MCHR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.85425751
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55979610
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55218408
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47943377
5neuron cell-cell adhesion (GO:0007158)5.36799467
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.03985479
7regulation of glutamate receptor signaling pathway (GO:1900449)4.96724098
8locomotory exploration behavior (GO:0035641)4.90747747
9synaptic vesicle exocytosis (GO:0016079)4.85627199
10protein localization to synapse (GO:0035418)4.83140967
11neurotransmitter-gated ion channel clustering (GO:0072578)4.67582390
12glutamate receptor signaling pathway (GO:0007215)4.55808121
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.54866481
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45244395
15peripheral nervous system axon ensheathment (GO:0032292)4.41509544
16myelination in peripheral nervous system (GO:0022011)4.41509544
17neuronal action potential propagation (GO:0019227)4.41351208
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38034547
19cell migration in hindbrain (GO:0021535)4.35583474
20sodium ion export (GO:0071436)4.34113325
21neuron-neuron synaptic transmission (GO:0007270)4.27854067
22synaptic vesicle maturation (GO:0016188)4.27711776
23synaptic transmission, glutamatergic (GO:0035249)4.26121522
24cellular potassium ion homeostasis (GO:0030007)4.24805050
25glutamate secretion (GO:0014047)4.23823428
26regulation of synaptic vesicle exocytosis (GO:2000300)4.22924307
27regulation of neuronal synaptic plasticity (GO:0048168)4.19021857
28presynaptic membrane assembly (GO:0097105)4.16853108
29behavioral fear response (GO:0001662)4.14365821
30behavioral defense response (GO:0002209)4.14365821
31exploration behavior (GO:0035640)4.13923706
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12836293
33synaptic vesicle docking involved in exocytosis (GO:0016081)4.10131618
34regulation of dendritic spine morphogenesis (GO:0061001)4.04275701
35long-term synaptic potentiation (GO:0060291)4.02220801
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.99344445
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98811342
38postsynaptic membrane organization (GO:0001941)3.95264794
39long-term memory (GO:0007616)3.93854563
40neurotransmitter secretion (GO:0007269)3.93281791
41regulation of postsynaptic membrane potential (GO:0060078)3.91774867
42mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.89087994
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87781923
44fear response (GO:0042596)3.85822538
45neuron recognition (GO:0008038)3.83827759
46presynaptic membrane organization (GO:0097090)3.81889048
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.80575556
48transmission of nerve impulse (GO:0019226)3.78471726
49regulation of synaptic vesicle transport (GO:1902803)3.78433343
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.78275642
51glial cell proliferation (GO:0014009)3.77842080
52regulation of synapse structural plasticity (GO:0051823)3.76466426
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.75732367
54response to histamine (GO:0034776)3.74448192
55regulation of glutamate secretion (GO:0014048)3.73024017
56regulation of synaptic plasticity (GO:0048167)3.69904859
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67522053
58synaptic transmission, dopaminergic (GO:0001963)3.67396567
59dendritic spine morphogenesis (GO:0060997)3.67310723
60positive regulation of membrane potential (GO:0045838)3.65620758
61behavioral response to cocaine (GO:0048148)3.63392652
62positive regulation of neurotransmitter secretion (GO:0001956)3.60440680
63striatum development (GO:0021756)3.49696962
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47355993
65establishment of mitochondrion localization (GO:0051654)3.46805981
66positive regulation of neurotransmitter transport (GO:0051590)3.45189085
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44640179
68regulation of dendritic spine development (GO:0060998)3.44301059
69regulation of female receptivity (GO:0045924)3.40879430
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40701645
71layer formation in cerebral cortex (GO:0021819)3.40386175
72auditory behavior (GO:0031223)3.40174901
73activation of protein kinase A activity (GO:0034199)3.36208680
74response to amphetamine (GO:0001975)3.35038235
75membrane hyperpolarization (GO:0060081)3.31025113
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29724916
77female mating behavior (GO:0060180)3.28558139
78axonal fasciculation (GO:0007413)3.27782526
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27465142
80prepulse inhibition (GO:0060134)3.27170226
81learning (GO:0007612)3.25886202
82synaptic vesicle endocytosis (GO:0048488)3.25499720
83membrane depolarization (GO:0051899)3.24990982
84neurotransmitter transport (GO:0006836)3.24751022
85startle response (GO:0001964)3.24513870
86positive regulation of synapse maturation (GO:0090129)3.24475647
87negative regulation of dendrite development (GO:2000171)3.24467238
88potassium ion homeostasis (GO:0055075)3.20866704
89innervation (GO:0060384)3.17472259
90cerebellar granule cell differentiation (GO:0021707)3.16920283
91proline transport (GO:0015824)3.12608281
92regulation of protein kinase A signaling (GO:0010738)3.12561710
93positive regulation of synaptic transmission (GO:0050806)3.12481120
94gamma-aminobutyric acid transport (GO:0015812)3.10867849
95cranial nerve structural organization (GO:0021604)3.10347790
96response to auditory stimulus (GO:0010996)3.06830542
97neuron projection regeneration (GO:0031102)3.06666567
98regulation of neurotransmitter levels (GO:0001505)3.06551382
99regulation of vesicle fusion (GO:0031338)3.05394744
100neuronal ion channel clustering (GO:0045161)3.05152871
101metanephric mesenchyme development (GO:0072075)3.05132123
102positive regulation of synapse assembly (GO:0051965)3.03525827
103mating behavior (GO:0007617)3.02335672
104neuromuscular process controlling balance (GO:0050885)3.00960596
105positive regulation of dendritic spine development (GO:0060999)3.00246982
106synaptic transmission (GO:0007268)2.98315822
107camera-type eye morphogenesis (GO:0048593)2.97485740
108regulation of voltage-gated calcium channel activity (GO:1901385)2.97235865
109axon regeneration (GO:0031103)2.96482500
110regulation of synaptic transmission, GABAergic (GO:0032228)2.96300792
111regulation of neurotransmitter secretion (GO:0046928)2.96069463
112mechanosensory behavior (GO:0007638)2.95485485
113negative regulation of amino acid transport (GO:0051956)2.95391168
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94630270
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92905540
116regulation of synaptic transmission (GO:0050804)2.92588198
117amino acid import (GO:0043090)2.91556420
118detection of calcium ion (GO:0005513)2.90474593
119cochlea development (GO:0090102)2.89863077
120neuron maturation (GO:0042551)2.88836715
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85904390
122negative regulation of dendrite morphogenesis (GO:0050774)2.84748090
123cell communication by electrical coupling (GO:0010644)2.82089842
124central nervous system myelination (GO:0022010)2.79635575
125axon ensheathment in central nervous system (GO:0032291)2.79635575
126L-amino acid import (GO:0043092)2.73687448
127neuromuscular synaptic transmission (GO:0007274)2.72292014
128collecting duct development (GO:0072044)2.69716950
129metanephric nephron tubule development (GO:0072234)2.69573501
130metanephric tubule development (GO:0072170)2.69573501
131regulation of respiratory gaseous exchange (GO:0043576)2.65726520
132regulation of neurotransmitter transport (GO:0051588)2.65090827
133neuron remodeling (GO:0016322)2.64224125
134establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63405209
135mitochondrion transport along microtubule (GO:0047497)2.63405209
136lateral sprouting from an epithelium (GO:0060601)2.61326256
137cellular sodium ion homeostasis (GO:0006883)2.60287263
138axon cargo transport (GO:0008088)2.59954636
139kidney mesenchyme development (GO:0072074)2.55920947
140cranial nerve morphogenesis (GO:0021602)2.55368879
141neurofilament cytoskeleton organization (GO:0060052)2.55176585
142endothelial cell chemotaxis (GO:0035767)2.53965569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83752922
2GBX2_23144817_ChIP-Seq_PC3_Human4.04482040
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28517535
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25475290
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20597630
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89141725
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.83844881
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79159515
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79159515
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74165936
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.73246090
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.72580286
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.67968814
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55399226
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.55385872
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52342029
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49101271
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.40921680
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35513178
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29839646
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.25546110
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21723339
23TAF15_26573619_Chip-Seq_HEK293_Human2.20673920
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19441616
25DROSHA_22980978_ChIP-Seq_HELA_Human2.10443845
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.09769506
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06574796
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01798247
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00114816
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98700119
31AR_21572438_ChIP-Seq_LNCaP_Human1.97905732
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86166847
33KDM2B_26808549_Chip-Seq_K562_Human1.83826190
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80488947
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79881640
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75743584
37SMAD4_21799915_ChIP-Seq_A2780_Human1.69793248
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.68069953
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67893326
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67533210
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67480680
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.64408527
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62687069
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61621345
45P300_19829295_ChIP-Seq_ESCs_Human1.58928456
46CTCF_27219007_Chip-Seq_Bcells_Human1.57869383
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56062412
48VDR_22108803_ChIP-Seq_LS180_Human1.55608183
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54192198
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.54181619
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.51623419
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.50346332
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49699118
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46520920
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44999235
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44474044
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44455332
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43607045
59LXR_22292898_ChIP-Seq_THP-1_Human1.39281163
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38466292
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37880169
62ZNF274_21170338_ChIP-Seq_K562_Hela1.37853126
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37721531
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31593974
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31498093
66FUS_26573619_Chip-Seq_HEK293_Human1.30546750
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.29973297
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28077181
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27830798
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.27212746
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.26020044
72AR_25329375_ChIP-Seq_VCAP_Human1.25332504
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24841153
74RNF2_27304074_Chip-Seq_NSC_Mouse1.24690358
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24054351
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20675367
77IGF1R_20145208_ChIP-Seq_DFB_Human1.20328818
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.19592899
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18314974
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.18299512
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17825054
82STAT3_23295773_ChIP-Seq_U87_Human1.16957857
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15639955
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14687629
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10531340
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.09859360
87AR_19668381_ChIP-Seq_PC3_Human1.09512669
88ER_23166858_ChIP-Seq_MCF-7_Human1.08415625
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08261044
90TCF4_23295773_ChIP-Seq_U87_Human1.07830029
91* EGR1_19032775_ChIP-ChIP_M12_Human1.06986049
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06946336
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.06936274
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06483492
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05654450
96TP53_16413492_ChIP-PET_HCT116_Human1.05452557
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04647991
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02742563
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01590437
100RUNX2_22187159_ChIP-Seq_PCA_Human1.01162014
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00871554
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00788159
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00446803
104JUN_21703547_ChIP-Seq_K562_Human0.99368725
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99354344
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98773008
107* ARNT_22903824_ChIP-Seq_MCF-7_Human0.98026712
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96454039
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.96347500
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96154504
111BCAT_22108803_ChIP-Seq_LS180_Human0.96129633
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95467093
113TP53_18474530_ChIP-ChIP_U2OS_Human0.95466665
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95393305
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.95203192
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95044009
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94401363
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94396539
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94396539
120* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94358632
121* AHR_22903824_ChIP-Seq_MCF-7_Human0.92727826
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92118335
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91748720
124* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89724080
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89583039
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88999690
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87549922
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.87397299
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87295869
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87077094
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.86719792
132SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85821890
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85794874
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.85360474
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.85296660
136RXR_22108803_ChIP-Seq_LS180_Human0.85251433
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85200417
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84947330
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84926015
140CLOCK_20551151_ChIP-Seq_293T_Human0.84290170
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82013446
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81585743
143* SMC4_20622854_ChIP-Seq_HELA_Human0.81555506
144* SA1_27219007_Chip-Seq_ERYTHROID_Human0.79938753
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79316708
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77391639
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77085632
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.75954478
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.75944345
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75412602
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74799689
152KDM2B_26808549_Chip-Seq_DND41_Human0.74332283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.17795141
2MP0003880_abnormal_central_pattern5.48717090
3MP0003635_abnormal_synaptic_transmissio4.16032993
4MP0002822_catalepsy3.77643858
5* MP0009745_abnormal_behavioral_response3.71093130
6* MP0002063_abnormal_learning/memory/cond3.48118938
7MP0004270_analgesia3.47988775
8MP0003878_abnormal_ear_physiology3.41408498
9MP0005377_hearing/vestibular/ear_phenot3.41408498
10MP0002064_seizures3.21418904
11MP0005257_abnormal_intraocular_pressure3.20888697
12MP0001968_abnormal_touch/_nociception3.13041584
13MP0009046_muscle_twitch3.00086940
14* MP0002572_abnormal_emotion/affect_behav2.90322044
15MP0002736_abnormal_nociception_after2.77926326
16* MP0002272_abnormal_nervous_system2.68106526
17MP0001486_abnormal_startle_reflex2.55385101
18MP0005423_abnormal_somatic_nervous2.52887616
19MP0001529_abnormal_vocalization2.46879034
20MP0001440_abnormal_grooming_behavior2.30699562
21MP0002734_abnormal_mechanical_nocicepti2.27408126
22MP0002735_abnormal_chemical_nociception2.27397964
23* MP0001501_abnormal_sleep_pattern2.24751464
24MP0003123_paternal_imprinting2.03273569
25MP0002067_abnormal_sensory_capabilities1.91894247
26MP0005646_abnormal_pituitary_gland1.88639543
27MP0001970_abnormal_pain_threshold1.87473370
28MP0002733_abnormal_thermal_nociception1.80332848
29MP0002184_abnormal_innervation1.75197638
30MP0005386_behavior/neurological_phenoty1.72734539
31MP0004924_abnormal_behavior1.72734539
32MP0001984_abnormal_olfaction1.71575641
33MP0009780_abnormal_chondrocyte_physiolo1.69991833
34* MP0002557_abnormal_social/conspecific_i1.68882761
35MP0003329_amyloid_beta_deposits1.68724687
36MP0000778_abnormal_nervous_system1.64961655
37MP0006276_abnormal_autonomic_nervous1.62499139
38MP0002837_dystrophic_cardiac_calcinosis1.61518779
39MP0002909_abnormal_adrenal_gland1.57792758
40MP0004811_abnormal_neuron_physiology1.52790813
41MP0002638_abnormal_pupillary_reflex1.49596355
42MP0001905_abnormal_dopamine_level1.49361039
43MP0004858_abnormal_nervous_system1.46256190
44MP0003879_abnormal_hair_cell1.46228858
45MP0008569_lethality_at_weaning1.42515479
46MP0000955_abnormal_spinal_cord1.40027909
47MP0004142_abnormal_muscle_tone1.39630685
48MP0001188_hyperpigmentation1.38958112
49* MP0002066_abnormal_motor_capabilities/c1.37653258
50MP0004145_abnormal_muscle_electrophysio1.31869804
51MP0002882_abnormal_neuron_morphology1.29704264
52MP0000751_myopathy1.28974463
53MP0003787_abnormal_imprinting1.24020946
54MP0001348_abnormal_lacrimal_gland1.20938464
55MP0003633_abnormal_nervous_system1.18320043
56MP0005645_abnormal_hypothalamus_physiol1.15975496
57MP0000579_abnormal_nail_morphology1.15521590
58MP0002751_abnormal_autonomic_nervous1.12535769
59MP0008872_abnormal_physiological_respon1.09190484
60MP0003121_genomic_imprinting1.07811106
61MP0001502_abnormal_circadian_rhythm1.04861959
62MP0004885_abnormal_endolymph1.04752441
63MP0003122_maternal_imprinting1.04372301
64MP0005409_darkened_coat_color1.04187471
65MP0000013_abnormal_adipose_tissue1.02588093
66MP0008874_decreased_physiological_sensi1.01932520
67MP0003631_nervous_system_phenotype1.01188546
68MP0004742_abnormal_vestibular_system1.00620143
69MP0002152_abnormal_brain_morphology0.99164539
70MP0005248_abnormal_Harderian_gland0.97504793
71* MP0002069_abnormal_eating/drinking_beha0.97138195
72MP0000534_abnormal_ureter_morphology0.93646353
73MP0001664_abnormal_digestion0.92636077
74MP0002102_abnormal_ear_morphology0.91350266
75* MP0004085_abnormal_heartbeat0.89571746
76MP0004272_abnormal_basement_membrane0.89524686
77MP0002876_abnormal_thyroid_physiology0.89523029
78MP0001963_abnormal_hearing_physiology0.85666981
79MP0000631_abnormal_neuroendocrine_gland0.85248446
80MP0010386_abnormal_urinary_bladder0.84873174
81MP0005551_abnormal_eye_electrophysiolog0.84351308
82MP0005623_abnormal_meninges_morphology0.83763144
83* MP0005535_abnormal_body_temperature0.83223082
84MP0002229_neurodegeneration0.82533904
85MP0000920_abnormal_myelination0.78233923
86MP0003075_altered_response_to0.77402591
87MP0004215_abnormal_myocardial_fiber0.76604663
88MP0003283_abnormal_digestive_organ0.76214133
89MP0003183_abnormal_peptide_metabolism0.75438909
90MP0003861_abnormal_nervous_system0.75345713
91MP0002653_abnormal_ependyma_morphology0.74384110
92MP0004484_altered_response_of0.74178390
93MP0001177_atelectasis0.72860940
94MP0002752_abnormal_somatic_nervous0.72509462
95MP0000604_amyloidosis0.71974966
96MP0005171_absent_coat_pigmentation0.71773988
97MP0002090_abnormal_vision0.69821393
98MP0003634_abnormal_glial_cell0.68658901
99MP0006292_abnormal_olfactory_placode0.67057376
100MP0003942_abnormal_urinary_system0.65773659
101MP0001299_abnormal_eye_distance/0.65766612
102MP0010030_abnormal_orbit_morphology0.65364293
103MP0008877_abnormal_DNA_methylation0.65132135
104MP0003690_abnormal_glial_cell0.64678641
105MP0003632_abnormal_nervous_system0.62899460
106MP0000026_abnormal_inner_ear0.62700485
107MP0005499_abnormal_olfactory_system0.62290625
108MP0005394_taste/olfaction_phenotype0.62290625
109MP0000639_abnormal_adrenal_gland0.62209437
110MP0003119_abnormal_digestive_system0.61713394
111MP0002089_abnormal_postnatal_growth/wei0.61566830
112MP0001485_abnormal_pinna_reflex0.61560358
113MP0003137_abnormal_impulse_conducting0.60244199
114MP0005187_abnormal_penis_morphology0.60233494
115MP0001943_abnormal_respiration0.58128231
116MP0000747_muscle_weakness0.55790292
117MP0002697_abnormal_eye_size0.55195665
118MP0004510_myositis0.55037935
119MP0003646_muscle_fatigue0.54928761
120MP0001324_abnormal_eye_pigmentation0.54751086
121MP0010769_abnormal_survival0.53991722
122MP0003315_abnormal_perineum_morphology0.53859193
123MP0005197_abnormal_uvea_morphology0.53309533
124MP0003938_abnormal_ear_development0.52561599
125MP0001756_abnormal_urination0.52511758
126MP0005167_abnormal_blood-brain_barrier0.52248367
127MP0008961_abnormal_basal_metabolism0.50605449
128MP0004036_abnormal_muscle_relaxation0.50049761
129MP0005620_abnormal_muscle_contractility0.49840649
130MP0004233_abnormal_muscle_weight0.48341243
131MP0002234_abnormal_pharynx_morphology0.47965698

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.23868146
2Myokymia (HP:0002411)7.32684178
3Focal seizures (HP:0007359)5.86275333
4Atonic seizures (HP:0010819)5.16420145
5Epileptic encephalopathy (HP:0200134)5.13720781
6Visual hallucinations (HP:0002367)4.87864330
7Nuclear cataract (HP:0100018)4.58349120
8Absence seizures (HP:0002121)4.58007985
9Hyperventilation (HP:0002883)4.55438562
10Febrile seizures (HP:0002373)4.27716965
11Dialeptic seizures (HP:0011146)4.17296184
12Generalized tonic-clonic seizures (HP:0002069)3.97899782
13Broad-based gait (HP:0002136)3.97130779
14Peripheral hypomyelination (HP:0007182)3.90428207
15Progressive cerebellar ataxia (HP:0002073)3.64947950
16Aplasia involving bones of the extremities (HP:0009825)3.61389040
17Aplasia involving bones of the upper limbs (HP:0009823)3.61389040
18Aplasia of the phalanges of the hand (HP:0009802)3.61389040
19Amblyopia (HP:0000646)3.45738066
20Poor eye contact (HP:0000817)3.34417216
21Anxiety (HP:0000739)3.28695948
22Impaired vibration sensation in the lower limbs (HP:0002166)3.16638206
23Impaired social interactions (HP:0000735)3.12202992
24Abnormal social behavior (HP:0012433)3.12202992
25Dysdiadochokinesis (HP:0002075)3.05749715
26Progressive inability to walk (HP:0002505)3.03797923
27Cerebral inclusion bodies (HP:0100314)3.02531167
28Gaze-evoked nystagmus (HP:0000640)2.97614090
29Dysmetria (HP:0001310)2.94878735
30Alacrima (HP:0000522)2.93495177
31Drooling (HP:0002307)2.91726442
32Excessive salivation (HP:0003781)2.91726442
33Supranuclear gaze palsy (HP:0000605)2.88205906
34Abnormal eating behavior (HP:0100738)2.84588029
35Partial duplication of thumb phalanx (HP:0009944)2.83284716
36Heterochromia iridis (HP:0001100)2.82438960
37Truncal ataxia (HP:0002078)2.80570989
38Obstructive sleep apnea (HP:0002870)2.78856603
39Depression (HP:0000716)2.77094827
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76013526
41Neurofibrillary tangles (HP:0002185)2.74495668
42Action tremor (HP:0002345)2.71910595
43Inability to walk (HP:0002540)2.70248350
44Turricephaly (HP:0000262)2.65459730
45Hand muscle atrophy (HP:0009130)2.62661515
46Partial duplication of the phalanx of hand (HP:0009999)2.57302210
47Nonprogressive disorder (HP:0003680)2.55096727
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.54865702
49Absent/shortened dynein arms (HP:0200106)2.54865702
50Fetal akinesia sequence (HP:0001989)2.54850488
51Epileptiform EEG discharges (HP:0011182)2.53934600
52Ankle clonus (HP:0011448)2.45837799
53Focal dystonia (HP:0004373)2.43976575
54Torticollis (HP:0000473)2.43278774
55Glomerulonephritis (HP:0000099)2.36507929
56Anosmia (HP:0000458)2.35071700
57Abnormality of the lower motor neuron (HP:0002366)2.34976869
58Absent speech (HP:0001344)2.34095173
59Hemiparesis (HP:0001269)2.33218581
60Urinary bladder sphincter dysfunction (HP:0002839)2.32664870
61Abnormality of the musculature of the hand (HP:0001421)2.32326744
62Abnormality of binocular vision (HP:0011514)2.31628618
63Diplopia (HP:0000651)2.31628618
64Polyphagia (HP:0002591)2.30322182
65EEG with generalized epileptiform discharges (HP:0011198)2.30278854
66Stereotypic behavior (HP:0000733)2.28922799
67Sleep apnea (HP:0010535)2.28624787
68Resting tremor (HP:0002322)2.28295136
69Facial shape deformation (HP:0011334)2.25517584
70Potter facies (HP:0002009)2.25517584
71Status epilepticus (HP:0002133)2.19223379
72Ulnar claw (HP:0001178)2.19035059
73Abnormal ciliary motility (HP:0012262)2.18095525
74Distal upper limb amyotrophy (HP:0007149)2.16708967
75Upper limb amyotrophy (HP:0009129)2.16708967
76Acute necrotizing encephalopathy (HP:0006965)2.16599610
77Mild short stature (HP:0003502)2.14397182
78Delusions (HP:0000746)2.14215505
79Bradykinesia (HP:0002067)2.14065109
80Hypsarrhythmia (HP:0002521)2.13573268
81Craniofacial dystonia (HP:0012179)2.13102261
82Generalized myoclonic seizures (HP:0002123)2.11512094
83Insomnia (HP:0100785)2.10894443
84Cerebral hypomyelination (HP:0006808)2.10669826
85Limb dystonia (HP:0002451)2.09734284
86Mutism (HP:0002300)2.09211261
87Lower limb amyotrophy (HP:0007210)2.08884570
88Impaired vibratory sensation (HP:0002495)2.08264511
89Impaired smooth pursuit (HP:0007772)2.08053729
90Scanning speech (HP:0002168)2.07974666
91Cholecystitis (HP:0001082)2.06965780
92Abnormal gallbladder physiology (HP:0012438)2.06965780
93Postural instability (HP:0002172)2.06755163
94Decreased lacrimation (HP:0000633)2.06573958
95Poor suck (HP:0002033)2.05562772
96Protruding tongue (HP:0010808)2.05136899
97Blue irides (HP:0000635)2.04792857
98Urinary urgency (HP:0000012)2.04465172
99Annular pancreas (HP:0001734)2.04414614
100Psychosis (HP:0000709)2.03614570
101Incomplete penetrance (HP:0003829)2.03100969
102Hammertoe (HP:0001765)2.01256557
103Split foot (HP:0001839)2.00591160
104Abnormality of salivation (HP:0100755)1.99881919
105Abnormal respiratory motile cilium physiology (HP:0012261)1.99851343
106Bicornuate uterus (HP:0000813)1.99818137
107Spastic gait (HP:0002064)1.98748340
108Hyperextensible skin (HP:0000974)1.98659144
109Akinesia (HP:0002304)1.97363957
110Abnormal mitochondria in muscle tissue (HP:0008316)1.96874220
111Pheochromocytoma (HP:0002666)1.96516696
112Intention tremor (HP:0002080)1.95569199
113Neuroendocrine neoplasm (HP:0100634)1.95394520
114Progressive macrocephaly (HP:0004481)1.94687119
115Dysmetric saccades (HP:0000641)1.94341141
116Abnormal respiratory motile cilium morphology (HP:0005938)1.94133904
117Abnormal respiratory epithelium morphology (HP:0012253)1.94133904
118Hydroureter (HP:0000072)1.93767989
119Morphological abnormality of the middle ear (HP:0008609)1.89381398
120Hyperacusis (HP:0010780)1.89322439
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88752405
122Abnormal hair whorl (HP:0010721)1.88298532
123Megalencephaly (HP:0001355)1.88036203
124Segmental peripheral demyelination/remyelination (HP:0003481)1.87954425
125Sensory axonal neuropathy (HP:0003390)1.87037549
126Muscle hypertrophy of the lower extremities (HP:0008968)1.86517993
127Arnold-Chiari malformation (HP:0002308)1.85213862
128Zonular cataract (HP:0010920)1.84952566
129Termporal pattern (HP:0011008)1.84034826
130Insidious onset (HP:0003587)1.84034826
131Polar cataract (HP:0010696)1.82803413
132Gait ataxia (HP:0002066)1.81281787
133Neuronal loss in central nervous system (HP:0002529)1.80094840
134Hepatoblastoma (HP:0002884)1.80004353
135Apathy (HP:0000741)1.79182613
136Abnormality of macular pigmentation (HP:0008002)1.78169591
137White forelock (HP:0002211)1.77433896
138Hyperthyroidism (HP:0000836)1.76831529
139Cutaneous finger syndactyly (HP:0010554)1.76603288
140Abnormality of the corticospinal tract (HP:0002492)1.76583485
141Abnormality of the vocal cords (HP:0008777)1.75567819
142Bronchomalacia (HP:0002780)1.74626698
143Lower limb muscle weakness (HP:0007340)1.73672534
144Abnormality of dentin (HP:0010299)1.73337475
145Hypoventilation (HP:0002791)1.72403265
146Gait imbalance (HP:0002141)1.72188406
147Fair hair (HP:0002286)1.71469151
148Rhinitis (HP:0012384)1.71328136
149Exotropia (HP:0000577)1.71306576
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70513145
151Shawl scrotum (HP:0000049)1.69248108
152Onion bulb formation (HP:0003383)1.67611406
153Protrusio acetabuli (HP:0003179)1.65195584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.22270250
2NTRK34.76029441
3CASK3.33714406
4RIPK43.18416848
5MAP3K92.93843526
6MAP3K42.78430788
7LATS22.48309837
8PNCK2.32122604
9MINK12.29708053
10MAP2K72.26275229
11DAPK22.18621320
12MAP3K122.10123087
13KSR21.93841413
14MARK11.79821038
15KSR11.71722183
16PLK21.70490941
17ALK1.67753119
18MAP2K41.66373385
19NME11.62725237
20NTRK21.62194734
21RIPK11.58443189
22DAPK11.58302822
23SIK21.57011587
24CDK51.54574101
25PRPF4B1.51107746
26NTRK11.48983874
27PAK61.48924276
28MAP2K61.48674813
29BMPR21.46387120
30FES1.43483479
31GRK51.43420223
32ARAF1.42683858
33TNIK1.39525190
34PRKCG1.35367796
35MAP3K131.29478054
36CDK191.26518062
37PTK2B1.24340209
38CAMK2A1.20387788
39LMTK21.19129285
40TAOK11.17700306
41MAPK131.15941414
42CAMK2B1.15862547
43PRKD31.15086871
44CAMKK11.07233927
45OXSR11.02559720
46ICK1.01826354
47MAP3K110.99325948
48UHMK10.95593363
49RAF10.94958750
50CDK180.94549173
51CAMK1G0.92791558
52CDK140.92347545
53DYRK20.92169731
54CDK150.91169467
55FGR0.88923402
56MAP3K20.87860959
57TRIB30.83663993
58TYRO30.82228528
59PDGFRA0.82082503
60FGFR20.78568544
61CDK11A0.78417475
62SGK2230.76583511
63SGK4940.76583511
64NEK60.74073321
65BCR0.72634035
66STK110.71265522
67STK380.70818354
68SGK10.69358655
69PRKCE0.67479919
70DYRK1A0.65793903
71DMPK0.65289416
72TNK20.65218714
73CAMK10.64815565
74PTK20.60771503
75CAMK1D0.60684265
76ERBB40.59482229
77CAMK2D0.58843256
78WNK30.58091832
79PKN10.53453912
80MAP2K10.52509669
81CAMK2G0.51925810
82BRSK10.51399278
83PDK10.51346561
84CAMKK20.50980995
85PHKG20.50970011
86PHKG10.50970011
87PAK30.50250815
88PRKCZ0.49033882
89PDPK10.48896324
90PKN20.47957141
91SIK10.46699933
92FER0.46461955
93AKT30.46461150
94GRK70.45998228
95PRKCH0.45979007
96MARK20.45901604
97DDR20.44057149
98PINK10.43670176
99DYRK1B0.43299613
100RPS6KA30.42675813
101MAP3K10.42615811
102FYN0.42261909
103ROCK20.42257703
104SGK20.42122724
105STK390.42060002
106RET0.41867739
107ADRBK20.41224782
108MAPK80.40791782
109CCNB10.40627368
110CSNK1G30.40437278
111CSNK1E0.40306985
112CSNK1G20.40129148
113PRKACA0.39836274
114SIK30.39255158
115GRK60.36818642
116BRAF0.36561009
117MAPK100.36215960
118CDK30.35654371
119DAPK30.35319838
120ADRBK10.35215548
121MAPK120.35209096
122MOS0.35133019
123SGK30.34916827
124PRKCQ0.34644272
125OBSCN0.34549105
126CAMK40.31926133
127TESK10.30606550
128GSK3B0.27537098

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02142197
2Synaptic vesicle cycle_Homo sapiens_hsa047213.01352297
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87337951
4Long-term potentiation_Homo sapiens_hsa047202.84307919
5GABAergic synapse_Homo sapiens_hsa047272.81241107
6Circadian entrainment_Homo sapiens_hsa047132.78201682
7Morphine addiction_Homo sapiens_hsa050322.77678702
8Olfactory transduction_Homo sapiens_hsa047402.72615648
9Amphetamine addiction_Homo sapiens_hsa050312.67984471
10Glutamatergic synapse_Homo sapiens_hsa047242.65983050
11Salivary secretion_Homo sapiens_hsa049702.30062703
12Dopaminergic synapse_Homo sapiens_hsa047282.20737705
13Collecting duct acid secretion_Homo sapiens_hsa049662.14579227
14Taste transduction_Homo sapiens_hsa047421.97922788
15Gastric acid secretion_Homo sapiens_hsa049711.94393760
16Renin secretion_Homo sapiens_hsa049241.91120230
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90661267
18Cholinergic synapse_Homo sapiens_hsa047251.86544569
19Cocaine addiction_Homo sapiens_hsa050301.81597464
20Long-term depression_Homo sapiens_hsa047301.81441361
21Calcium signaling pathway_Homo sapiens_hsa040201.79093455
22Serotonergic synapse_Homo sapiens_hsa047261.78294239
23Insulin secretion_Homo sapiens_hsa049111.75226440
24Oxytocin signaling pathway_Homo sapiens_hsa049211.73755928
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67125895
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.65877084
27Oxidative phosphorylation_Homo sapiens_hsa001901.56534321
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53812645
29Gap junction_Homo sapiens_hsa045401.51292240
30Cardiac muscle contraction_Homo sapiens_hsa042601.45929806
31GnRH signaling pathway_Homo sapiens_hsa049121.37037178
32Alzheimers disease_Homo sapiens_hsa050101.34995027
33Vibrio cholerae infection_Homo sapiens_hsa051101.28043620
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27073423
35* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26505753
36Parkinsons disease_Homo sapiens_hsa050121.25300015
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23512923
38cAMP signaling pathway_Homo sapiens_hsa040241.18464734
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14158068
40Vitamin B6 metabolism_Homo sapiens_hsa007501.09324255
41Melanogenesis_Homo sapiens_hsa049161.06744788
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.04729772
43Phototransduction_Homo sapiens_hsa047441.03687254
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03042921
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02908730
46Axon guidance_Homo sapiens_hsa043601.01356731
47Estrogen signaling pathway_Homo sapiens_hsa049150.99539411
48Glioma_Homo sapiens_hsa052140.96204730
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92940392
50Arginine biosynthesis_Homo sapiens_hsa002200.92336930
51Arginine and proline metabolism_Homo sapiens_hsa003300.92243371
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90778386
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89899633
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87971735
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85616670
56Huntingtons disease_Homo sapiens_hsa050160.82623377
57Pancreatic secretion_Homo sapiens_hsa049720.82076060
58Biosynthesis of amino acids_Homo sapiens_hsa012300.81919007
59Dilated cardiomyopathy_Homo sapiens_hsa054140.80488523
60ErbB signaling pathway_Homo sapiens_hsa040120.79903009
61Oocyte meiosis_Homo sapiens_hsa041140.76947914
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74929316
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74690317
64Protein digestion and absorption_Homo sapiens_hsa049740.73489950
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72413159
66Thyroid hormone synthesis_Homo sapiens_hsa049180.71334681
67Type II diabetes mellitus_Homo sapiens_hsa049300.71295423
68ECM-receptor interaction_Homo sapiens_hsa045120.67821896
69Histidine metabolism_Homo sapiens_hsa003400.66778400
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66460117
71African trypanosomiasis_Homo sapiens_hsa051430.63235548
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62984926
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.62568200
74HIF-1 signaling pathway_Homo sapiens_hsa040660.62204221
75Choline metabolism in cancer_Homo sapiens_hsa052310.60934706
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.60305704
77Alcoholism_Homo sapiens_hsa050340.59512424
78Dorso-ventral axis formation_Homo sapiens_hsa043200.58776735
79Amoebiasis_Homo sapiens_hsa051460.55905930
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55756042
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54783550
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54669904
83MAPK signaling pathway_Homo sapiens_hsa040100.54300096
84Rap1 signaling pathway_Homo sapiens_hsa040150.54251689
85VEGF signaling pathway_Homo sapiens_hsa043700.52621826
86Ras signaling pathway_Homo sapiens_hsa040140.52473922
87Fructose and mannose metabolism_Homo sapiens_hsa000510.52339159
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50961930
89Glucagon signaling pathway_Homo sapiens_hsa049220.50649186
90Phenylalanine metabolism_Homo sapiens_hsa003600.48910745
91Type I diabetes mellitus_Homo sapiens_hsa049400.48903861
92Insulin signaling pathway_Homo sapiens_hsa049100.47110207
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46628140
94Rheumatoid arthritis_Homo sapiens_hsa053230.45605687
95Hedgehog signaling pathway_Homo sapiens_hsa043400.45108155
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44770189
97Prion diseases_Homo sapiens_hsa050200.43222620
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41790763
99Focal adhesion_Homo sapiens_hsa045100.41532375
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40976430
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40830531
102Ovarian steroidogenesis_Homo sapiens_hsa049130.37167126
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.35969775
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35628854
105Bile secretion_Homo sapiens_hsa049760.35099579
106Wnt signaling pathway_Homo sapiens_hsa043100.33108730
107Non-small cell lung cancer_Homo sapiens_hsa052230.30214902
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28492306
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28104546
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27586237
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27369647
112Renal cell carcinoma_Homo sapiens_hsa052110.27358798
113Phagosome_Homo sapiens_hsa041450.25808241
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25698293
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.25540793
116Endocytosis_Homo sapiens_hsa041440.24948351
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24134333
118Chemokine signaling pathway_Homo sapiens_hsa040620.22873503
119Butanoate metabolism_Homo sapiens_hsa006500.22402405
120Inositol phosphate metabolism_Homo sapiens_hsa005620.21950133
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21579703
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20354064
123Circadian rhythm_Homo sapiens_hsa047100.20078699

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