MCF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.18872263
2gamma-aminobutyric acid transport (GO:0015812)5.11550463
3regulation of gene silencing by miRNA (GO:0060964)5.06357914
4regulation of gene silencing by RNA (GO:0060966)5.06357914
5regulation of posttranscriptional gene silencing (GO:0060147)5.06357914
6neuronal action potential propagation (GO:0019227)4.92759536
7vocalization behavior (GO:0071625)4.86416457
8synaptic vesicle maturation (GO:0016188)4.69527237
9somatic hypermutation of immunoglobulin genes (GO:0016446)4.67553620
10somatic diversification of immune receptors via somatic mutation (GO:0002566)4.67553620
11mitotic sister chromatid segregation (GO:0000070)4.62398618
12DNA replication-dependent nucleosome organization (GO:0034723)4.61067402
13DNA replication-dependent nucleosome assembly (GO:0006335)4.61067402
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.57954436
15protein localization to kinetochore (GO:0034501)4.57269581
16establishment of mitochondrion localization (GO:0051654)4.48375326
17glutamate secretion (GO:0014047)4.45090029
18nuclear pore organization (GO:0006999)4.35454715
19neuron cell-cell adhesion (GO:0007158)4.34349715
20DNA replication initiation (GO:0006270)4.33072168
21nucleobase catabolic process (GO:0046113)4.32879695
22regulation of helicase activity (GO:0051095)4.32681069
23presynaptic membrane assembly (GO:0097105)4.30249465
24histone arginine methylation (GO:0034969)4.29674312
25formation of translation preinitiation complex (GO:0001731)4.19427599
26histone H4-K12 acetylation (GO:0043983)4.18845470
27nuclear pore complex assembly (GO:0051292)4.16569642
28synaptic vesicle exocytosis (GO:0016079)4.16473241
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.10946869
30determination of adult lifespan (GO:0008340)4.08808276
31presynaptic membrane organization (GO:0097090)3.98754091
32mitotic metaphase plate congression (GO:0007080)3.96758241
33postsynaptic membrane organization (GO:0001941)3.94739814
34ribosome biogenesis (GO:0042254)3.94661611
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94269334
36neurotransmitter secretion (GO:0007269)3.92595254
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.90413953
38neuronal ion channel clustering (GO:0045161)3.89206612
39regulation of synaptic vesicle exocytosis (GO:2000300)3.88747946
40sister chromatid segregation (GO:0000819)3.88458266
41neurotransmitter-gated ion channel clustering (GO:0072578)3.84898164
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.79749060
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79242972
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78887768
45neuron-neuron synaptic transmission (GO:0007270)3.78004333
46histone H4-K5 acetylation (GO:0043981)3.77903811
47histone H4-K8 acetylation (GO:0043982)3.77903811
48DNA unwinding involved in DNA replication (GO:0006268)3.76343676
49synaptic transmission, glutamatergic (GO:0035249)3.74525865
50DNA replication checkpoint (GO:0000076)3.73701664
51pre-miRNA processing (GO:0031054)3.71197388
52regulation of synaptic vesicle transport (GO:1902803)3.70710494
53mitochondrion transport along microtubule (GO:0047497)3.67847898
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.67847898
55nucleobase biosynthetic process (GO:0046112)3.66814832
56response to histamine (GO:0034776)3.66725809
57regulation of telomere maintenance via telomerase (GO:0032210)3.66346277
58regulation of synapse structural plasticity (GO:0051823)3.63788449
59mitotic nuclear envelope disassembly (GO:0007077)3.59742820
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57416862
61protein localization to chromosome, centromeric region (GO:0071459)3.57248031
62heterochromatin organization (GO:0070828)3.56698014
63peptidyl-arginine omega-N-methylation (GO:0035247)3.54889328
64anterior/posterior axis specification, embryo (GO:0008595)3.54421650
65DNA strand elongation involved in DNA replication (GO:0006271)3.54413525
66cullin deneddylation (GO:0010388)3.49880505
67IMP biosynthetic process (GO:0006188)3.49340703
68purine nucleobase biosynthetic process (GO:0009113)3.48108208
69folic acid-containing compound biosynthetic process (GO:0009396)3.47460372
70replication fork processing (GO:0031297)3.46857421
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.45498290
72synaptic vesicle docking involved in exocytosis (GO:0016081)3.45481510
73negative regulation of histone methylation (GO:0031061)3.45217517
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.44682968
75protein localization to synapse (GO:0035418)3.43026165
76DNA duplex unwinding (GO:0032508)3.40983000
77DNA geometric change (GO:0032392)3.40462096
78glutamate receptor signaling pathway (GO:0007215)3.40061118
79membrane disassembly (GO:0030397)3.38809225
80nuclear envelope disassembly (GO:0051081)3.38809225
81neurofilament cytoskeleton organization (GO:0060052)3.36311075
82negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.35603771
83melanin biosynthetic process (GO:0042438)3.34934024
84negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.33376018
85DNA strand elongation (GO:0022616)3.33086315
86regulation of histone H3-K9 methylation (GO:0051570)3.31847485
87metaphase plate congression (GO:0051310)3.30129164
88behavioral response to cocaine (GO:0048148)3.29803037
89ribosome assembly (GO:0042255)3.27479629
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25437778
91transmission of nerve impulse (GO:0019226)3.24501043
92regulation of vesicle fusion (GO:0031338)3.24051955
93neurotransmitter transport (GO:0006836)3.22325971
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17852193
95neuron recognition (GO:0008038)3.17512739
96ribonucleoprotein complex biogenesis (GO:0022613)3.16456933
97regulation of translational fidelity (GO:0006450)3.16267893
98maturation of 5.8S rRNA (GO:0000460)3.16042446
99negative regulation of androgen receptor signaling pathway (GO:0060766)3.14785698
100telomere maintenance via semi-conservative replication (GO:0032201)3.14704861
101regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14422644
102auditory behavior (GO:0031223)3.12201422
103protein deneddylation (GO:0000338)3.11849041
104melanin metabolic process (GO:0006582)3.11541612
105peptidyl-arginine methylation (GO:0018216)3.10970265
106peptidyl-arginine N-methylation (GO:0035246)3.10970265
107regulation of voltage-gated calcium channel activity (GO:1901385)3.10688475
108regulation of double-strand break repair via homologous recombination (GO:0010569)3.10498534
109secondary metabolite biosynthetic process (GO:0044550)3.10490404
110dendrite morphogenesis (GO:0048813)3.10382289
111regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09901510
112C4-dicarboxylate transport (GO:0015740)3.09523992
113rRNA modification (GO:0000154)3.09161867
114regulation of glutamate secretion (GO:0014048)3.08354456
115regulation of neurotransmitter levels (GO:0001505)3.06364802
116positive regulation of chromosome segregation (GO:0051984)3.05213458
117startle response (GO:0001964)3.04223538
118IMP metabolic process (GO:0046040)3.04184959
119detection of calcium ion (GO:0005513)3.03623859
120central nervous system projection neuron axonogenesis (GO:0021952)3.01514828
121regulation of neurotransmitter uptake (GO:0051580)3.01232643
122cerebral cortex radially oriented cell migration (GO:0021799)3.00852801
123negative regulation of telomere maintenance (GO:0032205)3.00219519
124pore complex assembly (GO:0046931)2.99739792
125serotonin metabolic process (GO:0042428)2.99301753
126regulation of neurotransmitter secretion (GO:0046928)2.98852283
127establishment of integrated proviral latency (GO:0075713)2.98723808
128negative regulation of telomerase activity (GO:0051974)2.98452323
129negative regulation of microtubule polymerization (GO:0031115)2.97230168
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97183012
131mitotic chromosome condensation (GO:0007076)2.96900544
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96757925
133transcription from mitochondrial promoter (GO:0006390)2.96615935
134chromatin assembly (GO:0031497)2.96513188
135axonal fasciculation (GO:0007413)2.95805404
136regulation of centrosome cycle (GO:0046605)2.94679682
137exploration behavior (GO:0035640)2.94490468
138adult walking behavior (GO:0007628)2.94158176
139regulation of double-strand break repair (GO:2000779)2.92546588
140glycosphingolipid biosynthetic process (GO:0006688)2.91423642
141negative regulation of chromosome segregation (GO:0051985)2.90753868
142regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89985942
143regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89027291
144regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89027291
145nodal signaling pathway (GO:0038092)2.88247453
146synaptic vesicle endocytosis (GO:0048488)2.86991498
147chromatin remodeling at centromere (GO:0031055)2.86443174
148meiotic chromosome segregation (GO:0045132)2.86162033
149positive regulation of amino acid transport (GO:0051957)2.86037016
150mismatch repair (GO:0006298)2.85852474
151mitochondrial DNA metabolic process (GO:0032042)2.85477471
152attachment of spindle microtubules to kinetochore (GO:0008608)2.84598304
153regulation of chromosome segregation (GO:0051983)2.84225419
154glial cell proliferation (GO:0014009)2.83607998
155regulation of cAMP-dependent protein kinase activity (GO:2000479)2.83479891
156regulation of spindle organization (GO:0090224)2.83413509
157regulation of sister chromatid cohesion (GO:0007063)2.83324771
158membrane depolarization during action potential (GO:0086010)2.82858374
159neurotransmitter uptake (GO:0001504)2.82622536
160rRNA processing (GO:0006364)2.82519092
161regulation of translation in response to stress (GO:0043555)2.82133035
162neuromuscular synaptic transmission (GO:0007274)2.81867910
163regulation of gene silencing (GO:0060968)2.81023997
164locomotory exploration behavior (GO:0035641)2.80736284
165pseudouridine synthesis (GO:0001522)2.80182056
166regulation of neurotransmitter transport (GO:0051588)2.79538828
167embryonic process involved in female pregnancy (GO:0060136)2.79349802
168spliceosomal snRNP assembly (GO:0000387)2.78592329
169telomere maintenance via telomere lengthening (GO:0010833)2.77898169
170establishment of chromosome localization (GO:0051303)2.76424180
171regulation of postsynaptic membrane potential (GO:0060078)2.76325047
172establishment of apical/basal cell polarity (GO:0035089)2.76317649
173regulation of amino acid transport (GO:0051955)2.74327234
174positive regulation of SMAD protein import into nucleus (GO:0060391)2.73989870
175protein K6-linked ubiquitination (GO:0085020)2.73944434
176regulation of glutamate receptor signaling pathway (GO:1900449)2.73587827
177protein complex localization (GO:0031503)2.73533335
178rRNA metabolic process (GO:0016072)2.73269502
179nucleotide-excision repair, DNA gap filling (GO:0006297)2.73212400
180DNA damage response, detection of DNA damage (GO:0042769)2.73183745
181regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73060407
182cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.72462032
183maturation of SSU-rRNA (GO:0030490)2.72059026
184cell migration in hindbrain (GO:0021535)2.71869352
185DNA double-strand break processing (GO:0000729)2.71435964
186positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71425605
187positive regulation of synapse assembly (GO:0051965)2.71398197
188response to auditory stimulus (GO:0010996)2.70592851
189positive regulation of membrane potential (GO:0045838)2.70293494
190positive regulation of vesicle fusion (GO:0031340)2.70073934
191regulation of neuronal synaptic plasticity (GO:0048168)2.70058833
192negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68835435
193hippocampus development (GO:0021766)2.68449194
194primary amino compound metabolic process (GO:1901160)2.67975165
195synaptic vesicle transport (GO:0048489)2.67364468
196establishment of synaptic vesicle localization (GO:0097480)2.67364468
197membrane depolarization (GO:0051899)2.64642225
198regulation of dendritic spine morphogenesis (GO:0061001)2.63339574
199positive regulation of dendritic spine morphogenesis (GO:0061003)2.63193429
200amino acid import (GO:0043090)2.63144378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27211044
2EZH2_22144423_ChIP-Seq_EOC_Human4.62567820
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.12219296
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.12219296
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.12219296
6GBX2_23144817_ChIP-Seq_PC3_Human3.99508802
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.76047521
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.37136993
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.31059525
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.30808336
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19696242
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.08840936
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04840539
14ZFP57_27257070_Chip-Seq_ESCs_Mouse3.02223137
15TAF15_26573619_Chip-Seq_HEK293_Human3.01986360
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87733108
17* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84945460
18IGF1R_20145208_ChIP-Seq_DFB_Human2.74256280
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.63448202
20* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.60799786
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.59938973
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59491219
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59417015
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57422759
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54986325
26REST_21632747_ChIP-Seq_MESCs_Mouse2.50013102
27* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.46806298
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45693287
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.44198383
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40179405
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39883365
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38612828
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35101004
34* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.33905933
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33785398
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31786889
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27652935
38ZNF274_21170338_ChIP-Seq_K562_Hela2.27136216
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25135892
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23123642
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.22560169
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.20059809
43SOX2_18555785_ChIP-Seq_MESCs_Mouse2.19433315
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.17897980
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16633341
46P300_19829295_ChIP-Seq_ESCs_Human2.12906269
47FUS_26573619_Chip-Seq_HEK293_Human2.12793156
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.12537439
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09147920
50STAT3_1855785_ChIP-Seq_MESCs_Mouse2.09119344
51RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08796443
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07958832
53CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06822565
54EST1_17652178_ChIP-ChIP_JURKAT_Human2.04019009
55REST_18959480_ChIP-ChIP_MESCs_Mouse2.03040731
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98307679
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97483816
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.97456112
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95466566
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90456319
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90316550
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.90315723
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88352290
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88305519
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.87446025
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86236035
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83112404
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82881398
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82554247
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80778961
71* CBX2_27304074_Chip-Seq_ESCs_Mouse1.80651103
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80407597
73* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.80381241
74RNF2_27304074_Chip-Seq_NSC_Mouse1.79290809
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78485055
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.76060044
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72040389
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71953250
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71750285
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69477038
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68741590
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68623653
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.68262583
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66665174
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65043271
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.63491023
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62092977
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62092977
89XRN2_22483619_ChIP-Seq_HELA_Human1.61750058
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61051777
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.60637549
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.59961632
93* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.54890779
94* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.54237072
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53065999
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51244162
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51113632
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.51032795
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50893513
100CBP_20019798_ChIP-Seq_JUKART_Human1.50893513
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50594303
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49199716
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.48872363
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.45974469
105BCAT_22108803_ChIP-Seq_LS180_Human1.45744068
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.45014977
107* STAT3_23295773_ChIP-Seq_U87_Human1.44189683
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.43545198
109DROSHA_22980978_ChIP-Seq_HELA_Human1.43336776
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43297771
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43263491
112* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42702648
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.42004375
114EWS_26573619_Chip-Seq_HEK293_Human1.39760643
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39460588
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38266073
117AR_25329375_ChIP-Seq_VCAP_Human1.38129980
118* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37298582
119* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37058495
120VDR_22108803_ChIP-Seq_LS180_Human1.36715284
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36161460
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.35993504
123AR_21909140_ChIP-Seq_LNCAP_Human1.33778706
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33713535
125AR_21572438_ChIP-Seq_LNCaP_Human1.33458717
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33400491
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31888294
128RUNX2_22187159_ChIP-Seq_PCA_Human1.30158970
129TCF4_23295773_ChIP-Seq_U87_Human1.29923850
130TTF2_22483619_ChIP-Seq_HELA_Human1.29457370
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27886436
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26815051
133EZH2_27294783_Chip-Seq_ESCs_Mouse1.25385127
134GATA1_26923725_Chip-Seq_HPCs_Mouse1.24759839
135* NANOG_16518401_ChIP-PET_MESCs_Mouse1.24743179
136VDR_23849224_ChIP-Seq_CD4+_Human1.24591939
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.24564676
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24153464
139NANOG_18555785_Chip-Seq_ESCs_Mouse1.23810398
140NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23484333
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23473618
142EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23090660
143RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23090660
144TP63_19390658_ChIP-ChIP_HaCaT_Human1.22773784
145* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22572269
146KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22557431
147TAL1_26923725_Chip-Seq_HPCs_Mouse1.21156344
148KAP1_27257070_Chip-Seq_ESCs_Mouse1.21094834
149MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21032492
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20604117
151KDM2B_26808549_Chip-Seq_REH_Human1.20227369
152AR_19668381_ChIP-Seq_PC3_Human1.19514638
153CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19490828
154* JUN_21703547_ChIP-Seq_K562_Human1.19245206
155HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16717516
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16699421
157* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16289184
158RNF2_27304074_Chip-Seq_ESCs_Mouse1.15828772
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15598697
160FOXP3_21729870_ChIP-Seq_TREG_Human1.15260714
161BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14889336
162EED_16625203_ChIP-ChIP_MESCs_Mouse1.14577672
163GABP_19822575_ChIP-Seq_HepG2_Human1.14462456
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13419473
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13203734
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13130570
167IRF1_19129219_ChIP-ChIP_H3396_Human1.11930961
168KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10582545
169P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10421967
170SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10250908
171SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09469836
172GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09446117
173ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08961668
174FLI1_21867929_ChIP-Seq_TH2_Mouse1.08607653
175SMAD4_21741376_ChIP-Seq_EPCs_Human1.07876192
176NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07627282
177DCP1A_22483619_ChIP-Seq_HELA_Human1.06607399
178P53_22387025_ChIP-Seq_ESCs_Mouse1.05968643
179TP53_16413492_ChIP-PET_HCT116_Human1.05560915
180SOX9_26525672_Chip-Seq_HEART_Mouse1.04683034
181TCF4_22108803_ChIP-Seq_LS180_Human1.04670530
182ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04308021
183RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03694866
184EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03193065
185KDM5A_27292631_Chip-Seq_BREAST_Human1.02896826
186PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91269515
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.91121218
188CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89502710
189NANOG_16153702_ChIP-ChIP_HESCs_Human0.88886240
190RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88418048
191CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87626679
192HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83468447
193TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82048180
194ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81455907
195ELK1_19687146_ChIP-ChIP_HELA_Human0.81449749
196DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81200880
197POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80776857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.83586984
2MP0004859_abnormal_synaptic_plasticity4.18588605
3MP0004957_abnormal_blastocyst_morpholog4.04659577
4MP0010094_abnormal_chromosome_stability3.69425518
5MP0000372_irregular_coat_pigmentation3.50929716
6MP0003111_abnormal_nucleus_morphology3.46012018
7MP0003693_abnormal_embryo_hatching3.39349014
8MP0004133_heterotaxia3.25429793
9MP0003635_abnormal_synaptic_transmissio3.17292239
10MP0003077_abnormal_cell_cycle3.15513980
11MP0002653_abnormal_ependyma_morphology3.11745690
12MP0004270_analgesia3.05193144
13MP0009745_abnormal_behavioral_response2.97990415
14MP0005423_abnormal_somatic_nervous2.78326396
15MP0003123_paternal_imprinting2.70799613
16MP0003283_abnormal_digestive_organ2.69655254
17MP0002735_abnormal_chemical_nociception2.68986853
18MP0002064_seizures2.68137917
19MP0002063_abnormal_learning/memory/cond2.62051118
20MP0001968_abnormal_touch/_nociception2.61442012
21MP0008058_abnormal_DNA_repair2.59807232
22MP0003890_abnormal_embryonic-extraembry2.58149043
23MP0008877_abnormal_DNA_methylation2.56764779
24MP0002272_abnormal_nervous_system2.42991161
25MP0002736_abnormal_nociception_after2.32363973
26MP0001984_abnormal_olfaction2.30936695
27MP0002102_abnormal_ear_morphology2.28374921
28MP0008932_abnormal_embryonic_tissue2.26720026
29MP0002734_abnormal_mechanical_nocicepti2.21392801
30MP0003806_abnormal_nucleotide_metabolis2.19013754
31MP0010352_gastrointestinal_tract_polyps2.16150932
32MP0000350_abnormal_cell_proliferation2.14153680
33MP0006292_abnormal_olfactory_placode2.12574302
34MP0006276_abnormal_autonomic_nervous2.11193510
35MP0001730_embryonic_growth_arrest2.10535921
36MP0000778_abnormal_nervous_system2.05270607
37MP0002822_catalepsy2.04943904
38MP0003121_genomic_imprinting2.03731093
39MP0002084_abnormal_developmental_patter1.89660268
40MP0005380_embryogenesis_phenotype1.88239475
41MP0001672_abnormal_embryogenesis/_devel1.88239475
42MP0002085_abnormal_embryonic_tissue1.81391686
43MP0002067_abnormal_sensory_capabilities1.78617174
44MP0003119_abnormal_digestive_system1.77752373
45MP0002733_abnormal_thermal_nociception1.73753991
46MP0004147_increased_porphyrin_level1.73419000
47MP0005386_behavior/neurological_phenoty1.72072298
48MP0004924_abnormal_behavior1.72072298
49MP0001970_abnormal_pain_threshold1.70530116
50MP0002557_abnormal_social/conspecific_i1.69830935
51MP0004264_abnormal_extraembryonic_tissu1.69687045
52MP0003718_maternal_effect1.69278536
53MP0003786_premature_aging1.68307985
54MP0003787_abnormal_imprinting1.66143362
55MP0001501_abnormal_sleep_pattern1.65253020
56MP0001697_abnormal_embryo_size1.64083753
57MP0003136_yellow_coat_color1.63248839
58MP0005171_absent_coat_pigmentation1.55159790
59MP0005646_abnormal_pituitary_gland1.54489471
60MP0008007_abnormal_cellular_replicative1.54115034
61MP0002086_abnormal_extraembryonic_tissu1.53937040
62MP0010030_abnormal_orbit_morphology1.53702618
63MP0005266_abnormal_metabolism1.52363281
64MP0003984_embryonic_growth_retardation1.52176956
65MP0008569_lethality_at_weaning1.49979679
66MP0002088_abnormal_embryonic_growth/wei1.49098925
67MP0002332_abnormal_exercise_endurance1.49094997
68MP0001905_abnormal_dopamine_level1.47328028
69MP0004811_abnormal_neuron_physiology1.47058461
70MP0005551_abnormal_eye_electrophysiolog1.46374521
71MP0004197_abnormal_fetal_growth/weight/1.44974531
72MP0001293_anophthalmia1.44812474
73MP0002080_prenatal_lethality1.41367621
74MP0002909_abnormal_adrenal_gland1.40494248
75MP0009780_abnormal_chondrocyte_physiolo1.40380357
76MP0005253_abnormal_eye_physiology1.39894164
77* MP0002882_abnormal_neuron_morphology1.39270170
78MP0001986_abnormal_taste_sensitivity1.39088103
79MP0000631_abnormal_neuroendocrine_gland1.37649711
80MP0010307_abnormal_tumor_latency1.34732397
81MP0005187_abnormal_penis_morphology1.33865455
82MP0002938_white_spotting1.27129913
83MP0006035_abnormal_mitochondrial_morpho1.26704347
84MP0002210_abnormal_sex_determination1.25691673
85MP0002066_abnormal_motor_capabilities/c1.25482356
86MP0001145_abnormal_male_reproductive1.24553416
87MP0002184_abnormal_innervation1.21845785
88MP0005394_taste/olfaction_phenotype1.17633338
89MP0005499_abnormal_olfactory_system1.17633338
90MP0004742_abnormal_vestibular_system1.17549193
91MP0009046_muscle_twitch1.17232170
92MP0006072_abnormal_retinal_apoptosis1.16972550
93MP0003329_amyloid_beta_deposits1.14706868
94MP0004142_abnormal_muscle_tone1.13693816
95MP0003633_abnormal_nervous_system1.12466567
96MP0002837_dystrophic_cardiac_calcinosis1.11507421
97MP0003122_maternal_imprinting1.11311860
98MP0001440_abnormal_grooming_behavior1.09995661
99MP0003941_abnormal_skin_development1.09262431
100MP0003137_abnormal_impulse_conducting1.09024292
101MP0003861_abnormal_nervous_system1.08542128
102MP0002638_abnormal_pupillary_reflex1.07432180
103MP0001929_abnormal_gametogenesis1.06290581
104MP0003011_delayed_dark_adaptation1.04682625
105MP0000313_abnormal_cell_death1.02658192
106MP0003631_nervous_system_phenotype1.02185631
107MP0001324_abnormal_eye_pigmentation1.00611008
108MP0000015_abnormal_ear_pigmentation0.97161632
109MP0000653_abnormal_sex_gland0.96837353
110MP0004233_abnormal_muscle_weight0.96698708
111MP0002229_neurodegeneration0.96590693
112MP0002234_abnormal_pharynx_morphology0.94112178
113MP0002752_abnormal_somatic_nervous0.93176649
114MP0001502_abnormal_circadian_rhythm0.92425125
115MP0001963_abnormal_hearing_physiology0.91594176
116MP0001849_ear_inflammation0.91532930
117MP0000569_abnormal_digit_pigmentation0.89996546
118MP0003698_abnormal_male_reproductive0.89550307
119MP0001188_hyperpigmentation0.88652315
120MP0000639_abnormal_adrenal_gland0.87092556
121MP0001177_atelectasis0.86976117
122MP0003315_abnormal_perineum_morphology0.86815906
123MP0001529_abnormal_vocalization0.85389566
124MP0004215_abnormal_myocardial_fiber0.83542169
125MP0005076_abnormal_cell_differentiation0.82073754
126MP0003936_abnormal_reproductive_system0.81968538
127MP0005367_renal/urinary_system_phenotyp0.79848051
128MP0000516_abnormal_urinary_system0.79848051
129MP0000358_abnormal_cell_content/0.79666459
130MP0002269_muscular_atrophy0.79205600
131MP0002111_abnormal_tail_morphology0.78402948
132MP0000013_abnormal_adipose_tissue0.78287566
133MP0000566_synostosis0.78024204
134MP0002127_abnormal_cardiovascular_syste0.76749221
135MP0001286_abnormal_eye_development0.76190917
136MP0008770_decreased_survivor_rate0.75752595
137MP0002090_abnormal_vision0.75323210
138MP0002161_abnormal_fertility/fecundity0.75187430
139MP0009703_decreased_birth_body0.74929439
140MP0003755_abnormal_palate_morphology0.74925819
141MP0003879_abnormal_hair_cell0.74496557
142MP0001346_abnormal_lacrimal_gland0.74190417
143MP0004885_abnormal_endolymph0.73146284
144MP0002019_abnormal_tumor_incidence0.72567916
145MP0000432_abnormal_head_morphology0.72521577
146MP0002160_abnormal_reproductive_system0.72139166
147MP0002751_abnormal_autonomic_nervous0.72013902
148MP0005167_abnormal_blood-brain_barrier0.71296733
149MP0003938_abnormal_ear_development0.70838812
150MP0000920_abnormal_myelination0.70579873
151MP0002069_abnormal_eating/drinking_beha0.70371358
152MP0005408_hypopigmentation0.69940180
153MP0002249_abnormal_larynx_morphology0.69876543
154MP0002114_abnormal_axial_skeleton0.69745455
155MP0000955_abnormal_spinal_cord0.69659039
156MP0008872_abnormal_physiological_respon0.69593372
157MP0000490_abnormal_crypts_of0.69442980
158MP0005384_cellular_phenotype0.69286976
159MP0004858_abnormal_nervous_system0.69168571
160MP0004145_abnormal_muscle_electrophysio0.68686913
161MP0000026_abnormal_inner_ear0.68585828
162MP0002277_abnormal_respiratory_mucosa0.68466873
163MP0000647_abnormal_sebaceous_gland0.68016913
164MP0002254_reproductive_system_inflammat0.67944828
165MP0003690_abnormal_glial_cell0.67921807
166MP0004084_abnormal_cardiac_muscle0.67382053
167MP0002152_abnormal_brain_morphology0.66804900
168MP0003632_abnormal_nervous_system0.63095194
169MP0003567_abnormal_fetal_cardiomyocyte0.61219647
170MP0005389_reproductive_system_phenotype0.60343828
171MP0003937_abnormal_limbs/digits/tail_de0.59982978
172MP0002572_abnormal_emotion/affect_behav0.59581754
173MP0003880_abnormal_central_pattern0.58698763
174MP0005075_abnormal_melanosome_morpholog0.57438604
175MP0005621_abnormal_cell_physiology0.56736076
176MP0001486_abnormal_startle_reflex0.56682005
177MP0005391_vision/eye_phenotype0.56290127

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.57860353
2Abnormality of the labia minora (HP:0012880)5.50301667
3Ependymoma (HP:0002888)5.40955670
4Atonic seizures (HP:0010819)4.90184609
5Febrile seizures (HP:0002373)4.65985849
6Focal seizures (HP:0007359)4.64571245
7Astrocytoma (HP:0009592)4.12966728
8Abnormality of the astrocytes (HP:0100707)4.12966728
9Supernumerary spleens (HP:0009799)3.98903907
10Birth length less than 3rd percentile (HP:0003561)3.87312749
11Breast hypoplasia (HP:0003187)3.85882924
12Rib fusion (HP:0000902)3.75456171
13Myokymia (HP:0002411)3.74425158
14Hyperventilation (HP:0002883)3.71241717
15Medulloblastoma (HP:0002885)3.64495272
16Ankle clonus (HP:0011448)3.64453900
17Generalized tonic-clonic seizures (HP:0002069)3.61488989
18Urinary urgency (HP:0000012)3.61173860
19Rhabdomyosarcoma (HP:0002859)3.57669175
20Limb dystonia (HP:0002451)3.55863370
21Dialeptic seizures (HP:0011146)3.54628312
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47761578
23Epileptic encephalopathy (HP:0200134)3.47616004
24Neoplasm of the oral cavity (HP:0100649)3.47118559
25Spastic gait (HP:0002064)3.44989217
26Absent radius (HP:0003974)3.44178055
27Aplasia/hypoplasia of the humerus (HP:0006507)3.43633550
28Abnormality of the lower motor neuron (HP:0002366)3.28587103
29Glioma (HP:0009733)3.28235106
30Absent forearm bone (HP:0003953)3.27308285
31Aplasia involving forearm bones (HP:0009822)3.27308285
32Absence seizures (HP:0002121)3.26942314
33Chromsome breakage (HP:0040012)3.25371808
34Short humerus (HP:0005792)3.21707919
35Rectal fistula (HP:0100590)3.17137317
36Rectovaginal fistula (HP:0000143)3.17137317
37Shawl scrotum (HP:0000049)3.11738093
38Drooling (HP:0002307)3.10234740
39Hypochromic microcytic anemia (HP:0004840)3.09422672
40Gaze-evoked nystagmus (HP:0000640)3.09372142
41Progressive cerebellar ataxia (HP:0002073)3.09307191
42Neoplasm of striated muscle (HP:0009728)3.07797592
43Abnormality of the corticospinal tract (HP:0002492)3.05879665
44Agnosia (HP:0010524)3.04187125
45Polyphagia (HP:0002591)2.97127717
46Broad-based gait (HP:0002136)2.95225996
47Mutism (HP:0002300)2.94507806
48Abnormality of abdominal situs (HP:0011620)2.90647492
49Abdominal situs inversus (HP:0003363)2.90647492
50Gait imbalance (HP:0002141)2.89117444
51Impaired vibration sensation in the lower limbs (HP:0002166)2.88935497
52Fetal akinesia sequence (HP:0001989)2.88572548
53Excessive salivation (HP:0003781)2.84687615
54Impulsivity (HP:0100710)2.79500158
55Colon cancer (HP:0003003)2.79365766
56Abnormality of the salivary glands (HP:0010286)2.79217123
57Abnormality of the ileum (HP:0001549)2.77070307
58Lower limb muscle weakness (HP:0007340)2.76626369
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.76062447
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76062447
61Selective tooth agenesis (HP:0001592)2.71354673
62Intestinal fistula (HP:0100819)2.71076268
63Patellar aplasia (HP:0006443)2.69528539
64Urinary bladder sphincter dysfunction (HP:0002839)2.68539883
65Cerebral hypomyelination (HP:0006808)2.67685831
66Meckel diverticulum (HP:0002245)2.65336570
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64891110
68Truncal ataxia (HP:0002078)2.62490780
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.62363199
70Hemiparesis (HP:0001269)2.61281270
71Bilateral microphthalmos (HP:0007633)2.60932912
72Vaginal fistula (HP:0004320)2.59162483
73Abnormal hair whorl (HP:0010721)2.55605259
74Nephroblastoma (Wilms tumor) (HP:0002667)2.52791555
75Paraplegia (HP:0010550)2.44239485
76Action tremor (HP:0002345)2.44160202
77Abnormal eating behavior (HP:0100738)2.44072907
78Epileptiform EEG discharges (HP:0011182)2.43414306
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.42672385
80Aplasia/Hypoplasia of the patella (HP:0006498)2.41960796
81Carpal bone hypoplasia (HP:0001498)2.41037515
82Tongue fasciculations (HP:0001308)2.40911043
83Absent speech (HP:0001344)2.40035715
84Esophageal atresia (HP:0002032)2.37029663
85Abnormality of the preputium (HP:0100587)2.36652621
86Lissencephaly (HP:0001339)2.36139272
87Absent thumb (HP:0009777)2.36007707
88Spastic paraplegia (HP:0001258)2.35574962
89Status epilepticus (HP:0002133)2.32757265
90Embryonal renal neoplasm (HP:0011794)2.32064587
91Congenital primary aphakia (HP:0007707)2.30669516
92Aplasia/Hypoplasia of the sternum (HP:0006714)2.30531450
93Pachygyria (HP:0001302)2.30200423
94EEG with generalized epileptiform discharges (HP:0011198)2.28556427
95Abnormal social behavior (HP:0012433)2.25780648
96Impaired social interactions (HP:0000735)2.25780648
97Premature ovarian failure (HP:0008209)2.25371105
98Hypsarrhythmia (HP:0002521)2.23859136
99Missing ribs (HP:0000921)2.23693540
100Protruding tongue (HP:0010808)2.23094700
101Nephrogenic diabetes insipidus (HP:0009806)2.22685508
102Clonus (HP:0002169)2.22184080
103Iris hypopigmentation (HP:0007730)2.22091299
104Generalized hypopigmentation (HP:0007513)2.21982119
105Abnormality of chromosome stability (HP:0003220)2.21741382
106Medial flaring of the eyebrow (HP:0010747)2.20070448
107Abnormal number of incisors (HP:0011064)2.19929515
108Inability to walk (HP:0002540)2.15770431
109Fused cervical vertebrae (HP:0002949)2.14836863
110Supranuclear gaze palsy (HP:0000605)2.14758501
111Blue irides (HP:0000635)2.13799060
112Muscle fibrillation (HP:0010546)2.12266727
113Papilledema (HP:0001085)2.12142469
114Genital tract atresia (HP:0001827)2.11331140
115Vaginal atresia (HP:0000148)2.10560483
116Delusions (HP:0000746)2.08641940
117Facial hemangioma (HP:0000329)2.08447570
118Duodenal stenosis (HP:0100867)2.07710876
119Small intestinal stenosis (HP:0012848)2.07710876
120Multiple enchondromatosis (HP:0005701)2.07478468
121Abnormality of the anterior horn cell (HP:0006802)2.05807303
122Degeneration of anterior horn cells (HP:0002398)2.05807303
123Delayed puberty (HP:0000823)2.05584335
124Poor suck (HP:0002033)2.05504151
125Limb hypertonia (HP:0002509)2.05075213
126Poor eye contact (HP:0000817)2.02015308
127Oral leukoplakia (HP:0002745)2.00553009
128Ocular albinism (HP:0001107)1.99479080
129Specific learning disability (HP:0001328)1.99318070
130Spastic tetraplegia (HP:0002510)1.98068010
131Angiofibromas (HP:0010615)1.97332956
132Adenoma sebaceum (HP:0009720)1.97332956
133Gastrointestinal atresia (HP:0002589)1.96746789
134Morphological abnormality of the pyramidal tract (HP:0002062)1.96409835
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.95908265
136Amyotrophic lateral sclerosis (HP:0007354)1.94561162
137Cortical dysplasia (HP:0002539)1.93407794
138Abnormality of cochlea (HP:0000375)1.93034891
139Asplenia (HP:0001746)1.92149672
140Sex reversal (HP:0012245)1.91955524
141Abnormal sex determination (HP:0012244)1.91955524
142Horizontal nystagmus (HP:0000666)1.91646744
143Basal cell carcinoma (HP:0002671)1.91548602
144Visual hallucinations (HP:0002367)1.90910449
145Tracheoesophageal fistula (HP:0002575)1.89161613
146Myelodysplasia (HP:0002863)1.88920766
147Upper limb muscle weakness (HP:0003484)1.88527883
148Vertebral fusion (HP:0002948)1.88445882
149Neuroblastic tumors (HP:0004376)1.87950464
150Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87950464
151Neuroblastoma (HP:0003006)1.87950464
152Primitive neuroectodermal tumor (HP:0030065)1.87950464
153Volvulus (HP:0002580)1.87894829
154Akinesia (HP:0002304)1.87582021
155Spinal muscular atrophy (HP:0007269)1.87467400
156Amblyopia (HP:0000646)1.87400617
157Renal salt wasting (HP:0000127)1.87147405
158Breast aplasia (HP:0100783)1.86981963
159Hemivertebrae (HP:0002937)1.86388872
160Cafe-au-lait spot (HP:0000957)1.86368995
161Shoulder girdle muscle weakness (HP:0003547)1.86149642
162Muscular hypotonia of the trunk (HP:0008936)1.85971469
163Hemiplegia (HP:0002301)1.85097527
164Sloping forehead (HP:0000340)1.84949422
165Split foot (HP:0001839)1.84713087
166Dysdiadochokinesis (HP:0002075)1.83785375
167Abnormal lung lobation (HP:0002101)1.83392359
168Abnormality of the duodenum (HP:0002246)1.83169594
169Sleep apnea (HP:0010535)1.83160631
170Abnormality of salivation (HP:0100755)1.82580696
171Labial hypoplasia (HP:0000066)1.82351088
172Rough bone trabeculation (HP:0100670)1.82109391
173Malignant neoplasm of the central nervous system (HP:0100836)1.81515928
174Peripheral hypomyelination (HP:0007182)1.80857385
175Decreased testicular size (HP:0008734)1.80695203
176Exotropia (HP:0000577)1.79983844
177Hypoplasia of the brainstem (HP:0002365)1.79612642
178Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79612642
179Broad alveolar ridges (HP:0000187)1.78904139
180Progressive inability to walk (HP:0002505)1.78433683
181Agitation (HP:0000713)1.78149706
182Dyskinesia (HP:0100660)1.77931725
183Stenosis of the external auditory canal (HP:0000402)1.77923480
184Abnormality of alanine metabolism (HP:0010916)1.77726201
185Hyperalaninemia (HP:0003348)1.77726201
186Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77726201
187Esotropia (HP:0000565)1.77540937
188Anophthalmia (HP:0000528)1.77193594
189Dysmetria (HP:0001310)1.76569024
190Genetic anticipation (HP:0003743)1.76524612
191Supernumerary bones of the axial skeleton (HP:0009144)1.75701575
192Aplasia/Hypoplasia of the spleen (HP:0010451)1.75571530
193Partial agenesis of the corpus callosum (HP:0001338)1.75522513
194Anxiety (HP:0000739)1.75437886
195Horseshoe kidney (HP:0000085)1.73732129
196Hypogonadotrophic hypogonadism (HP:0000044)1.72249319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.11197258
2CASK4.01783723
3WEE13.80122620
4AKT33.33804701
5BUB13.17178235
6CDC73.15141555
7TTK3.00028162
8NEK12.88304454
9PNCK2.81483057
10MAPK132.53856733
11TSSK62.53091865
12MAP4K22.50142826
13EPHA22.35148257
14BCR2.15107175
15PLK12.11554960
16MAP2K72.10769987
17CDK72.00510763
18TYRO31.97608522
19LATS21.90205677
20MAP3K91.85892249
21CHEK21.79278557
22ERBB31.75403764
23RPS6KB21.73783313
24PLK21.69436157
25TRIM281.67067643
26SRPK11.66445120
27NEK21.65460112
28INSRR1.63365811
29DAPK21.60823117
30PHKG11.57776670
31PHKG21.57776670
32EIF2AK11.57019917
33PDK31.52615614
34PDK41.52615614
35BMPR1B1.44396645
36ICK1.44347214
37PLK31.38864327
38TESK21.38130437
39CAMKK21.33422270
40FRK1.32911829
41PDK21.32496674
42GRK51.32450017
43CHEK11.32066327
44PAK31.29811754
45AURKA1.28737377
46CSNK1G21.27014304
47ATR1.23704298
48MATK1.22409521
49CDK191.22149991
50PRKCG1.22015309
51ALK1.19373835
52DYRK1A1.17962205
53OXSR11.15876642
54CAMK2A1.14794617
55CDK51.14530003
56DDR21.13870859
57CSNK1G11.10267540
58CSNK1G31.08037394
59AURKB1.05387011
60CDK21.03711507
61MAPKAPK31.02762943
62DAPK11.01766525
63ERBB41.00665045
64PAK40.99447107
65CSNK1A1L0.97485776
66MAP3K60.96171080
67DYRK20.94944421
68ATM0.93964245
69PRKCE0.92139991
70DYRK30.91526170
71CAMK2B0.91089128
72TAOK10.88253587
73MAP3K40.86162033
74BRSK20.85345442
75CSNK1E0.83431000
76PRKCI0.82910898
77EIF2AK30.81696718
78CCNB10.80747215
79TNIK0.80540487
80BRD40.79382974
81PASK0.79015796
82CAMKK10.78277211
83STK38L0.77777888
84GRK60.77425416
85CDK10.75287528
86YES10.75247181
87VRK10.75051892
88ACVR1B0.75037464
89CAMK40.72208429
90STK380.72185605
91BRSK10.71452363
92FGR0.71046134
93ARAF0.70619132
94MAP3K80.70572605
95PAK60.70408977
96CSNK2A20.70147225
97PLK40.69462246
98CDK40.68420624
99STK100.68179668
100UHMK10.66545524
101PRKCZ0.66464002
102BRAF0.65798365
103CAMK10.63579191
104PKN10.61977992
105TLK10.59088855
106SCYL20.58619676
107CDK150.57813549
108BMPR20.57666909
109STK390.57501549
110ADRBK20.57151699
111MAP2K40.57092863
112MTOR0.57085512
113PAK10.56424324
114NEK60.56233568
115CDK180.55982950
116SGK4940.55949285
117SGK2230.55949285
118MAPK100.55441249
119CSNK1D0.55326071
120CDK11A0.54893419
121MKNK10.53350064
122CDK140.50763741
123MKNK20.50576238
124CSNK2A10.49963720
125WNK30.49666852
126GRK70.49431655
127PINK10.48022764
128MAP3K110.47683193
129FER0.47624180
130CAMK2G0.47594026
131SGK20.47065216
132MARK10.46889443
133AKT20.46632231
134EPHA30.45841514
135PRKCH0.45824733
136GSK3B0.45723532
137PIK3CG0.44808671
138PRKACA0.43730246
139MAPK140.42794302
140CSNK1A10.42520789
141EPHA40.41723345
142SGK10.41698833
143NTRK30.41000081
144STK110.40853950
145MAPK70.40595848
146STK40.39899694
147NTRK10.39790403
148WNK10.39711564
149MAPK120.39706850
150PTK2B0.38776834
151CAMK1G0.38382429
152PRKDC0.38329043
153MINK10.37785736
154NTRK20.37255113
155PIM10.36680687
156PRKG10.36388091
157ADRBK10.35373858
158RPS6KA30.33359876
159PRKACB0.33002301
160CAMK2D0.32942523
161CDK30.32352057
162PRKCB0.29972780
163MAPK80.29079081
164SIK20.28936901
165MAPK90.28313586

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.74005902
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.56630074
3DNA replication_Homo sapiens_hsa030304.11462020
4RNA transport_Homo sapiens_hsa030133.44273994
5Spliceosome_Homo sapiens_hsa030402.96234024
6RNA polymerase_Homo sapiens_hsa030202.88785643
7Morphine addiction_Homo sapiens_hsa050322.83144009
8Nucleotide excision repair_Homo sapiens_hsa034202.80500403
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80385116
10One carbon pool by folate_Homo sapiens_hsa006702.78618707
11Steroid biosynthesis_Homo sapiens_hsa001002.70576442
12Homologous recombination_Homo sapiens_hsa034402.65950173
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63027221
14Base excision repair_Homo sapiens_hsa034102.50429270
15Fanconi anemia pathway_Homo sapiens_hsa034602.46110116
16Cell cycle_Homo sapiens_hsa041102.40928743
17Ribosome_Homo sapiens_hsa030102.27403464
18Proteasome_Homo sapiens_hsa030502.25385353
19Glutamatergic synapse_Homo sapiens_hsa047242.23167758
20Dopaminergic synapse_Homo sapiens_hsa047282.17243096
21mRNA surveillance pathway_Homo sapiens_hsa030152.15289103
22Circadian entrainment_Homo sapiens_hsa047132.14816160
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13663868
24Cocaine addiction_Homo sapiens_hsa050302.02372868
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92889111
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91928701
27Phototransduction_Homo sapiens_hsa047441.87467736
28Basal transcription factors_Homo sapiens_hsa030221.87426262
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87061615
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80271421
31RNA degradation_Homo sapiens_hsa030181.79443728
32Biosynthesis of amino acids_Homo sapiens_hsa012301.76298987
33Insulin secretion_Homo sapiens_hsa049111.65446279
34Pyrimidine metabolism_Homo sapiens_hsa002401.62248203
35Non-homologous end-joining_Homo sapiens_hsa034501.57071743
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52948849
37Oocyte meiosis_Homo sapiens_hsa041141.50660964
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.50583557
39Vitamin B6 metabolism_Homo sapiens_hsa007501.48511471
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42222204
41Butanoate metabolism_Homo sapiens_hsa006501.38973322
42Cholinergic synapse_Homo sapiens_hsa047251.35328611
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33357558
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32753597
45p53 signaling pathway_Homo sapiens_hsa041151.31756674
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31675046
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27027845
48Fructose and mannose metabolism_Homo sapiens_hsa000511.26178429
49Salivary secretion_Homo sapiens_hsa049701.22372491
50Olfactory transduction_Homo sapiens_hsa047401.17373741
51Gastric acid secretion_Homo sapiens_hsa049711.15292078
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12533649
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10931977
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09374411
55Serotonergic synapse_Homo sapiens_hsa047261.08516013
56Calcium signaling pathway_Homo sapiens_hsa040201.04878089
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.03220343
58Huntingtons disease_Homo sapiens_hsa050161.00065418
59Circadian rhythm_Homo sapiens_hsa047100.97880715
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96204005
61Regulation of autophagy_Homo sapiens_hsa041400.94023702
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93220380
63Axon guidance_Homo sapiens_hsa043600.93177132
64Oxytocin signaling pathway_Homo sapiens_hsa049210.93106604
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92997238
66Renin secretion_Homo sapiens_hsa049240.92724859
67cAMP signaling pathway_Homo sapiens_hsa040240.91088017
68Hippo signaling pathway_Homo sapiens_hsa043900.89449424
69Purine metabolism_Homo sapiens_hsa002300.87658611
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87211036
71Ether lipid metabolism_Homo sapiens_hsa005650.86010847
72Carbon metabolism_Homo sapiens_hsa012000.85685938
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84530174
74Ovarian steroidogenesis_Homo sapiens_hsa049130.84057654
75Synaptic vesicle cycle_Homo sapiens_hsa047210.83326279
76Nicotine addiction_Homo sapiens_hsa050330.82801400
77mTOR signaling pathway_Homo sapiens_hsa041500.80527916
78Vibrio cholerae infection_Homo sapiens_hsa051100.79103007
79Folate biosynthesis_Homo sapiens_hsa007900.77642741
80Oxidative phosphorylation_Homo sapiens_hsa001900.77374886
81beta-Alanine metabolism_Homo sapiens_hsa004100.75552971
82Hedgehog signaling pathway_Homo sapiens_hsa043400.74598444
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74338670
84Epstein-Barr virus infection_Homo sapiens_hsa051690.73221523
85Basal cell carcinoma_Homo sapiens_hsa052170.72158407
86Melanogenesis_Homo sapiens_hsa049160.71704716
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69160772
88Parkinsons disease_Homo sapiens_hsa050120.67488521
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66697989
90Protein export_Homo sapiens_hsa030600.65676523
91Dilated cardiomyopathy_Homo sapiens_hsa054140.64899646
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64649825
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63466371
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62748751
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58424856
96TGF-beta signaling pathway_Homo sapiens_hsa043500.57480444
97Viral carcinogenesis_Homo sapiens_hsa052030.57019984
98Tryptophan metabolism_Homo sapiens_hsa003800.55903331
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55526149
100Estrogen signaling pathway_Homo sapiens_hsa049150.55345243
101Galactose metabolism_Homo sapiens_hsa000520.55271318
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54236886
103Arginine and proline metabolism_Homo sapiens_hsa003300.52041132
104Tight junction_Homo sapiens_hsa045300.51376697
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.50486574
106MicroRNAs in cancer_Homo sapiens_hsa052060.50378415
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.49675660
108Colorectal cancer_Homo sapiens_hsa052100.49123239
109Thyroid cancer_Homo sapiens_hsa052160.48415608
110Wnt signaling pathway_Homo sapiens_hsa043100.48167898
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48047096
112Propanoate metabolism_Homo sapiens_hsa006400.46853262
113Pentose phosphate pathway_Homo sapiens_hsa000300.46813790
114Bile secretion_Homo sapiens_hsa049760.45727291
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45634014
116Glucagon signaling pathway_Homo sapiens_hsa049220.44981096
117Pancreatic secretion_Homo sapiens_hsa049720.44423007
118Pyruvate metabolism_Homo sapiens_hsa006200.44067947
119Fatty acid metabolism_Homo sapiens_hsa012120.44055322
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43983036
121Collecting duct acid secretion_Homo sapiens_hsa049660.43892439
122Thyroid hormone synthesis_Homo sapiens_hsa049180.43750626
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43281124
124Selenocompound metabolism_Homo sapiens_hsa004500.42530904
125Alcoholism_Homo sapiens_hsa050340.41740649
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39578704
127Fatty acid biosynthesis_Homo sapiens_hsa000610.38969254
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38675408
129GABAergic synapse_Homo sapiens_hsa047270.37927632
130Systemic lupus erythematosus_Homo sapiens_hsa053220.37867398
131Notch signaling pathway_Homo sapiens_hsa043300.37846044
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36899368
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36323312
134Histidine metabolism_Homo sapiens_hsa003400.36068325
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.35686395
136Glutathione metabolism_Homo sapiens_hsa004800.34271565
137Ras signaling pathway_Homo sapiens_hsa040140.32624134
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32451261
139Bladder cancer_Homo sapiens_hsa052190.31561898
140Sphingolipid metabolism_Homo sapiens_hsa006000.29608877
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29296206
142Cardiac muscle contraction_Homo sapiens_hsa042600.28959580
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27833620
144Glycerolipid metabolism_Homo sapiens_hsa005610.25631777
145Metabolic pathways_Homo sapiens_hsa011000.24226982
146Gap junction_Homo sapiens_hsa045400.24106742
147Long-term potentiation_Homo sapiens_hsa047200.23090023
148Sulfur relay system_Homo sapiens_hsa041220.23075971
149Melanoma_Homo sapiens_hsa052180.22777477
150Pathways in cancer_Homo sapiens_hsa052000.20452898
151Adherens junction_Homo sapiens_hsa045200.19967527
152Linoleic acid metabolism_Homo sapiens_hsa005910.19594969
153Arginine biosynthesis_Homo sapiens_hsa002200.19392105
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18196065
155HTLV-I infection_Homo sapiens_hsa051660.17843341
156Type I diabetes mellitus_Homo sapiens_hsa049400.17549059
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15866348
158Amphetamine addiction_Homo sapiens_hsa050310.15497976
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15348739
160Alzheimers disease_Homo sapiens_hsa050100.14434998
161HIF-1 signaling pathway_Homo sapiens_hsa040660.14074786
162ErbB signaling pathway_Homo sapiens_hsa040120.14022305
163Arachidonic acid metabolism_Homo sapiens_hsa005900.13518777
164Inositol phosphate metabolism_Homo sapiens_hsa005620.12713041
165Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12410490
166Taste transduction_Homo sapiens_hsa047420.11404971
167Long-term depression_Homo sapiens_hsa047300.10773603
168Drug metabolism - other enzymes_Homo sapiens_hsa009830.08413958

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