MBLAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)9.76235686
2positive regulation of amino acid transport (GO:0051957)6.90022429
3negative regulation of amino acid transport (GO:0051956)6.00179601
4positive regulation of catecholamine secretion (GO:0033605)5.93586213
5neuron cell-cell adhesion (GO:0007158)5.64186718
6ribosome assembly (GO:0042255)5.32099721
7presynaptic membrane assembly (GO:0097105)5.25122448
8neuronal action potential propagation (GO:0019227)4.97259748
9postsynaptic membrane organization (GO:0001941)4.77749699
10DNA replication checkpoint (GO:0000076)4.69794179
11protein localization to synapse (GO:0035418)4.69733554
12formation of translation preinitiation complex (GO:0001731)4.63423719
13serotonin receptor signaling pathway (GO:0007210)4.62394839
14presynaptic membrane organization (GO:0097090)4.61144852
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60836289
16vocalization behavior (GO:0071625)4.58661237
17nuclear pore complex assembly (GO:0051292)4.47552854
18phospholipid scrambling (GO:0017121)4.46706785
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.42910560
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.38931212
21synaptic vesicle exocytosis (GO:0016079)4.37635943
22nuclear pore organization (GO:0006999)4.37239128
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22845175
24glutamate receptor signaling pathway (GO:0007215)4.15705345
25negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.06656300
26regulation of glutamate receptor signaling pathway (GO:1900449)4.00350850
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94201737
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91721944
29cullin deneddylation (GO:0010388)3.89504128
30regulation of synaptic vesicle exocytosis (GO:2000300)3.89346877
31pyrimidine nucleotide catabolic process (GO:0006244)3.86438229
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.82584931
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.79863591
34synaptic transmission, glutamatergic (GO:0035249)3.78665919
35branched-chain amino acid catabolic process (GO:0009083)3.74562910
36neurotransmitter-gated ion channel clustering (GO:0072578)3.73884911
37neuron-neuron synaptic transmission (GO:0007270)3.73794342
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69458113
39neuron recognition (GO:0008038)3.59106878
40transmission of nerve impulse (GO:0019226)3.55910556
41glutamate secretion (GO:0014047)3.52956770
42regulation of synaptic vesicle transport (GO:1902803)3.49318718
43pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.45394806
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42648356
45exploration behavior (GO:0035640)3.41782370
46righting reflex (GO:0060013)3.40818689
47DNA unwinding involved in DNA replication (GO:0006268)3.40296939
48protein deneddylation (GO:0000338)3.36810961
49neurotransmitter secretion (GO:0007269)3.36396498
50startle response (GO:0001964)3.34738937
51synaptic vesicle maturation (GO:0016188)3.33204366
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.33028181
53negative regulation of sister chromatid segregation (GO:0033046)3.33028181
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33028181
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33028181
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33028181
57regulation of dopamine secretion (GO:0014059)3.32691693
58negative regulation of neurotransmitter transport (GO:0051589)3.30114532
59positive regulation of synapse assembly (GO:0051965)3.29168451
60histone H4-K8 acetylation (GO:0043982)3.28521429
61histone H4-K5 acetylation (GO:0043981)3.28521429
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28508161
63gamma-aminobutyric acid transport (GO:0015812)3.27629920
64negative regulation of chromosome segregation (GO:0051985)3.26875387
65chaperone-mediated protein transport (GO:0072321)3.25006428
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24795478
67regulation of mitotic sister chromatid segregation (GO:0033047)3.23424475
68regulation of sister chromatid segregation (GO:0033045)3.23424475
69regulation of mitotic sister chromatid separation (GO:0010965)3.23424475
70mitotic spindle assembly checkpoint (GO:0007094)3.23421891
71pore complex assembly (GO:0046931)3.22420029
72response to histamine (GO:0034776)3.22344509
73positive regulation of RNA splicing (GO:0033120)3.21996971
74long-chain fatty acid biosynthetic process (GO:0042759)3.20430093
75positive regulation of membrane potential (GO:0045838)3.18817469
76regulation of translational fidelity (GO:0006450)3.18054615
77spindle assembly checkpoint (GO:0071173)3.17352525
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15754871
79regulation of vesicle fusion (GO:0031338)3.14774106
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13369386
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13369386
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11567262
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10229072
84neurotransmitter transport (GO:0006836)3.10042595
85regulation of postsynaptic membrane potential (GO:0060078)3.10026596
86synapse assembly (GO:0007416)3.09945775
87mitotic spindle checkpoint (GO:0071174)3.09392816
88locomotory exploration behavior (GO:0035641)3.08681655
89regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.05356563
90protein localization to cilium (GO:0061512)3.05276481
91regulation of histone H3-K9 methylation (GO:0051570)3.03297186
92regulation of respiratory system process (GO:0044065)3.02750076
93spindle checkpoint (GO:0031577)3.02522266
94N-glycan processing (GO:0006491)3.01346842
95pteridine-containing compound biosynthetic process (GO:0042559)3.01269960
96meiotic chromosome segregation (GO:0045132)3.01057628
97regulation of neuronal synaptic plasticity (GO:0048168)3.00598935
98base-excision repair, AP site formation (GO:0006285)3.00429796
99neuromuscular process controlling posture (GO:0050884)3.00300478
100positive regulation of dendritic spine development (GO:0060999)2.98597125
101neurotransmitter uptake (GO:0001504)2.97667287
102branched-chain amino acid metabolic process (GO:0009081)2.97073398
103regulation of amino acid transport (GO:0051955)2.95544236
104mitotic chromosome condensation (GO:0007076)2.94616668
105peptidyl-arginine N-methylation (GO:0035246)2.94549008
106peptidyl-arginine methylation (GO:0018216)2.94549008
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.93714117
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92902523
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.92902523
110positive regulation of granulocyte differentiation (GO:0030854)2.90832101
111negative regulation of amine transport (GO:0051953)2.90198176
112microtubule nucleation (GO:0007020)2.90085599
113mechanosensory behavior (GO:0007638)2.89911671
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89269980
115long-term memory (GO:0007616)2.89212484
116auditory behavior (GO:0031223)2.89186723
117negative regulation of organic acid transport (GO:0032891)2.87816867
118sister chromatid segregation (GO:0000819)2.87472803
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87040688
120regulation of synapse assembly (GO:0051963)2.86964030
121IMP biosynthetic process (GO:0006188)2.86405384
122pharyngeal system development (GO:0060037)2.86109539
123regulation of protein kinase A signaling (GO:0010738)2.84895693
124regulation of translational elongation (GO:0006448)2.84719398
125positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84412894
126regulation of neurotransmitter levels (GO:0001505)2.84042942
127axonal fasciculation (GO:0007413)2.82799156
128dendritic spine morphogenesis (GO:0060997)2.82494045
129positive regulation of neurotransmitter secretion (GO:0001956)2.82083926
130regulation of glutamate secretion (GO:0014048)2.81991426
131mitotic sister chromatid segregation (GO:0000070)2.81217814
132DNA topological change (GO:0006265)2.80154102
133adult walking behavior (GO:0007628)2.79825982
134protein localization to chromosome, centromeric region (GO:0071459)2.78268604
135dendrite development (GO:0016358)2.77680466
136piRNA metabolic process (GO:0034587)2.77608414
137learning (GO:0007612)2.76639161
138regulation of Rac protein signal transduction (GO:0035020)2.75070941
139termination of RNA polymerase II transcription (GO:0006369)2.75006940
140long-term synaptic potentiation (GO:0060291)2.74430462
141membrane depolarization (GO:0051899)2.74009093
142intestinal epithelial cell development (GO:0060576)2.73502278
143regulation of axon regeneration (GO:0048679)2.73365398
144regulation of neuron projection regeneration (GO:0070570)2.73365398
145regulation of pigment cell differentiation (GO:0050932)2.73165429
146negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72445364
147glucocorticoid receptor signaling pathway (GO:0042921)2.72263915
148regulation of neurotransmitter secretion (GO:0046928)2.72260035
149folic acid-containing compound biosynthetic process (GO:0009396)2.71860978
150calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71859202
151positive regulation of amine transport (GO:0051954)2.70093809
152regulation of synaptic transmission, GABAergic (GO:0032228)2.69540813
153membrane assembly (GO:0071709)2.69315074
154pyrimidine nucleobase catabolic process (GO:0006208)2.68650356
155regulation of chromosome segregation (GO:0051983)2.67383657
156mannose metabolic process (GO:0006013)2.66809721
157attachment of spindle microtubules to kinetochore (GO:0008608)2.66706997
158mRNA export from nucleus (GO:0006406)2.66163837
159establishment of synaptic vesicle localization (GO:0097480)2.65360260
160synaptic vesicle transport (GO:0048489)2.65360260
161cerebellar granule cell differentiation (GO:0021707)2.65316620
162behavioral fear response (GO:0001662)2.64675776
163behavioral defense response (GO:0002209)2.64675776
164regulation of respiratory gaseous exchange (GO:0043576)2.64124341
165protein K11-linked ubiquitination (GO:0070979)2.61826515
166RNA export from nucleus (GO:0006405)2.61454158
167layer formation in cerebral cortex (GO:0021819)2.61087970
168establishment of integrated proviral latency (GO:0075713)2.60975075
169synaptic transmission (GO:0007268)2.60956051
170dopamine transport (GO:0015872)2.60307101
171central nervous system myelination (GO:0022010)2.60291152
172axon ensheathment in central nervous system (GO:0032291)2.60291152
173positive regulation of mitotic sister chromatid separation (GO:1901970)2.59661539
174positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59661539
175positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59661539
176rRNA methylation (GO:0031167)2.59173225
177central nervous system projection neuron axonogenesis (GO:0021952)2.59132735
178cytoplasmic mRNA processing body assembly (GO:0033962)2.59028205
179IMP metabolic process (GO:0046040)2.58982940
180mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58916993
181mitotic nuclear envelope disassembly (GO:0007077)2.57567452
182fatty acid elongation (GO:0030497)2.57533784
183intraspecies interaction between organisms (GO:0051703)2.57487819
184social behavior (GO:0035176)2.57487819
185DNA methylation involved in gamete generation (GO:0043046)2.57403107
186regulation of dendritic spine development (GO:0060998)2.57054669
187CENP-A containing nucleosome assembly (GO:0034080)2.56751246
188regulation of neurotransmitter transport (GO:0051588)2.56467093
189positive regulation of dendritic spine morphogenesis (GO:0061003)2.55810738
190regulation of Golgi to plasma membrane protein transport (GO:0042996)2.52910843
191base-excision repair (GO:0006284)2.51918013
192nucleobase biosynthetic process (GO:0046112)2.51886443
193protein localization to kinetochore (GO:0034501)2.51697195
194negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.51484084
195regulation of translational initiation (GO:0006446)2.50919685
196purine nucleobase biosynthetic process (GO:0009113)2.48201642
197peptidyl-arginine omega-N-methylation (GO:0035247)2.47204951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14417862
2EZH2_22144423_ChIP-Seq_EOC_Human6.64334386
3GBX2_23144817_ChIP-Seq_PC3_Human4.35244954
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41273385
5AR_21909140_ChIP-Seq_LNCAP_Human3.27977397
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.26221122
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17802027
8TAF15_26573619_Chip-Seq_HEK293_Human3.16440504
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09162713
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08370843
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse3.03887822
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95446570
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86240520
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73500403
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66728720
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51362869
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49555776
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46244819
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45592722
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41067169
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36921677
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35942478
23REST_21632747_ChIP-Seq_MESCs_Mouse2.32256093
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.31797220
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30460109
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30460109
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.25360068
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24280476
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.22581632
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21336899
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19913487
32ELK1_19687146_ChIP-ChIP_HELA_Human2.19160816
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18463759
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15901766
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15675028
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13863016
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13355140
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13267609
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12216016
40CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10361920
41E2F1_21310950_ChIP-Seq_MCF-7_Human2.09503387
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06853951
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06392417
44ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06132860
45IGF1R_20145208_ChIP-Seq_DFB_Human2.02598658
46SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02205176
47EZH2_27294783_Chip-Seq_ESCs_Mouse2.02141390
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01324188
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99336560
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.96939143
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94030641
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93333118
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90596693
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90582571
55P300_19829295_ChIP-Seq_ESCs_Human1.89273652
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88939810
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88127222
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87318977
59AR_21572438_ChIP-Seq_LNCaP_Human1.87267791
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82633362
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81454881
62DCP1A_22483619_ChIP-Seq_HELA_Human1.81287465
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80588291
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80417622
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80025987
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.79317674
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.79183350
68FUS_26573619_Chip-Seq_HEK293_Human1.78265573
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.77425585
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76100678
71VDR_23849224_ChIP-Seq_CD4+_Human1.73510046
72TTF2_22483619_ChIP-Seq_HELA_Human1.70484091
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69395137
74SMAD4_21799915_ChIP-Seq_A2780_Human1.69381450
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69313908
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.68767186
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65923629
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65890006
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64733847
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62798687
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.59398254
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57211106
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56485451
84RNF2_27304074_Chip-Seq_NSC_Mouse1.55967325
85ZNF274_21170338_ChIP-Seq_K562_Hela1.54915718
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51683024
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.50592295
88VDR_22108803_ChIP-Seq_LS180_Human1.50078277
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49686097
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48739486
91DROSHA_22980978_ChIP-Seq_HELA_Human1.47909380
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45131327
93XRN2_22483619_ChIP-Seq_HELA_Human1.44869702
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43867361
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43125037
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.42361163
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.42281459
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.42204690
99ER_23166858_ChIP-Seq_MCF-7_Human1.41653536
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40656871
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39751459
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37932856
103CIITA_25753668_ChIP-Seq_RAJI_Human1.36778663
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.35274042
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35223103
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.33744665
107AR_25329375_ChIP-Seq_VCAP_Human1.32362260
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31674695
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31599758
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26290513
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23028463
112GABP_19822575_ChIP-Seq_HepG2_Human1.22710516
113CHD1_26751641_Chip-Seq_LNCaP_Human1.21665005
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.21532843
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20815433
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20651271
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20281379
118KDM5A_27292631_Chip-Seq_BREAST_Human1.19324775
119MYC_18940864_ChIP-ChIP_HL60_Human1.19205511
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19137811
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18523548
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18380853
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18006646
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16387848
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15740197
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.15549776
127FLI1_27457419_Chip-Seq_LIVER_Mouse1.14122604
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13883760
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13669188
130RUNX2_22187159_ChIP-Seq_PCA_Human1.12643228
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.12533205
132SMAD_19615063_ChIP-ChIP_OVARY_Human1.12434393
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11856080
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11568810
135ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10758194
136PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09402255
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.09374841
138STAT3_23295773_ChIP-Seq_U87_Human1.08051115
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06376151
140JUN_21703547_ChIP-Seq_K562_Human1.06322089
141P53_22387025_ChIP-Seq_ESCs_Mouse1.06145407
142SOX2_21211035_ChIP-Seq_LN229_Gbm1.04209965
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.03652110
144KDM2B_26808549_Chip-Seq_REH_Human1.02852955
145E2F1_18555785_Chip-Seq_ESCs_Mouse1.02813357
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02512260
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02288755
148EWS_26573619_Chip-Seq_HEK293_Human1.02107759
149* TAL1_26923725_Chip-Seq_HPCs_Mouse1.02063134
150SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01439350
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01000013
152TCF4_23295773_ChIP-Seq_U87_Human1.00939799
153RING1B_27294783_Chip-Seq_ESCs_Mouse0.99071462
154GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98985255
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98912079
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98912079
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97166392
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96170170
159* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95883334
160EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95269214
161* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94537171
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93725621
163P300_18555785_Chip-Seq_ESCs_Mouse0.93718346
164NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93198405
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93195384
166SOX9_26525672_Chip-Seq_HEART_Mouse0.91692540
167FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91141820
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.90607582
169ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90300958
170P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89494178
171RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89100382
172BCAT_22108803_ChIP-Seq_LS180_Human0.88960974
173TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88803345
174SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87780085
175SRF_21415370_ChIP-Seq_HL-1_Mouse0.87755694
176NANOG_21062744_ChIP-ChIP_HESCs_Human0.87503815
177NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87376902
178HTT_18923047_ChIP-ChIP_STHdh_Human0.86960371
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84648887
180SOX17_20123909_ChIP-Seq_XEN_Mouse0.84428685
181TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81062623
182FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77336182
183REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77300306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.22743197
2MP0002396_abnormal_hematopoietic_system4.56901530
3MP0004859_abnormal_synaptic_plasticity4.16151521
4MP0008057_abnormal_DNA_replication3.84327581
5MP0008961_abnormal_basal_metabolism3.68233333
6MP0003635_abnormal_synaptic_transmissio3.43945988
7MP0004270_analgesia3.35885916
8MP0001968_abnormal_touch/_nociception3.28850291
9MP0010094_abnormal_chromosome_stability3.20435147
10MP0009745_abnormal_behavioral_response3.06977968
11MP0008058_abnormal_DNA_repair2.99397013
12MP0008877_abnormal_DNA_methylation2.86733160
13MP0006276_abnormal_autonomic_nervous2.83158272
14MP0002064_seizures2.77639550
15MP0009046_muscle_twitch2.69300980
16MP0002736_abnormal_nociception_after2.69235270
17MP0002272_abnormal_nervous_system2.68383520
18MP0002735_abnormal_chemical_nociception2.67281024
19MP0002234_abnormal_pharynx_morphology2.65985230
20MP0002063_abnormal_learning/memory/cond2.65595316
21MP0003693_abnormal_embryo_hatching2.65144612
22MP0004957_abnormal_blastocyst_morpholog2.64463054
23MP0002572_abnormal_emotion/affect_behav2.56408039
24MP0003656_abnormal_erythrocyte_physiolo2.55288466
25MP0002734_abnormal_mechanical_nocicepti2.54914491
26MP0005423_abnormal_somatic_nervous2.54193765
27MP0001188_hyperpigmentation2.46536482
28MP0001486_abnormal_startle_reflex2.42880143
29MP0003111_abnormal_nucleus_morphology2.41536462
30MP0002733_abnormal_thermal_nociception2.30980485
31MP0001529_abnormal_vocalization2.29150637
32MP0009697_abnormal_copulation2.21827163
33MP0003077_abnormal_cell_cycle2.21652307
34MP0001501_abnormal_sleep_pattern2.17172326
35MP0002009_preneoplasia2.15957526
36MP0002067_abnormal_sensory_capabilities2.15450880
37MP0001970_abnormal_pain_threshold2.08318494
38MP0001905_abnormal_dopamine_level2.04506116
39MP0004808_abnormal_hematopoietic_stem2.03645168
40MP0001440_abnormal_grooming_behavior2.03286450
41MP0004142_abnormal_muscle_tone2.02965119
42MP0009379_abnormal_foot_pigmentation1.96954802
43MP0002184_abnormal_innervation1.86759209
44MP0001984_abnormal_olfaction1.85730053
45MP0008932_abnormal_embryonic_tissue1.85231095
46MP0000778_abnormal_nervous_system1.82729747
47MP0005645_abnormal_hypothalamus_physiol1.79578811
48MP0003329_amyloid_beta_deposits1.77096536
49MP0002557_abnormal_social/conspecific_i1.73227128
50MP0004924_abnormal_behavior1.72450738
51MP0005386_behavior/neurological_phenoty1.72450738
52MP0005409_darkened_coat_color1.71481160
53MP0001986_abnormal_taste_sensitivity1.70512924
54MP0003786_premature_aging1.67920817
55MP0002822_catalepsy1.61753986
56MP0003121_genomic_imprinting1.55985335
57MP0003136_yellow_coat_color1.53558287
58MP0006292_abnormal_olfactory_placode1.52459222
59MP0008569_lethality_at_weaning1.50124156
60MP0008007_abnormal_cellular_replicative1.50105458
61MP0002638_abnormal_pupillary_reflex1.49958358
62MP0000569_abnormal_digit_pigmentation1.49496546
63MP0010234_abnormal_vibrissa_follicle1.47214364
64MP0005646_abnormal_pituitary_gland1.45151114
65MP0000350_abnormal_cell_proliferation1.42588680
66MP0002876_abnormal_thyroid_physiology1.42585653
67MP0001730_embryonic_growth_arrest1.41958817
68MP0004782_abnormal_surfactant_physiolog1.35362682
69MP0000955_abnormal_spinal_cord1.33945476
70MP0001502_abnormal_circadian_rhythm1.33537996
71MP0003879_abnormal_hair_cell1.33225475
72MP0000013_abnormal_adipose_tissue1.32801820
73MP0000920_abnormal_myelination1.31316192
74MP0002882_abnormal_neuron_morphology1.30416813
75MP0003123_paternal_imprinting1.29836527
76MP0002066_abnormal_motor_capabilities/c1.26102360
77MP0004742_abnormal_vestibular_system1.25853757
78MP0003868_abnormal_feces_composition1.25188537
79MP0004811_abnormal_neuron_physiology1.21648193
80MP0000678_abnormal_parathyroid_gland1.18680501
81MP0005220_abnormal_exocrine_pancreas1.17864783
82MP0010386_abnormal_urinary_bladder1.16569857
83MP0010352_gastrointestinal_tract_polyps1.15732117
84MP0005551_abnormal_eye_electrophysiolog1.15670187
85MP0002229_neurodegeneration1.13503121
86MP0000372_irregular_coat_pigmentation1.13028768
87MP0001697_abnormal_embryo_size1.12901393
88MP0001672_abnormal_embryogenesis/_devel1.10604464
89MP0005380_embryogenesis_phenotype1.10604464
90MP0002160_abnormal_reproductive_system1.08739137
91MP0000631_abnormal_neuroendocrine_gland1.06994261
92MP0002909_abnormal_adrenal_gland1.06856599
93MP0004145_abnormal_muscle_electrophysio1.06706453
94MP0010307_abnormal_tumor_latency1.05984001
95MP0004381_abnormal_hair_follicle1.03035060
96MP0000358_abnormal_cell_content/1.02389505
97MP0003633_abnormal_nervous_system1.01527315
98MP0004885_abnormal_endolymph0.99407550
99MP0004197_abnormal_fetal_growth/weight/0.98563630
100MP0003718_maternal_effect0.98263788
101MP0003122_maternal_imprinting0.98237297
102MP0000015_abnormal_ear_pigmentation0.98153800
103MP0003984_embryonic_growth_retardation0.97809948
104MP0001963_abnormal_hearing_physiology0.97627127
105MP0002084_abnormal_developmental_patter0.95788754
106MP0003787_abnormal_imprinting0.94567367
107MP0002752_abnormal_somatic_nervous0.94002977
108MP0000003_abnormal_adipose_tissue0.93653221
109MP0002088_abnormal_embryonic_growth/wei0.93626409
110MP0005174_abnormal_tail_pigmentation0.93208616
111MP0002080_prenatal_lethality0.91506626
112MP0003631_nervous_system_phenotype0.91358411
113MP0005535_abnormal_body_temperature0.89672730
114MP0006036_abnormal_mitochondrial_physio0.89039769
115MP0005379_endocrine/exocrine_gland_phen0.88208769
116MP0004233_abnormal_muscle_weight0.88037739
117MP0002152_abnormal_brain_morphology0.86003427
118MP0001664_abnormal_digestion0.84033669
119MP0002086_abnormal_extraembryonic_tissu0.83196113
120MP0009780_abnormal_chondrocyte_physiolo0.82890881
121MP0005075_abnormal_melanosome_morpholog0.81315777
122MP0002177_abnormal_outer_ear0.81197052
123MP0002249_abnormal_larynx_morphology0.80759204
124MP0000613_abnormal_salivary_gland0.80689177
125MP0004134_abnormal_chest_morphology0.80045313
126MP0003634_abnormal_glial_cell0.79761780
127MP0004215_abnormal_myocardial_fiber0.79726339
128MP0000313_abnormal_cell_death0.78407201
129MP0008874_decreased_physiological_sensi0.78002922
130MP0004147_increased_porphyrin_level0.77671598
131MP0005171_absent_coat_pigmentation0.77526658
132MP0009703_decreased_birth_body0.77386239
133MP0002069_abnormal_eating/drinking_beha0.76399964
134MP0006072_abnormal_retinal_apoptosis0.74718603
135MP0002102_abnormal_ear_morphology0.74461960
136MP0001177_atelectasis0.74450851
137MP0002210_abnormal_sex_determination0.74384135
138MP0002085_abnormal_embryonic_tissue0.73303210
139MP0003115_abnormal_respiratory_system0.72939974
140MP0000026_abnormal_inner_ear0.72673139
141MP0003935_abnormal_craniofacial_develop0.72307440
142MP0000604_amyloidosis0.72068791
143MP0005384_cellular_phenotype0.71691583
144MP0008872_abnormal_physiological_respon0.70559350
145MP0004858_abnormal_nervous_system0.69505491
146MP0002751_abnormal_autonomic_nervous0.68398053
147MP0003632_abnormal_nervous_system0.68024841
148MP0000049_abnormal_middle_ear0.67758629
149MP0000681_abnormal_thyroid_gland0.67296991
150MP0001929_abnormal_gametogenesis0.67192685
151MP0003119_abnormal_digestive_system0.65959753
152MP0003890_abnormal_embryonic-extraembry0.65536994
153MP0006035_abnormal_mitochondrial_morpho0.64161381
154MP0001485_abnormal_pinna_reflex0.63891835
155MP0000751_myopathy0.63159174
156MP0001191_abnormal_skin_condition0.61058303
157MP0008995_early_reproductive_senescence0.61004958
158MP0001145_abnormal_male_reproductive0.60208824
159MP0002090_abnormal_vision0.59327791
160MP0003221_abnormal_cardiomyocyte_apopto0.58873627
161MP0003698_abnormal_male_reproductive0.58702681
162MP0000653_abnormal_sex_gland0.58437588
163MP0005499_abnormal_olfactory_system0.58252506
164MP0005394_taste/olfaction_phenotype0.58252506
165MP0005621_abnormal_cell_physiology0.58096343
166MP0002837_dystrophic_cardiac_calcinosis0.57677962
167MP0002095_abnormal_skin_pigmentation0.57627108
168MP0001348_abnormal_lacrimal_gland0.57562769
169MP0002163_abnormal_gland_morphology0.56415199
170MP0003938_abnormal_ear_development0.53960358
171MP0003690_abnormal_glial_cell0.52885412

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.87021557
2Focal seizures (HP:0007359)4.47906696
3Abnormality of the intrinsic pathway (HP:0010989)4.30779058
4Myokymia (HP:0002411)4.27909548
5Atonic seizures (HP:0010819)4.16621440
6Hypothermia (HP:0002045)4.14365444
7Visual hallucinations (HP:0002367)4.10376369
8Epileptic encephalopathy (HP:0200134)4.09848669
9Febrile seizures (HP:0002373)4.01623856
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.54424100
11Short 1st metacarpal (HP:0010034)3.54424100
12Hyperventilation (HP:0002883)3.54278035
13Absence seizures (HP:0002121)3.40883035
14Dialeptic seizures (HP:0011146)3.39230667
15Progressive cerebellar ataxia (HP:0002073)3.38208771
16Acute necrotizing encephalopathy (HP:0006965)3.24763570
17Papillary thyroid carcinoma (HP:0002895)3.21697825
18Broad-based gait (HP:0002136)3.21503783
19Progressive inability to walk (HP:0002505)3.20068378
20Limb dystonia (HP:0002451)3.19957923
21Abnormality of the renal collecting system (HP:0004742)3.05412121
22Abnormality of the 1st metacarpal (HP:0010009)3.04313197
23Retinal dysplasia (HP:0007973)3.01974777
24Generalized tonic-clonic seizures (HP:0002069)2.96287212
25Mitochondrial inheritance (HP:0001427)2.95288028
26Gaze-evoked nystagmus (HP:0000640)2.94749833
27Abnormal mitochondria in muscle tissue (HP:0008316)2.93117766
28Neurofibrillary tangles (HP:0002185)2.89327344
29Progressive macrocephaly (HP:0004481)2.88488076
30Shoulder girdle muscle weakness (HP:0003547)2.86781018
31Supranuclear gaze palsy (HP:0000605)2.80769958
32Abnormality of homocysteine metabolism (HP:0010919)2.78560200
33Homocystinuria (HP:0002156)2.78560200
34Chromsome breakage (HP:0040012)2.77075419
35Cerebral edema (HP:0002181)2.76177523
36Polyphagia (HP:0002591)2.75390861
37Menstrual irregularities (HP:0000858)2.73925530
38Mutism (HP:0002300)2.72129881
39Hepatocellular necrosis (HP:0001404)2.71266652
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68568142
41Inability to walk (HP:0002540)2.62974810
42Ketosis (HP:0001946)2.62755767
43Increased hepatocellular lipid droplets (HP:0006565)2.59690006
44Methylmalonic acidemia (HP:0002912)2.59408865
45Abnormality of the corticospinal tract (HP:0002492)2.59210794
46Urinary urgency (HP:0000012)2.59054365
47Gait imbalance (HP:0002141)2.56442843
48Embryonal renal neoplasm (HP:0011794)2.55141845
49Nephroblastoma (Wilms tumor) (HP:0002667)2.52861425
50Acute lymphatic leukemia (HP:0006721)2.52089264
51Scanning speech (HP:0002168)2.51863167
52Thyroid carcinoma (HP:0002890)2.51557128
53Acute encephalopathy (HP:0006846)2.51484035
54Agitation (HP:0000713)2.51401023
55Truncal ataxia (HP:0002078)2.48581505
56Short phalanx of the thumb (HP:0009660)2.48276054
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.47693136
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47693136
59Renal Fanconi syndrome (HP:0001994)2.47198507
60Abnormality of the common coagulation pathway (HP:0010990)2.45857471
61Esotropia (HP:0000565)2.44931154
62Abnormality of methionine metabolism (HP:0010901)2.44692693
63Lip pit (HP:0100267)2.43532431
64Medulloblastoma (HP:0002885)2.42452810
65Anxiety (HP:0000739)2.41200554
66Broad alveolar ridges (HP:0000187)2.38974177
67Increased CSF lactate (HP:0002490)2.37625067
68Drooling (HP:0002307)2.37145442
69Excessive salivation (HP:0003781)2.37145442
70Microvesicular hepatic steatosis (HP:0001414)2.35638004
71Acute myeloid leukemia (HP:0004808)2.35084496
72Poor suck (HP:0002033)2.34087129
73Abnormal eating behavior (HP:0100738)2.33762434
74Neuroendocrine neoplasm (HP:0100634)2.33350835
75Action tremor (HP:0002345)2.32692121
76Acanthocytosis (HP:0001927)2.31474580
77Nonprogressive disorder (HP:0003680)2.31006685
78Optic disc pallor (HP:0000543)2.30654088
79Pheochromocytoma (HP:0002666)2.28631194
80Type II lissencephaly (HP:0007260)2.28178416
81Cerebral inclusion bodies (HP:0100314)2.27739165
82Dysmetria (HP:0001310)2.25712000
83Medial flaring of the eyebrow (HP:0010747)2.24402878
84Pelvic girdle muscle weakness (HP:0003749)2.24257189
85Vertebral arch anomaly (HP:0008438)2.21729328
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.19744495
87Absent/shortened dynein arms (HP:0200106)2.19744495
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19562261
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18786463
90Stenosis of the external auditory canal (HP:0000402)2.18451617
91Abnormality of cochlea (HP:0000375)2.17103615
92Lipid accumulation in hepatocytes (HP:0006561)2.15229388
93Hemiparesis (HP:0001269)2.14335396
94Abnormal ciliary motility (HP:0012262)2.14247095
95Akinesia (HP:0002304)2.12761139
96Capillary hemangiomas (HP:0005306)2.12292485
97Amblyopia (HP:0000646)2.12282130
98Ankle clonus (HP:0011448)2.12236297
99Impaired proprioception (HP:0010831)2.11783982
100Megaloblastic anemia (HP:0001889)2.11498595
101Spastic paraplegia (HP:0001258)2.11083029
102Psychosis (HP:0000709)2.10654093
103Gonadotropin excess (HP:0000837)2.10588426
104Parakeratosis (HP:0001036)2.10317400
105Congenital primary aphakia (HP:0007707)2.09868425
106Nephrogenic diabetes insipidus (HP:0009806)2.09338903
107Poor eye contact (HP:0000817)2.09261576
108Abnormality of the axillary hair (HP:0100134)2.09091311
109Abnormality of secondary sexual hair (HP:0009888)2.09091311
110Generalized myoclonic seizures (HP:0002123)2.08240554
111Lower limb muscle weakness (HP:0007340)2.06931428
112Abnormal hair whorl (HP:0010721)2.06745949
113Impaired vibration sensation in the lower limbs (HP:0002166)2.06510950
114Abnormality of glycolysis (HP:0004366)2.06469301
115Protruding tongue (HP:0010808)2.05438387
116Insidious onset (HP:0003587)2.04487126
117Termporal pattern (HP:0011008)2.04487126
118Premature ovarian failure (HP:0008209)2.04079132
119Sensory axonal neuropathy (HP:0003390)2.02353801
120Absent speech (HP:0001344)2.02204132
1213-Methylglutaconic aciduria (HP:0003535)2.01892847
122Amyotrophic lateral sclerosis (HP:0007354)1.99973897
123Blue irides (HP:0000635)1.99969901
124Epileptiform EEG discharges (HP:0011182)1.99218906
125Abnormal respiratory motile cilium morphology (HP:0005938)1.98726590
126Abnormal respiratory epithelium morphology (HP:0012253)1.98726590
127Volvulus (HP:0002580)1.98344818
128Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96612972
129Menorrhagia (HP:0000132)1.95330478
130Paraplegia (HP:0010550)1.95045314
131Dysdiadochokinesis (HP:0002075)1.94990823
132Cerebral hypomyelination (HP:0006808)1.93728908
133Peripheral hypomyelination (HP:0007182)1.93644410
134Papilledema (HP:0001085)1.92906109
135Brushfield spots (HP:0001088)1.92579200
136Fair hair (HP:0002286)1.92550643
137Lissencephaly (HP:0001339)1.91748368
138Abnormality of the hip-girdle musculature (HP:0001445)1.91450540
139Abnormality of the musculature of the pelvis (HP:0001469)1.91450540
140Depression (HP:0000716)1.90815751
141Respiratory difficulties (HP:0002880)1.90789129
142Increased intramyocellular lipid droplets (HP:0012240)1.90644568
143Thyroid-stimulating hormone excess (HP:0002925)1.89538343
144Delusions (HP:0000746)1.87952756
145Hepatic necrosis (HP:0002605)1.87572556
146Genital tract atresia (HP:0001827)1.87148283
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.86099130
148Asymmetry of the thorax (HP:0001555)1.85912235
149Abnormality of binocular vision (HP:0011514)1.84614202
150Diplopia (HP:0000651)1.84614202
151EEG with generalized epileptiform discharges (HP:0011198)1.84262767
152Vaginal atresia (HP:0000148)1.84172729
153Spastic gait (HP:0002064)1.83049236
154Fetal akinesia sequence (HP:0001989)1.81663613
155Type I transferrin isoform profile (HP:0003642)1.80262928
156Urinary bladder sphincter dysfunction (HP:0002839)1.80200170
157Exercise-induced muscle cramps (HP:0003710)1.80159080
158Embryonal neoplasm (HP:0002898)1.79273812
159Microglossia (HP:0000171)1.78765702
160Horizontal nystagmus (HP:0000666)1.77509330
161Myelodysplasia (HP:0002863)1.76903740
162Resting tremor (HP:0002322)1.74374551
163Dysmetric saccades (HP:0000641)1.72679320
164Increased muscle lipid content (HP:0009058)1.71972941
165Increased nuchal translucency (HP:0010880)1.70773002
166Abnormality of the vitamin B12 metabolism (HP:0004341)1.70516282
167Morphological abnormality of the inner ear (HP:0011390)1.69572926
168Dyskinesia (HP:0100660)1.68893181
169Choreoathetosis (HP:0001266)1.68035450
170Progressive external ophthalmoplegia (HP:0000590)1.66774811
171Fatigue (HP:0012378)1.66693247
172Rimmed vacuoles (HP:0003805)1.66191446
173Glioma (HP:0009733)1.64699058
174Ependymoma (HP:0002888)1.64147631
175Impaired vibratory sensation (HP:0002495)1.62629139
176Abnormality of serum amino acid levels (HP:0003112)1.61882791
177Duplicated collecting system (HP:0000081)1.61160871
178Abnormality of chromosome stability (HP:0003220)1.61136928
179Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.60185951
180Autoamputation (HP:0001218)1.58650702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.81298069
2CASK4.58343764
3TNIK4.15224328
4SCYL23.79978946
5NTRK33.76894254
6MAP3K123.50356891
7MAP2K73.17261764
8MARK12.99089460
9BUB12.57377256
10RPS6KA42.56603830
11MUSK2.54805628
12EPHA42.53374531
13CDK192.36895647
14EIF2AK12.19790439
15TRIM282.16330025
16MAP3K42.12265585
17BCKDK10.4335046
18SRPK11.99868590
19MINK11.99158338
20MAPK131.83766045
21CDC71.83492120
22RIPK41.82755174
23EIF2AK21.75225712
24MAP3K91.74678275
25MAP2K41.67479878
26ERBB31.57738195
27NTRK21.55779258
28NTRK11.49495862
29PNCK1.48839767
30ICK1.47911841
31CAMKK21.47132279
32FES1.46105622
33GRK51.42709970
34OXSR11.37309240
35GRK71.36205394
36MAP3K101.36052197
37TSSK61.35936994
38NEK11.33459088
39TTK1.31996047
40PHKG11.31469656
41PHKG21.31469656
42STK391.30844530
43NUAK11.28685624
44BRD41.25541032
45STK161.24959840
46CSNK1G21.23586210
47TAF11.23106934
48ADRBK21.21310163
49CAMK2A1.16866251
50UHMK11.12265989
51ARAF1.12233042
52MAPKAPK51.11107525
53CAMK2B1.09059789
54CDK51.08957067
55CSNK1G31.06441270
56PLK21.04420257
57BMPR21.01977303
58CAMK11.00362890
59CDK121.00094785
60DAPK20.98727347
61PASK0.97261734
62TNK20.97092825
63KSR20.94614907
64DAPK10.93038799
65DYRK20.92684846
66MAP4K20.91161885
67BMPR1B0.89688215
68PRKCG0.88698776
69ATR0.88495836
70MAP3K130.87175818
71KSR10.85371903
72PKN20.84589703
73MKNK10.83907663
74PRPF4B0.83891416
75FLT30.83474401
76MAP3K60.82078748
77MAP3K10.80031641
78CDK80.79419483
79MKNK20.78455739
80CSNK1G10.78230005
81SIK20.74152398
82PBK0.74074527
83NME10.73769138
84SGK4940.73646103
85SGK2230.73646103
86STK40.73048237
87CAMK2D0.71470061
88FGR0.71445459
89DYRK1A0.71095204
90PRKCE0.71081979
91CDK70.69974712
92PKN10.69374743
93LATS20.69184609
94PAK60.68781085
95PLK30.67434977
96RAF10.65248721
97RPS6KB10.61501728
98YES10.61235827
99IRAK20.60802335
100ATM0.59849674
101CAMKK10.58642243
102CDK140.57106006
103RPS6KB20.56884191
104CDK60.56849580
105AURKB0.55510419
106CAMK2G0.55401637
107SYK0.55350557
108MAP3K20.54941182
109WNK30.54852710
110MARK20.54827283
111CSNK1A1L0.54496581
112STK110.54319647
113CHEK10.52471800
114PLK10.52451572
115CDK180.50328665
116NEK90.49936352
117BCR0.49894653
118WNK40.48663408
119PLK40.48201963
120CDK30.47187465
121EEF2K0.47180860
122CDK11A0.46806298
123CDK150.46628844
124MAP2K60.46328403
125AURKA0.45945159
126SIK30.45581454
127CCNB10.45407159
128MAPK120.45140431
129SGK20.44491768
130ALK0.44482890
131AKT30.44088279
132ADRBK10.43453404
133IRAK10.43220874
134VRK10.42901297
135AKT20.42882043
136CDK20.42413151
137PRKACA0.42410833
138NEK60.40819164
139PIM20.39607353
140SGK10.39103771
141BRAF0.38092726
142PRKD30.37728905
143INSRR0.37196221
144PRKG10.36107932
145PAK30.34880251
146PRKDC0.34767674
147MAPK40.34054587
148KIT0.33806513
149FYN0.33699664
150MAPK150.32798633
151PRKCZ0.32795980
152BLK0.32769712
153CDK10.30846972
154CHEK20.28256657
155FGFR10.27684654
156PINK10.26313514
157RPS6KA50.25792587
158FGFR30.25447744
159FRK0.25314729
160WEE10.24954119
161LATS10.24196467
162RET0.22188346
163DYRK30.21958282
164ZAK0.20520020

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.29683158
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95253498
3Synaptic vesicle cycle_Homo sapiens_hsa047212.86632944
4Oxidative phosphorylation_Homo sapiens_hsa001902.83044282
5Mismatch repair_Homo sapiens_hsa034302.78044987
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77856950
7GABAergic synapse_Homo sapiens_hsa047272.70275624
8Glutamatergic synapse_Homo sapiens_hsa047242.52116778
9Propanoate metabolism_Homo sapiens_hsa006402.48477417
10Morphine addiction_Homo sapiens_hsa050322.47875339
11DNA replication_Homo sapiens_hsa030302.40281736
12Circadian entrainment_Homo sapiens_hsa047132.36351351
13Serotonergic synapse_Homo sapiens_hsa047262.33644970
14Base excision repair_Homo sapiens_hsa034102.26362710
15Cell cycle_Homo sapiens_hsa041102.24389413
16Taste transduction_Homo sapiens_hsa047422.22019074
17Olfactory transduction_Homo sapiens_hsa047402.19249961
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14910991
19Parkinsons disease_Homo sapiens_hsa050122.14530123
20Long-term potentiation_Homo sapiens_hsa047202.12772278
21Alzheimers disease_Homo sapiens_hsa050102.10089434
22Nucleotide excision repair_Homo sapiens_hsa034202.08195231
23Amphetamine addiction_Homo sapiens_hsa050312.07819006
24Collecting duct acid secretion_Homo sapiens_hsa049662.05380162
25Spliceosome_Homo sapiens_hsa030402.03381720
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00812517
27Dopaminergic synapse_Homo sapiens_hsa047281.99403202
28RNA degradation_Homo sapiens_hsa030181.88667294
29Salivary secretion_Homo sapiens_hsa049701.85075243
30Long-term depression_Homo sapiens_hsa047301.83877024
31One carbon pool by folate_Homo sapiens_hsa006701.83461155
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82074585
33RNA transport_Homo sapiens_hsa030131.80407577
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69822204
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68174344
36Folate biosynthesis_Homo sapiens_hsa007901.67082045
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65103837
38Cholinergic synapse_Homo sapiens_hsa047251.61590364
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58851696
40Insulin secretion_Homo sapiens_hsa049111.57600708
41Non-homologous end-joining_Homo sapiens_hsa034501.55669416
42Calcium signaling pathway_Homo sapiens_hsa040201.54545643
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54355964
44mRNA surveillance pathway_Homo sapiens_hsa030151.54128216
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52145797
46Basal transcription factors_Homo sapiens_hsa030221.50105138
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48009973
48Renin secretion_Homo sapiens_hsa049241.47630414
49Cocaine addiction_Homo sapiens_hsa050301.47400753
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45930611
51Huntingtons disease_Homo sapiens_hsa050161.42385976
52Cardiac muscle contraction_Homo sapiens_hsa042601.41596695
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37200658
54Gastric acid secretion_Homo sapiens_hsa049711.32296952
55Phototransduction_Homo sapiens_hsa047441.30711377
56Vibrio cholerae infection_Homo sapiens_hsa051101.30342523
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29493019
58Biosynthesis of amino acids_Homo sapiens_hsa012301.24902660
59Thyroid cancer_Homo sapiens_hsa052161.24779103
60Protein export_Homo sapiens_hsa030601.24750187
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21874979
62Fatty acid elongation_Homo sapiens_hsa000621.19367936
63Vitamin B6 metabolism_Homo sapiens_hsa007501.19153152
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18148543
65Oxytocin signaling pathway_Homo sapiens_hsa049211.16418210
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13032253
67Fanconi anemia pathway_Homo sapiens_hsa034601.12000523
68SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11301799
69GnRH signaling pathway_Homo sapiens_hsa049121.06535669
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.05436041
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03727309
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02570446
73Axon guidance_Homo sapiens_hsa043601.01864377
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00046051
75Gap junction_Homo sapiens_hsa045400.98952802
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98389071
77mTOR signaling pathway_Homo sapiens_hsa041500.98138393
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96950903
79cAMP signaling pathway_Homo sapiens_hsa040240.95461036
80Carbon metabolism_Homo sapiens_hsa012000.90147913
81Dorso-ventral axis formation_Homo sapiens_hsa043200.88806191
82Starch and sucrose metabolism_Homo sapiens_hsa005000.86725415
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86512648
84Colorectal cancer_Homo sapiens_hsa052100.83678617
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83381828
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81325758
87Purine metabolism_Homo sapiens_hsa002300.80852538
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80652171
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79545599
90Pyrimidine metabolism_Homo sapiens_hsa002400.76933364
91RNA polymerase_Homo sapiens_hsa030200.76560566
92Ether lipid metabolism_Homo sapiens_hsa005650.75008573
93Pyruvate metabolism_Homo sapiens_hsa006200.74354814
94Pancreatic cancer_Homo sapiens_hsa052120.73021608
95Melanogenesis_Homo sapiens_hsa049160.72649695
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.69535447
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69328656
98Pancreatic secretion_Homo sapiens_hsa049720.67934375
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67830710
100Sphingolipid metabolism_Homo sapiens_hsa006000.67076491
101Homologous recombination_Homo sapiens_hsa034400.66843211
102Chronic myeloid leukemia_Homo sapiens_hsa052200.66221800
103Rheumatoid arthritis_Homo sapiens_hsa053230.66208373
104Pentose phosphate pathway_Homo sapiens_hsa000300.65684292
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65334518
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64916829
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64909955
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63282373
109ErbB signaling pathway_Homo sapiens_hsa040120.61676161
110Endometrial cancer_Homo sapiens_hsa052130.61659098
111AMPK signaling pathway_Homo sapiens_hsa041520.61392290
112Non-small cell lung cancer_Homo sapiens_hsa052230.60707779
113Fatty acid metabolism_Homo sapiens_hsa012120.60210846
114Steroid biosynthesis_Homo sapiens_hsa001000.59144068
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.57299882
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57038520
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56791699
118Butanoate metabolism_Homo sapiens_hsa006500.55439523
119Type I diabetes mellitus_Homo sapiens_hsa049400.54791883
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.54182859
121Melanoma_Homo sapiens_hsa052180.53354008
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53316812
123Estrogen signaling pathway_Homo sapiens_hsa049150.52836110
124Alcoholism_Homo sapiens_hsa050340.52496094
125TGF-beta signaling pathway_Homo sapiens_hsa043500.52066309
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52034297
127Ras signaling pathway_Homo sapiens_hsa040140.50522930
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49903732
129African trypanosomiasis_Homo sapiens_hsa051430.49824520
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.49268724
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47801094
132Renin-angiotensin system_Homo sapiens_hsa046140.47777795
133p53 signaling pathway_Homo sapiens_hsa041150.47758602
134Glucagon signaling pathway_Homo sapiens_hsa049220.46073127
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45826463
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44320988
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44109495
138Ovarian steroidogenesis_Homo sapiens_hsa049130.43331636
139MAPK signaling pathway_Homo sapiens_hsa040100.41661119
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40943275
141Thyroid hormone synthesis_Homo sapiens_hsa049180.40916920
142Choline metabolism in cancer_Homo sapiens_hsa052310.39775199
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.38741538
144Phagosome_Homo sapiens_hsa041450.37964431
145Viral carcinogenesis_Homo sapiens_hsa052030.37786916
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37543899
147Ribosome_Homo sapiens_hsa030100.36624020
148Regulation of autophagy_Homo sapiens_hsa041400.36454329
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36449422
150Glioma_Homo sapiens_hsa052140.34659397
151Sulfur metabolism_Homo sapiens_hsa009200.32841913
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32265488
153Sulfur relay system_Homo sapiens_hsa041220.31554631
154Type II diabetes mellitus_Homo sapiens_hsa049300.30208185
155N-Glycan biosynthesis_Homo sapiens_hsa005100.29111687
156Oocyte meiosis_Homo sapiens_hsa041140.24620254
157Inositol phosphate metabolism_Homo sapiens_hsa005620.23917957
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.23146215
159Metabolic pathways_Homo sapiens_hsa011000.21966478
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.21707298
161Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19820638
162Circadian rhythm_Homo sapiens_hsa047100.19702913

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