MBD3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.57669017
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.68170019
3regulation of meiosis I (GO:0060631)6.31639018
4regulation of acrosome reaction (GO:0060046)6.28610998
5metaphase plate congression (GO:0051310)6.02885445
6regulation of exit from mitosis (GO:0007096)5.97900354
7monoubiquitinated protein deubiquitination (GO:0035520)5.71407315
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.70408784
9maturation of 5.8S rRNA (GO:0000460)5.55316706
10regulation of meiosis (GO:0040020)5.38126165
11positive regulation of uterine smooth muscle contraction (GO:0070474)5.35363346
12negative regulation of hormone metabolic process (GO:0032351)5.30228866
13negative regulation of hormone biosynthetic process (GO:0032353)5.30228866
14establishment of chromosome localization (GO:0051303)5.21163266
15DNA damage response, signal transduction resulting in transcription (GO:0042772)5.12268180
16multicellular organism reproduction (GO:0032504)5.07012417
17regulation of spindle organization (GO:0090224)4.98121437
18regulation of cytokine production involved in inflammatory response (GO:1900015)4.97596458
19piRNA metabolic process (GO:0034587)4.91387773
20DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.87176690
21mitotic chromosome condensation (GO:0007076)4.85112515
22oocyte maturation (GO:0001556)4.82025986
23histone H2A monoubiquitination (GO:0035518)4.75454877
24protein K6-linked ubiquitination (GO:0085020)4.71304261
25regulation of histone H3-K27 methylation (GO:0061085)4.71222780
26mitotic sister chromatid segregation (GO:0000070)4.65459202
27female gamete generation (GO:0007292)4.64453558
28meiotic chromosome segregation (GO:0045132)4.62876249
29negative regulation of meiosis (GO:0045835)4.58757549
30positive regulation of megakaryocyte differentiation (GO:0045654)4.48405936
31meiosis I (GO:0007127)4.41194376
32DNA damage induced protein phosphorylation (GO:0006975)4.40398514
33protein localization to chromosome, centromeric region (GO:0071459)4.38124281
34regulation of retinoic acid receptor signaling pathway (GO:0048385)4.37204711
35regulation of sister chromatid cohesion (GO:0007063)4.36735371
36protein localization to kinetochore (GO:0034501)4.33287652
37attachment of spindle microtubules to kinetochore (GO:0008608)4.33053818
38male meiosis (GO:0007140)4.32748209
39male meiosis I (GO:0007141)4.32136771
40meiotic cell cycle (GO:0051321)4.26506983
41regulation of meiotic cell cycle (GO:0051445)4.25718017
42DNA replication checkpoint (GO:0000076)4.25578163
43regulation of glucocorticoid metabolic process (GO:0031943)4.25155922
44regulation of mitotic spindle organization (GO:0060236)4.23550713
45protein kinase C signaling (GO:0070528)4.18949352
46regulation of uterine smooth muscle contraction (GO:0070472)4.17567803
47positive regulation of chromosome segregation (GO:0051984)4.09597565
48CENP-A containing nucleosome assembly (GO:0034080)4.04012984
49regulation of chromosome segregation (GO:0051983)4.03541130
50positive regulation of humoral immune response (GO:0002922)4.02479488
51regulation of RIG-I signaling pathway (GO:0039535)3.98238082
52protein localization to chromosome (GO:0034502)3.98220340
53spindle checkpoint (GO:0031577)3.97396337
54regulation of female receptivity (GO:0045924)3.95863727
55myoblast migration (GO:0051451)3.94850551
56histone H2A ubiquitination (GO:0033522)3.94138103
57synaptonemal complex assembly (GO:0007130)3.92825757
58drinking behavior (GO:0042756)3.92665546
59chromosome segregation (GO:0007059)3.92249955
60aggressive behavior (GO:0002118)3.89435933
61histone exchange (GO:0043486)3.87342509
62chromatin remodeling at centromere (GO:0031055)3.86486749
63DNA replication-independent nucleosome organization (GO:0034724)3.81406287
64DNA replication-independent nucleosome assembly (GO:0006336)3.81406287
65regulation of female gonad development (GO:2000194)3.80123115
66regulation of penile erection (GO:0060405)3.79253810
67snRNA transcription (GO:0009301)3.78854872
68sister chromatid segregation (GO:0000819)3.72978754
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.70666989
70hyperosmotic salinity response (GO:0042538)3.70321480
71positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.69668161
72female gonad development (GO:0008585)3.67803846
73positive regulation of prostaglandin secretion (GO:0032308)3.62090691
74sister chromatid cohesion (GO:0007062)3.59579818
75glycerophospholipid catabolic process (GO:0046475)3.57653063
76regulation of establishment of cell polarity (GO:2000114)3.55134371
77synaptonemal complex organization (GO:0070193)3.53981850
78meiotic cell cycle process (GO:1903046)3.49779287
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49301194
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49301194
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.49301194
82negative regulation of DNA-templated transcription, elongation (GO:0032785)3.49139734
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.49139734
84reproduction (GO:0000003)3.44333081
85female mating behavior (GO:0060180)3.42127967
86meiotic nuclear division (GO:0007126)3.41588167
87oocyte development (GO:0048599)3.41092414
88mitotic spindle checkpoint (GO:0071174)3.40874974
89mitotic nuclear envelope disassembly (GO:0007077)3.40833041
90maturation of SSU-rRNA (GO:0030490)3.39250110
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39213614
92inner cell mass cell proliferation (GO:0001833)3.38893973
93positive regulation of catecholamine secretion (GO:0033605)3.38256808
94type B pancreatic cell development (GO:0003323)3.38226533
95microtubule nucleation (GO:0007020)3.37929736
96rRNA modification (GO:0000154)3.37190211
97kinetochore assembly (GO:0051382)3.37112789
98negative regulation of reproductive process (GO:2000242)3.36798415
99negative regulation of alcohol biosynthetic process (GO:1902931)3.36460881
100regulation of transforming growth factor beta2 production (GO:0032909)3.34801563
101positive regulation of digestive system process (GO:0060456)3.34653771
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.34137026
103rRNA methylation (GO:0031167)3.32417882
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31906034
105sleep (GO:0030431)3.31781435
106resolution of meiotic recombination intermediates (GO:0000712)3.31745807
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31443013
108microtubule depolymerization (GO:0007019)3.31213952
109regulation of DNA methylation (GO:0044030)3.31082634
110response to acidic pH (GO:0010447)3.30533163
111regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.29587979
112vitamin transmembrane transport (GO:0035461)3.27915121
113mitotic sister chromatid cohesion (GO:0007064)3.26004414
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25745017
115negative regulation of digestive system process (GO:0060457)3.23435059
116membrane disassembly (GO:0030397)3.21635218
117nuclear envelope disassembly (GO:0051081)3.21635218
118positive regulation of DNA-dependent DNA replication (GO:2000105)3.20338267
119regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19006863
120negative regulation of chromosome segregation (GO:0051985)3.18865643
121regulation of establishment or maintenance of cell polarity (GO:0032878)3.16950637
122negative regulation of mitotic sister chromatid separation (GO:2000816)3.15715385
123negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15715385
124negative regulation of sister chromatid segregation (GO:0033046)3.15715385
125glycine transport (GO:0015816)3.14483127
126binding of sperm to zona pellucida (GO:0007339)3.08123903
127regulation of prostaglandin secretion (GO:0032306)3.08018103
128cellular response to pH (GO:0071467)2.87931501
129transcription from mitochondrial promoter (GO:0006390)2.87420178
130chaperone-mediated protein transport (GO:0072321)2.85214457
131regulation of norepinephrine secretion (GO:0014061)2.81089591
132positive regulation of reproductive process (GO:2000243)2.77940592
133maternal behavior (GO:0042711)2.59797302
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.50380495
135termination of RNA polymerase III transcription (GO:0006386)2.50380495
136viral transcription (GO:0019083)2.45187280
137ribosomal small subunit biogenesis (GO:0042274)2.41903769
138translational termination (GO:0006415)2.41898169
139sperm-egg recognition (GO:0035036)2.40908852
140autophagic vacuole assembly (GO:0000045)2.36424423
141telomere maintenance via telomere lengthening (GO:0010833)2.32226999
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.31489718
143single fertilization (GO:0007338)2.30003280
144parental behavior (GO:0060746)2.28067289
145L-amino acid import (GO:0043092)2.26086768
146chaperone mediated protein folding requiring cofactor (GO:0051085)2.25261193
147chromosome condensation (GO:0030261)2.24244275
148histone H3-K9 demethylation (GO:0033169)2.23431641
149ribosome assembly (GO:0042255)2.23165094
150N-terminal protein amino acid acetylation (GO:0006474)2.22557189
151positive regulation of icosanoid secretion (GO:0032305)2.20927202
152positive regulation of renal sodium excretion (GO:0035815)2.12700208
153ventricular cardiac muscle cell development (GO:0055015)2.12022439
154response to food (GO:0032094)2.09881072
155translational elongation (GO:0006414)2.08369974
156negative regulation of RNA splicing (GO:0033119)2.08351471
157translational initiation (GO:0006413)2.06988096
158regulation of calcium ion-dependent exocytosis (GO:0017158)2.06000550
159regulation of reproductive process (GO:2000241)1.98751206
160positive regulation of fatty acid transport (GO:2000193)1.97993780
161cellular protein complex disassembly (GO:0043624)1.97409690
162regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)1.96917632
163SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.94086478
164rRNA processing (GO:0006364)1.93687360
165regulation of alternative mRNA splicing, via spliceosome (GO:0000381)1.91565433
166muscle organ morphogenesis (GO:0048644)1.90723822
167cell-cell recognition (GO:0009988)1.90680811
168cotranslational protein targeting to membrane (GO:0006613)1.89726982
169positive regulation of protein homooligomerization (GO:0032464)1.89691535
170C21-steroid hormone biosynthetic process (GO:0006700)1.88475822
171regulation of G2/M transition of mitotic cell cycle (GO:0010389)1.88312238
172grooming behavior (GO:0007625)1.87723458
173regulation of urine volume (GO:0035809)1.87667017
174transcription elongation from RNA polymerase II promoter (GO:0006368)1.87538536
175regulation of steroid hormone secretion (GO:2000831)1.87214125
176fertilization (GO:0009566)1.86970472
177amino acid import (GO:0043090)1.86920350
178protein targeting to ER (GO:0045047)1.84905532
179ribonucleoprotein complex biogenesis (GO:0022613)1.84033224
180rRNA metabolic process (GO:0016072)1.83389635
181sensory perception of taste (GO:0050909)1.82891545
182viral life cycle (GO:0019058)1.82833635
183DNA packaging (GO:0006323)1.79876541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.70439820
2E2F7_22180533_ChIP-Seq_HELA_Human5.20906330
3NOTCH1_21737748_ChIP-Seq_TLL_Human4.87390121
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.84322728
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.84322728
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.84322728
7EZH2_22144423_ChIP-Seq_EOC_Human4.60878103
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.49076879
9KAP1_22055183_ChIP-Seq_ESCs_Mouse4.41212248
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24609900
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19405561
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.05605903
13AR_21909140_ChIP-Seq_LNCAP_Human3.72777890
14ZNF274_21170338_ChIP-Seq_K562_Hela3.35594624
15SMAD_19615063_ChIP-ChIP_OVARY_Human3.34174296
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.29691115
17E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06776376
18ETV1_20927104_ChIP-Seq_GIST48_Human2.89622125
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.81541022
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.77101105
21RBPJ_21746931_ChIP-Seq_IB4_Human2.76566320
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55667890
23NFYB_21822215_ChIP-Seq_K562_Human2.53364495
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51504705
25PHF8_20622853_ChIP-Seq_HELA_Human2.37679438
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35742150
27GATA1_26923725_Chip-Seq_HPCs_Mouse2.35480690
28GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.30483592
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.28177226
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.26383077
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17483556
32GATA6_21074721_ChIP-Seq_CACO-2_Human2.12268701
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07153751
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse2.02376543
35TP63_19390658_ChIP-ChIP_HaCaT_Human2.02170173
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02092571
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.92993557
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92772289
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83081619
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.82599667
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80267919
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.77360009
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71605825
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70890769
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66454094
46RUNX1_26923725_Chip-Seq_HPCs_Mouse1.62550063
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62395529
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61833232
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59760950
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58419774
51TTF2_22483619_ChIP-Seq_HELA_Human1.56539310
52XRN2_22483619_ChIP-Seq_HELA_Human1.55564893
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54979956
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52691407
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50076692
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47997390
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47538853
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47406485
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46566695
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46505853
61NANOG_20526341_ChIP-Seq_ESCs_Human1.41542175
62IGF1R_20145208_ChIP-Seq_DFB_Human1.40748487
63FOXP3_21729870_ChIP-Seq_TREG_Human1.38501237
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38028078
65PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.36530109
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.35776183
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33360563
68STAT1_20625510_ChIP-Seq_HELA_Human1.31171369
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30598376
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29737228
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29381835
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29297367
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29154927
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28865674
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23706174
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22463448
77RAC3_21632823_ChIP-Seq_H3396_Human1.20626872
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20477052
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17523667
80KAP1_27257070_Chip-Seq_ESCs_Mouse1.17050000
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.16958102
82ELK1_19687146_ChIP-ChIP_HELA_Human1.14623321
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13699507
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13424132
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.12258023
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.11258856
87CTCF_20526341_ChIP-Seq_ESCs_Human1.10583028
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10105648
89KDM5A_27292631_Chip-Seq_BREAST_Human1.09456992
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09181136
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08114543
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06620892
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06500940
94* MYC_18940864_ChIP-ChIP_HL60_Human1.05988551
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05688671
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05292496
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04638950
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04638950
99FUS_26573619_Chip-Seq_HEK293_Human1.04317749
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04015125
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03737570
102* STAT1_17558387_ChIP-Seq_HELA_Human1.01609441
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01360181
104RNF2_27304074_Chip-Seq_NSC_Mouse1.00903490
105GABP_19822575_ChIP-Seq_HepG2_Human0.99664023
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.98917459
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98242561
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97883832
109CDX2_22108803_ChIP-Seq_LS180_Human0.96466937
110ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96204480
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96023908
112* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94909018
113CTCF_21964334_Chip-Seq_Bcells_Human0.94897275
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94557124
115* SOX2_21211035_ChIP-Seq_LN229_Human0.94007811
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93518289
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93234782
118CBX2_22325352_ChIP-Seq_293T-Rex_Human0.93051930
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92568764
120CIITA_25753668_ChIP-Seq_RAJI_Human0.92000772
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91159312
122ERG_20517297_ChIP-Seq_VCAP_Human0.90792673
123* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90233242
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90155619
125FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90100763
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89807452
127* E2F1_20622854_ChIP-Seq_HELA_Human0.88623897
128GATA3_21867929_ChIP-Seq_TH1_Mouse0.87185124
129CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87166874
130P53_21459846_ChIP-Seq_SAOS-2_Human0.86985930
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86820485
132JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85192476
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85120805
134TP53_22573176_ChIP-Seq_HFKS_Human0.84489790
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.83429687
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.83206653
137SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.82488847
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81346976
139* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81286942
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81182053
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80876423
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79696765
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79661215
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.79655208
145STAT3_23295773_ChIP-Seq_U87_Human0.79641685
146VDR_23849224_ChIP-Seq_CD4+_Human0.78934428
147EWS_26573619_Chip-Seq_HEK293_Human0.78857191
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78420865
149TBL1_22424771_ChIP-Seq_293T_Human0.78418956
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78301919
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78295340
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78245075
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77903693
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.77553135
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77302534
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.77203126
157NFYA_21822215_ChIP-Seq_K562_Human0.77073798
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76817738
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76428992
160E2F1_18555785_ChIP-Seq_MESCs_Mouse0.75810094
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.75779080
162SOX2_18555785_Chip-Seq_ESCs_Mouse0.74835130
163ETS1_20019798_ChIP-Seq_JURKAT_Human0.74050755
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.74002837
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73821593
166NCOR_22424771_ChIP-Seq_293T_Human0.72637244
167CTCF_26484167_Chip-Seq_Bcells_Mouse0.71098155
168PHF8_20622854_ChIP-Seq_HELA_Human0.70728616
169IRF1_19129219_ChIP-ChIP_H3396_Human0.70650762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.36455615
2MP0001986_abnormal_taste_sensitivity5.20428063
3MP0003693_abnormal_embryo_hatching5.17868567
4MP0003718_maternal_effect5.00959231
5MP0002102_abnormal_ear_morphology4.98695388
6MP0005423_abnormal_somatic_nervous4.65719695
7MP0009379_abnormal_foot_pigmentation4.56655686
8MP0003646_muscle_fatigue4.30265400
9MP0003111_abnormal_nucleus_morphology3.59529332
10MP0008877_abnormal_DNA_methylation3.35901249
11MP0003077_abnormal_cell_cycle3.32266062
12MP0010094_abnormal_chromosome_stability3.21696111
13MP0002653_abnormal_ependyma_morphology3.20543105
14MP0009840_abnormal_foam_cell3.18654047
15MP0005499_abnormal_olfactory_system3.08025694
16MP0005394_taste/olfaction_phenotype3.08025694
17MP0004957_abnormal_blastocyst_morpholog2.96884240
18MP0003123_paternal_imprinting2.83787886
19MP0005410_abnormal_fertilization2.83639667
20MP0006292_abnormal_olfactory_placode2.54023562
21MP0002127_abnormal_cardiovascular_syste2.39481136
22MP0006276_abnormal_autonomic_nervous2.37959494
23MP0005408_hypopigmentation2.33287138
24MP0001119_abnormal_female_reproductive2.32004548
25MP0008007_abnormal_cellular_replicative2.22686889
26MP0003699_abnormal_female_reproductive2.19143040
27MP0005360_urolithiasis2.18320265
28MP0005395_other_phenotype2.17759615
29MP0008789_abnormal_olfactory_epithelium2.11067121
30MP0001881_abnormal_mammary_gland2.10645435
31MP0001929_abnormal_gametogenesis2.06462162
32MP0002210_abnormal_sex_determination2.01722807
33MP0000653_abnormal_sex_gland2.00139805
34MP0002277_abnormal_respiratory_mucosa1.99577664
35MP0008057_abnormal_DNA_replication1.90447632
36MP0003937_abnormal_limbs/digits/tail_de1.76245171
37MP0001730_embryonic_growth_arrest1.73498737
38MP0008932_abnormal_embryonic_tissue1.71793110
39MP0002249_abnormal_larynx_morphology1.71401895
40MP0003787_abnormal_imprinting1.68213769
41MP0000462_abnormal_digestive_system1.67967873
42MP0001529_abnormal_vocalization1.62703499
43MP0004185_abnormal_adipocyte_glucose1.62262481
44MP0008058_abnormal_DNA_repair1.60577304
45MP0003121_genomic_imprinting1.57304114
46MP0001145_abnormal_male_reproductive1.57007567
47MP0000350_abnormal_cell_proliferation1.57000766
48MP0001502_abnormal_circadian_rhythm1.53505995
49MP0005310_abnormal_salivary_gland1.48610077
50MP0000579_abnormal_nail_morphology1.48362591
51MP0010030_abnormal_orbit_morphology1.48143747
52MP0002138_abnormal_hepatobiliary_system1.48085555
53MP0002085_abnormal_embryonic_tissue1.46916355
54MP0001697_abnormal_embryo_size1.40524427
55MP0004142_abnormal_muscle_tone1.40292674
56MP0002254_reproductive_system_inflammat1.39772601
57MP0010307_abnormal_tumor_latency1.38667237
58MP0001672_abnormal_embryogenesis/_devel1.35773777
59MP0005380_embryogenesis_phenotype1.35773777
60MP0003315_abnormal_perineum_morphology1.32639748
61MP0003136_yellow_coat_color1.28139520
62MP0002161_abnormal_fertility/fecundity1.26313088
63MP0002084_abnormal_developmental_patter1.25110421
64MP0001545_abnormal_hematopoietic_system1.19467349
65MP0005397_hematopoietic_system_phenotyp1.19467349
66MP0000372_irregular_coat_pigmentation1.13525734
67MP0004264_abnormal_extraembryonic_tissu1.08517529
68MP0008260_abnormal_autophagy1.05574195
69MP0001919_abnormal_reproductive_system1.04906871
70MP0002877_abnormal_melanocyte_morpholog1.03702303
71MP0001851_eye_inflammation1.02934986
72MP0003984_embryonic_growth_retardation1.02725322
73MP0008995_early_reproductive_senescence0.99138085
74MP0003698_abnormal_male_reproductive0.98559963
75MP0002088_abnormal_embryonic_growth/wei0.98078773
76MP0005646_abnormal_pituitary_gland0.97799627
77MP0004233_abnormal_muscle_weight0.97567736
78MP0000639_abnormal_adrenal_gland0.96910884
79MP0010234_abnormal_vibrissa_follicle0.95211548
80MP0003755_abnormal_palate_morphology0.94386462
81MP0003195_calcinosis0.93910608
82MP0003786_premature_aging0.93439870
83MP0004215_abnormal_myocardial_fiber0.91886213
84MP0003283_abnormal_digestive_organ0.90596948
85MP0005647_abnormal_sex_gland0.88272870
86MP0001666_abnormal_nutrient_absorption0.87963553
87MP0001293_anophthalmia0.87954035
88MP0002080_prenatal_lethality0.87611866
89MP0002086_abnormal_extraembryonic_tissu0.86048016
90MP0002019_abnormal_tumor_incidence0.84838932
91MP0005621_abnormal_cell_physiology0.84657030
92MP0003938_abnormal_ear_development0.84212965
93MP0002163_abnormal_gland_morphology0.83274247
94MP0001440_abnormal_grooming_behavior0.82125495
95MP0003221_abnormal_cardiomyocyte_apopto0.81925303
96MP0001346_abnormal_lacrimal_gland0.81814524
97MP0010368_abnormal_lymphatic_system0.81426477
98MP0005257_abnormal_intraocular_pressure0.79919621
99MP0003941_abnormal_skin_development0.79573723
100MP0001915_intracranial_hemorrhage0.78603610
101MP0001849_ear_inflammation0.76346908
102MP0009333_abnormal_splenocyte_physiolog0.74933303
103MP0001905_abnormal_dopamine_level0.74768234
104MP0009250_abnormal_appendicular_skeleto0.74165481
105MP0003866_abnormal_defecation0.74066585
106MP0002269_muscular_atrophy0.73864686
107MP0005187_abnormal_penis_morphology0.73629278
108MP0003186_abnormal_redox_activity0.71726784
109MP0003656_abnormal_erythrocyte_physiolo0.70965184
110MP0002396_abnormal_hematopoietic_system0.70160267
111MP0000490_abnormal_crypts_of0.69805646
112MP0000432_abnormal_head_morphology0.68084500
113MP0005076_abnormal_cell_differentiation0.67908990
114MP0006036_abnormal_mitochondrial_physio0.67603231
115MP0000049_abnormal_middle_ear0.67102159
116MP0004019_abnormal_vitamin_homeostasis0.64714075
117MP0002233_abnormal_nose_morphology0.64058069
118MP0002177_abnormal_outer_ear0.63376304
119MP0002139_abnormal_hepatobiliary_system0.63131343
120MP0003935_abnormal_craniofacial_develop0.62918745
121MP0000631_abnormal_neuroendocrine_gland0.62709570
122MP0003890_abnormal_embryonic-extraembry0.62271272
123MP0003861_abnormal_nervous_system0.59861253
124MP0001984_abnormal_olfaction0.59438253
125MP0005384_cellular_phenotype0.57943726
126MP0000613_abnormal_salivary_gland0.57733748
127MP0004145_abnormal_muscle_electrophysio0.57224518
128MP0000566_synostosis0.56672746
129MP0005389_reproductive_system_phenotype0.56407233
130MP0000762_abnormal_tongue_morphology0.55291004
131MP0003950_abnormal_plasma_membrane0.55183422
132MP0000313_abnormal_cell_death0.54178418
133MP0005197_abnormal_uvea_morphology0.53102702
134MP0004510_myositis0.53008058
135MP0009672_abnormal_birth_weight0.52380409
136MP0001968_abnormal_touch/_nociception0.52225019
137MP0000627_abnormal_mammary_gland0.51778466
138MP0002116_abnormal_craniofacial_bone0.51203356
139MP0005508_abnormal_skeleton_morphology0.49340667
140MP0004808_abnormal_hematopoietic_stem0.49090881
141MP0004270_analgesia0.48607306
142MP0000750_abnormal_muscle_regeneration0.48174812
143MP0005645_abnormal_hypothalamus_physiol0.47232549
144MP0002160_abnormal_reproductive_system0.46937506
145MP0002736_abnormal_nociception_after0.46291423
146MP0000427_abnormal_hair_cycle0.46223434
147MP0005085_abnormal_gallbladder_physiolo0.44754715
148MP0003879_abnormal_hair_cell0.44411992
149MP0003936_abnormal_reproductive_system0.44307985

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)7.21686373
2Male infertility (HP:0003251)6.14243644
3Birth length less than 3rd percentile (HP:0003561)5.84096151
4Breast hypoplasia (HP:0003187)5.39222590
5Facial hemangioma (HP:0000329)4.94966013
6Aplasia/hypoplasia of the uterus (HP:0008684)4.91554687
7Chromsome breakage (HP:0040012)4.80253854
8Papillary thyroid carcinoma (HP:0002895)4.73363385
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.63166032
10Patellar aplasia (HP:0006443)4.60534997
11Hypercortisolism (HP:0001578)4.56713983
12Aplasia/Hypoplasia of the patella (HP:0006498)4.32419289
13Sensory axonal neuropathy (HP:0003390)4.30543414
14Abnormality of the labia minora (HP:0012880)4.22576495
15Rhinitis (HP:0012384)4.21092880
16Capillary hemangiomas (HP:0005306)4.17610592
17Shawl scrotum (HP:0000049)4.04852298
18Hypoplasia of the uterus (HP:0000013)3.99176101
19Steatorrhea (HP:0002570)3.92868801
20Adrenal hypoplasia (HP:0000835)3.92621338
21Myokymia (HP:0002411)3.76195566
22Flat capital femoral epiphysis (HP:0003370)3.68914302
23Prostate neoplasm (HP:0100787)3.65945815
24Breast aplasia (HP:0100783)3.58769683
25Aplasia/Hypoplasia of the breasts (HP:0010311)3.47855887
26Anterior segment dysgenesis (HP:0007700)3.47629011
27Secondary amenorrhea (HP:0000869)3.45088655
28Reticulocytopenia (HP:0001896)3.33637563
29Muscle stiffness (HP:0003552)3.32765906
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.32563417
31Dysphonia (HP:0001618)3.27852687
32Abnormality of the septum pellucidum (HP:0007375)3.27057738
33Carpal bone hypoplasia (HP:0001498)3.26221406
34Fat malabsorption (HP:0002630)3.22245772
35Multiple enchondromatosis (HP:0005701)3.15800109
36Acute myeloid leukemia (HP:0004808)3.15558792
37Azoospermia (HP:0000027)3.14309641
38Short tibia (HP:0005736)3.11264954
39Abnormality of lateral ventricle (HP:0030047)3.11256006
40Oligodactyly (hands) (HP:0001180)3.09322359
41Facial cleft (HP:0002006)3.06371628
42Abnormal spermatogenesis (HP:0008669)3.03117231
43Abnormality of chromosome stability (HP:0003220)3.00715316
44Progressive muscle weakness (HP:0003323)2.99664213
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.99143891
46Abnormality of the fingertips (HP:0001211)2.96870123
47Periauricular skin pits (HP:0100277)2.94100976
48Preauricular pit (HP:0004467)2.94100976
49Aplasia/Hypoplasia of the macula (HP:0008059)2.87304183
50Abnormality of the preputium (HP:0100587)2.86854517
51Pancreatic fibrosis (HP:0100732)2.83646372
52Congenital ichthyosiform erythroderma (HP:0007431)2.82163330
53Meckel diverticulum (HP:0002245)2.81924093
54Microretrognathia (HP:0000308)2.81520494
55Limb dystonia (HP:0002451)2.80019443
56Glossoptosis (HP:0000162)2.77483820
57Oligodactyly (HP:0012165)2.75164560
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.74943248
59Constricted visual fields (HP:0001133)2.74387140
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.72238881
61Impulsivity (HP:0100710)2.70192197
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70013901
63Thyroid carcinoma (HP:0002890)2.67312534
64Sparse lateral eyebrow (HP:0005338)2.65204955
65Aplasia/Hypoplasia affecting the retina (HP:0008061)2.64227721
66Selective tooth agenesis (HP:0001592)2.60793164
67Aplasia/hypoplasia of the humerus (HP:0006507)2.60617323
68Progressive hearing impairment (HP:0001730)2.60099745
69Abnormality of the ileum (HP:0001549)2.59207701
70Fused cervical vertebrae (HP:0002949)2.56768771
71Hypophosphatemic rickets (HP:0004912)2.55172815
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54698066
73Impaired proprioception (HP:0010831)2.54394911
74Patent foramen ovale (HP:0001655)2.54328274
75Cleft eyelid (HP:0000625)2.52118127
76Abnormality of cells of the erythroid lineage (HP:0012130)2.50533126
77Adrenal overactivity (HP:0002717)2.50167035
78Pulmonary fibrosis (HP:0002206)2.48287933
79Oral leukoplakia (HP:0002745)2.47572320
80Cystic hygroma (HP:0000476)2.47503882
81Abnormality of chromosome segregation (HP:0002916)2.46746219
82Premature ovarian failure (HP:0008209)2.45935601
83Absent radius (HP:0003974)2.41310311
84Lip pit (HP:0100267)2.38054676
85Progressive sensorineural hearing impairment (HP:0000408)2.37425864
86Sandal gap (HP:0001852)2.37130075
87Aplasia/Hypoplasia involving the musculature (HP:0001460)2.37078570
88Absent septum pellucidum (HP:0001331)2.34634697
89Spontaneous abortion (HP:0005268)2.32833723
90Type 2 muscle fiber atrophy (HP:0003554)2.32551666
91Mutism (HP:0002300)2.32271303
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30922134
93Aplasia involving forearm bones (HP:0009822)2.30793917
94Absent forearm bone (HP:0003953)2.30793917
95Poor eye contact (HP:0000817)2.29591064
96Delayed CNS myelination (HP:0002188)2.29308518
97Microvesicular hepatic steatosis (HP:0001414)2.29078852
98Poor suck (HP:0002033)2.28358452
99Pancreatic cysts (HP:0001737)2.27393629
100Chronic bronchitis (HP:0004469)2.27267864
101Abnormal number of erythroid precursors (HP:0012131)2.27113773
102Supernumerary spleens (HP:0009799)2.26081209
103Cortical dysplasia (HP:0002539)2.24457167
104Cortical visual impairment (HP:0100704)2.23662845
105Ragged-red muscle fibers (HP:0003200)2.23274478
106Esotropia (HP:0000565)2.22899220
107Muscle fiber atrophy (HP:0100295)2.22745156
108Trismus (HP:0000211)2.21386561
109Arterial tortuosity (HP:0005116)2.19126146
110Microglossia (HP:0000171)2.17891805
111Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17817814
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17817814
113Overlapping toe (HP:0001845)2.15824516
114Hypergonadotropic hypogonadism (HP:0000815)2.15020066
115Myelodysplasia (HP:0002863)2.14259640
116Wrist flexion contracture (HP:0001239)2.13883788
117Infertility (HP:0000789)2.13554705
118Primary amenorrhea (HP:0000786)2.13254693
119Short thumb (HP:0009778)2.12554338
120Small intestinal stenosis (HP:0012848)2.12151324
121Duodenal stenosis (HP:0100867)2.12151324
122Fibular aplasia (HP:0002990)2.10931256
123Pili torti (HP:0003777)2.09027706
124Ectopic kidney (HP:0000086)2.08773636
125Macrocytic anemia (HP:0001972)2.08717601
126Choanal stenosis (HP:0000452)2.07982321
127Testicular atrophy (HP:0000029)2.07980438
128Gout (HP:0001997)2.07034581
129Midline defect of the nose (HP:0004122)2.06425103
130Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06356938
131Insulin-resistant diabetes mellitus (HP:0000831)2.05980917
132Atrioventricular block (HP:0001678)2.05625029
133Abnormality of the proximal phalanges of the hand (HP:0009834)2.04654288
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04010303
135Atresia of the external auditory canal (HP:0000413)2.03187732
136Osteomalacia (HP:0002749)2.00264379
137Clubbing of toes (HP:0100760)2.00218304
138Attenuation of retinal blood vessels (HP:0007843)2.00171239
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.99244612
140Central scotoma (HP:0000603)1.98911792
141Anhidrosis (HP:0000970)1.95064051
142Abnormality of the epiphysis of the femoral head (HP:0010574)1.94732392
143Nonprogressive disorder (HP:0003680)1.93778243
144Spondylolisthesis (HP:0003302)1.92301936
145Sloping forehead (HP:0000340)1.91693380
146Abnormality of the prostate (HP:0008775)1.91657253
147Aplasia/Hypoplasia of the scapulae (HP:0006713)1.91631958
148Hypoplastic scapulae (HP:0000882)1.91631958
149Aplastic anemia (HP:0001915)1.90511648
150Hypoglycemic seizures (HP:0002173)1.90461093
151Progressive external ophthalmoplegia (HP:0000590)1.89942468
152Pendular nystagmus (HP:0012043)1.88183645
153Abnormality of the phalanges of the hallux (HP:0010057)1.88022323
154Hypoplastic iliac wings (HP:0002866)1.87533803
155CNS hypomyelination (HP:0003429)1.87352956
156Cone-rod dystrophy (HP:0000548)1.87263045
157Absent thumb (HP:0009777)1.87244697
158Decreased muscle mass (HP:0003199)1.86738503
159Abdominal situs inversus (HP:0003363)1.85372659
160Abnormality of abdominal situs (HP:0011620)1.85372659
161Vascular tortuosity (HP:0004948)1.84547171
162Skin pits (HP:0100276)1.84483467
163Cerebral hypomyelination (HP:0006808)1.84113389
164Cafe-au-lait spot (HP:0000957)1.83945478
165Irregular epiphyses (HP:0010582)1.83398094
166Abnormality of the fovea (HP:0000493)1.82898674
167Abnormality of the femoral head (HP:0003368)1.82433376
168Bony spicule pigmentary retinopathy (HP:0007737)1.82089426
169Rib fusion (HP:0000902)1.81841545
170Hypoplasia of the fovea (HP:0007750)1.81630639
171Aplasia/Hypoplasia of the fovea (HP:0008060)1.81630639
172Sparse eyelashes (HP:0000653)1.80270814
173Nausea (HP:0002018)1.78653053
174Enlarged penis (HP:0000040)1.78320766
175Impaired social interactions (HP:0000735)1.76586081
176Abnormal social behavior (HP:0012433)1.76586081
177Complete atrioventricular canal defect (HP:0001674)1.75275309
178Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74242862
179Abnormality of femoral epiphyses (HP:0006499)1.74242862
180Hyperglycemia (HP:0003074)1.73706155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.50154026
2LATS24.27994398
3CDK194.24396063
4LATS14.04783409
5PLK43.53805485
6MUSK3.51613731
7KSR23.44081922
8MAP3K63.39575628
9STK163.32162481
10STK38L3.25802140
11TRIM283.15949067
12ERBB43.11185341
13TAOK12.77143246
14MAP3K92.60343513
15BRAF2.59274621
16TTK2.57263867
17RAF12.49330332
18CDC72.45192200
19TAOK32.36638327
20EEF2K2.29341820
21NEK22.17439405
22EIF2AK32.15414062
23ARAF2.09151410
24MAP3K131.91528757
25STK31.89043416
26PAK61.80171151
27BRSK21.71893525
28DYRK21.70355407
29KSR11.68154348
30CHEK21.63065003
31ZAK1.63002518
32MOS1.61844347
33MAPKAPK31.56684197
34CDK81.55486612
35ACVR1B1.52716829
36PLK11.49585271
37BUB11.47236903
38LRRK21.42502352
39NME11.39651957
40MELK1.37439811
41CDK91.32443720
42TLK11.28590024
43BRSK11.19924703
44PKN11.18938599
45SRPK11.17301195
46PBK1.13804822
47PLK31.13126818
48WEE11.10732791
49PRKD31.05138871
50AURKB1.04310347
51GSK3A1.01559236
52CDK31.01059134
53NTRK30.94308750
54ABL20.93965082
55WNK10.92652599
56STK380.90534874
57PDK20.87277500
58PIM20.87251894
59MAPK130.86278077
60CSNK1E0.85833098
61DYRK30.84592433
62EIF2AK10.82003324
63CSNK2A20.78093247
64PRKD20.76787468
65WNK30.75722043
66PRKAA10.75441303
67CSNK2A10.75203914
68AURKA0.74175421
69MAP3K80.71376823
70MAPKAPK50.71354711
71KDR0.70726191
72CHEK10.69465104
73PRKAA20.67491998
74VRK10.67100934
75AKT20.67006228
76MAP3K40.66459331
77TYRO30.66380457
78STK40.66008915
79MARK20.64614380
80DMPK0.64017131
81MKNK20.63773718
82STK240.62947660
83NUAK10.62924779
84RPS6KA40.62505989
85PINK10.59486141
86CDK70.58678061
87CSNK1G10.58278902
88BMPR20.54536500
89MAP3K50.53795639
90ATM0.53605576
91CSNK1G20.48696578
92PAK20.48304849
93MAP2K70.47897642
94PIM10.47215472
95TRPM70.46005432
96STK100.45329624
97CDK120.42661696
98VRK20.42600577
99CSNK1G30.39430672
100SGK20.38904100
101RPS6KB20.38811018
102CDK40.38747262
103MAP2K40.38619643
104CDK20.38409072
105AKT30.37500413
106MAPK110.37082941
107CDK10.36950110
108TESK10.36325089
109PRKCI0.35842674
110NME20.33765152
111PRKD10.33065265
112TAOK20.31648401
113BCKDK0.31642936
114CDK11A0.30113637
115NLK0.29876207
116PAK10.28987828
117MTOR0.28036465
118ATR0.27927173
119EIF2AK20.27659816
120FRK0.26128780
121MAPK100.25616495
122JAK30.25581523
123MARK30.24402256
124NEK90.23694736
125PRKG10.23435672
126ABL10.23028181
127CCNB10.22527370
128MAPK90.22364553
129RET0.22360178
130HIPK20.21936588
131CLK10.21921577
132MAP2K10.21810759
133GSK3B0.21427531
134RPS6KA10.21131109
135CAMK2A0.20673461
136MAPK10.19987338
137CSNK1A1L0.19823204
138NEK60.19086030
139MAPKAPK20.17663186
140PAK30.16992807
141SGK2230.16629986
142PIK3CG0.15739727
143BRD40.15187255
144MAPK140.13467331
145PRKCG0.12943836
146CSNK1A10.12426553
147GRK50.11430793
148LMTK20.11317567
149PDK10.09900380
150PRKCE0.09601999
151TNK20.09547779
152CAMK10.09491622

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.20054344
2Ribosome_Homo sapiens_hsa030104.82166066
3Cell cycle_Homo sapiens_hsa041104.50362979
4RNA polymerase_Homo sapiens_hsa030204.00431736
5Basal transcription factors_Homo sapiens_hsa030223.72263622
6RNA degradation_Homo sapiens_hsa030183.29463705
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82182041
8Taste transduction_Homo sapiens_hsa047422.56326758
9Ovarian steroidogenesis_Homo sapiens_hsa049132.48237931
10RNA transport_Homo sapiens_hsa030132.48133957
11Circadian rhythm_Homo sapiens_hsa047102.47704938
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.41275164
13Homologous recombination_Homo sapiens_hsa034402.34244617
14p53 signaling pathway_Homo sapiens_hsa041152.31521499
15Oocyte meiosis_Homo sapiens_hsa041142.31504125
16Fanconi anemia pathway_Homo sapiens_hsa034602.18756942
17Linoleic acid metabolism_Homo sapiens_hsa005911.88511882
18TGF-beta signaling pathway_Homo sapiens_hsa043501.86245427
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84138419
20Pancreatic cancer_Homo sapiens_hsa052121.76185513
21Ether lipid metabolism_Homo sapiens_hsa005651.62446912
22Pyrimidine metabolism_Homo sapiens_hsa002401.53130918
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47248062
24mRNA surveillance pathway_Homo sapiens_hsa030151.44931511
25Nucleotide excision repair_Homo sapiens_hsa034201.43330759
26DNA replication_Homo sapiens_hsa030301.39683816
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37590325
28Fatty acid biosynthesis_Homo sapiens_hsa000611.33461795
29MicroRNAs in cancer_Homo sapiens_hsa052061.32206550
30GnRH signaling pathway_Homo sapiens_hsa049121.22320033
31Prolactin signaling pathway_Homo sapiens_hsa049171.21385831
32Choline metabolism in cancer_Homo sapiens_hsa052311.20947304
33Cardiac muscle contraction_Homo sapiens_hsa042601.19181898
34Base excision repair_Homo sapiens_hsa034101.18519338
35Huntingtons disease_Homo sapiens_hsa050161.17560659
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.15787523
37Purine metabolism_Homo sapiens_hsa002301.14105085
38Renal cell carcinoma_Homo sapiens_hsa052111.13880222
39Mismatch repair_Homo sapiens_hsa034301.13305878
40Colorectal cancer_Homo sapiens_hsa052101.13032438
41Dorso-ventral axis formation_Homo sapiens_hsa043201.10474549
42Steroid biosynthesis_Homo sapiens_hsa001001.08498379
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98272511
44Parkinsons disease_Homo sapiens_hsa050120.96086888
45Proteasome_Homo sapiens_hsa030500.95986529
46Sulfur metabolism_Homo sapiens_hsa009200.93856684
47Fatty acid elongation_Homo sapiens_hsa000620.92010847
48FoxO signaling pathway_Homo sapiens_hsa040680.91905472
49Non-homologous end-joining_Homo sapiens_hsa034500.91603646
50Olfactory transduction_Homo sapiens_hsa047400.87415788
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87291462
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85708882
53Thyroid cancer_Homo sapiens_hsa052160.84920140
54Folate biosynthesis_Homo sapiens_hsa007900.82369821
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.80547504
56Endometrial cancer_Homo sapiens_hsa052130.79842309
57Hippo signaling pathway_Homo sapiens_hsa043900.78766889
58VEGF signaling pathway_Homo sapiens_hsa043700.78555154
59Small cell lung cancer_Homo sapiens_hsa052220.76022030
60Spliceosome_Homo sapiens_hsa030400.71072337
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69584444
62Epstein-Barr virus infection_Homo sapiens_hsa051690.68532625
63Herpes simplex infection_Homo sapiens_hsa051680.66695424
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66671083
65mTOR signaling pathway_Homo sapiens_hsa041500.66467233
66Adherens junction_Homo sapiens_hsa045200.64999193
67Hepatitis B_Homo sapiens_hsa051610.60925571
68Pentose phosphate pathway_Homo sapiens_hsa000300.60328969
69Non-small cell lung cancer_Homo sapiens_hsa052230.57481649
70Arachidonic acid metabolism_Homo sapiens_hsa005900.56415081
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56229408
72Prostate cancer_Homo sapiens_hsa052150.54406778
73Long-term depression_Homo sapiens_hsa047300.54124172
74Bladder cancer_Homo sapiens_hsa052190.51805185
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50712161
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49508789
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.47884653
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47521118
79Inositol phosphate metabolism_Homo sapiens_hsa005620.47433265
80Regulation of autophagy_Homo sapiens_hsa041400.47333818
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46897683
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46296149
83Ras signaling pathway_Homo sapiens_hsa040140.44491448
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44418924
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42695288
86HTLV-I infection_Homo sapiens_hsa051660.42487484
87Protein export_Homo sapiens_hsa030600.41190898
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.40148530
89Chronic myeloid leukemia_Homo sapiens_hsa052200.39984513
90Notch signaling pathway_Homo sapiens_hsa043300.39860670
91Oxidative phosphorylation_Homo sapiens_hsa001900.38915667
92Biosynthesis of amino acids_Homo sapiens_hsa012300.37783194
93ABC transporters_Homo sapiens_hsa020100.37300386
94Vitamin digestion and absorption_Homo sapiens_hsa049770.37224263
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36609918
96Acute myeloid leukemia_Homo sapiens_hsa052210.36410426
97Sphingolipid metabolism_Homo sapiens_hsa006000.35457807
98Other glycan degradation_Homo sapiens_hsa005110.35088629
99Protein digestion and absorption_Homo sapiens_hsa049740.34791317
100ErbB signaling pathway_Homo sapiens_hsa040120.33480434
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33129572
102MAPK signaling pathway_Homo sapiens_hsa040100.33044207
103Estrogen signaling pathway_Homo sapiens_hsa049150.31562946
104Systemic lupus erythematosus_Homo sapiens_hsa053220.31349966
105Insulin secretion_Homo sapiens_hsa049110.30979437
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.30780673
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29711492
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28839319
109Melanoma_Homo sapiens_hsa052180.26679119
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26619089
111Viral carcinogenesis_Homo sapiens_hsa052030.26601123
112Arginine and proline metabolism_Homo sapiens_hsa003300.26496635
113Shigellosis_Homo sapiens_hsa051310.24110191
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.23834006
115Glioma_Homo sapiens_hsa052140.23140408
116Mineral absorption_Homo sapiens_hsa049780.22892122
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.22576980
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22568213
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22463643
120Pathways in cancer_Homo sapiens_hsa052000.21296671
121Morphine addiction_Homo sapiens_hsa050320.21006789
122GABAergic synapse_Homo sapiens_hsa047270.20773150
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.20710493
124AMPK signaling pathway_Homo sapiens_hsa041520.20710074
125Hedgehog signaling pathway_Homo sapiens_hsa043400.20405129
126Wnt signaling pathway_Homo sapiens_hsa043100.20245319
127Alcoholism_Homo sapiens_hsa050340.19822432
128Pyruvate metabolism_Homo sapiens_hsa006200.19673281
129Influenza A_Homo sapiens_hsa051640.18788878
130Nicotine addiction_Homo sapiens_hsa050330.17021971
131Caffeine metabolism_Homo sapiens_hsa002320.17010002
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16858910
133Serotonergic synapse_Homo sapiens_hsa047260.16369234
134Arginine biosynthesis_Homo sapiens_hsa002200.15497129
135Tight junction_Homo sapiens_hsa045300.15209043
136One carbon pool by folate_Homo sapiens_hsa006700.14602266
137Metabolic pathways_Homo sapiens_hsa011000.14529372
138Bile secretion_Homo sapiens_hsa049760.14165190
139Glutathione metabolism_Homo sapiens_hsa004800.11984482
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11960220
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11351452
142Legionellosis_Homo sapiens_hsa051340.09501570
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08750109
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08669963
145Amphetamine addiction_Homo sapiens_hsa050310.07724147
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06311784
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06297315
148Synaptic vesicle cycle_Homo sapiens_hsa047210.04014503
149Pancreatic secretion_Homo sapiens_hsa049720.02198224

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