MARVELD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)7.20985228
2glomerular epithelial cell development (GO:0072310)6.38499653
3glomerular basement membrane development (GO:0032836)5.98305706
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.62965550
5bone trabecula formation (GO:0060346)4.40026222
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.22855478
7protein heterotrimerization (GO:0070208)4.07092307
8COPI coating of Golgi vesicle (GO:0048205)4.05022184
9Golgi transport vesicle coating (GO:0048200)4.05022184
10protein retention in ER lumen (GO:0006621)4.02329555
11cell migration involved in heart development (GO:0060973)4.01969382
12positive regulation of p38MAPK cascade (GO:1900745)3.95619862
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.88222000
14vascular endothelial growth factor signaling pathway (GO:0038084)3.79949982
15cell adhesion mediated by integrin (GO:0033627)3.78412798
16surfactant homeostasis (GO:0043129)3.75954605
17negative regulation of chondrocyte differentiation (GO:0032331)3.70620711
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.65312880
19apoptotic cell clearance (GO:0043277)3.60210163
20adherens junction assembly (GO:0034333)3.53897809
21Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.53226415
22barbed-end actin filament capping (GO:0051016)3.52550514
23virion attachment to host cell (GO:0019062)3.48683695
24adhesion of symbiont to host cell (GO:0044650)3.48683695
25positive regulation of fatty acid beta-oxidation (GO:0032000)3.45929256
26type B pancreatic cell proliferation (GO:0044342)3.45497441
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.42814589
28negative regulation of fibrinolysis (GO:0051918)3.41594969
29extracellular fibril organization (GO:0043206)3.41279824
30cell-substrate adherens junction assembly (GO:0007045)3.40839549
31focal adhesion assembly (GO:0048041)3.40839549
32sequestering of extracellular ligand from receptor (GO:0035581)3.39748349
33adhesion of symbiont to host (GO:0044406)3.38496632
34endothelial cell chemotaxis (GO:0035767)3.34305182
35extracellular matrix assembly (GO:0085029)3.33794586
36regulation of establishment of planar polarity (GO:0090175)3.33582856
37substrate-dependent cell migration (GO:0006929)3.31704330
38peptidyl-glutamic acid carboxylation (GO:0017187)3.26867515
39protein carboxylation (GO:0018214)3.26867515
40collagen fibril organization (GO:0030199)3.21613993
41desmosome organization (GO:0002934)3.21306726
42basement membrane organization (GO:0071711)3.20900110
43regulation of p38MAPK cascade (GO:1900744)3.20867650
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19352099
45heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.18533833
46endodermal cell differentiation (GO:0035987)3.13792517
47regulation of fatty acid beta-oxidation (GO:0031998)3.11945440
48regulation of early endosome to late endosome transport (GO:2000641)3.11516819
49cell migration involved in sprouting angiogenesis (GO:0002042)3.10494543
50epoxygenase P450 pathway (GO:0019373)3.07353727
51low-density lipoprotein particle clearance (GO:0034383)3.06069284
52alpha-linolenic acid metabolic process (GO:0036109)3.05413405
53cellular response to vitamin (GO:0071295)3.04971954
54fibril organization (GO:0097435)3.00821826
55cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.00083491
56semaphorin-plexin signaling pathway (GO:0071526)2.99807781
57complement activation, alternative pathway (GO:0006957)2.99472138
58positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.97510785
59atrioventricular valve morphogenesis (GO:0003181)2.97414782
60convergent extension (GO:0060026)2.97312380
61epithelial cell-cell adhesion (GO:0090136)2.96508851
62renal filtration (GO:0097205)2.93604689
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91756929
64growth hormone receptor signaling pathway (GO:0060396)2.91446043
65positive regulation of histone deacetylation (GO:0031065)2.90184282
66tooth mineralization (GO:0034505)2.87942596
67negative regulation of smooth muscle cell migration (GO:0014912)2.87777829
68positive regulation of fatty acid oxidation (GO:0046321)2.87468056
69non-canonical Wnt signaling pathway (GO:0035567)2.87054503
70peptidyl-proline hydroxylation (GO:0019511)2.86146364
71blood vessel endothelial cell migration (GO:0043534)2.85568522
72regulation of fibrinolysis (GO:0051917)2.84704662
73regulation of protein activation cascade (GO:2000257)2.84329865
74glomerulus development (GO:0032835)2.83827902
75cellular response to vitamin D (GO:0071305)2.83437660
76lung vasculature development (GO:0060426)2.83426903
77regulation of complement activation (GO:0030449)2.82981257
78cochlea morphogenesis (GO:0090103)2.82616363
79wound healing, spreading of epidermal cells (GO:0035313)2.82289991
80regulation of cholesterol homeostasis (GO:2000188)2.81642224
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.81121046
82muscle cell migration (GO:0014812)2.80074951
83hyaluronan catabolic process (GO:0030214)2.79143211
84extracellular matrix organization (GO:0030198)2.78989010
85chondrocyte development (GO:0002063)2.78844981
86regulation of endothelial cell chemotaxis (GO:2001026)2.78626556
87extracellular structure organization (GO:0043062)2.77771565
88glial cell migration (GO:0008347)2.76218171
89paraxial mesoderm development (GO:0048339)2.75431952
90negative regulation of cartilage development (GO:0061037)2.74938534
91wound healing, spreading of cells (GO:0044319)2.74859680
92hypotonic response (GO:0006971)2.74479927
93skin morphogenesis (GO:0043589)2.74338146
94positive regulation of osteoblast proliferation (GO:0033690)2.73418272
95fibrinolysis (GO:0042730)2.72001940
96chemical homeostasis within a tissue (GO:0048875)2.70192412
97valine metabolic process (GO:0006573)2.69691291
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69383368
99L-phenylalanine metabolic process (GO:0006558)2.69383368
100endothelial cell morphogenesis (GO:0001886)2.68440819
101hemidesmosome assembly (GO:0031581)2.68316301
102negative regulation of fatty acid transport (GO:2000192)2.68233057
103retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67718920
104coronary vasculature morphogenesis (GO:0060977)2.67146080
105blood vessel maturation (GO:0001955)2.67066098
106negative regulation of cell size (GO:0045792)2.66207336
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.65725611
108sulfur amino acid catabolic process (GO:0000098)2.64054333
109regulation of plasminogen activation (GO:0010755)2.63660359
110protein hydroxylation (GO:0018126)2.63514626
111establishment of apical/basal cell polarity (GO:0035089)2.63508716
112mesodermal cell differentiation (GO:0048333)2.62424062
113mesenchymal-epithelial cell signaling (GO:0060638)2.60415888
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.60302153
115multicellular organismal macromolecule metabolic process (GO:0044259)2.60225797
116trabecula formation (GO:0060343)2.59057410
117collagen metabolic process (GO:0032963)2.58456455
118heparan sulfate proteoglycan metabolic process (GO:0030201)2.57830922
119L-phenylalanine catabolic process (GO:0006559)2.57422987
120erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57422987
121cell-substrate junction assembly (GO:0007044)2.57252107
122lysine metabolic process (GO:0006553)2.57132706
123lysine catabolic process (GO:0006554)2.57132706
124kidney mesenchyme development (GO:0072074)2.56502148
125UV protection (GO:0009650)2.55768454
126chondrocyte proliferation (GO:0035988)2.55719805
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53849268
128stress fiber assembly (GO:0043149)2.53685374
129collagen catabolic process (GO:0030574)2.52836642
130regulation of extracellular matrix disassembly (GO:0010715)2.52689119
131G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52628646
132pinocytosis (GO:0006907)2.52528401
133cellular response to growth hormone stimulus (GO:0071378)2.52435765
134multicellular organismal catabolic process (GO:0044243)2.51897270
135protein maturation by protein folding (GO:0022417)2.51442711
136fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.51004306
137regulation of fatty acid oxidation (GO:0046320)2.50756040
138regulation of cholesterol storage (GO:0010885)2.50460004
139metanephric mesenchyme development (GO:0072075)2.49564513
140multicellular organismal metabolic process (GO:0044236)2.48656409
141lymphangiogenesis (GO:0001946)2.48131655
142fatty acid transmembrane transport (GO:1902001)2.47025381
143venous blood vessel morphogenesis (GO:0048845)2.44432298
144positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44248582
145positive regulation of lipid catabolic process (GO:0050996)2.43593975
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41635285
147fatty acid beta-oxidation (GO:0006635)2.41321862
148plasma lipoprotein particle clearance (GO:0034381)2.38962941
1494-hydroxyproline metabolic process (GO:0019471)2.38531062
150antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38227644
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38227644
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.37053829
153axon extension involved in axon guidance (GO:0048846)2.35684881
154neuron projection extension involved in neuron projection guidance (GO:1902284)2.35684881
155extracellular matrix disassembly (GO:0022617)2.34197291
156branching involved in salivary gland morphogenesis (GO:0060445)2.33266181
157glomerular filtration (GO:0003094)2.33035256
158substrate adhesion-dependent cell spreading (GO:0034446)2.31316638
159protein localization to endosome (GO:0036010)2.30594325
160plasma membrane repair (GO:0001778)2.28940142
161fatty acid oxidation (GO:0019395)2.27857281
162negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.26370231
163response to fluid shear stress (GO:0034405)2.25992349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.92158110
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.86988595
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78019551
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.75077497
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.61887618
6* CLOCK_20551151_ChIP-Seq_293T_Human3.41818929
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29920919
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.24866190
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.08709541
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89357362
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67198973
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37395306
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35406705
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.32911627
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27752754
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.27456228
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26397496
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.08400620
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03766296
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00305162
21* ELK3_25401928_ChIP-Seq_HUVEC_Human1.91086776
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88256116
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87752271
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82893234
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81305573
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78829351
27TP53_22127205_ChIP-Seq_IMR90_Human1.75124173
28VDR_21846776_ChIP-Seq_THP-1_Human1.70876163
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.69025816
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67198529
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.64950209
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.64054275
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63567705
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63396826
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61440123
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61230649
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61111540
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55372965
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.51527840
40ZNF263_19887448_ChIP-Seq_K562_Human1.50940010
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50293627
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.48508150
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.48508150
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.48249853
45LXR_22292898_ChIP-Seq_THP-1_Human1.48081483
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46430775
47* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46324019
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43062219
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41827369
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40363016
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.38432065
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37455917
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37444462
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34654613
55CJUN_26792858_Chip-Seq_BT549_Human1.34531698
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34056197
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32966572
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.30917124
59* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30118034
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30055650
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29648049
62* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29588338
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.29332456
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29272854
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28467580
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28107130
67ATF3_27146783_Chip-Seq_COLON_Human1.26062185
68* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23953696
69* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23953696
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.23519682
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23144342
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22317344
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21997197
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.21967261
75* KDM2B_26808549_Chip-Seq_DND41_Human1.21945607
76TCF7_22412390_ChIP-Seq_EML_Mouse1.21460343
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21424822
78GATA1_22025678_ChIP-Seq_K562_Human1.21268232
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.19938285
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19779634
81BRD4_25478319_ChIP-Seq_HGPS_Human1.18683156
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18625247
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16767338
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.16072229
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14371351
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14367982
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14355148
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.13805692
89* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13412451
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12906020
91MYC_22102868_ChIP-Seq_BL_Human1.11767090
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11536654
93* SOX2_20726797_ChIP-Seq_SW620_Human1.11360267
94* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10893946
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10716866
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.10700996
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10275415
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.10086818
99TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09440658
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08344311
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08298712
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08225005
103* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06919113
104KDM2B_26808549_Chip-Seq_K562_Human1.05699572
105* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05276726
106* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05121286
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.04553432
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03237943
109NCOR1_26117541_ChIP-Seq_K562_Human1.02575449
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02314957
111GATA4_25053715_ChIP-Seq_YYC3_Human1.01975561
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01791803
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.01261028
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01194157
115CDX2_20551321_ChIP-Seq_CACO-2_Human1.01088806
116* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00455281
117* SA1_22415368_ChIP-Seq_MEFs_Mouse1.00322931
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99536995
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98409031
120* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97299530
121* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97252084
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96731922
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.96377133
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96229945
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94771936
126EED_16625203_ChIP-ChIP_MESCs_Mouse0.94317776
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94290792
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94138137
129* CREB1_26743006_Chip-Seq_LNCaP_Human0.93596043
130* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92906234
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92218919
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92129096
133GATA1_19941826_ChIP-Seq_K562_Human0.91658537
134* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91478014
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90558100
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90536108
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90368825
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89942184
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88949002
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.88020031
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87706505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.29451656
2MP0003705_abnormal_hypodermis_morpholog3.77887724
3MP0005275_abnormal_skin_tensile2.94894748
4MP0010368_abnormal_lymphatic_system2.80022576
5MP0004272_abnormal_basement_membrane2.67492739
6MP0002139_abnormal_hepatobiliary_system2.43434053
7MP0005503_abnormal_tendon_morphology2.35149425
8MP0001958_emphysema2.32343440
9MP0003279_aneurysm2.25400085
10MP0003252_abnormal_bile_duct2.22821951
11MP0003566_abnormal_cell_adhesion2.16682324
12MP0005623_abnormal_meninges_morphology2.16115109
13MP0005360_urolithiasis2.07266122
14MP0005365_abnormal_bile_salt1.96400543
15MP0001879_abnormal_lymphatic_vessel1.85858501
16MP0001542_abnormal_bone_strength1.85505181
17MP0005085_abnormal_gallbladder_physiolo1.84481653
18MP0004858_abnormal_nervous_system1.77220239
19MP0004084_abnormal_cardiac_muscle1.74267195
20MP0009384_cardiac_valve_regurgitation1.66462958
21MP0003283_abnormal_digestive_organ1.63101364
22MP0003191_abnormal_cellular_cholesterol1.60794265
23MP0004185_abnormal_adipocyte_glucose1.60541898
24MP0010352_gastrointestinal_tract_polyps1.58386024
25MP0002060_abnormal_skin_morphology1.54865994
26MP0003941_abnormal_skin_development1.54724497
27MP0002138_abnormal_hepatobiliary_system1.54313247
28MP0000762_abnormal_tongue_morphology1.54206395
29MP0008875_abnormal_xenobiotic_pharmacok1.53273377
30MP0005023_abnormal_wound_healing1.52193423
31MP0009250_abnormal_appendicular_skeleto1.48679551
32MP0003300_gastrointestinal_ulcer1.45197276
33MP0005083_abnormal_biliary_tract1.41405956
34MP0000767_abnormal_smooth_muscle1.41383686
35MP0003091_abnormal_cell_migration1.41314254
36MP0010329_abnormal_lipoprotein_level1.38776026
37MP0009840_abnormal_foam_cell1.37650905
38MP0002295_abnormal_pulmonary_circulatio1.34606341
39MP0005670_abnormal_white_adipose1.33785506
40MP0002877_abnormal_melanocyte_morpholog1.32910950
41MP0003950_abnormal_plasma_membrane1.27140465
42MP0006054_spinal_hemorrhage1.27082837
43MP0003385_abnormal_body_wall1.26639182
44MP0005409_darkened_coat_color1.26442668
45MP0004130_abnormal_muscle_cell1.22840900
46MP0005666_abnormal_adipose_tissue1.21254648
47MP0010030_abnormal_orbit_morphology1.17688423
48MP0005171_absent_coat_pigmentation1.15611201
49MP0001299_abnormal_eye_distance/1.15466663
50MP0000428_abnormal_craniofacial_morphol1.15082069
51MP0005058_abnormal_lysosome_morphology1.14765726
52MP0009643_abnormal_urine_homeostasis1.13999371
53MP0005332_abnormal_amino_acid1.13651072
54MP0005197_abnormal_uvea_morphology1.12164440
55MP0009053_abnormal_anal_canal1.11470718
56MP0000467_abnormal_esophagus_morphology1.10719353
57MP0005508_abnormal_skeleton_morphology1.08462516
58MP0002128_abnormal_blood_circulation1.08374567
59MP0002896_abnormal_bone_mineralization1.05924701
60MP0006138_congestive_heart_failure1.03764936
61MP0009379_abnormal_foot_pigmentation1.03740077
62MP0000579_abnormal_nail_morphology1.03305390
63MP0004233_abnormal_muscle_weight1.02530719
64MP0002837_dystrophic_cardiac_calcinosis1.01509956
65MP0005375_adipose_tissue_phenotype1.01503393
66MP0005167_abnormal_blood-brain_barrier1.01062219
67MP0000609_abnormal_liver_physiology1.00674837
68MP0002254_reproductive_system_inflammat0.99666034
69MP0001243_abnormal_dermal_layer0.98715344
70MP0000049_abnormal_middle_ear0.98592513
71MP0000462_abnormal_digestive_system0.97690201
72MP0000013_abnormal_adipose_tissue0.96730075
73MP0002932_abnormal_joint_morphology0.95741015
74MP0004036_abnormal_muscle_relaxation0.95495565
75MP0010630_abnormal_cardiac_muscle0.95371677
76MP0000534_abnormal_ureter_morphology0.95167754
77MP0003755_abnormal_palate_morphology0.95092062
78MP0002249_abnormal_larynx_morphology0.94867077
79MP0003724_increased_susceptibility_to0.94824183
80MP0000733_abnormal_muscle_development0.93730475
81MP0005501_abnormal_skin_physiology0.93216374
82MP0005595_abnormal_vascular_smooth0.93206572
83MP0001756_abnormal_urination0.92617980
84MP0002118_abnormal_lipid_homeostasis0.92453986
85MP0002166_altered_tumor_susceptibility0.91901113
86MP0005319_abnormal_enzyme/_coenzyme0.91405561
87MP0001348_abnormal_lacrimal_gland0.91257892
88MP0002136_abnormal_kidney_physiology0.91214950
89MP0002933_joint_inflammation0.90327733
90MP0002135_abnormal_kidney_morphology0.89949633
91MP0001614_abnormal_blood_vessel0.89895483
92MP0005385_cardiovascular_system_phenoty0.89182687
93MP0001544_abnormal_cardiovascular_syste0.89182687
94MP0002113_abnormal_skeleton_development0.88997737
95MP0002168_other_aberrant_phenotype0.88878554
96MP0000759_abnormal_skeletal_muscle0.88828540
97MP0005076_abnormal_cell_differentiation0.88544320
98MP0003115_abnormal_respiratory_system0.88146814
99MP0010234_abnormal_vibrissa_follicle0.87543961
100MP0000432_abnormal_head_morphology0.87266040
101MP0005193_abnormal_anterior_eye0.85075843
102MP0009278_abnormal_bone_marrow0.84627786
103MP0008775_abnormal_heart_ventricle0.84488947
104MP0003045_fibrosis0.84233131
105MP0000003_abnormal_adipose_tissue0.84097456
106MP0002998_abnormal_bone_remodeling0.84049033
107MP0000537_abnormal_urethra_morphology0.83735936
108MP0003453_abnormal_keratinocyte_physiol0.82155122
109MP0005330_cardiomyopathy0.80948853
110MP0003942_abnormal_urinary_system0.79865528
111MP0002114_abnormal_axial_skeleton0.79775282
112MP0002116_abnormal_craniofacial_bone0.79554113
113MP0004087_abnormal_muscle_fiber0.79240101
114MP0000343_altered_response_to0.78957478
115MP0002796_impaired_skin_barrier0.78206243
116MP0001533_abnormal_skeleton_physiology0.77994183
117MP0002115_abnormal_skeleton_extremities0.77590308
118MP0000858_altered_metastatic_potential0.76784198
119MP0004510_myositis0.76638548
120MP0010771_integument_phenotype0.76116704
121MP0001915_intracranial_hemorrhage0.76072754
122MP0000751_myopathy0.76027007
123MP0004782_abnormal_surfactant_physiolog0.75992453
124MP0000249_abnormal_blood_vessel0.75575803
125MP0003828_pulmonary_edema0.75569008
126MP0001849_ear_inflammation0.75563063
127MP0000750_abnormal_muscle_regeneration0.75289490
128MP0000598_abnormal_liver_morphology0.75129339
129MP0005257_abnormal_intraocular_pressure0.74974687
130MP0005390_skeleton_phenotype0.74782171
131MP0005367_renal/urinary_system_phenotyp0.74646115
132MP0000516_abnormal_urinary_system0.74646115
133MP0000163_abnormal_cartilage_morphology0.74174397
134MP0002108_abnormal_muscle_morphology0.73554229
135MP0009780_abnormal_chondrocyte_physiolo0.73450863
136MP0001661_extended_life_span0.72963954
137MP0002089_abnormal_postnatal_growth/wei0.72776221
138MP0003935_abnormal_craniofacial_develop0.72744478
139MP0002925_abnormal_cardiovascular_devel0.72475752
140MP0002697_abnormal_eye_size0.72255577
141MP0000678_abnormal_parathyroid_gland0.70533459
142MP0004134_abnormal_chest_morphology0.69583680
143MP0003448_altered_tumor_morphology0.66436788
144MP0001216_abnormal_epidermal_layer0.64408077
145MP0002092_abnormal_eye_morphology0.61436318
146MP0001175_abnormal_lung_morphology0.60764232
147MP0008260_abnormal_autophagy0.60545117

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.20030728
2Premature rupture of membranes (HP:0001788)4.48834306
3Ankle contracture (HP:0006466)4.38163513
4Mesangial abnormality (HP:0001966)4.24685564
5Deep venous thrombosis (HP:0002625)4.18932896
6Vascular tortuosity (HP:0004948)3.91125972
7Focal segmental glomerulosclerosis (HP:0000097)3.72313609
8Broad metatarsal (HP:0001783)3.71134946
9Cerebral aneurysm (HP:0004944)3.70468234
10Peritonitis (HP:0002586)3.67061360
11Arterial tortuosity (HP:0005116)3.59702876
12Abnormality of dentin (HP:0010299)3.55716784
13Aortic dissection (HP:0002647)3.55703084
14Aortic aneurysm (HP:0004942)3.38621758
15Increased connective tissue (HP:0009025)3.32329921
16Shallow orbits (HP:0000586)3.31349817
17Glomerulosclerosis (HP:0000096)3.04805727
18Atrophic scars (HP:0001075)3.01242308
19Nephritis (HP:0000123)2.98283189
20Hematochezia (HP:0002573)2.89057078
21Mitral valve prolapse (HP:0001634)2.81317453
22Polycythemia (HP:0001901)2.77533402
23Lymphangioma (HP:0100764)2.76335078
24Xanthomatosis (HP:0000991)2.75920550
25Aneurysm (HP:0002617)2.74332142
26Spondylolisthesis (HP:0003302)2.72531757
27Type 1 muscle fiber predominance (HP:0003803)2.71082461
28Joint laxity (HP:0001388)2.67314084
29Cervical subluxation (HP:0003308)2.66540159
30Myocardial infarction (HP:0001658)2.66070459
31Abnormal albumin level (HP:0012116)2.64001816
32Hypoalbuminemia (HP:0003073)2.64001816
33Mitral regurgitation (HP:0001653)2.61557749
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.54120000
35Osteolytic defects of the hand bones (HP:0009699)2.54120000
36Esophageal varix (HP:0002040)2.49267912
37Bowel diverticulosis (HP:0005222)2.48454003
38Dilatation of the ascending aorta (HP:0005111)2.45923264
39Ulnar bowing (HP:0003031)2.45603934
40Glomerulonephritis (HP:0000099)2.44157556
41Spinal rigidity (HP:0003306)2.43372539
42Fragile skin (HP:0001030)2.42207192
43Complement deficiency (HP:0004431)2.40941714
44Aortic regurgitation (HP:0001659)2.40788639
45Short nail (HP:0001799)2.39295331
46Interstitial pulmonary disease (HP:0006530)2.38253753
47Right ventricular cardiomyopathy (HP:0011663)2.37244389
48Follicular hyperkeratosis (HP:0007502)2.29588020
49Natal tooth (HP:0000695)2.28854341
50Soft skin (HP:0000977)2.21522071
51Bladder diverticulum (HP:0000015)2.21150704
52Camptodactyly of toe (HP:0001836)2.20433753
53Long toe (HP:0010511)2.20401920
54Blue sclerae (HP:0000592)2.20275632
55Ectopia lentis (HP:0001083)2.19454453
56Hyperacusis (HP:0010780)2.18555611
57Achilles tendon contracture (HP:0001771)2.18113186
58Coronal craniosynostosis (HP:0004440)2.17811799
59Visceral angiomatosis (HP:0100761)2.17688569
60Overgrowth (HP:0001548)2.15809610
61Joint stiffness (HP:0001387)2.14085312
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13705909
63Wormian bones (HP:0002645)2.11154514
64Wide anterior fontanel (HP:0000260)2.10928704
65Delayed cranial suture closure (HP:0000270)2.10436600
66Abnormality of the peritoneum (HP:0002585)2.09685071
67Increased variability in muscle fiber diameter (HP:0003557)2.08694618
68Abnormality of the common coagulation pathway (HP:0010990)2.08459242
69Intrahepatic cholestasis (HP:0001406)2.07742028
70Bowed forearm bones (HP:0003956)2.05086686
71Bowing of the arm (HP:0006488)2.05086686
72Vertebral compression fractures (HP:0002953)2.04135323
73Breech presentation (HP:0001623)2.03111921
74Hemangiomatosis (HP:0007461)2.02969086
75Turricephaly (HP:0000262)2.02945112
76Hyperlipoproteinemia (HP:0010980)2.02824203
77Hypoglycemic coma (HP:0001325)2.00678011
78Trismus (HP:0000211)1.99928900
79Rectal prolapse (HP:0002035)1.99843530
80Premature skin wrinkling (HP:0100678)1.98975218
81Abnormality of complement system (HP:0005339)1.98591600
82Generalized amyotrophy (HP:0003700)1.98254447
83Skin nodule (HP:0200036)1.95970608
84Mildly elevated creatine phosphokinase (HP:0008180)1.94720062
85Hypoventilation (HP:0002791)1.94294898
86Persistence of primary teeth (HP:0006335)1.93425997
87Coxa vara (HP:0002812)1.93300769
88Aortic valve stenosis (HP:0001650)1.92154985
89Deviation of the hallux (HP:0010051)1.92094639
90Venous abnormality (HP:0002624)1.91271454
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91053269
92Hypoalphalipoproteinemia (HP:0003233)1.91052975
93Radial bowing (HP:0002986)1.90700479
94Spontaneous hematomas (HP:0007420)1.90632276
95Wrist flexion contracture (HP:0001239)1.90178291
96Renal duplication (HP:0000075)1.90027525
97Genu recurvatum (HP:0002816)1.89954501
98Neonatal respiratory distress (HP:0002643)1.88977157
99Biconcave vertebral bodies (HP:0004586)1.88807724
100Hallux valgus (HP:0001822)1.88166975
101Hyporeflexia of lower limbs (HP:0002600)1.87762094
102Inguinal hernia (HP:0000023)1.87612372
103Round ear (HP:0100830)1.87567123
104Elbow flexion contracture (HP:0002987)1.86048501
105Knee flexion contracture (HP:0006380)1.85463252
106Neonatal short-limb short stature (HP:0008921)1.84627656
107Spinal cord lesions (HP:0100561)1.84298392
108Syringomyelia (HP:0003396)1.84298392
109Abnormality of skeletal muscle fiber size (HP:0012084)1.84281167
110Abnormality of the nasal mucosa (HP:0000433)1.83831742
111Slender build (HP:0001533)1.82626222
112Mitral stenosis (HP:0001718)1.82423971
113Abnormal cartilage morphology (HP:0002763)1.82423392
114Abnormality of the Achilles tendon (HP:0005109)1.82137526
115Abnormality of the intrinsic pathway (HP:0010989)1.81939222
116Abnormality of the distal phalanges of the toes (HP:0010182)1.81426841
117Distal lower limb amyotrophy (HP:0008944)1.81420777
118Nonimmune hydrops fetalis (HP:0001790)1.79809907
119Abnormality of skull ossification (HP:0002703)1.79369755
120Abnormal delivery (HP:0001787)1.78368338
121Congenital glaucoma (HP:0001087)1.78123930
122Increased mean platelet volume (HP:0011877)1.77870508
123Cupped ribs (HP:0000887)1.77789319
124Hydroxyprolinuria (HP:0003080)1.76126999
125Abnormality of proline metabolism (HP:0010907)1.76126999
126Abnormal ossification of hand bones (HP:0005921)1.75439589
127Absent frontal sinuses (HP:0002688)1.74393177
128Venous insufficiency (HP:0005293)1.73703097
129Hyperextensible skin (HP:0000974)1.73460221
130Distal lower limb muscle weakness (HP:0009053)1.72980246
131Abnormality of carpal bone ossification (HP:0006257)1.72880653
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72863634
133Chondrocalcinosis (HP:0000934)1.72230898
134Broad ribs (HP:0000885)1.71127073
135Broad face (HP:0000283)1.70332719
136Disproportionate tall stature (HP:0001519)1.69997249
137Muscle fiber splitting (HP:0003555)1.69674690
138Distal upper limb amyotrophy (HP:0007149)1.69674183
139Upper limb amyotrophy (HP:0009129)1.69674183
140Selective tooth agenesis (HP:0001592)1.69636168
141Thin bony cortex (HP:0002753)1.69035106
142Protruding ear (HP:0000411)1.68617515
143Mild short stature (HP:0003502)1.68332911
144Cardiovascular calcification (HP:0011915)1.68124274
145Flat cornea (HP:0007720)1.67328118
146Arachnodactyly (HP:0001166)1.67241340
147Asymmetry of the thorax (HP:0001555)1.66830500
148Alopecia of scalp (HP:0002293)1.66046899
149Abnormality of the acetabulum (HP:0003170)1.65971249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.49120700
2TTN3.57382638
3PKN23.20328414
4ERN13.19320704
5SIK12.61576854
6SMG12.52029831
7NTRK12.49085984
8TIE12.48530255
9RIPK12.45517026
10TGFBR22.43953450
11PDGFRA2.20550003
12MAP3K32.19302526
13EPHB22.12491370
14LATS12.07803174
15FGFR42.04573824
16DDR22.02325429
17TESK11.92105358
18MYLK1.90968052
19MAP2K31.81396954
20PTK61.81081775
21NME21.73690321
22PAK41.73105939
23BCKDK1.68566299
24EPHB11.68162987
25IRAK31.67484693
26LRRK21.61103498
27FLT31.56585072
28LIMK11.48474228
29CAMK1D1.39330733
30EEF2K1.37672785
31MAP3K21.33043490
32PRPF4B1.31814846
33BMX1.31466176
34PAK21.30822799
35KDR1.29044890
36MOS1.28757974
37EPHA31.25252510
38TAOK31.24180843
39ARAF1.22528948
40CDC42BPA1.21747814
41NEK91.21019286
42PIM21.20675707
43MAP3K101.19870594
44PRKD31.19482007
45PTK21.19115780
46MAP3K61.14843554
47JAK31.12943696
48FGFR21.09065978
49MET1.05196591
50CDK121.04296780
51MST1R1.03701290
52JAK11.03641219
53FGFR30.99669389
54FER0.99359925
55EPHA20.98017834
56DMPK0.97234216
57TGFBR10.96794317
58MTOR0.95996215
59PDGFRB0.95685529
60TRPM70.94000503
61CDK80.92543048
62TBK10.92305431
63LATS20.91517261
64FRK0.90530608
65TYK20.89452769
66STK380.89015671
67ZAP700.88756272
68PRKCH0.88058056
69ERBB40.84956407
70RET0.84893463
71RPS6KA40.84535115
72TAOK20.83552251
73CAMK1G0.81187427
74MAP3K70.78552032
75ILK0.78424546
76PIK3CG0.78056721
77STK100.77396380
78CDK60.77145273
79ROCK20.77070596
80GSK3A0.76372240
81STK30.74766000
82WNK40.74681495
83FGFR10.72702481
84PRKD20.72265289
85JAK20.65591341
86KIT0.64697448
87CSK0.61815947
88MELK0.61257779
89PTK2B0.60848266
90BRAF0.60731316
91CDK70.60313905
92MAP2K10.59804077
93MAPK70.59682129
94ROCK10.59674745
95CHUK0.57659993
96PRKAA20.56747020
97PAK10.56046880
98MAP2K20.55888599
99PRKD10.55687143
100LMTK20.55369994
101SCYL20.54292990
102STK38L0.52263522
103NEK20.51099561
104MAP4K10.51001260
105PIK3CA0.50882672
106MAPKAPK30.50814978
107MARK20.50446770
108MAP3K140.49707067
109PAK30.49223491
110KSR20.44035625
111CLK10.42636851
112INSRR0.42513217
113VRK20.41324515
114PRKG20.40834595
115RPS6KB20.40210733
116CSF1R0.39271950
117CDK90.38888705
118TESK20.38509625
119ICK0.37730557
120MAP3K80.37211902
121MAP3K10.37149502
122MAPK110.37098966
123DYRK1B0.37038032
124IKBKB0.35689116
125ABL20.34601067
126IGF1R0.34338301
127RPS6KA60.34295040
128HIPK20.33812786
129RPS6KC10.32758988
130RPS6KL10.32758988
131DAPK30.32592096
132PDPK10.31874970
133MAPKAPK20.31333163
134RPS6KA20.30652665
135MAP3K130.30348686
136AURKA0.28297197

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.74189087
2Nitrogen metabolism_Homo sapiens_hsa009102.49358627
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.48653856
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.47921410
5Fatty acid degradation_Homo sapiens_hsa000712.40917272
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40827698
7Complement and coagulation cascades_Homo sapiens_hsa046102.34650621
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19869701
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07610272
10Tryptophan metabolism_Homo sapiens_hsa003801.92656142
11Caffeine metabolism_Homo sapiens_hsa002321.92640614
12Focal adhesion_Homo sapiens_hsa045101.92571075
13Other glycan degradation_Homo sapiens_hsa005111.91141212
14PPAR signaling pathway_Homo sapiens_hsa033201.87649016
15Arginine biosynthesis_Homo sapiens_hsa002201.80664443
16Fatty acid metabolism_Homo sapiens_hsa012121.72215074
17Basal cell carcinoma_Homo sapiens_hsa052171.68268692
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64655318
19Propanoate metabolism_Homo sapiens_hsa006401.62501233
20Staphylococcus aureus infection_Homo sapiens_hsa051501.60459921
21Small cell lung cancer_Homo sapiens_hsa052221.55377561
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54861010
23Amoebiasis_Homo sapiens_hsa051461.52017244
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46588941
25Hedgehog signaling pathway_Homo sapiens_hsa043401.37837531
26Protein digestion and absorption_Homo sapiens_hsa049741.36744407
27Thyroid cancer_Homo sapiens_hsa052161.35222451
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33090214
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27944689
30Galactose metabolism_Homo sapiens_hsa000521.27871505
31Proteoglycans in cancer_Homo sapiens_hsa052051.27027723
32Melanoma_Homo sapiens_hsa052181.25688328
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24419763
34Bladder cancer_Homo sapiens_hsa052191.24327014
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21443611
36Pentose phosphate pathway_Homo sapiens_hsa000301.19051829
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18569587
38Adherens junction_Homo sapiens_hsa045201.17853807
39Lysine degradation_Homo sapiens_hsa003101.16837172
40Melanogenesis_Homo sapiens_hsa049161.15794900
41Insulin resistance_Homo sapiens_hsa049311.13371861
42Bile secretion_Homo sapiens_hsa049761.12485057
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.10794857
44Glioma_Homo sapiens_hsa052141.10651942
45Chemical carcinogenesis_Homo sapiens_hsa052041.07072421
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06490078
47Selenocompound metabolism_Homo sapiens_hsa004501.05275057
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03061694
49N-Glycan biosynthesis_Homo sapiens_hsa005101.02836538
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02776200
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02518683
52Axon guidance_Homo sapiens_hsa043601.02400515
53Dilated cardiomyopathy_Homo sapiens_hsa054141.02345317
54Endometrial cancer_Homo sapiens_hsa052131.00813060
55Butanoate metabolism_Homo sapiens_hsa006500.99637894
56Peroxisome_Homo sapiens_hsa041460.98239277
57beta-Alanine metabolism_Homo sapiens_hsa004100.97756519
58Phenylalanine metabolism_Homo sapiens_hsa003600.95437194
59VEGF signaling pathway_Homo sapiens_hsa043700.95078239
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94682582
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93841341
62Starch and sucrose metabolism_Homo sapiens_hsa005000.93363661
63Renal cell carcinoma_Homo sapiens_hsa052110.92322203
64Wnt signaling pathway_Homo sapiens_hsa043100.92078771
65Shigellosis_Homo sapiens_hsa051310.91560946
66Chronic myeloid leukemia_Homo sapiens_hsa052200.90796975
67Carbon metabolism_Homo sapiens_hsa012000.89358906
68Renin-angiotensin system_Homo sapiens_hsa046140.88801855
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.87169064
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85927552
71Non-small cell lung cancer_Homo sapiens_hsa052230.85622957
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.85172738
73Histidine metabolism_Homo sapiens_hsa003400.84798286
74ABC transporters_Homo sapiens_hsa020100.84719764
75Gap junction_Homo sapiens_hsa045400.84719624
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84666761
77p53 signaling pathway_Homo sapiens_hsa041150.84157885
78Colorectal cancer_Homo sapiens_hsa052100.83050610
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82990489
80Vibrio cholerae infection_Homo sapiens_hsa051100.82809101
81Toxoplasmosis_Homo sapiens_hsa051450.82103896
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80985233
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80433059
84Tight junction_Homo sapiens_hsa045300.80367163
85Retinol metabolism_Homo sapiens_hsa008300.78187219
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78105546
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75440825
88Platelet activation_Homo sapiens_hsa046110.75009106
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74952025
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.74927706
91Fat digestion and absorption_Homo sapiens_hsa049750.73176526
92Endocytosis_Homo sapiens_hsa041440.72674579
93Pyruvate metabolism_Homo sapiens_hsa006200.72595469
94Estrogen signaling pathway_Homo sapiens_hsa049150.71228716
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.70035672
96HTLV-I infection_Homo sapiens_hsa051660.69886138
97Fatty acid biosynthesis_Homo sapiens_hsa000610.68821371
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.68762447
99Tyrosine metabolism_Homo sapiens_hsa003500.67466356
100Viral myocarditis_Homo sapiens_hsa054160.67247426
101ErbB signaling pathway_Homo sapiens_hsa040120.65868704
102AMPK signaling pathway_Homo sapiens_hsa041520.64327410
103Malaria_Homo sapiens_hsa051440.63828179
104Biosynthesis of amino acids_Homo sapiens_hsa012300.62124949
105GnRH signaling pathway_Homo sapiens_hsa049120.62089368
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60219538
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.60022246
108MicroRNAs in cancer_Homo sapiens_hsa052060.58969468
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58436670
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58334179
111Pancreatic cancer_Homo sapiens_hsa052120.58236434
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58072347
113Sulfur relay system_Homo sapiens_hsa041220.57021919
114TGF-beta signaling pathway_Homo sapiens_hsa043500.56020503
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55352913
116Hepatitis B_Homo sapiens_hsa051610.55020049
117Acute myeloid leukemia_Homo sapiens_hsa052210.54650772
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54321282
119Sulfur metabolism_Homo sapiens_hsa009200.53512929
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52686724
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52579982
122TNF signaling pathway_Homo sapiens_hsa046680.51952144
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50852201
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50108125
125Salmonella infection_Homo sapiens_hsa051320.49954350
126Leishmaniasis_Homo sapiens_hsa051400.49213371
127Fructose and mannose metabolism_Homo sapiens_hsa000510.48379370
128Pathways in cancer_Homo sapiens_hsa052000.47372231
129Hippo signaling pathway_Homo sapiens_hsa043900.47054980
130mTOR signaling pathway_Homo sapiens_hsa041500.46908025
131Insulin signaling pathway_Homo sapiens_hsa049100.46584081
132Notch signaling pathway_Homo sapiens_hsa043300.46361258
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46180197
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.45423522
135Lysosome_Homo sapiens_hsa041420.45324796
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44432212
137Choline metabolism in cancer_Homo sapiens_hsa052310.43330433
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43091902
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42341878
140Sphingolipid metabolism_Homo sapiens_hsa006000.42172657
141Hepatitis C_Homo sapiens_hsa051600.42080073
142Rap1 signaling pathway_Homo sapiens_hsa040150.41913535
143Prostate cancer_Homo sapiens_hsa052150.41724145
144Prion diseases_Homo sapiens_hsa050200.40954347
145Arginine and proline metabolism_Homo sapiens_hsa003300.40175556
146Fatty acid elongation_Homo sapiens_hsa000620.39587621
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39445512
148Apoptosis_Homo sapiens_hsa042100.39086533
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38961749
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.38551064
151Ras signaling pathway_Homo sapiens_hsa040140.38239445
152Thyroid hormone synthesis_Homo sapiens_hsa049180.37509247

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