MAVS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.37310720
2L-phenylalanine catabolic process (GO:0006559)6.37310720
3L-phenylalanine metabolic process (GO:0006558)6.18929799
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.18929799
5aromatic amino acid family catabolic process (GO:0009074)5.70104398
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.49157691
7alpha-linolenic acid metabolic process (GO:0036109)5.43790066
8glyoxylate metabolic process (GO:0046487)5.36739853
9kynurenine metabolic process (GO:0070189)5.24016862
10indole-containing compound catabolic process (GO:0042436)5.16618712
11indolalkylamine catabolic process (GO:0046218)5.16618712
12tryptophan catabolic process (GO:0006569)5.16618712
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09464672
14lysine metabolic process (GO:0006553)5.04392489
15lysine catabolic process (GO:0006554)5.04392489
16bile acid biosynthetic process (GO:0006699)5.00312666
17cysteine metabolic process (GO:0006534)4.97815022
18tryptophan metabolic process (GO:0006568)4.88714480
19sulfur amino acid catabolic process (GO:0000098)4.88637154
20regulation of fatty acid beta-oxidation (GO:0031998)4.81432494
21urea metabolic process (GO:0019627)4.64743379
22urea cycle (GO:0000050)4.64743379
23amino-acid betaine metabolic process (GO:0006577)4.63933897
24negative regulation of fibrinolysis (GO:0051918)4.60350861
25complement activation, alternative pathway (GO:0006957)4.60295248
26protein carboxylation (GO:0018214)4.58550299
27peptidyl-glutamic acid carboxylation (GO:0017187)4.58550299
28serine family amino acid catabolic process (GO:0009071)4.56765737
29high-density lipoprotein particle remodeling (GO:0034375)4.56475135
30regulation of triglyceride catabolic process (GO:0010896)4.55990207
31regulation of protein activation cascade (GO:2000257)4.53420867
32homocysteine metabolic process (GO:0050667)4.33009102
33regulation of complement activation (GO:0030449)4.27530523
34nitrogen cycle metabolic process (GO:0071941)4.26949555
35regulation of fibrinolysis (GO:0051917)4.26513175
36positive regulation of fatty acid oxidation (GO:0046321)4.25356982
37bile acid metabolic process (GO:0008206)4.20135541
38negative regulation of fatty acid transport (GO:2000192)4.15969064
39ethanol oxidation (GO:0006069)4.15472996
40glycine metabolic process (GO:0006544)4.14483357
41valine metabolic process (GO:0006573)4.14477081
42regulation of cholesterol esterification (GO:0010872)4.14098074
43alpha-amino acid catabolic process (GO:1901606)4.12057788
44aromatic amino acid family metabolic process (GO:0009072)4.11635413
452-oxoglutarate metabolic process (GO:0006103)4.09643945
46reverse cholesterol transport (GO:0043691)4.08723483
47fatty acid beta-oxidation (GO:0006635)4.04763705
48plasma lipoprotein particle clearance (GO:0034381)4.02224669
49cellular ketone body metabolic process (GO:0046950)3.98661973
50acylglycerol homeostasis (GO:0055090)3.95848498
51triglyceride homeostasis (GO:0070328)3.95848498
52plasma lipoprotein particle remodeling (GO:0034369)3.94435889
53protein-lipid complex remodeling (GO:0034368)3.94435889
54macromolecular complex remodeling (GO:0034367)3.94435889
55acetyl-CoA metabolic process (GO:0006084)3.91505796
56serine family amino acid metabolic process (GO:0009069)3.91322997
57negative regulation of sterol transport (GO:0032372)3.90562666
58negative regulation of cholesterol transport (GO:0032375)3.90562666
59phospholipid efflux (GO:0033700)3.89926712
60fatty acid oxidation (GO:0019395)3.87517198
61cellular amino acid catabolic process (GO:0009063)3.86510990
62carnitine metabolic process (GO:0009437)3.85703428
63tyrosine metabolic process (GO:0006570)3.84522854
64lipid oxidation (GO:0034440)3.80248009
65insulin-like growth factor receptor signaling pathway (GO:0048009)3.78806396
66cellular modified amino acid catabolic process (GO:0042219)3.78623188
67mannose metabolic process (GO:0006013)3.78337479
68serine family amino acid biosynthetic process (GO:0009070)3.77554700
69fatty acid catabolic process (GO:0009062)3.75228920
70aspartate family amino acid catabolic process (GO:0009068)3.72261072
71short-chain fatty acid metabolic process (GO:0046459)3.71987328
72monocarboxylic acid catabolic process (GO:0072329)3.67017234
73coenzyme catabolic process (GO:0009109)3.64926133
74plasma lipoprotein particle assembly (GO:0034377)3.64747645
75cellular glucuronidation (GO:0052695)3.64181571
76carboxylic acid catabolic process (GO:0046395)3.61591594
77organic acid catabolic process (GO:0016054)3.61591594
78benzene-containing compound metabolic process (GO:0042537)3.61449158
79phospholipid homeostasis (GO:0055091)3.59939077
80bile acid and bile salt transport (GO:0015721)3.59324217
81regulation of cholesterol homeostasis (GO:2000188)3.54852062
82indolalkylamine metabolic process (GO:0006586)3.54298918
83amine catabolic process (GO:0009310)3.52459479
84cellular biogenic amine catabolic process (GO:0042402)3.52459479
85fatty acid transmembrane transport (GO:1902001)3.52170816
86glutamate metabolic process (GO:0006536)3.51029207
87aldehyde catabolic process (GO:0046185)3.50964021
88branched-chain amino acid catabolic process (GO:0009083)3.49299498
89positive regulation of triglyceride lipase activity (GO:0061365)3.48555720
90positive regulation of lipoprotein lipase activity (GO:0051006)3.48555720
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.47283001
92cholesterol efflux (GO:0033344)3.46525991
93dicarboxylic acid biosynthetic process (GO:0043650)3.45408832
94imidazole-containing compound metabolic process (GO:0052803)3.44808743
95striated muscle atrophy (GO:0014891)3.44272794
96ketone body metabolic process (GO:1902224)3.43910689
97positive regulation of lipid catabolic process (GO:0050996)3.43847169
98very-low-density lipoprotein particle assembly (GO:0034379)3.42341779
99positive regulation of histone deacetylation (GO:0031065)3.42307279
100cholesterol homeostasis (GO:0042632)3.41896739
101regulation of cholesterol metabolic process (GO:0090181)3.39756612
102branched-chain amino acid metabolic process (GO:0009081)3.37105663
103sterol homeostasis (GO:0055092)3.36299301
104desmosome organization (GO:0002934)3.35958207
105fibrinolysis (GO:0042730)3.35434014
106urate metabolic process (GO:0046415)3.35211383
107protein-lipid complex assembly (GO:0065005)3.34019564
108regulation of fatty acid oxidation (GO:0046320)3.32555513
109complement activation, classical pathway (GO:0006958)3.29623404
110regulation of hippo signaling (GO:0035330)3.25071055
111endocardial cushion development (GO:0003197)3.23616831
112cell-substrate adherens junction assembly (GO:0007045)3.20688761
113focal adhesion assembly (GO:0048041)3.20688761
114negative regulation of cell size (GO:0045792)3.16182754
115cell-substrate junction assembly (GO:0007044)3.11747363
116skeletal muscle adaptation (GO:0043501)3.07486883
117positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06336982
118semaphorin-plexin signaling pathway (GO:0071526)3.03585121
119regulation of glucose import in response to insulin stimulus (GO:2001273)2.94412591
120adherens junction assembly (GO:0034333)2.93190885
121regulation of skeletal muscle contraction (GO:0014819)2.89895034
122interkinetic nuclear migration (GO:0022027)2.88936238
123negative regulation of protein localization to cell surface (GO:2000009)2.75038900
124negative regulation of myotube differentiation (GO:0010832)2.70883521
125response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67437964
126negative regulation of viral release from host cell (GO:1902187)2.63962122
127atrioventricular valve morphogenesis (GO:0003181)2.63070653
128regulation of tight junction assembly (GO:2000810)2.62186166
129membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.61907719
130vascular endothelial growth factor signaling pathway (GO:0038084)2.58126966
131positive regulation of protein deacetylation (GO:0090312)2.58104469
132muscle atrophy (GO:0014889)2.55072904
133endothelial cell chemotaxis (GO:0035767)2.52890373
134regulation of integrin activation (GO:0033623)2.50045953
135regulation of histone deacetylation (GO:0031063)2.50042693
136regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.48296055
137cytoplasmic mRNA processing body assembly (GO:0033962)2.46455797
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.46382324
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45837007
140positive regulation of CREB transcription factor activity (GO:0032793)2.44871465
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44347786
142hemidesmosome assembly (GO:0031581)2.44243017
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.44077317
144regulation of histone H3-K27 methylation (GO:0061085)2.42595415
145carnitine shuttle (GO:0006853)2.39208274
146venous blood vessel morphogenesis (GO:0048845)2.39109734
147negative regulation of erythrocyte differentiation (GO:0045647)2.38794550
148receptor catabolic process (GO:0032801)2.35966992
149basement membrane organization (GO:0071711)2.35872637
150embryonic camera-type eye morphogenesis (GO:0048596)2.33536134
151embryonic retina morphogenesis in camera-type eye (GO:0060059)2.32455441
152positive regulation of fatty acid metabolic process (GO:0045923)2.32278189
153regulation of somitogenesis (GO:0014807)2.30122872
154interferon-gamma secretion (GO:0072643)2.29780090
155embryonic eye morphogenesis (GO:0048048)2.29364647
156plasma membrane repair (GO:0001778)2.28157168
157flavonoid metabolic process (GO:0009812)2.28038625
158apoptotic process involved in morphogenesis (GO:0060561)2.25240306
159regulation of endothelial cell chemotaxis (GO:2001026)2.25026622
160activation of Rac GTPase activity (GO:0032863)2.23997238
161iron ion import (GO:0097286)2.21631334
162membrane repolarization during action potential (GO:0086011)2.20790681
163positive regulation of synapse maturation (GO:0090129)2.19474646
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.18884828
165negative regulation of sodium ion transport (GO:0010766)2.18721945
166negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17770430
167sarcomere organization (GO:0045214)2.16608354
168myofibril assembly (GO:0030239)2.16373866
169macroautophagy (GO:0016236)2.15208860
170cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.14373533
171snRNA transcription (GO:0009301)2.14343302
172renal filtration (GO:0097205)2.14155952
173regulation of cell proliferation involved in kidney development (GO:1901722)2.13705282
174positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.13428677
175glucocorticoid receptor signaling pathway (GO:0042921)2.13328855
176hypotonic response (GO:0006971)2.13091960
177regulation of cholesterol storage (GO:0010885)2.11669717
178cellular anion homeostasis (GO:0030002)2.10192117
179tooth mineralization (GO:0034505)2.09270347
180cell-cell junction maintenance (GO:0045217)2.08879015
181cellular response to epidermal growth factor stimulus (GO:0071364)2.08307419
182positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08117169
183regulation of establishment of cell polarity (GO:2000114)2.08054764
184regulation of extracellular matrix disassembly (GO:0010715)2.08012827
185branching involved in mammary gland duct morphogenesis (GO:0060444)2.07032137
186positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.06558045
187regulation of establishment or maintenance of cell polarity (GO:0032878)2.04687587
188cardiac myofibril assembly (GO:0055003)2.04605084
189camera-type eye morphogenesis (GO:0048593)2.04471092
190regulation of chromatin binding (GO:0035561)2.04009695
191endosome to melanosome transport (GO:0035646)2.03363794
192endosome to pigment granule transport (GO:0043485)2.03363794
193vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.01999472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.48376105
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.70824002
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.01649241
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.52053229
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.17340140
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.12612334
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.04267347
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.95693380
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.79383455
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.19002351
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.15707453
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11176079
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85720822
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.77456597
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76590109
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51618622
17GATA1_22025678_ChIP-Seq_K562_Human2.20547302
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18876303
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.09746713
20CLOCK_20551151_ChIP-Seq_293T_Human2.06067292
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04578864
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.95736057
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.92056127
24KDM2B_26808549_Chip-Seq_DND41_Human1.89980829
25KDM2B_26808549_Chip-Seq_K562_Human1.82235941
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.80852938
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68153305
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62646695
29TP53_22127205_ChIP-Seq_IMR90_Human1.59840695
30* P68_20966046_ChIP-Seq_HELA_Human1.59508829
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55851497
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51869766
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51442487
34DROSHA_22980978_ChIP-Seq_HELA_Human1.50931213
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50362812
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49847035
37VDR_24763502_ChIP-Seq_THP-1_Human1.46757185
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46297072
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44756654
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43547809
41CREB1_26743006_Chip-Seq_LNCaP_Human1.43262737
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43090840
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.42257425
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42006924
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40627942
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40258132
47SMC4_20622854_ChIP-Seq_HELA_Human1.39512377
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38601979
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36503135
50AHR_22903824_ChIP-Seq_MCF-7_Human1.35419725
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34373150
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34045742
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.34033893
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31460069
55TP53_23651856_ChIP-Seq_MEFs_Mouse1.30805902
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29831063
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27070567
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26479718
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26431446
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25956831
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24853290
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23716585
63TP63_22573176_ChIP-Seq_HFKS_Human1.23258952
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.21000758
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20018063
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19611750
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18784706
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17959764
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17507561
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.17175692
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14814108
72HNF4A_19822575_ChIP-Seq_HepG2_Human1.14737360
73ZNF263_19887448_ChIP-Seq_K562_Human1.14560711
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.14443909
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14229642
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12773291
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12030398
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06724565
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05648073
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05239772
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05174071
82STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05086917
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.04910607
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04333338
85CTCF_27219007_Chip-Seq_Bcells_Human1.04299948
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04066979
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.03712793
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.02837231
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01779585
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01451164
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01032442
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.00491283
93BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97796083
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.97771871
95RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97740735
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97709761
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96590562
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96418872
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95546131
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.95044662
101GATA4_25053715_ChIP-Seq_YYC3_Human0.94289096
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94101871
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93267083
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92318452
105* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91884845
106SCL_19346495_ChIP-Seq_HPC-7_Human0.91452666
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91177781
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.90891663
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89164930
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86810007
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84641694
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84200989
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84179004
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83969182
115GATA1_19941826_ChIP-Seq_K562_Human0.83801134
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83679677
117LXR_22292898_ChIP-Seq_THP-1_Human0.81581239
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.81314343
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80161043
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.79663778
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.79125683
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.78649332
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.78649332
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78553829
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76955734
126MYC_22102868_ChIP-Seq_BL_Human0.76321305
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75864384
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74963442
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74608609
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74085776
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.73350074
132MAF_26560356_Chip-Seq_TH1_Human0.73275476
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72885917
134GATA6_25053715_ChIP-Seq_YYC3_Human0.71646262
135RACK7_27058665_Chip-Seq_MCF-7_Human0.71612101
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.70957172
137* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70358352
138* IRF8_27001747_Chip-Seq_BMDM_Mouse0.70283547
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.68985802
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68888237
141HTT_18923047_ChIP-ChIP_STHdh_Human0.67294137
142GATA2_19941826_ChIP-Seq_K562_Human0.67246440
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.64976222
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64905480
145IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.64661420
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.64321119
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64160415
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64130970
149* ATF3_27146783_Chip-Seq_COLON_Human0.63993950
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.63700058
151BCOR_27268052_Chip-Seq_Bcells_Human0.63449526
152VDR_21846776_ChIP-Seq_THP-1_Human0.63197993
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62675053
154AR_21909140_ChIP-Seq_LNCAP_Human0.62200581
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62060713
156CEBPB_22108803_ChIP-Seq_LS180_Human0.61655283
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61133741
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.61060634
159SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61021531
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.60467262
161CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.59781062
162BP1_19119308_ChIP-ChIP_Hs578T_Human0.58467590
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58313871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.82645426
2MP0005360_urolithiasis6.24238202
3MP0005085_abnormal_gallbladder_physiolo5.06825896
4MP0005365_abnormal_bile_salt5.06272697
5MP0003806_abnormal_nucleotide_metabolis4.13137198
6MP0005409_darkened_coat_color4.09443120
7MP0008875_abnormal_xenobiotic_pharmacok4.03860056
8MP0009840_abnormal_foam_cell3.36409356
9MP0003252_abnormal_bile_duct3.34125800
10MP0010329_abnormal_lipoprotein_level3.04506253
11MP0005076_abnormal_cell_differentiation3.01246811
12MP0005083_abnormal_biliary_tract2.67915839
13MP0005332_abnormal_amino_acid2.55069617
14MP0001666_abnormal_nutrient_absorption2.42356593
15MP0003195_calcinosis2.38949220
16MP0003191_abnormal_cellular_cholesterol2.33354574
17MP0000609_abnormal_liver_physiology2.10170643
18MP0004233_abnormal_muscle_weight1.94247662
19MP0005319_abnormal_enzyme/_coenzyme1.93494686
20MP0002118_abnormal_lipid_homeostasis1.90221158
21MP0000003_abnormal_adipose_tissue1.89727919
22MP0002089_abnormal_postnatal_growth/wei1.89426248
23MP0000751_myopathy1.87586154
24MP0000733_abnormal_muscle_development1.86405579
25MP0001348_abnormal_lacrimal_gland1.85688869
26MP0001958_emphysema1.81308647
27MP0004381_abnormal_hair_follicle1.80383699
28MP0002138_abnormal_hepatobiliary_system1.79874426
29MP0001873_stomach_inflammation1.73654164
30MP0000678_abnormal_parathyroid_gland1.72196002
31MP0004019_abnormal_vitamin_homeostasis1.70625601
32MP0003705_abnormal_hypodermis_morpholog1.63562696
33MP0004858_abnormal_nervous_system1.62736590
34MP0002249_abnormal_larynx_morphology1.62314124
35MP0003656_abnormal_erythrocyte_physiolo1.59837173
36MP0009780_abnormal_chondrocyte_physiolo1.58390260
37MP0008961_abnormal_basal_metabolism1.57599984
38MP0003186_abnormal_redox_activity1.55162768
39MP0005584_abnormal_enzyme/coenzyme_acti1.54176706
40MP0005670_abnormal_white_adipose1.52875195
41MP0009643_abnormal_urine_homeostasis1.50974184
42MP0004264_abnormal_extraembryonic_tissu1.50637753
43MP0001849_ear_inflammation1.49780386
44MP0000767_abnormal_smooth_muscle1.46131702
45MP0001764_abnormal_homeostasis1.44213203
46MP0008438_abnormal_cutaneous_collagen1.42777635
47MP0002837_dystrophic_cardiac_calcinosis1.39944519
48MP0003279_aneurysm1.39850295
49MP0003868_abnormal_feces_composition1.39322128
50MP0003091_abnormal_cell_migration1.38290763
51MP0005451_abnormal_body_composition1.37775867
52MP0004130_abnormal_muscle_cell1.37582325
53MP0006036_abnormal_mitochondrial_physio1.35450097
54MP0000534_abnormal_ureter_morphology1.33597330
55MP0004272_abnormal_basement_membrane1.30052766
56MP0003942_abnormal_urinary_system1.27987968
57MP0000598_abnormal_liver_morphology1.27257462
58MP0002396_abnormal_hematopoietic_system1.24407881
59MP0002108_abnormal_muscle_morphology1.23140649
60MP0005257_abnormal_intraocular_pressure1.22967024
61MP0004145_abnormal_muscle_electrophysio1.22086410
62MP0009053_abnormal_anal_canal1.21795694
63MP0000759_abnormal_skeletal_muscle1.18873095
64MP0000013_abnormal_adipose_tissue1.16178092
65MP0003011_delayed_dark_adaptation1.15635697
66MP0000747_muscle_weakness1.15573916
67MP0002896_abnormal_bone_mineralization1.07978719
68MP0009763_increased_sensitivity_to1.06777203
69MP0009697_abnormal_copulation1.06536561
70* MP0008469_abnormal_protein_level1.05002639
71MP0009764_decreased_sensitivity_to1.04701651
72MP0010368_abnormal_lymphatic_system1.04481597
73MP0004134_abnormal_chest_morphology1.03988822
74MP0003045_fibrosis1.03704969
75MP0005666_abnormal_adipose_tissue1.03418866
76MP0005503_abnormal_tendon_morphology1.03072663
77MP0001879_abnormal_lymphatic_vessel1.02536411
78MP0002106_abnormal_muscle_physiology0.99234007
79MP0005058_abnormal_lysosome_morphology0.99189346
80MP0003453_abnormal_keratinocyte_physiol0.98370653
81MP0003879_abnormal_hair_cell0.96483866
82MP0000750_abnormal_muscle_regeneration0.94710989
83MP0002932_abnormal_joint_morphology0.94464178
84MP0005330_cardiomyopathy0.93343654
85MP0004147_increased_porphyrin_level0.93059118
86MP0004043_abnormal_pH_regulation0.92839791
87MP0002971_abnormal_brown_adipose0.92615788
88MP0005369_muscle_phenotype0.92601729
89MP0003646_muscle_fatigue0.92250025
90MP0005636_abnormal_mineral_homeostasis0.91722668
91MP0002098_abnormal_vibrissa_morphology0.90183763
92MP0001765_abnormal_ion_homeostasis0.89502916
93MP0002925_abnormal_cardiovascular_devel0.89210542
94MP0003172_abnormal_lysosome_physiology0.88672678
95MP0000383_abnormal_hair_follicle0.87752834
96MP0003436_decreased_susceptibility_to0.86303134
97MP0000537_abnormal_urethra_morphology0.85647337
98MP0002933_joint_inflammation0.85139557
99* MP0009642_abnormal_blood_homeostasis0.84901896
100MP0001756_abnormal_urination0.84451622
101MP0004947_skin_inflammation0.83669749
102MP0002269_muscular_atrophy0.83346473
103MP0001853_heart_inflammation0.83240448
104MP0000371_diluted_coat_color0.83110111
105MP0002877_abnormal_melanocyte_morpholog0.83107325
106MP0000604_amyloidosis0.83010104
107MP0005266_abnormal_metabolism0.82555162
108MP0000467_abnormal_esophagus_morphology0.81804556
109MP0004084_abnormal_cardiac_muscle0.81423058
110MP0005334_abnormal_fat_pad0.81033496
111MP0002128_abnormal_blood_circulation0.80740489
112MP0002009_preneoplasia0.80617915
113MP0003283_abnormal_digestive_organ0.80450525
114MP0005376_homeostasis/metabolism_phenot0.80376922
115MP0003724_increased_susceptibility_to0.80255212
116MP0005464_abnormal_platelet_physiology0.79472214
117MP0002078_abnormal_glucose_homeostasis0.78794952
118MP0003959_abnormal_lean_body0.78162145
119MP0005647_abnormal_sex_gland0.77943797
120MP0002254_reproductive_system_inflammat0.76308096
121MP0002116_abnormal_craniofacial_bone0.76294480
122MP0006035_abnormal_mitochondrial_morpho0.76116061
123MP0003115_abnormal_respiratory_system0.74809094
124MP0000266_abnormal_heart_morphology0.74663662
125MP0001664_abnormal_digestion0.73826594
126MP0002075_abnormal_coat/hair_pigmentati0.73796720
127MP0002160_abnormal_reproductive_system0.73008223
128MP0005220_abnormal_exocrine_pancreas0.72998924
129MP0000470_abnormal_stomach_morphology0.72187633
130MP0000428_abnormal_craniofacial_morphol0.71096729
131MP0002136_abnormal_kidney_physiology0.70412191
132MP0005084_abnormal_gallbladder_morpholo0.70398136
133MP0003300_gastrointestinal_ulcer0.70379823
134MP0005408_hypopigmentation0.70102980
135MP0002132_abnormal_respiratory_system0.66438542
136MP0004036_abnormal_muscle_relaxation0.65514347
137MP0003221_abnormal_cardiomyocyte_apopto0.65419563
138MP0000749_muscle_degeneration0.60116567
139MP0009115_abnormal_fat_cell0.60116463
140MP0010630_abnormal_cardiac_muscle0.59081476
141MP0009765_abnormal_xenobiotic_induced0.59021837
142MP0002970_abnormal_white_adipose0.58591935
143MP0000343_altered_response_to0.58487324
144MP0001544_abnormal_cardiovascular_syste0.58171457
145MP0005385_cardiovascular_system_phenoty0.58171457
146MP0004087_abnormal_muscle_fiber0.57510489
147MP0001835_abnormal_antigen_presentation0.56775222
148MP0004185_abnormal_adipocyte_glucose0.56592367
149MP0001845_abnormal_inflammatory_respons0.55580991
150MP0001661_extended_life_span0.54532398
151MP0005375_adipose_tissue_phenotype0.52965488
152MP0008775_abnormal_heart_ventricle0.51245945
153MP0005023_abnormal_wound_healing0.51196524
154MP0008873_increased_physiological_sensi0.50460810
155MP0006082_CNS_inflammation0.50145679
156MP0005535_abnormal_body_temperature0.49986015
157MP0004782_abnormal_surfactant_physiolog0.49463826
158MP0006138_congestive_heart_failure0.48600862
159MP0009785_altered_susceptibility_to0.48129445
160MP0002928_abnormal_bile_duct0.47873666
161MP0000249_abnormal_blood_vessel0.47704349
162MP0003690_abnormal_glial_cell0.46591262
163MP0009384_cardiac_valve_regurgitation0.46246721
164MP0000685_abnormal_immune_system0.45574251
165MP0003566_abnormal_cell_adhesion0.45115670
166MP0001243_abnormal_dermal_layer0.44946047
167MP0005448_abnormal_energy_balance0.44868934
168* MP0005025_abnormal_response_to0.44503944

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.92273711
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.88434525
3Deep venous thrombosis (HP:0002625)5.72449536
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.41717218
5Xanthomatosis (HP:0000991)5.30231652
6Hypobetalipoproteinemia (HP:0003563)5.00186633
7Prolonged partial thromboplastin time (HP:0003645)4.88268729
8Hyperammonemia (HP:0001987)4.53512256
9Complement deficiency (HP:0004431)4.47611156
10Hyperlipoproteinemia (HP:0010980)4.43906233
11Hyperglycinuria (HP:0003108)4.32297373
12Ketosis (HP:0001946)4.31241932
13Hypoglycemic coma (HP:0001325)4.26441292
14Hypolipoproteinemia (HP:0010981)4.08169701
15Abnormality of serine family amino acid metabolism (HP:0010894)4.06626442
16Abnormality of glycine metabolism (HP:0010895)4.06626442
17Abnormality of fatty-acid metabolism (HP:0004359)4.04808967
18Hyperglycinemia (HP:0002154)4.04579342
19Hypoalphalipoproteinemia (HP:0003233)3.80935207
20Joint hemorrhage (HP:0005261)3.78613500
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74151985
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.65658680
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65643304
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.64943037
25Abnormality of the common coagulation pathway (HP:0010990)3.64420645
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.56767705
27Epidermoid cyst (HP:0200040)3.47645449
28Fat malabsorption (HP:0002630)3.46276985
29Ketoacidosis (HP:0001993)3.43892103
30Abnormality of methionine metabolism (HP:0010901)3.39811979
31Abnormality of complement system (HP:0005339)3.33664989
32Abnormality of the intrinsic pathway (HP:0010989)3.25946743
33Hyperbilirubinemia (HP:0002904)3.23735972
34Dicarboxylic aciduria (HP:0003215)3.23242167
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23242167
36Broad face (HP:0000283)3.18346242
37Flat acetabular roof (HP:0003180)3.17611751
38Hypercholesterolemia (HP:0003124)3.14803016
39Abnormality of pyrimidine metabolism (HP:0004353)3.10139162
40Hyperacusis (HP:0010780)3.07593717
41Obstructive sleep apnea (HP:0002870)2.89154558
42Abnormality of nucleobase metabolism (HP:0010932)2.87818015
43Abnormality of the fingertips (HP:0001211)2.84876235
44Persistence of primary teeth (HP:0006335)2.84511015
45Metabolic acidosis (HP:0001942)2.83388953
46Protrusio acetabuli (HP:0003179)2.80730249
47Myoglobinuria (HP:0002913)2.79539660
48Abnormality of serum amino acid levels (HP:0003112)2.79496630
49Myocardial infarction (HP:0001658)2.78525033
50Generalized aminoaciduria (HP:0002909)2.77439036
51Abnormality of purine metabolism (HP:0004352)2.76657442
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74523909
53Steatorrhea (HP:0002570)2.72870804
54Genetic anticipation (HP:0003743)2.67951434
55Type 1 muscle fiber predominance (HP:0003803)2.67875183
56Systemic lupus erythematosus (HP:0002725)2.65378441
57Cholelithiasis (HP:0001081)2.64446298
58Gout (HP:0001997)2.62274647
59Lethargy (HP:0001254)2.62067392
60Abnormal gallbladder morphology (HP:0012437)2.61074144
61Ulnar bowing (HP:0003031)2.60677159
62Hepatocellular carcinoma (HP:0001402)2.60349789
63Thin bony cortex (HP:0002753)2.59504509
64Rhabdomyolysis (HP:0003201)2.57548720
65Dysmetric saccades (HP:0000641)2.56973769
66Rectal prolapse (HP:0002035)2.55507729
67Conjugated hyperbilirubinemia (HP:0002908)2.47626036
68Abnormality of the nasal septum (HP:0000419)2.45658128
69Skin nodule (HP:0200036)2.44684821
70Delayed CNS myelination (HP:0002188)2.43902428
71Hypochromic microcytic anemia (HP:0004840)2.40828419
72Aortic aneurysm (HP:0004942)2.40630849
73Asymmetry of the thorax (HP:0001555)2.39638069
74Cerebral aneurysm (HP:0004944)2.39517384
75Late onset (HP:0003584)2.36757375
76Cerebral edema (HP:0002181)2.36156858
77Acanthocytosis (HP:0001927)2.33580306
78Nausea (HP:0002018)2.31754725
79Cervical subluxation (HP:0003308)2.31669742
80Increased connective tissue (HP:0009025)2.31142060
81Ulnar deviation of the wrist (HP:0003049)2.29993294
82Bowing of the arm (HP:0006488)2.29726657
83Bowed forearm bones (HP:0003956)2.29726657
84Vomiting (HP:0002013)2.27206335
85Oligodontia (HP:0000677)2.26593044
86Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.23876549
87Hypoglycemic seizures (HP:0002173)2.22885041
88Proximal tubulopathy (HP:0000114)2.22576070
89Vascular calcification (HP:0004934)2.21911028
90Poikilocytosis (HP:0004447)2.20947974
91Abnormal gallbladder physiology (HP:0012438)2.20685779
92Cholecystitis (HP:0001082)2.20685779
93Shallow orbits (HP:0000586)2.20672307
94Tibial bowing (HP:0002982)2.20650784
95Radial bowing (HP:0002986)2.19267260
96Mitral stenosis (HP:0001718)2.18704820
97Esophageal varix (HP:0002040)2.18545017
98Dislocated radial head (HP:0003083)2.17676977
99Spastic diplegia (HP:0001264)2.16217094
100Malnutrition (HP:0004395)2.15305059
101Hyporeflexia of lower limbs (HP:0002600)2.15100562
102Recurrent gram-negative bacterial infections (HP:0005420)2.14475491
103Pancreatitis (HP:0001733)2.14130049
104Short femoral neck (HP:0100864)2.14088629
105Exercise-induced myalgia (HP:0003738)2.12822640
106Lip pit (HP:0100267)2.11362667
107Abnormality of the distal phalanx of the thumb (HP:0009617)2.10945226
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09560561
109Short 4th metacarpal (HP:0010044)2.09560561
110Macroorchidism (HP:0000053)2.09248158
111Clumsiness (HP:0002312)2.07555193
112Abnormality of the radial head (HP:0003995)2.06429767
113Mildly elevated creatine phosphokinase (HP:0008180)2.06303033
114Gingival bleeding (HP:0000225)2.05624183
115Abnormality of iron homeostasis (HP:0011031)2.05066343
116Glomerulonephritis (HP:0000099)2.04398941
117Lymphangioma (HP:0100764)2.04335614
118Advanced eruption of teeth (HP:0006288)2.03697776
119Aneurysm (HP:0002617)2.03065691
120Hyperinsulinemic hypoglycemia (HP:0000825)2.02232141
121Menorrhagia (HP:0000132)2.01867895
122Asymmetric septal hypertrophy (HP:0001670)2.01183671
123Renal cortical cysts (HP:0000803)2.00674625
124Cardiovascular calcification (HP:0011915)1.99727139
125Abnormality of the gallbladder (HP:0005264)1.99464461
126Abnormality of transition element cation homeostasis (HP:0011030)1.99341845
127Polycythemia (HP:0001901)1.99042481
128Sensorimotor neuropathy (HP:0007141)1.98853684
129Spontaneous abortion (HP:0005268)1.97283431
130Neonatal onset (HP:0003623)1.97115256
131Aplasia/hypoplasia of the femur (HP:0005613)1.97001066
132Abnormal cartilage morphology (HP:0002763)1.95576046
133Hemorrhage of the eye (HP:0011885)1.94258329
134Hydroxyprolinuria (HP:0003080)1.94162301
135Abnormality of proline metabolism (HP:0010907)1.94162301
136Distal lower limb amyotrophy (HP:0008944)1.93859354
137Reticulocytosis (HP:0001923)1.93701745
138Irritability (HP:0000737)1.93677559
139Hypertriglyceridemia (HP:0002155)1.91527196
140Abnormal ossification of hand bones (HP:0005921)1.91164985
141Right ventricular cardiomyopathy (HP:0011663)1.89232045
142Disproportionate tall stature (HP:0001519)1.88444157
143Opisthotonus (HP:0002179)1.88338426
144Thrombophlebitis (HP:0004418)1.87717572
145Hyperglycemia (HP:0003074)1.87234321
146Increased purine levels (HP:0004368)1.87001720
147Hyperuricemia (HP:0002149)1.87001720
148Bronchomalacia (HP:0002780)1.86927368
149Elevated hepatic transaminases (HP:0002910)1.86548986
150Axonal loss (HP:0003447)1.86173775
151Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.82061587
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.81433019
153Spinal rigidity (HP:0003306)1.81260292
154Neonatal hypoglycemia (HP:0001998)1.80944254
155Distal lower limb muscle weakness (HP:0009053)1.80855460
156Scapular winging (HP:0003691)1.80007276
157Abnormality of the right ventricle (HP:0001707)1.79470885
158Increased variability in muscle fiber diameter (HP:0003557)1.77373724
159Abnormality of carpal bone ossification (HP:0006257)1.76558520
160Myopathic facies (HP:0002058)1.75722334
161Abnormality of the thoracic spine (HP:0100711)1.75377964
162Long eyelashes (HP:0000527)1.74049983
163Aortic regurgitation (HP:0001659)1.73605060
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.73436840
165Round ear (HP:0100830)1.73306921
166Coxa vara (HP:0002812)1.73055480
167Cupped ribs (HP:0000887)1.72796587
168Sparse lateral eyebrow (HP:0005338)1.68799754
169Mitral regurgitation (HP:0001653)1.68696687
170Fragile skin (HP:0001030)1.64048284
171Renovascular hypertension (HP:0100817)1.64036419
172Broad metatarsal (HP:0001783)1.63876181
173Ventricular tachycardia (HP:0004756)1.63712296
174Germ cell neoplasia (HP:0100728)1.61887453
175Arterial tortuosity (HP:0005116)1.61024464
176Decreased circulating renin level (HP:0003351)1.61017072
177Aortic dissection (HP:0002647)1.60974959
178Narrow palate (HP:0000189)1.60691240
179Hamartoma of the eye (HP:0010568)1.59302255
180Joint laxity (HP:0001388)1.59033467
181Hyperkalemia (HP:0002153)1.58297979
182Blue sclerae (HP:0000592)1.57862134
183Bladder diverticulum (HP:0000015)1.57560797
184Heterotopia (HP:0002282)1.55266239
185Overgrowth (HP:0001548)1.55255303
186Abnormality of skeletal muscle fiber size (HP:0012084)1.52456196
187Preauricular pit (HP:0004467)1.52022496
188Periauricular skin pits (HP:0100277)1.52022496
189Abnormality of the odontoid process (HP:0003310)1.51463125
190Ovoid vertebral bodies (HP:0003300)1.50221777
191Bundle branch block (HP:0011710)1.49039463
192J-shaped sella turcica (HP:0002680)1.48435245
193Vascular tortuosity (HP:0004948)1.48226317
194Abnormality of the 4th metacarpal (HP:0010012)1.47999383
195Natal tooth (HP:0000695)1.47981129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.61953246
2ERN14.47171461
3SIK13.16192890
4CDK123.11692437
5PKN23.04099147
6TRIB32.95302071
7SMG12.65133587
8FGFR42.59510977
9FLT32.31078928
10TTN2.13670446
11EPHA22.08904844
12TYK21.99353819
13MAP2K31.97245208
14PIK3CG1.96519728
15TAOK31.93749221
16KDR1.84101886
17PRKD21.76579422
18TGFBR21.62674800
19CDC42BPA1.61506783
20MAPK111.59908864
21OBSCN1.58608866
22TIE11.56863262
23MAP4K11.56769568
24MAP3K31.54955461
25AKT31.48338124
26MAP3K101.48219781
27NEK91.43417483
28TBK11.38555830
29INSRR1.32989414
30MARK21.31770843
31PTK61.28775913
32RPS6KA21.27742065
33IRAK31.26164810
34PRPF4B1.24578337
35LATS11.22722946
36MAP3K71.21931174
37ERBB41.20983625
38SIK21.14684911
39JAK11.14297700
40HIPK21.12920293
41MYLK1.12134156
42PINK11.11193979
43PDK41.06956066
44PDK31.06956066
45CAMK1G1.06841085
46PRKAA21.05171411
47MST1R1.04226415
48MAP3K111.04036425
49STK101.02388738
50JAK21.01253731
51NME20.99565310
52STK380.99232225
53RPS6KB20.98892769
54RPS6KA60.98140195
55PDPK10.96596116
56PDGFRB0.95873716
57WNK10.95690347
58RPS6KC10.95577637
59RPS6KL10.95577637
60JAK30.95424155
61MELK0.95154455
62CAMK1D0.94182547
63CDK40.93062974
64KIT0.92662928
65RET0.91816807
66EPHB10.90533792
67WNK40.88022466
68PTK20.86488325
69CSF1R0.85495933
70MAP3K140.83357681
71LRRK20.82974164
72ABL20.81926177
73STK40.80850866
74GRK60.80122364
75CDK60.79804536
76MAP2K20.78463362
77NEK10.77940410
78TYRO30.77598125
79ZAP700.77393900
80BLK0.76083500
81RIPK10.74823013
82PHKG10.73001735
83PHKG20.73001735
84PIK3CA0.72490473
85SGK20.72163181
86DDR20.72092807
87PRKAA10.72000474
88PIM10.69821817
89TGFBR10.69538177
90EEF2K0.69145883
91PDK20.64189661
92MAPK120.63132149
93DMPK0.61610347
94DYRK1B0.61418613
95MAP3K60.60655835
96SGK4940.60610664
97SGK2230.60610664
98IKBKE0.60595267
99STK30.60500945
100TAOK20.59998528
101CSK0.58341685
102TNK20.56825210
103BTK0.55434249
104MET0.54940880
105MAPK150.54492336
106BMX0.54342763
107PDK10.53910871
108TLK10.52072841
109MAPK40.50628249
110PIM20.50516814
111LMTK20.50068939
112STK38L0.48524626
113NEK20.48229705
114MAP3K50.48119717
115RPS6KA40.47996180
116MTOR0.47678991
117MAP2K10.47330063
118MAPKAPK30.47175275
119MAP3K130.45850782
120ITK0.45652794
121GSK3A0.44767200
122IKBKB0.43289543
123MUSK0.42610769
124MAP3K80.42485883
125ERBB20.41885894
126MAP2K60.41732901
127PRKACG0.41677438
128PRKD30.41090381
129CDK90.41064711
130NLK0.40494278
131MAPKAPK20.39429842
132FGFR20.39072027
133MAPK70.38500497
134CHUK0.37602745
135FRK0.36976646
136SGK30.36874786
137PRKD10.36553723
138MAPK30.34214072
139CDK70.34016854
140RPS6KB10.33668581
141FGFR30.33328436
142MAPK80.33309116
143PAK20.32776190
144TEC0.32606741
145AKT10.31685590
146PRKG20.29949131
147PRKCH0.29640229
148PDGFRA0.29134572
149ICK0.28553406
150TRPM70.26010179

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83780774
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16952052
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05258881
4Fatty acid degradation_Homo sapiens_hsa000712.96839539
5Nitrogen metabolism_Homo sapiens_hsa009102.80214250
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72039944
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68066644
8Arginine biosynthesis_Homo sapiens_hsa002202.58170034
9Tryptophan metabolism_Homo sapiens_hsa003802.53352238
10Propanoate metabolism_Homo sapiens_hsa006402.40912311
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40146577
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39036546
13Complement and coagulation cascades_Homo sapiens_hsa046102.37589543
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27185785
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22371775
16Fatty acid metabolism_Homo sapiens_hsa012122.16190809
17Peroxisome_Homo sapiens_hsa041462.10006978
18PPAR signaling pathway_Homo sapiens_hsa033201.99737662
19Caffeine metabolism_Homo sapiens_hsa002321.96920525
20Butanoate metabolism_Homo sapiens_hsa006501.95289916
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83094049
22Notch signaling pathway_Homo sapiens_hsa043301.79549328
23beta-Alanine metabolism_Homo sapiens_hsa004101.76252937
24Chemical carcinogenesis_Homo sapiens_hsa052041.68769407
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66735660
26Histidine metabolism_Homo sapiens_hsa003401.65389564
27Pyruvate metabolism_Homo sapiens_hsa006201.64706521
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.64550285
29Staphylococcus aureus infection_Homo sapiens_hsa051501.62260941
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60627991
31Carbon metabolism_Homo sapiens_hsa012001.60088579
32Chronic myeloid leukemia_Homo sapiens_hsa052201.57739050
33Selenocompound metabolism_Homo sapiens_hsa004501.55107977
34Non-small cell lung cancer_Homo sapiens_hsa052231.55097510
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54773694
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53757222
37ECM-receptor interaction_Homo sapiens_hsa045121.51810546
38Starch and sucrose metabolism_Homo sapiens_hsa005001.45475929
39mTOR signaling pathway_Homo sapiens_hsa041501.44897405
40VEGF signaling pathway_Homo sapiens_hsa043701.43704495
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.43576368
42Folate biosynthesis_Homo sapiens_hsa007901.42340129
43Biosynthesis of amino acids_Homo sapiens_hsa012301.41839757
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.41214789
45Focal adhesion_Homo sapiens_hsa045101.37518876
46Phenylalanine metabolism_Homo sapiens_hsa003601.37364998
47Retinol metabolism_Homo sapiens_hsa008301.37095992
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36215541
49Sulfur metabolism_Homo sapiens_hsa009201.34413016
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32482063
51Dilated cardiomyopathy_Homo sapiens_hsa054141.32474089
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32340423
53Fatty acid elongation_Homo sapiens_hsa000621.31507438
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.30167130
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26264226
56Bladder cancer_Homo sapiens_hsa052191.26130779
57Sulfur relay system_Homo sapiens_hsa041221.26078550
58Choline metabolism in cancer_Homo sapiens_hsa052311.23041888
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22880454
60Bile secretion_Homo sapiens_hsa049761.22739687
61Endometrial cancer_Homo sapiens_hsa052131.21441894
62Fat digestion and absorption_Homo sapiens_hsa049751.21384028
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21020264
64Tyrosine metabolism_Homo sapiens_hsa003501.18887756
65Phospholipase D signaling pathway_Homo sapiens_hsa040721.18396460
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17541983
67ABC transporters_Homo sapiens_hsa020101.14292085
68Pancreatic cancer_Homo sapiens_hsa052121.14258649
69Small cell lung cancer_Homo sapiens_hsa052221.13684648
70Renal cell carcinoma_Homo sapiens_hsa052111.13500150
71Glioma_Homo sapiens_hsa052141.11804476
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11741175
73Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11617005
74Platelet activation_Homo sapiens_hsa046111.07942414
75Melanoma_Homo sapiens_hsa052181.07003328
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06330039
77MicroRNAs in cancer_Homo sapiens_hsa052061.03368536
78Arginine and proline metabolism_Homo sapiens_hsa003301.02443714
79Prostate cancer_Homo sapiens_hsa052151.02254679
80Cyanoamino acid metabolism_Homo sapiens_hsa004601.01815817
81ErbB signaling pathway_Homo sapiens_hsa040120.99551766
82Proteoglycans in cancer_Homo sapiens_hsa052050.97945017
83GnRH signaling pathway_Homo sapiens_hsa049120.97928824
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97475128
85Prolactin signaling pathway_Homo sapiens_hsa049170.95884895
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95857273
87Lysine degradation_Homo sapiens_hsa003100.95646500
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94027412
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.93824907
90One carbon pool by folate_Homo sapiens_hsa006700.92092017
91Estrogen signaling pathway_Homo sapiens_hsa049150.91962638
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91369757
93Vitamin digestion and absorption_Homo sapiens_hsa049770.91332584
94Pentose phosphate pathway_Homo sapiens_hsa000300.89955263
95Thyroid cancer_Homo sapiens_hsa052160.89538181
96Steroid biosynthesis_Homo sapiens_hsa001000.89369500
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.88663900
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.85128316
99B cell receptor signaling pathway_Homo sapiens_hsa046620.83176906
100Glutathione metabolism_Homo sapiens_hsa004800.83067418
101FoxO signaling pathway_Homo sapiens_hsa040680.81886848
102Dorso-ventral axis formation_Homo sapiens_hsa043200.81831903
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81324177
104Inositol phosphate metabolism_Homo sapiens_hsa005620.81245524
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80381101
106Vitamin B6 metabolism_Homo sapiens_hsa007500.79370871
107Adherens junction_Homo sapiens_hsa045200.79157813
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78663542
109Type II diabetes mellitus_Homo sapiens_hsa049300.78290335
110Glycerolipid metabolism_Homo sapiens_hsa005610.77113003
111MAPK signaling pathway_Homo sapiens_hsa040100.75000058
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74648660
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72322951
114Fatty acid biosynthesis_Homo sapiens_hsa000610.69789472
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69067728
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.68866810
117Ovarian steroidogenesis_Homo sapiens_hsa049130.68134508
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66659114
119Pathways in cancer_Homo sapiens_hsa052000.64641138
120Gastric acid secretion_Homo sapiens_hsa049710.63637839
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63187022
122Cholinergic synapse_Homo sapiens_hsa047250.61423355
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61259379
124Thyroid hormone synthesis_Homo sapiens_hsa049180.61080145
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60124269
126Amoebiasis_Homo sapiens_hsa051460.59868499
127Galactose metabolism_Homo sapiens_hsa000520.58888627
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58775279
129Rap1 signaling pathway_Homo sapiens_hsa040150.58414107
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57602615
131Oxytocin signaling pathway_Homo sapiens_hsa049210.57186807
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57027882
133TNF signaling pathway_Homo sapiens_hsa046680.55249234
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54172320
135Basal cell carcinoma_Homo sapiens_hsa052170.53250146
136Renin secretion_Homo sapiens_hsa049240.53053195
137Hippo signaling pathway_Homo sapiens_hsa043900.50997956
138Metabolic pathways_Homo sapiens_hsa011000.50171629
139Calcium signaling pathway_Homo sapiens_hsa040200.49870634
140Melanogenesis_Homo sapiens_hsa049160.49525006
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48352988
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.47319742
143Insulin resistance_Homo sapiens_hsa049310.45523251
144Fructose and mannose metabolism_Homo sapiens_hsa000510.44817474
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43787851
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22701276
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22273964
148AMPK signaling pathway_Homo sapiens_hsa041520.19107228
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18787474
150Prion diseases_Homo sapiens_hsa050200.14133517
151Glucagon signaling pathway_Homo sapiens_hsa049220.13326903
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.12511070
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.08011096
154Linoleic acid metabolism_Homo sapiens_hsa005910.08005758
155Legionellosis_Homo sapiens_hsa051340.05681762
156Other glycan degradation_Homo sapiens_hsa005110.05389811
157Renin-angiotensin system_Homo sapiens_hsa046140.05178313
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03779070
159Insulin signaling pathway_Homo sapiens_hsa049100.02977141
160Lysosome_Homo sapiens_hsa041420.01509266
161Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1581656
162Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1574222
163Protein digestion and absorption_Homo sapiens_hsa04974-0.1564315
164Pertussis_Homo sapiens_hsa05133-0.1555226
165Acute myeloid leukemia_Homo sapiens_hsa05221-0.1440344
166Malaria_Homo sapiens_hsa05144-0.1430300
167* Hepatitis C_Homo sapiens_hsa05160-0.1294157
168Pyrimidine metabolism_Homo sapiens_hsa00240-0.1194262
169Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1128404
170Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0742865
171Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0643164
172Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0585513
173Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0201200

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