MC5R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.76354687
2acrosome reaction (GO:0007340)9.16496930
3fusion of sperm to egg plasma membrane (GO:0007342)9.12602321
4ribosomal small subunit assembly (GO:0000028)8.20516713
5plasma membrane fusion (GO:0045026)7.81020567
6spermatid nucleus differentiation (GO:0007289)7.43669267
7rRNA methylation (GO:0031167)7.12058242
8protein polyglutamylation (GO:0018095)6.69943467
9single strand break repair (GO:0000012)6.68836930
10sperm capacitation (GO:0048240)6.58937851
11sperm-egg recognition (GO:0035036)6.27492671
12rRNA modification (GO:0000154)6.16187091
13protein targeting to Golgi (GO:0000042)6.12680382
14spermatid development (GO:0007286)6.10357821
15establishment of protein localization to Golgi (GO:0072600)5.97538794
16axonemal dynein complex assembly (GO:0070286)5.95595134
17multicellular organism reproduction (GO:0032504)5.92997897
18retrograde transport, vesicle recycling within Golgi (GO:0000301)5.70951914
19viral transcription (GO:0019083)5.70078372
20centriole replication (GO:0007099)5.65826363
21DNA packaging (GO:0006323)5.64445646
22chromosome condensation (GO:0030261)5.63193531
23binding of sperm to zona pellucida (GO:0007339)5.48742774
24protein localization to Golgi apparatus (GO:0034067)5.36533281
25calcium ion-dependent exocytosis (GO:0017156)5.35462609
26reproduction (GO:0000003)5.34339034
27translational termination (GO:0006415)5.20134182
28cell-cell recognition (GO:0009988)5.15650090
29DNA deamination (GO:0045006)5.14729437
30daunorubicin metabolic process (GO:0044597)5.09330436
31polyketide metabolic process (GO:0030638)5.09330436
32doxorubicin metabolic process (GO:0044598)5.09330436
33definitive hemopoiesis (GO:0060216)5.06365811
34microtubule depolymerization (GO:0007019)5.04758552
35spermatogenesis (GO:0007283)4.98472808
36male gamete generation (GO:0048232)4.98051854
37phosphatidylethanolamine biosynthetic process (GO:0006646)4.97641786
38microtubule polymerization or depolymerization (GO:0031109)4.97546372
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93393347
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93393347
41regulation of cilium movement (GO:0003352)4.87651051
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.73423649
43phosphatidylethanolamine metabolic process (GO:0046337)4.67554391
44epithelial cilium movement (GO:0003351)4.64859063
45translational elongation (GO:0006414)4.64590052
46cotranslational protein targeting to membrane (GO:0006613)4.62117726
47platelet dense granule organization (GO:0060155)4.59955842
48gamete generation (GO:0007276)4.58643333
49protein targeting to ER (GO:0045047)4.58126347
50regulation of Rab GTPase activity (GO:0032313)4.54207297
51positive regulation of Rab GTPase activity (GO:0032851)4.54207297
52sexual reproduction (GO:0019953)4.52785501
53ribosomal small subunit biogenesis (GO:0042274)4.48173398
54cilium or flagellum-dependent cell motility (GO:0001539)4.43499516
55centriole assembly (GO:0098534)4.35560275
56protein localization to endoplasmic reticulum (GO:0070972)4.34859317
57establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34620346
58telomere maintenance via semi-conservative replication (GO:0032201)4.30709772
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.22537145
60lymphoid progenitor cell differentiation (GO:0002320)4.18958962
61cellular ketone body metabolic process (GO:0046950)4.14247880
62cilium movement (GO:0003341)4.14021035
63positive regulation of B cell differentiation (GO:0045579)4.11014470
64negative regulation of inclusion body assembly (GO:0090084)4.04218164
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99637228
66single fertilization (GO:0007338)3.97063050
67cell wall macromolecule catabolic process (GO:0016998)3.96790469
68antigen processing and presentation of endogenous antigen (GO:0019883)3.94396812
69endosome to pigment granule transport (GO:0043485)3.93303078
70endosome to melanosome transport (GO:0035646)3.93303078
71viral life cycle (GO:0019058)3.92786834
72DNA strand elongation involved in DNA replication (GO:0006271)3.90242382
73motile cilium assembly (GO:0044458)3.88019414
74cell wall macromolecule metabolic process (GO:0044036)3.87300278
75cellular protein complex disassembly (GO:0043624)3.85829122
76maturation of SSU-rRNA (GO:0030490)3.85735300
77regulation of centriole replication (GO:0046599)3.82484587
78DNA strand elongation (GO:0022616)3.82431775
79toxin transport (GO:1901998)3.79307905
80histamine transport (GO:0051608)3.77644327
81ketone body metabolic process (GO:1902224)3.76998339
82musculoskeletal movement (GO:0050881)3.69113774
83multicellular organismal movement (GO:0050879)3.69113774
84microtubule severing (GO:0051013)3.67946445
85negative regulation of Rho protein signal transduction (GO:0035024)3.67830187
86translational initiation (GO:0006413)3.65058588
87seminiferous tubule development (GO:0072520)3.63993176
88multicellular organismal reproductive process (GO:0048609)3.62596165
89megakaryocyte development (GO:0035855)3.61539591
90microtubule nucleation (GO:0007020)3.57376906
91L-fucose catabolic process (GO:0042355)3.56985874
92fucose catabolic process (GO:0019317)3.56985874
93L-fucose metabolic process (GO:0042354)3.56985874
94antigen processing and presentation via MHC class Ib (GO:0002475)3.56589458
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56054329
96protein complex disassembly (GO:0043241)3.53711445
97telomere maintenance via recombination (GO:0000722)3.52886274
98necroptotic process (GO:0070266)3.49273915
99germ cell development (GO:0007281)3.49064894
100fertilization (GO:0009566)3.48767286
101mast cell activation (GO:0045576)3.46122272
102telomere maintenance via telomere lengthening (GO:0010833)3.45645803
103RNA destabilization (GO:0050779)3.45354537
104cellular process involved in reproduction in multicellular organism (GO:0022412)3.41623102
105regulation of erythrocyte differentiation (GO:0045646)3.39983907
106execution phase of apoptosis (GO:0097194)3.37151147
107DNA unwinding involved in DNA replication (GO:0006268)3.37001080
108ribosomal large subunit biogenesis (GO:0042273)3.32593056
109chromatin silencing (GO:0006342)3.32560228
110intra-S DNA damage checkpoint (GO:0031573)3.32293251
111nuclear-transcribed mRNA catabolic process (GO:0000956)3.30016502
112regulation of microtubule-based movement (GO:0060632)3.29832841
113negative regulation of erythrocyte differentiation (GO:0045647)3.29517949
114axoneme assembly (GO:0035082)3.28339637
115male meiosis I (GO:0007141)3.28317277
116glycerol ether metabolic process (GO:0006662)3.28036577
117macromolecular complex disassembly (GO:0032984)3.27666961
118regulation of interleukin-5 production (GO:0032674)3.27577246
119response to interferon-beta (GO:0035456)3.24729685
120programmed necrotic cell death (GO:0097300)3.23749417
121detection of light stimulus involved in sensory perception (GO:0050962)3.23256311
122detection of light stimulus involved in visual perception (GO:0050908)3.23256311
123DNA methylation involved in gamete generation (GO:0043046)3.22093423
124aminoglycoside antibiotic metabolic process (GO:0030647)3.21578915
125piRNA metabolic process (GO:0034587)3.20532132
126DNA replication initiation (GO:0006270)3.19655899
127secretory granule organization (GO:0033363)3.19458422
128embryonic hemopoiesis (GO:0035162)3.19132311
129negative regulation of phagocytosis (GO:0050765)3.18491853
130mRNA catabolic process (GO:0006402)3.15126129
131nucleotide-excision repair, DNA gap filling (GO:0006297)3.14785241
132positive regulation of guanylate cyclase activity (GO:0031284)3.12408289
133regulation of B cell differentiation (GO:0045577)3.11699062
134mitotic recombination (GO:0006312)3.09940743
135positive regulation of granulocyte differentiation (GO:0030854)3.09727839
136ether metabolic process (GO:0018904)3.09193415
137regulation of mesoderm development (GO:2000380)3.08855176
138pseudouridine synthesis (GO:0001522)3.07387190
139ribonucleoprotein complex biogenesis (GO:0022613)3.00695645
140RNA catabolic process (GO:0006401)3.00603353
141mast cell activation involved in immune response (GO:0002279)3.00495623
142mast cell degranulation (GO:0043303)3.00495623
143protein targeting to membrane (GO:0006612)2.99435181
144regulation of transcription involved in cell fate commitment (GO:0060850)2.99112854
145IMP biosynthetic process (GO:0006188)2.98622732
146regulation of establishment of cell polarity (GO:2000114)2.97220217
147nephron epithelium morphogenesis (GO:0072088)2.93821338
148nephron tubule morphogenesis (GO:0072078)2.93821338
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92404300
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92404300
151necrotic cell death (GO:0070265)2.91862174
152negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.89542553
153peptidyl-threonine dephosphorylation (GO:0035970)2.89263601
154nucleobase biosynthetic process (GO:0046112)2.88920353
155cellular response to thyroid hormone stimulus (GO:0097067)2.87255499
156positive regulation of respiratory burst (GO:0060267)2.87200851
157organic cation transport (GO:0015695)2.85629016
158regulation of guanylate cyclase activity (GO:0031282)2.85137667
159positive regulation of gamma-delta T cell activation (GO:0046645)2.84997081
160IMP metabolic process (GO:0046040)2.84955470
161Golgi to endosome transport (GO:0006895)2.84927022
162defense response to protozoan (GO:0042832)2.84740770
163translesion synthesis (GO:0019985)2.84251987
164response to protozoan (GO:0001562)2.84230888
165nucleus organization (GO:0006997)2.83542131
166C4-dicarboxylate transport (GO:0015740)2.82845498
167glomerular visceral epithelial cell development (GO:0072015)2.82514018
168regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82490781
169male meiosis (GO:0007140)2.79514255
170cell recognition (GO:0008037)2.79395490
171intra-Golgi vesicle-mediated transport (GO:0006891)2.75164170
172mannosylation (GO:0097502)2.74586540
173purine nucleobase biosynthetic process (GO:0009113)2.73365833
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72837731
175viral mRNA export from host cell nucleus (GO:0046784)2.72498115
176translation (GO:0006412)2.71901335
177T cell homeostasis (GO:0043029)2.71168295
178negative regulation of transcription by competitive promoter binding (GO:0010944)2.71075437
179detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.71020639
180CTP biosynthetic process (GO:0006241)2.69684045
181CTP metabolic process (GO:0046036)2.69684045
182NAD biosynthetic process (GO:0009435)2.69586494
183glomerular epithelial cell development (GO:0072310)2.68958907
184spinal cord motor neuron differentiation (GO:0021522)2.68358522
185mitochondrial fission (GO:0000266)2.67611900
186cilium organization (GO:0044782)2.66991762
187coenzyme catabolic process (GO:0009109)2.65912538
188regulation of necroptotic process (GO:0060544)2.64587923
189cilium assembly (GO:0042384)2.64299531
190positive regulation of natural killer cell differentiation (GO:0032825)2.64226163
191deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.63944587
192somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63530364
193isotype switching (GO:0045190)2.63530364
194somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63530364
195regulation of necrotic cell death (GO:0010939)2.62263879
196positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61079461
197pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60187431
198meiosis I (GO:0007127)2.58974684
199response to pheromone (GO:0019236)11.7824270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73424199
2SCL_19346495_ChIP-Seq_HPC-7_Human4.00939849
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47161067
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.36727135
5ZNF274_21170338_ChIP-Seq_K562_Hela3.09861473
6GATA1_22025678_ChIP-Seq_K562_Human3.03737297
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.01499467
8TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.84792903
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84509719
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84302468
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82024297
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76511375
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.69375163
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.63054952
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.61486371
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61486371
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60974245
18FUS_26573619_Chip-Seq_HEK293_Human2.60435635
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56082674
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51422808
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.44281400
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41713069
23VDR_22108803_ChIP-Seq_LS180_Human2.41671357
24ER_23166858_ChIP-Seq_MCF-7_Human2.41653140
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40034595
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.38834130
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38389482
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34513015
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32693810
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29980543
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29759189
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.29100779
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.26065857
34CBP_20019798_ChIP-Seq_JUKART_Human2.21910461
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21910461
36ERG_20887958_ChIP-Seq_HPC-7_Mouse2.19191908
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14433889
38EZH2_22144423_ChIP-Seq_EOC_Human2.13021568
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.09163094
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06949809
41CIITA_25753668_ChIP-Seq_RAJI_Human2.03191171
42MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02835625
43VDR_23849224_ChIP-Seq_CD4+_Human2.02651803
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02093276
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.01763421
46* P300_19829295_ChIP-Seq_ESCs_Human2.00836253
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99569007
48VDR_21846776_ChIP-Seq_THP-1_Human1.98543122
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98455197
50GBX2_23144817_ChIP-Seq_PC3_Human1.98403178
51TAF15_26573619_Chip-Seq_HEK293_Human1.97981114
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.96591381
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95307270
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.94827764
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94031202
56SPI1_23547873_ChIP-Seq_NB4_Human1.92826251
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92596899
58FOXP3_21729870_ChIP-Seq_TREG_Human1.92098291
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87784449
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87732024
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87095280
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84496271
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82648117
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80923140
65MYC_22102868_ChIP-Seq_BL_Human1.79767097
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79410707
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77976157
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.76768575
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.75895010
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65865599
71XRN2_22483619_ChIP-Seq_HELA_Human1.65703194
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65679714
73AR_25329375_ChIP-Seq_VCAP_Human1.65179829
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64927381
75* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.63894225
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.62800870
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.62798547
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62428122
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.60825369
80VDR_24763502_ChIP-Seq_THP-1_Human1.59851047
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.58975317
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58180545
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56875853
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.56383880
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54844915
86MYC_19829295_ChIP-Seq_ESCs_Human1.54674536
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53439636
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52984676
89TAF2_19829295_ChIP-Seq_ESCs_Human1.52106204
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51419364
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51265923
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50888138
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.50576763
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50125445
95STAT3_23295773_ChIP-Seq_U87_Human1.48215686
96ERA_21632823_ChIP-Seq_H3396_Human1.48166176
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47598735
98MYB_26560356_Chip-Seq_TH2_Human1.46052444
99SOX2_19829295_ChIP-Seq_ESCs_Human1.45312565
100NANOG_19829295_ChIP-Seq_ESCs_Human1.45312565
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44277052
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43512148
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.42875431
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42733446
105SMAD4_21799915_ChIP-Seq_A2780_Human1.41587535
106* NANOG_20526341_ChIP-Seq_ESCs_Human1.41248808
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.41082391
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39050610
109RUNX2_22187159_ChIP-Seq_PCA_Human1.38900470
110TCF4_23295773_ChIP-Seq_U87_Human1.38696646
111ELK1_19687146_ChIP-ChIP_HELA_Human1.37988213
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37659743
113NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36923662
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36481115
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35611637
116MYB_26560356_Chip-Seq_TH1_Human1.35381473
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34947761
118DROSHA_22980978_ChIP-Seq_HELA_Human1.34322681
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34176650
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.33766960
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33136316
122TTF2_22483619_ChIP-Seq_HELA_Human1.31302601
123* FOXA1_25329375_ChIP-Seq_VCAP_Human1.30918249
124* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30918249
125E2F1_21310950_ChIP-Seq_MCF-7_Human1.30776164
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.30560780
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30484596
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.30179899
129TP53_18474530_ChIP-ChIP_U2OS_Human1.29847024
130CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29007843
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27971883
132* SMRT_27268052_Chip-Seq_Bcells_Human1.27959471
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25702819
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.24555001
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23531609
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.22736487
137ERG_20517297_ChIP-Seq_VCAP_Human1.22426615
138ETV1_20927104_ChIP-Seq_GIST48_Human1.22255729
139* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21005761
140MAF_26560356_Chip-Seq_TH1_Human1.20454869
141TCF4_22108803_ChIP-Seq_LS180_Human1.20298617
142GABP_19822575_ChIP-Seq_HepG2_Human1.20066583
143NCOR_22424771_ChIP-Seq_293T_Human1.18729840
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18715557
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18624576
146RAC3_21632823_ChIP-Seq_H3396_Human1.17194111
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16808213
148* CDX2_22108803_ChIP-Seq_LS180_Human1.16074445
149THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16062336
150GATA1_19941827_ChIP-Seq_MEL_Mouse1.16022563
151BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15881312
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15789422
153CBX2_27304074_Chip-Seq_ESCs_Mouse1.15572852
154HOXB7_26014856_ChIP-Seq_BT474_Human1.14911024
155RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14890944
156TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14869511
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14787897
158* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14715455
159RBPJ_21746931_ChIP-Seq_IB4_Human1.14510980
160EWS_26573619_Chip-Seq_HEK293_Human1.14104484
161MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13794623
162PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12459414
163TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12040651
164OCT1_27270436_Chip-Seq_PROSTATE_Human1.11882974
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11454103
166TCF7_22412390_ChIP-Seq_EML_Mouse1.11163634
167FLI1_21867929_ChIP-Seq_TH2_Mouse1.10073292
168CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09995327
169* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09975839
170TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09113834
171PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08407814
172PHF8_20622853_ChIP-Seq_HELA_Human1.08124023
173NFYB_21822215_ChIP-Seq_K562_Human1.08046908
174FOXM1_23109430_ChIP-Seq_U2OS_Human1.07508496
175OCT4_20526341_ChIP-Seq_ESCs_Human1.07504794
176SALL4_22934838_ChIP-ChIP_CD34+_Human1.07381348
177MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05765988
178UTX_26944678_Chip-Seq_JUKART_Human1.05752660
179HNFA_21074721_ChIP-Seq_CACO-2_Human1.05747860
180P53_21459846_ChIP-Seq_SAOS-2_Human1.05289959
181DCP1A_22483619_ChIP-Seq_HELA_Human1.05221146
182TBL1_22424771_ChIP-Seq_293T_Human1.05142117
183WDR5_24793694_ChIP-Seq_LNCAP_Human1.04857098
184FOXH1_21741376_ChIP-Seq_EPCs_Human1.04485161
185SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04420338
186CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04297909
187PIAS1_25552417_ChIP-Seq_VCAP_Human1.02791493
188MYC_18940864_ChIP-ChIP_HL60_Human1.02695467
189KDM2B_26808549_Chip-Seq_REH_Human1.02373412
190TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02272314
191ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01475923
192AR_21909140_ChIP-Seq_LNCAP_Human1.00115467
193MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99743355
194ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98565058
195RUNX_20019798_ChIP-Seq_JUKART_Human0.98298208
196* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96956207
197TFEB_21752829_ChIP-Seq_HELA_Human0.94555259
198CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93292935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.50097506
2MP0002396_abnormal_hematopoietic_system6.23761149
3MP0005377_hearing/vestibular/ear_phenot5.59602789
4MP0003878_abnormal_ear_physiology5.59602789
5MP0005397_hematopoietic_system_phenotyp3.98889203
6MP0001545_abnormal_hematopoietic_system3.98889203
7MP0002102_abnormal_ear_morphology3.59205798
8MP0003698_abnormal_male_reproductive3.41760550
9MP0004808_abnormal_hematopoietic_stem3.10387364
10MP0001835_abnormal_antigen_presentation3.08998527
11MP0005174_abnormal_tail_pigmentation3.02605348
12MP0001929_abnormal_gametogenesis2.94041908
13MP0005670_abnormal_white_adipose2.82587183
14MP0003646_muscle_fatigue2.77823468
15MP0001986_abnormal_taste_sensitivity2.74367398
16MP0005075_abnormal_melanosome_morpholog2.69851207
17MP0003724_increased_susceptibility_to2.66788172
18MP0004147_increased_porphyrin_level2.65846861
19MP0003011_delayed_dark_adaptation2.54965586
20MP0008007_abnormal_cellular_replicative2.46333365
21MP0009785_altered_susceptibility_to2.44595938
22MP0005409_darkened_coat_color2.32931305
23MP0003718_maternal_effect2.25218252
24MP0010094_abnormal_chromosome_stability2.23739107
25MP0006292_abnormal_olfactory_placode2.21413780
26MP0005464_abnormal_platelet_physiology2.16373157
27MP0006054_spinal_hemorrhage2.13330585
28MP0002095_abnormal_skin_pigmentation2.10292417
29MP0000685_abnormal_immune_system2.10019246
30MP0003763_abnormal_thymus_physiology2.05363833
31MP0002398_abnormal_bone_marrow2.04258128
32MP0009379_abnormal_foot_pigmentation2.02819763
33MP0002282_abnormal_trachea_morphology2.02798820
34MP0009278_abnormal_bone_marrow2.01383911
35MP0000490_abnormal_crypts_of2.00753322
36MP0001968_abnormal_touch/_nociception2.00625534
37MP0000465_gastrointestinal_hemorrhage1.99185535
38MP0002166_altered_tumor_susceptibility1.93063294
39MP0005025_abnormal_response_to1.92199631
40MP0005671_abnormal_response_to1.88739904
41MP0005423_abnormal_somatic_nervous1.87399304
42MP0008057_abnormal_DNA_replication1.84997081
43MP0005551_abnormal_eye_electrophysiolog1.82009525
44MP0001485_abnormal_pinna_reflex1.80549964
45MP0002161_abnormal_fertility/fecundity1.77359666
46MP0000678_abnormal_parathyroid_gland1.76970533
47MP0000689_abnormal_spleen_morphology1.70830023
48MP0001853_heart_inflammation1.70383988
49MP0002837_dystrophic_cardiac_calcinosis1.69838120
50MP0001486_abnormal_startle_reflex1.69612742
51MP0002420_abnormal_adaptive_immunity1.68458997
52MP0001819_abnormal_immune_cell1.63889460
53MP0002736_abnormal_nociception_after1.63851385
54MP0003111_abnormal_nucleus_morphology1.61941379
55MP0000716_abnormal_immune_system1.61517584
56MP0001188_hyperpigmentation1.60305024
57MP0002723_abnormal_immune_serum1.60286735
58MP0003693_abnormal_embryo_hatching1.60141282
59MP0005000_abnormal_immune_tolerance1.59307320
60MP0001800_abnormal_humoral_immune1.59027187
61MP0002429_abnormal_blood_cell1.58728264
62MP0002419_abnormal_innate_immunity1.58080116
63MP0002722_abnormal_immune_system1.57926647
64MP0008058_abnormal_DNA_repair1.57831671
65MP0005253_abnormal_eye_physiology1.56763314
66MP0003656_abnormal_erythrocyte_physiolo1.55611093
67MP0002938_white_spotting1.53101114
68MP0002249_abnormal_larynx_morphology1.52869427
69MP0002735_abnormal_chemical_nociception1.52363349
70MP0003077_abnormal_cell_cycle1.52197523
71MP0002210_abnormal_sex_determination1.51118636
72MP0009697_abnormal_copulation1.50918021
73MP0002452_abnormal_antigen_presenting1.50081644
74MP0002006_tumorigenesis1.48344102
75MP0002234_abnormal_pharynx_morphology1.45230046
76MP0002148_abnormal_hypersensitivity_rea1.42133722
77MP0003943_abnormal_hepatobiliary_system1.40671343
78MP0002019_abnormal_tumor_incidence1.36756820
79MP0001501_abnormal_sleep_pattern1.35823436
80MP0002405_respiratory_system_inflammati1.35354293
81MP0003186_abnormal_redox_activity1.35264829
82MP0000653_abnormal_sex_gland1.33347166
83MP0004859_abnormal_synaptic_plasticity1.33203879
84MP0001873_stomach_inflammation1.28899393
85MP0010155_abnormal_intestine_physiology1.26186199
86MP0001145_abnormal_male_reproductive1.25898532
87MP0002132_abnormal_respiratory_system1.25064954
88MP0000858_altered_metastatic_potential1.24009983
89MP0000427_abnormal_hair_cycle1.22778919
90MP0003436_decreased_susceptibility_to1.20811354
91MP0000703_abnormal_thymus_morphology1.20632405
92MP0002653_abnormal_ependyma_morphology1.18129338
93MP0009333_abnormal_splenocyte_physiolog1.16279098
94MP0002138_abnormal_hepatobiliary_system1.15379223
95MP0000049_abnormal_middle_ear1.11888101
96MP0002089_abnormal_postnatal_growth/wei1.11729364
97MP0003950_abnormal_plasma_membrane1.11645223
98MP0002822_catalepsy1.10688385
99MP0002160_abnormal_reproductive_system1.10399664
100MP0009053_abnormal_anal_canal1.10172978
101MP0000313_abnormal_cell_death1.09376811
102MP0009745_abnormal_behavioral_response1.08893224
103MP0000026_abnormal_inner_ear1.08353050
104MP0000681_abnormal_thyroid_gland1.07854296
105MP0001790_abnormal_immune_system1.07790000
106MP0005387_immune_system_phenotype1.07790000
107MP0008469_abnormal_protein_level1.06048629
108MP0000383_abnormal_hair_follicle1.03830790
109MP0006036_abnormal_mitochondrial_physio1.03754813
110MP0003880_abnormal_central_pattern1.02439444
111MP0003866_abnormal_defecation1.02245965
112MP0004957_abnormal_blastocyst_morpholog1.02208670
113MP0008872_abnormal_physiological_respon1.01382185
114MP0001764_abnormal_homeostasis0.99627418
115MP0000516_abnormal_urinary_system0.98272039
116MP0005367_renal/urinary_system_phenotyp0.98272039
117MP0001963_abnormal_hearing_physiology0.96949110
118MP0001984_abnormal_olfaction0.96823922
119MP0003283_abnormal_digestive_organ0.96374361
120MP0003786_premature_aging0.96033493
121MP0004145_abnormal_muscle_electrophysio0.95435816
122MP0000343_altered_response_to0.95420483
123MP0001765_abnormal_ion_homeostasis0.94370821
124MP0005084_abnormal_gallbladder_morpholo0.92116551
125MP0001845_abnormal_inflammatory_respons0.91213089
126MP0002272_abnormal_nervous_system0.90487921
127MP0004084_abnormal_cardiac_muscle0.90057078
128MP0000631_abnormal_neuroendocrine_gland0.89190393
129MP0002075_abnormal_coat/hair_pigmentati0.88220605
130MP0002067_abnormal_sensory_capabilities0.87920429
131MP0002229_neurodegeneration0.87731040
132MP0008569_lethality_at_weaning0.87127959
133MP0000015_abnormal_ear_pigmentation0.86674926
134MP0003567_abnormal_fetal_cardiomyocyte0.85677656
135MP0005408_hypopigmentation0.84479899
136MP0008877_abnormal_DNA_methylation0.83601557
137MP0002734_abnormal_mechanical_nocicepti0.82292158
138MP0004742_abnormal_vestibular_system0.81687472
139MP0009765_abnormal_xenobiotic_induced0.81208657
140MP0005395_other_phenotype0.80420261
141MP0005391_vision/eye_phenotype0.79887942
142MP0003119_abnormal_digestive_system0.79716812
143MP0003635_abnormal_synaptic_transmissio0.79510039
144MP0002127_abnormal_cardiovascular_syste0.78954381
145MP0005365_abnormal_bile_salt0.78621113
146MP0005220_abnormal_exocrine_pancreas0.77799660
147MP0000955_abnormal_spinal_cord0.76872316
148MP0004484_altered_response_of0.76379572
149MP0005389_reproductive_system_phenotype0.75578339
150MP0009763_increased_sensitivity_to0.74966342
151MP0005584_abnormal_enzyme/coenzyme_acti0.73850155
152MP0004133_heterotaxia0.73586973
153MP0000534_abnormal_ureter_morphology0.73160853
154MP0009046_muscle_twitch0.71399750
155MP0006072_abnormal_retinal_apoptosis0.70855300
156MP0002139_abnormal_hepatobiliary_system0.70098028
157MP0002932_abnormal_joint_morphology0.69550781
158MP0008961_abnormal_basal_metabolism0.69427417
159MP0005646_abnormal_pituitary_gland0.69315910
160MP0008775_abnormal_heart_ventricle0.68991886
161MP0001905_abnormal_dopamine_level0.68243331
162MP0003942_abnormal_urinary_system0.68128514
163* MP0002557_abnormal_social/conspecific_i0.67872918
164MP0001663_abnormal_digestive_system0.67265976
165MP0000467_abnormal_esophagus_morphology0.67260289
166MP0005167_abnormal_blood-brain_barrier0.67125758
167MP0001970_abnormal_pain_threshold0.66054829
168MP0002877_abnormal_melanocyte_morpholog0.65267570
169MP0000613_abnormal_salivary_gland0.63459514
170MP0002733_abnormal_thermal_nociception0.63156583
171MP0000598_abnormal_liver_morphology0.63095213
172MP0003221_abnormal_cardiomyocyte_apopto0.62366265
173MP0009764_decreased_sensitivity_to0.60925554
174MP0000477_abnormal_intestine_morphology0.60840137
175MP0001293_anophthalmia0.60568663
176MP0001119_abnormal_female_reproductive0.60315180
177MP0000372_irregular_coat_pigmentation0.60170592
178MP0002752_abnormal_somatic_nervous0.59653433
179MP0000470_abnormal_stomach_morphology0.59154348
180MP0000371_diluted_coat_color0.58875208
181MP0003075_altered_response_to0.57975107
182MP0004085_abnormal_heartbeat0.57970719
183MP0009384_cardiac_valve_regurgitation0.57965328
184MP0004142_abnormal_muscle_tone0.57721616
185MP0008873_increased_physiological_sensi0.56215025
186MP0008995_early_reproductive_senescence0.56076844
187MP0003806_abnormal_nucleotide_metabolis0.54812497
188MP0010307_abnormal_tumor_latency0.51377447
189MP0002928_abnormal_bile_duct0.51206770

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.14511828
2Aplastic anemia (HP:0001915)5.73526784
3Abnormal number of erythroid precursors (HP:0012131)5.61489097
4Thrombocytosis (HP:0001894)5.54654622
5Abnormality of cells of the erythroid lineage (HP:0012130)5.52427332
6Chronic otitis media (HP:0000389)5.37443153
7Reduced antithrombin III activity (HP:0001976)4.54766842
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.52795918
9Absent/shortened dynein arms (HP:0200106)4.52795918
10Reticulocytopenia (HP:0001896)4.50515131
11Petechiae (HP:0000967)4.34382726
12Attenuation of retinal blood vessels (HP:0007843)4.27695451
13Abnormal respiratory motile cilium physiology (HP:0012261)4.26562724
14Abnormal ciliary motility (HP:0012262)4.23769212
15Abnormality of the heme biosynthetic pathway (HP:0010472)4.17949307
16Abnormal rod and cone electroretinograms (HP:0008323)4.15153256
17Type I transferrin isoform profile (HP:0003642)4.14963007
18Nephronophthisis (HP:0000090)4.08082748
19Colon cancer (HP:0003003)3.86044018
20Acute lymphatic leukemia (HP:0006721)3.85872768
21Prolonged bleeding time (HP:0003010)3.85513665
22Poikiloderma (HP:0001029)3.72795719
23Tubulointerstitial nephritis (HP:0001970)3.65239569
24Abnormal respiratory epithelium morphology (HP:0012253)3.53242949
25Abnormal respiratory motile cilium morphology (HP:0005938)3.53242949
26IgM deficiency (HP:0002850)3.53195771
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.47137567
28Acute myeloid leukemia (HP:0004808)3.46034947
29Bony spicule pigmentary retinopathy (HP:0007737)3.42884202
30Pallor (HP:0000980)3.41892101
31Abnormality of the renal medulla (HP:0100957)3.38762425
32Abnormal glycosylation (HP:0012345)3.38072450
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.38072450
34Abnormal protein N-linked glycosylation (HP:0012347)3.38072450
35Abnormal protein glycosylation (HP:0012346)3.38072450
36Pancreatic fibrosis (HP:0100732)3.31729962
37Type II lissencephaly (HP:0007260)3.30682367
38Pancreatic cysts (HP:0001737)3.25705534
39Elevated erythrocyte sedimentation rate (HP:0003565)3.18253670
40Broad face (HP:0000283)3.16901181
41Abnormality of the columella (HP:0009929)3.04880432
42Entropion (HP:0000621)3.00855814
43Facial shape deformation (HP:0011334)2.94996906
44Potter facies (HP:0002009)2.94996906
45Infertility (HP:0000789)2.92951581
46Hypoplasia of the thymus (HP:0000778)2.91837002
47Congenital stationary night blindness (HP:0007642)2.90473466
48Abnormality of macular pigmentation (HP:0008002)2.84381549
49Retinal dysplasia (HP:0007973)2.82802206
50Macrocytic anemia (HP:0001972)2.81341694
51Abnormality of DNA repair (HP:0003254)2.80475173
52Progressive cerebellar ataxia (HP:0002073)2.77219348
53Abnormality of midbrain morphology (HP:0002418)2.76810777
54Molar tooth sign on MRI (HP:0002419)2.76810777
55Neoplasm of the oral cavity (HP:0100649)2.75082317
56Hyperkalemia (HP:0002153)2.74874681
57Epistaxis (HP:0000421)2.74643423
58Tubular atrophy (HP:0000092)2.74205506
59Muscle fiber atrophy (HP:0100295)2.73812151
60Bell-shaped thorax (HP:0001591)2.71839548
61Myelodysplasia (HP:0002863)2.71087300
62True hermaphroditism (HP:0010459)2.70908965
63Abnormality of the renal cortex (HP:0011035)2.67975279
64Agnosia (HP:0010524)2.63694849
65Myositis (HP:0100614)2.63580515
66Type 2 muscle fiber atrophy (HP:0003554)2.63283221
67Asymmetric septal hypertrophy (HP:0001670)2.61258003
68Hypoplastic ischia (HP:0003175)2.57476128
69Fatigable weakness (HP:0003473)2.54937752
70Abnormality of the neuromuscular junction (HP:0003398)2.54937752
71Panhypogammaglobulinemia (HP:0003139)2.52667829
72Recurrent viral infections (HP:0004429)2.50260751
73Stage 5 chronic kidney disease (HP:0003774)2.49879215
7411 pairs of ribs (HP:0000878)2.49492286
75Renal Fanconi syndrome (HP:0001994)2.48989153
76Sclerocornea (HP:0000647)2.48627229
77Cystic liver disease (HP:0006706)2.46150783
78Pancytopenia (HP:0001876)2.45594010
79Pendular nystagmus (HP:0012043)2.45417896
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44208710
81Recurrent bronchitis (HP:0002837)2.43734929
82Abnormality of the fingertips (HP:0001211)2.42304751
83Amaurosis fugax (HP:0100576)2.41924834
84Abnormality of the prostate (HP:0008775)2.40140748
85Abnormal drinking behavior (HP:0030082)2.39737397
86Polydipsia (HP:0001959)2.39737397
87Rhinitis (HP:0012384)2.39194317
88Decreased central vision (HP:0007663)2.37704537
89Occipital encephalocele (HP:0002085)2.36351569
90Amelogenesis imperfecta (HP:0000705)2.33320076
91Recurrent abscess formation (HP:0002722)2.31752833
92Cerebellar dysplasia (HP:0007033)2.31547125
933-Methylglutaconic aciduria (HP:0003535)2.31208833
94Basal cell carcinoma (HP:0002671)2.27179660
95Abnormality of the parietal bone (HP:0002696)2.25874289
96Enlarged epiphyses (HP:0010580)2.22560804
97Chronic bronchitis (HP:0004469)2.20913643
98Intellectual disability, moderate (HP:0002342)2.20195921
99Congenital hepatic fibrosis (HP:0002612)2.18211725
100Abnormality of T cell physiology (HP:0011840)2.17664701
101Broad palm (HP:0001169)2.16500625
102Impaired platelet aggregation (HP:0003540)2.15871245
103Abnormal platelet function (HP:0011869)2.15871245
104Cone-rod dystrophy (HP:0000548)2.15747249
105Nasal polyposis (HP:0100582)2.15449008
106Cutaneous melanoma (HP:0012056)2.14853994
107Abnormal urine output (HP:0012590)2.14009113
108Optic nerve hypoplasia (HP:0000609)2.13387772
109Abnormality of urine glucose concentration (HP:0011016)2.12148038
110Glycosuria (HP:0003076)2.12148038
111Chromsome breakage (HP:0040012)2.11427414
112Male infertility (HP:0003251)2.08647088
113Microretrognathia (HP:0000308)2.08523261
114Abnormality of the ischium (HP:0003174)2.08522105
115Recurrent bacterial skin infections (HP:0005406)2.08486464
116Renal cortical cysts (HP:0000803)2.07433937
117Patchy hypopigmentation of hair (HP:0011365)2.06812844
118Medulloblastoma (HP:0002885)2.06172069
119Adrenal hypoplasia (HP:0000835)2.04901488
120Neoplasm of head and neck (HP:0012288)2.04725878
121Esophageal neoplasm (HP:0100751)2.04725878
122Neutropenia (HP:0001875)2.04457100
123Lymphoma (HP:0002665)2.04216172
124Tubulointerstitial abnormality (HP:0001969)2.03617441
125Abnormal biliary tract physiology (HP:0012439)2.02521602
126Bile duct proliferation (HP:0001408)2.02521602
127Oral leukoplakia (HP:0002745)2.02255696
128Keratoconus (HP:0000563)2.02005847
129Increased corneal curvature (HP:0100692)2.02005847
130Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01662696
131Encephalitis (HP:0002383)2.00863511
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00537506
133White forelock (HP:0002211)1.99362264
134Azoospermia (HP:0000027)1.98900881
135Polyuria (HP:0000103)1.98159484
136Recurrent fungal infections (HP:0002841)1.98017180
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97443181
138Agammaglobulinemia (HP:0004432)1.96719806
139Anophthalmia (HP:0000528)1.95484274
140Neoplasm of the tracheobronchial system (HP:0100552)1.94321868
141Abnormality of dental color (HP:0011073)1.93840285
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93568484
143IgG deficiency (HP:0004315)1.93391113
144Alveolar cell carcinoma (HP:0006519)1.91849671
145Exertional dyspnea (HP:0002875)1.90774435
146Abnormality of the nasal mucosa (HP:0000433)1.90698922
147Bronchiectasis (HP:0002110)1.90132103
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89652311
149Abnormality of the pubic bones (HP:0003172)1.88708792
150Squamous cell carcinoma (HP:0002860)1.88690677
151Hepatic necrosis (HP:0002605)1.87613563
152Hypoplasia of the uterus (HP:0000013)1.86084804
153Respiratory difficulties (HP:0002880)1.85493555
154Abnormality of the costochondral junction (HP:0000919)1.85449830
155Severe visual impairment (HP:0001141)1.84642785
156Depressed nasal tip (HP:0000437)1.84446050
157Premature graying of hair (HP:0002216)1.83447447
158Impulsivity (HP:0100710)1.83033085
159Generalized aminoaciduria (HP:0002909)1.83011720
160Abnormality of renal excretion (HP:0011036)1.82241971
161Bone marrow hypocellularity (HP:0005528)1.81499301
162Gingival bleeding (HP:0000225)1.81471665
163Increased intramyocellular lipid droplets (HP:0012240)1.80916849
164Chorioretinal atrophy (HP:0000533)1.80095898
165Bulbous nose (HP:0000414)1.79560209
166Bilateral microphthalmos (HP:0007633)1.78105016
167Abnormal delayed hypersensitivity skin test (HP:0002963)1.77689516
168Abnormality of the nasal septum (HP:0000419)1.76784571
169Cellulitis (HP:0100658)1.76584536
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76343588
171Increased hepatocellular lipid droplets (HP:0006565)1.74575085
172Medial flaring of the eyebrow (HP:0010747)1.73877461
173Abnormality of reticulocytes (HP:0004312)1.73590588
174Median cleft lip (HP:0000161)1.73062838
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.72717015
176Progressive muscle weakness (HP:0003323)1.69760314
177Increased muscle lipid content (HP:0009058)1.69533543
178Cheilitis (HP:0100825)1.69331158
179Thyroid-stimulating hormone excess (HP:0002925)1.69231600
180Osteomalacia (HP:0002749)1.69123776
181Facial cleft (HP:0002006)1.68817013
182Hypothermia (HP:0002045)1.68799433
183Bicornuate uterus (HP:0000813)1.68670340
184Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68541245
185Blepharitis (HP:0000498)1.68540017
186Synostosis of carpal bones (HP:0005048)1.68166821
187Abnormal spermatogenesis (HP:0008669)1.67532922
188Horizontal nystagmus (HP:0000666)1.67460696
189Genetic anticipation (HP:0003743)1.67231127
190Postaxial foot polydactyly (HP:0001830)1.67044585
191Unilateral renal agenesis (HP:0000122)1.66351579
192Photophobia (HP:0000613)1.65654929
193Lipid accumulation in hepatocytes (HP:0006561)1.65261783
194Asplenia (HP:0001746)1.64842059
195Gastrointestinal inflammation (HP:0004386)1.64053446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.96551739
2KIT4.21410073
3STK163.84707162
4PLK23.82741734
5MAP4K23.63757800
6FLT33.53123069
7LATS13.01908505
8INSRR2.99558463
9FRK2.89362626
10TNIK2.84493261
11NUAK12.80447294
12PIM22.74638202
13STK38L2.63011722
14EEF2K2.56415931
15NME22.55466641
16DDR22.54531079
17TEC2.51749581
18WEE12.48646773
19TGFBR12.30896178
20BTK2.30724141
21TESK12.21484940
22STK382.20860205
23MATK2.19602158
24FER2.18461544
25VRK12.17244518
26PNCK2.04063874
27CDK192.00105964
28ZAK2.00003567
29ACVR1B1.98117177
30CSF1R1.97147492
31BRD41.95517022
32MAPKAPK51.89669234
33STK241.86388393
34MAP4K11.83955380
35MAP3K121.83531259
36PINK11.79979262
37DYRK31.77943711
38RPS6KB21.76722580
39AKT31.75189461
40TAOK31.71400458
41PIK3CG1.67276452
42PASK1.66309966
43BRSK21.47675688
44MAP3K41.41705423
45GRK11.34193605
46MAPKAPK31.33330970
47MAPK151.32696032
48MAP2K31.32662250
49SIK31.31652879
50MAP3K61.28712175
51MUSK1.27778954
52MKNK11.27631174
53CDK71.25840563
54TSSK61.25144562
55BCKDK1.22865572
56TBK11.17230453
57CLK11.16388246
58PTK2B1.11679731
59SYK1.09786495
60CCNB11.08062763
61IRAK41.07980423
62TAOK21.04453199
63JAK31.04075063
64WNK41.03777038
65PBK1.02319707
66ATR0.99494504
67MAP2K70.93085598
68LRRK20.92217715
69PDK10.91836410
70CDK80.90342944
71MST40.90104253
72FES0.89877950
73PRKCE0.89814059
74PIM10.89590093
75CDC70.87169234
76PDPK10.85069849
77CASK0.84359144
78ZAP700.83921514
79MAP2K60.83208967
80LYN0.82798195
81PAK30.81011577
82IKBKB0.78460812
83DAPK10.78180930
84NEK60.78023632
85TIE10.74446161
86EIF2AK30.74086745
87WNK10.73475741
88CDK40.73138374
89TNK20.72431546
90CSNK1G20.72088846
91CAMK1G0.71681848
92PRKG10.71266746
93TRPM70.70385698
94WNK30.70259270
95NEK20.69921125
96CAMK10.69793083
97BUB10.67597213
98MKNK20.67069726
99PRKCG0.65931658
100LCK0.65913282
101RPS6KA40.64964147
102RAF10.64240382
103SCYL20.63583491
104MST1R0.62608229
105PRKG20.62083441
106MAPK40.61419844
107MYLK0.61385637
108EPHA40.60657080
109ADRBK20.60226176
110TYRO30.60019432
111MET0.59969008
112ITK0.59468208
113IKBKE0.58107277
114CSNK1G10.57912137
115MAP3K70.57905666
116DYRK1B0.57792560
117STK40.57629533
118TRIM280.57380700
119NTRK30.56841889
120STK30.56608565
121CSNK1G30.55533132
122SRPK10.54462258
123KDR0.54179029
124NLK0.54065847
125EIF2AK10.53790409
126MARK10.52379748
127RPS6KA60.48839689
128PKN20.45701958
129MAPK110.45386293
130SGK20.45146525
131TXK0.45112103
132TYK20.44820336
133MAPK130.44497391
134PRKCI0.44352205
135RPS6KL10.44209578
136RPS6KC10.44209578
137HIPK20.43944546
138HCK0.43821036
139AURKB0.43436539
140TLK10.42709100
141PLK30.42564069
142PRKD30.42164977
143RPS6KB10.41985704
144SGK4940.40583071
145SGK2230.40583071
146BMPR1B0.40238459
147PAK40.39335752
148CHUK0.38756902
149CSNK2A20.37719688
150PRKCQ0.37703461
151MAP3K90.37476433
152PRKAA20.36880095
153BRSK10.36347313
154CAMK2A0.36243754
155DYRK1A0.35994857
156PRKACA0.35309864
157RPS6KA10.35138651
158PLK10.35098731
159MAPK30.35038363
160CAMK40.34943349
161ILK0.34827303
162ERBB30.34662852
163MAP3K140.34358978
164DYRK20.33511004
165OXSR10.32052109
166FGFR10.30117339
167STK390.28708893
168ADRBK10.28247073
169PRKAA10.27642315
170GSK3B0.26147625
171RPS6KA20.25322979
172MAPK80.24920233
173CSNK1A10.24826657
174GRK50.24373505

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.14357067
2DNA replication_Homo sapiens_hsa030305.13890955
3Ribosome_Homo sapiens_hsa030104.93962401
4Mismatch repair_Homo sapiens_hsa034304.15138973
5Fatty acid biosynthesis_Homo sapiens_hsa000613.92148375
6Olfactory transduction_Homo sapiens_hsa047403.64537228
7Phototransduction_Homo sapiens_hsa047443.16606154
8Base excision repair_Homo sapiens_hsa034103.05660451
9Homologous recombination_Homo sapiens_hsa034402.89773346
10Nucleotide excision repair_Homo sapiens_hsa034202.66437101
11RNA polymerase_Homo sapiens_hsa030202.62487893
12Pyrimidine metabolism_Homo sapiens_hsa002402.41217932
13Taste transduction_Homo sapiens_hsa047422.39682704
14Spliceosome_Homo sapiens_hsa030402.38420621
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26540332
16Butanoate metabolism_Homo sapiens_hsa006502.03275549
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90625105
18Fanconi anemia pathway_Homo sapiens_hsa034601.88527943
19Folate biosynthesis_Homo sapiens_hsa007901.87505796
20Dorso-ventral axis formation_Homo sapiens_hsa043201.80385440
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80033193
22Non-homologous end-joining_Homo sapiens_hsa034501.76980834
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.73878621
24Proteasome_Homo sapiens_hsa030501.67942614
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65154506
26Cell cycle_Homo sapiens_hsa041101.64752908
27Pentose phosphate pathway_Homo sapiens_hsa000301.64006847
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62011263
29Primary immunodeficiency_Homo sapiens_hsa053401.58429952
30Nicotine addiction_Homo sapiens_hsa050331.57903975
31Herpes simplex infection_Homo sapiens_hsa051681.55539315
32Nitrogen metabolism_Homo sapiens_hsa009101.52562672
33RNA degradation_Homo sapiens_hsa030181.52361648
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46807568
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46064275
36Retinol metabolism_Homo sapiens_hsa008301.45287010
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44376125
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.42535667
39Linoleic acid metabolism_Homo sapiens_hsa005911.40088643
40Protein export_Homo sapiens_hsa030601.38878937
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37840786
42Antigen processing and presentation_Homo sapiens_hsa046121.32587437
43Sulfur relay system_Homo sapiens_hsa041221.32281075
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.31982523
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30224193
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29478447
47RNA transport_Homo sapiens_hsa030131.28566668
48Salivary secretion_Homo sapiens_hsa049701.28137384
49Hedgehog signaling pathway_Homo sapiens_hsa043401.27755966
50Other glycan degradation_Homo sapiens_hsa005111.27074272
51Hematopoietic cell lineage_Homo sapiens_hsa046401.25716947
52Purine metabolism_Homo sapiens_hsa002301.25559011
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23392066
54N-Glycan biosynthesis_Homo sapiens_hsa005101.22384988
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21916568
56Circadian entrainment_Homo sapiens_hsa047131.21780548
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20013255
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19332038
59One carbon pool by folate_Homo sapiens_hsa006701.18299090
60Insulin secretion_Homo sapiens_hsa049111.13338251
61Legionellosis_Homo sapiens_hsa051341.12341163
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12047985
63Chemical carcinogenesis_Homo sapiens_hsa052041.11981266
64Measles_Homo sapiens_hsa051621.11834674
65Fat digestion and absorption_Homo sapiens_hsa049751.11613818
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.11133737
67Leishmaniasis_Homo sapiens_hsa051401.09839683
68Cardiac muscle contraction_Homo sapiens_hsa042601.06244883
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02517821
70Fatty acid degradation_Homo sapiens_hsa000711.01370605
71Glycerolipid metabolism_Homo sapiens_hsa005611.00910743
72Morphine addiction_Homo sapiens_hsa050320.98900247
73B cell receptor signaling pathway_Homo sapiens_hsa046620.98100868
74Calcium signaling pathway_Homo sapiens_hsa040200.97355655
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94411782
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93308331
77Gastric acid secretion_Homo sapiens_hsa049710.92782836
78Serotonergic synapse_Homo sapiens_hsa047260.92009046
79Caffeine metabolism_Homo sapiens_hsa002320.91357577
80Synaptic vesicle cycle_Homo sapiens_hsa047210.91212806
81Oocyte meiosis_Homo sapiens_hsa041140.90394673
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89352557
83Thyroid cancer_Homo sapiens_hsa052160.87814365
84Acute myeloid leukemia_Homo sapiens_hsa052210.87588129
85Amphetamine addiction_Homo sapiens_hsa050310.86479639
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84474647
87Fatty acid metabolism_Homo sapiens_hsa012120.83956007
88Ether lipid metabolism_Homo sapiens_hsa005650.82366685
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.80611714
90Propanoate metabolism_Homo sapiens_hsa006400.80597582
91Basal transcription factors_Homo sapiens_hsa030220.80497196
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.79847451
93p53 signaling pathway_Homo sapiens_hsa041150.79393251
94Graft-versus-host disease_Homo sapiens_hsa053320.78462846
95Platelet activation_Homo sapiens_hsa046110.78220342
96Tryptophan metabolism_Homo sapiens_hsa003800.78207206
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77518639
98Renin secretion_Homo sapiens_hsa049240.76648354
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74434056
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74305503
101Allograft rejection_Homo sapiens_hsa053300.73541493
102cAMP signaling pathway_Homo sapiens_hsa040240.73349635
103Glutamatergic synapse_Homo sapiens_hsa047240.73152433
104Galactose metabolism_Homo sapiens_hsa000520.72626808
105Epstein-Barr virus infection_Homo sapiens_hsa051690.70521333
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70307595
107Pertussis_Homo sapiens_hsa051330.70159359
108Type II diabetes mellitus_Homo sapiens_hsa049300.70044260
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.69495198
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.69449544
111Regulation of autophagy_Homo sapiens_hsa041400.67787768
112GABAergic synapse_Homo sapiens_hsa047270.66844252
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.66469171
114Influenza A_Homo sapiens_hsa051640.66365576
115Hepatitis B_Homo sapiens_hsa051610.65678504
116Systemic lupus erythematosus_Homo sapiens_hsa053220.65088299
117Huntingtons disease_Homo sapiens_hsa050160.64004275
118Autoimmune thyroid disease_Homo sapiens_hsa053200.63994641
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63910670
120African trypanosomiasis_Homo sapiens_hsa051430.63367335
121Type I diabetes mellitus_Homo sapiens_hsa049400.63113779
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61659022
123Long-term depression_Homo sapiens_hsa047300.61256983
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60478562
125Shigellosis_Homo sapiens_hsa051310.60314736
126Viral carcinogenesis_Homo sapiens_hsa052030.59162590
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57899210
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57808515
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.57759782
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.56822642
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55486994
132Histidine metabolism_Homo sapiens_hsa003400.55142982
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52838921
134Pancreatic secretion_Homo sapiens_hsa049720.52040803
135Dopaminergic synapse_Homo sapiens_hsa047280.51708500
136Oxytocin signaling pathway_Homo sapiens_hsa049210.48457387
137Tyrosine metabolism_Homo sapiens_hsa003500.47907497
138Arginine and proline metabolism_Homo sapiens_hsa003300.47066457
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46898569
140Protein digestion and absorption_Homo sapiens_hsa049740.46559290
141Oxidative phosphorylation_Homo sapiens_hsa001900.46277896
142Cocaine addiction_Homo sapiens_hsa050300.45856074
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45528153
144Biosynthesis of amino acids_Homo sapiens_hsa012300.44595067
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43680402
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42811389
147Chronic myeloid leukemia_Homo sapiens_hsa052200.42752229
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42364683
149ABC transporters_Homo sapiens_hsa020100.40616952
150Toxoplasmosis_Homo sapiens_hsa051450.40065234
151Cholinergic synapse_Homo sapiens_hsa047250.39513167
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39325807
153Peroxisome_Homo sapiens_hsa041460.37537672
154Apoptosis_Homo sapiens_hsa042100.36537256
155Long-term potentiation_Homo sapiens_hsa047200.36305940
156Malaria_Homo sapiens_hsa051440.36037367
157mRNA surveillance pathway_Homo sapiens_hsa030150.35478315
158Asthma_Homo sapiens_hsa053100.34073551
159Osteoclast differentiation_Homo sapiens_hsa043800.32779829
160Small cell lung cancer_Homo sapiens_hsa052220.32422552
161Glutathione metabolism_Homo sapiens_hsa004800.32169526
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32009585
163HTLV-I infection_Homo sapiens_hsa051660.30050133
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27889834
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23491379
166Metabolic pathways_Homo sapiens_hsa011000.21824974
167Selenocompound metabolism_Homo sapiens_hsa004500.19590905
168Alcoholism_Homo sapiens_hsa050340.18538980
169Fatty acid elongation_Homo sapiens_hsa000620.18440966
170Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18135863
171Carbon metabolism_Homo sapiens_hsa012000.17910834
172Non-small cell lung cancer_Homo sapiens_hsa052230.16446885

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