MBD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic hypermutation of immunoglobulin genes (GO:0016446)4.44068656
2somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44068656
3telomere maintenance via semi-conservative replication (GO:0032201)4.43904716
4positive regulation of gamma-delta T cell activation (GO:0046645)4.42958555
5kinetochore organization (GO:0051383)4.30780998
6CENP-A containing nucleosome assembly (GO:0034080)4.16853260
7positive regulation of B cell differentiation (GO:0045579)4.15861134
8DNA strand elongation involved in DNA replication (GO:0006271)4.08659036
9telomere maintenance via recombination (GO:0000722)4.06828599
10chromatin remodeling at centromere (GO:0031055)4.04283050
11kinetochore assembly (GO:0051382)4.03166984
12mitotic recombination (GO:0006312)3.97557522
13immunoglobulin mediated immune response (GO:0016064)3.93722089
14DNA strand elongation (GO:0022616)3.90369140
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.89497624
16DNA replication checkpoint (GO:0000076)3.85442942
17meiotic chromosome segregation (GO:0045132)3.79278526
18DNA replication initiation (GO:0006270)3.72753219
19telomere maintenance via telomere lengthening (GO:0010833)3.70277891
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.68474017
21neutrophil activation involved in immune response (GO:0002283)3.62091557
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.54278421
23B cell mediated immunity (GO:0019724)3.53728591
24DNA replication-independent nucleosome organization (GO:0034724)3.52256413
25DNA replication-independent nucleosome assembly (GO:0006336)3.52256413
26mismatch repair (GO:0006298)3.46354277
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43070975
28DNA ligation (GO:0006266)3.38530094
29mitotic metaphase plate congression (GO:0007080)3.33589623
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32299487
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28929203
32regulation of B cell differentiation (GO:0045577)3.26941310
33positive regulation of granulocyte differentiation (GO:0030854)3.26900113
34protein K6-linked ubiquitination (GO:0085020)3.26870036
35DNA double-strand break processing (GO:0000729)3.25325727
36ribosomal small subunit assembly (GO:0000028)3.24348252
37mitotic chromosome condensation (GO:0007076)3.23876482
38DNA unwinding involved in DNA replication (GO:0006268)3.23412505
39histone exchange (GO:0043486)3.21970635
40metaphase plate congression (GO:0051310)3.19923770
41DNA topological change (GO:0006265)3.17221386
42establishment of chromosome localization (GO:0051303)3.16765504
43mitotic sister chromatid segregation (GO:0000070)3.16374551
44positive regulation of histone H3-K4 methylation (GO:0051571)3.15975300
45microtubule depolymerization (GO:0007019)3.14583683
46telomere maintenance (GO:0000723)3.14104572
47DNA synthesis involved in DNA repair (GO:0000731)3.12757826
48telomere organization (GO:0032200)3.11407090
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10976525
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07826708
51positive regulation of isotype switching (GO:0045830)3.07787427
52regulation of DNA endoreduplication (GO:0032875)3.07573254
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07476179
54negative regulation of cell killing (GO:0031342)3.07476179
55histamine secretion (GO:0001821)3.07400703
56replication fork processing (GO:0031297)3.06831319
57somatic diversification of immunoglobulins (GO:0016445)3.04686804
58protein localization to kinetochore (GO:0034501)3.03904408
59somatic recombination of immunoglobulin gene segments (GO:0016447)3.02213401
60regulation of gamma-delta T cell activation (GO:0046643)3.00618338
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98714629
62attachment of spindle microtubules to kinetochore (GO:0008608)2.95929514
63regulation of B cell receptor signaling pathway (GO:0050855)2.94349704
64positive regulation of DNA recombination (GO:0045911)2.94129551
65sister chromatid segregation (GO:0000819)2.92956800
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92599912
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92599912
68isotype switching (GO:0045190)2.92599912
69somatic diversification of immune receptors (GO:0002200)2.89324446
70telomere maintenance via telomerase (GO:0007004)2.89175148
71RNA-dependent DNA replication (GO:0006278)2.87854075
72protein localization to chromosome, centromeric region (GO:0071459)2.87568661
73DNA-dependent DNA replication (GO:0006261)2.86688778
74somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.86295759
75somatic cell DNA recombination (GO:0016444)2.86295759
76intra-S DNA damage checkpoint (GO:0031573)2.83081056
77Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82401525
78mast cell activation (GO:0045576)2.81914013
79DNA deamination (GO:0045006)2.81044000
80mast cell degranulation (GO:0043303)2.80898006
81mast cell activation involved in immune response (GO:0002279)2.80898006
82negative regulation of interleukin-12 production (GO:0032695)2.80339025
83regulation of double-strand break repair via homologous recombination (GO:0010569)2.77566671
84response to peptidoglycan (GO:0032494)2.77352848
85regulation of mitotic spindle checkpoint (GO:1903504)2.74693649
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74693649
87histone H2A acetylation (GO:0043968)2.74658929
88regulation of helicase activity (GO:0051095)2.74592770
89regulation of interferon-beta biosynthetic process (GO:0045357)2.74329615
90regulation of gamma-delta T cell differentiation (GO:0045586)2.73225280
91cellular extravasation (GO:0045123)2.72646401
92nuclear pore organization (GO:0006999)2.71802329
93DNA catabolic process, exonucleolytic (GO:0000738)2.71681132
94nuclear pore complex assembly (GO:0051292)2.71476424
95modulation by symbiont of host defense response (GO:0052031)2.70647820
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70647820
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70647820
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.70647820
99modulation by symbiont of host immune response (GO:0052553)2.70647820
100positive regulation by symbiont of host defense response (GO:0052509)2.70647820
101regulation of alpha-beta T cell proliferation (GO:0046640)2.70348148
102neutrophil activation (GO:0042119)2.68950939
103transcription-coupled nucleotide-excision repair (GO:0006283)2.67782960
104positive regulation of mast cell activation (GO:0033005)2.67444342
105respiratory burst (GO:0045730)2.67229839
106spindle checkpoint (GO:0031577)2.67056188
107mitotic sister chromatid cohesion (GO:0007064)2.66741342
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66580001
109viral mRNA export from host cell nucleus (GO:0046784)2.65452296
110myeloid cell activation involved in immune response (GO:0002275)2.63907917
111spindle assembly checkpoint (GO:0071173)2.63433917
112DNA replication (GO:0006260)2.60717143
113B cell receptor signaling pathway (GO:0050853)2.60694099
114regulation of chromatin silencing (GO:0031935)2.60417207
115DNA recombination (GO:0006310)2.60206402
116* base-excision repair (GO:0006284)2.58470139
117V(D)J recombination (GO:0033151)2.58270458
118chromosome segregation (GO:0007059)2.58116120
119regulation of histone H3-K9 methylation (GO:0051570)2.57518796
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.57378344
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57378344
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57378344
123negative regulation of sister chromatid segregation (GO:0033046)2.57378344
124positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57293609
125regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.56556771
126regulation of antigen processing and presentation (GO:0002577)2.56036995
127ATP-dependent chromatin remodeling (GO:0043044)2.55607246
128negative regulation of T cell mediated immunity (GO:0002710)2.55493293
129positive regulation of B cell mediated immunity (GO:0002714)2.55447206
130positive regulation of immunoglobulin mediated immune response (GO:0002891)2.55447206
131negative regulation of chromosome segregation (GO:0051985)2.54286300
132negative regulation of phagocytosis (GO:0050765)2.54244523
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52354088
134DNA replication-dependent nucleosome assembly (GO:0006335)2.52186931
135DNA replication-dependent nucleosome organization (GO:0034723)2.52186931
136leukocyte degranulation (GO:0043299)2.51571698
137mitotic nuclear envelope disassembly (GO:0007077)2.51559593
138mitotic spindle assembly checkpoint (GO:0007094)2.50150748
139centriole replication (GO:0007099)2.49899343
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49640706
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49537576
142mature B cell differentiation (GO:0002335)2.49008898
143DNA demethylation (GO:0080111)2.48973838
144detection of other organism (GO:0098543)2.48836442
145proteasome assembly (GO:0043248)2.48378420
146regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46489191
147regulation of telomere maintenance via telomerase (GO:0032210)2.46104001
148regulation of spindle organization (GO:0090224)2.45582559
149defense response to protozoan (GO:0042832)2.45326711
150positive regulation of B cell activation (GO:0050871)2.42536380
151granulocyte activation (GO:0036230)2.39088169
152regulation of granulocyte differentiation (GO:0030852)2.38834738
153antigen processing and presentation of endogenous antigen (GO:0019883)2.38294864
154detection of bacterium (GO:0016045)2.38137467
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36972757
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36739186
157actin nucleation (GO:0045010)2.36726907
158positive regulation of mast cell degranulation (GO:0043306)2.36709745
159positive regulation of mast cell activation involved in immune response (GO:0033008)2.36709745
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35867050
161phospholipid scrambling (GO:0017121)2.33153968
162regulation of mast cell degranulation (GO:0043304)2.31602625
163regulation of mast cell activation (GO:0033003)2.31218963
164regulation of hypersensitivity (GO:0002883)2.31105253
165negative thymic T cell selection (GO:0045060)2.30869722
166B cell proliferation (GO:0042100)2.30045149
167regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29116025
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26953132
169positive regulation of immunoglobulin production (GO:0002639)2.26805979
170B cell activation involved in immune response (GO:0002312)2.24809348
171response to protozoan (GO:0001562)2.24258512
172macrophage activation involved in immune response (GO:0002281)2.24196700
173positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23451688
174lymphocyte proliferation (GO:0046651)2.22718773
175positive regulation of interleukin-17 production (GO:0032740)2.21644997
176positive regulation of histone methylation (GO:0031062)2.21594050
177production of molecular mediator involved in inflammatory response (GO:0002532)2.21212215
178negative T cell selection (GO:0043383)2.20976584
179antigen receptor-mediated signaling pathway (GO:0050851)2.20909029
180protein K11-linked ubiquitination (GO:0070979)2.18558257
181regulation of B cell apoptotic process (GO:0002902)2.18209299
182negative regulation of lymphocyte mediated immunity (GO:0002707)2.18138795
183mononuclear cell proliferation (GO:0032943)2.17369426
184meiosis I (GO:0007127)2.17179038
185neutrophil mediated immunity (GO:0002446)2.17103605
186regulation of B cell mediated immunity (GO:0002712)2.13328577
187regulation of mast cell activation involved in immune response (GO:0033006)2.12565053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.63710671
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44411625
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34521598
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06761575
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97375087
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.69773668
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59773833
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58828149
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.49286215
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.27826036
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24645013
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21901048
13VDR_23849224_ChIP-Seq_CD4+_Human2.07807722
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05874245
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.05693999
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.04819554
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04780363
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02497993
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00514166
20FOXP3_21729870_ChIP-Seq_TREG_Human2.00404099
21E2F7_22180533_ChIP-Seq_HELA_Human10.2077966
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.97852955
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97777059
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97472509
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.96086424
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95415358
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93182959
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88410002
29ELK1_19687146_ChIP-ChIP_HELA_Human1.88406051
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88284278
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.87152476
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83523396
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83512086
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83409232
35CIITA_25753668_ChIP-Seq_RAJI_Human1.83101774
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82148169
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81717275
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77640454
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76472719
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75287519
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.74501034
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73953766
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70941662
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70369989
45GATA1_22025678_ChIP-Seq_K562_Human1.62142444
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61146490
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.58377462
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52547985
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50626311
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49200338
51GATA3_26560356_Chip-Seq_TH2_Human1.46833982
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.46338340
53* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45161013
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44889655
55* SPI1_23547873_ChIP-Seq_NB4_Human1.42885125
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42075999
57XRN2_22483619_ChIP-Seq_HELA_Human1.40252171
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38364547
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38198191
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36297342
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36271767
62DCP1A_22483619_ChIP-Seq_HELA_Human1.35929504
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35816556
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34083562
65TTF2_22483619_ChIP-Seq_HELA_Human1.30655275
66SPI1_23127762_ChIP-Seq_K562_Human1.30220200
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27976113
68GATA3_27048872_Chip-Seq_THYMUS_Human1.27872703
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27121211
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27120707
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.25776773
72IRF1_19129219_ChIP-ChIP_H3396_Human1.25295499
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25133163
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24586471
75AR_21909140_ChIP-Seq_LNCAP_Human1.23473568
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23316721
77RUNX_20019798_ChIP-Seq_JUKART_Human1.22592272
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22522332
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22375076
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22077390
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22034694
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21821648
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21779058
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.21134618
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.20345790
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.20314088
87SCL_19346495_ChIP-Seq_HPC-7_Human1.19538604
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16905762
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14238019
90MYC_18940864_ChIP-ChIP_HL60_Human1.13922653
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13188280
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12706480
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12360447
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11642317
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11248780
96GABP_19822575_ChIP-Seq_HepG2_Human1.09405170
97EWS_26573619_Chip-Seq_HEK293_Human1.08624478
98VDR_24763502_ChIP-Seq_THP-1_Human1.06564343
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04917189
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03066549
101MYB_26560356_Chip-Seq_TH2_Human1.03064106
102MYC_22102868_ChIP-Seq_BL_Human1.02196623
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00401440
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99033466
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98610715
106FUS_26573619_Chip-Seq_HEK293_Human0.97968180
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97356066
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96555218
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93384420
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93147911
111MYB_26560356_Chip-Seq_TH1_Human0.93067535
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91689525
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91335509
114GATA3_26560356_Chip-Seq_TH1_Human0.88501127
115MAF_26560356_Chip-Seq_TH1_Human0.88312148
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.88000802
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87282404
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87242689
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86752396
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86404601
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84872609
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82461861
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82162050
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.80001598
125KDM5A_27292631_Chip-Seq_BREAST_Human0.77727899
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75362887
127TFEB_21752829_ChIP-Seq_HELA_Human0.73927017
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72213806
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.70387689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.37028925
2MP0008057_abnormal_DNA_replication3.90538257
3MP0003111_abnormal_nucleus_morphology3.53949853
4MP0003693_abnormal_embryo_hatching3.47774672
5MP0008058_abnormal_DNA_repair3.28075423
6* MP0003077_abnormal_cell_cycle2.88050102
7MP0000566_synostosis2.71372369
8MP0001835_abnormal_antigen_presentation2.62579152
9MP0006292_abnormal_olfactory_placode2.53729268
10MP0003656_abnormal_erythrocyte_physiolo2.51544963
11MP0002396_abnormal_hematopoietic_system2.49717509
12MP0001188_hyperpigmentation2.48855030
13MP0008877_abnormal_DNA_methylation2.41058416
14MP0008007_abnormal_cellular_replicative2.36836188
15MP0005671_abnormal_response_to2.34645988
16MP0004957_abnormal_blastocyst_morpholog2.33650480
17MP0003763_abnormal_thymus_physiology2.24187117
18MP0003724_increased_susceptibility_to2.14994634
19MP0001800_abnormal_humoral_immune2.08027829
20MP0003436_decreased_susceptibility_to1.99409875
21MP0008932_abnormal_embryonic_tissue1.94137290
22MP0002138_abnormal_hepatobiliary_system1.91343767
23MP0003806_abnormal_nucleotide_metabolis1.88014076
24MP0005464_abnormal_platelet_physiology1.87820138
25MP0002398_abnormal_bone_marrow1.80471062
26MP0001853_heart_inflammation1.79747614
27MP0005174_abnormal_tail_pigmentation1.78720710
28MP0002452_abnormal_antigen_presenting1.77242118
29MP0000015_abnormal_ear_pigmentation1.75734013
30MP0006082_CNS_inflammation1.69542750
31MP0003787_abnormal_imprinting1.69361834
32MP0002420_abnormal_adaptive_immunity1.65037179
33MP0008260_abnormal_autophagy1.64750253
34MP0001819_abnormal_immune_cell1.61780960
35MP0003300_gastrointestinal_ulcer1.61558854
36MP0001845_abnormal_inflammatory_respons1.57533338
37MP0002723_abnormal_immune_serum1.57361213
38MP0003786_premature_aging1.55982500
39MP0003136_yellow_coat_color1.55711931
40MP0009697_abnormal_copulation1.54719921
41MP0005387_immune_system_phenotype1.51208995
42MP0001790_abnormal_immune_system1.51208995
43MP0000689_abnormal_spleen_morphology1.50655207
44MP0004808_abnormal_hematopoietic_stem1.50125387
45MP0000490_abnormal_crypts_of1.50005073
46MP0002139_abnormal_hepatobiliary_system1.49832394
47MP0003828_pulmonary_edema1.49072128
48MP0000703_abnormal_thymus_morphology1.48476797
49MP0002148_abnormal_hypersensitivity_rea1.48334767
50MP0000716_abnormal_immune_system1.46628940
51MP0003172_abnormal_lysosome_physiology1.46158489
52MP0009278_abnormal_bone_marrow1.45441381
53MP0002095_abnormal_skin_pigmentation1.44545484
54MP0005000_abnormal_immune_tolerance1.44267083
55MP0002722_abnormal_immune_system1.44265907
56MP0003303_peritoneal_inflammation1.41705705
57MP0009785_altered_susceptibility_to1.40834956
58MP0000685_abnormal_immune_system1.39105787
59MP0003121_genomic_imprinting1.35177905
60MP0000465_gastrointestinal_hemorrhage1.34510318
61MP0003941_abnormal_skin_development1.34352077
62MP0005075_abnormal_melanosome_morpholog1.33451889
63MP0001986_abnormal_taste_sensitivity1.32803223
64MP0002429_abnormal_blood_cell1.31183462
65MP0005409_darkened_coat_color1.27001241
66MP0002132_abnormal_respiratory_system1.25537741
67MP0003191_abnormal_cellular_cholesterol1.24343660
68MP0006036_abnormal_mitochondrial_physio1.24275175
69MP0005025_abnormal_response_to1.24208992
70MP0008469_abnormal_protein_level1.23684417
71MP0000350_abnormal_cell_proliferation1.22703486
72MP0009333_abnormal_splenocyte_physiolog1.21359422
73MP0003880_abnormal_central_pattern1.19186502
74MP0002419_abnormal_innate_immunity1.17208877
75MP0002019_abnormal_tumor_incidence1.16566632
76MP0003195_calcinosis1.14433392
77MP0004381_abnormal_hair_follicle1.14032344
78MP0003186_abnormal_redox_activity1.11678905
79MP0010030_abnormal_orbit_morphology1.10762233
80MP0009764_decreased_sensitivity_to1.10039032
81MP0005171_absent_coat_pigmentation1.07849119
82MP0005058_abnormal_lysosome_morphology1.05950956
83* MP0000313_abnormal_cell_death1.02654017
84MP0005423_abnormal_somatic_nervous1.01660231
85MP0002006_tumorigenesis1.01199569
86MP0002210_abnormal_sex_determination0.99770631
87MP0010307_abnormal_tumor_latency0.99122519
88MP0003866_abnormal_defecation0.98868199
89MP0002163_abnormal_gland_morphology0.97231377
90MP0002277_abnormal_respiratory_mucosa0.97011569
91MP0002102_abnormal_ear_morphology0.96748228
92MP0002075_abnormal_coat/hair_pigmentati0.95732261
93MP0008004_abnormal_stomach_pH0.93946384
94MP0004947_skin_inflammation0.93525376
95MP0004147_increased_porphyrin_level0.92818875
96MP0002405_respiratory_system_inflammati0.92576285
97MP0001119_abnormal_female_reproductive0.92263988
98MP0001186_pigmentation_phenotype0.91770392
99MP0002166_altered_tumor_susceptibility0.91484228
100MP0005310_abnormal_salivary_gland0.90020114
101MP0009765_abnormal_xenobiotic_induced0.89756411
102MP0002009_preneoplasia0.86589184
103MP0005397_hematopoietic_system_phenotyp0.86471253
104MP0001545_abnormal_hematopoietic_system0.86471253
105MP0000858_altered_metastatic_potential0.86247089
106MP0003890_abnormal_embryonic-extraembry0.85834534
107MP0006035_abnormal_mitochondrial_morpho0.85486270
108MP0001929_abnormal_gametogenesis0.84659385
109MP0003252_abnormal_bile_duct0.84042781
110MP0009763_increased_sensitivity_to0.82690133
111MP0008961_abnormal_basal_metabolism0.82122191
112MP0002938_white_spotting0.79648676
113MP0001730_embryonic_growth_arrest0.78287263
114MP0001873_stomach_inflammation0.78100355
115MP0005451_abnormal_body_composition0.77833394
116MP0010155_abnormal_intestine_physiology0.77486815
117MP0000372_irregular_coat_pigmentation0.77423465
118MP0001145_abnormal_male_reproductive0.76982427
119MP0001672_abnormal_embryogenesis/_devel0.76683648
120MP0005380_embryogenesis_phenotype0.76683648
121MP0003938_abnormal_ear_development0.76162698
122MP0003123_paternal_imprinting0.75737308
123MP0002160_abnormal_reproductive_system0.75581935
124MP0005085_abnormal_gallbladder_physiolo0.75027440
125MP0001919_abnormal_reproductive_system0.73605961
126MP0001533_abnormal_skeleton_physiology0.73258596
127MP0005389_reproductive_system_phenotype0.73091566
128MP0002751_abnormal_autonomic_nervous0.72616679
129MP0006054_spinal_hemorrhage0.72228444
130MP0003183_abnormal_peptide_metabolism0.71753419
131MP0001293_anophthalmia0.71469230
132MP0004883_abnormal_blood_vessel0.69890783
133MP0009379_abnormal_foot_pigmentation0.69233043
134MP0003718_maternal_effect0.68843357
135MP0008995_early_reproductive_senescence0.68775008
136MP0000653_abnormal_sex_gland0.68499571
137MP0000569_abnormal_digit_pigmentation0.68244983
138MP0005410_abnormal_fertilization0.65514725
139MP0005360_urolithiasis0.63343230
140MP0000609_abnormal_liver_physiology0.62652140

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.60937542
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.58764068
3Abnormality of chromosome stability (HP:0003220)3.77879474
4Abnormality of the preputium (HP:0100587)3.57739276
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.56425991
6Meckel diverticulum (HP:0002245)3.56052942
7Birth length less than 3rd percentile (HP:0003561)3.55560563
8Abnormality of the ileum (HP:0001549)3.49007733
9Abnormality of macrophages (HP:0004311)3.35008568
10Reticulocytopenia (HP:0001896)3.32221816
11Duplicated collecting system (HP:0000081)3.27744856
12Agammaglobulinemia (HP:0004432)3.23799463
13Abnormality of the renal collecting system (HP:0004742)3.18209495
14Eczematoid dermatitis (HP:0000976)3.16830335
15Stomatitis (HP:0010280)3.14588198
16Clubbing of toes (HP:0100760)3.09476453
17Agnosia (HP:0010524)3.05555468
18Ectopic kidney (HP:0000086)3.02633000
19Abnormality of the prostate (HP:0008775)2.96029486
20Duodenal stenosis (HP:0100867)2.85706409
21Small intestinal stenosis (HP:0012848)2.85706409
22Abnormality of DNA repair (HP:0003254)2.81233902
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.79599654
24Myelodysplasia (HP:0002863)2.75548827
25Recurrent abscess formation (HP:0002722)2.72712786
263-Methylglutaconic aciduria (HP:0003535)2.68714720
27Vacuolated lymphocytes (HP:0001922)2.67851936
28Chronic mucocutaneous candidiasis (HP:0002728)2.62306313
29Recurrent cutaneous fungal infections (HP:0011370)2.62306313
30Osteomyelitis (HP:0002754)2.60892150
31Panhypogammaglobulinemia (HP:0003139)2.60842589
32Recurrent gram-negative bacterial infections (HP:0005420)2.59526128
33Abnormality of T cells (HP:0002843)2.57178704
34IgM deficiency (HP:0002850)2.56569474
35Bone marrow hypocellularity (HP:0005528)2.54859516
36Elevated erythrocyte sedimentation rate (HP:0003565)2.54252485
37B lymphocytopenia (HP:0010976)2.51829190
38Abnormality of B cell number (HP:0010975)2.51829190
39IgG deficiency (HP:0004315)2.50174943
40Recurrent skin infections (HP:0001581)2.49914228
41Volvulus (HP:0002580)2.46129829
42Medulloblastoma (HP:0002885)2.41655958
43Myositis (HP:0100614)2.37381257
44Abnormality of the carotid arteries (HP:0005344)2.36688312
45Meningitis (HP:0001287)2.36225121
46Abnormality of T cell physiology (HP:0011840)2.35745131
47Lymphoma (HP:0002665)2.34823741
48Vasculitis (HP:0002633)2.34816482
49Methylmalonic aciduria (HP:0012120)2.33790179
50Nephroblastoma (Wilms tumor) (HP:0002667)2.33683285
51Recurrent pneumonia (HP:0006532)2.33619329
52Loss of speech (HP:0002371)2.30742089
53Triphalangeal thumb (HP:0001199)2.29143373
54Abnormality of the duodenum (HP:0002246)2.29042480
55Recurrent viral infections (HP:0004429)2.28120343
56Recurrent bacterial skin infections (HP:0005406)2.26244764
57Abnormality of pyrimidine metabolism (HP:0004353)2.25843030
5811 pairs of ribs (HP:0000878)2.25231409
59Thyroiditis (HP:0100646)2.24800968
60Absent thumb (HP:0009777)2.24583121
61Lipid accumulation in hepatocytes (HP:0006561)2.24096897
62Duplication of thumb phalanx (HP:0009942)2.23741240
63Prostate neoplasm (HP:0100787)2.23465051
64Aplastic anemia (HP:0001915)2.22551589
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.22392904
66Sloping forehead (HP:0000340)2.18389483
67Autoimmune hemolytic anemia (HP:0001890)2.18094459
68Abnormality of liposaccharide metabolism (HP:0010968)2.17226345
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.17226345
70Abnormality of glycolipid metabolism (HP:0010969)2.17226345
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16119231
72Abnormal lung lobation (HP:0002101)2.16060755
73Leukopenia (HP:0001882)2.15556641
74Embryonal renal neoplasm (HP:0011794)2.14597161
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14153714
76Increased IgM level (HP:0003496)2.13221328
77Absent radius (HP:0003974)2.12475610
78Thrombocytosis (HP:0001894)2.09669508
79Mediastinal lymphadenopathy (HP:0100721)2.08756667
80Amaurosis fugax (HP:0100576)2.08622867
81Petechiae (HP:0000967)2.07833421
82Increased hepatocellular lipid droplets (HP:0006565)2.07750543
83Premature ovarian failure (HP:0008209)2.05717100
84Carpal bone hypoplasia (HP:0001498)2.05715492
85Prolonged bleeding time (HP:0003010)2.05579702
86Inflammation of the large intestine (HP:0002037)2.05162170
87Recurrent sinusitis (HP:0011108)2.03036734
88Abnormality of the fingertips (HP:0001211)2.02948801
89Absent forearm bone (HP:0003953)2.00911851
90Aplasia involving forearm bones (HP:0009822)2.00911851
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.99381353
92Recurrent lower respiratory tract infections (HP:0002783)1.98449413
93Spontaneous hematomas (HP:0007420)1.98290715
94Urticaria (HP:0001025)1.98192790
95Colitis (HP:0002583)1.97992469
96IgA deficiency (HP:0002720)1.97238605
97Disinhibition (HP:0000734)1.97100960
98Abnormality of incisor morphology (HP:0011063)1.92646815
99Premature graying of hair (HP:0002216)1.91384944
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91197033
101Epistaxis (HP:0000421)1.91103945
102Optic nerve coloboma (HP:0000588)1.90924864
103Optic neuritis (HP:0100653)1.90568120
104Retrobulbar optic neuritis (HP:0100654)1.90568120
105Abnormality of cochlea (HP:0000375)1.88829391
106Abnormality of the incisor (HP:0000676)1.88561383
107Severe combined immunodeficiency (HP:0004430)1.88172522
108Lymphopenia (HP:0001888)1.88116662
109Abnormality of the columella (HP:0009929)1.88078054
110Papilloma (HP:0012740)1.88054166
111Verrucae (HP:0200043)1.88054166
112Xerostomia (HP:0000217)1.87703639
113Cellulitis (HP:0100658)1.87699129
114Abnormality of lateral ventricle (HP:0030047)1.87665672
115Cerebral edema (HP:0002181)1.87510216
116Abnormal spermatogenesis (HP:0008669)1.87304309
117Gastrointestinal inflammation (HP:0004386)1.87162535
118Chronic diarrhea (HP:0002028)1.86425236
119Leukocytosis (HP:0001974)1.86394773
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86145147
121Degeneration of anterior horn cells (HP:0002398)1.85921450
122Abnormality of the anterior horn cell (HP:0006802)1.85921450
123Patellar aplasia (HP:0006443)1.85603820
124Type I transferrin isoform profile (HP:0003642)1.85556525
125Increased CSF lactate (HP:0002490)1.85383100
126Abnormality of iron homeostasis (HP:0011031)1.84934319
127Abnormality of male internal genitalia (HP:0000022)1.84778010
128Recurrent bronchitis (HP:0002837)1.84667246
129Impulsivity (HP:0100710)1.83399973
130Chronic obstructive pulmonary disease (HP:0006510)1.82691969
131Obstructive lung disease (HP:0006536)1.82691969
132Cholecystitis (HP:0001082)1.82655885
133Abnormal gallbladder physiology (HP:0012438)1.82655885
134Autoimmune thrombocytopenia (HP:0001973)1.82438333
135Chronic otitis media (HP:0000389)1.81768843
136Supernumerary spleens (HP:0009799)1.81117125
137Exertional dyspnea (HP:0002875)1.80649660
138True hermaphroditism (HP:0010459)1.80044324
139Microvesicular hepatic steatosis (HP:0001414)1.78680915
140Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78570258
141Acute lymphatic leukemia (HP:0006721)1.78028795
142Pancytopenia (HP:0001876)1.77488418
143Encephalitis (HP:0002383)1.77098300
144Tracheoesophageal fistula (HP:0002575)1.74746042
145Abnormal hair whorl (HP:0010721)1.74554709
146Short thumb (HP:0009778)1.74551477
147T lymphocytopenia (HP:0005403)1.74522843
148Aplasia/Hypoplasia of the patella (HP:0006498)1.73210922
149Abnormality of T cell number (HP:0011839)1.72940789
150Increased nuchal translucency (HP:0010880)1.71935018
151Preaxial hand polydactyly (HP:0001177)1.68766565
152Combined immunodeficiency (HP:0005387)1.68244726
153Granulocytopenia (HP:0001913)1.68227542
154Recurrent fungal infections (HP:0002841)1.66488084
155Colon cancer (HP:0003003)1.66120998
156Neutropenia (HP:0001875)1.64974272
157Abnormal number of incisors (HP:0011064)1.63281504
158Pulmonary fibrosis (HP:0002206)1.63147928
159Gastrointestinal stroma tumor (HP:0100723)1.62890901
160Abnormality of eosinophils (HP:0001879)1.62703278
161Breast hypoplasia (HP:0003187)1.61208817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.52144879
2BCKDK4.03011780
3MST43.69995835
4CDC73.39838005
5SRPK12.61026378
6MAP4K12.44142068
7STK162.27189417
8TXK2.24156234
9TAOK32.19186359
10TEC2.17018755
11WEE12.13725595
12MAP3K132.12667357
13ZAK2.11595866
14CCNB12.08876771
15VRK12.01984231
16CASK1.92684904
17TESK21.92658212
18NEK21.90874595
19MAP3K141.85523123
20CDK81.85019374
21TLK11.83536584
22ATR1.76827217
23EIF2AK11.72137212
24ACVR1B1.70013357
25TTK1.69411679
26PLK41.67366152
27MKNK11.64588004
28IRAK41.63956476
29CLK11.61213056
30PLK11.53802056
31PLK31.53376303
32MKNK21.52841106
33BTK1.49756023
34NME21.42676854
35TSSK61.37677879
36BRD41.37212718
37ITK1.36625102
38ARAF1.34119982
39ERN11.32543303
40TBK11.31974165
41STK41.31011851
42TRIM281.28994815
43CSK1.28838056
44KIT1.27220658
45AURKB1.27143530
46BLK1.24354760
47MAP4K21.22896526
48EIF2AK31.22375180
49EIF2AK21.22333034
50TGFBR21.22271514
51SYK1.21610602
52CHEK21.20619458
53IRAK31.20477776
54FES1.15748364
55BRSK21.14925700
56YES11.13791030
57SIK31.10916446
58CDK121.08288747
59MARK31.04513537
60STK241.01753266
61LYN1.01315870
62CDK71.00555407
63BMPR20.98650485
64GRK60.97291433
65DYRK30.96790491
66PIM10.93821741
67CDK40.93789517
68MELK0.91382252
69RAF10.91277702
70CHEK10.91258534
71ATM0.89507631
72CDK30.87545579
73CSF1R0.81815761
74RIPK40.80832288
75MAP3K120.80682700
76NEK10.78794827
77IKBKB0.77860739
78PIK3CG0.77539452
79TAOK20.75551928
80PRKCQ0.75037531
81RPS6KA40.74974346
82RPS6KB20.73769891
83FGFR30.72590965
84PASK0.71838426
85LCK0.70067888
86ADRBK20.69661027
87MAP3K100.69587513
88AKT30.69473558
89ZAP700.69033532
90TNIK0.66681246
91FLT30.66510418
92JAK20.65647758
93MOS0.64500939
94BMPR1B0.64465582
95GRK70.63221106
96CDK20.60207381
97BRSK10.59980784
98SGK20.57628589
99AURKA0.57438822
100NLK0.57178833
101NUAK10.57127468
102PLK20.57032091
103STK100.56672411
104BRAF0.56193890
105JAK10.55918029
106TNK20.55502227
107NEK60.55373133
108ERBB30.55291605
109MAP2K70.53662342
110PDK20.52543593
111CDK10.52098287
112JAK30.52021959
113CDK90.51670750
114MAP3K90.50608187
115CDK190.49877296
116CSNK2A10.49818620
117IKBKE0.49367843
118CHUK0.48772481
119PBK0.48402325
120TRPM70.48086028
121IRAK20.47845531
122LRRK20.46935532
123MAP3K80.46573765
124CSNK2A20.46309678
125MAPK70.45623453
126VRK20.44933991
127TGFBR10.44751916
128ABL10.44192477
129HCK0.43447422
130MAP2K30.42980777
131PRKCI0.42013981
132IRAK10.41288890
133OXSR10.41089963
134STK30.41079827
135FGR0.40655670
136MAPK130.39512837
137STK38L0.39355511
138GRK10.38771811
139TYK20.37813804
140MATK0.36644359
141PRPF4B0.36181701

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40984873
2Mismatch repair_Homo sapiens_hsa034304.07369010
3* Base excision repair_Homo sapiens_hsa034103.43013230
4Fanconi anemia pathway_Homo sapiens_hsa034603.29975891
5Homologous recombination_Homo sapiens_hsa034403.27822395
6Non-homologous end-joining_Homo sapiens_hsa034502.67193487
7Nucleotide excision repair_Homo sapiens_hsa034202.56259883
8Primary immunodeficiency_Homo sapiens_hsa053402.49212585
9Spliceosome_Homo sapiens_hsa030402.33556411
10RNA polymerase_Homo sapiens_hsa030202.31904718
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31616980
12Staphylococcus aureus infection_Homo sapiens_hsa051502.30347973
13Cell cycle_Homo sapiens_hsa041102.28641790
14Ribosome_Homo sapiens_hsa030101.90185289
15Pyrimidine metabolism_Homo sapiens_hsa002401.88120767
16Basal transcription factors_Homo sapiens_hsa030221.87779778
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.81404402
18RNA transport_Homo sapiens_hsa030131.81063607
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75431980
20RNA degradation_Homo sapiens_hsa030181.75257270
21Proteasome_Homo sapiens_hsa030501.56866803
22Allograft rejection_Homo sapiens_hsa053301.52181284
23One carbon pool by folate_Homo sapiens_hsa006701.50627413
24Graft-versus-host disease_Homo sapiens_hsa053321.47873517
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47855120
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.42625227
27mRNA surveillance pathway_Homo sapiens_hsa030151.37599488
28Herpes simplex infection_Homo sapiens_hsa051681.35895931
29p53 signaling pathway_Homo sapiens_hsa041151.30982276
30Propanoate metabolism_Homo sapiens_hsa006401.26656936
31Oxidative phosphorylation_Homo sapiens_hsa001901.24742466
32Autoimmune thyroid disease_Homo sapiens_hsa053201.19726587
33Antigen processing and presentation_Homo sapiens_hsa046121.17661693
34B cell receptor signaling pathway_Homo sapiens_hsa046621.16524399
35Purine metabolism_Homo sapiens_hsa002301.15793376
36Measles_Homo sapiens_hsa051621.12861553
37Systemic lupus erythematosus_Homo sapiens_hsa053221.11321820
38Hematopoietic cell lineage_Homo sapiens_hsa046401.03241697
39Epstein-Barr virus infection_Homo sapiens_hsa051691.00933552
40Parkinsons disease_Homo sapiens_hsa050120.99062589
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96671464
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95259553
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.94614834
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90685553
45Phagosome_Homo sapiens_hsa041450.90275305
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89437483
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86793894
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83728226
49HTLV-I infection_Homo sapiens_hsa051660.79516254
50Type I diabetes mellitus_Homo sapiens_hsa049400.78012853
51Lysosome_Homo sapiens_hsa041420.77721760
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77132763
53Leishmaniasis_Homo sapiens_hsa051400.75940016
54Regulation of autophagy_Homo sapiens_hsa041400.74652634
55Viral carcinogenesis_Homo sapiens_hsa052030.71514537
56T cell receptor signaling pathway_Homo sapiens_hsa046600.69106181
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68224399
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67103357
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66833629
60Protein export_Homo sapiens_hsa030600.64617289
61Hepatitis B_Homo sapiens_hsa051610.64325225
62Influenza A_Homo sapiens_hsa051640.63763992
63Oocyte meiosis_Homo sapiens_hsa041140.63024863
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60262073
65Apoptosis_Homo sapiens_hsa042100.59722164
66Notch signaling pathway_Homo sapiens_hsa043300.58161749
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58026189
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57759009
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55497393
70Collecting duct acid secretion_Homo sapiens_hsa049660.55313036
71Asthma_Homo sapiens_hsa053100.55022832
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54852072
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54009744
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53882926
75Osteoclast differentiation_Homo sapiens_hsa043800.49461429
76Other glycan degradation_Homo sapiens_hsa005110.47965768
77Viral myocarditis_Homo sapiens_hsa054160.46586030
78Legionellosis_Homo sapiens_hsa051340.46297354
79MicroRNAs in cancer_Homo sapiens_hsa052060.46127935
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.45885849
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45833884
82N-Glycan biosynthesis_Homo sapiens_hsa005100.44710464
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43290584
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.42121915
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41993487
86Rheumatoid arthritis_Homo sapiens_hsa053230.41670888
87Alcoholism_Homo sapiens_hsa050340.41493992
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.40938003
89Tuberculosis_Homo sapiens_hsa051520.40308679
90Shigellosis_Homo sapiens_hsa051310.39711410
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39016223
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38483306
93Glutathione metabolism_Homo sapiens_hsa004800.38389695
94Fatty acid elongation_Homo sapiens_hsa000620.36544689
95Arachidonic acid metabolism_Homo sapiens_hsa005900.36217580
96Phototransduction_Homo sapiens_hsa047440.35833413
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34707903
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34139709
99Platelet activation_Homo sapiens_hsa046110.33770059
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31493128
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31197424
102Chemokine signaling pathway_Homo sapiens_hsa040620.30374219
103Caffeine metabolism_Homo sapiens_hsa002320.30267537
104Colorectal cancer_Homo sapiens_hsa052100.30113954
105TNF signaling pathway_Homo sapiens_hsa046680.28976233
106Huntingtons disease_Homo sapiens_hsa050160.28756162
107Pathways in cancer_Homo sapiens_hsa052000.27870518
108Basal cell carcinoma_Homo sapiens_hsa052170.27001898
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26402143
110Small cell lung cancer_Homo sapiens_hsa052220.26148619
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25477876
112African trypanosomiasis_Homo sapiens_hsa051430.22820061
113FoxO signaling pathway_Homo sapiens_hsa040680.20469346
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20190455
115Prostate cancer_Homo sapiens_hsa052150.19466400
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18128788
117Acute myeloid leukemia_Homo sapiens_hsa052210.16746950
118Thyroid cancer_Homo sapiens_hsa052160.16703353
119Pancreatic cancer_Homo sapiens_hsa052120.16230739
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15701761
121Pertussis_Homo sapiens_hsa051330.15025053
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.14725178
123Malaria_Homo sapiens_hsa051440.13334090
124Toxoplasmosis_Homo sapiens_hsa051450.13333660

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