MCEE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.24031065
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.09294050
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.06054860
4ATP synthesis coupled proton transport (GO:0015986)6.06054860
5respiratory electron transport chain (GO:0022904)5.64689983
6electron transport chain (GO:0022900)5.50944524
7L-phenylalanine catabolic process (GO:0006559)5.37035533
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37035533
9L-phenylalanine metabolic process (GO:0006558)5.15396741
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.15396741
11fatty acid elongation (GO:0030497)4.72730605
12cytochrome complex assembly (GO:0017004)4.41174863
13glyoxylate metabolic process (GO:0046487)4.14595590
14aromatic amino acid family catabolic process (GO:0009074)4.13830229
15water-soluble vitamin biosynthetic process (GO:0042364)4.03299482
16protein-cofactor linkage (GO:0018065)4.03135965
17axon ensheathment in central nervous system (GO:0032291)3.96217618
18central nervous system myelination (GO:0022010)3.96217618
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.92225005
20proteasome assembly (GO:0043248)3.88028333
21maturation of 5.8S rRNA (GO:0000460)3.85510421
22cellular ketone body metabolic process (GO:0046950)3.84789951
23amino acid salvage (GO:0043102)3.82111013
24L-methionine salvage (GO:0071267)3.82111013
25L-methionine biosynthetic process (GO:0071265)3.82111013
26branched-chain amino acid catabolic process (GO:0009083)3.79344271
27aldehyde catabolic process (GO:0046185)3.73815188
28oxidative phosphorylation (GO:0006119)3.70422621
29preassembly of GPI anchor in ER membrane (GO:0016254)3.67307309
30DNA deamination (GO:0045006)3.66471708
31bile acid biosynthetic process (GO:0006699)3.65817845
32DNA double-strand break processing (GO:0000729)3.64213494
33pseudouridine synthesis (GO:0001522)3.58664934
34regulation of hexokinase activity (GO:1903299)3.57034406
35regulation of glucokinase activity (GO:0033131)3.57034406
36rRNA modification (GO:0000154)3.57017574
37platelet dense granule organization (GO:0060155)3.54799031
38* fatty acid beta-oxidation (GO:0006635)3.53884556
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52154228
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.52154228
41NADH dehydrogenase complex assembly (GO:0010257)3.52154228
42very long-chain fatty acid metabolic process (GO:0000038)3.49893920
43* fatty acid catabolic process (GO:0009062)3.46116078
44pteridine-containing compound biosynthetic process (GO:0042559)3.45227918
45peptidyl-histidine modification (GO:0018202)3.44820118
46acetyl-CoA metabolic process (GO:0006084)3.40917271
47regulation of mitochondrial translation (GO:0070129)3.39800328
48ATP biosynthetic process (GO:0006754)3.38787768
49aspartate family amino acid catabolic process (GO:0009068)3.38173700
50protein complex biogenesis (GO:0070271)3.37140456
51* short-chain fatty acid metabolic process (GO:0046459)3.36842727
52signal peptide processing (GO:0006465)3.36258348
53ketone body metabolic process (GO:1902224)3.32455995
54xenobiotic catabolic process (GO:0042178)3.32011828
55coenzyme catabolic process (GO:0009109)3.31027959
56GPI anchor metabolic process (GO:0006505)3.28997333
57cullin deneddylation (GO:0010388)3.27499899
58* fatty acid oxidation (GO:0019395)3.27240441
59GPI anchor biosynthetic process (GO:0006506)3.26654840
60cholesterol biosynthetic process (GO:0006695)3.26206342
61chaperone-mediated protein transport (GO:0072321)3.25633171
62C-terminal protein lipidation (GO:0006501)3.25548961
63S-adenosylmethionine metabolic process (GO:0046500)3.25469063
64* lipid oxidation (GO:0034440)3.25306396
65* acyl-CoA metabolic process (GO:0006637)3.24929111
66* thioester metabolic process (GO:0035383)3.24929111
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.24465427
68branched-chain amino acid metabolic process (GO:0009081)3.23151260
69cysteine metabolic process (GO:0006534)3.23147248
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20049864
71cofactor catabolic process (GO:0051187)3.20024133
72* monocarboxylic acid catabolic process (GO:0072329)3.19736133
73mannosylation (GO:0097502)3.19270528
74purine nucleoside triphosphate biosynthetic process (GO:0009145)3.18028538
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17110722
76protein neddylation (GO:0045116)3.16326346
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15951207
78sulfur amino acid catabolic process (GO:0000098)3.14434256
79methionine biosynthetic process (GO:0009086)3.14393250
80thioester biosynthetic process (GO:0035384)3.12151529
81acyl-CoA biosynthetic process (GO:0071616)3.12151529
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11056258
83inner mitochondrial membrane organization (GO:0007007)3.09798998
84lysine catabolic process (GO:0006554)3.09596034
85lysine metabolic process (GO:0006553)3.09596034
86protein deneddylation (GO:0000338)3.08736744
87regulation of triglyceride catabolic process (GO:0010896)3.08123778
88indole-containing compound catabolic process (GO:0042436)3.07880085
89indolalkylamine catabolic process (GO:0046218)3.07880085
90tryptophan catabolic process (GO:0006569)3.07880085
91DNA catabolic process, exonucleolytic (GO:0000738)3.07393773
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06818187
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06818187
94aromatic amino acid family metabolic process (GO:0009072)3.05703155
95ethanol oxidation (GO:0006069)3.05079047
96alpha-linolenic acid metabolic process (GO:0036109)3.04722178
97response to pheromone (GO:0019236)3.04065005
98mitochondrial respiratory chain complex assembly (GO:0033108)3.03844020
99heme transport (GO:0015886)3.03755921
100hydrogen ion transmembrane transport (GO:1902600)3.03220431
101ubiquinone biosynthetic process (GO:0006744)3.02524706
102quinone biosynthetic process (GO:1901663)3.02524706
103creatine metabolic process (GO:0006600)2.99228367
104rRNA methylation (GO:0031167)2.97827422
105positive regulation of cellular amine metabolic process (GO:0033240)2.96120547
106tryptophan metabolic process (GO:0006568)2.95864614
107regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.95482144
108* fatty-acyl-CoA metabolic process (GO:0035337)2.94367075
109C-terminal protein amino acid modification (GO:0018410)2.93945220
110fatty-acyl-CoA biosynthetic process (GO:0046949)2.93312916
111kynurenine metabolic process (GO:0070189)2.91786275
112* organic acid catabolic process (GO:0016054)2.90340912
113* carboxylic acid catabolic process (GO:0046395)2.90340912
114aerobic respiration (GO:0009060)2.90238645
115glutathione metabolic process (GO:0006749)2.89032225
116glutathione derivative metabolic process (GO:1901685)2.88315705
117glutathione derivative biosynthetic process (GO:1901687)2.88315705
118alpha-amino acid catabolic process (GO:1901606)2.87780259
119bile acid metabolic process (GO:0008206)2.87476542
120sterol biosynthetic process (GO:0016126)2.87341574
121inositol phosphate catabolic process (GO:0071545)2.87293889
122amino-acid betaine metabolic process (GO:0006577)2.85732032
123adenosine metabolic process (GO:0046085)2.85123964
124termination of RNA polymerase III transcription (GO:0006386)2.84981371
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.84981371
126cellular amino acid catabolic process (GO:0009063)2.83477291
127regulation of cholesterol metabolic process (GO:0090181)2.83247603
128ubiquinone metabolic process (GO:0006743)2.83235054
129regulation of cilium movement (GO:0003352)2.82263221
130proton transport (GO:0015992)2.80314621
131tyrosine metabolic process (GO:0006570)2.78567288
132hydrogen transport (GO:0006818)2.78016075
133tricarboxylic acid cycle (GO:0006099)2.77929123
134long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77397179
135low-density lipoprotein particle remodeling (GO:0034374)2.77163345
136regulation of cholesterol esterification (GO:0010872)2.77066245
137regulation of cellular amino acid metabolic process (GO:0006521)2.76972527
138aspartate family amino acid biosynthetic process (GO:0009067)2.76441030
139quinone metabolic process (GO:1901661)2.71667625
140dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.71537329
141positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70195365
142ethanol metabolic process (GO:0006067)2.70118500
143DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69274126
144ribosome assembly (GO:0042255)2.69013916
145ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67885695
146glutathione biosynthetic process (GO:0006750)2.67312653
147cellular respiration (GO:0045333)2.66619624
148methionine metabolic process (GO:0006555)2.66462517
149long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.64536911
150detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64505735
151nucleotide transmembrane transport (GO:1901679)2.64448597
152carnitine metabolic process (GO:0009437)2.64289866
153respiratory chain complex IV assembly (GO:0008535)2.62358408
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61920944
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61920944
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61920944
157establishment of protein localization to mitochondrial membrane (GO:0090151)2.60467658
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58697048
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58697048
160synapsis (GO:0007129)2.58373932
161valine metabolic process (GO:0006573)2.57640618
162lactate metabolic process (GO:0006089)2.57124468
163protein targeting to mitochondrion (GO:0006626)2.56182972
164polyol catabolic process (GO:0046174)2.56070671
165regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.55465332
166tRNA processing (GO:0008033)2.54819949
167regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.54343111
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52823473
169inositol phosphate dephosphorylation (GO:0046855)2.51646310
170phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51646310
171positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51522407
172histone H2A acetylation (GO:0043968)2.50187655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.58898547
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94914776
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.34028109
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.10120271
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.03453926
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49500322
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.41260760
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40921507
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.21116685
10ZNF274_21170338_ChIP-Seq_K562_Hela3.08189013
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06608630
12ELK1_19687146_ChIP-ChIP_HELA_Human2.70346500
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.62186558
14VDR_23849224_ChIP-Seq_CD4+_Human2.50969715
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50544985
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39956786
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37740082
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15158667
19* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.13937002
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.07380821
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03191050
22* FOXP3_21729870_ChIP-Seq_TREG_Human2.01450184
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98687712
24IGF1R_20145208_ChIP-Seq_DFB_Human1.98400729
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.98324566
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.93667599
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.93145226
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91027949
29EWS_26573619_Chip-Seq_HEK293_Human1.89737724
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88552836
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86814389
32* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81309228
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74737182
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.74644400
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74520763
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69180370
37HTT_18923047_ChIP-ChIP_STHdh_Human1.68012306
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66706584
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60302316
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58193370
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56998262
42* MYC_18940864_ChIP-ChIP_HL60_Human1.53823407
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53088083
44TP53_22573176_ChIP-Seq_HFKS_Human1.53063509
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.52104598
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48844444
47VDR_22108803_ChIP-Seq_LS180_Human1.48076525
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46678543
49GABP_19822575_ChIP-Seq_HepG2_Human1.42750077
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40872464
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36650418
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35671058
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34442723
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.30471928
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30471928
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29765283
57CBP_20019798_ChIP-Seq_JUKART_Human1.29765283
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.29172246
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29013408
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.28242455
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25099561
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25099561
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25046728
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.21049254
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19958341
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.18691344
67TAF15_26573619_Chip-Seq_HEK293_Human1.16413852
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16383211
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12529816
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11398539
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11135122
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10604589
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09562398
74GATA1_22025678_ChIP-Seq_K562_Human1.09242573
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05950057
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05398982
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.04632107
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04162193
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.02785887
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02582065
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01413629
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99278891
83* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99000725
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.98821463
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98609492
86IRF1_19129219_ChIP-ChIP_H3396_Human0.97772802
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97405841
88BCAT_22108803_ChIP-Seq_LS180_Human0.97383206
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96742512
90CDX2_22108803_ChIP-Seq_LS180_Human0.96268944
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.94303384
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93895045
93AR_20517297_ChIP-Seq_VCAP_Human0.93384309
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92859249
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.92237009
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91394739
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90440321
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90359188
99TTF2_22483619_ChIP-Seq_HELA_Human0.90323190
100TCF4_22108803_ChIP-Seq_LS180_Human0.90101991
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89592977
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89018652
103ER_23166858_ChIP-Seq_MCF-7_Human0.88856224
104SMAD4_21799915_ChIP-Seq_A2780_Human0.88769058
105ERG_20517297_ChIP-Seq_VCAP_Human0.88506900
106PHF8_20622853_ChIP-Seq_HELA_Human0.88505452
107E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88146452
108GATA3_21878914_ChIP-Seq_MCF-7_Human0.88089863
109P53_22387025_ChIP-Seq_ESCs_Mouse0.88055369
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87464839
111MYC_18555785_ChIP-Seq_MESCs_Mouse0.86986450
112AR_25329375_ChIP-Seq_VCAP_Human0.86968412
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.86448801
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85891033
115* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84371747
116* NANOG_20526341_ChIP-Seq_ESCs_Human0.83759804
117SOX2_19829295_ChIP-Seq_ESCs_Human0.83612206
118NANOG_19829295_ChIP-Seq_ESCs_Human0.83612206
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82094508
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80682624
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79521180
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79265430
123STAT1_20625510_ChIP-Seq_HELA_Human0.79083721
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78724867
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77041873
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.76830209
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75914930
128SOX2_20726797_ChIP-Seq_SW620_Human0.74371038
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73448792
130NCOR_22424771_ChIP-Seq_293T_Human0.73317504
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72232142
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71177772
133EOMES_21245162_ChIP-Seq_HESCs_Human0.70951149
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68728673
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.68043757
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67399211
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.67183968
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.67114109
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65866179
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65750067
141OCT4_20526341_ChIP-Seq_ESCs_Human0.64986999
142TAF2_19829295_ChIP-Seq_ESCs_Human0.64906624
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.64891238
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64335231
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.64328464
146GBX2_23144817_ChIP-Seq_PC3_Human0.64161410
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.64110344
148SALL4_22934838_ChIP-ChIP_CD34+_Human0.63726099
149SOX2_22085726_ChIP-Seq_NPCs_Mouse0.63084698
150ELF1_17652178_ChIP-ChIP_JURKAT_Human0.62498501
151FUS_26573619_Chip-Seq_HEK293_Human0.61571250
152P300_19829295_ChIP-Seq_ESCs_Human0.60999688
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59542328
154SMC3_22415368_ChIP-Seq_MEFs_Mouse0.59097550
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58314698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.36997141
2MP0003806_abnormal_nucleotide_metabolis4.34195885
3MP0005360_urolithiasis4.20654455
4MP0005085_abnormal_gallbladder_physiolo3.99996305
5MP0005365_abnormal_bile_salt3.76665551
6MP0008875_abnormal_xenobiotic_pharmacok3.57589915
7MP0003195_calcinosis3.38621989
8MP0002837_dystrophic_cardiac_calcinosis2.93780578
9MP0005332_abnormal_amino_acid2.58713679
10MP0006036_abnormal_mitochondrial_physio2.52018523
11MP0008058_abnormal_DNA_repair2.49947386
12MP0005451_abnormal_body_composition2.38275241
13MP0003646_muscle_fatigue2.35827452
14MP0003186_abnormal_redox_activity2.31858596
15MP0002163_abnormal_gland_morphology2.30101296
16MP0008877_abnormal_DNA_methylation2.29422351
17MP0005645_abnormal_hypothalamus_physiol2.21232984
18MP0004043_abnormal_pH_regulation2.14691004
19MP0005083_abnormal_biliary_tract2.12622792
20MP0009379_abnormal_foot_pigmentation2.08884162
21MP0003786_premature_aging2.03797273
22MP0001529_abnormal_vocalization2.00676209
23MP0005220_abnormal_exocrine_pancreas2.00185623
24MP0006072_abnormal_retinal_apoptosis1.98708513
25MP0010329_abnormal_lipoprotein_level1.88960602
26MP0009840_abnormal_foam_cell1.86949571
27MP0000013_abnormal_adipose_tissue1.86032488
28MP0001666_abnormal_nutrient_absorption1.84550224
29MP0005551_abnormal_eye_electrophysiolog1.84170675
30MP0009697_abnormal_copulation1.82391910
31MP0004036_abnormal_muscle_relaxation1.79915171
32MP0000920_abnormal_myelination1.79859172
33MP0001984_abnormal_olfaction1.79326279
34MP0002102_abnormal_ear_morphology1.79259612
35MP0000749_muscle_degeneration1.76241867
36MP0004147_increased_porphyrin_level1.70509439
37MP0002118_abnormal_lipid_homeostasis1.68317830
38MP0008995_early_reproductive_senescence1.67942274
39MP0005646_abnormal_pituitary_gland1.66425317
40MP0005584_abnormal_enzyme/coenzyme_acti1.65887262
41MP0009780_abnormal_chondrocyte_physiolo1.65020172
42MP0001764_abnormal_homeostasis1.60327033
43MP0005253_abnormal_eye_physiology1.56861821
44MP0001905_abnormal_dopamine_level1.52030257
45MP0004215_abnormal_myocardial_fiber1.51570806
46MP0005330_cardiomyopathy1.49883310
47MP0005367_renal/urinary_system_phenotyp1.49400628
48MP0000516_abnormal_urinary_system1.49400628
49MP0003950_abnormal_plasma_membrane1.48005127
50MP0006035_abnormal_mitochondrial_morpho1.47239069
51MP0002132_abnormal_respiratory_system1.44048240
52MP0003283_abnormal_digestive_organ1.43442491
53MP0003252_abnormal_bile_duct1.42503285
54MP0005670_abnormal_white_adipose1.42018492
55MP0009643_abnormal_urine_homeostasis1.41750904
56MP0003011_delayed_dark_adaptation1.40836036
57MP0003690_abnormal_glial_cell1.39244407
58MP0004084_abnormal_cardiac_muscle1.38676165
59MP0001944_abnormal_pancreas_morphology1.37144604
60MP0005636_abnormal_mineral_homeostasis1.36788701
61MP0003656_abnormal_erythrocyte_physiolo1.36598871
62MP0005319_abnormal_enzyme/_coenzyme1.35658822
63MP0006054_spinal_hemorrhage1.34097786
64MP0004019_abnormal_vitamin_homeostasis1.33521438
65MP0002938_white_spotting1.31606624
66MP0005084_abnormal_gallbladder_morpholo1.31125233
67MP0004142_abnormal_muscle_tone1.30266729
68MP0005410_abnormal_fertilization1.27687896
69MP0000751_myopathy1.25183440
70MP0005408_hypopigmentation1.24413021
71MP0010386_abnormal_urinary_bladder1.24269955
72MP0005535_abnormal_body_temperature1.22402247
73MP0003191_abnormal_cellular_cholesterol1.22030722
74MP0002693_abnormal_pancreas_physiology1.20650653
75MP0002254_reproductive_system_inflammat1.17889464
76MP0002090_abnormal_vision1.17588837
77MP0002972_abnormal_cardiac_muscle1.15206157
78MP0010094_abnormal_chromosome_stability1.14067509
79MP0003136_yellow_coat_color1.13068461
80MP0005165_increased_susceptibility_to1.12751186
81MP0002277_abnormal_respiratory_mucosa1.10279083
82MP0003329_amyloid_beta_deposits1.10125029
83MP0005266_abnormal_metabolism1.08449231
84MP0004381_abnormal_hair_follicle1.05888756
85MP0000609_abnormal_liver_physiology1.04293300
86MP0000230_abnormal_systemic_arterial1.04199294
87MP0008789_abnormal_olfactory_epithelium1.03993334
88MP0003724_increased_susceptibility_to1.03973373
89MP0005376_homeostasis/metabolism_phenot1.01369540
90MP0004130_abnormal_muscle_cell1.00359253
91MP0002822_catalepsy0.98281019
92MP0002928_abnormal_bile_duct0.95914150
93MP0004145_abnormal_muscle_electrophysio0.94146454
94MP0002876_abnormal_thyroid_physiology0.93528635
95MP0005620_abnormal_muscle_contractility0.92995537
96MP0002138_abnormal_hepatobiliary_system0.91544927
97MP0002160_abnormal_reproductive_system0.91369919
98MP0008007_abnormal_cellular_replicative0.91109873
99MP0001929_abnormal_gametogenesis0.89287373
100MP0000604_amyloidosis0.87925196
101MP0005379_endocrine/exocrine_gland_phen0.86746377
102MP0003868_abnormal_feces_composition0.86310672
103MP0003137_abnormal_impulse_conducting0.84703499
104MP0004134_abnormal_chest_morphology0.84276404
105MP0000358_abnormal_cell_content/0.83806004
106MP0000372_irregular_coat_pigmentation0.83475640
107MP0001661_extended_life_span0.82977861
108MP0005174_abnormal_tail_pigmentation0.82354026
109MP0004484_altered_response_of0.82059671
110MP0000747_muscle_weakness0.81856374
111MP0001544_abnormal_cardiovascular_syste0.80302861
112MP0005385_cardiovascular_system_phenoty0.80302861
113MP0000653_abnormal_sex_gland0.80160849
114MP0002332_abnormal_exercise_endurance0.79752191
115MP0004085_abnormal_heartbeat0.79160073
116MP0000015_abnormal_ear_pigmentation0.79109067
117MP0000631_abnormal_neuroendocrine_gland0.78685935
118MP0002295_abnormal_pulmonary_circulatio0.78304120
119MP0005058_abnormal_lysosome_morphology0.76689993
120MP0000427_abnormal_hair_cycle0.75865116
121MP0009046_muscle_twitch0.75261880
122MP0001145_abnormal_male_reproductive0.74657638
123MP0004133_heterotaxia0.74592633
124MP0001756_abnormal_urination0.74414700
125MP0000639_abnormal_adrenal_gland0.74290524
126MP0002210_abnormal_sex_determination0.74244513
127MP0008775_abnormal_heart_ventricle0.74111186
128MP0002095_abnormal_skin_pigmentation0.73662123
129MP0001485_abnormal_pinna_reflex0.73203344
130MP0006138_congestive_heart_failure0.72023650
131MP0005647_abnormal_sex_gland0.71143179
132MP0002971_abnormal_brown_adipose0.71022702
133MP0005389_reproductive_system_phenotype0.70962711
134MP0000343_altered_response_to0.70864245
135MP0005075_abnormal_melanosome_morpholog0.70733402
136MP0003718_maternal_effect0.70239709
137MP0008469_abnormal_protein_level0.69927514
138MP0001765_abnormal_ion_homeostasis0.68747145
139MP0003880_abnormal_central_pattern0.68398089
140MP0001440_abnormal_grooming_behavior0.68341150
141MP0005409_darkened_coat_color0.68207654
142MP0002106_abnormal_muscle_physiology0.68043204
143MP0002078_abnormal_glucose_homeostasis0.67422224
144MP0002909_abnormal_adrenal_gland0.67301820
145MP0003698_abnormal_male_reproductive0.66791964
146MP0005666_abnormal_adipose_tissue0.66513355
147MP0009763_increased_sensitivity_to0.65947575
148MP0005395_other_phenotype0.65880332
149MP0002638_abnormal_pupillary_reflex0.65872340
150MP0004885_abnormal_endolymph0.65699787
151MP0009642_abnormal_blood_homeostasis0.65194603
152MP0008872_abnormal_physiological_respon0.62658970
153MP0002229_neurodegeneration0.61454375
154MP0004782_abnormal_surfactant_physiolog0.60801394

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.33042468
2Acute encephalopathy (HP:0006846)5.12318748
3Abnormal mitochondria in muscle tissue (HP:0008316)4.96941301
4Mitochondrial inheritance (HP:0001427)4.68585803
5Hepatic necrosis (HP:0002605)4.67040031
6Cerebral edema (HP:0002181)4.47566875
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.44139328
8Hepatocellular necrosis (HP:0001404)4.39301821
9Progressive macrocephaly (HP:0004481)4.38217083
10Increased CSF lactate (HP:0002490)4.15859413
11Lipid accumulation in hepatocytes (HP:0006561)4.10578655
12Increased hepatocellular lipid droplets (HP:0006565)3.94320806
13Renal Fanconi syndrome (HP:0001994)3.89388275
14Intrahepatic cholestasis (HP:0001406)3.68891685
15Hypoglycemic coma (HP:0001325)3.61186645
16Abnormality of glycolysis (HP:0004366)3.54154705
17Increased serum pyruvate (HP:0003542)3.54154705
18Increased intramyocellular lipid droplets (HP:0012240)3.52860610
19Increased muscle lipid content (HP:0009058)3.52164351
20Abnormality of fatty-acid metabolism (HP:0004359)3.46446669
21Lactic acidosis (HP:0003128)3.33949180
22Ketosis (HP:0001946)3.31631375
23Generalized aminoaciduria (HP:0002909)3.26163304
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25433658
25* Dicarboxylic aciduria (HP:0003215)3.24095488
26* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.24095488
27Lethargy (HP:0001254)3.13845558
28Prolonged partial thromboplastin time (HP:0003645)3.12004205
29Glycosuria (HP:0003076)3.10724570
30Abnormality of urine glucose concentration (HP:0011016)3.10724570
31Respiratory failure (HP:0002878)3.05759343
32Abnormality of the renal cortex (HP:0011035)3.04811047
33Ketoacidosis (HP:0001993)3.04311550
34Abnormality of glycine metabolism (HP:0010895)3.03437988
35Abnormality of serine family amino acid metabolism (HP:0010894)3.03437988
36Leukodystrophy (HP:0002415)3.01613913
37Hyperammonemia (HP:0001987)2.97306916
38Exercise intolerance (HP:0003546)2.92208688
39Abnormality of alanine metabolism (HP:0010916)2.90824268
40Hyperalaninemia (HP:0003348)2.90824268
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90824268
42Medial flaring of the eyebrow (HP:0010747)2.90505980
43Hyperlipoproteinemia (HP:0010980)2.88656395
44Xanthomatosis (HP:0000991)2.87997347
45Hyperglycinuria (HP:0003108)2.83856178
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83203553
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79352489
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79352489
493-Methylglutaconic aciduria (HP:0003535)2.78675305
50Increased serum lactate (HP:0002151)2.78089116
51Pancreatic cysts (HP:0001737)2.74022467
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73601587
53Hyperglycinemia (HP:0002154)2.72951394
54Optic disc pallor (HP:0000543)2.70181609
55Hypobetalipoproteinemia (HP:0003563)2.65173689
56Muscle hypertrophy of the lower extremities (HP:0008968)2.62935749
57Hypothermia (HP:0002045)2.59788246
58Vomiting (HP:0002013)2.59668923
59Abnormality of renal resorption (HP:0011038)2.58523028
60Calf muscle hypertrophy (HP:0008981)2.54694009
61Parakeratosis (HP:0001036)2.51178215
62Abnormal protein glycosylation (HP:0012346)2.49309204
63Abnormal glycosylation (HP:0012345)2.49309204
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49309204
65Abnormal protein N-linked glycosylation (HP:0012347)2.49309204
66Type I transferrin isoform profile (HP:0003642)2.47743313
67Exertional dyspnea (HP:0002875)2.46621833
68Deep venous thrombosis (HP:0002625)2.45568007
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43995807
70Pancreatic fibrosis (HP:0100732)2.42566109
71* Metabolic acidosis (HP:0001942)2.41804661
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35277254
73Proximal tubulopathy (HP:0000114)2.35136045
74True hermaphroditism (HP:0010459)2.34116335
75Fat malabsorption (HP:0002630)2.33363116
76Abnormality of methionine metabolism (HP:0010901)2.33017482
77Cerebral hemorrhage (HP:0001342)2.32113236
78CNS demyelination (HP:0007305)2.28579831
79Nephronophthisis (HP:0000090)2.28235890
80Molar tooth sign on MRI (HP:0002419)2.27482024
81Abnormality of midbrain morphology (HP:0002418)2.27482024
82Neuroendocrine neoplasm (HP:0100634)2.27389618
83Myoglobinuria (HP:0002913)2.25339335
84Hyperphosphaturia (HP:0003109)2.24586820
85* Abnormality of vitamin B metabolism (HP:0004340)2.24328461
86Congenital primary aphakia (HP:0007707)2.22762299
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21246176
88Delayed CNS myelination (HP:0002188)2.20606296
89Pheochromocytoma (HP:0002666)2.20153675
90* Methylmalonic aciduria (HP:0012120)2.19987323
91Steatorrhea (HP:0002570)2.19431600
92Nephrogenic diabetes insipidus (HP:0009806)2.17297966
93Thyroiditis (HP:0100646)2.16063491
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13145197
95Degeneration of the lateral corticospinal tracts (HP:0002314)2.13145197
96Abnormality of serum amino acid levels (HP:0003112)2.12048515
97Respiratory difficulties (HP:0002880)2.09616458
98Spastic paraparesis (HP:0002313)2.08940140
99Gait imbalance (HP:0002141)2.07968602
100Abnormality of the renal medulla (HP:0100957)2.06904078
101Nausea (HP:0002018)2.01989452
102Pancreatic islet-cell hyperplasia (HP:0004510)2.01631251
103Hypoglycemic seizures (HP:0002173)2.01187567
104* Methylmalonic acidemia (HP:0002912)2.00796818
105Palpitations (HP:0001962)1.98992452
106Congenital ichthyosiform erythroderma (HP:0007431)1.96332087
107Neoplasm of the adrenal gland (HP:0100631)1.96233923
108Microvesicular hepatic steatosis (HP:0001414)1.96091076
109X-linked dominant inheritance (HP:0001423)1.95946710
110Hypoplasia of the fovea (HP:0007750)1.95659241
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.95659241
112Abnormal urine phosphate concentration (HP:0012599)1.95086227
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94496455
114Hyperbilirubinemia (HP:0002904)1.94314644
115Severe combined immunodeficiency (HP:0004430)1.93807041
116Neurofibrillary tangles (HP:0002185)1.90496668
117Hypolipoproteinemia (HP:0010981)1.88445135
118Hyperglycemia (HP:0003074)1.86329146
119Abnormality of endocrine pancreas physiology (HP:0012093)1.85676833
120Abnormality of the pancreatic islet cells (HP:0006476)1.85676833
121Hypoproteinemia (HP:0003075)1.84857467
122Hyperinsulinemic hypoglycemia (HP:0000825)1.84616626
123Degeneration of anterior horn cells (HP:0002398)1.84526394
124Abnormality of the anterior horn cell (HP:0006802)1.84526394
125Abnormality of cells of the erythroid lineage (HP:0012130)1.83908626
126Cholecystitis (HP:0001082)1.82078417
127Abnormal gallbladder physiology (HP:0012438)1.82078417
128Renal cortical cysts (HP:0000803)1.79563728
129Large for gestational age (HP:0001520)1.78187860
130Conjugated hyperbilirubinemia (HP:0002908)1.77876319
131Rhabdomyolysis (HP:0003201)1.77056861
132Metaphyseal dysplasia (HP:0100255)1.76429647
133Respiratory distress (HP:0002098)1.76363525
134Renal tubular dysfunction (HP:0000124)1.75566669
135Brushfield spots (HP:0001088)1.75448573
136Albinism (HP:0001022)1.74587497
137* Abnormality of the vitamin B12 metabolism (HP:0004341)1.74490936
138Abnormality of the common coagulation pathway (HP:0010990)1.74356776
139Complement deficiency (HP:0004431)1.73981194
140Bile duct proliferation (HP:0001408)1.73449672
141Abnormal biliary tract physiology (HP:0012439)1.73449672
142Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73387511
143Poor head control (HP:0002421)1.69634862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.60162237
2STK394.09656640
3FRK3.72758904
4OXSR13.16820888
5NUAK12.80481483
6WNK42.77975674
7NME22.77871764
8MYLK2.72771100
9EIF2AK12.68973753
10STK162.68636804
11MUSK2.58706390
12MST42.58500052
13NEK12.37197728
14ARAF2.28953597
15MAP4K22.27359213
16OBSCN2.17365108
17PBK2.15291164
18MAPKAPK52.09910554
19ZAK2.09376956
20INSRR2.00997702
21VRK21.98658132
22GRK71.83980118
23MAP3K41.71525458
24PKN11.70196503
25PIM21.66196958
26PIK3CG1.61983848
27PLK21.59163025
28BCR1.58149179
29SRPK11.52706648
30CDK191.44671730
31MAPK151.44232430
32AKT31.40044089
33TNIK1.35302296
34TIE11.33075987
35PHKG11.30640769
36PHKG21.30640769
37CAMK2D1.29351719
38PDK21.23157431
39NME11.20552173
40PLK31.19973286
41EPHB11.19223835
42TRIM281.19055550
43TLK11.18916532
44ERBB31.18395357
45PIK3CA1.15680954
46CASK1.15115174
47PLK41.14875335
48PINK11.11183937
49BUB11.10880443
50PASK1.08892935
51MAP3K31.05886627
52ABL21.05742529
53CAMK2G1.05330161
54TNK21.04236858
55GRK11.03991474
56BMPR1B1.02211645
57ADRBK20.99776192
58IRAK30.99561396
59CSNK1G30.99349891
60TXK0.97716223
61TSSK60.94870872
62MAPKAPK30.93957882
63LMTK20.93728630
64MAP3K120.93641428
65BRSK20.91837426
66EIF2AK20.91624794
67STK38L0.90796494
68BMPR20.90302269
69CAMK2B0.90297770
70ACVR1B0.89515001
71LIMK10.88967165
72KDR0.88795418
73MAPK120.88782688
74MAPK130.88514567
75WNK30.88297225
76PDK40.86846394
77PDK30.86846394
78FGFR20.85953644
79CAMK2A0.82121942
80NEK60.81436616
81VRK10.81327074
82TTK0.81094899
83MAP2K60.78569529
84PRKCE0.76395882
85TBK10.74815640
86MKNK20.74813727
87PRKCQ0.72738423
88FLT30.71735780
89CDK80.70560128
90RPS6KA40.69995214
91DAPK30.69814123
92MAPK40.69154737
93BRAF0.67578892
94CSNK1G10.67004825
95STK240.65859642
96TEC0.65270675
97STK30.64373303
98ILK0.63595613
99TRPM70.60073526
100TGFBR10.59174073
101FER0.58896712
102MET0.58800682
103WEE10.58325892
104ROCK20.57508231
105PRKACA0.57286879
106MAP2K70.56844465
107IRAK40.56760817
108TESK20.56688721
109CSNK1G20.56279306
110ADRBK10.55282165
111TTN0.54999904
112PRKD10.54301083
113CLK10.51760267
114PRKCG0.51112125
115MST1R0.50482770
116ERBB40.50413754
117PDPK10.49674731
118CSNK2A20.49628158
119EPHA30.49628126
120IKBKE0.49051219
121RPS6KA50.48519985
122EIF2AK30.48375815
123ATM0.48324408
124MKNK10.48262640
125PLK10.48187561
126PRKCI0.47222164
127ATR0.47166809
128MAP2K30.46820778
129PAK30.46663727
130PRKACB0.44394549
131DYRK20.43459972
132KIT0.42835723
133IKBKB0.42733114
134CSNK2A10.42259797
135GRK50.41882475
136PRKAA20.41811352
137WNK10.41089511
138DAPK10.40779857
139PRKG10.40770886
140UHMK10.40346587
141PRKG20.39465084
142MAP2K20.39433374
143DAPK20.38922865
144PTK2B0.37053616
145STK40.35818178
146CAMK10.35700666
147PNCK0.35632470
148SGK2230.35576675
149SGK4940.35576675
150CSNK1A10.35166634
151PRKCA0.35032485
152TAOK30.33931940
153PRPF4B0.33618853
154CSNK1A1L0.32982405

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.83780461
2Parkinsons disease_Homo sapiens_hsa050123.19270969
3Fatty acid elongation_Homo sapiens_hsa000622.97803959
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61373169
5* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58737705
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.56924941
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51414342
8* Propanoate metabolism_Homo sapiens_hsa006402.49555031
9Alzheimers disease_Homo sapiens_hsa050102.42027923
10Sulfur metabolism_Homo sapiens_hsa009202.31418086
11Fatty acid degradation_Homo sapiens_hsa000712.29909484
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22041921
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10175354
14Peroxisome_Homo sapiens_hsa041462.06438216
15Huntingtons disease_Homo sapiens_hsa050162.04572407
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03114956
17Protein export_Homo sapiens_hsa030602.00876151
18Butanoate metabolism_Homo sapiens_hsa006501.99381220
19Steroid biosynthesis_Homo sapiens_hsa001001.99111521
20* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97797629
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91749723
22Fatty acid metabolism_Homo sapiens_hsa012121.89902458
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86910146
24Histidine metabolism_Homo sapiens_hsa003401.85812992
25One carbon pool by folate_Homo sapiens_hsa006701.85366492
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79648335
27Homologous recombination_Homo sapiens_hsa034401.79545210
28Tryptophan metabolism_Homo sapiens_hsa003801.75788930
29Pyruvate metabolism_Homo sapiens_hsa006201.70405491
30Non-homologous end-joining_Homo sapiens_hsa034501.63224485
31Ribosome_Homo sapiens_hsa030101.63085003
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61645634
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58008086
34Cardiac muscle contraction_Homo sapiens_hsa042601.57649718
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55820383
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51164272
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48579126
38Chemical carcinogenesis_Homo sapiens_hsa052041.45304701
39Mismatch repair_Homo sapiens_hsa034301.44864445
40Fanconi anemia pathway_Homo sapiens_hsa034601.43620042
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39439146
42Arginine biosynthesis_Homo sapiens_hsa002201.37975608
43beta-Alanine metabolism_Homo sapiens_hsa004101.37113855
44Folate biosynthesis_Homo sapiens_hsa007901.35792720
45PPAR signaling pathway_Homo sapiens_hsa033201.35386764
46Tyrosine metabolism_Homo sapiens_hsa003501.34105987
47RNA degradation_Homo sapiens_hsa030181.32489747
48Phenylalanine metabolism_Homo sapiens_hsa003601.30938387
49Basal transcription factors_Homo sapiens_hsa030221.30088494
50Arginine and proline metabolism_Homo sapiens_hsa003301.27816882
51Nitrogen metabolism_Homo sapiens_hsa009101.27789131
52* Carbon metabolism_Homo sapiens_hsa012001.25113498
53Glutathione metabolism_Homo sapiens_hsa004801.24007161
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21629131
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.20163176
56Complement and coagulation cascades_Homo sapiens_hsa046101.17129459
57Phototransduction_Homo sapiens_hsa047441.14917568
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13986221
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11449262
60Nucleotide excision repair_Homo sapiens_hsa034201.08031265
61Retinol metabolism_Homo sapiens_hsa008301.07721556
62Proteasome_Homo sapiens_hsa030501.06727735
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00280267
64* Metabolic pathways_Homo sapiens_hsa011000.97678788
65Sulfur relay system_Homo sapiens_hsa041220.91644938
66Linoleic acid metabolism_Homo sapiens_hsa005910.90559816
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.89199254
68Starch and sucrose metabolism_Homo sapiens_hsa005000.84326214
69RNA transport_Homo sapiens_hsa030130.84052059
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81678522
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.80015359
72DNA replication_Homo sapiens_hsa030300.79763177
73Circadian rhythm_Homo sapiens_hsa047100.79365298
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.78934863
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78807570
76Biosynthesis of amino acids_Homo sapiens_hsa012300.77777304
77Fat digestion and absorption_Homo sapiens_hsa049750.77555608
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76492543
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76468758
80Arachidonic acid metabolism_Homo sapiens_hsa005900.72410260
81Caffeine metabolism_Homo sapiens_hsa002320.71430443
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.70681091
83Ether lipid metabolism_Homo sapiens_hsa005650.70415416
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67002900
85Vitamin B6 metabolism_Homo sapiens_hsa007500.66890538
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65098979
87Vitamin digestion and absorption_Homo sapiens_hsa049770.61465489
88Base excision repair_Homo sapiens_hsa034100.61298992
89N-Glycan biosynthesis_Homo sapiens_hsa005100.61129667
90ABC transporters_Homo sapiens_hsa020100.58287722
91Pentose phosphate pathway_Homo sapiens_hsa000300.57563971
92Staphylococcus aureus infection_Homo sapiens_hsa051500.56934904
93Spliceosome_Homo sapiens_hsa030400.54015800
94Bile secretion_Homo sapiens_hsa049760.53030292
95Type I diabetes mellitus_Homo sapiens_hsa049400.51412870
96Collecting duct acid secretion_Homo sapiens_hsa049660.49993138
97RNA polymerase_Homo sapiens_hsa030200.49479484
98Selenocompound metabolism_Homo sapiens_hsa004500.47703714
99Primary immunodeficiency_Homo sapiens_hsa053400.44651042
100Glycerolipid metabolism_Homo sapiens_hsa005610.42147720
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38319056
102Fatty acid biosynthesis_Homo sapiens_hsa000610.36730694
103Fructose and mannose metabolism_Homo sapiens_hsa000510.36004401
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35546529
105Sphingolipid metabolism_Homo sapiens_hsa006000.31347027
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29885627
107Pyrimidine metabolism_Homo sapiens_hsa002400.26893093
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25750214
109Vibrio cholerae infection_Homo sapiens_hsa051100.25272045
110Regulation of autophagy_Homo sapiens_hsa041400.21752819
111Galactose metabolism_Homo sapiens_hsa000520.21321730
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17829514
113Purine metabolism_Homo sapiens_hsa002300.16103708
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15515667
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.12906886
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11107816
117Rheumatoid arthritis_Homo sapiens_hsa053230.10350674
118Mineral absorption_Homo sapiens_hsa049780.08337660
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04782993
120Renin-angiotensin system_Homo sapiens_hsa046140.04674621
121Ovarian steroidogenesis_Homo sapiens_hsa049130.04116778
122Other glycan degradation_Homo sapiens_hsa005110.03988707

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