP:0000085)2.16857557
63Neoplasm of the pancreas (HP:0002894)2.15531964
64Sloping forehead (HP:0000340)2.14878806
65Abnormality of cells of the erythroid lineage (HP:0012130)2.14495394
66Megaloblastic anemia (HP:0001889)2.13370688
67Squamous cell carcinoma (HP:0002860)2.13121008
68Abnormality of serum amino acid levels (HP:0003112)2.11978396
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09974444
70Arteriovenous malformation (HP:0100026)2.09342537
71Cortical dysplasia (HP:0002539)2.09142301
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08472287
73Duplication of thumb phalanx (HP:0009942)2.08389422
74Premature ovarian failure (HP:0008209)2.06940887
75Multiple enchondromatosis (HP:0005701)2.05016068
76Choanal atresia (HP:0000453)2.04435118
77Cerebral hypomyelination (HP:0006808)2.04220197
78Cellular immunodeficiency (HP:0005374)2.03929912
79Hypolipoproteinemia (HP:0010981)2.03370452
80Abnormal number of erythroid precursors (HP:0012131)2.03112147
81Macrocytic anemia (HP:0001972)1.98958091
82Abnormality of reticulocytes (HP:0004312)1.98387627
83Duplicated collecting system (HP:0000081)1.97016019
84Basal cell carcinoma (HP:0002671)1.96800223
85Tracheoesophageal fistula (HP:0002575)1.96345463
86Triphalangeal thumb (HP:0001199)1.95185979
87Cafe-au-lait spot (HP:0000957)1.94747251
88Facial cleft (HP:0002006)1.93868499
89Proximal placement of thumb (HP:0009623)1.93697924
90Pancytopenia (HP:0001876)1.93639116
91Hyperammonemia (HP:0001987)1.93159502
92Abnormality of the carotid arteries (HP:0005344)1.92433282
93Biliary tract neoplasm (HP:0100574)1.91556520
94Clubbing of toes (HP:0100760)1.89288510
95Abnormality of glycolysis (HP:0004366)1.88840763
96Abnormality of nucleobase metabolism (HP:0010932)1.88420152
97Abnormal lung lobation (HP:0002101)1.87424182
98Increased hepatocellular lipid droplets (HP:0006565)1.87208213
99Morphological abnormality of the inner ear (HP:0011390)1.85609008
100Deviation of the thumb (HP:0009603)1.84917466
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84870471
102Increased serum pyruvate (HP:0003542)1.84721956
103Increased nuchal translucency (HP:0010880)1.83847171
104Hypoplasia of the pons (HP:0012110)1.83631482
105Premature graying of hair (HP:0002216)1.82694529
106High pitched voice (HP:0001620)1.82678942
107Abnormality of the renal collecting system (HP:0004742)1.81586275
108Short thumb (HP:0009778)1.81495668
109Hypoplastic pelvis (HP:0008839)1.81454314
110Neoplasm of the colon (HP:0100273)1.81400530
111Progressive muscle weakness (HP:0003323)1.81298895
112Pallor (HP:0000980)1.81023456
113Aplastic anemia (HP:0001915)1.79533481
114Microretrognathia (HP:0000308)1.79360174
115Neoplasm of the oral cavity (HP:0100649)1.78575465
116Prolonged partial thromboplastin time (HP:0003645)1.78282605
117Embryonal neoplasm (HP:0002898)1.77764105
118Facial hemangioma (HP:0000329)1.77696489
119High anterior hairline (HP:0009890)1.77523591
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.77129010
121Abnormality of DNA repair (HP:0003254)1.77095404
122Atresia of the external auditory canal (HP:0000413)1.76393275
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.75929914
124Secondary amenorrhea (HP:0000869)1.75067178
125Progressive external ophthalmoplegia (HP:0000590)1.73205081
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73198172
127Amaurosis fugax (HP:0100576)1.73034608
128Acute necrotizing encephalopathy (HP:0006965)1.72923184
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72608364
130Acute encephalopathy (HP:0006846)1.72069193
131Abnormal trabecular bone morphology (HP:0100671)1.71821922
132Overlapping toe (HP:0001845)1.71362151
133Lipid accumulation in hepatocytes (HP:0006561)1.68602906
134Abnormality of chromosome segregation (HP:0002916)1.67713139
135Abnormality of the pons (HP:0007361)1.67161464
136Abnormal mitochondria in muscle tissue (HP:0008316)1.65111732
137Short middle phalanx of the 5th finger (HP:0004220)1.60655643
138Abnormal umbilical cord blood vessels (HP:0011403)1.59707445
139Single umbilical artery (HP:0001195)1.59707445
140Abnormality of the fetal cardiovascular system (HP:0010948)1.59707445
141Cleft eyelid (HP:0000625)1.58876574
142Increased CSF lactate (HP:0002490)1.57135004
143Septate vagina (HP:0001153)1.56738302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.84743815
2WEE14.31784400
3BUB14.06535018
4NEK23.05283609
5TTK2.90429935
6NEK12.69509443
7EIF2AK12.68706043
8VRK22.62150419
9SRPK12.61881992
10PLK42.31527796
11PASK2.30128026
12PLK12.22132549
13TSSK62.18635740
14CDK122.13151186
15MKNK11.98064072
16ACVR1B1.87108739
17EPHA21.84710159
18ATR1.82568001
19CDK71.77274459
20AURKB1.74617611
21TLK11.73556886
22TAF11.72412663
23BRSK21.71659162
24PLK31.70555983
25CDK41.63527319
26RPS6KB21.54473138
27CHEK21.52192167
28TESK21.47082253
29MAP3K81.45446820
30MST41.43935962
31AURKA1.43379072
32BCKDK1.41304943
33ZAK1.37899763
34EIF2AK31.37089568
35CDK81.36932935
36CHEK11.33673365
37NME21.32606922
38MKNK21.32170759
39STK41.31879738
40VRK11.29597671
41STK161.27140769
42SMG11.26169673
43DYRK31.21519466
44NUAK11.20484935
45STK101.20050495
46BRSK11.16674484
47NME11.10423830
48EEF2K1.09320797
49STK38L0.98906207
50TGFBR10.97841965
51CDK20.97598167
52ATM0.95719457
53RPS6KA40.95213685
54PIM10.94840130
55CDK60.93597132
56MELK0.93194965
57FLT30.92124851
58SCYL20.90756586
59EIF2AK20.88618394
60PAK40.87120422
61PKN20.83428733
62MAP3K100.83416503
63TRIM280.82207179
64ALK0.82175816
65CLK10.81902517
66PNCK0.81010962
67CCNB10.80643517
68STK30.80003851
69AKT30.79431519
70BRD40.78842915
71BMPR1B0.77675183
72CDK10.72245437
73LATS10.71040028
74CSNK2A20.69959524
75CSNK2A10.67310080
76LATS20.65148745
77MAP2K30.64867527
78BRAF0.63810394
79ERBB40.60724440
80MTOR0.58412919
81CSNK1G10.57801821
82CSNK1G30.57572098
83TNIK0.55447501
84PBK0.53710089
85MAPK110.53466813
86PRKCI0.52873428
87PAK10.51781719
88CSNK1A1L0.51197040
89MAPKAPK30.50700548
90CSNK1E0.48223300
91PLK20.45766262
92CDK30.44479774
93WNK30.42501703
94KDR0.41464055
95AKT20.40713598
96GRK60.40608760
97MAP3K40.38847972
98RPS6KA50.38545080
99CSNK1D0.38329346
100CDK90.38117801
101PDK20.37066008
102MAPKAPK50.36812683
103MAP3K110.36179023
104TAOK20.34236038
105DYRK20.33625410
106PRKDC0.33020260
107CSNK1G20.32764902
108MAPK140.32128477
109NEK90.30115691
110LRRK20.29224810
111PIM20.29079182
112CDK180.28681580
113CDK11A0.28462079
114CDK150.28232902
115CAMK1G0.27204176
116AKT10.24230092
117CDK140.22677565
118MAPK10.22447053
119TYK20.22119968
120MAP3K30.21960349
121FGFR40.21840182
122FGFR10.21810235
123MAP4K10.20559185
124YES10.19919618
125DAPK10.18949073
126GSK3B0.18874122
127RPS6KB10.18353554
128ICK0.17950616

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49446592
2Mismatch repair_Homo sapiens_hsa034303.86433391
3One carbon pool by folate_Homo sapiens_hsa006703.39360182
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01897416
5Homologous recombination_Homo sapiens_hsa034402.64387422
6Base excision repair_Homo sapiens_hsa034102.64055802
7RNA transport_Homo sapiens_hsa030132.61634175
8Spliceosome_Homo sapiens_hsa030402.48097176
9Nucleotide excision repair_Homo sapiens_hsa034202.32598980
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30001008
11RNA polymerase_Homo sapiens_hsa030202.27988729
12Cell cycle_Homo sapiens_hsa041102.24935002
13Proteasome_Homo sapiens_hsa030502.20033224
14Pyrimidine metabolism_Homo sapiens_hsa002402.04004251
15Fanconi anemia pathway_Homo sapiens_hsa034602.00919525
16Ribosome_Homo sapiens_hsa030101.92939164
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91345312
18Selenocompound metabolism_Homo sapiens_hsa004501.82783645
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.77369576
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.73866560
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69812316
22Non-homologous end-joining_Homo sapiens_hsa034501.65464000
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.55496819
24Biosynthesis of amino acids_Homo sapiens_hsa012301.51842517
25Vitamin B6 metabolism_Homo sapiens_hsa007501.48779333
26Protein export_Homo sapiens_hsa030601.47848358
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47433543
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45635344
29Folate biosynthesis_Homo sapiens_hsa007901.41732804
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.38021801
31RNA degradation_Homo sapiens_hsa030181.36416696
32mRNA surveillance pathway_Homo sapiens_hsa030151.34461038
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33312577
34Systemic lupus erythematosus_Homo sapiens_hsa053221.31493657
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27606042
36Basal transcription factors_Homo sapiens_hsa030221.26058702
37p53 signaling pathway_Homo sapiens_hsa041151.23075256
38Arginine biosynthesis_Homo sapiens_hsa002201.16851786
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10942268
40Parkinsons disease_Homo sapiens_hsa050121.10608668
41Pentose phosphate pathway_Homo sapiens_hsa000301.07690545
42Oxidative phosphorylation_Homo sapiens_hsa001901.06637805
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05475352
44Carbon metabolism_Homo sapiens_hsa012001.03832025
45Huntingtons disease_Homo sapiens_hsa050161.03186603
46Tryptophan metabolism_Homo sapiens_hsa003800.98738270
47Nitrogen metabolism_Homo sapiens_hsa009100.91318412
48Purine metabolism_Homo sapiens_hsa002300.91025522
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90136979
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89895985
51Complement and coagulation cascades_Homo sapiens_hsa046100.89260181
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88737149
53Sulfur relay system_Homo sapiens_hsa041220.82789094
54Glutathione metabolism_Homo sapiens_hsa004800.82643200
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72878219
56Lysine degradation_Homo sapiens_hsa003100.72316502
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71611023
58Fatty acid degradation_Homo sapiens_hsa000710.71333721
59Epstein-Barr virus infection_Homo sapiens_hsa051690.71316418
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68581470
61Peroxisome_Homo sapiens_hsa041460.68107010
62Retinol metabolism_Homo sapiens_hsa008300.67273229
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67082571
64Chemical carcinogenesis_Homo sapiens_hsa052040.65734958
65Viral carcinogenesis_Homo sapiens_hsa052030.65617096
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64889038
67Caffeine metabolism_Homo sapiens_hsa002320.62160739
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60585239
69beta-Alanine metabolism_Homo sapiens_hsa004100.59647502
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.59511578
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59386509
72Fatty acid elongation_Homo sapiens_hsa000620.59276997
73Arginine and proline metabolism_Homo sapiens_hsa003300.58874640
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58718462
75Phenylalanine metabolism_Homo sapiens_hsa003600.58672026
76Alcoholism_Homo sapiens_hsa050340.56401350
77Herpes simplex infection_Homo sapiens_hsa051680.53542170
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53494413
79Tyrosine metabolism_Homo sapiens_hsa003500.52897472
80Oocyte meiosis_Homo sapiens_hsa041140.52297571
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51962692
82Pyruvate metabolism_Homo sapiens_hsa006200.51374657
83Fructose and mannose metabolism_Homo sapiens_hsa000510.51250954
84Histidine metabolism_Homo sapiens_hsa003400.50919213
85Alzheimers disease_Homo sapiens_hsa050100.50427005
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50130853
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45139326
88N-Glycan biosynthesis_Homo sapiens_hsa005100.43606038
89Antigen processing and presentation_Homo sapiens_hsa046120.42148226
90Vitamin digestion and absorption_Homo sapiens_hsa049770.41754572
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41652211
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41560926
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41059186
94Staphylococcus aureus infection_Homo sapiens_hsa051500.40790090
95Metabolic pathways_Homo sapiens_hsa011000.37909377
96Propanoate metabolism_Homo sapiens_hsa006400.37782950
97Hippo signaling pathway_Homo sapiens_hsa043900.37767025
98MicroRNAs in cancer_Homo sapiens_hsa052060.37537491
99Fat digestion and absorption_Homo sapiens_hsa049750.37042359
100TGF-beta signaling pathway_Homo sapiens_hsa043500.37007362
101HTLV-I infection_Homo sapiens_hsa051660.33327723
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32002800
103Fatty acid metabolism_Homo sapiens_hsa012120.31819522
104Galactose metabolism_Homo sapiens_hsa000520.31490971
105Hedgehog signaling pathway_Homo sapiens_hsa043400.29669876
106Butanoate metabolism_Homo sapiens_hsa006500.29604642
107Thyroid cancer_Homo sapiens_hsa052160.29301878
108Wnt signaling pathway_Homo sapiens_hsa043100.28792197
109PPAR signaling pathway_Homo sapiens_hsa033200.28605864
110Starch and sucrose metabolism_Homo sapiens_hsa005000.27224679
111Bladder cancer_Homo sapiens_hsa052190.26300898
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25993355
113Steroid biosynthesis_Homo sapiens_hsa001000.25763883
114Legionellosis_Homo sapiens_hsa051340.24749783
115Small cell lung cancer_Homo sapiens_hsa052220.23706158
116Prostate cancer_Homo sapiens_hsa052150.22604949
117Colorectal cancer_Homo sapiens_hsa052100.18688952
118Melanoma_Homo sapiens_hsa052180.17501910
119Apoptosis_Homo sapiens_hsa042100.14997550
120Basal cell carcinoma_Homo sapiens_hsa052170.13366484
121Adherens junction_Homo sapiens_hsa045200.12553857
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.12406076
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12304928
124Cardiac muscle contraction_Homo sapiens_hsa042600.07165529
125Chronic myeloid leukemia_Homo sapiens_hsa052200.05021450
126Pancreatic cancer_Homo sapiens_hsa052120.03296737
127Pathways in cancer_Homo sapiens_hsa052000.03292974
128Phototransduction_Homo sapiens_hsa047440.02741676

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