MAST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.50166985
2sarcomere organization (GO:0045214)5.11048525
3cardiac myofibril assembly (GO:0055003)5.00154129
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.76708570
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.61891996
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.53501186
7cell communication by electrical coupling (GO:0010644)4.27237075
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.19277600
9myofibril assembly (GO:0030239)4.17063408
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.04481021
11cardiac muscle contraction (GO:0060048)3.87543199
12cell communication involved in cardiac conduction (GO:0086065)3.85151871
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.74911099
14regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.71991143
15actomyosin structure organization (GO:0031032)3.70469966
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.67201882
17skeletal muscle contraction (GO:0003009)3.56591652
18actin-myosin filament sliding (GO:0033275)3.54598307
19muscle filament sliding (GO:0030049)3.54598307
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.53868655
21ventricular cardiac muscle cell action potential (GO:0086005)3.52023101
22cardiac muscle cell development (GO:0055013)3.50596034
23sodium ion export (GO:0071436)3.43652434
24regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.41847896
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.39601729
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37977164
27actin filament depolymerization (GO:0030042)3.33706034
28cardiac cell development (GO:0055006)3.30307671
29negative regulation of cell size (GO:0045792)3.25089042
30regulation of membrane repolarization (GO:0060306)3.25037106
31semaphorin-plexin signaling pathway (GO:0071526)3.22633936
32regulation of skeletal muscle contraction (GO:0014819)3.20390246
33regulation of NFAT protein import into nucleus (GO:0051532)3.19213545
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.13293536
35peptidyl-lysine dimethylation (GO:0018027)3.13097038
36striated muscle contraction (GO:0006941)3.12793503
37layer formation in cerebral cortex (GO:0021819)3.10136064
38epithelial cell-cell adhesion (GO:0090136)3.09719850
39NADH metabolic process (GO:0006734)3.08377514
40cell-substrate junction assembly (GO:0007044)3.07028311
41actin-mediated cell contraction (GO:0070252)3.05090008
42cardiac muscle hypertrophy (GO:0003300)2.99489514
43establishment of nucleus localization (GO:0040023)2.99213369
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97972372
45positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.97131741
46carnitine shuttle (GO:0006853)2.94794879
47regulation of actin filament-based movement (GO:1903115)2.93643463
48sarcoplasmic reticulum calcium ion transport (GO:0070296)2.91934052
49regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89189306
50striated muscle hypertrophy (GO:0014897)2.87447621
51synaptic vesicle docking involved in exocytosis (GO:0016081)2.86838527
52tricarboxylic acid cycle (GO:0006099)2.85685006
53actin filament-based movement (GO:0030048)2.83913963
54adult heart development (GO:0007512)2.83308519
55positive regulation of myotube differentiation (GO:0010831)2.81881182
56creatine metabolic process (GO:0006600)2.79203689
57growth hormone secretion (GO:0030252)2.78256030
58insulin-like growth factor receptor signaling pathway (GO:0048009)2.77324678
59regulation of synapse structural plasticity (GO:0051823)2.76423595
60negative regulation of organelle assembly (GO:1902116)2.76423556
61activation of protein kinase A activity (GO:0034199)2.75191500
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74314595
63regulation of calcium ion transmembrane transport (GO:1903169)2.74218023
64regulation of calcium ion transmembrane transporter activity (GO:1901019)2.74218023
65negative regulation of potassium ion transport (GO:0043267)2.74151825
66cardiac conduction (GO:0061337)2.72838551
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72558076
68cardiac muscle cell action potential (GO:0086001)2.71600561
69cardiac muscle cell action potential involved in contraction (GO:0086002)2.71453564
70COPI coating of Golgi vesicle (GO:0048205)2.69908017
71Golgi transport vesicle coating (GO:0048200)2.69908017
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69253937
73muscle contraction (GO:0006936)2.69125349
74synaptic vesicle maturation (GO:0016188)2.68809143
75negative regulation of fatty acid transport (GO:2000192)2.68628118
76locomotory exploration behavior (GO:0035641)2.68597932
77NLS-bearing protein import into nucleus (GO:0006607)2.67737003
78regulation of hippo signaling (GO:0035330)2.67581261
79stress fiber assembly (GO:0043149)2.67551057
80striated muscle atrophy (GO:0014891)2.66356383
81myoblast fusion (GO:0007520)2.65786031
82cell-cell junction maintenance (GO:0045217)2.65576852
83adherens junction assembly (GO:0034333)2.65259083
84regulation of the force of heart contraction (GO:0002026)2.62939714
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62703355
86protein retention in ER lumen (GO:0006621)2.62081476
87membrane repolarization during action potential (GO:0086011)2.61415820
88potassium ion import (GO:0010107)2.61109095
89membrane repolarization (GO:0086009)2.60881195
90basement membrane organization (GO:0071711)2.59404912
91regulation of tight junction assembly (GO:2000810)2.59163884
92syncytium formation by plasma membrane fusion (GO:0000768)2.58730061
93heart trabecula formation (GO:0060347)2.58642045
94response to inactivity (GO:0014854)2.58575387
95regulation of heart rate by cardiac conduction (GO:0086091)2.58472878
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.56641525
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55786849
98cellular potassium ion homeostasis (GO:0030007)2.53922826
99endothelial cell chemotaxis (GO:0035767)2.53637411
100nucleus localization (GO:0051647)2.53128324
101striated muscle adaptation (GO:0014888)2.52668511
102relaxation of cardiac muscle (GO:0055119)2.51377545
103positive regulation of sodium ion transport (GO:0010765)2.49859185
104negative regulation of catenin import into nucleus (GO:0035414)2.49610268
105regulation of cell communication by electrical coupling (GO:0010649)2.47938114
106regulation of p38MAPK cascade (GO:1900744)2.47163131
107atrioventricular valve morphogenesis (GO:0003181)2.46834228
108cytoplasmic mRNA processing body assembly (GO:0033962)2.46519995
109vocalization behavior (GO:0071625)2.46290494
110skeletal muscle fiber development (GO:0048741)2.46232549
111cochlea morphogenesis (GO:0090103)2.46197033
112maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46184887
113skeletal muscle adaptation (GO:0043501)2.45911890
114regulation of clathrin-mediated endocytosis (GO:2000369)2.44886446
115glial cell proliferation (GO:0014009)2.43259891
116skin morphogenesis (GO:0043589)2.43180998
117regulation of striated muscle contraction (GO:0006942)2.42628952
118positive regulation of synapse maturation (GO:0090129)2.42505140
119regulation of relaxation of muscle (GO:1901077)2.41941862
120desmosome organization (GO:0002934)2.41753573
121hemidesmosome assembly (GO:0031581)2.41657980
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.41628641
123carnitine transmembrane transport (GO:1902603)2.40020443
124protein targeting to plasma membrane (GO:0072661)2.39070757
125cardiac muscle hypertrophy in response to stress (GO:0014898)2.38613142
126muscle hypertrophy in response to stress (GO:0003299)2.38613142
127cardiac muscle adaptation (GO:0014887)2.38613142
128positive regulation of cation channel activity (GO:2001259)2.38547374
129regulation of cardioblast differentiation (GO:0051890)2.37564604
130regulation of potassium ion transmembrane transporter activity (GO:1901016)2.37049235
131muscle hypertrophy (GO:0014896)2.36967235
132muscle system process (GO:0003012)2.36935184
133regulation of early endosome to late endosome transport (GO:2000641)2.36413817
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.36173990
135focal adhesion assembly (GO:0048041)2.36079924
136cell-substrate adherens junction assembly (GO:0007045)2.36079924
137muscle tissue morphogenesis (GO:0060415)2.35561955
138protein heterotrimerization (GO:0070208)2.35338674
139barbed-end actin filament capping (GO:0051016)2.33933130
140muscle organ development (GO:0007517)2.33295579
141regulation of fatty acid beta-oxidation (GO:0031998)2.32909033
142kidney mesenchyme development (GO:0072074)2.32580100
143bone trabecula formation (GO:0060346)2.32025457
144regulation of ARF GTPase activity (GO:0032312)2.31919477
145muscle structure development (GO:0061061)2.29236222
146metanephric mesenchyme development (GO:0072075)2.28715422
147apoptotic process involved in morphogenesis (GO:0060561)2.28660103
148response to muscle activity (GO:0014850)2.28348288
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.28158395
150muscle atrophy (GO:0014889)2.26727472
151cell junction maintenance (GO:0034331)2.25536878
152regulation of fatty acid oxidation (GO:0046320)2.24853623
153cardiac muscle tissue morphogenesis (GO:0055008)2.23444031
154mannose metabolic process (GO:0006013)2.23322099
155skeletal muscle tissue development (GO:0007519)2.23188823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.96562081
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.79896510
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.63175697
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48736516
5ZNF263_19887448_ChIP-Seq_K562_Human2.38792524
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37445290
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18406203
8DROSHA_22980978_ChIP-Seq_HELA_Human2.11288663
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11254563
10KDM2B_26808549_Chip-Seq_K562_Human2.08981982
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.06972091
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04596456
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99934740
14KDM2B_26808549_Chip-Seq_DND41_Human1.94865570
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86470210
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.85002357
17TBX20_22080862_ChIP-Seq_HEART_Mouse1.84174056
18TBX20_22328084_ChIP-Seq_HEART_Mouse1.84174056
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82334459
20* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76045525
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.75017590
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74119576
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74012343
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67836752
25ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67600864
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.60860905
27* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57474050
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53307786
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52591759
30LXR_22292898_ChIP-Seq_THP-1_Human1.51251727
31* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50582412
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.48021085
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.47569947
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47287962
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47164871
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44410018
37* CREB1_26743006_Chip-Seq_LNCaP_Human1.42223557
38TCF7_22412390_ChIP-Seq_EML_Mouse1.40694083
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40626870
40VDR_21846776_ChIP-Seq_THP-1_Human1.40059186
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.39556441
42* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38322661
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.37386035
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36745299
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35931092
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32088898
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.31510935
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27919563
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27919563
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27494953
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.26355399
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26219291
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26068096
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25661379
55ATF3_27146783_Chip-Seq_COLON_Human1.25417122
56* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25002372
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24932570
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24199085
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.23497874
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23491535
61* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23268736
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22295124
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21781793
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21734984
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20087049
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20076921
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.19591006
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.19056504
69TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18961010
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18260687
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17482666
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17022161
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16926292
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16871331
75* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14875786
76* SMC4_20622854_ChIP-Seq_HELA_Human1.13529724
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13475831
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13471452
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13224886
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.12468393
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.12452448
82CTCF_27219007_Chip-Seq_Bcells_Human1.12066597
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11926283
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11252223
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10714288
86AR_19668381_ChIP-Seq_PC3_Human1.09402292
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.08913632
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.08340757
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08250370
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.07488294
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06899763
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.05600987
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05035646
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04597107
95* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04509721
96MYC_22102868_ChIP-Seq_BL_Human1.04342737
97AHR_22903824_ChIP-Seq_MCF-7_Human1.03291764
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02340958
99* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00885701
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00691380
101P68_20966046_ChIP-Seq_HELA_Human1.00465793
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00333289
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00290797
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00223685
105TP63_22573176_ChIP-Seq_HFKS_Human0.99310740
106* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98908864
107* OCT4_19829295_ChIP-Seq_ESCs_Human0.98866723
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98707398
109ZNF274_21170338_ChIP-Seq_K562_Hela0.98517224
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98464159
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.98012193
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97823490
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97001358
114TP53_22127205_ChIP-Seq_IMR90_Human0.96495950
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95088045
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.94945677
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94350980
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93806991
119CLOCK_20551151_ChIP-Seq_293T_Human0.93684592
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.93631854
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92517696
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92127155
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.91929741
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91431775
125* TCF4_18268006_ChIP-ChIP_LS174T_Human0.91414926
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91150087
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90798918
128REST_21632747_ChIP-Seq_MESCs_Mouse0.90655372
129GATA1_19941826_ChIP-Seq_K562_Human0.90187430
130KLF4_19829295_ChIP-Seq_ESCs_Human0.89829498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.48252353
2MP0002837_dystrophic_cardiac_calcinosis4.14675073
3MP0003646_muscle_fatigue3.95544509
4MP0004084_abnormal_cardiac_muscle3.56902226
5MP0004215_abnormal_myocardial_fiber2.97690289
6MP0003705_abnormal_hypodermis_morpholog2.84815176
7MP0004233_abnormal_muscle_weight2.75486183
8MP0004087_abnormal_muscle_fiber2.62213024
9MP0004036_abnormal_muscle_relaxation2.60751745
10MP0000749_muscle_degeneration2.60146783
11MP0004859_abnormal_synaptic_plasticity2.46935480
12MP0005451_abnormal_body_composition2.45920340
13MP0005409_darkened_coat_color2.38641827
14MP0005330_cardiomyopathy2.31433337
15MP0000750_abnormal_muscle_regeneration2.28497796
16MP0003283_abnormal_digestive_organ2.23500038
17MP0004145_abnormal_muscle_electrophysio2.15122651
18MP0005623_abnormal_meninges_morphology2.03186351
19MP0005503_abnormal_tendon_morphology2.02800775
20MP0002269_muscular_atrophy1.98778234
21MP0009780_abnormal_chondrocyte_physiolo1.98273289
22MP0010630_abnormal_cardiac_muscle1.97645543
23MP0002106_abnormal_muscle_physiology1.91332633
24MP0000747_muscle_weakness1.89169451
25MP0003137_abnormal_impulse_conducting1.87244581
26MP0002972_abnormal_cardiac_muscle1.87237956
27MP0005620_abnormal_muscle_contractility1.86680415
28MP0004130_abnormal_muscle_cell1.84800352
29MP0005257_abnormal_intraocular_pressure1.84397099
30MP0000759_abnormal_skeletal_muscle1.75657816
31MP0008775_abnormal_heart_ventricle1.71738775
32MP0002249_abnormal_larynx_morphology1.66133691
33MP0008961_abnormal_basal_metabolism1.65253533
34MP0004484_altered_response_of1.64825422
35MP0002234_abnormal_pharynx_morphology1.64216727
36MP0009384_cardiac_valve_regurgitation1.63473416
37MP0006138_congestive_heart_failure1.60896997
38MP0005369_muscle_phenotype1.60189243
39MP0010030_abnormal_orbit_morphology1.60169020
40MP0001544_abnormal_cardiovascular_syste1.55350418
41MP0005385_cardiovascular_system_phenoty1.55350418
42MP0005076_abnormal_cell_differentiation1.55197066
43MP0004085_abnormal_heartbeat1.49320301
44MP0004858_abnormal_nervous_system1.49239934
45MP0000733_abnormal_muscle_development1.44633410
46MP0002909_abnormal_adrenal_gland1.44102349
47MP0010368_abnormal_lymphatic_system1.39732625
48MP0003566_abnormal_cell_adhesion1.34780983
49MP0010352_gastrointestinal_tract_polyps1.31740755
50MP0004510_myositis1.30737683
51MP0000569_abnormal_digit_pigmentation1.29063905
52MP0000678_abnormal_parathyroid_gland1.28673048
53MP0000462_abnormal_digestive_system1.26958006
54MP0005666_abnormal_adipose_tissue1.26034768
55MP0003045_fibrosis1.26033117
56MP0004270_analgesia1.24620258
57MP0004185_abnormal_adipocyte_glucose1.24541464
58MP0005187_abnormal_penis_morphology1.21825275
59MP0000537_abnormal_urethra_morphology1.18523127
60MP0002877_abnormal_melanocyte_morpholog1.17435541
61MP0001348_abnormal_lacrimal_gland1.16307192
62MP0000003_abnormal_adipose_tissue1.15786819
63MP0005670_abnormal_white_adipose1.14880980
64MP0005375_adipose_tissue_phenotype1.12932645
65MP0002653_abnormal_ependyma_morphology1.11100448
66MP0002108_abnormal_muscle_morphology1.11049089
67MP0001849_ear_inflammation1.08397709
68MP0003635_abnormal_synaptic_transmissio1.08004413
69MP0000266_abnormal_heart_morphology1.07196586
70MP0003221_abnormal_cardiomyocyte_apopto1.06121258
71MP0003300_gastrointestinal_ulcer1.04185208
72MP0000013_abnormal_adipose_tissue1.00848695
73MP0005058_abnormal_lysosome_morphology0.99624046
74MP0002332_abnormal_exercise_endurance0.97333672
75MP0005360_urolithiasis0.97151587
76MP0005377_hearing/vestibular/ear_phenot0.96904443
77MP0003878_abnormal_ear_physiology0.96904443
78MP0003279_aneurysm0.94280085
79MP0009840_abnormal_foam_cell0.92665852
80MP0010234_abnormal_vibrissa_follicle0.91869437
81MP0008438_abnormal_cutaneous_collagen0.91767454
82MP0000762_abnormal_tongue_morphology0.91580448
83MP0003942_abnormal_urinary_system0.91564528
84MP0005023_abnormal_wound_healing0.89052009
85MP0002127_abnormal_cardiovascular_syste0.86437845
86MP0003115_abnormal_respiratory_system0.86232675
87MP0001299_abnormal_eye_distance/0.86041546
88MP0003091_abnormal_cell_migration0.85073768
89MP0002060_abnormal_skin_morphology0.84012152
90MP0003385_abnormal_body_wall0.83051231
91MP0008260_abnormal_autophagy0.82195304
92MP0002114_abnormal_axial_skeleton0.81626358
93MP0004272_abnormal_basement_membrane0.81299678
94MP0008877_abnormal_DNA_methylation0.81250173
95MP0002089_abnormal_postnatal_growth/wei0.80740116
96MP0000467_abnormal_esophagus_morphology0.80117156
97MP0003329_amyloid_beta_deposits0.79103577
98MP0003828_pulmonary_edema0.78575169
99MP0001661_extended_life_span0.78226784
100MP0002063_abnormal_learning/memory/cond0.77713508
101MP0002925_abnormal_cardiovascular_devel0.77626620
102MP0000566_synostosis0.77055473
103MP0005508_abnormal_skeleton_morphology0.76787184
104MP0009250_abnormal_appendicular_skeleto0.75124271
105MP0003119_abnormal_digestive_system0.74911804
106MP0002896_abnormal_bone_mineralization0.74672906
107MP0000534_abnormal_ureter_morphology0.74167191
108MP0004811_abnormal_neuron_physiology0.74077351
109MP0002116_abnormal_craniofacial_bone0.71194020
110MP0005275_abnormal_skin_tensile0.69635821
111MP0003950_abnormal_plasma_membrane0.69245131
112MP0003787_abnormal_imprinting0.69047374
113MP0003984_embryonic_growth_retardation0.68730485
114MP0002822_catalepsy0.68636367
115MP0000428_abnormal_craniofacial_morphol0.68545095
116MP0002932_abnormal_joint_morphology0.68161436
117MP0002971_abnormal_brown_adipose0.67912656
118MP0003123_paternal_imprinting0.67880403
119MP0002088_abnormal_embryonic_growth/wei0.66794514
120MP0002128_abnormal_blood_circulation0.66731519
121MP0008569_lethality_at_weaning0.65933440
122MP0009672_abnormal_birth_weight0.65857530
123MP0001958_emphysema0.64970726
124MP0003122_maternal_imprinting0.64737074
125MP0003935_abnormal_craniofacial_develop0.64680388
126MP0000579_abnormal_nail_morphology0.64531151
127MP0003567_abnormal_fetal_cardiomyocyte0.64395550
128MP0004197_abnormal_fetal_growth/weight/0.63582868
129MP0000432_abnormal_head_morphology0.62827706
130MP0005167_abnormal_blood-brain_barrier0.61888868
131MP0000767_abnormal_smooth_muscle0.60844157
132MP0003879_abnormal_hair_cell0.60627792
133MP0002734_abnormal_mechanical_nocicepti0.58408421

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.93839553
2Nemaline bodies (HP:0003798)4.54010996
3Muscle fiber splitting (HP:0003555)4.02255842
4Exercise-induced myalgia (HP:0003738)3.99970163
5Bundle branch block (HP:0011710)3.95166301
6Hyporeflexia of lower limbs (HP:0002600)3.93231075
7Difficulty running (HP:0009046)3.69331868
8Ventricular tachycardia (HP:0004756)3.66243132
9Increased connective tissue (HP:0009025)3.65573570
10Exercise-induced muscle cramps (HP:0003710)3.65424232
11Difficulty climbing stairs (HP:0003551)3.55697848
12Premature rupture of membranes (HP:0001788)3.50911041
13Abnormality of the calf musculature (HP:0001430)3.49844513
14Calf muscle hypertrophy (HP:0008981)3.44200369
15Atrial fibrillation (HP:0005110)3.40237724
16Right ventricular cardiomyopathy (HP:0011663)3.39519214
17Round ear (HP:0100830)3.34993066
18Centrally nucleated skeletal muscle fibers (HP:0003687)3.26015406
19Primary atrial arrhythmia (HP:0001692)3.25616045
20Distal lower limb muscle weakness (HP:0009053)3.16256168
21Ventricular fibrillation (HP:0001663)3.14608071
22Muscle hypertrophy of the lower extremities (HP:0008968)3.09265730
23Supraventricular tachycardia (HP:0004755)3.04916000
24Ulnar deviation of the wrist (HP:0003049)3.04610092
25Type 1 muscle fiber predominance (HP:0003803)3.04110251
26Supraventricular arrhythmia (HP:0005115)3.03062633
27Subaortic stenosis (HP:0001682)3.02120170
28Abnormality of the left ventricular outflow tract (HP:0011103)3.02120170
29Syncope (HP:0001279)2.91511360
30Prolonged QT interval (HP:0001657)2.87276120
31EMG: myopathic abnormalities (HP:0003458)2.81807873
32Mildly elevated creatine phosphokinase (HP:0008180)2.79414676
33Dysmetric saccades (HP:0000641)2.75302890
34Increased variability in muscle fiber diameter (HP:0003557)2.71512236
35Lipoatrophy (HP:0100578)2.71056454
36Ventricular arrhythmia (HP:0004308)2.70690716
37Calcaneovalgus deformity (HP:0001848)2.68326006
38Obstructive sleep apnea (HP:0002870)2.67097594
39Distal arthrogryposis (HP:0005684)2.66446621
40Asymmetric septal hypertrophy (HP:0001670)2.62821328
41Heart block (HP:0012722)2.59203537
42Myoglobinuria (HP:0002913)2.59095624
43Broad face (HP:0000283)2.56318820
44Distal upper limb amyotrophy (HP:0007149)2.56226123
45Upper limb amyotrophy (HP:0009129)2.56226123
46Abnormal atrioventricular conduction (HP:0005150)2.54727916
47Abnormality of the calcaneus (HP:0008364)2.52103391
48Cerebral aneurysm (HP:0004944)2.47697589
49Myotonia (HP:0002486)2.45632492
50Hyperacusis (HP:0010780)2.45220151
51Abnormality of the lower motor neuron (HP:0002366)2.42841810
52Shallow orbits (HP:0000586)2.42042511
53Abnormality of skeletal muscle fiber size (HP:0012084)2.40023268
54Cervical subluxation (HP:0003308)2.39452096
55Atrophic scars (HP:0001075)2.38707729
56Ulnar bowing (HP:0003031)2.36146476
57Thin bony cortex (HP:0002753)2.33044884
58Atrioventricular block (HP:0001678)2.30663864
59Deformed tarsal bones (HP:0008119)2.30650423
60Fragile skin (HP:0001030)2.28167457
61Limb-girdle muscle atrophy (HP:0003797)2.26449882
62Lower limb amyotrophy (HP:0007210)2.25585534
63Hand muscle atrophy (HP:0009130)2.19019858
64Rhabdomyolysis (HP:0003201)2.18808473
65Scapular winging (HP:0003691)2.13651763
66Abnormal EKG (HP:0003115)2.13054743
67Aortic aneurysm (HP:0004942)2.12535625
68Hypoplastic ischia (HP:0003175)2.12348846
69Protrusio acetabuli (HP:0003179)2.12194502
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11519691
71Muscle fiber inclusion bodies (HP:0100299)2.09229085
72Thin ribs (HP:0000883)2.08493681
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07483075
74Bulbar palsy (HP:0001283)2.07179240
75EMG: neuropathic changes (HP:0003445)2.06202845
76Neonatal short-limb short stature (HP:0008921)2.06008575
77Aortic dissection (HP:0002647)2.04359800
78Mitral regurgitation (HP:0001653)2.04210645
79Distal lower limb amyotrophy (HP:0008944)2.04130808
80Lymphangioma (HP:0100764)2.02890961
81Broad metatarsal (HP:0001783)2.02558913
82Ankle contracture (HP:0006466)2.02402576
83Macroorchidism (HP:0000053)2.01790640
84Dilated cardiomyopathy (HP:0001644)2.01098528
85Frequent falls (HP:0002359)2.00893297
86Limb-girdle muscle weakness (HP:0003325)2.00495022
87Proximal amyotrophy (HP:0007126)1.99031014
88Hip contracture (HP:0003273)1.97055504
89Elfin facies (HP:0004428)1.95419139
90Insomnia (HP:0100785)1.94516425
91Hamartoma of the eye (HP:0010568)1.94061628
92Slender build (HP:0001533)1.92379038
93Spinal rigidity (HP:0003306)1.91350455
94Stridor (HP:0010307)1.90094511
95Palpitations (HP:0001962)1.87661057
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87159402
97Muscle stiffness (HP:0003552)1.87072721
98Turricephaly (HP:0000262)1.85638536
99Abnormality of the Achilles tendon (HP:0005109)1.85030127
100Aneurysm (HP:0002617)1.83730110
101Wormian bones (HP:0002645)1.83728145
102Bladder diverticulum (HP:0000015)1.83571120
103Limited hip movement (HP:0008800)1.83568809
104Foot dorsiflexor weakness (HP:0009027)1.82982374
105Biconcave vertebral bodies (HP:0004586)1.82761010
106Myopathic facies (HP:0002058)1.77794788
107Breech presentation (HP:0001623)1.77163249
108Enlarged penis (HP:0000040)1.77126787
109Bell-shaped thorax (HP:0001591)1.75441516
110Vascular tortuosity (HP:0004948)1.75248796
111Rapidly progressive (HP:0003678)1.72645654
112Abnormality of the ischium (HP:0003174)1.71461420
113Abnormality of dentin (HP:0010299)1.71248122
114Astrocytoma (HP:0009592)1.70804823
115Abnormality of the astrocytes (HP:0100707)1.70804823
116Achilles tendon contracture (HP:0001771)1.70554075
117Rimmed vacuoles (HP:0003805)1.69476650
118Pointed chin (HP:0000307)1.69107960
119Blue sclerae (HP:0000592)1.68736249
120Mitral valve prolapse (HP:0001634)1.68289956
121Bronchomalacia (HP:0002780)1.66870425
122Central scotoma (HP:0000603)1.66163830
123Disproportionate tall stature (HP:0001519)1.65746985
124Arterial tortuosity (HP:0005116)1.64963653
125Focal seizures (HP:0007359)1.64503080
126Long toe (HP:0010511)1.62396278
127Genetic anticipation (HP:0003743)1.61836167
128Renovascular hypertension (HP:0100817)1.61707285
129Renal duplication (HP:0000075)1.61463287
130Muscular dystrophy (HP:0003560)1.61201749
131Mask-like facies (HP:0000298)1.60916707
132Bowel diverticulosis (HP:0005222)1.60323815
133Short nail (HP:0001799)1.60070486
134Abnormality of the foot musculature (HP:0001436)1.59350302
135Wrist flexion contracture (HP:0001239)1.57909459
136Genu recurvatum (HP:0002816)1.57871608
137Neoplasm of the heart (HP:0100544)1.57675786
138Insidious onset (HP:0003587)1.56177265
139Termporal pattern (HP:0011008)1.56177265
140Heterotopia (HP:0002282)1.56010904
141Pelvic girdle muscle weakness (HP:0003749)1.55904810
142Neck muscle weakness (HP:0000467)1.55852575
143Shoulder girdle muscle weakness (HP:0003547)1.55354716
144Flat acetabular roof (HP:0003180)1.55279099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.01656765
2TTN3.81234733
3PKN22.96817688
4DMPK2.93742806
5PRKD32.79550334
6LMTK22.40160001
7RIPK12.37286772
8MST1R2.25043953
9PHKG22.19441113
10PHKG12.19441113
11CDK122.16211066
12ICK2.11339848
13LATS21.94344958
14PDK41.94015840
15PDK31.94015840
16NEK11.87664199
17STK381.84263450
18MET1.83180394
19EPHA21.81472690
20OBSCN1.77374223
21PAK61.76136799
22TAOK11.75356367
23EEF2K1.66736150
24LATS11.65767255
25PDGFRA1.62811940
26MAP3K91.61060685
27SMG11.58857686
28MAP2K31.48971505
29FGFR41.46116199
30CAMK1G1.44333940
31MAP3K41.42090905
32MAP3K71.40981437
33MARK11.39926294
34MAP3K101.30754071
35MAP3K61.29316173
36KSR21.27488587
37TYRO31.19527221
38CAMK1D1.19133670
39STK38L1.18541766
40CAMKK11.15185006
41PAK31.12602491
42PIK3CA1.11538650
43EPHB21.09579138
44MTOR1.09433832
45PTK61.08797778
46MAPK121.08577203
47CDC42BPA1.05084698
48IRAK31.01946692
49PDK21.00295881
50DDR21.00191558
51PRPF4B0.95867824
52RET0.92387441
53SGK30.90761929
54ALK0.89880644
55DAPK20.89701342
56KSR10.88846664
57ROCK10.87172693
58BMX0.87106543
59SCYL20.85554050
60ILK0.85214878
61WNK10.84767336
62PTK2B0.83787244
63PRKCH0.81771371
64PRKAA10.79597996
65EPHB10.77643600
66MUSK0.76423772
67MINK10.75935690
68RPS6KL10.74895569
69RPS6KC10.74895569
70SIK10.73121341
71NTRK30.72454142
72MAPK110.71399019
73FER0.70246587
74SIK20.68699900
75PRKD10.67824313
76PTK20.67126746
77MAP2K60.67093655
78MAP2K40.66260471
79MYLK0.64474399
80TRPM70.62854354
81TESK10.62043456
82STK110.61652079
83MAPKAPK30.61273024
84PDGFRB0.60595257
85NTRK20.59860920
86PDPK10.59651762
87MARK20.58407356
88MOS0.56049483
89PRKG20.56004660
90NEK20.55456785
91WNK40.54261366
92PAK20.54173363
93PIK3CG0.53847049
94NEK90.53846107
95RPS6KA60.53515785
96LIMK10.53047283
97PDK10.52930491
98CAMK2G0.52375294
99DYRK1B0.51350677
100RPS6KA20.50375317
101MAP2K10.49920718
102AKT20.49061606
103CAMK40.48685394
104PRKAA20.48431950
105SGK20.45456093
106NTRK10.45453540
107MAPK100.45122201
108CDK50.44525075
109PINK10.44460473
110BRD40.44440441
111MAP3K20.44094288
112SGK10.43242329
113ERN10.42459103
114ROCK20.41455230
115AKT30.41013584
116RPS6KA30.40147437
117MAP3K130.37837787
118CAMK2D0.37175126
119MAPK80.36274848
120FGFR10.35356503
121ERBB20.35288640
122MAP3K10.34410704
123PNCK0.33345498
124SGK4940.32968086
125SGK2230.32968086
126CDK90.32856206
127CAMK2B0.32809735
128PRKD20.32767044
129CAMK10.32235056
130MAPK70.31677668
131MAP3K50.30725892
132PAK40.30602411
133RPS6KA10.30531799
134MAPK40.28647690
135CDK11A0.28360106

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.60649604
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47181839
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35304109
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20709368
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93153042
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88416979
7Fructose and mannose metabolism_Homo sapiens_hsa000511.83446189
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78895292
9Cardiac muscle contraction_Homo sapiens_hsa042601.78810462
10Type II diabetes mellitus_Homo sapiens_hsa049301.50928320
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.48938405
12Notch signaling pathway_Homo sapiens_hsa043301.48188832
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41402274
14Other glycan degradation_Homo sapiens_hsa005111.40028576
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39966815
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37887721
17Insulin secretion_Homo sapiens_hsa049111.37537982
18Dorso-ventral axis formation_Homo sapiens_hsa043201.36474288
19mTOR signaling pathway_Homo sapiens_hsa041501.33564304
20Adherens junction_Homo sapiens_hsa045201.33392994
21Focal adhesion_Homo sapiens_hsa045101.30904971
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30863313
23Gastric acid secretion_Homo sapiens_hsa049711.29750895
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29630744
25Oxytocin signaling pathway_Homo sapiens_hsa049211.29062274
26Endometrial cancer_Homo sapiens_hsa052131.26908858
27Long-term potentiation_Homo sapiens_hsa047201.26432247
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25914595
29Circadian entrainment_Homo sapiens_hsa047131.25810795
30Glioma_Homo sapiens_hsa052141.25326138
31Arginine biosynthesis_Homo sapiens_hsa002201.25157991
32Insulin signaling pathway_Homo sapiens_hsa049101.25155967
33Viral myocarditis_Homo sapiens_hsa054161.25072444
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23873105
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23290226
36Glucagon signaling pathway_Homo sapiens_hsa049221.20691179
37Tight junction_Homo sapiens_hsa045301.19909613
38Olfactory transduction_Homo sapiens_hsa047401.19300818
39Estrogen signaling pathway_Homo sapiens_hsa049151.15155622
40Lysine degradation_Homo sapiens_hsa003101.14844610
41Synaptic vesicle cycle_Homo sapiens_hsa047211.14349021
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13242278
43Insulin resistance_Homo sapiens_hsa049311.12258950
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10564473
45GnRH signaling pathway_Homo sapiens_hsa049121.10373548
46Cholinergic synapse_Homo sapiens_hsa047251.09536886
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.07274530
48Galactose metabolism_Homo sapiens_hsa000521.07039683
49Gap junction_Homo sapiens_hsa045401.05999562
50Proteoglycans in cancer_Homo sapiens_hsa052051.04354757
51Pentose phosphate pathway_Homo sapiens_hsa000301.02020468
52AMPK signaling pathway_Homo sapiens_hsa041521.01470364
53Dopaminergic synapse_Homo sapiens_hsa047281.01134495
54Renin secretion_Homo sapiens_hsa049241.01053179
55Salivary secretion_Homo sapiens_hsa049701.00883002
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99726352
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97759160
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96486857
59VEGF signaling pathway_Homo sapiens_hsa043700.95760424
60cAMP signaling pathway_Homo sapiens_hsa040240.95462980
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.95087026
62Amphetamine addiction_Homo sapiens_hsa050310.93852655
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93740600
64ECM-receptor interaction_Homo sapiens_hsa045120.92106508
65Chronic myeloid leukemia_Homo sapiens_hsa052200.91708995
66ErbB signaling pathway_Homo sapiens_hsa040120.91177868
67Renal cell carcinoma_Homo sapiens_hsa052110.89291363
68Carbon metabolism_Homo sapiens_hsa012000.88670124
69Biosynthesis of amino acids_Homo sapiens_hsa012300.88639802
70Hippo signaling pathway_Homo sapiens_hsa043900.87765723
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.87008286
72Prion diseases_Homo sapiens_hsa050200.86384818
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.86071392
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.82200786
75GABAergic synapse_Homo sapiens_hsa047270.82149513
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81476686
77HIF-1 signaling pathway_Homo sapiens_hsa040660.81186247
78Calcium signaling pathway_Homo sapiens_hsa040200.80916559
79Arginine and proline metabolism_Homo sapiens_hsa003300.80748620
80Non-small cell lung cancer_Homo sapiens_hsa052230.78877496
81Glutamatergic synapse_Homo sapiens_hsa047240.78344055
82Melanogenesis_Homo sapiens_hsa049160.77340071
83Axon guidance_Homo sapiens_hsa043600.77142384
84Amoebiasis_Homo sapiens_hsa051460.76413325
85Oocyte meiosis_Homo sapiens_hsa041140.76269127
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75197974
87Bladder cancer_Homo sapiens_hsa052190.74472460
88Pancreatic cancer_Homo sapiens_hsa052120.73870224
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73466199
90Acute myeloid leukemia_Homo sapiens_hsa052210.72695748
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71132314
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70917775
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70899330
94Morphine addiction_Homo sapiens_hsa050320.70121376
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69386634
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.69249960
97Nicotine addiction_Homo sapiens_hsa050330.69138135
98Cocaine addiction_Homo sapiens_hsa050300.66285420
99MAPK signaling pathway_Homo sapiens_hsa040100.66107330
100Hedgehog signaling pathway_Homo sapiens_hsa043400.65897274
101PPAR signaling pathway_Homo sapiens_hsa033200.64814698
102MicroRNAs in cancer_Homo sapiens_hsa052060.64746165
103Fatty acid biosynthesis_Homo sapiens_hsa000610.64087376
104Bile secretion_Homo sapiens_hsa049760.63860959
105Colorectal cancer_Homo sapiens_hsa052100.63544175
106Protein digestion and absorption_Homo sapiens_hsa049740.63385020
107Inositol phosphate metabolism_Homo sapiens_hsa005620.63079676
108Prolactin signaling pathway_Homo sapiens_hsa049170.62059601
109Prostate cancer_Homo sapiens_hsa052150.61739900
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60864561
111Choline metabolism in cancer_Homo sapiens_hsa052310.60509486
112Nitrogen metabolism_Homo sapiens_hsa009100.59960437
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59835327
114Rap1 signaling pathway_Homo sapiens_hsa040150.59418678
115Small cell lung cancer_Homo sapiens_hsa052220.59180164
116Thyroid cancer_Homo sapiens_hsa052160.58494696
117Basal cell carcinoma_Homo sapiens_hsa052170.57707514
118Circadian rhythm_Homo sapiens_hsa047100.57151909
119Fatty acid metabolism_Homo sapiens_hsa012120.56648035
120Fatty acid degradation_Homo sapiens_hsa000710.56632424
121Wnt signaling pathway_Homo sapiens_hsa043100.55890998
122Thyroid hormone synthesis_Homo sapiens_hsa049180.55434367
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54638682
124Phenylalanine metabolism_Homo sapiens_hsa003600.54045364
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.53734663
126Sulfur relay system_Homo sapiens_hsa041220.51719994

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