MCIDAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.86139178
2* centriole assembly (GO:0098534)6.54922217
3heterochromatin organization (GO:0070828)5.45621272
4energy homeostasis (GO:0097009)5.41084636
5nuclear pore complex assembly (GO:0051292)5.39628380
6regulation of translational termination (GO:0006449)4.78400067
7nuclear pore organization (GO:0006999)4.67418998
8mitotic chromosome condensation (GO:0007076)4.49835482
9protein K6-linked ubiquitination (GO:0085020)4.47183672
10superoxide anion generation (GO:0042554)4.46035076
11mitotic sister chromatid cohesion (GO:0007064)4.42140801
12DNA unwinding involved in DNA replication (GO:0006268)4.33371090
13regulation of DNA endoreduplication (GO:0032875)4.29583769
14keratinocyte proliferation (GO:0043616)4.28226852
15DNA replication initiation (GO:0006270)4.26995834
16detection of molecule of bacterial origin (GO:0032490)4.23337318
17regulation of activation of Janus kinase activity (GO:0010533)4.17794239
18axonemal dynein complex assembly (GO:0070286)4.13674336
19centriole replication (GO:0007099)4.09257641
20regulation of translational fidelity (GO:0006450)4.07831051
21* motile cilium assembly (GO:0044458)4.06254592
22pore complex assembly (GO:0046931)4.04097120
23regulation of centriole replication (GO:0046599)4.01111728
24hepatocyte differentiation (GO:0070365)3.98817231
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.90470169
26cilium or flagellum-dependent cell motility (GO:0001539)3.88004863
27positive regulation of DNA-dependent DNA replication (GO:2000105)3.83673451
28mitotic sister chromatid segregation (GO:0000070)3.79216352
29auditory receptor cell stereocilium organization (GO:0060088)3.78284907
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76690672
31DNA strand elongation involved in DNA replication (GO:0006271)3.75857101
32protein localization to chromosome, centromeric region (GO:0071459)3.75687092
33DNA strand elongation (GO:0022616)3.71810999
34telomere maintenance via semi-conservative replication (GO:0032201)3.70091670
35detection of other organism (GO:0098543)3.59989620
36detection of external biotic stimulus (GO:0098581)3.56076379
37detection of bacterium (GO:0016045)3.55660768
38DNA replication checkpoint (GO:0000076)3.55259131
39sister chromatid segregation (GO:0000819)3.47712305
40formation of translation preinitiation complex (GO:0001731)3.41243500
41DNA replication-dependent nucleosome organization (GO:0034723)3.39185970
42DNA replication-dependent nucleosome assembly (GO:0006335)3.39185970
43protein localization to kinetochore (GO:0034501)3.38113035
44Golgi transport vesicle coating (GO:0048200)3.33550354
45COPI coating of Golgi vesicle (GO:0048205)3.33550354
46positive regulation of cellular amide metabolic process (GO:0034250)3.33089891
47proline biosynthetic process (GO:0006561)3.32872148
48regulation of mitotic spindle organization (GO:0060236)3.30318944
49mitotic nuclear envelope disassembly (GO:0007077)3.28936596
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24677565
51negative regulation of mast cell activation (GO:0033004)3.22870795
52trophoblast giant cell differentiation (GO:0060707)3.22086531
53cellular anion homeostasis (GO:0030002)3.21228570
54regulation of centrosome cycle (GO:0046605)3.17435886
55DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16237409
56ribosome biogenesis (GO:0042254)3.14099566
57mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12083160
58mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12083160
59inner ear receptor stereocilium organization (GO:0060122)3.09740316
60embryonic process involved in female pregnancy (GO:0060136)3.09238258
61cilium movement (GO:0003341)3.08931120
62DNA duplex unwinding (GO:0032508)3.07580708
63oocyte maturation (GO:0001556)3.07004532
64nucleobase-containing small molecule interconversion (GO:0015949)3.06182500
65kidney morphogenesis (GO:0060993)3.06046319
66intraciliary transport (GO:0042073)3.05466674
67regulation of centrosome duplication (GO:0010824)3.04542814
68membrane disassembly (GO:0030397)3.04434695
69nuclear envelope disassembly (GO:0051081)3.04434695
70regulation of DNA-dependent DNA replication (GO:0090329)3.03631364
71chromosome condensation (GO:0030261)3.03339797
72sensory perception of smell (GO:0007608)3.03129371
73protein complex localization (GO:0031503)3.02227203
74telomere maintenance via recombination (GO:0000722)3.01903697
75meiotic chromosome segregation (GO:0045132)2.99591804
76dosage compensation (GO:0007549)2.99354000
77chromatin assembly (GO:0031497)2.98456867
78behavioral response to nicotine (GO:0035095)2.98274475
79microtubule depolymerization (GO:0007019)2.98182534
80detection of biotic stimulus (GO:0009595)2.98054189
81mitotic recombination (GO:0006312)2.97782519
82notochord development (GO:0030903)2.97194430
83DNA damage response, signal transduction resulting in transcription (GO:0042772)2.96225202
84viral mRNA export from host cell nucleus (GO:0046784)2.96185899
85establishment of integrated proviral latency (GO:0075713)2.95368476
86serotonin receptor signaling pathway (GO:0007210)2.94201353
87mitotic metaphase plate congression (GO:0007080)2.92391933
88adenine nucleotide transport (GO:0051503)2.92141983
89amino acid activation (GO:0043038)2.92011573
90tRNA aminoacylation (GO:0043039)2.92011573
91DNA geometric change (GO:0032392)2.90597996
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90159331
93response to pheromone (GO:0019236)2.89961719
94cellular protein complex localization (GO:0034629)2.89022989
95cyclooxygenase pathway (GO:0019371)2.88323150
96ribosome assembly (GO:0042255)2.88197770
97* cilium assembly (GO:0042384)2.87560387
98histamine secretion (GO:0001821)2.87439352
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86832613
100mitochondrial DNA metabolic process (GO:0032042)2.86452315
101folic acid metabolic process (GO:0046655)2.84858441
102histone H3-K9 methylation (GO:0051567)2.82289718
103regulation of spindle organization (GO:0090224)2.82030576
104positive regulation of chromosome segregation (GO:0051984)2.80240361
105positive regulation of uterine smooth muscle contraction (GO:0070474)2.80161925
106cell differentiation involved in metanephros development (GO:0072202)2.80083858
107DNA conformation change (GO:0071103)2.79143302
108regulation of interleukin-8 secretion (GO:2000482)2.77707876
109epithelial cilium movement (GO:0003351)2.76766671
110axoneme assembly (GO:0035082)2.76570602
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.73760056
112tRNA aminoacylation for protein translation (GO:0006418)2.73263610
113chromatin assembly or disassembly (GO:0006333)2.73203846
114nuclear envelope organization (GO:0006998)2.72063104
115spliceosomal tri-snRNP complex assembly (GO:0000244)2.71779477
116DNA packaging (GO:0006323)2.71565100
117limb bud formation (GO:0060174)2.70913707
118nucleotide transmembrane transport (GO:1901679)2.70829022
119negative regulation of organelle assembly (GO:1902116)2.69503801
120protein localization to microtubule (GO:0035372)2.69269620
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68548339
122pseudouridine synthesis (GO:0001522)2.68219390
123negative regulation of myoblast differentiation (GO:0045662)2.67731279
124cerebral cortex radially oriented cell migration (GO:0021799)2.67689447
125* cilium organization (GO:0044782)2.67343614
126DNA topological change (GO:0006265)2.65548170
127ribonucleoprotein complex biogenesis (GO:0022613)2.65475097
128DNA synthesis involved in DNA repair (GO:0000731)2.60537153
129chromatin remodeling at centromere (GO:0031055)2.60319699
130startle response (GO:0001964)2.60127504
131replicative senescence (GO:0090399)2.58520285
132peptidyl-histidine modification (GO:0018202)2.57737376
133tRNA methylation (GO:0030488)2.57733816
134purine ribonucleotide transport (GO:0015868)2.57307499
135transcription from mitochondrial promoter (GO:0006390)2.56072381
136centrosome duplication (GO:0051298)2.55182303
137regulation of translational elongation (GO:0006448)2.54984711
138cellular senescence (GO:0090398)2.53713972
139rRNA transcription (GO:0009303)2.53423317
140sister chromatid cohesion (GO:0007062)2.53173405
141diaphragm development (GO:0060539)2.50803614
142folic acid-containing compound biosynthetic process (GO:0009396)2.50521379
143desmosome organization (GO:0002934)2.50315241
144sulfate transmembrane transport (GO:1902358)2.49724403
145RNA-dependent DNA replication (GO:0006278)2.44336246
146extracellular negative regulation of signal transduction (GO:1900116)2.44207819
147extracellular regulation of signal transduction (GO:1900115)2.44207819
148regulation of timing of cell differentiation (GO:0048505)2.44184274
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43945275
150phosphate ion homeostasis (GO:0055062)2.42887780
151trivalent inorganic anion homeostasis (GO:0072506)2.42887780
152natural killer cell activation involved in immune response (GO:0002323)2.42720858
153ganglion development (GO:0061548)2.42073874
154inner ear receptor cell differentiation (GO:0060113)2.37167316
155developmental pigmentation (GO:0048066)2.36638942
156opioid receptor signaling pathway (GO:0038003)2.36357741
157one-carbon compound transport (GO:0019755)2.36302310
158retina layer formation (GO:0010842)2.35926857
159adenosine metabolic process (GO:0046085)2.34675906
160female gonad development (GO:0008585)2.33833074
161dentate gyrus development (GO:0021542)2.33633845
162forebrain neuron differentiation (GO:0021879)2.33307713
163dendritic cell chemotaxis (GO:0002407)2.32863899
164sulfate transport (GO:0008272)2.32400170
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31128423
166positive regulation of interleukin-1 beta secretion (GO:0050718)2.31022792
167positive regulation of antigen processing and presentation (GO:0002579)2.30522167
168superoxide metabolic process (GO:0006801)2.27784317
169regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27691806
170prostaglandin biosynthetic process (GO:0001516)2.24436324
171prostanoid biosynthetic process (GO:0046457)2.24436324
172positive regulation of CREB transcription factor activity (GO:0032793)2.24266658
173negative regulation of keratinocyte proliferation (GO:0010839)2.23274241
174G-protein coupled receptor internalization (GO:0002031)2.22987263
175regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.22627395
176positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.22627395
177dendritic cell migration (GO:0036336)2.22203440
178DNA integration (GO:0015074)2.21509700
179negative regulation of systemic arterial blood pressure (GO:0003085)2.21133639
180left/right axis specification (GO:0070986)2.19356130
181purine nucleotide transport (GO:0015865)2.19310300
182mechanoreceptor differentiation (GO:0042490)2.19163194
183cell proliferation involved in metanephros development (GO:0072203)2.18704296
184negative regulation of T cell mediated immunity (GO:0002710)2.18444396
185regulation of antigen processing and presentation (GO:0002577)2.17681201
186histamine transport (GO:0051608)2.16203449
187postsynaptic membrane organization (GO:0001941)2.16189201
188facial nerve structural organization (GO:0021612)2.15074230
189negative regulation of stem cell proliferation (GO:2000647)2.14905764
190righting reflex (GO:0060013)2.14778872
191neural tube formation (GO:0001841)2.14550933
192glycoside metabolic process (GO:0016137)2.13859522
193presynaptic membrane assembly (GO:0097105)2.13423597
194positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13106822
195doxorubicin metabolic process (GO:0044598)10.9594653
196daunorubicin metabolic process (GO:0044597)10.9594653
197polyketide metabolic process (GO:0030638)10.9594653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.49028938
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.71735925
3GBX2_23144817_ChIP-Seq_PC3_Human4.02906057
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.84764558
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44334470
6EZH2_22144423_ChIP-Seq_EOC_Human3.41589129
7ZNF263_19887448_ChIP-Seq_K562_Human3.18075197
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14195221
9AR_21909140_ChIP-Seq_LNCAP_Human3.05891759
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04277331
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96993379
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87368478
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78501510
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75871082
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61706219
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51993847
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49412298
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45045760
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40272417
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.39847595
21DCP1A_22483619_ChIP-Seq_HELA_Human2.34040726
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33824411
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.33045953
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26792535
25SUZ12_27294783_Chip-Seq_NPCs_Mouse2.23850013
26XRN2_22483619_ChIP-Seq_HELA_Human2.20831084
27NFE2_27457419_Chip-Seq_LIVER_Mouse2.11690505
28ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06820511
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06747447
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02237722
31TP63_17297297_ChIP-ChIP_HaCaT_Human2.01710696
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.01161448
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00366684
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99715314
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99399260
36P300_19829295_ChIP-Seq_ESCs_Human1.97764328
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97615680
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97458796
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.94888316
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93014342
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91628310
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.91068805
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89390980
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88520545
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.87662708
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87318850
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.86219229
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85563304
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85070413
50TTF2_22483619_ChIP-Seq_HELA_Human1.84305357
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83982109
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82670099
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82255606
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.82217699
55P53_22387025_ChIP-Seq_ESCs_Mouse1.81726375
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81270601
57TAF15_26573619_Chip-Seq_HEK293_Human1.79926452
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.78976594
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78056000
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.76662352
61RNF2_27304074_Chip-Seq_NSC_Mouse1.76501255
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73940163
63AR_21572438_ChIP-Seq_LNCaP_Human1.73735354
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.72916469
65GABP_19822575_ChIP-Seq_HepG2_Human1.72616842
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71399551
67KDM5A_27292631_Chip-Seq_BREAST_Human1.69533256
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69005063
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67028407
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.64774484
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64166982
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63615110
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.61001578
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60641172
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60571017
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59634681
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.58385299
78FUS_26573619_Chip-Seq_HEK293_Human1.57727021
79IGF1R_20145208_ChIP-Seq_DFB_Human1.57666982
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57642742
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56800307
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55082159
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54839694
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54478135
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54474133
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.54297462
87SMAD4_21799915_ChIP-Seq_A2780_Human1.54258375
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53736275
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.53710284
90P300_18555785_Chip-Seq_ESCs_Mouse1.53394935
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53179856
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49119264
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.49045162
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.48902979
95PU1_27457419_Chip-Seq_LIVER_Mouse1.48635560
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48299903
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47615816
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46334794
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.46274650
100ER_23166858_ChIP-Seq_MCF-7_Human1.45594339
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45108458
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45108458
103MYC_22102868_ChIP-Seq_BL_Human1.44728867
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.44421025
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.44399431
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44345137
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43368003
108EWS_26573619_Chip-Seq_HEK293_Human1.43206274
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.42667510
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42195172
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.39469870
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39419052
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39350579
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38651767
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38481073
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38204082
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37654011
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37531211
119ATF3_27146783_Chip-Seq_COLON_Human1.34857271
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.34528258
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34276226
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34103498
123ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33837827
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.32330392
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31309738
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31112677
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31112677
128VDR_22108803_ChIP-Seq_LS180_Human1.30450619
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29809966
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29563137
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29338903
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28907892
133TP53_18474530_ChIP-ChIP_U2OS_Human1.28332623
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26750745
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.26456931
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26386836
137IRF1_19129219_ChIP-ChIP_H3396_Human1.25149761
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25109770
139AR_25329375_ChIP-Seq_VCAP_Human1.24636052
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.23323725
141RACK7_27058665_Chip-Seq_MCF-7_Human1.23318741
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23305629
143JUN_21703547_ChIP-Seq_K562_Human1.23106607
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23014440
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22850486
146YY1_21170310_ChIP-Seq_MESCs_Mouse1.22735940
147STAT3_23295773_ChIP-Seq_U87_Human1.22496419
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22182711
149OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22078212
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21020625
151CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20898190
152RUNX2_22187159_ChIP-Seq_PCA_Human1.20838900
153CRX_20693478_ChIP-Seq_RETINA_Mouse1.20380006
154FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20280257
155TCF4_23295773_ChIP-Seq_U87_Human1.20181021
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19891320
157E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18280216
158NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16247558
159ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15560813
160GABP_17652178_ChIP-ChIP_JURKAT_Human1.15233030
161CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15074226
162MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14992643
163KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14944852
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14354381
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13856907
166CHD1_26751641_Chip-Seq_LNCaP_Human1.12871333
167REST_21632747_ChIP-Seq_MESCs_Mouse1.11892872
168SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10350210
169ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10211411
170NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05037553
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04648095
172ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04529243
173TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03975175
174EST1_17652178_ChIP-ChIP_JURKAT_Human1.02270481
175KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00029235
176SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98196190
177SOX17_20123909_ChIP-Seq_XEN_Mouse0.98014428
178PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97945013
179TFEB_21752829_ChIP-Seq_HELA_Human0.97019232
180TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96754848
181VDR_23849224_ChIP-Seq_CD4+_Human0.93471240
182FOXP3_21729870_ChIP-Seq_TREG_Human0.92996202
183PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92731544
184BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89274714
185TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89229047
186TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88571239
187MYC_18940864_ChIP-ChIP_HL60_Human0.87236925
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84788048
189ELK1_19687146_ChIP-ChIP_HELA_Human0.84169818
190TET1_21451524_ChIP-Seq_MESCs_Mouse0.83673938
191SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82800773
192BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82792259
193ELF5_23300383_ChIP-Seq_T47D_Human0.82723893
194KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82291890
195PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82142206
196DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82017086
197SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80952790
198SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80952790
199HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80737208
200NANOG_21062744_ChIP-ChIP_HESCs_Human0.79299471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.41304678
2MP0001188_hyperpigmentation3.92201517
3MP0003111_abnormal_nucleus_morphology3.72232741
4MP0002877_abnormal_melanocyte_morpholog3.66123721
5MP0009697_abnormal_copulation3.54741002
6MP0006292_abnormal_olfactory_placode3.44637556
7MP0005171_absent_coat_pigmentation3.42738886
8MP0000566_synostosis3.20338765
9MP0005645_abnormal_hypothalamus_physiol3.05439646
10MP0003693_abnormal_embryo_hatching3.00407181
11MP0003077_abnormal_cell_cycle2.94026676
12MP0010234_abnormal_vibrissa_follicle2.93152855
13MP0001986_abnormal_taste_sensitivity2.85996824
14MP0005623_abnormal_meninges_morphology2.84462258
15MP0004957_abnormal_blastocyst_morpholog2.82307569
16MP0010307_abnormal_tumor_latency2.80189980
17MP0005377_hearing/vestibular/ear_phenot2.69872887
18MP0003878_abnormal_ear_physiology2.69872887
19MP0008004_abnormal_stomach_pH2.63649171
20MP0003136_yellow_coat_color2.57380487
21MP0003123_paternal_imprinting2.53289326
22MP0004782_abnormal_surfactant_physiolog2.47892929
23MP0008007_abnormal_cellular_replicative2.41107119
24MP0003941_abnormal_skin_development2.39750574
25MP0003705_abnormal_hypodermis_morpholog2.38000433
26MP0003786_premature_aging2.31408572
27MP0005076_abnormal_cell_differentiation2.28433833
28MP0005646_abnormal_pituitary_gland2.27430276
29MP0008932_abnormal_embryonic_tissue2.26547748
30MP0002735_abnormal_chemical_nociception2.16512436
31MP0002638_abnormal_pupillary_reflex2.13903003
32MP0003787_abnormal_imprinting2.10622016
33MP0002132_abnormal_respiratory_system2.08604786
34MP0000015_abnormal_ear_pigmentation2.06295021
35MP0002938_white_spotting2.02923162
36MP0005409_darkened_coat_color1.96207618
37MP0002396_abnormal_hematopoietic_system1.94421786
38MP0002277_abnormal_respiratory_mucosa1.93999397
39MP0004185_abnormal_adipocyte_glucose1.93025379
40MP0004742_abnormal_vestibular_system1.90214864
41MP0000372_irregular_coat_pigmentation1.89788980
42MP0000537_abnormal_urethra_morphology1.87803342
43MP0000350_abnormal_cell_proliferation1.86331595
44MP0004233_abnormal_muscle_weight1.83101346
45MP0002876_abnormal_thyroid_physiology1.83065779
46MP0003806_abnormal_nucleotide_metabolis1.80661849
47MP0008995_early_reproductive_senescence1.78466280
48MP0010386_abnormal_urinary_bladder1.75389860
49MP0002102_abnormal_ear_morphology1.74478193
50MP0006276_abnormal_autonomic_nervous1.70564015
51MP0001730_embryonic_growth_arrest1.67339859
52MP0001486_abnormal_startle_reflex1.65226410
53MP0001485_abnormal_pinna_reflex1.59512107
54MP0005501_abnormal_skin_physiology1.58498671
55MP0000569_abnormal_digit_pigmentation1.56783166
56MP0000427_abnormal_hair_cycle1.55477504
57MP0005670_abnormal_white_adipose1.52124286
58MP0001984_abnormal_olfaction1.50485571
59MP0002796_impaired_skin_barrier1.48667157
60MP0003453_abnormal_keratinocyte_physiol1.46602593
61MP0008057_abnormal_DNA_replication1.46155245
62MP0005174_abnormal_tail_pigmentation1.45209182
63MP0010678_abnormal_skin_adnexa1.44983984
64MP0000026_abnormal_inner_ear1.44674832
65MP0001697_abnormal_embryo_size1.44108464
66MP0003880_abnormal_central_pattern1.44050734
67MP0003315_abnormal_perineum_morphology1.43820473
68MP0008058_abnormal_DNA_repair1.39204391
69MP0005380_embryogenesis_phenotype1.36360753
70MP0001672_abnormal_embryogenesis/_devel1.36360753
71MP0002148_abnormal_hypersensitivity_rea1.34256018
72MP0001502_abnormal_circadian_rhythm1.33682780
73MP0000678_abnormal_parathyroid_gland1.33599600
74MP0002736_abnormal_nociception_after1.31690392
75MP0005451_abnormal_body_composition1.29150268
76MP0001346_abnormal_lacrimal_gland1.25990943
77MP0001963_abnormal_hearing_physiology1.25246228
78MP0002080_prenatal_lethality1.25082087
79MP0009672_abnormal_birth_weight1.24133153
80MP0001348_abnormal_lacrimal_gland1.24012036
81MP0002009_preneoplasia1.23259950
82MP0002557_abnormal_social/conspecific_i1.22546199
83MP0002163_abnormal_gland_morphology1.22543738
84MP0010352_gastrointestinal_tract_polyps1.22399574
85MP0000579_abnormal_nail_morphology1.22083849
86MP0009764_decreased_sensitivity_to1.20363827
87MP0002234_abnormal_pharynx_morphology1.19984697
88MP0008260_abnormal_autophagy1.19898040
89MP0003984_embryonic_growth_retardation1.19859817
90MP0001661_extended_life_span1.17314894
91MP0010030_abnormal_orbit_morphology1.16795651
92MP0004197_abnormal_fetal_growth/weight/1.16497144
93MP0000383_abnormal_hair_follicle1.16218500
94MP0002084_abnormal_developmental_patter1.16189222
95MP0002085_abnormal_embryonic_tissue1.14890023
96MP0000627_abnormal_mammary_gland1.14325180
97MP0001216_abnormal_epidermal_layer1.13905301
98MP0000313_abnormal_cell_death1.13504699
99MP0002088_abnormal_embryonic_growth/wei1.12846593
100MP0009745_abnormal_behavioral_response1.12546532
101MP0000762_abnormal_tongue_morphology1.12462090
102MP0001968_abnormal_touch/_nociception1.09991338
103MP0003943_abnormal_hepatobiliary_system1.09223895
104MP0005248_abnormal_Harderian_gland1.08924966
105MP0005423_abnormal_somatic_nervous1.08239701
106MP0000049_abnormal_middle_ear1.07488576
107MP0000681_abnormal_thyroid_gland1.07434347
108MP0000358_abnormal_cell_content/1.05614173
109MP0004264_abnormal_extraembryonic_tissu1.05041722
110MP0002210_abnormal_sex_determination1.04524384
111MP0004381_abnormal_hair_follicle1.03854133
112MP0009053_abnormal_anal_canal1.03667784
113MP0002249_abnormal_larynx_morphology1.01584911
114MP0003937_abnormal_limbs/digits/tail_de1.01261634
115MP0002697_abnormal_eye_size1.00967844
116MP0004808_abnormal_hematopoietic_stem1.00492653
117MP0002086_abnormal_extraembryonic_tissu0.99418881
118MP0000467_abnormal_esophagus_morphology0.99226963
119MP0001177_atelectasis0.99000278
120MP0000733_abnormal_muscle_development0.98290579
121MP0006035_abnormal_mitochondrial_morpho0.97376876
122MP0009703_decreased_birth_body0.95486221
123MP0003879_abnormal_hair_cell0.94254216
124MP0002572_abnormal_emotion/affect_behav0.94188160
125MP0003566_abnormal_cell_adhesion0.93733225
126MP0001501_abnormal_sleep_pattern0.93501225
127MP0002060_abnormal_skin_morphology0.92226080
128MP0002111_abnormal_tail_morphology0.90981607
129MP0009785_altered_susceptibility_to0.89592383
130MP0003950_abnormal_plasma_membrane0.89033343
131MP0003724_increased_susceptibility_to0.88555035
132MP0002092_abnormal_eye_morphology0.88111242
133MP0000490_abnormal_crypts_of0.87973561
134MP0002734_abnormal_mechanical_nocicepti0.87474398
135MP0008877_abnormal_DNA_methylation0.86137868
136MP0000778_abnormal_nervous_system0.85714627
137MP0001529_abnormal_vocalization0.84808804
138MP0005083_abnormal_biliary_tract0.83322097
139MP0000516_abnormal_urinary_system0.82449776
140MP0005367_renal/urinary_system_phenotyp0.82449776
141MP0001145_abnormal_male_reproductive0.82362124
142MP0001873_stomach_inflammation0.81273297
143MP0000613_abnormal_salivary_gland0.81255904
144MP0002272_abnormal_nervous_system0.80756276
145MP0001929_abnormal_gametogenesis0.80497558
146MP0002970_abnormal_white_adipose0.80496986
147MP0004147_increased_porphyrin_level0.79860026
148MP0005379_endocrine/exocrine_gland_phen0.79400500
149MP0003942_abnormal_urinary_system0.79259098
150MP0005408_hypopigmentation0.78978397
151MP0001919_abnormal_reproductive_system0.77800254
152MP0002160_abnormal_reproductive_system0.77696171
153MP0005389_reproductive_system_phenotype0.77621552
154MP0003718_maternal_effect0.76647796
155MP0010771_integument_phenotype0.76553144
156MP0005384_cellular_phenotype0.75657618
157MP0001881_abnormal_mammary_gland0.75625733
158MP0000003_abnormal_adipose_tissue0.75595235
159MP0002067_abnormal_sensory_capabilities0.75072342
160MP0002098_abnormal_vibrissa_morphology0.74625232
161MP0001286_abnormal_eye_development0.74195589
162MP0005621_abnormal_cell_physiology0.74048326
163MP0002184_abnormal_innervation0.73769782
164MP0001440_abnormal_grooming_behavior0.73642988
165MP0003699_abnormal_female_reproductive0.72275531
166MP0009046_muscle_twitch0.71501971
167MP0003935_abnormal_craniofacial_develop0.71102573
168MP0005503_abnormal_tendon_morphology0.70983710
169MP0002751_abnormal_autonomic_nervous0.70920780
170MP0005647_abnormal_sex_gland0.70160405
171MP0005253_abnormal_eye_physiology0.70016291
172MP0005551_abnormal_eye_electrophysiolog0.68745331
173MP0002095_abnormal_skin_pigmentation0.68563511
174MP0002064_seizures0.68033000
175MP0003938_abnormal_ear_development0.68018276
176MP0009379_abnormal_foot_pigmentation0.67049802
177MP0001186_pigmentation_phenotype0.66992405
178MP0005386_behavior/neurological_phenoty0.66274998
179MP0004924_abnormal_behavior0.66274998
180MP0000631_abnormal_neuroendocrine_gland0.65376309
181MP0005671_abnormal_response_to0.64125327
182MP0002177_abnormal_outer_ear0.61749994
183MP0002998_abnormal_bone_remodeling0.61541092
184MP0004134_abnormal_chest_morphology0.60994648

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.13464450
2Absent/shortened dynein arms (HP:0200106)5.13464450
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.72969196
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.60105650
5Abnormal ciliary motility (HP:0012262)4.55348062
6Abnormal respiratory motile cilium physiology (HP:0012261)4.28774323
7Chromsome breakage (HP:0040012)4.15485860
8Abnormal respiratory motile cilium morphology (HP:0005938)3.98786839
9Abnormal respiratory epithelium morphology (HP:0012253)3.98786839
10True hermaphroditism (HP:0010459)3.90415761
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87731275
12Abnormality of the distal phalanges of the toes (HP:0010182)3.68873943
13Pancreatic fibrosis (HP:0100732)3.63344711
14Chronic hepatic failure (HP:0100626)3.49989843
15Follicular hyperkeratosis (HP:0007502)3.46142807
16Parakeratosis (HP:0001036)3.40954584
17Abnormality of chromosome stability (HP:0003220)3.37521098
18Rhinitis (HP:0012384)3.36032189
19Flat cornea (HP:0007720)3.34288710
20Septate vagina (HP:0001153)3.30560979
21Chronic bronchitis (HP:0004469)3.28728211
22Febrile seizures (HP:0002373)3.28394460
23Absent eyebrow (HP:0002223)3.26508289
24Duplicated collecting system (HP:0000081)3.16154525
25Abnormality of the fetal cardiovascular system (HP:0010948)3.13306361
26Abnormal umbilical cord blood vessels (HP:0011403)3.13306361
27Single umbilical artery (HP:0001195)3.13306361
28Alopecia of scalp (HP:0002293)3.07129617
29Meckel diverticulum (HP:0002245)3.05776568
30Abnormality of the umbilical cord (HP:0010881)2.92356161
31Abnormality of the renal collecting system (HP:0004742)2.90547629
32Abnormality of the ileum (HP:0001549)2.88637989
33Median cleft lip (HP:0000161)2.86318910
34Pancreatic cysts (HP:0001737)2.85352296
35Tubulointerstitial nephritis (HP:0001970)2.80643450
36Proximal placement of thumb (HP:0009623)2.80080172
37Optic neuritis (HP:0100653)2.77668561
38Retrobulbar optic neuritis (HP:0100654)2.77668561
39Occipital encephalocele (HP:0002085)2.75004645
40Nephronophthisis (HP:0000090)2.74612726
41Deviation of the thumb (HP:0009603)2.73498324
42Abnormality of incisor morphology (HP:0011063)2.71882641
43Nasal polyposis (HP:0100582)2.68898333
44Absent eyelashes (HP:0000561)2.67797150
45Congenital sensorineural hearing impairment (HP:0008527)2.67684182
46Duodenal stenosis (HP:0100867)2.64380841
47Small intestinal stenosis (HP:0012848)2.64380841
48Chronic sinusitis (HP:0011109)2.63492119
49Progressive external ophthalmoplegia (HP:0000590)2.62553887
50White forelock (HP:0002211)2.62458590
51Abnormality of the carotid arteries (HP:0005344)2.60440121
52Abnormality of the renal medulla (HP:0100957)2.58412087
53Alveolar cell carcinoma (HP:0006519)2.54596806
54Birth length less than 3rd percentile (HP:0003561)2.53615958
55Osteomalacia (HP:0002749)2.46931618
56Prostate neoplasm (HP:0100787)2.46680796
57Unilateral renal agenesis (HP:0000122)2.46025984
58Short thumb (HP:0009778)2.40368950
59Preaxial hand polydactyly (HP:0001177)2.38506827
60Increased nuchal translucency (HP:0010880)2.37641921
61Progressive muscle weakness (HP:0003323)2.36436418
62Sclerocornea (HP:0000647)2.33530103
63Patchy hypopigmentation of hair (HP:0011365)2.31788925
64Poikiloderma (HP:0001029)2.31508689
65Decreased central vision (HP:0007663)2.30972612
66Postaxial foot polydactyly (HP:0001830)2.30872393
67Cutaneous melanoma (HP:0012056)2.30652267
68Ulnar bowing (HP:0003031)2.30274348
69Hyperphosphatemia (HP:0002905)2.29724544
70Nephrogenic diabetes insipidus (HP:0009806)2.26997056
71Congenital hepatic fibrosis (HP:0002612)2.26408907
72Hypoplasia of the fovea (HP:0007750)2.26251947
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.26251947
74Cheilitis (HP:0100825)2.26128340
75Abnormal hair whorl (HP:0010721)2.25313515
76Absent radius (HP:0003974)2.25037039
77Aplasia cutis congenita (HP:0001057)2.24516106
78Male infertility (HP:0003251)2.23527354
79Medial flaring of the eyebrow (HP:0010747)2.22997553
80Squamous cell carcinoma (HP:0002860)2.21682705
81Trismus (HP:0000211)2.21169871
82Neoplasm of the tracheobronchial system (HP:0100552)2.20166617
83Abnormality of dental color (HP:0011073)2.18210492
84Abnormality of the phalanges of the hallux (HP:0010057)2.18018246
85Choanal atresia (HP:0000453)2.17191451
86Broad distal phalanx of finger (HP:0009836)2.16207389
87Stomach cancer (HP:0012126)2.15558162
88Hypergonadotropic hypogonadism (HP:0000815)2.15127573
89Submucous cleft hard palate (HP:0000176)2.15101433
90Short nail (HP:0001799)2.14655566
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.14471893
92Bronchiectasis (HP:0002110)2.14425837
93Aplasia involving forearm bones (HP:0009822)2.08071024
94Absent forearm bone (HP:0003953)2.08071024
95Abnormalities of placenta or umbilical cord (HP:0001194)2.07868217
96Molar tooth sign on MRI (HP:0002419)2.07665252
97Abnormality of midbrain morphology (HP:0002418)2.07665252
98Bilateral sensorineural hearing impairment (HP:0008619)2.04034454
99Cystic liver disease (HP:0006706)2.02975196
100Male pseudohermaphroditism (HP:0000037)2.01693960
101Nephroblastoma (Wilms tumor) (HP:0002667)2.00729865
102Septo-optic dysplasia (HP:0100842)1.99322760
103Ectopic kidney (HP:0000086)1.99245931
104Oligohydramnios (HP:0001562)1.98762311
105Fair hair (HP:0002286)1.98547920
106Hand muscle atrophy (HP:0009130)1.96386415
107Supernumerary spleens (HP:0009799)1.95453690
108Abnormality of the renal cortex (HP:0011035)1.94905797
109Atelectasis (HP:0100750)1.94865038
110Abnormality of chromosome segregation (HP:0002916)1.94170888
111Orchitis (HP:0100796)1.93784676
112Sloping forehead (HP:0000340)1.92766572
113Renal cortical cysts (HP:0000803)1.92142486
114Congenital primary aphakia (HP:0007707)1.91490163
115Gait imbalance (HP:0002141)1.91234298
116Abnormality of the duodenum (HP:0002246)1.90916285
117Xerostomia (HP:0000217)1.88880846
118Acute lymphatic leukemia (HP:0006721)1.87729221
119Cafe-au-lait spot (HP:0000957)1.87298504
120Clubbing of toes (HP:0100760)1.86652002
121Anencephaly (HP:0002323)1.86494777
122Hyperacusis (HP:0010780)1.86253216
123Atresia of the external auditory canal (HP:0000413)1.85799065
124Distal upper limb amyotrophy (HP:0007149)1.83955197
125Upper limb amyotrophy (HP:0009129)1.83955197
126Microvesicular hepatic steatosis (HP:0001414)1.83771661
127Keratitis (HP:0000491)1.83303325
128Recurrent corneal erosions (HP:0000495)1.83047655
129Myelodysplasia (HP:0002863)1.82955221
130Dyschromatopsia (HP:0007641)1.81322640
131Facial cleft (HP:0002006)1.80840232
132Abnormality of the nasal mucosa (HP:0000433)1.79964729
133Arteriovenous malformation (HP:0100026)1.78797086
134Epileptic encephalopathy (HP:0200134)1.78634835
135Embryonal renal neoplasm (HP:0011794)1.78419908
136Infertility (HP:0000789)1.78360707
137Hypothermia (HP:0002045)1.77556860
138Reduced antithrombin III activity (HP:0001976)1.77298668
139Abnormality of the fovea (HP:0000493)1.76977616
140Type 2 muscle fiber atrophy (HP:0003554)1.76799277
141Pulmonary artery stenosis (HP:0004415)1.76506254
142Absent hair (HP:0002298)1.76301159
143Pili torti (HP:0003777)1.75809678
144Abnormal biliary tract physiology (HP:0012439)1.75772665
145Bile duct proliferation (HP:0001408)1.75772665
146Hypoplasia of the pons (HP:0012110)1.74755198
147Cerebellar dysplasia (HP:0007033)1.74449241
148Midline defect of the nose (HP:0004122)1.74279697
149Ankyloglossia (HP:0010296)1.73717700
150Conjugated hyperbilirubinemia (HP:0002908)1.73580468
151Testicular atrophy (HP:0000029)1.73209755
152Embryonal neoplasm (HP:0002898)1.73014159
153Triphalangeal thumb (HP:0001199)1.72988912
154Tetany (HP:0001281)1.72838317
155Abnormality of the astrocytes (HP:0100707)1.72753360
156Astrocytoma (HP:0009592)1.72753360
157Abnormality of molar morphology (HP:0011070)1.72089082
158Abnormality of molar (HP:0011077)1.72089082
159Ureteral duplication (HP:0000073)1.71858007
160Absent thumb (HP:0009777)1.71402072
161Abnormality of the preputium (HP:0100587)1.71350044
162Aplasia of the musculature (HP:0100854)1.70520524
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.69786427
164Increased IgM level (HP:0003496)1.69032951
165Abnormality of renal resorption (HP:0011038)1.68428389
166Horseshoe kidney (HP:0000085)1.68360647
1673-Methylglutaconic aciduria (HP:0003535)1.67710091
168Volvulus (HP:0002580)1.67628144
169Duplication of thumb phalanx (HP:0009942)1.67276876
170Breast hypoplasia (HP:0003187)1.66703315
171Selective tooth agenesis (HP:0001592)1.66626482
172Microglossia (HP:0000171)1.66049788
173Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65968003
174Bifid scrotum (HP:0000048)1.64043777
175Microretrognathia (HP:0000308)1.62526038
176Megalocornea (HP:0000485)1.61949393
177Hyperparathyroidism (HP:0000843)1.59460148
178Dysmetric saccades (HP:0000641)1.58490864
179Reduced subcutaneous adipose tissue (HP:0003758)1.57522145
180Ragged-red muscle fibers (HP:0003200)1.55932270
181Self-mutilation (HP:0000742)1.54642540
182Elbow flexion contracture (HP:0002987)1.54589990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.84038603
2MST1R4.32096228
3TNIK4.16808387
4MKNK23.67522397
5BUB13.44370713
6ZAK3.22120913
7STK163.21086718
8TTK2.98409124
9CASK2.93975511
10IRAK32.76976377
11WEE12.66057881
12MAP3K142.62403989
13NME22.59166616
14AKT32.57350106
15TRIB32.45071832
16CDK72.42885505
17IRAK42.41694539
18CDK122.38566837
19MKNK12.24489210
20SMG12.21274241
21CHEK22.20266177
22CDC72.14557409
23TXK2.13082978
24PLK42.12828590
25ICK2.10952474
26MET1.99324957
27EEF2K1.94778606
28INSRR1.92950001
29TSSK61.91270298
30MAP2K71.91045629
31EIF2AK11.82886883
32EIF2AK21.65295578
33YES11.64942643
34MAP3K121.64599339
35STK38L1.57046263
36BRSK11.56984115
37BMPR21.56974673
38CDK41.55245711
39SRPK11.50490724
40PLK11.48309883
41ERBB31.45300830
42NEK11.44415733
43NEK61.38246548
44PLK21.36547896
45TRPM71.36119297
46BRSK21.33209075
47GRK71.31516899
48BMPR1B1.30702244
49AURKA1.29682839
50RPS6KB21.26113876
51MAPK131.26109642
52IRAK21.24920470
53GRK11.21560616
54ADRBK21.20699361
55BCR1.20487134
56SCYL21.20251647
57NLK1.18067284
58MELK1.17406797
59SIK21.16197546
60CCNB11.15452512
61SGK21.13882415
62STK101.12216218
63AURKB1.10428187
64PAK41.07008348
65MAP3K81.05762859
66PRPF4B1.05037243
67NME11.04959732
68MAPK151.04067964
69DAPK21.04022390
70PDK21.03594510
71NUAK11.02926445
72EPHA21.01972840
73IRAK10.96787243
74PNCK0.96158447
75ACVR1B0.94367790
76CHEK10.93022528
77VRK10.92447516
78EPHA40.91639720
79MARK30.91420581
80NEK20.88859306
81LMTK20.88305785
82MAP3K100.87516472
83CDK90.85555401
84CDK30.84989773
85PINK10.84913924
86PKN20.84100313
87IKBKE0.82288642
88PRKCE0.80963773
89PIK3CG0.80164861
90MTOR0.77650584
91LATS20.76860034
92TIE10.76542717
93PIM20.75838820
94PRKCI0.75091386
95SGK2230.74839593
96SGK4940.74839593
97ALK0.74182015
98MUSK0.72566573
99BRD40.71908128
100TEC0.70822567
101AKT20.70082576
102TRIM280.69556403
103PTK20.68706393
104IKBKB0.66153192
105TNK20.65969271
106ERBB40.65662140
107RIPK40.64992345
108CDK60.64383264
109STK40.63241724
110NTRK30.62340632
111CSNK1A1L0.61656894
112ATM0.58937280
113VRK20.56821377
114CHUK0.56228960
115PBK0.55974602
116CDK20.55962047
117SIK10.55511456
118LATS10.54825299
119ARAF0.54189994
120CDK10.53663376
121EPHA30.52951467
122MARK10.52430319
123PKN10.50329874
124BRAF0.50203708
125MAPK70.49282905
126SGK10.43587880
127PRKCG0.43362809
128SGK30.42794125
129MAP3K20.42712920
130TLK10.42560962
131LRRK20.40247350
132DYRK20.39589567
133RAF10.39448245
134MST40.39120795
135TAF10.38813455
136RPS6KA40.38804271
137MAPK110.38692053
138STK240.36569169
139RPS6KB10.36504244
140PRKG10.35772397
141BMX0.35287597
142KIT0.34878446
143CAMK2A0.34809062
144LIMK10.34691970
145TESK10.33640567
146TAOK20.32349362
147CLK10.32346360
148CAMK1D0.32336569
149ILK0.32166553
150LYN0.32136287
151PRKCH0.31807402
152DAPK10.31471354
153MAPK140.31296437
154STK390.31104323
155CAMK2B0.31037520
156DYRK1A0.30898262
157PLK30.30194268
158OXSR10.30093703
159CSNK1E0.30037998
160MAPKAPK30.29605711
161MAP3K90.29307287
162KSR20.28825125
163TGFBR20.28564018
164PRKD30.27733181
165OBSCN0.26553787
166JAK10.26084201
167EPHB20.25692933
168CDK80.25647966
169CAMK2D0.25474234
170CAMKK20.25269952
171ATR0.25185311
172PRKACA0.25136836
173TBK10.24881248
174MATK0.24581034
175PIK3CA0.24368807
176PRKCD0.23994767
177CSNK2A10.23324474
178PRKCQ0.22055646
179ABL10.19407665

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06602226
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.70599646
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19968268
4Cell cycle_Homo sapiens_hsa041102.93932686
5Mismatch repair_Homo sapiens_hsa034302.83127231
6Nicotine addiction_Homo sapiens_hsa050332.80048979
7Fatty acid biosynthesis_Homo sapiens_hsa000612.76254233
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.46969430
9Autoimmune thyroid disease_Homo sapiens_hsa053202.45224059
10Base excision repair_Homo sapiens_hsa034102.42617325
11RNA transport_Homo sapiens_hsa030132.31684403
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24767290
13Spliceosome_Homo sapiens_hsa030402.21795884
14Nucleotide excision repair_Homo sapiens_hsa034202.15634976
15SNARE interactions in vesicular transport_Homo sapiens_hsa041302.08605364
16Fanconi anemia pathway_Homo sapiens_hsa034602.05651485
17Arachidonic acid metabolism_Homo sapiens_hsa005902.05075151
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85355307
19One carbon pool by folate_Homo sapiens_hsa006701.84882052
20Taste transduction_Homo sapiens_hsa047421.82045872
21Pentose phosphate pathway_Homo sapiens_hsa000301.79214565
22Allograft rejection_Homo sapiens_hsa053301.75758291
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74830428
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.73317617
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70626626
26Biosynthesis of amino acids_Homo sapiens_hsa012301.68252671
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68005062
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64958399
29Homologous recombination_Homo sapiens_hsa034401.63954513
30Sulfur relay system_Homo sapiens_hsa041221.62943115
31Graft-versus-host disease_Homo sapiens_hsa053321.54497285
32Rheumatoid arthritis_Homo sapiens_hsa053231.49494637
33Serotonergic synapse_Homo sapiens_hsa047261.47826839
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46858630
35mRNA surveillance pathway_Homo sapiens_hsa030151.46717233
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46284160
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44381454
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44245604
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42956640
40Morphine addiction_Homo sapiens_hsa050321.42919784
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.41797984
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40335299
43Primary immunodeficiency_Homo sapiens_hsa053401.37557713
44Basal transcription factors_Homo sapiens_hsa030221.33282957
45Phototransduction_Homo sapiens_hsa047441.32987956
46Thyroid cancer_Homo sapiens_hsa052161.32925550
47Folate biosynthesis_Homo sapiens_hsa007901.32843155
48Vitamin B6 metabolism_Homo sapiens_hsa007501.31284442
49Proteasome_Homo sapiens_hsa030501.29031545
50Sphingolipid metabolism_Homo sapiens_hsa006001.27756124
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26844797
52Circadian rhythm_Homo sapiens_hsa047101.25703297
53p53 signaling pathway_Homo sapiens_hsa041151.25243775
54N-Glycan biosynthesis_Homo sapiens_hsa005101.24170529
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24038736
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22884791
57Measles_Homo sapiens_hsa051621.22203383
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.21698783
59Hematopoietic cell lineage_Homo sapiens_hsa046401.21142431
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17012327
61Type I diabetes mellitus_Homo sapiens_hsa049401.16432164
62Hedgehog signaling pathway_Homo sapiens_hsa043401.15439002
63Pancreatic cancer_Homo sapiens_hsa052121.13209594
64Olfactory transduction_Homo sapiens_hsa047401.13206551
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12122699
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10470259
67Bladder cancer_Homo sapiens_hsa052191.08592527
68Hippo signaling pathway_Homo sapiens_hsa043901.07645137
69Ether lipid metabolism_Homo sapiens_hsa005651.06351485
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05691407
71TNF signaling pathway_Homo sapiens_hsa046681.05148959
72Small cell lung cancer_Homo sapiens_hsa052221.04488302
73Mineral absorption_Homo sapiens_hsa049781.03707927
74Chronic myeloid leukemia_Homo sapiens_hsa052201.03451971
75Glutamatergic synapse_Homo sapiens_hsa047241.03203720
76Histidine metabolism_Homo sapiens_hsa003401.02178412
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99550285
78Pyruvate metabolism_Homo sapiens_hsa006200.98295551
79Calcium signaling pathway_Homo sapiens_hsa040200.98094196
80Carbon metabolism_Homo sapiens_hsa012000.97204921
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.96750271
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.96577286
83RNA degradation_Homo sapiens_hsa030180.96577028
84Collecting duct acid secretion_Homo sapiens_hsa049660.96404522
85Asthma_Homo sapiens_hsa053100.92942856
86Protein export_Homo sapiens_hsa030600.92373784
87Oocyte meiosis_Homo sapiens_hsa041140.91821611
88Non-homologous end-joining_Homo sapiens_hsa034500.89279243
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88827812
90Ribosome_Homo sapiens_hsa030100.88417364
91Circadian entrainment_Homo sapiens_hsa047130.85463504
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84448149
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83447434
94Phagosome_Homo sapiens_hsa041450.82969339
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82763038
96African trypanosomiasis_Homo sapiens_hsa051430.81066799
97Linoleic acid metabolism_Homo sapiens_hsa005910.80794015
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79508246
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79479161
100GABAergic synapse_Homo sapiens_hsa047270.79371763
101Melanoma_Homo sapiens_hsa052180.79250024
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78359461
103Viral carcinogenesis_Homo sapiens_hsa052030.74887730
104Vitamin digestion and absorption_Homo sapiens_hsa049770.74328910
105Synaptic vesicle cycle_Homo sapiens_hsa047210.73867049
106Basal cell carcinoma_Homo sapiens_hsa052170.71886239
107Axon guidance_Homo sapiens_hsa043600.69350852
108Adherens junction_Homo sapiens_hsa045200.68315180
109Ovarian steroidogenesis_Homo sapiens_hsa049130.68113027
110Fructose and mannose metabolism_Homo sapiens_hsa000510.67393688
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.66607500
112Purine metabolism_Homo sapiens_hsa002300.64909290
113MicroRNAs in cancer_Homo sapiens_hsa052060.64878456
114Insulin secretion_Homo sapiens_hsa049110.64781276
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64674311
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63578349
117Wnt signaling pathway_Homo sapiens_hsa043100.62283009
118Inositol phosphate metabolism_Homo sapiens_hsa005620.59900160
119Fatty acid metabolism_Homo sapiens_hsa012120.59794593
120Fatty acid elongation_Homo sapiens_hsa000620.59639721
121Non-small cell lung cancer_Homo sapiens_hsa052230.58964437
122Influenza A_Homo sapiens_hsa051640.58377526
123TGF-beta signaling pathway_Homo sapiens_hsa043500.58036466
124Regulation of autophagy_Homo sapiens_hsa041400.57659616
125HTLV-I infection_Homo sapiens_hsa051660.56915735
126Arginine and proline metabolism_Homo sapiens_hsa003300.55737478
127Tuberculosis_Homo sapiens_hsa051520.55694181
128Oxidative phosphorylation_Homo sapiens_hsa001900.55333190
129Prostate cancer_Homo sapiens_hsa052150.54991986
130Glutathione metabolism_Homo sapiens_hsa004800.54732689
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.54490954
132Other glycan degradation_Homo sapiens_hsa005110.53271021
133Legionellosis_Homo sapiens_hsa051340.52879666
134Herpes simplex infection_Homo sapiens_hsa051680.51945566
135Huntingtons disease_Homo sapiens_hsa050160.51725909
136ErbB signaling pathway_Homo sapiens_hsa040120.51578742
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51141198
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50607235
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48532045
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48327118
141Lysine degradation_Homo sapiens_hsa003100.48278239
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46922256
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46150017
144Pyrimidine metabolism_Homo sapiens_hsa002400.45616005
145Malaria_Homo sapiens_hsa051440.45194837
146Proteoglycans in cancer_Homo sapiens_hsa052050.45159014
147Cholinergic synapse_Homo sapiens_hsa047250.44388555
148Notch signaling pathway_Homo sapiens_hsa043300.44214357
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.44183294
150Leishmaniasis_Homo sapiens_hsa051400.44110926
151Amphetamine addiction_Homo sapiens_hsa050310.42430811
152AMPK signaling pathway_Homo sapiens_hsa041520.42289454
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41551968
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40316507
155beta-Alanine metabolism_Homo sapiens_hsa004100.39947956
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39649181
157RNA polymerase_Homo sapiens_hsa030200.39125121
158cAMP signaling pathway_Homo sapiens_hsa040240.38613765
159mTOR signaling pathway_Homo sapiens_hsa041500.38477542
160Salivary secretion_Homo sapiens_hsa049700.38348496
161Selenocompound metabolism_Homo sapiens_hsa004500.38141712
162Hepatitis C_Homo sapiens_hsa051600.37583347
163Chemokine signaling pathway_Homo sapiens_hsa040620.37549901
164Melanogenesis_Homo sapiens_hsa049160.36871238
165Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35984455
166Cocaine addiction_Homo sapiens_hsa050300.35963357
167Endometrial cancer_Homo sapiens_hsa052130.35757232
168Epstein-Barr virus infection_Homo sapiens_hsa051690.34593293
169Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34425001
170Phenylalanine metabolism_Homo sapiens_hsa003600.34264374
171Colorectal cancer_Homo sapiens_hsa052100.34044072
172Galactose metabolism_Homo sapiens_hsa000520.33921863
173Metabolic pathways_Homo sapiens_hsa011000.33287429
174Pathways in cancer_Homo sapiens_hsa052000.32378865
175Glioma_Homo sapiens_hsa052140.32293489
176Vibrio cholerae infection_Homo sapiens_hsa051100.31648014
177Apoptosis_Homo sapiens_hsa042100.31206507
178Alcoholism_Homo sapiens_hsa050340.29602502
179Insulin signaling pathway_Homo sapiens_hsa049100.27624948
180Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25953574

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