MCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)4.60784231
2detection of molecule of bacterial origin (GO:0032490)4.56007908
3positive regulation of gamma-delta T cell activation (GO:0046645)4.39039705
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38033991
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28127918
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.28127918
7modulation by symbiont of host immune response (GO:0052553)4.28127918
8positive regulation by symbiont of host defense response (GO:0052509)4.28127918
9modulation by symbiont of host defense response (GO:0052031)4.28127918
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28127918
11detection of bacterium (GO:0016045)4.20408259
12detection of external biotic stimulus (GO:0098581)4.15339835
13negative regulation of erythrocyte differentiation (GO:0045647)4.04331457
14antigen processing and presentation of endogenous antigen (GO:0019883)4.00813030
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92227740
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92227740
17regulation of interferon-beta biosynthetic process (GO:0045357)3.85299888
18detection of biotic stimulus (GO:0009595)3.81014946
19negative regulation of lymphocyte mediated immunity (GO:0002707)3.69052149
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.60979023
21positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.60472862
22neutrophil mediated immunity (GO:0002446)3.54683628
23regulation of gamma-delta T cell differentiation (GO:0045586)3.51532154
24NIK/NF-kappaB signaling (GO:0038061)3.45190494
25response to muramyl dipeptide (GO:0032495)3.43889419
26regulation of gamma-delta T cell activation (GO:0046643)3.41953034
27positive regulation of interferon-alpha production (GO:0032727)3.41356831
28negative regulation of T cell mediated immunity (GO:0002710)3.39760042
29negative regulation of cell killing (GO:0031342)3.36967018
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36967018
31macrophage activation involved in immune response (GO:0002281)3.36715671
32positive thymic T cell selection (GO:0045059)3.29555937
33regulation of B cell receptor signaling pathway (GO:0050855)3.27726496
34negative regulation of leukocyte mediated immunity (GO:0002704)3.26712882
35regulation of interferon-alpha production (GO:0032647)3.25752490
36immunoglobulin mediated immune response (GO:0016064)3.23294813
37regulation of mast cell degranulation (GO:0043304)3.22962264
38positive regulation of B cell differentiation (GO:0045579)3.20967182
39regulation of tolerance induction (GO:0002643)3.12863976
40antigen processing and presentation via MHC class Ib (GO:0002475)3.11083593
41leukocyte migration involved in inflammatory response (GO:0002523)3.07502215
42regulation of leukocyte degranulation (GO:0043300)3.06540711
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05417856
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02931218
45production of molecular mediator involved in inflammatory response (GO:0002532)3.02660087
46neutrophil activation involved in immune response (GO:0002283)3.01408636
47pinocytosis (GO:0006907)2.98982597
48regulation of mast cell activation involved in immune response (GO:0033006)2.98193743
49response to laminar fluid shear stress (GO:0034616)2.95470112
50defense response to protozoan (GO:0042832)2.94879891
51myeloid leukocyte mediated immunity (GO:0002444)2.94569816
52positive regulation of mast cell activation (GO:0033005)2.94020660
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.92815917
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92076183
55regulation of T-helper 2 cell differentiation (GO:0045628)2.90806272
56embryonic process involved in female pregnancy (GO:0060136)2.89117551
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88531474
58positive regulation of interferon-beta production (GO:0032728)2.84864168
59T cell migration (GO:0072678)2.84830660
60natural killer cell mediated cytotoxicity (GO:0042267)2.83779737
61natural killer cell mediated immunity (GO:0002228)2.83779737
62regulation of mast cell activation (GO:0033003)2.78546954
63positive regulation of cellular amide metabolic process (GO:0034250)2.78171263
64negative regulation of interleukin-12 production (GO:0032695)2.77539561
65regulation of cholesterol storage (GO:0010885)2.76723656
66regulation of B cell differentiation (GO:0045577)2.75897766
67T cell selection (GO:0045058)2.75188986
68regulation of macrophage cytokine production (GO:0010935)2.75037002
69B cell receptor signaling pathway (GO:0050853)2.74953215
70response to peptidoglycan (GO:0032494)2.72632572
71leukocyte aggregation (GO:0070486)2.72048438
72I-kappaB phosphorylation (GO:0007252)2.71277950
73B cell mediated immunity (GO:0019724)2.71274933
74response to protozoan (GO:0001562)2.71098969
75regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70610677
76positive regulation of antigen processing and presentation (GO:0002579)2.70183676
77negative regulation of type 2 immune response (GO:0002829)2.69643086
78negative regulation of toll-like receptor signaling pathway (GO:0034122)2.68805942
79neutrophil activation (GO:0042119)2.68606652
80negative regulation of T-helper cell differentiation (GO:0045623)2.68020737
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68020737
82negative regulation of B cell proliferation (GO:0030889)2.66257854
83T-helper 1 type immune response (GO:0042088)2.65978581
84hepatocyte apoptotic process (GO:0097284)2.65673523
85cellular response to interleukin-15 (GO:0071350)2.65084988
86cytokine secretion (GO:0050663)2.64313757
87granulocyte activation (GO:0036230)2.63096478
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62984961
89response to host immune response (GO:0052572)2.62984961
90regulation of T cell tolerance induction (GO:0002664)2.60671547
91growth hormone receptor signaling pathway (GO:0060396)2.54987731
92interferon-gamma-mediated signaling pathway (GO:0060333)2.54516643
93regulation of response to interferon-gamma (GO:0060330)2.54122837
94positive regulation of histone deacetylation (GO:0031065)2.53112308
95germinal center formation (GO:0002467)2.52439975
96response to host (GO:0075136)2.52238282
97response to host defenses (GO:0052200)2.52238282
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52238282
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52068391
100myeloid dendritic cell activation (GO:0001773)2.51469861
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50902767
102negative regulation of granulocyte differentiation (GO:0030853)2.50887079
103negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50394241
104B cell homeostasis (GO:0001782)2.50355732
105cellular extravasation (GO:0045123)2.49349322
106endothelial tube morphogenesis (GO:0061154)2.47235060
107morphogenesis of an endothelium (GO:0003159)2.47235060
108regulation of integrin activation (GO:0033623)2.46198026
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44666407
110myeloid dendritic cell differentiation (GO:0043011)2.43192455
111negative thymic T cell selection (GO:0045060)2.42562724
112leukocyte cell-cell adhesion (GO:0007159)2.42155804
113positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41850169
114cytoplasmic mRNA processing body assembly (GO:0033962)2.41360279
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39864547
116regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.39223256
117thymic T cell selection (GO:0045061)2.38906889
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.38209241
119microglial cell activation (GO:0001774)2.35178900
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34296377
121response to type I interferon (GO:0034340)2.34196307
122tolerance induction (GO:0002507)2.33592950
123positive regulation of p38MAPK cascade (GO:1900745)2.33482520
124respiratory burst (GO:0045730)2.33166592
125regulation of interferon-beta production (GO:0032648)2.32239554
126negative T cell selection (GO:0043383)2.31617536
127positive regulation of protein import into nucleus, translocation (GO:0033160)2.31545789
128nuclear pore complex assembly (GO:0051292)2.30909046
129cell adhesion mediated by integrin (GO:0033627)2.30150558
130myeloid cell activation involved in immune response (GO:0002275)2.29902766
131cellular response to type I interferon (GO:0071357)2.29161949
132type I interferon signaling pathway (GO:0060337)2.29161949
133natural killer cell differentiation (GO:0001779)2.26986911
134response to interleukin-15 (GO:0070672)2.26981428
135regulation of necroptotic process (GO:0060544)2.25943923
136macrophage activation (GO:0042116)2.25314132
137negative regulation of interleukin-6 production (GO:0032715)2.24857531
138lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24777661
139positive T cell selection (GO:0043368)2.24631657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.91637447
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.86407622
3E2F7_22180533_ChIP-Seq_HELA_Human3.79470053
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77584960
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61109664
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.54625530
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22686490
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.88753587
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86711140
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.86144373
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75052986
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51468291
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50420109
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.46864650
15MYC_22102868_ChIP-Seq_BL_Human2.44183497
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42989677
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42736038
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.26883007
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12159216
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11488054
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10855200
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10513198
23RUNX_20019798_ChIP-Seq_JUKART_Human2.08024053
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06932015
25* MAF_26560356_Chip-Seq_TH1_Human2.05831097
26MYB_26560356_Chip-Seq_TH2_Human1.97983336
27VDR_21846776_ChIP-Seq_THP-1_Human1.96934060
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94867713
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.91543920
30MYB_26560356_Chip-Seq_TH1_Human1.79955029
31SCL_19346495_ChIP-Seq_HPC-7_Human1.79265921
32* SMAD_19615063_ChIP-ChIP_OVARY_Human1.79003985
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78932909
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74679551
35* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68718905
36* SPI1_23547873_ChIP-Seq_NB4_Human1.65597651
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.64788817
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.63418685
39VDR_24763502_ChIP-Seq_THP-1_Human1.60410309
40* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59735443
41* UTX_26944678_Chip-Seq_JUKART_Human1.58179024
42* KDM2B_26808549_Chip-Seq_DND41_Human1.52051158
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51771700
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51506615
45* SPI1_23127762_ChIP-Seq_K562_Human1.48551259
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46666656
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46565240
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45708082
49* CLOCK_20551151_ChIP-Seq_293T_Human1.44313050
50PU_27001747_Chip-Seq_BMDM_Mouse1.41752043
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38701138
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.33630634
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31789849
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31517924
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.30930156
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29218228
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27446074
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26761192
59GATA1_19941826_ChIP-Seq_K562_Human1.22880824
60TFEB_21752829_ChIP-Seq_HELA_Human1.22203955
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20881199
62GATA3_27048872_Chip-Seq_THYMUS_Human1.19494099
63* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16559162
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14051520
65GATA1_22025678_ChIP-Seq_K562_Human1.12947048
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12280698
67* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12163970
68* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11230547
69* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11230547
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10948632
71NCOR1_26117541_ChIP-Seq_K562_Human1.10376704
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09622781
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09314674
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08794830
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.08529101
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07845444
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07354691
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06528606
79* MAF_26560356_Chip-Seq_TH2_Human1.06250489
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06021838
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05942358
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05704525
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05330805
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05330805
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05330805
86* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05006070
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04905956
88LXR_22292898_ChIP-Seq_THP-1_Human1.04066531
89GATA2_19941826_ChIP-Seq_K562_Human1.01271479
90KDM2B_26808549_Chip-Seq_K562_Human1.00227517
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00079268
92* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99241163
93VDR_24787735_ChIP-Seq_THP-1_Human0.98718224
94E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98668288
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98480979
96* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97600796
97GATA6_25053715_ChIP-Seq_YYC3_Human0.97577807
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97350496
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96322924
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96265532
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96115326
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96100446
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95471950
104RACK7_27058665_Chip-Seq_MCF-7_Human0.94810458
105* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93805558
106* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93546539
107GATA3_26560356_Chip-Seq_TH2_Human0.92698970
108* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92361909
109ATF3_27146783_Chip-Seq_COLON_Human0.91942487
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90083222
111* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90016406
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89341342
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88941036
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88933439
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.88845278
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.88323517
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88277664
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.86708599
119ZNF263_19887448_ChIP-Seq_K562_Human0.85890879
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85873549
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85027699
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83603753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.26995369
2MP0003303_peritoneal_inflammation3.15318413
3MP0003436_decreased_susceptibility_to2.54319661
4MP0000685_abnormal_immune_system2.52304120
5* MP0001800_abnormal_humoral_immune2.48425484
6MP0001790_abnormal_immune_system2.40988662
7MP0005387_immune_system_phenotype2.40988662
8MP0010352_gastrointestinal_tract_polyps2.33562929
9MP0003300_gastrointestinal_ulcer2.32142352
10* MP0002452_abnormal_antigen_presenting2.27446264
11MP0008260_abnormal_autophagy2.21839650
12MP0005000_abnormal_immune_tolerance2.15563186
13MP0005076_abnormal_cell_differentiation2.11610161
14MP0002419_abnormal_innate_immunity2.05377045
15MP0009278_abnormal_bone_marrow2.00694772
16* MP0002723_abnormal_immune_serum2.00465579
17MP0004510_myositis1.98537662
18MP0003705_abnormal_hypodermis_morpholog1.96859665
19MP0004947_skin_inflammation1.95013966
20MP0002166_altered_tumor_susceptibility1.94466430
21MP0005025_abnormal_response_to1.91457912
22MP0003566_abnormal_cell_adhesion1.91239110
23* MP0001819_abnormal_immune_cell1.89545887
24* MP0002420_abnormal_adaptive_immunity1.89477444
25MP0005451_abnormal_body_composition1.80001775
26MP0002148_abnormal_hypersensitivity_rea1.76121526
27MP0005671_abnormal_response_to1.75478207
28MP0009785_altered_susceptibility_to1.74854409
29MP0010307_abnormal_tumor_latency1.71827542
30MP0005058_abnormal_lysosome_morphology1.70354638
31MP0006082_CNS_inflammation1.69845872
32MP0003724_increased_susceptibility_to1.69561612
33MP0010155_abnormal_intestine_physiology1.68476975
34MP0002405_respiratory_system_inflammati1.68034181
35MP0000569_abnormal_digit_pigmentation1.67976123
36MP0002396_abnormal_hematopoietic_system1.67018027
37* MP0002398_abnormal_bone_marrow1.66914823
38MP0003448_altered_tumor_morphology1.61131990
39MP0002006_tumorigenesis1.59464811
40MP0005464_abnormal_platelet_physiology1.58577824
41MP0004883_abnormal_blood_vessel1.55505475
42* MP0000716_abnormal_immune_system1.54977746
43MP0002254_reproductive_system_inflammat1.54500344
44MP0002138_abnormal_hepatobiliary_system1.51166518
45MP0003191_abnormal_cellular_cholesterol1.49316297
46MP0004808_abnormal_hematopoietic_stem1.48655740
47MP0001853_heart_inflammation1.48207139
48MP0004185_abnormal_adipocyte_glucose1.46470500
49MP0000689_abnormal_spleen_morphology1.45294261
50MP0001845_abnormal_inflammatory_respons1.42839829
51MP0005397_hematopoietic_system_phenotyp1.39799932
52MP0001545_abnormal_hematopoietic_system1.39799932
53MP0001533_abnormal_skeleton_physiology1.38483918
54MP0001873_stomach_inflammation1.37372705
55MP0005164_abnormal_response_to1.36770487
56MP0002132_abnormal_respiratory_system1.36646980
57MP0010234_abnormal_vibrissa_follicle1.35293022
58MP0003763_abnormal_thymus_physiology1.34352379
59* MP0002722_abnormal_immune_system1.34110343
60* MP0002429_abnormal_blood_cell1.32939153
61MP0003828_pulmonary_edema1.32510913
62MP0003453_abnormal_keratinocyte_physiol1.32475233
63MP0000858_altered_metastatic_potential1.31675136
64MP0003866_abnormal_defecation1.27152061
65MP0001851_eye_inflammation1.22539436
66MP0003075_altered_response_to1.21858050
67MP0009840_abnormal_foam_cell1.21073713
68MP0005023_abnormal_wound_healing1.19275313
69MP0004381_abnormal_hair_follicle1.18700751
70MP0003656_abnormal_erythrocyte_physiolo1.17167702
71MP0003091_abnormal_cell_migration1.14369105
72MP0008004_abnormal_stomach_pH1.13624657
73MP0009333_abnormal_splenocyte_physiolog1.12208040
74* MP0000703_abnormal_thymus_morphology1.05078173
75MP0000490_abnormal_crypts_of1.04321537
76MP0003690_abnormal_glial_cell1.03362462
77MP0003183_abnormal_peptide_metabolism1.02387626
78MP0008469_abnormal_protein_level1.02303558
79MP0000465_gastrointestinal_hemorrhage1.02164037
80MP0005310_abnormal_salivary_gland1.01462158
81MP0003172_abnormal_lysosome_physiology1.00449085
82MP0000343_altered_response_to1.00394008
83MP0000767_abnormal_smooth_muscle0.98811478
84MP0003221_abnormal_cardiomyocyte_apopto0.96042798
85MP0002877_abnormal_melanocyte_morpholog0.95836207
86MP0002998_abnormal_bone_remodeling0.94721663
87MP0000371_diluted_coat_color0.94050924
88MP0000733_abnormal_muscle_development0.93638711
89MP0005167_abnormal_blood-brain_barrier0.92630870
90MP0001879_abnormal_lymphatic_vessel0.90126934
91MP0003045_fibrosis0.88843189
92MP0002933_joint_inflammation0.86134749
93MP0001958_emphysema0.82992833
94MP0002019_abnormal_tumor_incidence0.81977683
95MP0009763_increased_sensitivity_to0.81731042
96MP0002009_preneoplasia0.81529106
97MP0001915_intracranial_hemorrhage0.81524507
98MP0000604_amyloidosis0.80224834
99MP0008961_abnormal_basal_metabolism0.78222102
100MP0004264_abnormal_extraembryonic_tissu0.77684183
101MP0005409_darkened_coat_color0.77025582
102MP0000350_abnormal_cell_proliferation0.76836103
103MP0003077_abnormal_cell_cycle0.75891860
104MP0006054_spinal_hemorrhage0.75885876
105MP0005666_abnormal_adipose_tissue0.75212114
106MP0009764_decreased_sensitivity_to0.75100125
107MP0003795_abnormal_bone_structure0.74869196
108MP0005257_abnormal_intraocular_pressure0.74002176
109MP0002133_abnormal_respiratory_system0.72837023
110MP0005388_respiratory_system_phenotype0.72837023
111* MP0002086_abnormal_extraembryonic_tissu0.72777581
112MP0000249_abnormal_blood_vessel0.72591537
113MP0001216_abnormal_epidermal_layer0.72042901
114MP0003279_aneurysm0.72038724
115MP0008438_abnormal_cutaneous_collagen0.71630736
116MP0000609_abnormal_liver_physiology0.69544074
117MP0005390_skeleton_phenotype0.69538565
118MP0002136_abnormal_kidney_physiology0.69495256
119MP0002332_abnormal_exercise_endurance0.69290913
120MP0005166_decreased_susceptibility_to0.68725797
121MP0004130_abnormal_muscle_cell0.67311425
122MP0002277_abnormal_respiratory_mucosa0.65007133
123MP0005621_abnormal_cell_physiology0.64785084
124MP0009765_abnormal_xenobiotic_induced0.64533628

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.64142251
2Recurrent abscess formation (HP:0002722)4.57221911
3Recurrent bacterial skin infections (HP:0005406)4.24407916
4Gastrointestinal infarctions (HP:0005244)3.76932058
5Hematochezia (HP:0002573)3.66022720
6Recurrent fungal infections (HP:0002841)3.34312380
7Keratoconjunctivitis sicca (HP:0001097)3.34167237
8Recurrent gram-negative bacterial infections (HP:0005420)3.33161483
9Recurrent viral infections (HP:0004429)3.29779555
10Cellulitis (HP:0100658)3.13638542
11Disinhibition (HP:0000734)3.11529910
12Mediastinal lymphadenopathy (HP:0100721)3.10343396
13Colitis (HP:0002583)3.03242928
14Increased cerebral lipofuscin (HP:0011813)3.00588036
15Pustule (HP:0200039)2.98163288
16Keratoconjunctivitis (HP:0001096)2.97822095
17Myositis (HP:0100614)2.95978426
18Myocardial infarction (HP:0001658)2.93581681
19Amyloidosis (HP:0011034)2.93469172
20Abnormality of macrophages (HP:0004311)2.89627837
21Encephalitis (HP:0002383)2.89236880
22Autoimmune thrombocytopenia (HP:0001973)2.82547117
23Elevated erythrocyte sedimentation rate (HP:0003565)2.81923659
24Peritonitis (HP:0002586)2.78803505
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76945203
26Recurrent skin infections (HP:0001581)2.74875187
27Spontaneous hematomas (HP:0007420)2.73285928
28Interstitial pulmonary disease (HP:0006530)2.69081351
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.68015548
30Osteolytic defects of the hand bones (HP:0009699)2.68015548
31Hemoptysis (HP:0002105)2.67371837
32Prolonged bleeding time (HP:0003010)2.67252117
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.61888082
34Cerebral aneurysm (HP:0004944)2.60568500
35Gingivitis (HP:0000230)2.57394388
36Nasal polyposis (HP:0100582)2.56086308
37Periodontitis (HP:0000704)2.55867942
38Abnormality of the nasal mucosa (HP:0000433)2.55457816
39Inflammation of the large intestine (HP:0002037)2.54949755
40Epistaxis (HP:0000421)2.45841100
41Stomatitis (HP:0010280)2.42251463
42Episodic fever (HP:0001954)2.42084804
43Gastrointestinal inflammation (HP:0004386)2.41344376
44Orchitis (HP:0100796)2.38852003
45Chronic otitis media (HP:0000389)2.34344875
46Recurrent bronchitis (HP:0002837)2.33841476
47Agammaglobulinemia (HP:0004432)2.33283951
48Osteomyelitis (HP:0002754)2.33186815
49Recurrent cutaneous fungal infections (HP:0011370)2.32671481
50Chronic mucocutaneous candidiasis (HP:0002728)2.32671481
51Systemic lupus erythematosus (HP:0002725)2.32371403
52Vasculitis (HP:0002633)2.28517247
53Pulmonary embolism (HP:0002204)2.28049807
54Abnormality of the peritoneum (HP:0002585)2.25603031
55Esophageal varix (HP:0002040)2.24990027
56Thick nail (HP:0001805)2.24003838
57Abnormality of the fingertips (HP:0001211)2.21310929
58Arterial thrombosis (HP:0004420)2.20465196
59Emphysema (HP:0002097)2.18838572
60Slow saccadic eye movements (HP:0000514)2.18423022
61Granulocytopenia (HP:0001913)2.17957324
62Chronic obstructive pulmonary disease (HP:0006510)2.16331116
63Obstructive lung disease (HP:0006536)2.16331116
64Persistence of primary teeth (HP:0006335)2.12812210
65Gastrointestinal stroma tumor (HP:0100723)2.11435376
66Gangrene (HP:0100758)2.11390570
67Meningitis (HP:0001287)2.11015144
68Increased IgE level (HP:0003212)2.10101673
69Prostate neoplasm (HP:0100787)2.09976999
70Anorexia (HP:0002039)2.08664819
71Agnosia (HP:0010524)2.07411459
72Glomerulopathy (HP:0100820)2.07349549
73Vacuolated lymphocytes (HP:0001922)2.07322444
74Papilloma (HP:0012740)2.06879840
75Verrucae (HP:0200043)2.06879840
76IgM deficiency (HP:0002850)2.05468733
77Leukocytosis (HP:0001974)2.04234848
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.03903601
79Fatigue (HP:0012378)1.99142313
80Syringomyelia (HP:0003396)1.98650272
81Spinal cord lesions (HP:0100561)1.98650272
82Retrobulbar optic neuritis (HP:0100654)1.96998391
83Optic neuritis (HP:0100653)1.96998391
84Abnormality of the endocardium (HP:0004306)1.96245809
85Segmental peripheral demyelination/remyelination (HP:0003481)1.95864211
86Abnormality of the pleura (HP:0002103)1.94283530
87Sepsis (HP:0100806)1.93466152
88Abnormality of T cell physiology (HP:0011840)1.92452318
89Aortic aneurysm (HP:0004942)1.92345218
90Abnormality of T cell number (HP:0011839)1.91821473
91T lymphocytopenia (HP:0005403)1.91081684
92Hypochromic anemia (HP:0001931)1.88818409
93Hypergammaglobulinemia (HP:0010702)1.87181942
94Eosinophilia (HP:0001880)1.87132038
95Subacute progressive viral hepatitis (HP:0006572)1.85589416
96Large earlobe (HP:0009748)1.85347760
97Pulmonary infiltrates (HP:0002113)1.84200755
98Viral hepatitis (HP:0006562)1.82701279
99Gingival bleeding (HP:0000225)1.82446829
100Abnormal platelet volume (HP:0011876)1.82038956
101Polycythemia (HP:0001901)1.81294542
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80567687
103Glomerulonephritis (HP:0000099)1.80040699
104Skin ulcer (HP:0200042)1.79860240
105Cheilitis (HP:0100825)1.79237441
106Urticaria (HP:0001025)1.78946452
107Polygenic inheritance (HP:0010982)1.78609732
108Dilatation of the ascending aorta (HP:0005111)1.78290400
109Mitral valve prolapse (HP:0001634)1.76648827
110Panhypogammaglobulinemia (HP:0003139)1.76084352
111Thrombocytosis (HP:0001894)1.74203697
112Dysostosis multiplex (HP:0000943)1.72966137
113Frequent falls (HP:0002359)1.72087296
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.72077109
115Lymphopenia (HP:0001888)1.71978786
116Increased IgM level (HP:0003496)1.71898028
117Abnormality of T cells (HP:0002843)1.71558791
118Porencephaly (HP:0002132)1.71502287
119Amaurosis fugax (HP:0100576)1.71274226
120Absent frontal sinuses (HP:0002688)1.69940980
121Premature loss of primary teeth (HP:0006323)1.69525245
122Hypochromic microcytic anemia (HP:0004840)1.69133846
123Metaphyseal cupping (HP:0003021)1.66437966
124Bicuspid aortic valve (HP:0001647)1.65862633
125Increased serum ferritin (HP:0003281)1.65724511
126Loss of speech (HP:0002371)1.65536273
127Restrictive lung disease (HP:0002091)1.65378465
128IgA deficiency (HP:0002720)1.65248942
129Striae distensae (HP:0001065)1.64823814
130Malignant gastrointestinal tract tumors (HP:0006749)1.64786413
131Gastrointestinal carcinoma (HP:0002672)1.64786413
132Increased density of long bones (HP:0006392)1.63339365
133Spondylolisthesis (HP:0003302)1.63114701
134Nephritis (HP:0000123)1.62649208
135Ulnar bowing (HP:0003031)1.62454854
136Chest pain (HP:0100749)1.62234945
137Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61025834
138Conjunctival telangiectasia (HP:0000524)1.60885554
139Autoimmune hemolytic anemia (HP:0001890)1.57849845
140Mucopolysacchariduria (HP:0008155)1.57482965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.62425320
2MAP4K13.02550451
3TYK22.69582380
4MAP3K142.61227626
5CDK122.44658178
6STK102.36690291
7MAP3K102.34436140
8TGFBR22.30689855
9TBK12.16217638
10TRIB32.14777652
11ERN12.01958444
12IKBKB2.00550918
13JAK32.00533716
14FES1.97040863
15PKN21.94988627
16BLK1.74074495
17FGFR41.71608536
18PTK61.65517609
19IKBKE1.63875069
20EPHB11.61263950
21JAK11.61114131
22ZAP701.59348892
23TTN1.58875860
24DMPK1.58030248
25FGFR31.53110169
26CSK1.51472422
27RPS6KA41.51270099
28IRAK41.49283369
29RIPK11.47513082
30MAP2K31.44897956
31IRAK11.44169411
32CSF1R1.40761484
33LRRK21.40395162
34CHUK1.40365793
35BMPR21.38394662
36ITK1.35898631
37RIPK41.34851321
38MAP3K11.33829661
39KSR21.33155710
40FLT31.32895405
41KIT1.32586157
42PIM11.31654393
43CDK61.29567346
44MAP3K131.27096787
45YES11.25960564
46EEF2K1.25916799
47IRAK21.25550422
48GRK61.22856273
49MAP3K31.20033401
50TNK21.18098777
51HCK1.17097174
52MAP3K61.12083244
53CAMK1D1.11995667
54MARK21.10159375
55IRAK31.08658448
56SIK31.07832472
57PAK41.05586350
58EPHA31.05464767
59MAPK71.04231823
60NEK91.03735770
61MARK31.02810801
62STK31.00476962
63ALK0.98169417
64BTK0.97883921
65STK40.97072062
66JAK20.96925284
67TAOK20.95301166
68NEK20.92204430
69MAP3K20.91895840
70LCK0.91149109
71TXK0.90259837
72CDK90.89151572
73SMG10.87475249
74CDK40.85031456
75SYK0.82910899
76EPHA20.81352726
77PDGFRB0.79919964
78PIK3CG0.79404450
79PDK10.79066965
80PDPK10.78463213
81MAP3K110.78301051
82MAP3K70.76360983
83PRKD20.76155581
84CDC42BPA0.75929944
85SGK30.75020859
86BMX0.73618168
87TEC0.71651676
88SCYL20.71608998
89MAP3K80.71305833
90MAPK120.70912651
91MST40.68513955
92CAMK1G0.66630198
93TAOK30.65333913
94MOS0.64845887
95BRD40.64120786
96NLK0.63716273
97FGR0.63420622
98EGFR0.62634211
99MELK0.61211721
100RET0.60471803
101NME20.59705632
102RPS6KC10.59430960
103RPS6KL10.59430960
104MAP3K50.58666417
105MAP2K20.56244221
106LATS10.55959791
107DYRK1B0.55119011
108TGFBR10.53742989
109SGK20.52735288
110RPS6KB20.52051063
111LYN0.51747523
112* MTOR0.49641038
113KSR10.48875600
114WNK10.48146015
115NUAK10.47818333
116MAPKAPK20.47518789
117RAF10.47498392
118FYN0.46476037
119TRPM70.45952438
120ABL10.45916105
121SIK20.45782263
122RPS6KA60.45776684
123ICK0.42346288
124MAPK150.42282416
125MATK0.40963217
126PDGFRA0.40607285
127TAOK10.40275225
128PAK20.39152332
129HIPK20.37592564
130SIK10.37110026
131* GSK3A0.36558566
132CLK10.35831782
133STK240.34661313
134RPS6KA50.34100058
135INSR0.33692283
136PRKAA20.33688399

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.62115719
2Osteoclast differentiation_Homo sapiens_hsa043802.53514650
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.52445774
4B cell receptor signaling pathway_Homo sapiens_hsa046622.41992612
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11412550
6Antigen processing and presentation_Homo sapiens_hsa046122.06003777
7Staphylococcus aureus infection_Homo sapiens_hsa051501.99834277
8Measles_Homo sapiens_hsa051621.88865938
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86199104
10Toxoplasmosis_Homo sapiens_hsa051451.83848180
11TNF signaling pathway_Homo sapiens_hsa046681.76604346
12Primary immunodeficiency_Homo sapiens_hsa053401.73508989
13Legionellosis_Homo sapiens_hsa051341.64449088
14Chronic myeloid leukemia_Homo sapiens_hsa052201.58964466
15T cell receptor signaling pathway_Homo sapiens_hsa046601.57680431
16Herpes simplex infection_Homo sapiens_hsa051681.56400035
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55549640
18* Apoptosis_Homo sapiens_hsa042101.54771359
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.54465692
20Influenza A_Homo sapiens_hsa051641.53536056
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53397452
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53329269
23Tuberculosis_Homo sapiens_hsa051521.53181204
24Autoimmune thyroid disease_Homo sapiens_hsa053201.52091973
25Pertussis_Homo sapiens_hsa051331.49695649
26Small cell lung cancer_Homo sapiens_hsa052221.45350950
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.44510557
28Acute myeloid leukemia_Homo sapiens_hsa052211.42530536
29Hematopoietic cell lineage_Homo sapiens_hsa046401.41093095
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.39711233
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38947078
32Pancreatic cancer_Homo sapiens_hsa052121.37786644
33Malaria_Homo sapiens_hsa051441.37477711
34Hepatitis B_Homo sapiens_hsa051611.33835040
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30743750
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30212614
37* Jak-STAT signaling pathway_Homo sapiens_hsa046301.26960356
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26773979
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25542052
40Viral myocarditis_Homo sapiens_hsa054161.23814092
41Shigellosis_Homo sapiens_hsa051311.20821545
42Viral carcinogenesis_Homo sapiens_hsa052031.19211039
43Chemokine signaling pathway_Homo sapiens_hsa040621.19098661
44Lysosome_Homo sapiens_hsa041421.10904393
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09314356
46Type I diabetes mellitus_Homo sapiens_hsa049401.09082364
47Hepatitis C_Homo sapiens_hsa051601.08854980
48Graft-versus-host disease_Homo sapiens_hsa053321.05062442
49Proteoglycans in cancer_Homo sapiens_hsa052051.00355223
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.98829640
51* MicroRNAs in cancer_Homo sapiens_hsa052060.98296225
52Platelet activation_Homo sapiens_hsa046110.97341161
53Epstein-Barr virus infection_Homo sapiens_hsa051690.96727031
54Amoebiasis_Homo sapiens_hsa051460.92395376
55Salmonella infection_Homo sapiens_hsa051320.92318289
56Insulin resistance_Homo sapiens_hsa049310.92173157
57Notch signaling pathway_Homo sapiens_hsa043300.91773757
58Adherens junction_Homo sapiens_hsa045200.90235406
59HTLV-I infection_Homo sapiens_hsa051660.89419871
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89353660
61p53 signaling pathway_Homo sapiens_hsa041150.89024851
62Allograft rejection_Homo sapiens_hsa053300.87932115
63Prolactin signaling pathway_Homo sapiens_hsa049170.87529159
64Choline metabolism in cancer_Homo sapiens_hsa052310.84156176
65ErbB signaling pathway_Homo sapiens_hsa040120.83217764
66GnRH signaling pathway_Homo sapiens_hsa049120.82679959
67Caffeine metabolism_Homo sapiens_hsa002320.82065303
68mTOR signaling pathway_Homo sapiens_hsa041500.81982388
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81452631
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.80058140
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79751392
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.79221351
73Focal adhesion_Homo sapiens_hsa045100.79030489
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78940118
75Non-small cell lung cancer_Homo sapiens_hsa052230.78376487
76Other glycan degradation_Homo sapiens_hsa005110.78211798
77Colorectal cancer_Homo sapiens_hsa052100.76759109
78VEGF signaling pathway_Homo sapiens_hsa043700.73673951
79Prostate cancer_Homo sapiens_hsa052150.73493309
80Bladder cancer_Homo sapiens_hsa052190.73284877
81FoxO signaling pathway_Homo sapiens_hsa040680.72104026
82Renal cell carcinoma_Homo sapiens_hsa052110.71212183
83HIF-1 signaling pathway_Homo sapiens_hsa040660.70938374
84African trypanosomiasis_Homo sapiens_hsa051430.70778343
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69990196
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68901720
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65782517
88Dorso-ventral axis formation_Homo sapiens_hsa043200.64293833
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63860799
90Estrogen signaling pathway_Homo sapiens_hsa049150.63481560
91Glioma_Homo sapiens_hsa052140.62422277
92Lysine degradation_Homo sapiens_hsa003100.58472436
93Endometrial cancer_Homo sapiens_hsa052130.57707940
94Complement and coagulation cascades_Homo sapiens_hsa046100.56167138
95TGF-beta signaling pathway_Homo sapiens_hsa043500.55806712
96Phagosome_Homo sapiens_hsa041450.55412979
97Rheumatoid arthritis_Homo sapiens_hsa053230.54636902
98Asthma_Homo sapiens_hsa053100.54104108
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53631606
100Type II diabetes mellitus_Homo sapiens_hsa049300.53031815
101Insulin signaling pathway_Homo sapiens_hsa049100.52469631
102Pathways in cancer_Homo sapiens_hsa052000.52443030
103Systemic lupus erythematosus_Homo sapiens_hsa053220.52099087
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51856606
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51132792
106One carbon pool by folate_Homo sapiens_hsa006700.50615115
107Inositol phosphate metabolism_Homo sapiens_hsa005620.49738628
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49047702
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48599182
110Endocytosis_Homo sapiens_hsa041440.48285742
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45332908
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44357264
113ECM-receptor interaction_Homo sapiens_hsa045120.42653138
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41699950
115MAPK signaling pathway_Homo sapiens_hsa040100.41580456
116Thyroid cancer_Homo sapiens_hsa052160.41505170
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.41435503
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40806643

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