MASP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.23075129
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66593728
3L-phenylalanine catabolic process (GO:0006559)7.66593728
4epoxygenase P450 pathway (GO:0019373)7.64111395
5omega-hydroxylase P450 pathway (GO:0097267)7.32449621
6L-phenylalanine metabolic process (GO:0006558)7.31564595
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31564595
8aromatic amino acid family catabolic process (GO:0009074)6.90093028
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31378286
10tryptophan catabolic process (GO:0006569)6.25997079
11indole-containing compound catabolic process (GO:0042436)6.25997079
12indolalkylamine catabolic process (GO:0046218)6.25997079
13kynurenine metabolic process (GO:0070189)6.12397370
14bile acid biosynthetic process (GO:0006699)6.02771517
15oxidative demethylation (GO:0070989)5.96117334
16tryptophan metabolic process (GO:0006568)5.88443646
17glyoxylate metabolic process (GO:0046487)5.79621155
18urea cycle (GO:0000050)5.67769780
19urea metabolic process (GO:0019627)5.67769780
20drug metabolic process (GO:0017144)5.67634425
21regulation of plasminogen activation (GO:0010755)5.65072873
22negative regulation of fibrinolysis (GO:0051918)5.65063504
23alpha-linolenic acid metabolic process (GO:0036109)5.63817815
24high-density lipoprotein particle remodeling (GO:0034375)5.55944384
25regulation of fibrinolysis (GO:0051917)5.47155719
26regulation of protein activation cascade (GO:2000257)5.44034197
27phenylpropanoid metabolic process (GO:0009698)5.43890334
28complement activation, alternative pathway (GO:0006957)5.42120320
29peptidyl-glutamic acid carboxylation (GO:0017187)5.42036454
30protein carboxylation (GO:0018214)5.42036454
31sulfur amino acid catabolic process (GO:0000098)5.31538353
32cysteine metabolic process (GO:0006534)5.30606516
33nitrogen cycle metabolic process (GO:0071941)5.21684465
34bile acid metabolic process (GO:0008206)5.14320959
35serine family amino acid catabolic process (GO:0009071)5.12867860
36regulation of complement activation (GO:0030449)5.07704914
37aromatic amino acid family metabolic process (GO:0009072)5.01182631
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88044127
39reverse cholesterol transport (GO:0043691)4.86167545
40alkaloid metabolic process (GO:0009820)4.85301644
41tyrosine metabolic process (GO:0006570)4.84389489
42regulation of cholesterol esterification (GO:0010872)4.83924892
43regulation of triglyceride catabolic process (GO:0010896)4.81323868
44acute-phase response (GO:0006953)4.79362031
45protein-lipid complex remodeling (GO:0034368)4.75906665
46macromolecular complex remodeling (GO:0034367)4.75906665
47plasma lipoprotein particle remodeling (GO:0034369)4.75906665
48homocysteine metabolic process (GO:0050667)4.75412413
49negative regulation of blood coagulation (GO:0030195)4.73353689
50negative regulation of hemostasis (GO:1900047)4.73353689
51alpha-amino acid catabolic process (GO:1901606)4.67644129
52acylglycerol homeostasis (GO:0055090)4.66577550
53triglyceride homeostasis (GO:0070328)4.66577550
54regulation of humoral immune response (GO:0002920)4.65184076
55negative regulation of protein activation cascade (GO:2000258)4.64363396
56S-adenosylmethionine metabolic process (GO:0046500)4.62979240
57amino-acid betaine metabolic process (GO:0006577)4.58608029
58ethanol metabolic process (GO:0006067)4.57464249
59lysine metabolic process (GO:0006553)4.56335550
60lysine catabolic process (GO:0006554)4.56335550
61negative regulation of cholesterol transport (GO:0032375)4.54761868
62negative regulation of sterol transport (GO:0032372)4.54761868
63phospholipid efflux (GO:0033700)4.54382569
64coenzyme catabolic process (GO:0009109)4.49049770
65glycine metabolic process (GO:0006544)4.44814062
66cellular ketone body metabolic process (GO:0046950)4.44379854
67imidazole-containing compound metabolic process (GO:0052803)4.43642682
68bile acid and bile salt transport (GO:0015721)4.43211737
69indolalkylamine metabolic process (GO:0006586)4.42966391
70plasma lipoprotein particle clearance (GO:0034381)4.36188261
71cellular biogenic amine catabolic process (GO:0042402)4.34974882
72amine catabolic process (GO:0009310)4.34974882
73negative regulation of wound healing (GO:0061045)4.29252143
74cellular amino acid catabolic process (GO:0009063)4.29176958
75positive regulation of blood coagulation (GO:0030194)4.28438301
76positive regulation of hemostasis (GO:1900048)4.28438301
77glutamate metabolic process (GO:0006536)4.28410671
78cellular glucuronidation (GO:0052695)4.25670618
79negative regulation of coagulation (GO:0050819)4.25560285
80cholesterol efflux (GO:0033344)4.23033271
81serine family amino acid metabolic process (GO:0009069)4.18395474
82benzene-containing compound metabolic process (GO:0042537)4.14189837
83ethanol oxidation (GO:0006069)4.10299404
84regulation of lipoprotein particle clearance (GO:0010984)4.08948018
85cellular modified amino acid catabolic process (GO:0042219)4.08356226
86dicarboxylic acid biosynthetic process (GO:0043650)4.04656432
87fibrinolysis (GO:0042730)4.04341192
88arginine metabolic process (GO:0006525)4.04138718
89serine family amino acid biosynthetic process (GO:0009070)4.00786338
90negative regulation of complement activation (GO:0045916)3.99664999
91aldehyde catabolic process (GO:0046185)3.99309439
92plasma lipoprotein particle assembly (GO:0034377)3.98048798
93low-density lipoprotein particle remodeling (GO:0034374)3.97765173
94drug catabolic process (GO:0042737)3.95527320
95positive regulation of coagulation (GO:0050820)3.92453278
96blood coagulation, intrinsic pathway (GO:0007597)3.89638822
97hormone catabolic process (GO:0042447)3.85279512
98cofactor catabolic process (GO:0051187)3.85168156
99ketone body metabolic process (GO:1902224)3.84614083
100regulation of bile acid biosynthetic process (GO:0070857)3.81492509
101heme transport (GO:0015886)3.77721777
102glucuronate metabolic process (GO:0019585)3.77388257
103uronic acid metabolic process (GO:0006063)3.77388257
104positive regulation of lipoprotein lipase activity (GO:0051006)3.77254144
105positive regulation of triglyceride lipase activity (GO:0061365)3.77254144
106flavonoid metabolic process (GO:0009812)3.77208217
107cytolysis (GO:0019835)3.75082045
108phospholipid homeostasis (GO:0055091)3.75062503
109cholesterol homeostasis (GO:0042632)3.75009772
110organic acid catabolic process (GO:0016054)3.74277569
111carboxylic acid catabolic process (GO:0046395)3.74277569
112negative regulation of lipase activity (GO:0060192)3.73618035
113very-low-density lipoprotein particle assembly (GO:0034379)3.73394007
114acute inflammatory response (GO:0002526)3.72274415
115positive regulation of lipid catabolic process (GO:0050996)3.71680490
116acetyl-CoA metabolic process (GO:0006084)3.70938101
117positive regulation of fatty acid biosynthetic process (GO:0045723)3.70097624
118sterol homeostasis (GO:0055092)3.68656968
119regulation of cholesterol homeostasis (GO:2000188)3.67900232
120* protein activation cascade (GO:0072376)3.66464988
121killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.65385797
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.65385797
123short-chain fatty acid metabolic process (GO:0046459)3.64119052
124* complement activation (GO:0006956)3.62059522
125intestinal cholesterol absorption (GO:0030299)3.61799401
126* complement activation, classical pathway (GO:0006958)3.61722623
127plasma lipoprotein particle organization (GO:0071827)3.61355384
128NAD biosynthetic process (GO:0009435)3.60870045
129opsonization (GO:0008228)3.56724692
130protein-lipid complex assembly (GO:0065005)3.56073188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.43697341
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22091320
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07792881
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.52867081
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.36819418
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14469968
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74501369
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07520175
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04551603
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07135956
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0297480
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94951751
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92356344
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.60331251
15HTT_18923047_ChIP-ChIP_STHdh_Human1.59659987
16CLOCK_20551151_ChIP-Seq_293T_Human1.50518862
17GATA1_22025678_ChIP-Seq_K562_Human1.44959683
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39901409
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27720089
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24350811
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21501593
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16663202
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15842633
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08555998
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03023730
26ER_23166858_ChIP-Seq_MCF-7_Human0.98479239
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97134175
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96036175
29NFE2_27457419_Chip-Seq_LIVER_Mouse0.94711466
30SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89884010
31ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87230120
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87168313
33PIAS1_25552417_ChIP-Seq_VCAP_Human0.86664531
34RAC3_21632823_ChIP-Seq_H3396_Human0.85133143
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83466523
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83385704
37AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83296380
38POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82892011
39EZH2_27294783_Chip-Seq_NPCs_Mouse0.81937348
40EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81846006
41IGF1R_20145208_ChIP-Seq_DFB_Human0.81621724
42* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80492743
43MYC_19829295_ChIP-Seq_ESCs_Human0.80447912
44RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79762630
45GBX2_23144817_ChIP-Seq_PC3_Human0.78814698
46IRF8_22096565_ChIP-ChIP_GC-B_Human0.78221329
47GATA4_25053715_ChIP-Seq_YYC3_Human0.78089002
48* HNFA_21074721_ChIP-Seq_CACO-2_Human0.77330167
49ERA_21632823_ChIP-Seq_H3396_Human0.77277374
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76293928
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75976159
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74888658
53* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74697161
54RARA_24833708_ChIP-Seq_LIVER_Mouse0.74566386
55* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74294710
56SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74272875
57E2F1_20622854_ChIP-Seq_HELA_Human0.73104383
58PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72514668
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72508220
60* PHF8_20622853_ChIP-Seq_HELA_Human0.71962494
61SOX2_21211035_ChIP-Seq_LN229_Human0.71589324
62ZNF263_19887448_ChIP-Seq_K562_Human0.71478152
63OCT4_20526341_ChIP-Seq_ESCs_Human0.70409993
64* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69658631
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68992574
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68919587
67SOX2_19829295_ChIP-Seq_ESCs_Human0.68301483
68NANOG_19829295_ChIP-Seq_ESCs_Human0.68301483
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.67393194
70FOXH1_21741376_ChIP-Seq_EPCs_Human0.67220325
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66931531
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66772194
73SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66229217
74* GATA6_21074721_ChIP-Seq_CACO-2_Human0.65898876
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.65252880
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.65007098
77RARB_24833708_ChIP-Seq_LIVER_Mouse0.64794904
78CRX_20693478_ChIP-Seq_RETINA_Mouse0.64579364
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64521286
80* NFYA_21822215_ChIP-Seq_K562_Human0.63754391
81DROSHA_22980978_ChIP-Seq_HELA_Human0.63484466
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62448152
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62448152
84* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.62286450
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.62060469
86* ETV1_20927104_ChIP-Seq_GIST48_Human0.61986126
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.60985514
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60907005
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.60706539
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59951604
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59817024
92STAT3_23295773_ChIP-Seq_U87_Human0.59626175
93* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59306469
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58949769
95NANOG_20526341_ChIP-Seq_ESCs_Human0.58755487
96TP53_18474530_ChIP-ChIP_U2OS_Human0.58058966
97* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57947123
98TP53_16413492_ChIP-PET_HCT116_Human0.57844085
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.57825677
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57652679
101CBP_20019798_ChIP-Seq_JUKART_Human0.57544379
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.57544379
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57286969
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.57063094
105CEBPB_22108803_ChIP-Seq_LS180_Human0.56429649
106GATA3_26560356_Chip-Seq_TH2_Human0.56077413
107LXR_22292898_ChIP-Seq_THP-1_Human0.53174804
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53001520
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53000556
110AR_20517297_ChIP-Seq_VCAP_Human0.52591394
111EGR1_19032775_ChIP-ChIP_M12_Human0.52414308
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.52332809
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51974362
114MYC_19915707_ChIP-ChIP_AK7_Human0.51711957
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51426267
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50570607
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.49362643
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.49287413
119CBP_21632823_ChIP-Seq_H3396_Human0.48270351
120TAF15_26573619_Chip-Seq_HEK293_Human0.48220724
121STAT1_17558387_ChIP-Seq_HELA_Human0.47113349
122P53_21459846_ChIP-Seq_SAOS-2_Human0.46960423
123PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44929756
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43596936
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.42385004
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42356944
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.41951271
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41739729
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.41204284
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40882976
131GATA1_19941826_ChIP-Seq_K562_Human0.40809711
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.40713596
133TAF2_19829295_ChIP-Seq_ESCs_Human0.40435978
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39474930
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.39137967
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38867354
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38507103
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.38405795
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.38216981
140BCAT_22108803_ChIP-Seq_LS180_Human0.37986072
141GATA2_19941826_ChIP-Seq_K562_Human0.37248297
142GATA6_25053715_ChIP-Seq_YYC3_Human0.37087184
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36171441
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.35864552
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35075533
146LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34932888
147NCOR_22424771_ChIP-Seq_293T_Human0.34208636
148IRF1_19129219_ChIP-ChIP_H3396_Human0.34136768
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33403799
150ERG_20517297_ChIP-Seq_VCAP_Human0.33294480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30593058
2MP0005360_urolithiasis7.56032838
3MP0005085_abnormal_gallbladder_physiolo6.51277520
4MP0005365_abnormal_bile_salt6.21043878
5MP0008875_abnormal_xenobiotic_pharmacok5.18403230
6MP0003806_abnormal_nucleotide_metabolis4.25317270
7MP0003252_abnormal_bile_duct3.94748763
8MP0010329_abnormal_lipoprotein_level3.59849754
9MP0009840_abnormal_foam_cell3.26005812
10MP0005083_abnormal_biliary_tract3.12618380
11MP0003195_calcinosis2.84919735
12MP0005332_abnormal_amino_acid2.74756984
13MP0001666_abnormal_nutrient_absorption2.60195699
14MP0003191_abnormal_cellular_cholesterol2.32614195
15MP0000609_abnormal_liver_physiology2.17230918
16MP0004019_abnormal_vitamin_homeostasis2.12765523
17MP0002118_abnormal_lipid_homeostasis2.10985852
18MP0003868_abnormal_feces_composition1.96844215
19MP0002138_abnormal_hepatobiliary_system1.93511696
20MP0005319_abnormal_enzyme/_coenzyme1.82901356
21MP0001764_abnormal_homeostasis1.67404398
22MP0009697_abnormal_copulation1.60809410
23MP0005584_abnormal_enzyme/coenzyme_acti1.55468352
24MP0003011_delayed_dark_adaptation1.42486368
25MP0005451_abnormal_body_composition1.42027566
26MP0003656_abnormal_erythrocyte_physiolo1.27069926
27MP0003186_abnormal_redox_activity1.23403924
28MP0009643_abnormal_urine_homeostasis1.19830886
29MP0000598_abnormal_liver_morphology1.18300588
30MP0005647_abnormal_sex_gland1.16197726
31MP0003705_abnormal_hypodermis_morpholog1.14613606
32MP0000604_amyloidosis1.06762943
33MP0009764_decreased_sensitivity_to1.04690963
34MP0002254_reproductive_system_inflammat1.02269398
35MP0009763_increased_sensitivity_to1.01867608
36MP0005187_abnormal_penis_morphology0.99987980
37MP0010368_abnormal_lymphatic_system0.98120129
38MP0005636_abnormal_mineral_homeostasis0.90738666
39MP0008469_abnormal_protein_level0.88055219
40MP0009642_abnormal_blood_homeostasis0.86742050
41MP0005408_hypopigmentation0.83509696
42MP0001986_abnormal_taste_sensitivity0.82195600
43MP0006036_abnormal_mitochondrial_physio0.81317433
44MP0005670_abnormal_white_adipose0.80508770
45MP0005376_homeostasis/metabolism_phenot0.79836793
46MP0005084_abnormal_gallbladder_morpholo0.78615915
47MP0009765_abnormal_xenobiotic_induced0.78164165
48MP0002078_abnormal_glucose_homeostasis0.77915209
49MP0005220_abnormal_exocrine_pancreas0.76185348
50MP0003879_abnormal_hair_cell0.75474120
51MP0002876_abnormal_thyroid_physiology0.75464488
52MP0002971_abnormal_brown_adipose0.72024928
53MP0001915_intracranial_hemorrhage0.71949448
54MP0005334_abnormal_fat_pad0.69221123
55MP0004130_abnormal_muscle_cell0.68236475
56MP0005535_abnormal_body_temperature0.67230746
57MP0003690_abnormal_glial_cell0.66293752
58MP0001661_extended_life_span0.65896072
59MP0005266_abnormal_metabolism0.65371564
60MP0009053_abnormal_anal_canal0.62635659
61MP0003329_amyloid_beta_deposits0.62417351
62MP0000639_abnormal_adrenal_gland0.61200684
63MP0006035_abnormal_mitochondrial_morpho0.57017417
64MP0001756_abnormal_urination0.56408991
65MP0005448_abnormal_energy_balance0.55539768
66MP0002282_abnormal_trachea_morphology0.54845486
67MP0005464_abnormal_platelet_physiology0.51707363
68MP0002822_catalepsy0.49928001
69MP0009785_altered_susceptibility_to0.49008885
70MP0005395_other_phenotype0.48854085
71MP0003718_maternal_effect0.47100331
72MP0002249_abnormal_larynx_morphology0.46593107
73MP0002928_abnormal_bile_duct0.46430520
74MP0003638_abnormal_response/metabolism_0.46214885
75MP0008874_decreased_physiological_sensi0.45809712
76MP0008873_increased_physiological_sensi0.44220773
77MP0004381_abnormal_hair_follicle0.43861727
78MP0002837_dystrophic_cardiac_calcinosis0.42794550
79MP0002136_abnormal_kidney_physiology0.42602949
80MP0003724_increased_susceptibility_to0.42283180
81MP0004782_abnormal_surfactant_physiolog0.41899593
82MP0003436_decreased_susceptibility_to0.41706480
83MP0003953_abnormal_hormone_level0.40659560
84MP0005248_abnormal_Harderian_gland0.39158570
85MP0003075_altered_response_to0.38721573
86MP0008872_abnormal_physiological_respon0.38202361
87MP0000579_abnormal_nail_morphology0.38027080
88MP0005166_decreased_susceptibility_to0.37368019
89MP0009672_abnormal_birth_weight0.36389812
90MP0003959_abnormal_lean_body0.36209587
91MP0005666_abnormal_adipose_tissue0.35971486
92MP0005551_abnormal_eye_electrophysiolog0.35465065
93MP0003646_muscle_fatigue0.34753580
94MP0009384_cardiac_valve_regurgitation0.33822891
95MP0002796_impaired_skin_barrier0.32291889
96MP0009115_abnormal_fat_cell0.32019399
97MP0001243_abnormal_dermal_layer0.31512043
98MP0002970_abnormal_white_adipose0.31101678
99MP0000230_abnormal_systemic_arterial0.30888303
100MP0004883_abnormal_blood_vessel0.30712868
101MP0002168_other_aberrant_phenotype0.30501065
102MP0000249_abnormal_blood_vessel0.30413108
103MP0001853_heart_inflammation0.29617788
104MP0001502_abnormal_circadian_rhythm0.29272301
105MP0006082_CNS_inflammation0.28929230
106MP0004142_abnormal_muscle_tone0.28512112
107MP0001881_abnormal_mammary_gland0.28204735
108MP0005167_abnormal_blood-brain_barrier0.27657204
109MP0002332_abnormal_exercise_endurance0.27648743
110MP0003172_abnormal_lysosome_physiology0.26148640
111MP0001845_abnormal_inflammatory_respons0.25889582
112MP0002090_abnormal_vision0.24998090
113MP0005058_abnormal_lysosome_morphology0.24876376
114MP0000685_abnormal_immune_system0.24363641
115MP0000427_abnormal_hair_cycle0.24159414
116MP0005164_abnormal_response_to0.23960786
117MP0002132_abnormal_respiratory_system0.23836944
118MP0003633_abnormal_nervous_system0.23798385
119MP0001851_eye_inflammation0.21583692
120MP0004043_abnormal_pH_regulation0.20064717
121MP0003631_nervous_system_phenotype0.19126454
122MP0005645_abnormal_hypothalamus_physiol0.18944528
123MP0003632_abnormal_nervous_system0.17601955
124MP0001944_abnormal_pancreas_morphology0.16990790
125MP0005025_abnormal_response_to0.16076132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.48057654
2Deep venous thrombosis (HP:0002625)7.46025356
3Intrahepatic cholestasis (HP:0001406)7.37176222
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69808869
5Prolonged partial thromboplastin time (HP:0003645)6.69731055
6Hypobetalipoproteinemia (HP:0003563)6.45319149
7Xanthomatosis (HP:0000991)6.30238188
8Hyperlipoproteinemia (HP:0010980)5.62248572
9Complement deficiency (HP:0004431)5.48472185
10Joint hemorrhage (HP:0005261)4.85809157
11Hypolipoproteinemia (HP:0010981)4.82873450
12Hyperammonemia (HP:0001987)4.58993496
13Epidermoid cyst (HP:0200040)4.53767598
14Abnormality of the common coagulation pathway (HP:0010990)4.52219855
15Hyperglycinemia (HP:0002154)4.47690075
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41585807
17Abnormality of methionine metabolism (HP:0010901)4.28597628
18Ketosis (HP:0001946)4.26643745
19Hypoalphalipoproteinemia (HP:0003233)4.23091354
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.22416891
21Fat malabsorption (HP:0002630)4.14417034
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10259486
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10193630
24Abnormality of complement system (HP:0005339)3.99792025
25Abnormality of glycine metabolism (HP:0010895)3.91958140
26Abnormality of serine family amino acid metabolism (HP:0010894)3.91958140
27Hyperglycinuria (HP:0003108)3.91373435
28Abnormality of pyrimidine metabolism (HP:0004353)3.84770317
29Abnormality of the intrinsic pathway (HP:0010989)3.83522442
30Hypoglycemic coma (HP:0001325)3.81766867
31Conjugated hyperbilirubinemia (HP:0002908)3.77501271
32Hypercholesterolemia (HP:0003124)3.65202515
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35581177
34Hyperbilirubinemia (HP:0002904)3.34988832
35Abnormality of fatty-acid metabolism (HP:0004359)3.29996085
36Steatorrhea (HP:0002570)3.13687714
37Spontaneous abortion (HP:0005268)3.13570203
38Delayed CNS myelination (HP:0002188)3.09956861
39Abnormality of serum amino acid levels (HP:0003112)3.07613884
40Abnormality of nucleobase metabolism (HP:0010932)3.03127409
41Hypochromic microcytic anemia (HP:0004840)3.02486344
42Myocardial infarction (HP:0001658)2.99714406
43Ketoacidosis (HP:0001993)2.99178513
44Hepatocellular carcinoma (HP:0001402)2.98412668
45Reduced antithrombin III activity (HP:0001976)2.86933125
46Fair hair (HP:0002286)2.86757242
47Skin nodule (HP:0200036)2.81911788
48Pulmonary embolism (HP:0002204)2.77544074
49Systemic lupus erythematosus (HP:0002725)2.75867025
50Metabolic acidosis (HP:0001942)2.73334065
51Neonatal hypoglycemia (HP:0001998)2.67254099
52Abnormality of purine metabolism (HP:0004352)2.62305955
53Lethargy (HP:0001254)2.58611680
54Acanthocytosis (HP:0001927)2.57892954
55Vascular calcification (HP:0004934)2.56905494
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53230562
57Dicarboxylic aciduria (HP:0003215)2.53230562
58Abnormal gallbladder morphology (HP:0012437)2.50367461
59Hypoglycemic seizures (HP:0002173)2.47465589
60Arthropathy (HP:0003040)2.46242198
61Glomerulonephritis (HP:0000099)2.44852211
62Mitral stenosis (HP:0001718)2.44577404
63Spastic diplegia (HP:0001264)2.44519488
64Cholelithiasis (HP:0001081)2.43142953
65Osteomalacia (HP:0002749)2.42739858
66Gout (HP:0001997)2.41450581
67Cerebral edema (HP:0002181)2.41030570
68Purpura (HP:0000979)2.40152113
69Cholecystitis (HP:0001082)2.40062979
70Abnormal gallbladder physiology (HP:0012438)2.40062979
71Recurrent gram-negative bacterial infections (HP:0005420)2.37942292
72Irritability (HP:0000737)2.35031985
73Neonatal onset (HP:0003623)2.34365246
74Amyloidosis (HP:0011034)2.32296498
75Cardiovascular calcification (HP:0011915)2.27131986
76Gingival bleeding (HP:0000225)2.24396204
77Malnutrition (HP:0004395)2.23411359
78Abnormal biliary tract physiology (HP:0012439)2.23207058
79Bile duct proliferation (HP:0001408)2.23207058
80Esophageal varix (HP:0002040)2.18570757
81Gangrene (HP:0100758)2.16161535
82Menorrhagia (HP:0000132)2.15830653
83Brushfield spots (HP:0001088)2.15056455
84Sensorimotor neuropathy (HP:0007141)2.13971839
85Enlarged kidneys (HP:0000105)2.12710750
86Pancreatitis (HP:0001733)2.12524447
87Thrombophlebitis (HP:0004418)2.10657804
88Late onset (HP:0003584)2.10066344
89Vomiting (HP:0002013)2.04898204
90Opisthotonus (HP:0002179)2.04182980
91Abnormality of the gallbladder (HP:0005264)2.03270799
92Poikilocytosis (HP:0004447)2.03205670
93Generalized hypopigmentation of hair (HP:0011358)2.02753618
94Hemorrhage of the eye (HP:0011885)2.01619721
95Hyperinsulinemic hypoglycemia (HP:0000825)2.00850983
96Generalized aminoaciduria (HP:0002909)1.98310471
97Rickets (HP:0002748)1.94560345
98Abnormality of iron homeostasis (HP:0011031)1.88793551
99Hypophosphatemic rickets (HP:0004912)1.88679180
100Epistaxis (HP:0000421)1.87802625
101Hyperphosphaturia (HP:0003109)1.87337494
102Abnormal cartilage morphology (HP:0002763)1.86998584
103Abnormality of transition element cation homeostasis (HP:0011030)1.85690585
104Increased serum ferritin (HP:0003281)1.83747916
105Atrioventricular block (HP:0001678)1.83635348
106Renal cortical cysts (HP:0000803)1.83090559
107Elevated hepatic transaminases (HP:0002910)1.82010922
108Status epilepticus (HP:0002133)1.81865647
109Abnormality of proline metabolism (HP:0010907)1.81153276
110Hydroxyprolinuria (HP:0003080)1.81153276
111Abnormal enzyme/coenzyme activity (HP:0012379)1.81056149
112Abnormality of urine glucose concentration (HP:0011016)1.78099724
113Glycosuria (HP:0003076)1.78099724
114Alkalosis (HP:0001948)1.77292030
115Hyperglycemia (HP:0003074)1.74856886
116Abnormality of vitamin metabolism (HP:0100508)1.72587952
117Nephritis (HP:0000123)1.72319420
118Elevated alkaline phosphatase (HP:0003155)1.72252211
119Joint swelling (HP:0001386)1.66538403
120Hypochromic anemia (HP:0001931)1.65111904
121Abnormality of alkaline phosphatase activity (HP:0004379)1.56805028
122Bifid scrotum (HP:0000048)1.53334760
123Abnormal urine phosphate concentration (HP:0012599)1.53236429
124Facial shape deformation (HP:0011334)1.49008350
125Potter facies (HP:0002009)1.49008350
126Abnormality of the Achilles tendon (HP:0005109)1.48407165
127Submucous cleft hard palate (HP:0000176)1.44749218
128Cerebral palsy (HP:0100021)1.44282373
129Blue irides (HP:0000635)1.43293273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15032871
2FGFR44.67233366
3SIK14.66749811
4ERN14.47624214
5TAOK33.15868081
6ERBB43.08595767
7INSRR3.06077354
8CDK122.79486263
9MAP2K42.36722275
10PKN22.12639577
11NLK2.07499705
12MST1R2.03468596
13CASK2.00750632
14MAPK111.97376848
15BRD41.92714723
16FLT31.89568397
17MAP4K11.89323216
18ACVR1B1.87982327
19PIK3CG1.83761468
20TYK21.72446897
21LATS11.69007465
22PIK3CA1.66841052
23TRIB31.58721822
24DAPK21.50904366
25ABL21.43318535
26SIK21.40792899
27PTK61.40769978
28NEK91.38032558
29FGFR21.35705056
30TNK21.35618334
31MAP4K21.31544966
32KDR1.29688647
33DYRK1A1.26628480
34MELK1.25359637
35FRK1.25304111
36TXK1.24942924
37JAK21.23489433
38ADRBK21.22912453
39MAP3K71.22077801
40WNK41.18299694
41PRKAA21.14886358
42PINK11.14556667
43MAPK151.10850924
44ERBB21.09258936
45GRK61.06998355
46CAMKK21.06068887
47BMPR1B1.05578894
48CAMKK11.04282044
49NTRK31.04192193
50MAP2K31.02509224
51TBK11.01728438
52JAK11.00313173
53MAPK40.99815858
54MAP3K140.95436303
55PRPF4B0.94859708
56STK38L0.93486625
57PRKCZ0.93028027
58MAP3K100.92560448
59MAP3K30.87781774
60EPHB10.85154202
61SGK10.84785567
62EPHA30.83351928
63MET0.82449332
64DYRK30.81935308
65STK110.81514816
66MAPK120.80602788
67CDK60.78927247
68SMG10.78104994
69TIE10.75684385
70PRKACG0.75630632
71CAMK2G0.75238842
72MAP3K110.74091960
73STK380.74032873
74CSNK1D0.72775342
75DYRK1B0.71642279
76TAF10.70771820
77PRKG10.70492407
78CSK0.69076275
79GSK3A0.68716744
80ZAP700.68321440
81PRKAA10.67207959
82MAP2K60.66754111
83CAMK1D0.65545470
84SGK30.62140124
85BLK0.61618247
86NUAK10.61135051
87WNK30.60386334
88MAPK70.59942623
89IRAK30.59496072
90SYK0.58391415
91FGFR30.57974932
92CHUK0.57777492
93PRKACA0.57360692
94WNK10.56862795
95EPHA40.56264748
96MAP2K20.55819239
97IKBKE0.54142948
98TGFBR20.54068839
99PTK20.52933707
100CSNK1G10.52050409
101CSF1R0.52012304
102ICK0.51414834
103RPS6KA30.51377240
104IKBKB0.50976816
105PRKCQ0.50528605
106RIPK10.49893515
107HIPK20.49710297
108STK160.48851549
109PDK20.48799193
110PKN10.48745980
111PDPK10.47811572
112DYRK20.47356817
113OBSCN0.47199791
114MUSK0.46678745
115MAP3K20.46216245
116ADRBK10.46209645
117SGK20.45997770
118TAOK20.45740481
119GRK10.45321754
120ITK0.44349266
121MAP3K130.44119546
122IGF1R0.42072767
123PRKCG0.41515279
124CDK40.40655251
125MAP3K50.40184031
126MAP3K60.39121652
127MAP2K10.38106994
128RET0.37680968
129PBK0.37405977
130MTOR0.36876162
131EGFR0.33399933
132CAMK40.32766994
133SGK2230.31983729
134SGK4940.31983729
135CSNK1G20.29525660
136MAP3K10.28853061
137CSNK1G30.27818771
138PDK10.26949022
139PRKCA0.26005621
140AKT30.25229502
141LATS20.24925649
142PAK30.22432547
143ABL10.22349123
144IRAK10.21927694
145IRAK20.21683638
146CSNK1A1L0.19976960
147CAMK1G0.19674603
148MAPK30.19044840

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.59105086
2Nitrogen metabolism_Homo sapiens_hsa009103.57310992
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40262728
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33813159
5Arginine biosynthesis_Homo sapiens_hsa002203.08131820
6* Complement and coagulation cascades_Homo sapiens_hsa046102.75067399
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71135809
8Tryptophan metabolism_Homo sapiens_hsa003802.70570952
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62805900
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55858000
11Fatty acid degradation_Homo sapiens_hsa000712.47306289
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37131146
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24563115
14Butanoate metabolism_Homo sapiens_hsa006502.14242913
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13104920
16Peroxisome_Homo sapiens_hsa041462.08400881
17Chemical carcinogenesis_Homo sapiens_hsa052041.95108761
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.94943473
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91905998
20Histidine metabolism_Homo sapiens_hsa003401.91409908
21Propanoate metabolism_Homo sapiens_hsa006401.90376698
22PPAR signaling pathway_Homo sapiens_hsa033201.86561767
23Fatty acid metabolism_Homo sapiens_hsa012121.80301747
24Caffeine metabolism_Homo sapiens_hsa002321.79836294
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77185394
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74959952
27Retinol metabolism_Homo sapiens_hsa008301.71333732
28beta-Alanine metabolism_Homo sapiens_hsa004101.69653427
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66463625
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59732612
31Selenocompound metabolism_Homo sapiens_hsa004501.59660745
32* Staphylococcus aureus infection_Homo sapiens_hsa051501.58712821
33Phenylalanine metabolism_Homo sapiens_hsa003601.56662277
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52223707
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51974915
36Bile secretion_Homo sapiens_hsa049761.49727345
37Tyrosine metabolism_Homo sapiens_hsa003501.45509095
38Pyruvate metabolism_Homo sapiens_hsa006201.36212110
39Fatty acid elongation_Homo sapiens_hsa000621.33994233
40Sulfur metabolism_Homo sapiens_hsa009201.33174101
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32028896
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28058645
43Steroid biosynthesis_Homo sapiens_hsa001001.23124705
44Folate biosynthesis_Homo sapiens_hsa007901.20969973
45ABC transporters_Homo sapiens_hsa020101.20873049
46Biosynthesis of amino acids_Homo sapiens_hsa012301.20390092
47Fat digestion and absorption_Homo sapiens_hsa049751.15249436
48Carbon metabolism_Homo sapiens_hsa012001.11169348
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05455339
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.04484475
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98626923
52Vitamin B6 metabolism_Homo sapiens_hsa007500.97460391
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97451113
54Sulfur relay system_Homo sapiens_hsa041220.96783866
55Arginine and proline metabolism_Homo sapiens_hsa003300.96723763
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88284539
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84146955
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83341109
59Lysine degradation_Homo sapiens_hsa003100.82015849
60One carbon pool by folate_Homo sapiens_hsa006700.78506711
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69166051
62Glycerolipid metabolism_Homo sapiens_hsa005610.67293675
63Glutathione metabolism_Homo sapiens_hsa004800.63569570
64Pentose phosphate pathway_Homo sapiens_hsa000300.55800847
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54697043
66Metabolic pathways_Homo sapiens_hsa011000.46452954
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44832126
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40098495
69Prion diseases_Homo sapiens_hsa050200.38827747
70Pertussis_Homo sapiens_hsa051330.31158456
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26402964
72Galactose metabolism_Homo sapiens_hsa000520.25726428
73Fructose and mannose metabolism_Homo sapiens_hsa000510.23608685
74Insulin resistance_Homo sapiens_hsa049310.23281778
75Linoleic acid metabolism_Homo sapiens_hsa005910.22918797
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21777130
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20035429
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.17061792
79Glucagon signaling pathway_Homo sapiens_hsa049220.11320025
80Circadian rhythm_Homo sapiens_hsa047100.06621161
81Other glycan degradation_Homo sapiens_hsa005110.05781284
82Serotonergic synapse_Homo sapiens_hsa047260.04756968
83AMPK signaling pathway_Homo sapiens_hsa041520.02173339
84Amoebiasis_Homo sapiens_hsa05146-0.2466285
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2396257
86Ether lipid metabolism_Homo sapiens_hsa00565-0.2394783
87Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2392254
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2293568
89GABAergic synapse_Homo sapiens_hsa04727-0.2137895
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1977946
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1950679
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1931104
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1922266
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1916176
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1821046
96Hepatitis C_Homo sapiens_hsa05160-0.1806431
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1674191
98FoxO signaling pathway_Homo sapiens_hsa04068-0.1638488
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1619652
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1553146
101African trypanosomiasis_Homo sapiens_hsa05143-0.1407737
102Sphingolipid metabolism_Homo sapiens_hsa00600-0.1322303
103Regulation of autophagy_Homo sapiens_hsa04140-0.1267503
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1199105
105Type II diabetes mellitus_Homo sapiens_hsa04930-0.1055724
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0990828
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0709972
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0618969
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0543028
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0418099
111Mineral absorption_Homo sapiens_hsa04978-0.0060867

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