MCCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.68401105
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.68401105
3L-phenylalanine metabolic process (GO:0006558)6.48705930
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.48705930
5aromatic amino acid family catabolic process (GO:0009074)6.05825892
6lysine metabolic process (GO:0006553)5.93112696
7lysine catabolic process (GO:0006554)5.93112696
8glyoxylate metabolic process (GO:0046487)5.67837322
9indole-containing compound catabolic process (GO:0042436)5.50764840
10indolalkylamine catabolic process (GO:0046218)5.50764840
11tryptophan catabolic process (GO:0006569)5.50764840
12kynurenine metabolic process (GO:0070189)5.49474403
13cysteine metabolic process (GO:0006534)5.43993602
14sulfur amino acid catabolic process (GO:0000098)5.33430058
15alpha-linolenic acid metabolic process (GO:0036109)5.32315602
16tryptophan metabolic process (GO:0006568)5.22934923
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12953861
18bile acid biosynthetic process (GO:0006699)5.11541961
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.09224694
20amino-acid betaine metabolic process (GO:0006577)5.08256142
21serine family amino acid catabolic process (GO:0009071)4.89842661
22cellular ketone body metabolic process (GO:0046950)4.82830580
23homocysteine metabolic process (GO:0050667)4.82256623
24valine metabolic process (GO:0006573)4.71479282
25fatty acid beta-oxidation (GO:0006635)4.71263153
26short-chain fatty acid metabolic process (GO:0046459)4.64026391
27acetyl-CoA metabolic process (GO:0006084)4.61947271
282-oxoglutarate metabolic process (GO:0006103)4.60118426
29* alpha-amino acid catabolic process (GO:1901606)4.59270814
30urea cycle (GO:0000050)4.54822980
31urea metabolic process (GO:0019627)4.54822980
32aspartate family amino acid catabolic process (GO:0009068)4.54183342
33* branched-chain amino acid catabolic process (GO:0009083)4.53053884
34regulation of triglyceride catabolic process (GO:0010896)4.45129119
35aromatic amino acid family metabolic process (GO:0009072)4.44135177
36fatty acid oxidation (GO:0019395)4.42076176
37imidazole-containing compound metabolic process (GO:0052803)4.41182420
38* cellular amino acid catabolic process (GO:0009063)4.40999080
39carnitine metabolic process (GO:0009437)4.38211719
40bile acid metabolic process (GO:0008206)4.35858066
41lipid oxidation (GO:0034440)4.35371922
42Golgi transport vesicle coating (GO:0048200)4.35057379
43COPI coating of Golgi vesicle (GO:0048205)4.35057379
44fatty acid catabolic process (GO:0009062)4.33336881
45ethanol oxidation (GO:0006069)4.33164974
46* branched-chain amino acid metabolic process (GO:0009081)4.28085293
47nuclear pore complex assembly (GO:0051292)4.27235953
48complement activation, alternative pathway (GO:0006957)4.24924339
49nitrogen cycle metabolic process (GO:0071941)4.24631026
50regulation of translational fidelity (GO:0006450)4.24055475
51high-density lipoprotein particle remodeling (GO:0034375)4.23566120
52cellular modified amino acid catabolic process (GO:0042219)4.22394268
53serine family amino acid metabolic process (GO:0009069)4.20993599
54proline biosynthetic process (GO:0006561)4.18395549
55NADH metabolic process (GO:0006734)4.18081332
56ketone body metabolic process (GO:1902224)4.15845572
57monocarboxylic acid catabolic process (GO:0072329)4.14995728
58glycine metabolic process (GO:0006544)4.11721719
59negative regulation of fibrinolysis (GO:0051918)4.11688887
60* carboxylic acid catabolic process (GO:0046395)4.11060006
61* organic acid catabolic process (GO:0016054)4.11060006
62* biotin metabolic process (GO:0006768)4.08733774
63tyrosine metabolic process (GO:0006570)4.04145967
64regulation of protein activation cascade (GO:2000257)4.02226798
65serine family amino acid biosynthetic process (GO:0009070)4.02045347
66coenzyme catabolic process (GO:0009109)4.00671814
67peptidyl-glutamic acid carboxylation (GO:0017187)4.00228623
68protein carboxylation (GO:0018214)4.00228623
69acylglycerol homeostasis (GO:0055090)3.98086660
70triglyceride homeostasis (GO:0070328)3.98086660
71glutamate metabolic process (GO:0006536)3.97471842
72regulation of fibrinolysis (GO:0051917)3.95947649
73drug transmembrane transport (GO:0006855)3.87471184
74indolalkylamine metabolic process (GO:0006586)3.86789085
75L-serine metabolic process (GO:0006563)3.85672891
76nuclear pore organization (GO:0006999)3.83500297
77reverse cholesterol transport (GO:0043691)3.81831520
78protein-lipid complex remodeling (GO:0034368)3.80934911
79macromolecular complex remodeling (GO:0034367)3.80934911
80plasma lipoprotein particle remodeling (GO:0034369)3.80934911
81urate metabolic process (GO:0046415)3.78060911
82regulation of complement activation (GO:0030449)3.77060020
83regulation of cholesterol esterification (GO:0010872)3.76690466
84cellular biogenic amine catabolic process (GO:0042402)3.76572673
85amine catabolic process (GO:0009310)3.76572673
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.74735508
87fatty acid transmembrane transport (GO:1902001)3.74132994
88benzene-containing compound metabolic process (GO:0042537)3.71749722
89plasma lipoprotein particle clearance (GO:0034381)3.68251114
90negative regulation of sterol transport (GO:0032372)3.66985303
91negative regulation of cholesterol transport (GO:0032375)3.66985303
92DNA unwinding involved in DNA replication (GO:0006268)3.63377716
93tricarboxylic acid metabolic process (GO:0072350)3.62488479
94aldehyde catabolic process (GO:0046185)3.57849454
95dicarboxylic acid biosynthetic process (GO:0043650)3.56047108
96proline metabolic process (GO:0006560)3.51513879
97carnitine shuttle (GO:0006853)3.50135967
98mitotic chromosome condensation (GO:0007076)3.47943382
99* small molecule catabolic process (GO:0044282)3.47709239
100phospholipid homeostasis (GO:0055091)3.46553793
101cellular glucuronidation (GO:0052695)3.46390486
102drug catabolic process (GO:0042737)3.44013297
103oxaloacetate metabolic process (GO:0006107)3.42828653
104folic acid-containing compound biosynthetic process (GO:0009396)3.42455232
105positive regulation of lipid catabolic process (GO:0050996)3.42346642
106bile acid and bile salt transport (GO:0015721)3.40991879
107regulation of cholesterol metabolic process (GO:0090181)3.40702359
108thioester metabolic process (GO:0035383)3.38892766
109acyl-CoA metabolic process (GO:0006637)3.38892766
110arginine metabolic process (GO:0006525)3.34630636
111drug transport (GO:0015893)3.31768204
112positive regulation of fatty acid oxidation (GO:0046321)3.30206354
113response to mercury ion (GO:0046689)3.29623996
114formation of translation preinitiation complex (GO:0001731)3.27938217
115tricarboxylic acid cycle (GO:0006099)3.26414090
116folic acid-containing compound metabolic process (GO:0006760)3.14407025
117bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11257093
118desmosome organization (GO:0002934)3.10906417
119pore complex assembly (GO:0046931)3.09397491
120tetrahydrofolate metabolic process (GO:0046653)3.08947056
121positive regulation of cellular amine metabolic process (GO:0033240)3.03053112
122COPII vesicle coating (GO:0048208)2.95486073
123folic acid metabolic process (GO:0046655)2.95166935
124epoxygenase P450 pathway (GO:0019373)2.93823334
125regulation of RNA export from nucleus (GO:0046831)2.92623335
126peptidyl-lysine dimethylation (GO:0018027)2.91401999
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.90146548
128regulation of histone H3-K27 methylation (GO:0061085)2.86805483
129glutamine family amino acid biosynthetic process (GO:0009084)2.85062780
130iron ion import (GO:0097286)2.83557626
131pentose-phosphate shunt (GO:0006098)2.82103637
132very-low-density lipoprotein particle assembly (GO:0034379)2.81249544
133mitotic sister chromatid cohesion (GO:0007064)2.78666165
134pteridine-containing compound metabolic process (GO:0042558)2.76800710
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.75650385
136ribosome assembly (GO:0042255)2.73208683
137NADPH regeneration (GO:0006740)2.71493889
138pteridine-containing compound biosynthetic process (GO:0042559)2.70624217
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.69616340
140alpha-amino acid biosynthetic process (GO:1901607)2.69046814
141carnitine transmembrane transport (GO:1902603)2.68398810
142DNA strand elongation involved in DNA replication (GO:0006271)2.66647601
143omega-hydroxylase P450 pathway (GO:0097267)2.66556036
144regulation of cholesterol biosynthetic process (GO:0045540)2.66501414
145protein complex localization (GO:0031503)2.66407614
146mitotic nuclear envelope disassembly (GO:0007077)2.64561122
147amino-acid betaine transport (GO:0015838)2.64388129
148carnitine transport (GO:0015879)2.64388129
149quaternary ammonium group transport (GO:0015697)2.63178946
150negative regulation of fatty acid biosynthetic process (GO:0045717)2.62237743
151DNA strand elongation (GO:0022616)2.60049791
152positive regulation of keratinocyte differentiation (GO:0045618)2.59186667
153ER overload response (GO:0006983)2.54480123
154glucose catabolic process (GO:0006007)2.53358247
155maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50705874
156intestinal epithelial cell development (GO:0060576)2.45595691
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44613309
158purine nucleotide transport (GO:0015865)2.43983857
159nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42747086
160sulfur amino acid biosynthetic process (GO:0000097)2.42088803
161monosaccharide biosynthetic process (GO:0046364)2.41428626
162nuclear envelope disassembly (GO:0051081)2.41412662
163membrane disassembly (GO:0030397)2.41412662
164gluconeogenesis (GO:0006094)2.40171073
165hexose biosynthetic process (GO:0019319)2.39383038
166protein localization to chromosome, centromeric region (GO:0071459)2.39246284
167negative regulation of cell size (GO:0045792)2.38805935
168protein retention in ER lumen (GO:0006621)2.38394710
169regulation of centriole replication (GO:0046599)2.37637245
170peptidyl-arginine omega-N-methylation (GO:0035247)2.36808664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.62937040
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.60785547
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.68148874
4E2F7_22180533_ChIP-Seq_HELA_Human6.26588498
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.93856123
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.86903687
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71749331
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62856663
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83731771
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64524971
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.39488454
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.24511222
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68322412
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.39292899
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35535369
16CLOCK_20551151_ChIP-Seq_293T_Human2.31601593
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26447911
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24467099
19ZFX_18555785_ChIP-Seq_MESCs_Mouse2.21200013
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20471073
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15756641
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11958600
23MYC_22102868_ChIP-Seq_BL_Human2.09019797
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06141846
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02152903
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0043759
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.89524738
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86110029
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85866213
30KDM5A_27292631_Chip-Seq_BREAST_Human1.85702400
31XRN2_22483619_ChIP-Seq_HELA_Human1.82956165
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.81825741
33CHD1_26751641_Chip-Seq_LNCaP_Human1.77620593
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76853935
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75347622
36* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74783734
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71038545
38RACK7_27058665_Chip-Seq_MCF-7_Human1.68749405
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66612705
40DCP1A_22483619_ChIP-Seq_HELA_Human1.63900841
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62130630
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60687581
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58982630
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57664077
45GATA1_22025678_ChIP-Seq_K562_Human1.51867280
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49566685
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48794529
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.48130369
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47638643
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44700897
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42807282
52GATA6_25053715_ChIP-Seq_YYC3_Human1.42543216
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.39102057
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.37190819
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37142436
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36848249
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34791440
58* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34426103
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33786989
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33011719
61HTT_18923047_ChIP-ChIP_STHdh_Human1.32088987
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31094083
63GABP_19822575_ChIP-Seq_HepG2_Human1.30641248
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28015611
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24542985
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.23211745
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22938427
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22302911
69TTF2_22483619_ChIP-Seq_HELA_Human1.21829405
70* RUNX1_27514584_Chip-Seq_MCF-7_Human1.21311297
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19381859
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17792787
73* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17599482
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16258260
75ATF3_27146783_Chip-Seq_COLON_Human1.12245665
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12087646
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11608853
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10258829
79TFEB_21752829_ChIP-Seq_HELA_Human1.09403387
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09016064
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08810504
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08583898
83ZNF263_19887448_ChIP-Seq_K562_Human1.07993067
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07734699
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07164736
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06011502
87CIITA_25753668_ChIP-Seq_RAJI_Human1.04360839
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04240651
89* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02714311
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02427820
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01947844
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00476166
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99969511
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98993983
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98918201
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97921288
97GATA4_25053715_ChIP-Seq_YYC3_Human0.96537081
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.96432778
99ELF5_23300383_ChIP-Seq_T47D_Human0.96399208
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96170680
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93598338
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87233484
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85842255
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.82800374
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80467042
106* ESR2_21235772_ChIP-Seq_MCF-7_Human0.77222167
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75970706
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75957430
109* SRF_21415370_ChIP-Seq_HL-1_Mouse0.75898004
110* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73797841
111* AR_21909140_ChIP-Seq_LNCAP_Human0.70891545
112AR_20517297_ChIP-Seq_VCAP_Human0.68755314
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68059394
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67675956
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.65678441
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.65678441
117* RARA_24833708_ChIP-Seq_LIVER_Mouse0.64513730
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62826079
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.62580974
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62401340
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62394137
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62164620
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60882097
124CEBPB_22108803_ChIP-Seq_LS180_Human0.58876784
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58444687
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.58104297
127* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57881576
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.57867310
129* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57031324
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.56687276
131ERG_20517297_ChIP-Seq_VCAP_Human0.55625801
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55360827
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.54860462
134TAF2_19829295_ChIP-Seq_ESCs_Human0.53284253
135* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50489549
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50458022
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50458022
138* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.50227599
139E2F1_18555785_ChIP-Seq_MESCs_Mouse0.50039416
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49757196
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49727869
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.48746448
143MYC_19915707_ChIP-ChIP_AK7_Human0.48586533
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.48364293
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.48300958
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.47598944
147CBP_21632823_ChIP-Seq_H3396_Human0.46939815
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46701915
149LXR_22292898_ChIP-Seq_THP-1_Human0.46341401
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.46025913
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45844840
152FOXA1_25552417_ChIP-Seq_VCAP_Human0.44902193
153BCOR_27268052_Chip-Seq_Bcells_Human0.43767195
154BCAT_22108803_ChIP-Seq_LS180_Human0.43721005
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.43097805
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.42988716
157SOX2_22085726_ChIP-Seq_NPCs_Mouse0.42475897
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41775107
159STAT1_17558387_ChIP-Seq_HELA_Human0.41327539
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.40351450
161NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.39899149
162P53_21459846_ChIP-Seq_SAOS-2_Human0.39634498
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.39557385
164NANOG_18692474_ChIP-Seq_MEFs_Mouse0.38952019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.36046204
2MP0005360_urolithiasis7.04734377
3MP0005365_abnormal_bile_salt5.61687313
4MP0005085_abnormal_gallbladder_physiolo5.57296607
5MP0008875_abnormal_xenobiotic_pharmacok4.43132720
6MP0003806_abnormal_nucleotide_metabolis4.42125868
7MP0010329_abnormal_lipoprotein_level3.37818492
8MP0005332_abnormal_amino_acid3.34590253
9MP0003252_abnormal_bile_duct3.19479975
10MP0010234_abnormal_vibrissa_follicle3.02180599
11MP0002009_preneoplasia3.00385028
12MP0009840_abnormal_foam_cell2.96780612
13MP0003195_calcinosis2.92632258
14MP0004233_abnormal_muscle_weight2.90583134
15MP0003693_abnormal_embryo_hatching2.65109125
16MP0001666_abnormal_nutrient_absorption2.61984187
17MP0005083_abnormal_biliary_tract2.56958700
18MP0008057_abnormal_DNA_replication2.43111382
19MP0004019_abnormal_vitamin_homeostasis2.29789069
20MP0010094_abnormal_chromosome_stability2.27383086
21MP0002118_abnormal_lipid_homeostasis2.22629095
22MP0004957_abnormal_blastocyst_morpholog2.21060931
23MP0002166_altered_tumor_susceptibility2.20756615
24MP0002796_impaired_skin_barrier2.20121577
25MP0003111_abnormal_nucleus_morphology2.09166923
26MP0003191_abnormal_cellular_cholesterol2.08834080
27MP0005670_abnormal_white_adipose2.05957556
28MP0001764_abnormal_homeostasis2.02351333
29MP0002837_dystrophic_cardiac_calcinosis1.97295068
30MP0000609_abnormal_liver_physiology1.94910571
31MP0005319_abnormal_enzyme/_coenzyme1.93838456
32MP0003941_abnormal_skin_development1.84730100
33MP0004130_abnormal_muscle_cell1.82712586
34MP0009643_abnormal_urine_homeostasis1.81560929
35MP0002877_abnormal_melanocyte_morpholog1.81519332
36MP0003186_abnormal_redox_activity1.80710704
37MP0003077_abnormal_cell_cycle1.80226057
38MP0005076_abnormal_cell_differentiation1.78911893
39MP0002876_abnormal_thyroid_physiology1.77752842
40MP0001730_embryonic_growth_arrest1.74011803
41MP0005584_abnormal_enzyme/coenzyme_acti1.70961523
42MP0006036_abnormal_mitochondrial_physio1.65678455
43MP0005501_abnormal_skin_physiology1.65323557
44MP0001881_abnormal_mammary_gland1.62953724
45MP0000627_abnormal_mammary_gland1.56344532
46MP0002138_abnormal_hepatobiliary_system1.56249127
47MP0003868_abnormal_feces_composition1.54790856
48MP0010352_gastrointestinal_tract_polyps1.54044483
49MP0002006_tumorigenesis1.50363915
50MP0004043_abnormal_pH_regulation1.50255503
51MP0000537_abnormal_urethra_morphology1.49605031
52MP0003123_paternal_imprinting1.47556964
53MP0003315_abnormal_perineum_morphology1.47263057
54MP0003984_embryonic_growth_retardation1.39902411
55MP0008932_abnormal_embryonic_tissue1.38246513
56MP0002088_abnormal_embryonic_growth/wei1.37159727
57MP0005380_embryogenesis_phenotype1.37042523
58MP0001672_abnormal_embryogenesis/_devel1.37042523
59MP0001873_stomach_inflammation1.36573169
60MP0003011_delayed_dark_adaptation1.32252095
61MP0005666_abnormal_adipose_tissue1.31441008
62MP0010678_abnormal_skin_adnexa1.29146252
63MP0004782_abnormal_surfactant_physiolog1.25825211
64MP0004858_abnormal_nervous_system1.25256040
65MP0005451_abnormal_body_composition1.24218171
66MP0000350_abnormal_cell_proliferation1.23759276
67MP0002098_abnormal_vibrissa_morphology1.22811461
68MP0001756_abnormal_urination1.21444200
69MP0001697_abnormal_embryo_size1.19507879
70MP0002971_abnormal_brown_adipose1.19465124
71MP0002080_prenatal_lethality1.18564090
72MP0008058_abnormal_DNA_repair1.17546708
73MP0005636_abnormal_mineral_homeostasis1.16728212
74MP0000566_synostosis1.13190990
75MP0005647_abnormal_sex_gland1.11036383
76MP0000383_abnormal_hair_follicle1.09784992
77MP0002396_abnormal_hematopoietic_system1.08996452
78MP0000377_abnormal_hair_follicle1.08455566
79MP0009697_abnormal_copulation1.07353234
80MP0010307_abnormal_tumor_latency1.07291210
81MP0002086_abnormal_extraembryonic_tissu1.06086922
82MP0001727_abnormal_embryo_implantation1.05476057
83MP0001346_abnormal_lacrimal_gland1.05013547
84MP0000598_abnormal_liver_morphology1.04447920
85MP0006035_abnormal_mitochondrial_morpho1.04333743
86MP0005535_abnormal_body_temperature1.04080270
87MP0002078_abnormal_glucose_homeostasis1.03919393
88MP0009780_abnormal_chondrocyte_physiolo1.03237563
89MP0003566_abnormal_cell_adhesion1.02027066
90MP0004197_abnormal_fetal_growth/weight/1.01171915
91MP0003646_muscle_fatigue1.00713986
92MP0001661_extended_life_span0.99384997
93MP0005334_abnormal_fat_pad0.99197025
94MP0003656_abnormal_erythrocyte_physiolo0.96257858
95MP0005330_cardiomyopathy0.94399434
96MP0003183_abnormal_peptide_metabolism0.94279483
97MP0002254_reproductive_system_inflammat0.93765245
98MP0005376_homeostasis/metabolism_phenot0.91693838
99MP0000003_abnormal_adipose_tissue0.91136244
100MP0005266_abnormal_metabolism0.90191069
101MP0008007_abnormal_cellular_replicative0.89855592
102MP0003705_abnormal_hypodermis_morpholog0.89496770
103MP0001216_abnormal_epidermal_layer0.89314306
104MP0009642_abnormal_blood_homeostasis0.85794103
105MP0009703_decreased_birth_body0.85662834
106MP0000467_abnormal_esophagus_morphology0.83057229
107MP0005220_abnormal_exocrine_pancreas0.83036055
108MP0002085_abnormal_embryonic_tissue0.82086628
109MP0003690_abnormal_glial_cell0.80118099
110MP0009764_decreased_sensitivity_to0.80038711
111MP0000747_muscle_weakness0.79791027
112MP0009763_increased_sensitivity_to0.79779491
113MP0003943_abnormal_hepatobiliary_system0.79475980
114MP0000604_amyloidosis0.78928724
115MP0000313_abnormal_cell_death0.77387227
116MP0005084_abnormal_gallbladder_morpholo0.76759737
117MP0002136_abnormal_kidney_physiology0.75384698
118MP0005375_adipose_tissue_phenotype0.74293750
119MP0002084_abnormal_developmental_patter0.73518186
120MP0003329_amyloid_beta_deposits0.72425481
121MP0005408_hypopigmentation0.72188276
122MP0008469_abnormal_protein_level0.70461859
123MP0000230_abnormal_systemic_arterial0.69708680
124MP0009115_abnormal_fat_cell0.68520160
125MP0002269_muscular_atrophy0.67794790
126MP0004215_abnormal_myocardial_fiber0.66869673
127MP0009765_abnormal_xenobiotic_induced0.66233557
128MP0005448_abnormal_energy_balance0.65764923
129MP0003638_abnormal_response/metabolism_0.61731020
130MP0003959_abnormal_lean_body0.60676824
131MP0004185_abnormal_adipocyte_glucose0.60198762
132MP0001765_abnormal_ion_homeostasis0.60145195
133MP0006138_congestive_heart_failure0.59290611
134MP0003953_abnormal_hormone_level0.58467509
135MP0004147_increased_porphyrin_level0.58308606
136MP0004036_abnormal_muscle_relaxation0.58018196
137MP0002970_abnormal_white_adipose0.57279452
138MP0001544_abnormal_cardiovascular_syste0.56571705
139MP0005385_cardiovascular_system_phenoty0.56571705
140MP0003221_abnormal_cardiomyocyte_apopto0.54990278
141MP0005395_other_phenotype0.53608186
142MP0000751_myopathy0.52911264
143MP0003718_maternal_effect0.50611863
144MP0004087_abnormal_muscle_fiber0.48025203
145MP0000749_muscle_degeneration0.46184170
146MP0005058_abnormal_lysosome_morphology0.45802362
147MP0005620_abnormal_muscle_contractility0.45618064
148MP0002972_abnormal_cardiac_muscle0.45127919
149MP0004084_abnormal_cardiac_muscle0.44383427
150MP0009672_abnormal_birth_weight0.43779833
151MP0009384_cardiac_valve_regurgitation0.43647404
152MP0002332_abnormal_exercise_endurance0.43481148
153MP0008775_abnormal_heart_ventricle0.40957074
154MP0002168_other_aberrant_phenotype0.40334453
155MP0003137_abnormal_impulse_conducting0.39626413
156MP0001853_heart_inflammation0.39585705
157MP0004264_abnormal_extraembryonic_tissu0.38438128
158MP0010630_abnormal_cardiac_muscle0.38166287
159MP0009053_abnormal_anal_canal0.37186038

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94146532
2Intrahepatic cholestasis (HP:0001406)5.93513862
3* Hyperglycinuria (HP:0003108)5.55856965
4Deep venous thrombosis (HP:0002625)5.21602414
5Xanthomatosis (HP:0000991)5.16151734
6* Abnormality of glycine metabolism (HP:0010895)5.15252885
7* Abnormality of serine family amino acid metabolism (HP:0010894)5.15252885
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.10438967
9* Hyperammonemia (HP:0001987)5.10382521
10* Ketosis (HP:0001946)5.04042946
11Hyperglycinemia (HP:0002154)5.00517775
12Hypobetalipoproteinemia (HP:0003563)4.86551538
13Hyperlipoproteinemia (HP:0010980)4.73685728
14Abnormality of fatty-acid metabolism (HP:0004359)4.60153963
15Prolonged partial thromboplastin time (HP:0003645)4.52297213
16Hypoglycemic coma (HP:0001325)4.52275967
17* Ketoacidosis (HP:0001993)4.42310392
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08784715
19Hypolipoproteinemia (HP:0010981)4.01056389
20Right ventricular cardiomyopathy (HP:0011663)3.99894502
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.90718579
22Complement deficiency (HP:0004431)3.90008093
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.89178835
24Dicarboxylic aciduria (HP:0003215)3.82802848
25Abnormality of dicarboxylic acid metabolism (HP:0010995)3.82802848
26Septate vagina (HP:0001153)3.79022284
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.76817975
28Hypoalphalipoproteinemia (HP:0003233)3.74697398
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.70690956
30Epidermoid cyst (HP:0200040)3.64510131
31Delayed CNS myelination (HP:0002188)3.58869782
32Gout (HP:0001997)3.54311320
33Sparse lateral eyebrow (HP:0005338)3.47291380
34Abnormality of methionine metabolism (HP:0010901)3.46361601
35Abnormality of serum amino acid levels (HP:0003112)3.45664975
36Fat malabsorption (HP:0002630)3.45034300
37Flat acetabular roof (HP:0003180)3.44317544
38Lethargy (HP:0001254)3.43683466
39Generalized aminoaciduria (HP:0002909)3.36322359
40Metabolic acidosis (HP:0001942)3.34664694
41Cerebral edema (HP:0002181)3.28149251
42Joint hemorrhage (HP:0005261)3.15459933
43Asymmetry of the thorax (HP:0001555)3.12366007
44Abnormality of purine metabolism (HP:0004352)3.07645648
45Abnormality of the common coagulation pathway (HP:0010990)3.00345845
46Chromsome breakage (HP:0040012)2.98317408
47Proximal tubulopathy (HP:0000114)2.97970478
48Abnormality of nucleobase metabolism (HP:0010932)2.96019810
49Myoglobinuria (HP:0002913)2.85218562
50Hyperbilirubinemia (HP:0002904)2.84574013
51Abnormality of the intrinsic pathway (HP:0010989)2.82236743
52Progressive muscle weakness (HP:0003323)2.81532153
53Vomiting (HP:0002013)2.80285595
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74931050
55Abnormality of pyrimidine metabolism (HP:0004353)2.72768134
56Steatorrhea (HP:0002570)2.71155830
57Hypercholesterolemia (HP:0003124)2.67412891
58J-shaped sella turcica (HP:0002680)2.67358185
59Conjugated hyperbilirubinemia (HP:0002908)2.66428710
60Abnormality of complement system (HP:0005339)2.65557366
61Hyperuricemia (HP:0002149)2.61734448
62Increased purine levels (HP:0004368)2.61734448
63Hepatic necrosis (HP:0002605)2.60283224
64Advanced eruption of teeth (HP:0006288)2.57210027
65Multiple enchondromatosis (HP:0005701)2.56965718
66Testicular atrophy (HP:0000029)2.54058705
67Microglossia (HP:0000171)2.49199688
68Acute encephalopathy (HP:0006846)2.47516109
69Abnormal tarsal ossification (HP:0008369)2.46274411
70Nausea (HP:0002018)2.44653698
71Renal cortical cysts (HP:0000803)2.44626679
72Glycosuria (HP:0003076)2.39665004
73Abnormality of urine glucose concentration (HP:0011016)2.39665004
74Hepatocellular carcinoma (HP:0001402)2.38724831
75Back pain (HP:0003418)2.35388504
76Vascular calcification (HP:0004934)2.33114460
77Brushfield spots (HP:0001088)2.32460783
78Hypoglycemic seizures (HP:0002173)2.31690081
79Skin nodule (HP:0200036)2.31457838
80Neonatal hypoglycemia (HP:0001998)2.30254453
81Pancreatitis (HP:0001733)2.28183534
82Hydroxyprolinuria (HP:0003080)2.26164361
83Abnormality of proline metabolism (HP:0010907)2.26164361
84Late onset (HP:0003584)2.26074230
85Germ cell neoplasia (HP:0100728)2.24226970
86Rhabdomyolysis (HP:0003201)2.24164591
87Irritability (HP:0000737)2.23926341
88Spastic diplegia (HP:0001264)2.21606754
89Hyperinsulinemic hypoglycemia (HP:0000825)2.21493438
90Methylmalonic aciduria (HP:0012120)2.21382066
91Enlarged kidneys (HP:0000105)2.20501833
92Neonatal onset (HP:0003623)2.20227038
93Sensorimotor neuropathy (HP:0007141)2.17019658
94Microvesicular hepatic steatosis (HP:0001414)2.16611488
95Abnormal gallbladder physiology (HP:0012438)2.16118115
96Cholecystitis (HP:0001082)2.16118115
97Abnormality of glycolysis (HP:0004366)2.15866961
98Increased serum pyruvate (HP:0003542)2.15866961
99Opisthotonus (HP:0002179)2.15819508
100Malnutrition (HP:0004395)2.15580113
101Increased muscle lipid content (HP:0009058)2.15538618
102Macroorchidism (HP:0000053)2.15000579
103Alkalosis (HP:0001948)2.14796278
104Abnormal gallbladder morphology (HP:0012437)2.13302061
105Dysmetric saccades (HP:0000641)2.13038306
106Cholelithiasis (HP:0001081)2.09750743
107Insidious onset (HP:0003587)2.09141743
108Termporal pattern (HP:0011008)2.09141743
109Hypoparathyroidism (HP:0000829)2.09078042
110Hyperacusis (HP:0010780)2.07321468
111Cardiovascular calcification (HP:0011915)2.06534044
112Myocardial infarction (HP:0001658)2.02097920
113Papillary thyroid carcinoma (HP:0002895)2.01495512
114Lactic acidosis (HP:0003128)2.00669478
115Reduced antithrombin III activity (HP:0001976)2.00191393
116Pseudobulbar signs (HP:0002200)2.00049025
117Testicular neoplasm (HP:0010788)1.99797693
118Unilateral renal agenesis (HP:0000122)1.99276561
119Abnormality of the gastric mucosa (HP:0004295)1.99171358
120Lip pit (HP:0100267)1.98484757
121Abnormal cartilage morphology (HP:0002763)1.97789516
122Breast carcinoma (HP:0003002)1.97332003
123Hypertriglyceridemia (HP:0002155)1.95838666
124Micronodular cirrhosis (HP:0001413)1.95649708
125Ventricular tachycardia (HP:0004756)1.94769976
126Confusion (HP:0001289)1.92664036
127Hemorrhage of the eye (HP:0011885)1.90422712
128Spontaneous abortion (HP:0005268)1.90227302
129Respiratory distress (HP:0002098)1.88841200
130Elevated hepatic transaminases (HP:0002910)1.87153717
131Abnormality of the thoracic spine (HP:0100711)1.86125372
132Reticulocytosis (HP:0001923)1.85105535
133Palpitations (HP:0001962)1.84787390
134Progressive external ophthalmoplegia (HP:0000590)1.84266515
135Ragged-red muscle fibers (HP:0003200)1.83600814
136Hyperglycemia (HP:0003074)1.82977863
137Distal lower limb muscle weakness (HP:0009053)1.82724274
138Bundle branch block (HP:0011710)1.82287381
139Systemic lupus erythematosus (HP:0002725)1.82263465
140Abnormality of vitamin metabolism (HP:0100508)1.80393444
141Abnormal foot bone ossification (HP:0010675)1.78992502
142Overlapping toe (HP:0001845)1.77233477
143Atrioventricular block (HP:0001678)1.76042574
144Hepatocellular necrosis (HP:0001404)1.75932282
145Abnormality of the gallbladder (HP:0005264)1.75868380
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.75311846
147Esophageal varix (HP:0002040)1.71707727
148Sudden death (HP:0001699)1.71508379
149Exercise-induced myalgia (HP:0003738)1.70915097
150Pili torti (HP:0003777)1.70882319
151Abnormal hair laboratory examination (HP:0003328)1.70268970
152Deep philtrum (HP:0002002)1.69331427
153Bifid scrotum (HP:0000048)1.69036559
154Abnormality of the umbilical cord (HP:0010881)1.69008828
155Abnormality of carpal bone ossification (HP:0006257)1.65997448
156Increased nuchal translucency (HP:0010880)1.62530880
157Anal stenosis (HP:0002025)1.61815530
158Nephroblastoma (Wilms tumor) (HP:0002667)1.61282299
159Deviation of the thumb (HP:0009603)1.60096826
160Thyroid carcinoma (HP:0002890)1.58728610
161Hypokinesia (HP:0002375)1.58609367
162Neonatal death (HP:0003811)1.58541572
163Hyperthyroidism (HP:0000836)1.58460205
164Curly hair (HP:0002212)1.58276491
165Abnormality of the salivary glands (HP:0010286)1.57778199
166Missing ribs (HP:0000921)1.54726782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.75933778
2SIK14.07250447
3SMG14.00232083
4EEF2K3.92614083
5SCYL23.60573116
6CDK123.50026053
7ERN13.04943463
8PDK32.87899014
9PDK42.87899014
10FGFR42.85281810
11RPS6KB22.78560392
12INSRR2.61440376
13TRIB32.59893591
14VRK22.42832944
15ICK2.20684446
16PKN22.20507902
17NEK12.20174044
18LMTK22.07710576
19FLT32.07517566
20PINK11.95313692
21TAF11.92485072
22CDK71.84537640
23PDK21.83604907
24TTK1.78463420
25WNK41.73501578
26WNK31.72149795
27PHKG21.68815042
28PHKG11.68815042
29NME21.62337745
30MYLK1.50870564
31PBK1.49886345
32ERBB41.43465718
33PIK3CG1.37238931
34PRKAA21.36498238
35MST1R1.33171720
36SRPK11.29698911
37MAPK111.29658150
38OXSR11.29467322
39CAMK1D1.26781716
40STK38L1.22424632
41PRKD31.22319298
42TTN1.20101578
43AKT31.15824925
44TSSK61.12919913
45IRAK31.11392181
46MUSK1.09158994
47CDC71.05952114
48OBSCN1.02769770
49FRK1.01992591
50MAP2K40.99276904
51FER0.97986017
52KDR0.97085570
53EIF2AK30.95971820
54ABL20.95053158
55BRD40.94803908
56TIE10.94539597
57LATS10.91759505
58MET0.91673282
59TAOK30.90795447
60PTK60.90378045
61PRKAA10.90069779
62PAK40.86866065
63EPHA20.82716198
64NEK60.82362939
65ATR0.82281643
66MAPK120.79090077
67EIF2AK20.78865027
68BRSK20.78864083
69ALK0.78581661
70MAP2K30.78057119
71CHEK20.76389374
72BUB10.75611153
73TYK20.75484797
74CDK90.75217956
75PIK3CA0.74963713
76AURKB0.74681346
77DMPK0.74215075
78TNK20.73545502
79PRKACG0.72574053
80LATS20.71807082
81MAP3K100.71116519
82MAPKAPK30.70899630
83FGFR20.70891507
84MAP3K30.70504375
85SGK2230.68956734
86SGK4940.68956734
87CHEK10.68346225
88MAPKAPK50.67276062
89MELK0.66892471
90NEK90.66581548
91ARAF0.65540005
92AURKA0.64144011
93SGK20.64032070
94JAK20.63981494
95AKT20.63821443
96PRKCI0.63567458
97BRSK10.62936935
98RPS6KB10.62498486
99PDGFRA0.62023816
100CAMK2G0.61383050
101PRKCZ0.58466435
102STK390.55973642
103MAP3K70.55645330
104MAPK40.55484288
105MAP3K90.54529466
106RPS6KA40.53086827
107SGK30.52108934
108STK160.51414561
109MAPK70.50983327
110PAK30.50650482
111EPHB10.50458609
112FGFR30.50344358
113PDPK10.48726054
114ILK0.48254237
115IRAK10.48238979
116PIM20.48238704
117CDK10.48167618
118MAP3K130.44576716
119CDK20.44454560
120IRAK20.44134620
121WEE10.43712115
122CDK80.43658254
123GSK3A0.43576980
124DAPK10.41006127
125DAPK20.40848414
126STK40.40266685
127ATM0.40250700
128CSNK1E0.40193973
129MAP2K10.40153601
130IGF1R0.39640352
131GRK60.39478671
132MAP2K60.39299350
133CAMK1G0.39232359
134BRAF0.38868820
135ERBB20.37787873
136MAP3K80.37290457
137PRKACB0.37138827
138CSNK2A20.35225631
139RET0.34745435
140PRKACA0.33124354
141MST40.33102412
142STK30.32456362
143CHUK0.32094932
144NME10.32004107
145CSF1R0.31890488
146MAPK150.31854510
147EPHA30.29614888
148MTOR0.29088095
149CDK60.28362659
150CDK40.26172080
151MAP3K110.24426062
152PRKCA0.24233413
153EIF2AK10.24071506
154PRKCG0.23758187
155PRKCQ0.23545289
156JAK10.23058869
157PKN10.21969071
158DYRK1B0.21544462
159PDK10.21449828
160PTK20.21328992
161PRKCD0.21260248
162GRK10.21123285
163MAP2K20.20943490
164LRRK20.19538809
165CAMK2D0.19201021

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52714141
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.17456521
3Fatty acid degradation_Homo sapiens_hsa000713.05387600
4Propanoate metabolism_Homo sapiens_hsa006403.00143439
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93906056
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90601184
7Nitrogen metabolism_Homo sapiens_hsa009102.88281756
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79583278
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.62102327
10Tryptophan metabolism_Homo sapiens_hsa003802.56323636
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55841349
12Butanoate metabolism_Homo sapiens_hsa006502.53089045
13Arginine biosynthesis_Homo sapiens_hsa002202.49949332
14Fatty acid metabolism_Homo sapiens_hsa012122.40459664
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36631946
16Peroxisome_Homo sapiens_hsa041462.27533118
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15117321
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09997314
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08370465
20PPAR signaling pathway_Homo sapiens_hsa033202.05435932
21Pyruvate metabolism_Homo sapiens_hsa006201.96525461
22beta-Alanine metabolism_Homo sapiens_hsa004101.91828320
23Complement and coagulation cascades_Homo sapiens_hsa046101.81276563
24DNA replication_Homo sapiens_hsa030301.78287109
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75846902
26Carbon metabolism_Homo sapiens_hsa012001.74575777
27Fatty acid elongation_Homo sapiens_hsa000621.70319889
28Histidine metabolism_Homo sapiens_hsa003401.63194343
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57992591
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57633991
31Chemical carcinogenesis_Homo sapiens_hsa052041.56300675
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52879210
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50431087
34Caffeine metabolism_Homo sapiens_hsa002321.47122564
35Sulfur metabolism_Homo sapiens_hsa009201.46666560
36Biosynthesis of amino acids_Homo sapiens_hsa012301.46109070
37Selenocompound metabolism_Homo sapiens_hsa004501.46090853
38Thyroid cancer_Homo sapiens_hsa052161.44337349
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.42238659
40Phenylalanine metabolism_Homo sapiens_hsa003601.40906834
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.39307152
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28936717
43Retinol metabolism_Homo sapiens_hsa008301.28145923
44Bile secretion_Homo sapiens_hsa049761.25872620
45Tyrosine metabolism_Homo sapiens_hsa003501.25260882
46Base excision repair_Homo sapiens_hsa034101.23596198
47Starch and sucrose metabolism_Homo sapiens_hsa005001.21457658
48Mismatch repair_Homo sapiens_hsa034301.13803334
49RNA transport_Homo sapiens_hsa030131.12196660
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11733325
51Arginine and proline metabolism_Homo sapiens_hsa003301.10862348
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.10453730
53Folate biosynthesis_Homo sapiens_hsa007901.08925597
54Fat digestion and absorption_Homo sapiens_hsa049751.08392183
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04195492
56Glycerolipid metabolism_Homo sapiens_hsa005610.99926187
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98575827
58Vitamin digestion and absorption_Homo sapiens_hsa049770.97650993
59Non-homologous end-joining_Homo sapiens_hsa034500.95633671
60Fatty acid biosynthesis_Homo sapiens_hsa000610.95245619
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93102802
62Staphylococcus aureus infection_Homo sapiens_hsa051500.92094577
63ABC transporters_Homo sapiens_hsa020100.90629616
64mRNA surveillance pathway_Homo sapiens_hsa030150.90177249
65Spliceosome_Homo sapiens_hsa030400.89397123
66Steroid biosynthesis_Homo sapiens_hsa001000.88338675
67Vitamin B6 metabolism_Homo sapiens_hsa007500.86941342
68Lysine degradation_Homo sapiens_hsa003100.85569003
69Glutathione metabolism_Homo sapiens_hsa004800.85124601
70Sulfur relay system_Homo sapiens_hsa041220.84652922
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.82174678
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80580224
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79802414
74Endometrial cancer_Homo sapiens_hsa052130.79611499
75Nucleotide excision repair_Homo sapiens_hsa034200.79270674
76Cell cycle_Homo sapiens_hsa041100.76266700
77N-Glycan biosynthesis_Homo sapiens_hsa005100.75227683
78Pentose phosphate pathway_Homo sapiens_hsa000300.74750402
79Prostate cancer_Homo sapiens_hsa052150.69999110
80Bladder cancer_Homo sapiens_hsa052190.66326172
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64479241
82One carbon pool by folate_Homo sapiens_hsa006700.63434805
83* Metabolic pathways_Homo sapiens_hsa011000.62152535
84Non-small cell lung cancer_Homo sapiens_hsa052230.61857210
85Chronic myeloid leukemia_Homo sapiens_hsa052200.58731300
86Fructose and mannose metabolism_Homo sapiens_hsa000510.55816312
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53607951
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48415821
89Acute myeloid leukemia_Homo sapiens_hsa052210.47847753
90mTOR signaling pathway_Homo sapiens_hsa041500.44343198
91Pancreatic cancer_Homo sapiens_hsa052120.43168101
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40889473
93Oxidative phosphorylation_Homo sapiens_hsa001900.40447919
94Galactose metabolism_Homo sapiens_hsa000520.39548262
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39042619
96Adherens junction_Homo sapiens_hsa045200.38045525
97Proteasome_Homo sapiens_hsa030500.37921059
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.37125893
99Parkinsons disease_Homo sapiens_hsa050120.33361529
100Homologous recombination_Homo sapiens_hsa034400.33247972
101Insulin resistance_Homo sapiens_hsa049310.31710075
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27622906
103AMPK signaling pathway_Homo sapiens_hsa041520.22307285
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.20407133
105Glucagon signaling pathway_Homo sapiens_hsa049220.19179483
106Linoleic acid metabolism_Homo sapiens_hsa005910.18078219
107Alzheimers disease_Homo sapiens_hsa050100.12556179
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07669166
109Prion diseases_Homo sapiens_hsa050200.06671961
110Insulin signaling pathway_Homo sapiens_hsa049100.02085369
111Arachidonic acid metabolism_Homo sapiens_hsa005900.01896506
112Regulation of autophagy_Homo sapiens_hsa041400.01418695
113Huntingtons disease_Homo sapiens_hsa050160.00976126
114Renin-angiotensin system_Homo sapiens_hsa046140.00114561
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1728472
116Protein export_Homo sapiens_hsa03060-0.1713291
117Pyrimidine metabolism_Homo sapiens_hsa00240-0.1607415
118Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1514872
119Other glycan degradation_Homo sapiens_hsa00511-0.1352896
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1219616
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1053611
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0922431
123Protein digestion and absorption_Homo sapiens_hsa04974-0.0568173
124Cardiac muscle contraction_Homo sapiens_hsa04260-0.0473658
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0214236
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0042652

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