MCF2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.83489740
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.25577466
3gamma-aminobutyric acid transport (GO:0015812)4.16627218
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.86316820
5L-fucose catabolic process (GO:0042355)3.73539617
6fucose catabolic process (GO:0019317)3.73539617
7L-fucose metabolic process (GO:0042354)3.73539617
8serotonin metabolic process (GO:0042428)3.62250139
9negative regulation of cytosolic calcium ion concentration (GO:0051481)3.61511521
10indole-containing compound catabolic process (GO:0042436)3.59162083
11indolalkylamine catabolic process (GO:0046218)3.59162083
12tryptophan catabolic process (GO:0006569)3.59162083
13kynurenine metabolic process (GO:0070189)3.55914460
14indolalkylamine metabolic process (GO:0006586)3.55408902
15transmission of nerve impulse (GO:0019226)3.54687130
16neuronal action potential propagation (GO:0019227)3.52715274
17primary amino compound metabolic process (GO:1901160)3.47984958
18membrane depolarization during action potential (GO:0086010)3.46513563
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40075510
20response to pheromone (GO:0019236)3.37195135
21proline transport (GO:0015824)3.31572822
22indole-containing compound metabolic process (GO:0042430)3.29998902
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29686971
24negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25533697
25axon ensheathment in central nervous system (GO:0032291)3.23805290
26central nervous system myelination (GO:0022010)3.23805290
27cellular ketone body metabolic process (GO:0046950)3.21947293
28neuronal action potential (GO:0019228)3.19997056
29detection of light stimulus involved in sensory perception (GO:0050962)3.16184682
30detection of light stimulus involved in visual perception (GO:0050908)3.16184682
31tryptophan metabolic process (GO:0006568)3.12331476
32behavioral response to ethanol (GO:0048149)3.11701960
33startle response (GO:0001964)3.10020136
34postsynaptic membrane organization (GO:0001941)3.09643818
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07716391
36glutamate receptor signaling pathway (GO:0007215)3.06780766
37reflex (GO:0060004)3.06149204
38synaptic transmission, glutamatergic (GO:0035249)3.05742218
39ionotropic glutamate receptor signaling pathway (GO:0035235)2.97922339
40retinal cone cell development (GO:0046549)2.97276833
41synaptic vesicle docking involved in exocytosis (GO:0016081)2.93042950
42protein K11-linked deubiquitination (GO:0035871)2.88737380
43presynaptic membrane assembly (GO:0097105)2.87638014
44cilium or flagellum-dependent cell motility (GO:0001539)2.86918706
45ketone body metabolic process (GO:1902224)2.86771374
46gamma-aminobutyric acid signaling pathway (GO:0007214)2.86051990
47auditory receptor cell stereocilium organization (GO:0060088)2.85759035
48synaptic vesicle maturation (GO:0016188)2.82526891
49sulfation (GO:0051923)2.81880273
50nonmotile primary cilium assembly (GO:0035058)2.81524120
51protein localization to synapse (GO:0035418)2.80659036
52regulation of neurotransmitter uptake (GO:0051580)2.79931108
53potassium ion transmembrane transport (GO:0071805)2.76232390
54cellular potassium ion transport (GO:0071804)2.76232390
55epithelial cilium movement (GO:0003351)2.74655768
56detection of mechanical stimulus involved in sensory perception (GO:0050974)2.74056576
57cAMP catabolic process (GO:0006198)2.71770797
58vocalization behavior (GO:0071625)2.71540685
59neuron-neuron synaptic transmission (GO:0007270)2.71313688
60dendritic spine morphogenesis (GO:0060997)2.71019208
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69993432
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68968055
63axoneme assembly (GO:0035082)2.65039625
64neuron cell-cell adhesion (GO:0007158)2.64854396
65presynaptic membrane organization (GO:0097090)2.64691318
66neuromuscular synaptic transmission (GO:0007274)2.64520037
67protein polyglutamylation (GO:0018095)2.63120286
68regulation of hippo signaling (GO:0035330)2.62634338
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62111778
70positive regulation of sodium ion transmembrane transport (GO:1902307)2.61772662
71photoreceptor cell maintenance (GO:0045494)2.61758092
72inner ear receptor stereocilium organization (GO:0060122)2.61021583
73potassium ion transport (GO:0006813)2.59315529
74action potential (GO:0001508)2.58682864
75regulation of action potential (GO:0098900)2.58024678
76positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.57968893
77cyclic nucleotide catabolic process (GO:0009214)2.57907336
78auditory behavior (GO:0031223)2.56959807
79neural tube formation (GO:0001841)2.54849052
80alanine transport (GO:0032328)2.51943805
81cilium movement (GO:0003341)2.51450391
82regulation of translation, ncRNA-mediated (GO:0045974)2.50514715
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50514715
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.50514715
85regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47669189
86protein localization to cilium (GO:0061512)2.46692292
87nephron tubule morphogenesis (GO:0072078)2.46026302
88nephron epithelium morphogenesis (GO:0072088)2.46026302
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45716320
90NAD biosynthetic process (GO:0009435)2.45194300
91regulation of posttranscriptional gene silencing (GO:0060147)2.44710531
92regulation of gene silencing by miRNA (GO:0060964)2.44710531
93regulation of gene silencing by RNA (GO:0060966)2.44710531
94cerebellar Purkinje cell differentiation (GO:0021702)2.44498742
95membrane depolarization (GO:0051899)2.44363243
96C4-dicarboxylate transport (GO:0015740)2.44283083
97cellular response to ATP (GO:0071318)2.41730827
98rhodopsin mediated signaling pathway (GO:0016056)2.41339263
99signal peptide processing (GO:0006465)2.40403803
100adaptation of signaling pathway (GO:0023058)2.40029499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04655497
2GBX2_23144817_ChIP-Seq_PC3_Human3.54622504
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00437780
4VDR_22108803_ChIP-Seq_LS180_Human2.89554420
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61840686
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61193962
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60631110
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37577738
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11826591
10IGF1R_20145208_ChIP-Seq_DFB_Human2.10703806
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09405752
12TAF15_26573619_Chip-Seq_HEK293_Human2.05753855
13* P300_19829295_ChIP-Seq_ESCs_Human2.00821173
14REST_21632747_ChIP-Seq_MESCs_Mouse1.96982807
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94222876
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.93850842
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91946828
18FUS_26573619_Chip-Seq_HEK293_Human1.81731495
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79912802
20ER_23166858_ChIP-Seq_MCF-7_Human1.73706529
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.72872788
22DROSHA_22980978_ChIP-Seq_HELA_Human1.71649657
23EWS_26573619_Chip-Seq_HEK293_Human1.70381202
24* STAT3_23295773_ChIP-Seq_U87_Human1.69986005
25SMAD4_21799915_ChIP-Seq_A2780_Human1.68748481
26AR_21572438_ChIP-Seq_LNCaP_Human1.68589580
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66478234
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62235067
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59352351
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58626395
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58144283
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57443751
33* TCF4_23295773_ChIP-Seq_U87_Human1.57008731
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56361915
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56038362
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56038362
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54181315
38AR_25329375_ChIP-Seq_VCAP_Human1.52519898
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52381320
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.52038369
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50067396
42BCAT_22108803_ChIP-Seq_LS180_Human1.50040774
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.47602343
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44251701
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44085297
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41527467
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40764564
48CBP_20019798_ChIP-Seq_JUKART_Human1.40764564
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39697710
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38375933
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.37093855
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36439459
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36124182
54RNF2_27304074_Chip-Seq_NSC_Mouse1.32537408
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29720350
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28892986
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.28813395
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.28264346
59RUNX2_22187159_ChIP-Seq_PCA_Human1.27963594
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.27341006
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25925416
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25246341
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.24708860
64* TCF4_22108803_ChIP-Seq_LS180_Human1.24298085
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.24157488
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23391174
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.22194550
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18940387
69TP53_22573176_ChIP-Seq_HFKS_Human1.18587367
70* NANOG_19829295_ChIP-Seq_ESCs_Human1.18462156
71* SOX2_19829295_ChIP-Seq_ESCs_Human1.18462156
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17935655
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17845553
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.17310521
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.17003386
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16151278
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.16119471
78IRF1_19129219_ChIP-ChIP_H3396_Human1.14770899
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14321320
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14002731
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13800970
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.12255917
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12231984
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11612311
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10749375
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10151041
87TP53_16413492_ChIP-PET_HCT116_Human1.09673010
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.08725231
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.08713636
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08434183
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07685712
92ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07537748
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05246769
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05080398
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04041200
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.04041200
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03480351
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03338944
99KDM2B_26808549_Chip-Seq_REH_Human1.03106585
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.02555091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.95538544
2MP0009046_muscle_twitch2.89426882
3MP0009745_abnormal_behavioral_response2.82258665
4MP0001968_abnormal_touch/_nociception2.72267276
5MP0000569_abnormal_digit_pigmentation2.69638339
6MP0001501_abnormal_sleep_pattern2.51413714
7MP0002272_abnormal_nervous_system2.44403796
8MP0005551_abnormal_eye_electrophysiolog2.44400420
9MP0002064_seizures2.42010499
10MP0001486_abnormal_startle_reflex2.40658122
11MP0003195_calcinosis2.39333352
12MP0003635_abnormal_synaptic_transmissio2.30907592
13MP0004859_abnormal_synaptic_plasticity2.18583164
14MP0002736_abnormal_nociception_after2.16985096
15MP0008877_abnormal_DNA_methylation2.14072791
16MP0001485_abnormal_pinna_reflex2.09580653
17MP0002572_abnormal_emotion/affect_behav2.08369824
18MP0005423_abnormal_somatic_nervous2.03217053
19MP0002735_abnormal_chemical_nociception1.99495207
20MP0004885_abnormal_endolymph1.98955011
21MP0005646_abnormal_pituitary_gland1.95905578
22MP0002063_abnormal_learning/memory/cond1.93369512
23MP0002102_abnormal_ear_morphology1.85335797
24MP0004142_abnormal_muscle_tone1.84267489
25MP0003136_yellow_coat_color1.82970470
26MP0006276_abnormal_autonomic_nervous1.79599763
27MP0002734_abnormal_mechanical_nocicepti1.78446508
28MP0003646_muscle_fatigue1.78134006
29MP0003787_abnormal_imprinting1.76446950
30MP0002638_abnormal_pupillary_reflex1.76299219
31MP0004147_increased_porphyrin_level1.75891411
32MP0001970_abnormal_pain_threshold1.70320328
33MP0004043_abnormal_pH_regulation1.69874269
34MP0002733_abnormal_thermal_nociception1.65960311
35MP0008872_abnormal_physiological_respon1.65930401
36MP0002067_abnormal_sensory_capabilities1.64950631
37MP0001984_abnormal_olfaction1.62631408
38MP0002557_abnormal_social/conspecific_i1.61914296
39MP0002653_abnormal_ependyma_morphology1.57666604
40MP0004270_analgesia1.55639086
41MP0005645_abnormal_hypothalamus_physiol1.54371541
42MP0001986_abnormal_taste_sensitivity1.54296592
43MP0005253_abnormal_eye_physiology1.54122230
44MP0004145_abnormal_muscle_electrophysio1.50861284
45MP0002837_dystrophic_cardiac_calcinosis1.48903085
46MP0004742_abnormal_vestibular_system1.48701191
47MP0006072_abnormal_retinal_apoptosis1.48453846
48MP0004924_abnormal_behavior1.47149578
49MP0005386_behavior/neurological_phenoty1.47149578
50MP0005377_hearing/vestibular/ear_phenot1.38205767
51MP0003878_abnormal_ear_physiology1.38205767
52MP0000427_abnormal_hair_cycle1.37952772
53MP0004133_heterotaxia1.35978922
54MP0000631_abnormal_neuroendocrine_gland1.35005046
55MP0002876_abnormal_thyroid_physiology1.32694065
56MP0000778_abnormal_nervous_system1.24424042
57MP0001905_abnormal_dopamine_level1.21842661
58MP0005174_abnormal_tail_pigmentation1.20557248
59MP0003879_abnormal_hair_cell1.20432816
60MP0006292_abnormal_olfactory_placode1.19545754
61MP0010386_abnormal_urinary_bladder1.16164635
62MP0003890_abnormal_embryonic-extraembry1.16139762
63MP0002229_neurodegeneration1.13931533
64MP0005167_abnormal_blood-brain_barrier1.13619089
65MP0001529_abnormal_vocalization1.12022970
66MP0001963_abnormal_hearing_physiology1.10439542
67MP0001440_abnormal_grooming_behavior1.08701646
68MP0003633_abnormal_nervous_system1.07341610
69MP0002938_white_spotting1.06708605
70MP0003283_abnormal_digestive_organ1.06252098
71MP0002882_abnormal_neuron_morphology1.05440558
72MP0002184_abnormal_innervation1.04553552
73MP0008875_abnormal_xenobiotic_pharmacok1.01612971
74MP0000955_abnormal_spinal_cord1.00580433
75MP0004215_abnormal_myocardial_fiber0.98151585
76MP0003137_abnormal_impulse_conducting0.97978150
77MP0001502_abnormal_circadian_rhythm0.97716312
78MP0002928_abnormal_bile_duct0.97714268
79MP0002752_abnormal_somatic_nervous0.97583818
80MP0000026_abnormal_inner_ear0.96615461
81MP0002909_abnormal_adrenal_gland0.92571766
82MP0008569_lethality_at_weaning0.91067270
83MP0002066_abnormal_motor_capabilities/c0.90145962
84MP0004130_abnormal_muscle_cell0.89721604
85MP0002234_abnormal_pharynx_morphology0.89097109
86MP0005195_abnormal_posterior_eye0.88929448
87MP0003011_delayed_dark_adaptation0.88196493
88MP0003631_nervous_system_phenotype0.87596777
89MP0000383_abnormal_hair_follicle0.84773247
90MP0000230_abnormal_systemic_arterial0.83782367
91MP0003119_abnormal_digestive_system0.83490346
92MP0004085_abnormal_heartbeat0.83423818
93MP0005410_abnormal_fertilization0.82174621
94MP0003698_abnormal_male_reproductive0.78977172
95MP0000372_irregular_coat_pigmentation0.76828058
96MP0002160_abnormal_reproductive_system0.76442945
97MP0002822_catalepsy0.75559031
98MP0002152_abnormal_brain_morphology0.72515608
99MP0002095_abnormal_skin_pigmentation0.70350254
100MP0003122_maternal_imprinting0.69581081

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.22880301
2Congenital stationary night blindness (HP:0007642)3.93225086
3Molar tooth sign on MRI (HP:0002419)3.86928203
4Abnormality of midbrain morphology (HP:0002418)3.86928203
5Hyperventilation (HP:0002883)3.86790766
6Pancreatic fibrosis (HP:0100732)3.85941956
7True hermaphroditism (HP:0010459)3.70159930
8Progressive cerebellar ataxia (HP:0002073)3.68099247
9Focal motor seizures (HP:0011153)3.58591025
10Febrile seizures (HP:0002373)3.47549429
11Genetic anticipation (HP:0003743)3.39479987
12Nephronophthisis (HP:0000090)3.35392452
13Gaze-evoked nystagmus (HP:0000640)3.35384806
14Focal seizures (HP:0007359)3.17897398
15Type II lissencephaly (HP:0007260)3.11446053
16Abnormality of the renal cortex (HP:0011035)3.09807128
17Attenuation of retinal blood vessels (HP:0007843)3.04703941
18Abnormality of the renal medulla (HP:0100957)2.99625444
19Medial flaring of the eyebrow (HP:0010747)2.89471933
20Inability to walk (HP:0002540)2.81954644
21Protruding tongue (HP:0010808)2.78894041
22Polydipsia (HP:0001959)2.78337933
23Abnormal drinking behavior (HP:0030082)2.78337933
24Broad-based gait (HP:0002136)2.77751577
25Cystic liver disease (HP:0006706)2.77568328
26Chronic hepatic failure (HP:0100626)2.75868912
27Abnormality of alanine metabolism (HP:0010916)2.65991814
28Hyperalaninemia (HP:0003348)2.65991814
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65991814
30Dialeptic seizures (HP:0011146)2.65475512
31Progressive inability to walk (HP:0002505)2.61362053
32Abolished electroretinogram (ERG) (HP:0000550)2.57963090
33Large for gestational age (HP:0001520)2.57711541
34Decreased circulating renin level (HP:0003351)2.55492630
35Gait imbalance (HP:0002141)2.52952904
36Epileptic encephalopathy (HP:0200134)2.49236113
37Tubular atrophy (HP:0000092)2.48181377
38Hemiparesis (HP:0001269)2.43511553
39Absent speech (HP:0001344)2.42098092
40Clumsiness (HP:0002312)2.41199273
41Atonic seizures (HP:0010819)2.38233212
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.37359710
43Absent/shortened dynein arms (HP:0200106)2.37359710
44Absence seizures (HP:0002121)2.32720271
45Congenital primary aphakia (HP:0007707)2.28044731
46Cerebellar dysplasia (HP:0007033)2.26271614
47Sclerocornea (HP:0000647)2.25775902
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.23458175
49Lissencephaly (HP:0001339)2.18467479
50Polyuria (HP:0000103)2.18216892
51Furrowed tongue (HP:0000221)2.17337773
52Myokymia (HP:0002411)2.13938722
53Pendular nystagmus (HP:0012043)2.12431310
54Decreased central vision (HP:0007663)2.11686019
55Genital tract atresia (HP:0001827)2.10769062
56Bony spicule pigmentary retinopathy (HP:0007737)2.09356061
57Nephrogenic diabetes insipidus (HP:0009806)2.09255622
58Keratoconus (HP:0000563)2.07729808
59Increased corneal curvature (HP:0100692)2.07729808
60Abnormal rod and cone electroretinograms (HP:0008323)2.07084393
61Optic nerve hypoplasia (HP:0000609)2.05471373
62Vaginal atresia (HP:0000148)2.05462831
63Fair hair (HP:0002286)2.04759332
64Congenital, generalized hypertrichosis (HP:0004540)2.02687484
65Renal cortical cysts (HP:0000803)2.02540166
66Abnormality of binocular vision (HP:0011514)2.02039727
67Diplopia (HP:0000651)2.02039727
68Stomach cancer (HP:0012126)2.01231163
69Birth length less than 3rd percentile (HP:0003561)1.99420575
70Congenital hepatic fibrosis (HP:0002612)1.97990939
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97957735
72Anencephaly (HP:0002323)1.97811053
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.96817561
74Generalized tonic-clonic seizures (HP:0002069)1.96377405
75Bile duct proliferation (HP:0001408)1.94752041
76Abnormal biliary tract physiology (HP:0012439)1.94752041
77Congenital sensorineural hearing impairment (HP:0008527)1.94619791
78Abnormal ciliary motility (HP:0012262)1.93395870
79Drooling (HP:0002307)1.91137469
80Male pseudohermaphroditism (HP:0000037)1.90848290
81Abnormal respiratory motile cilium morphology (HP:0005938)1.90422317
82Abnormal respiratory epithelium morphology (HP:0012253)1.90422317
83Poor coordination (HP:0002370)1.88328821
84Epileptiform EEG discharges (HP:0011182)1.87687093
85Limb dystonia (HP:0002451)1.86782824
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86710702
87Widely spaced teeth (HP:0000687)1.81267115
88Chorioretinal atrophy (HP:0000533)1.80180322
89Abnormality of the pons (HP:0007361)1.79239306
90Patellar aplasia (HP:0006443)1.78897085
91Retinal dysplasia (HP:0007973)1.78734499
92Abnormality of renin-angiotensin system (HP:0000847)1.78307958
93Hypoplasia of the pons (HP:0012110)1.75050658
94EEG with generalized epileptiform discharges (HP:0011198)1.74297523
95Severe muscular hypotonia (HP:0006829)1.74030577
96Hemiplegia (HP:0002301)1.73066223
97Abnormal urine output (HP:0012590)1.72331139
98Prolonged QT interval (HP:0001657)1.71805062
99Abnormality of macular pigmentation (HP:0008002)1.71467025
100Hypsarrhythmia (HP:0002521)1.70972833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.82161973
2BMPR1B3.30371398
3ACVR1B2.89574137
4ADRBK22.82375432
5CASK2.59362326
6INSRR2.54998509
7NTRK32.41022820
8WNK32.31808347
9PINK12.24142729
10GRK12.15335988
11MAPK132.07375258
12DAPK22.06983984
13ZAK1.97913245
14MARK11.94853799
15WNK41.86680262
16EPHA41.77761522
17MAP4K21.76581328
18MAP3K41.76478135
19OXSR11.75343450
20TAOK31.71037269
21NUAK11.53027493
22TLK11.46384668
23STK391.44640847
24CAMKK21.41731472
25TNIK1.41335404
26NTRK21.34931564
27PRKCG1.27810854
28ADRBK11.24090420
29PAK31.21415914
30MKNK21.19740574
31PNCK1.19248589
32PLK21.10609668
33TXK1.09785096
34TGFBR11.02813729
35CAMK1D0.99524556
36SIK20.95562162
37CAMK10.95278358
38STK38L0.94039103
39CAMKK10.93358263
40PRKCE0.91323477
41PHKG10.91086760
42PHKG20.91086760
43CAMK1G0.85067635
44PAK60.83046599
45MAP2K70.80096489
46CAMK2A0.80089475
47PIK3CA0.76787508
48STK110.75018522
49PTK2B0.74704975
50AKT30.74172066
51DYRK20.72100667
52FGFR20.71673321
53SGK20.69204774
54PKN10.68077972
55CSNK1G20.62400642
56OBSCN0.62144440
57SGK2230.61628631
58SGK4940.61628631
59MAPKAPK50.60388269
60MUSK0.57274622
61GRK50.57175541
62TIE10.56044733
63MAPK150.55488962
64TNK20.54199440
65PRKCH0.53360652
66STK380.53323445
67CAMK40.50194650
68CDK50.50158242
69PRKACA0.48170290
70PRKCQ0.47477730
71MINK10.47020520
72DYRK1A0.46868754
73MAP2K60.46181879
74MAPKAPK30.45000722
75SGK10.44982012
76PRKAA20.44294450
77CDK190.43527436
78CSNK1G10.42390618
79BRSK20.42188653
80WNK10.42045099
81PLK40.41845213
82TEC0.41771293
83NLK0.41739797
84PRKAA10.41529778
85CAMK2B0.40500368
86PRKCA0.40151152
87ERBB20.39994519
88CSNK1A10.39707347
89CSNK1D0.39499349
90PRKG10.39281129
91UHMK10.38232092
92PRKCZ0.38062386
93MAP2K10.35214747
94RPS6KA50.34398243
95TRIM280.33199405
96RPS6KA30.32831326
97NEK20.31784336
98IRAK10.31533165
99CSNK1A1L0.30828637
100MAP3K70.30584707

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82152430
2Phototransduction_Homo sapiens_hsa047442.83745948
3Butanoate metabolism_Homo sapiens_hsa006502.39410974
4Morphine addiction_Homo sapiens_hsa050322.37071178
5Nitrogen metabolism_Homo sapiens_hsa009102.24877747
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.23522116
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18870426
8Linoleic acid metabolism_Homo sapiens_hsa005912.16756247
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14426613
10Circadian entrainment_Homo sapiens_hsa047132.11619650
11GABAergic synapse_Homo sapiens_hsa047272.05729355
12Glutamatergic synapse_Homo sapiens_hsa047242.01688599
13Insulin secretion_Homo sapiens_hsa049111.98796935
14Taste transduction_Homo sapiens_hsa047421.97953276
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97464095
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82354711
17Tryptophan metabolism_Homo sapiens_hsa003801.78586023
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74140268
19Olfactory transduction_Homo sapiens_hsa047401.71346599
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68451747
21Selenocompound metabolism_Homo sapiens_hsa004501.62954673
22Ether lipid metabolism_Homo sapiens_hsa005651.57182171
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.56993946
24Serotonergic synapse_Homo sapiens_hsa047261.50401905
25ABC transporters_Homo sapiens_hsa020101.50301961
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48414989
27Salivary secretion_Homo sapiens_hsa049701.46602425
28Calcium signaling pathway_Homo sapiens_hsa040201.39387741
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38418407
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37518254
31Dopaminergic synapse_Homo sapiens_hsa047281.32275228
32Amphetamine addiction_Homo sapiens_hsa050311.31428588
33Gastric acid secretion_Homo sapiens_hsa049711.25372531
34Cardiac muscle contraction_Homo sapiens_hsa042601.22000676
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.19770374
36Ovarian steroidogenesis_Homo sapiens_hsa049131.18840862
37Oxidative phosphorylation_Homo sapiens_hsa001901.17721921
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.15675818
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15095755
40Cholinergic synapse_Homo sapiens_hsa047251.14508792
41Cocaine addiction_Homo sapiens_hsa050301.14048000
42Synaptic vesicle cycle_Homo sapiens_hsa047211.13865467
43Homologous recombination_Homo sapiens_hsa034401.12437332
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11781093
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05829333
46Caffeine metabolism_Homo sapiens_hsa002321.03398799
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00274644
48Oxytocin signaling pathway_Homo sapiens_hsa049210.99744187
49cAMP signaling pathway_Homo sapiens_hsa040240.98652528
50Dorso-ventral axis formation_Homo sapiens_hsa043200.98558771
51Long-term depression_Homo sapiens_hsa047300.97594328
52Histidine metabolism_Homo sapiens_hsa003400.93354615
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92369252
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.91232324
55Propanoate metabolism_Homo sapiens_hsa006400.91025685
56Fanconi anemia pathway_Homo sapiens_hsa034600.89485264
57Glycerolipid metabolism_Homo sapiens_hsa005610.86852431
58Chemical carcinogenesis_Homo sapiens_hsa052040.85871918
59beta-Alanine metabolism_Homo sapiens_hsa004100.85219071
60Renin secretion_Homo sapiens_hsa049240.80507683
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78836711
62Parkinsons disease_Homo sapiens_hsa050120.78664929
63Basal transcription factors_Homo sapiens_hsa030220.76887627
64Arachidonic acid metabolism_Homo sapiens_hsa005900.75676909
65Retinol metabolism_Homo sapiens_hsa008300.75439722
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73849159
67Circadian rhythm_Homo sapiens_hsa047100.73070413
68Fatty acid biosynthesis_Homo sapiens_hsa000610.71892724
69Peroxisome_Homo sapiens_hsa041460.68824799
70Mineral absorption_Homo sapiens_hsa049780.67591510
71Alzheimers disease_Homo sapiens_hsa050100.66574182
72Pancreatic secretion_Homo sapiens_hsa049720.66434047
73Bile secretion_Homo sapiens_hsa049760.65058297
74RNA polymerase_Homo sapiens_hsa030200.62716023
75Huntingtons disease_Homo sapiens_hsa050160.60987736
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60665537
77Collecting duct acid secretion_Homo sapiens_hsa049660.59736109
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58160901
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56763797
80Type II diabetes mellitus_Homo sapiens_hsa049300.56698500
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56100547
82Regulation of autophagy_Homo sapiens_hsa041400.55896480
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.54147663
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51648623
85Protein export_Homo sapiens_hsa030600.50159029
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47092516
87Fat digestion and absorption_Homo sapiens_hsa049750.46073126
88One carbon pool by folate_Homo sapiens_hsa006700.43879906
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40661476
90Thyroid hormone synthesis_Homo sapiens_hsa049180.40188865
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.39184323
92Long-term potentiation_Homo sapiens_hsa047200.37745058
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37272664
94RNA degradation_Homo sapiens_hsa030180.36207828
95Fatty acid degradation_Homo sapiens_hsa000710.35030373
96Hedgehog signaling pathway_Homo sapiens_hsa043400.34122365
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31577248
98Ras signaling pathway_Homo sapiens_hsa040140.31225238
99Purine metabolism_Homo sapiens_hsa002300.30140927
100Metabolic pathways_Homo sapiens_hsa011000.29952579

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