MBL1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sarcomere organization (GO:0060297)4.39684199
2cellular ketone body metabolic process (GO:0046950)4.35327891
3ketone body metabolic process (GO:1902224)4.12816260
4response to pheromone (GO:0019236)4.09065454
5behavioral response to nicotine (GO:0035095)3.75597911
6regulation of action potential (GO:0098900)3.68910019
7regulation of glucokinase activity (GO:0033131)3.68423074
8regulation of hexokinase activity (GO:1903299)3.68423074
9L-fucose catabolic process (GO:0042355)3.68353915
10fucose catabolic process (GO:0019317)3.68353915
11L-fucose metabolic process (GO:0042354)3.68353915
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43996572
13atrial cardiac muscle cell action potential (GO:0086014)3.24458719
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23161296
15plasma membrane repair (GO:0001778)3.12213104
16protein localization to cilium (GO:0061512)3.10707147
17muscle cell cellular homeostasis (GO:0046716)3.07606363
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06030270
19dopamine transport (GO:0015872)3.02431083
20negative regulation of nitric-oxide synthase activity (GO:0051001)3.01240180
21epithelial cilium movement (GO:0003351)2.96174088
22cornea development in camera-type eye (GO:0061303)2.94451315
23regulation of skeletal muscle contraction (GO:0014819)2.94372264
24intraciliary transport (GO:0042073)2.91036723
25retinal cone cell development (GO:0046549)2.90598285
26protein complex biogenesis (GO:0070271)2.89265371
27cilium morphogenesis (GO:0060271)2.84126609
28limb bud formation (GO:0060174)2.82317934
29behavioral response to ethanol (GO:0048149)2.79260062
30nucleobase catabolic process (GO:0046113)2.76277898
31positive regulation of growth hormone secretion (GO:0060124)2.73996802
32negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.72693914
33pyrimidine nucleobase catabolic process (GO:0006208)2.72092954
34ribonucleoprotein complex disassembly (GO:0032988)2.69080984
35regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69024095
36coenzyme catabolic process (GO:0009109)2.68165438
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68057669
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.68057669
39NADH dehydrogenase complex assembly (GO:0010257)2.68057669
40insulin secretion (GO:0030073)2.67629780
41ubiquinone metabolic process (GO:0006743)2.67544519
42regulation of dopamine secretion (GO:0014059)2.66711597
43polyol catabolic process (GO:0046174)2.63490229
44platelet dense granule organization (GO:0060155)2.62487151
45cilium organization (GO:0044782)2.60010379
46lymphangiogenesis (GO:0001946)2.59008187
47inositol phosphate catabolic process (GO:0071545)2.58894482
48detection of light stimulus involved in sensory perception (GO:0050962)2.58775681
49detection of light stimulus involved in visual perception (GO:0050908)2.58775681
50positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57989228
51kidney morphogenesis (GO:0060993)2.57893163
52regulation of type B pancreatic cell apoptotic process (GO:2000674)2.57830536
53indole-containing compound catabolic process (GO:0042436)2.57654921
54indolalkylamine catabolic process (GO:0046218)2.57654921
55tryptophan catabolic process (GO:0006569)2.57654921
56cilium assembly (GO:0042384)2.57012776
57auditory behavior (GO:0031223)2.56476173
58cilium movement (GO:0003341)2.56212615
59glycosphingolipid biosynthetic process (GO:0006688)2.55537597
60regulation of neurotransmitter uptake (GO:0051580)2.53109644
61ubiquinone biosynthetic process (GO:0006744)2.52908181
62renal tubule morphogenesis (GO:0061333)2.52330045
63mitochondrial respiratory chain complex assembly (GO:0033108)2.51141499
64S-adenosylmethionine metabolic process (GO:0046500)2.50659700
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49626385
66somite rostral/caudal axis specification (GO:0032525)2.48521223
67sulfation (GO:0051923)2.47370240
68neuron cell-cell adhesion (GO:0007158)2.46918940
69regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.45955600
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.45955600
71positive regulation of glycolytic process (GO:0045821)2.45230523
72neuronal action potential (GO:0019228)2.43495286
73response to muscle activity (GO:0014850)2.39761727
74regulation of synaptic transmission, dopaminergic (GO:0032225)2.36643830
75synaptic transmission, cholinergic (GO:0007271)2.35552135
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.34924725
77protein polyglutamylation (GO:0018095)2.34715904
78action potential (GO:0001508)2.33398812
79organelle disassembly (GO:1903008)2.32973443
80negative regulation of telomere maintenance (GO:0032205)2.32782218
81endocrine pancreas development (GO:0031018)2.31306691
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.30209218
83cellular component assembly involved in morphogenesis (GO:0010927)2.28407280
84positive regulation of gastrulation (GO:2000543)2.27946786
85dentate gyrus development (GO:0021542)2.27360103
86nonmotile primary cilium assembly (GO:0035058)2.27307508
87activation of protein kinase B activity (GO:0032148)2.27162609
88positive regulation of catecholamine secretion (GO:0033605)2.26724917
89regulation of membrane repolarization (GO:0060306)2.26524361
90lactate metabolic process (GO:0006089)2.26371040
91prenylation (GO:0097354)2.25927118
92protein prenylation (GO:0018342)2.25927118
93quinone biosynthetic process (GO:1901663)2.25741762
94nephron epithelium morphogenesis (GO:0072088)2.25616082
95nephron tubule morphogenesis (GO:0072078)2.25616082
96positive regulation of amine transport (GO:0051954)2.25526040
97negative regulation of mast cell activation (GO:0033004)2.24776181
98water-soluble vitamin biosynthetic process (GO:0042364)2.24258191
99presynaptic membrane assembly (GO:0097105)2.24175050
100reflex (GO:0060004)2.24152239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79859240
2VDR_22108803_ChIP-Seq_LS180_Human3.76127618
3GBX2_23144817_ChIP-Seq_PC3_Human3.43976018
4ZNF274_21170338_ChIP-Seq_K562_Hela3.28616979
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80393166
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78525222
7IGF1R_20145208_ChIP-Seq_DFB_Human2.74573062
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64105331
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43257509
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34386761
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32804759
12FUS_26573619_Chip-Seq_HEK293_Human2.21858267
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15832615
14P300_19829295_ChIP-Seq_ESCs_Human2.09343146
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91352421
16EWS_26573619_Chip-Seq_HEK293_Human1.90919965
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.87234902
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.80159375
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80082713
20SMAD4_21799915_ChIP-Seq_A2780_Human1.79475920
21ER_23166858_ChIP-Seq_MCF-7_Human1.73498147
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.72612220
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68383232
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67125147
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66688740
26EZH2_22144423_ChIP-Seq_EOC_Human1.62148304
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59685206
28BCAT_22108803_ChIP-Seq_LS180_Human1.59318625
29TAF15_26573619_Chip-Seq_HEK293_Human1.57499972
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56907982
31CBP_20019798_ChIP-Seq_JUKART_Human1.56907982
32STAT3_23295773_ChIP-Seq_U87_Human1.55215935
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.53338911
34AR_25329375_ChIP-Seq_VCAP_Human1.51768248
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51709922
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48613457
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.47484471
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46598649
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46431267
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44629378
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41297210
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40284586
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40248249
44TCF4_23295773_ChIP-Seq_U87_Human1.38073036
45* TCF4_22108803_ChIP-Seq_LS180_Human1.34694384
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30203850
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29494541
48RUNX2_22187159_ChIP-Seq_PCA_Human1.28632758
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27796516
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27434686
51NANOG_19829295_ChIP-Seq_ESCs_Human1.25994825
52SOX2_19829295_ChIP-Seq_ESCs_Human1.25994825
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.25279901
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25214451
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23925452
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23154147
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22435915
58RNF2_27304074_Chip-Seq_NSC_Mouse1.21814104
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20729924
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20297987
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20174344
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18526855
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18526855
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.17874159
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17173403
66CDX2_22108803_ChIP-Seq_LS180_Human1.16426864
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.16289446
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.14464170
69REST_21632747_ChIP-Seq_MESCs_Mouse1.12953187
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12700298
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.12024911
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11041739
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.10919653
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09240761
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08813737
76TBL1_22424771_ChIP-Seq_293T_Human1.07378985
77TP53_22573176_ChIP-Seq_HFKS_Human1.06299911
78TP53_18474530_ChIP-ChIP_U2OS_Human1.04374051
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03814771
80P53_22387025_ChIP-Seq_ESCs_Mouse1.03689254
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03210276
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.03086617
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.02970539
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02642963
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01959011
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00601633
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00465109
88AHR_22903824_ChIP-Seq_MCF-7_Human1.00438930
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.00398281
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.99669905
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99669905
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.99555428
93HTT_18923047_ChIP-ChIP_STHdh_Human0.99040101
94CJUN_26792858_Chip-Seq_BT549_Human0.98358934
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97977926
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.96472654
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96028407
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95929625
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.95885489
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95862655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.63011509
2MP0002837_dystrophic_cardiac_calcinosis3.17544880
3MP0006072_abnormal_retinal_apoptosis2.76434984
4MP0000569_abnormal_digit_pigmentation2.52645673
5MP0003950_abnormal_plasma_membrane2.45414734
6MP0003195_calcinosis2.37087963
7MP0009046_muscle_twitch2.35035939
8MP0003283_abnormal_digestive_organ2.16787545
9MP0010386_abnormal_urinary_bladder2.13232665
10MP0005551_abnormal_eye_electrophysiolog2.07815461
11MP0004885_abnormal_endolymph2.06546866
12MP0005187_abnormal_penis_morphology2.06006707
13MP0000749_muscle_degeneration2.02515762
14MP0005174_abnormal_tail_pigmentation2.01671059
15MP0002822_catalepsy1.93020330
16MP0005253_abnormal_eye_physiology1.87718498
17MP0005646_abnormal_pituitary_gland1.78149374
18MP0002909_abnormal_adrenal_gland1.66826463
19MP0001984_abnormal_olfaction1.66072091
20MP0002938_white_spotting1.60510065
21MP0003880_abnormal_central_pattern1.60006962
22MP0001501_abnormal_sleep_pattern1.58387082
23MP0009745_abnormal_behavioral_response1.57089551
24MP0005367_renal/urinary_system_phenotyp1.54775555
25MP0000516_abnormal_urinary_system1.54775555
26MP0002638_abnormal_pupillary_reflex1.54186008
27MP0004133_heterotaxia1.54177797
28MP0005645_abnormal_hypothalamus_physiol1.52938417
29MP0001968_abnormal_touch/_nociception1.50724351
30MP0000372_irregular_coat_pigmentation1.50685787
31MP0002272_abnormal_nervous_system1.45760614
32MP0001486_abnormal_startle_reflex1.43750286
33MP0000015_abnormal_ear_pigmentation1.41873422
34MP0001529_abnormal_vocalization1.41837918
35MP0001905_abnormal_dopamine_level1.40656371
36MP0000013_abnormal_adipose_tissue1.37403556
37MP0003252_abnormal_bile_duct1.30235949
38MP0008872_abnormal_physiological_respon1.29244876
39MP0010368_abnormal_lymphatic_system1.28632464
40MP0003136_yellow_coat_color1.27978013
41MP0006292_abnormal_olfactory_placode1.26349329
42MP0000631_abnormal_neuroendocrine_gland1.24324981
43MP0004084_abnormal_cardiac_muscle1.23820875
44MP0004142_abnormal_muscle_tone1.23499209
45MP0002160_abnormal_reproductive_system1.23454442
46MP0004145_abnormal_muscle_electrophysio1.22113222
47MP0004215_abnormal_myocardial_fiber1.20984639
48MP0002095_abnormal_skin_pigmentation1.17753723
49MP0001188_hyperpigmentation1.17440921
50MP0002735_abnormal_chemical_nociception1.17275418
51MP0006036_abnormal_mitochondrial_physio1.16491467
52MP0001485_abnormal_pinna_reflex1.14876192
53MP0003646_muscle_fatigue1.14132021
54MP0006276_abnormal_autonomic_nervous1.13365083
55MP0002928_abnormal_bile_duct1.12688538
56MP0009780_abnormal_chondrocyte_physiolo1.12139580
57MP0001502_abnormal_circadian_rhythm1.11851122
58MP0003787_abnormal_imprinting1.10972008
59MP0002876_abnormal_thyroid_physiology1.10527433
60MP0008775_abnormal_heart_ventricle1.10013032
61MP0004924_abnormal_behavior1.08866353
62MP0005386_behavior/neurological_phenoty1.08866353
63MP0005171_absent_coat_pigmentation1.07900370
64MP0002127_abnormal_cardiovascular_syste1.06719981
65MP0004270_analgesia1.06416135
66MP0002572_abnormal_emotion/affect_behav1.05269340
67MP0002751_abnormal_autonomic_nervous1.05054571
68MP0002064_seizures1.04555619
69MP0008877_abnormal_DNA_methylation1.03157941
70MP0002090_abnormal_vision1.02494205
71MP0008875_abnormal_xenobiotic_pharmacok1.01586326
72MP0003635_abnormal_synaptic_transmissio1.01181563
73MP0002736_abnormal_nociception_after1.00904749
74MP0001986_abnormal_taste_sensitivity1.00202223
75MP0002067_abnormal_sensory_capabilities0.98858285
76MP0000427_abnormal_hair_cycle0.98773984
77MP0002184_abnormal_innervation0.97969703
78MP0002557_abnormal_social/conspecific_i0.97849852
79MP0003122_maternal_imprinting0.97343186
80MP0005620_abnormal_muscle_contractility0.96472054
81MP0000538_abnormal_urinary_bladder0.94787322
82MP0004272_abnormal_basement_membrane0.93131692
83MP0004742_abnormal_vestibular_system0.92079876
84MP0005332_abnormal_amino_acid0.90637056
85MP0000230_abnormal_systemic_arterial0.88381321
86MP0003137_abnormal_impulse_conducting0.88016322
87MP0001944_abnormal_pancreas_morphology0.86437223
88MP0002295_abnormal_pulmonary_circulatio0.85981400
89MP0002229_neurodegeneration0.83392915
90MP0004085_abnormal_heartbeat0.83173701
91MP0002734_abnormal_mechanical_nocicepti0.82399458
92MP0004036_abnormal_muscle_relaxation0.81780644
93MP0001324_abnormal_eye_pigmentation0.81309769
94MP0001756_abnormal_urination0.80076471
95MP0002138_abnormal_hepatobiliary_system0.79169588
96MP0003011_delayed_dark_adaptation0.78561244
97MP0000026_abnormal_inner_ear0.77906315
98MP0004043_abnormal_pH_regulation0.76835993
99MP0005084_abnormal_gallbladder_morpholo0.76834983
100MP0005389_reproductive_system_phenotype0.76607226

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)4.72530096
2Muscle hypertrophy of the lower extremities (HP:0008968)4.08579748
3Pancreatic fibrosis (HP:0100732)3.85902244
4Nephronophthisis (HP:0000090)3.74548808
5Molar tooth sign on MRI (HP:0002419)3.73495742
6Abnormality of midbrain morphology (HP:0002418)3.73495742
7Congenital stationary night blindness (HP:0007642)3.72352848
8Pancreatic cysts (HP:0001737)3.69048788
9Hemiparesis (HP:0001269)3.50179501
10Abnormality of the renal cortex (HP:0011035)3.28708087
11Type II lissencephaly (HP:0007260)3.21072435
12Abnormality of the renal medulla (HP:0100957)3.19676843
13True hermaphroditism (HP:0010459)3.18132815
14Renal cortical cysts (HP:0000803)3.06745693
15Gaze-evoked nystagmus (HP:0000640)2.92059133
16Medial flaring of the eyebrow (HP:0010747)2.86461706
17Inability to walk (HP:0002540)2.74118748
18Exercise-induced muscle cramps (HP:0003710)2.64389931
19Febrile seizures (HP:0002373)2.60763530
20Hypoplasia of the fovea (HP:0007750)2.59883709
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.59883709
22Attenuation of retinal blood vessels (HP:0007843)2.57638917
23Progressive cerebellar ataxia (HP:0002073)2.53715040
24Progressive macrocephaly (HP:0004481)2.52676396
25Prolonged QT interval (HP:0001657)2.51673345
26Cerebellar dysplasia (HP:0007033)2.50314876
27Acute necrotizing encephalopathy (HP:0006965)2.50234856
28Abnormal rod and cone electroretinograms (HP:0008323)2.46989438
29Ketoacidosis (HP:0001993)2.38389316
30Large for gestational age (HP:0001520)2.36327703
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.34967752
32Hypoplastic ischia (HP:0003175)2.34136217
33Cystic liver disease (HP:0006706)2.29793973
34Delayed gross motor development (HP:0002194)2.28015196
35Abnormality of the calf musculature (HP:0001430)2.27348243
36Increased corneal curvature (HP:0100692)2.25515004
37Keratoconus (HP:0000563)2.25515004
38Tubular atrophy (HP:0000092)2.24872203
39Bile duct proliferation (HP:0001408)2.22951891
40Abnormal biliary tract physiology (HP:0012439)2.22951891
41Chronic hepatic failure (HP:0100626)2.22074295
42Congenital, generalized hypertrichosis (HP:0004540)2.21403061
43Abnormality of the fovea (HP:0000493)2.21352971
44Furrowed tongue (HP:0000221)2.20950071
45Gait imbalance (HP:0002141)2.17150245
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.17120424
47Absent/shortened dynein arms (HP:0200106)2.17120424
48Abnormality of the ischium (HP:0003174)2.14859165
49Hypothermia (HP:0002045)2.14761121
50Congenital sensorineural hearing impairment (HP:0008527)2.12325572
51Hyperventilation (HP:0002883)2.10147102
52Dialeptic seizures (HP:0011146)2.06638113
53Abnormal EKG (HP:0003115)2.06079270
54Acute encephalopathy (HP:0006846)2.04748434
55Abnormal mitochondria in muscle tissue (HP:0008316)2.04322481
56Intestinal atresia (HP:0011100)2.04063360
57Hyperinsulinemic hypoglycemia (HP:0000825)2.03020524
58Congenital primary aphakia (HP:0007707)2.02075546
59Mitochondrial inheritance (HP:0001427)2.01939459
60Pendular nystagmus (HP:0012043)2.01922888
61Hamartoma of the eye (HP:0010568)2.01837300
62Anencephaly (HP:0002323)1.96918948
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96035429
64Limb dystonia (HP:0002451)1.95808936
65Bony spicule pigmentary retinopathy (HP:0007737)1.94546286
66Severe muscular hypotonia (HP:0006829)1.94411407
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.93431199
68Abolished electroretinogram (ERG) (HP:0000550)1.92678949
69Ketosis (HP:0001946)1.92645539
70Abnormal drinking behavior (HP:0030082)1.92022497
71Polydipsia (HP:0001959)1.92022497
72Sclerocornea (HP:0000647)1.92001933
73Nephrogenic diabetes insipidus (HP:0009806)1.90669346
74Anxiety (HP:0000739)1.90615840
75Congenital hepatic fibrosis (HP:0002612)1.90481656
76Male pseudohermaphroditism (HP:0000037)1.90214608
77Optic nerve hypoplasia (HP:0000609)1.88178740
78Barrel-shaped chest (HP:0001552)1.86037179
79Increased CSF lactate (HP:0002490)1.85518037
80Abnormal ciliary motility (HP:0012262)1.85389742
81Genital tract atresia (HP:0001827)1.84599442
82Tubulointerstitial nephritis (HP:0001970)1.82638717
83Abnormal respiratory motile cilium physiology (HP:0012261)1.82183817
84Prominent supraorbital ridges (HP:0000336)1.80797256
85Abnormal respiratory epithelium morphology (HP:0012253)1.80650269
86Abnormal respiratory motile cilium morphology (HP:0005938)1.80650269
87Methylmalonic acidemia (HP:0002912)1.80465129
88Tachypnea (HP:0002789)1.79745904
89Lissencephaly (HP:0001339)1.79520692
90Hepatic necrosis (HP:0002605)1.78935488
91Hepatocellular necrosis (HP:0001404)1.78932990
92Aplasia/Hypoplasia of the macula (HP:0008059)1.78145459
93Progressive inability to walk (HP:0002505)1.77468585
94Disproportionate short-trunk short stature (HP:0003521)1.76443308
95Left ventricular hypertrophy (HP:0001712)1.76380260
96Absent speech (HP:0001344)1.76300761
97Anterior segment dysgenesis (HP:0007700)1.75660820
98Broad-based gait (HP:0002136)1.74828068
99Dyskinesia (HP:0100660)1.74265918
100Sensory axonal neuropathy (HP:0003390)1.73551832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.66474296
2FRK5.23671293
3MAP4K23.92483401
4GRK12.67311401
5CASK2.61311052
6WNK32.36951898
7ADRBK22.35081870
8TNIK2.23868397
9BMPR1B2.10473699
10PNCK1.89765653
11MARK11.89427989
12NTRK31.78567453
13FGFR21.78550685
14PAK31.74485354
15MARK31.72255046
16MAPKAPK51.71155042
17MAPK131.65542197
18MUSK1.58915012
19MYLK1.57596834
20STK38L1.45564725
21OBSCN1.45264525
22MAP3K41.39714134
23CSNK1G11.37786659
24ACVR1B1.33001652
25CSNK1G31.30006437
26CSNK1G21.27428224
27DAPK21.23419872
28NUAK11.19393681
29PHKG21.16054435
30PHKG11.16054435
31LATS11.13469863
32OXSR11.11251515
33CSNK1A1L1.09654995
34EPHB21.03694055
35EIF2AK31.02310539
36ZAK1.02236694
37FER1.01042245
38TRIM281.00245363
39PTK2B0.96355704
40MAP3K120.91339058
41MAP2K70.91095369
42DYRK20.88889885
43TIE10.86852129
44ADRBK10.86330150
45PRKCE0.86062263
46CCNB10.86012859
47TLK10.84375241
48ERBB30.82943970
49STK30.79275851
50MAPK150.78603678
51PRKCG0.78206341
52PAK60.71749922
53NLK0.69811021
54BRSK20.68356536
55BCR0.66368749
56MKNK20.64976409
57STK390.63755343
58WEE10.62877136
59CDK30.62314845
60GRK70.57910534
61CSNK1A10.57159304
62INSRR0.56467541
63PLK20.55918855
64KSR10.55865540
65AKT30.55721297
66CAMK2D0.54797459
67FGFR30.54501124
68TRPM70.54091908
69WNK40.52783901
70CDK80.52065721
71TGFBR10.50755935
72PKN10.48538764
73NTRK20.48239840
74PRKACB0.48229627
75CAMK2A0.47159370
76PRKAA20.46919677
77PIK3CA0.45612516
78LIMK10.44972571
79CAMK1G0.44826764
80NEK20.44217776
81ROCK10.44028584
82PLK30.43809965
83PRKG10.42937652
84MST40.42221996
85EPHA40.41505506
86CSNK1D0.41335319
87STK240.40721294
88PRKACA0.39669691
89GSK3A0.39619346
90MINK10.37885980
91GRK50.37879299
92RPS6KA50.34097612
93TAF10.33465083
94PRKAA10.29697571
95CDK50.28838734
96DYRK1A0.28708545
97VRK10.28444809
98CAMK10.26911710
99MAP3K70.26431403
100FLT30.24945693

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.13738545
2Butanoate metabolism_Homo sapiens_hsa006503.10224988
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06371131
4Protein export_Homo sapiens_hsa030602.62790141
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32620440
6Nitrogen metabolism_Homo sapiens_hsa009102.17448713
7Oxidative phosphorylation_Homo sapiens_hsa001902.10098847
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06660325
9Phototransduction_Homo sapiens_hsa047442.05538519
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83275999
11Linoleic acid metabolism_Homo sapiens_hsa005911.81655617
12Propanoate metabolism_Homo sapiens_hsa006401.79963854
13Parkinsons disease_Homo sapiens_hsa050121.79019055
14Insulin secretion_Homo sapiens_hsa049111.74827069
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74613092
16Tryptophan metabolism_Homo sapiens_hsa003801.72317041
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66539160
18Caffeine metabolism_Homo sapiens_hsa002321.62769449
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58730665
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57954116
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56348791
22Selenocompound metabolism_Homo sapiens_hsa004501.54262348
23Nicotine addiction_Homo sapiens_hsa050331.52787072
24Cardiac muscle contraction_Homo sapiens_hsa042601.51397463
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49578600
26Taste transduction_Homo sapiens_hsa047421.37570067
27Chemical carcinogenesis_Homo sapiens_hsa052041.33375132
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33183880
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32633691
30Circadian rhythm_Homo sapiens_hsa047101.29912225
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.27923026
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26574030
33Olfactory transduction_Homo sapiens_hsa047401.25666986
34Alzheimers disease_Homo sapiens_hsa050101.21057977
35Peroxisome_Homo sapiens_hsa041461.19425789
36Ether lipid metabolism_Homo sapiens_hsa005651.18902911
37beta-Alanine metabolism_Homo sapiens_hsa004101.18532191
38Circadian entrainment_Homo sapiens_hsa047131.11605574
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08595731
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.06754225
41Histidine metabolism_Homo sapiens_hsa003401.01399714
42GABAergic synapse_Homo sapiens_hsa047271.01105165
43Hedgehog signaling pathway_Homo sapiens_hsa043401.00420492
44Collecting duct acid secretion_Homo sapiens_hsa049660.99937964
45Folate biosynthesis_Homo sapiens_hsa007900.99357803
46Retinol metabolism_Homo sapiens_hsa008300.98673547
47ABC transporters_Homo sapiens_hsa020100.97957911
48Serotonergic synapse_Homo sapiens_hsa047260.96189731
49Regulation of autophagy_Homo sapiens_hsa041400.96074320
50Vitamin B6 metabolism_Homo sapiens_hsa007500.95877318
51Huntingtons disease_Homo sapiens_hsa050160.95581922
52Renin secretion_Homo sapiens_hsa049240.94893012
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93524034
54Cocaine addiction_Homo sapiens_hsa050300.89731527
55Fatty acid degradation_Homo sapiens_hsa000710.89208063
56Glutamatergic synapse_Homo sapiens_hsa047240.87423355
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.86750308
58Basal transcription factors_Homo sapiens_hsa030220.86010032
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84383421
60Dopaminergic synapse_Homo sapiens_hsa047280.82408146
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81193500
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80888978
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80502600
64Pyruvate metabolism_Homo sapiens_hsa006200.79964974
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77307597
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77008562
67Glycerolipid metabolism_Homo sapiens_hsa005610.76477898
68Amphetamine addiction_Homo sapiens_hsa050310.75469521
69Mineral absorption_Homo sapiens_hsa049780.75361610
70Salivary secretion_Homo sapiens_hsa049700.74111368
71Arachidonic acid metabolism_Homo sapiens_hsa005900.72688151
72Morphine addiction_Homo sapiens_hsa050320.69872310
73Homologous recombination_Homo sapiens_hsa034400.67795476
74Gastric acid secretion_Homo sapiens_hsa049710.66193935
75Calcium signaling pathway_Homo sapiens_hsa040200.65286955
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64873804
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64440442
78Metabolic pathways_Homo sapiens_hsa011000.63535360
79Oxytocin signaling pathway_Homo sapiens_hsa049210.63319998
80Pancreatic secretion_Homo sapiens_hsa049720.56765535
81Long-term depression_Homo sapiens_hsa047300.56443126
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56295024
83Glucagon signaling pathway_Homo sapiens_hsa049220.55053980
84RNA polymerase_Homo sapiens_hsa030200.53387579
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.53073026
86RNA degradation_Homo sapiens_hsa030180.50704828
87Arginine and proline metabolism_Homo sapiens_hsa003300.50702205
88Fanconi anemia pathway_Homo sapiens_hsa034600.49506638
89Ovarian steroidogenesis_Homo sapiens_hsa049130.49332952
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48658966
91Proteasome_Homo sapiens_hsa030500.48383423
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48206569
93Tyrosine metabolism_Homo sapiens_hsa003500.46902098
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46196863
95Dorso-ventral axis formation_Homo sapiens_hsa043200.44190214
96cAMP signaling pathway_Homo sapiens_hsa040240.43188862
97Basal cell carcinoma_Homo sapiens_hsa052170.42583909
98Complement and coagulation cascades_Homo sapiens_hsa046100.41619894
99Dilated cardiomyopathy_Homo sapiens_hsa054140.41459761
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41351418

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