MARK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38167764
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.38167764
3modulation by symbiont of host immune response (GO:0052553)4.38167764
4positive regulation by symbiont of host defense response (GO:0052509)4.38167764
5modulation by symbiont of host defense response (GO:0052031)4.38167764
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38167764
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22576660
8positive regulation of histone deacetylation (GO:0031065)4.10740957
9cytoplasmic mRNA processing body assembly (GO:0033962)4.04869871
10response to peptidoglycan (GO:0032494)3.97696188
11detection of other organism (GO:0098543)3.80548576
12positive thymic T cell selection (GO:0045059)3.78897690
13macrophage activation involved in immune response (GO:0002281)3.77734915
14pre-miRNA processing (GO:0031054)3.74688294
15detection of bacterium (GO:0016045)3.73022183
16regulation of gamma-delta T cell differentiation (GO:0045586)3.72075474
17negative regulation of cell killing (GO:0031342)3.66706387
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66706387
19thymic T cell selection (GO:0045061)3.63551735
20positive regulation of gamma-delta T cell activation (GO:0046645)3.63047063
21intracellular estrogen receptor signaling pathway (GO:0030520)3.54782865
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.53039607
23negative regulation of histone methylation (GO:0031061)3.40793934
24neutrophil activation involved in immune response (GO:0002283)3.38596616
25regulation of gamma-delta T cell activation (GO:0046643)3.35296853
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32616733
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32616733
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.31130507
29peptidyl-tyrosine autophosphorylation (GO:0038083)3.30915405
30histone H3-K4 methylation (GO:0051568)3.28420980
31positive regulation of gene expression, epigenetic (GO:0045815)3.21874880
32negative thymic T cell selection (GO:0045060)3.19855377
33detection of external biotic stimulus (GO:0098581)3.18050124
34DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.17837332
35response to muramyl dipeptide (GO:0032495)3.14171497
36negative T cell selection (GO:0043383)3.13897759
37T cell selection (GO:0045058)3.13490690
38regulation of interferon-beta biosynthetic process (GO:0045357)3.12590305
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11312328
40positive regulation of protein deacetylation (GO:0090312)3.07079912
41positive T cell selection (GO:0043368)3.02790495
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00781625
43response to host immune response (GO:0052572)3.00781625
44glucocorticoid receptor signaling pathway (GO:0042921)3.00418461
45antigen processing and presentation via MHC class Ib (GO:0002475)2.99393306
46antigen processing and presentation of endogenous antigen (GO:0019883)2.98603551
47response to host (GO:0075136)2.97627335
48response to host defenses (GO:0052200)2.97627335
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97627335
50regulation of leukocyte degranulation (GO:0043300)2.96146958
51regulation of histone H3-K27 methylation (GO:0061085)2.95538774
52heterochromatin organization (GO:0070828)2.93531359
53regulation of B cell receptor signaling pathway (GO:0050855)2.91848895
54mitotic sister chromatid cohesion (GO:0007064)2.91302689
55detection of molecule of bacterial origin (GO:0032490)2.90767673
56histone H3-K4 trimethylation (GO:0080182)2.90721687
57corticosteroid receptor signaling pathway (GO:0031958)2.89686834
58trophectodermal cell differentiation (GO:0001829)2.87526836
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87097640
60germinal center formation (GO:0002467)2.87084543
61RNA stabilization (GO:0043489)2.86833012
62mRNA stabilization (GO:0048255)2.86833012
63DNA damage response, signal transduction resulting in transcription (GO:0042772)2.85597243
64signal complex assembly (GO:0007172)2.85344651
65regulation of T-helper 2 cell differentiation (GO:0045628)2.85011461
66response to laminar fluid shear stress (GO:0034616)2.83994700
67mannose metabolic process (GO:0006013)2.83565048
68regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82014006
69regulation of ARF protein signal transduction (GO:0032012)2.81361717
70neutrophil activation (GO:0042119)2.80682395
71regulation of clathrin-mediated endocytosis (GO:2000369)2.80623735
72activation of Rac GTPase activity (GO:0032863)2.80577533
73mitotic chromosome condensation (GO:0007076)2.80180535
74negative regulation of lymphocyte mediated immunity (GO:0002707)2.79064280
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.78749066
76peptidyl-lysine dimethylation (GO:0018027)2.77030491
77cellular extravasation (GO:0045123)2.76365908
78lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76148945
79histone H2A monoubiquitination (GO:0035518)2.74847307
80detection of biotic stimulus (GO:0009595)2.74566533
81positive regulation of lamellipodium organization (GO:1902745)2.74301659
82positive regulation of Rap GTPase activity (GO:0032854)2.73829518
83immunoglobulin mediated immune response (GO:0016064)2.73063120
84regulation of mast cell degranulation (GO:0043304)2.72751298
85negative regulation of stress fiber assembly (GO:0051497)2.72238689
86negative regulation of interleukin-12 production (GO:0032695)2.71639634
87negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70529035
883-UTR-mediated mRNA stabilization (GO:0070935)2.70101902
89positive regulation of lamellipodium assembly (GO:0010592)2.67381857
90granulocyte activation (GO:0036230)2.65137646
91regulation of macrophage cytokine production (GO:0010935)2.64933835
92regulation of hippo signaling (GO:0035330)2.64613674
93negative regulation of leukocyte mediated immunity (GO:0002704)2.64273616
94regulation of sister chromatid cohesion (GO:0007063)2.64080399
95NLS-bearing protein import into nucleus (GO:0006607)2.63461258
96negative regulation of cell size (GO:0045792)2.62091951
97regulation of regulated secretory pathway (GO:1903305)2.61941961
98response to type I interferon (GO:0034340)2.61598960
99cellular response to virus (GO:0098586)2.61481569
100positive regulation of macrophage cytokine production (GO:0060907)2.60800876
101modulation by symbiont of host cellular process (GO:0044068)2.59816637
102cellular response to type I interferon (GO:0071357)2.59431214
103type I interferon signaling pathway (GO:0060337)2.59431214
104modulation by virus of host process (GO:0019054)2.58850435
105regulation of RNA export from nucleus (GO:0046831)2.58077025
106gene silencing by RNA (GO:0031047)2.58069841
107sodium ion export (GO:0071436)2.57795890
108histone lysine methylation (GO:0034968)2.56888311
109NIK/NF-kappaB signaling (GO:0038061)2.56580619
110gene silencing (GO:0016458)2.55832786
111histone H3-K36 demethylation (GO:0070544)2.55097889
112histone H4-K12 acetylation (GO:0043983)2.55005756
113negative regulation of erythrocyte differentiation (GO:0045647)2.54547997
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53844518
115positive regulation of cellular amide metabolic process (GO:0034250)2.52609363
116respiratory burst (GO:0045730)2.52555449
117apoptotic process involved in morphogenesis (GO:0060561)2.52274696
118regulation of defense response to virus by virus (GO:0050690)2.51933521
119embryonic process involved in female pregnancy (GO:0060136)2.50033430
120activation of JUN kinase activity (GO:0007257)2.50026127
121regulation of necroptotic process (GO:0060544)2.49002553
122B cell receptor signaling pathway (GO:0050853)2.48787171
123regulation of T cell tolerance induction (GO:0002664)2.45611600
124regulation of early endosome to late endosome transport (GO:2000641)2.45374811
125regulation of ARF GTPase activity (GO:0032312)2.45253713
126production of molecular mediator involved in inflammatory response (GO:0002532)2.45136162
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44877310
128protein localization to endosome (GO:0036010)2.43760443
129macrophage activation (GO:0042116)2.43359863
130histone H4-K16 acetylation (GO:0043984)2.40654055
131regulation of nucleobase-containing compound transport (GO:0032239)2.40631999
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40213783
133myeloid leukocyte mediated immunity (GO:0002444)2.37775547
134negative regulation of T cell mediated immunity (GO:0002710)2.37512096
135regulation of mast cell activation involved in immune response (GO:0033006)2.37063800
136positive regulation of granulocyte differentiation (GO:0030854)2.36754573
137histone H3-K9 demethylation (GO:0033169)2.36322563
138positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36231227
139response to interleukin-15 (GO:0070672)2.36123393
140regulation of histone deacetylation (GO:0031063)2.35952989
141growth hormone receptor signaling pathway (GO:0060396)2.35819045
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.35255265
143negative regulation of nucleotide catabolic process (GO:0030812)2.34096055
144myeloid cell activation involved in immune response (GO:0002275)2.33826629
145regulation of tolerance induction (GO:0002643)2.33251418
146response to UV-C (GO:0010225)2.31627005
147monoubiquitinated protein deubiquitination (GO:0035520)2.30797147
148peptidyl-lysine trimethylation (GO:0018023)2.30251665
149intestinal epithelial cell development (GO:0060576)2.30056935
150mitotic G1 DNA damage checkpoint (GO:0031571)2.27682348
151leukocyte aggregation (GO:0070486)2.27474534
152regulation of Rap GTPase activity (GO:0032317)2.27307763
153negative regulation of viral release from host cell (GO:1902187)2.27003175
154megakaryocyte development (GO:0035855)2.26430582
155protein localization to chromosome, centromeric region (GO:0071459)2.25992357
156regulation of protein deacetylation (GO:0090311)2.25820651
157regulation of NFAT protein import into nucleus (GO:0051532)2.25819766
158natural killer cell differentiation (GO:0001779)2.25711715
159negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.25391053
160histone methylation (GO:0016571)2.24905999
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.23627851
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.23407023
163stress fiber assembly (GO:0043149)2.21527455
164negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.21287006
165negative regulation of histone modification (GO:0031057)2.20634281
166regulation of RNA stability (GO:0043487)2.19465749
167regulation of translational termination (GO:0006449)2.18313781
168nuclear pore complex assembly (GO:0051292)2.18172990
169histone H3 acetylation (GO:0043966)2.18099665
170regulation of mRNA stability (GO:0043488)2.17458045
171cell-substrate junction assembly (GO:0007044)2.16966691
172cell-substrate adherens junction assembly (GO:0007045)2.16811402
173focal adhesion assembly (GO:0048041)2.16811402
174protein localization to kinetochore (GO:0034501)2.16792275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.10885399
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55395100
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.33368604
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18545218
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05568553
6TCF7_22412390_ChIP-Seq_EML_Mouse3.02213789
7VDR_21846776_ChIP-Seq_THP-1_Human2.90633810
8KDM2B_26808549_Chip-Seq_DND41_Human2.83867948
9E2F7_22180533_ChIP-Seq_HELA_Human2.71862842
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70808816
11* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64436472
12* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.62538597
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61525236
14UTX_26944678_Chip-Seq_JUKART_Human2.27963660
15MAF_26560356_Chip-Seq_TH1_Human2.21335803
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11574837
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.09818627
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06923985
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.03134909
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00013168
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97054162
22KDM2B_26808549_Chip-Seq_K562_Human1.79020692
23SCL_19346495_ChIP-Seq_HPC-7_Human1.75484164
24VDR_24763502_ChIP-Seq_THP-1_Human1.73876225
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73237911
26SPI1_23127762_ChIP-Seq_K562_Human1.70626917
27RACK7_27058665_Chip-Seq_MCF-7_Human1.70428172
28LXR_22292898_ChIP-Seq_THP-1_Human1.68653553
29MYB_26560356_Chip-Seq_TH1_Human1.67880012
30MYB_26560356_Chip-Seq_TH2_Human1.64739013
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63899841
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63213718
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.62524003
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60094634
35MAF_26560356_Chip-Seq_TH2_Human1.51335593
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50405649
37RUNX_20019798_ChIP-Seq_JUKART_Human1.48520651
38ATF3_27146783_Chip-Seq_COLON_Human1.47976116
39* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46983638
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46853279
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46750991
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46316469
43* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45334089
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44689391
45* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44268046
46* RUNX1_22412390_ChIP-Seq_EML_Mouse1.43727497
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.43250002
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.42594149
49NCOR1_26117541_ChIP-Seq_K562_Human1.41656609
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39126016
51CREB1_26743006_Chip-Seq_LNCaP_Human1.36740717
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.34507736
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33947234
54CIITA_25753668_ChIP-Seq_RAJI_Human1.32691992
55* P68_20966046_ChIP-Seq_HELA_Human1.31898141
56* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30189477
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29965357
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29641260
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.29056331
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28716964
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28003248
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27796647
63* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26703675
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26373790
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25405701
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23239930
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.23065855
68* SPI1_23547873_ChIP-Seq_NB4_Human1.22229060
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21640071
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21132092
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20162765
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19348366
73GATA1_19941826_ChIP-Seq_K562_Human1.18649711
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17853647
75* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17332207
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.17105416
77GATA6_25053715_ChIP-Seq_YYC3_Human1.16893250
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16328832
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15345828
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15206440
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14180232
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13986213
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13819547
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13355626
85ZNF263_19887448_ChIP-Seq_K562_Human1.11147848
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10996694
87GATA3_27048872_Chip-Seq_THYMUS_Human1.10633654
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.08800645
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07880075
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07571714
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07080112
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07030169
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06810283
94* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06731157
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05940200
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05606240
97* SMC4_20622854_ChIP-Seq_HELA_Human1.04831924
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04024227
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03999337
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03731787
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03510071
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.03277464
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.01964253
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01447895
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01137333
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00444536
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.98550410
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98525230
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98274715
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98064179
111* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97959306
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97195538
113BCL6_27268052_Chip-Seq_Bcells_Human0.96541416
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95438706
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95226727
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94018615
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94001721
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93922865
119* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93862875
120* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93603524
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93061464
122TP53_22127205_ChIP-Seq_IMR90_Human0.92739627
123BCOR_27268052_Chip-Seq_Bcells_Human0.92552751
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.92451568
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92221584
126TP63_22573176_ChIP-Seq_HFKS_Human0.91596913
127GATA2_19941826_ChIP-Seq_K562_Human0.90850487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.38766679
2MP0003303_peritoneal_inflammation3.04365177
3MP0010234_abnormal_vibrissa_follicle2.89508628
4MP0005076_abnormal_cell_differentiation2.79772601
5MP0003724_increased_susceptibility_to2.63231832
6MP0003763_abnormal_thymus_physiology2.62335028
7MP0010352_gastrointestinal_tract_polyps2.57938669
8MP0003705_abnormal_hypodermis_morpholog2.43008577
9MP0002396_abnormal_hematopoietic_system2.40248953
10MP0009278_abnormal_bone_marrow2.38253803
11MP0008260_abnormal_autophagy2.36888449
12MP0003191_abnormal_cellular_cholesterol2.30449502
13MP0004264_abnormal_extraembryonic_tissu2.13135996
14MP0004808_abnormal_hematopoietic_stem2.10855222
15MP0004858_abnormal_nervous_system2.10352967
16MP0002419_abnormal_innate_immunity2.08578545
17MP0000685_abnormal_immune_system2.00147429
18MP0004510_myositis1.99185867
19MP0002009_preneoplasia1.94123469
20MP0005397_hematopoietic_system_phenotyp1.93596644
21MP0001545_abnormal_hematopoietic_system1.93596644
22MP0004947_skin_inflammation1.90052803
23MP0003172_abnormal_lysosome_physiology1.88279890
24MP0001849_ear_inflammation1.84080084
25MP0003693_abnormal_embryo_hatching1.82953129
26MP0003866_abnormal_defecation1.79265289
27* MP0002398_abnormal_bone_marrow1.78064027
28MP0002653_abnormal_ependyma_morphology1.73883838
29MP0005058_abnormal_lysosome_morphology1.72505155
30MP0003566_abnormal_cell_adhesion1.72283389
31MP0003183_abnormal_peptide_metabolism1.69434316
32MP0003111_abnormal_nucleus_morphology1.67813310
33MP0000703_abnormal_thymus_morphology1.66836390
34MP0005409_darkened_coat_color1.65961087
35* MP0001800_abnormal_humoral_immune1.64481361
36MP0004381_abnormal_hair_follicle1.63663978
37MP0000490_abnormal_crypts_of1.59601528
38MP0001873_stomach_inflammation1.58388294
39MP0003045_fibrosis1.55973950
40MP0010155_abnormal_intestine_physiology1.55782717
41MP0001533_abnormal_skeleton_physiology1.54463945
42MP0009785_altered_susceptibility_to1.52619475
43MP0010307_abnormal_tumor_latency1.51848767
44MP0003077_abnormal_cell_cycle1.47584879
45MP0000678_abnormal_parathyroid_gland1.47475161
46* MP0008961_abnormal_basal_metabolism1.47384533
47MP0003453_abnormal_keratinocyte_physiol1.43714595
48MP0000350_abnormal_cell_proliferation1.42976595
49MP0002166_altered_tumor_susceptibility1.41265525
50MP0001730_embryonic_growth_arrest1.39423437
51* MP0002722_abnormal_immune_system1.39236590
52* MP0002420_abnormal_adaptive_immunity1.35375644
53* MP0000716_abnormal_immune_system1.34995408
54MP0002877_abnormal_melanocyte_morpholog1.34932291
55MP0006082_CNS_inflammation1.34639582
56* MP0001819_abnormal_immune_cell1.34206009
57MP0002006_tumorigenesis1.33657203
58MP0002148_abnormal_hypersensitivity_rea1.29649041
59MP0009840_abnormal_foam_cell1.28945028
60MP0004957_abnormal_blastocyst_morpholog1.28643546
61* MP0002452_abnormal_antigen_presenting1.27182595
62* MP0000689_abnormal_spleen_morphology1.26999686
63MP0002086_abnormal_extraembryonic_tissu1.26489332
64MP0000537_abnormal_urethra_morphology1.26179510
65MP0009333_abnormal_splenocyte_physiolog1.25562993
66* MP0001790_abnormal_immune_system1.20550858
67* MP0005387_immune_system_phenotype1.20550858
68MP0003436_decreased_susceptibility_to1.20141100
69MP0003984_embryonic_growth_retardation1.19588209
70* MP0002723_abnormal_immune_serum1.19464789
71MP0002084_abnormal_developmental_patter1.19359185
72MP0005023_abnormal_wound_healing1.18527264
73* MP0002405_respiratory_system_inflammati1.18378074
74MP0002019_abnormal_tumor_incidence1.16596484
75* MP0002429_abnormal_blood_cell1.16584973
76MP0002998_abnormal_bone_remodeling1.16569071
77MP0001851_eye_inflammation1.16426728
78MP0002088_abnormal_embryonic_growth/wei1.16086550
79MP0000569_abnormal_digit_pigmentation1.16071217
80MP0001672_abnormal_embryogenesis/_devel1.16001597
81MP0005380_embryogenesis_phenotype1.16001597
82* MP0005310_abnormal_salivary_gland1.15801047
83MP0003646_muscle_fatigue1.15545289
84MP0003787_abnormal_imprinting1.14030097
85* MP0001845_abnormal_inflammatory_respons1.13462694
86MP0003075_altered_response_to1.12762233
87MP0000733_abnormal_muscle_development1.12643624
88MP0001348_abnormal_lacrimal_gland1.12324062
89MP0005451_abnormal_body_composition1.12060729
90MP0005671_abnormal_response_to1.10341776
91MP0010094_abnormal_chromosome_stability1.08985539
92MP0002796_impaired_skin_barrier1.06617598
93* MP0001697_abnormal_embryo_size1.06592529
94MP0003091_abnormal_cell_migration1.05846515
95MP0002085_abnormal_embryonic_tissue1.03522143
96MP0005464_abnormal_platelet_physiology1.03316957
97MP0005000_abnormal_immune_tolerance1.02323740
98MP0001216_abnormal_epidermal_layer1.00922635
99MP0008877_abnormal_DNA_methylation1.00769885
100MP0000858_altered_metastatic_potential0.98063482
101MP0002925_abnormal_cardiovascular_devel0.97679096
102* MP0004185_abnormal_adipocyte_glucose0.95380414
103MP0005621_abnormal_cell_physiology0.95341966
104MP0010630_abnormal_cardiac_muscle0.95332576
105MP0008469_abnormal_protein_level0.94906729
106* MP0002080_prenatal_lethality0.91839692
107MP0000465_gastrointestinal_hemorrhage0.91810824
108MP0005501_abnormal_skin_physiology0.89419453
109MP0000003_abnormal_adipose_tissue0.89394564
110MP0004859_abnormal_synaptic_plasticity0.89032131
111MP0002132_abnormal_respiratory_system0.88361835
112* MP0000477_abnormal_intestine_morphology0.87264182
113MP0002089_abnormal_postnatal_growth/wei0.85289405
114MP0000313_abnormal_cell_death0.85226695
115MP0001784_abnormal_fluid_regulation0.84825347
116MP0009931_abnormal_skin_appearance0.84790037
117MP0003329_amyloid_beta_deposits0.84522696
118MP0003448_altered_tumor_morphology0.83958681
119MP0001915_intracranial_hemorrhage0.83317249
120MP0004233_abnormal_muscle_weight0.81351166
121MP0008770_decreased_survivor_rate0.80589691
122MP0009672_abnormal_birth_weight0.79805670
123MP0005025_abnormal_response_to0.79399448
124MP0005166_decreased_susceptibility_to0.78754260
125MP0004197_abnormal_fetal_growth/weight/0.78103158
126MP0001663_abnormal_digestive_system0.77248142
127MP0002909_abnormal_adrenal_gland0.76879826
128MP0002098_abnormal_vibrissa_morphology0.75766861
129MP0001835_abnormal_antigen_presentation0.75659232
130MP0003828_pulmonary_edema0.75184256
131MP0000377_abnormal_hair_follicle0.74260229
132MP0003690_abnormal_glial_cell0.70476461
133MP0002249_abnormal_larynx_morphology0.69792626
134* MP0005666_abnormal_adipose_tissue0.69492856
135MP0005390_skeleton_phenotype0.68159640
136MP0000470_abnormal_stomach_morphology0.67391261
137MP0004883_abnormal_blood_vessel0.66988896
138MP0003879_abnormal_hair_cell0.63506156

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.77096067
2Recurrent bacterial skin infections (HP:0005406)3.59670214
3Recurrent abscess formation (HP:0002722)3.59600719
4Abnormality of macrophages (HP:0004311)3.44569195
5Hyperacusis (HP:0010780)3.15201198
6Myositis (HP:0100614)3.12498949
7Broad face (HP:0000283)3.10940575
8Flat acetabular roof (HP:0003180)2.99649427
9Orchitis (HP:0100796)2.95526687
10Gingivitis (HP:0000230)2.77013643
11Recurrent gram-negative bacterial infections (HP:0005420)2.65640260
12Cerebral aneurysm (HP:0004944)2.64096800
13Obstructive lung disease (HP:0006536)2.62966033
14Chronic obstructive pulmonary disease (HP:0006510)2.62966033
15Nasal polyposis (HP:0100582)2.61597574
16Gastrointestinal infarctions (HP:0005244)2.56210062
17Autoimmune thrombocytopenia (HP:0001973)2.53977912
18Mediastinal lymphadenopathy (HP:0100721)2.52525383
19Increased IgE level (HP:0003212)2.48843236
20Long eyelashes (HP:0000527)2.47776203
21Retrobulbar optic neuritis (HP:0100654)2.46802149
22Optic neuritis (HP:0100653)2.46802149
23Heterotopia (HP:0002282)2.44968773
24Pustule (HP:0200039)2.43794935
25Urethral obstruction (HP:0000796)2.43300539
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.39870153
27Meningitis (HP:0001287)2.39863878
28Prominent nose (HP:0000448)2.38108177
29Segmental peripheral demyelination/remyelination (HP:0003481)2.37885981
30Male infertility (HP:0003251)2.37516254
31Abnormality of the nasal mucosa (HP:0000433)2.34990844
32Recurrent viral infections (HP:0004429)2.32809091
33Recurrent fungal infections (HP:0002841)2.29297308
34Milia (HP:0001056)2.29202620
35Spontaneous hematomas (HP:0007420)2.27706793
36Urticaria (HP:0001025)2.23026986
37Colitis (HP:0002583)2.22070269
38Recurrent skin infections (HP:0001581)2.21385911
39Elevated erythrocyte sedimentation rate (HP:0003565)2.20568044
40Lip pit (HP:0100267)2.20446656
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19452557
42Volvulus (HP:0002580)2.18785544
43Dysmetric saccades (HP:0000641)2.18642431
44Gastrointestinal inflammation (HP:0004386)2.18214918
45Slow saccadic eye movements (HP:0000514)2.15999421
46Broad palm (HP:0001169)2.14150163
47Cellulitis (HP:0100658)2.13923821
48Deep palmar crease (HP:0006191)2.13723348
49Thin bony cortex (HP:0002753)2.13456655
50Annular pancreas (HP:0001734)2.09255435
51Inflammation of the large intestine (HP:0002037)2.09250594
52Macroorchidism (HP:0000053)2.06114174
53Metaphyseal cupping (HP:0003021)2.05839520
54Increased cerebral lipofuscin (HP:0011813)2.05614086
55Hemorrhage of the eye (HP:0011885)2.05152431
56Sparse lateral eyebrow (HP:0005338)2.04695342
57Vasculitis (HP:0002633)2.04390323
58Genu recurvatum (HP:0002816)2.03605181
59Fatigue (HP:0012378)2.00918019
60Basal cell carcinoma (HP:0002671)2.00397990
61Sandal gap (HP:0001852)1.99893351
62Pointed chin (HP:0000307)1.98964261
63Ureteral stenosis (HP:0000071)1.98144830
64Prolonged bleeding time (HP:0003010)1.97211088
65T lymphocytopenia (HP:0005403)1.96182124
66Acute myeloid leukemia (HP:0004808)1.96179613
67Verrucae (HP:0200043)1.96144473
68Papilloma (HP:0012740)1.96144473
69Shawl scrotum (HP:0000049)1.94508662
70Increased nuchal translucency (HP:0010880)1.94200336
71Chronic otitis media (HP:0000389)1.93399065
72Acute lymphatic leukemia (HP:0006721)1.93323948
73Panhypogammaglobulinemia (HP:0003139)1.92417083
74Abnormality of the distal phalanges of the toes (HP:0010182)1.92319036
75Narrow palate (HP:0000189)1.92206389
76Malnutrition (HP:0004395)1.91061253
77Axonal loss (HP:0003447)1.90323304
78Loss of speech (HP:0002371)1.90172172
79Keratoconjunctivitis sicca (HP:0001097)1.89942666
80Polycythemia (HP:0001901)1.89852425
81Trigonocephaly (HP:0000243)1.88637919
82Aortic aneurysm (HP:0004942)1.88178618
83Abnormal vertebral ossification (HP:0100569)1.87887212
84Aneurysm (HP:0002617)1.87485769
85Increased connective tissue (HP:0009025)1.87298070
86Elfin facies (HP:0004428)1.87129806
87Obstructive sleep apnea (HP:0002870)1.86959072
88Hypochromic anemia (HP:0001931)1.86529287
89Arterial thrombosis (HP:0004420)1.84691260
90Polygenic inheritance (HP:0010982)1.84188901
91Osteomyelitis (HP:0002754)1.82235062
92Ureteral obstruction (HP:0006000)1.81859402
93Stomatitis (HP:0010280)1.81090821
94Subacute progressive viral hepatitis (HP:0006572)1.80059911
95Interstitial pulmonary disease (HP:0006530)1.79809387
96Rectal prolapse (HP:0002035)1.79528137
97Germ cell neoplasia (HP:0100728)1.79330465
98Recurrent bronchitis (HP:0002837)1.79153841
99Encephalitis (HP:0002383)1.78043794
100Cerebral inclusion bodies (HP:0100314)1.77538297
101Distal upper limb amyotrophy (HP:0007149)1.76809306
102Upper limb amyotrophy (HP:0009129)1.76809306
103Short phalanx of the thumb (HP:0009660)1.75940290
104Truncal obesity (HP:0001956)1.75642526
105Ependymoma (HP:0002888)1.75515737
106Amyloidosis (HP:0011034)1.75489550
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.75389423
108Disproportionate tall stature (HP:0001519)1.75046181
109Distal lower limb amyotrophy (HP:0008944)1.73535725
110Insomnia (HP:0100785)1.73331516
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.73246169
112Abnormality of the gastric mucosa (HP:0004295)1.72803604
113Abnormality of T cell number (HP:0011839)1.72228018
114Right ventricular cardiomyopathy (HP:0011663)1.71899102
115Increased density of long bones (HP:0006392)1.71845174
116Vertebral arch anomaly (HP:0008438)1.70965587
117Growth hormone excess (HP:0000845)1.70585412
118Ulnar bowing (HP:0003031)1.70070002
119Abnormality of the phalanges of the hallux (HP:0010057)1.69917862
120Facial hemangioma (HP:0000329)1.69289211
121Neuronal loss in central nervous system (HP:0002529)1.68793329
122Recurrent cutaneous fungal infections (HP:0011370)1.68754991
123Chronic mucocutaneous candidiasis (HP:0002728)1.68754991
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.68570902
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68445280
126Gastrointestinal stroma tumor (HP:0100723)1.68344950
127Abnormality of T cells (HP:0002843)1.68152417
128Onion bulb formation (HP:0003383)1.67862845
129Neoplasm of the heart (HP:0100544)1.67829719
130Skin ulcer (HP:0200042)1.67677042
131Blepharitis (HP:0000498)1.67318494
132Overlapping toe (HP:0001845)1.67292011
133Hyperparathyroidism (HP:0000843)1.66639766
134Proximal placement of thumb (HP:0009623)1.66059343
135Abnormality of oral frenula (HP:0000190)1.65907754
136Hypercortisolism (HP:0001578)1.65738638
137Bundle branch block (HP:0011710)1.65706162
138Deviation of the thumb (HP:0009603)1.65586060
139Malignant gastrointestinal tract tumors (HP:0006749)1.65546431
140Gastrointestinal carcinoma (HP:0002672)1.65546431
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65116020
142Short 4th metacarpal (HP:0010044)1.65116020
143Long palpebral fissure (HP:0000637)1.64719450
144Hand muscle atrophy (HP:0009130)1.64274281
145Dysostosis multiplex (HP:0000943)1.64150167
146IgM deficiency (HP:0002850)1.63661039
147Sepsis (HP:0100806)1.63150399
148Ankyloglossia (HP:0010296)1.62876375
149Eczematoid dermatitis (HP:0000976)1.62335417
150Genetic anticipation (HP:0003743)1.61550047
151Mitral valve prolapse (HP:0001634)1.61457822
152Villous atrophy (HP:0011473)1.61007621
153Abnormality of small intestinal villus morphology (HP:0011472)1.61007621
154Ankle clonus (HP:0011448)1.60784974
155Distal lower limb muscle weakness (HP:0009053)1.60641278
156Chest pain (HP:0100749)1.60585187
157Agammaglobulinemia (HP:0004432)1.60357482
158Neonatal hypoglycemia (HP:0001998)1.60225668
159Keratoconjunctivitis (HP:0001096)1.60090745
160Abnormality of the thoracic spine (HP:0100711)1.59532070
161Combined immunodeficiency (HP:0005387)1.59470838
162Achilles tendon contracture (HP:0001771)1.58967388
163Shallow orbits (HP:0000586)1.58798936
164Micronodular cirrhosis (HP:0001413)1.58333974
165Neoplasm of the oral cavity (HP:0100649)1.58321596
166Broad thumb (HP:0011304)1.58212686
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58193728
168Epistaxis (HP:0000421)1.57120207
169Testicular neoplasm (HP:0010788)1.57017784
170Pili torti (HP:0003777)1.56881974
171Severe short stature (HP:0003510)1.56506277
172Episodic fever (HP:0001954)1.56402009
173Spondylolisthesis (HP:0003302)1.56089057
174Persistence of primary teeth (HP:0006335)1.55412032
175Cervical subluxation (HP:0003308)1.53572176
176Viral hepatitis (HP:0006562)1.53471458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.05249611
2TRIB33.87786643
3CDK123.46354277
4MAP4K13.09068190
5PRPF4B2.98071102
6SMG12.90695020
7MAP3K102.64622428
8LATS12.55989123
9TAOK32.50706487
10PKN22.47255979
11TNK22.39716646
12MAP3K92.30767944
13DMPK2.22107247
14STK102.17447753
15KSR22.10975109
16IRAK42.05476280
17IRAK32.05401585
18ERN12.05258306
19RIPK11.91234404
20MAP2K31.88627977
21LATS21.66731436
22NEK21.57457690
23GRK61.56426761
24MAP3K31.53223926
25TYRO31.51827831
26PRKD31.50983952
27BLK1.43641868
28JAK31.41413701
29MAP3K131.39008117
30MAP3K61.36491658
31ICK1.31745336
32IRAK21.30530527
33CAMK1G1.30369187
34STK381.30293720
35ALK1.30058968
36EPHA21.26682276
37MAPKAPK31.24425822
38SIK21.23235637
39MAP3K71.18960007
40RAF11.18522910
41CAMK1D1.15602500
42LRRK21.14963690
43MTOR1.11675960
44ZAP701.11581753
45STK31.08155751
46SIK31.07900754
47MAP3K141.05768351
48CDK91.03465781
49TAOK21.00229485
50PTK60.98459730
51HIPK20.96880125
52CDK40.95409177
53PAK60.94336543
54PRKCH0.92411268
55TYK20.91628381
56CDC70.90699425
57ARAF0.90150505
58EPHB10.89049662
59TTN0.87494364
60RET0.85864473
61FGR0.84343231
62FGFR30.84333529
63HCK0.83966225
64PDGFRA0.82917955
65ITK0.81458491
66PDGFRB0.81372094
67CDK60.81178539
68JAK10.79265616
69MAP3K80.78688814
70BMX0.74577898
71JAK20.74380378
72IRAK10.73629745
73RPS6KA20.73028555
74CSK0.72701225
75MAP3K10.71983773
76PDK10.71186483
77RPS6KA40.70078057
78IKBKE0.69815005
79PTK20.69765939
80SGK30.69240198
81TTK0.66497840
82CSF1R0.66305695
83YES10.65248737
84MAP2K20.65176807
85MELK0.64656483
86RPS6KC10.63961121
87RPS6KL10.63961121
88MAPK110.63042310
89RPS6KB20.62137682
90* PRKD20.61543089
91SIK10.59302522
92FGFR40.58959806
93PIM10.55979775
94PAK40.55620247
95BTK0.55477287
96MATK0.55142289
97PRKG20.54844705
98* MARK20.54577388
99MST1R0.54348882
100MAP3K110.51500073
101PDPK10.51355817
102CHUK0.50741073
103CAMKK10.50358760
104CHEK10.49255514
105TBK10.48969626
106BRAF0.48556056
107PIM20.47037384
108CDC42BPA0.46722208
109FES0.46419742
110RPS6KA60.45598952
111NLK0.44832570
112LYN0.43697480
113PRKAA10.43571182
114CHEK20.43336011
115MARK30.42413640
116SCYL20.42169298
117RPS6KA10.41927298
118PRKAA20.41482468
119TESK10.41458009
120CDK70.41093940
121MAPK120.41056279
122MOS0.40792540
123SYK0.40587434
124TXK0.40314538
125CDK20.40183818
126BRD40.40010436
127TESK20.38694419
128MAP3K20.38649668
129FER0.38641786
130DYRK1B0.38543113
131RIPK40.38211487
132LCK0.38011199
133MAPKAPK20.37851948
134WNK10.37806874
135MAPK70.36998596
136KSR10.36170529
137LMTK20.36150359

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09180115
2Chronic myeloid leukemia_Homo sapiens_hsa052201.84582011
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72417506
4B cell receptor signaling pathway_Homo sapiens_hsa046621.71344900
5Pancreatic cancer_Homo sapiens_hsa052121.64595876
6Other glycan degradation_Homo sapiens_hsa005111.62632322
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62008289
8VEGF signaling pathway_Homo sapiens_hsa043701.61584916
9Primary immunodeficiency_Homo sapiens_hsa053401.55639301
10mTOR signaling pathway_Homo sapiens_hsa041501.55632586
11T cell receptor signaling pathway_Homo sapiens_hsa046601.51363066
12Acute myeloid leukemia_Homo sapiens_hsa052211.50574285
13Non-small cell lung cancer_Homo sapiens_hsa052231.48129859
14Fatty acid biosynthesis_Homo sapiens_hsa000611.43553163
15Dorso-ventral axis formation_Homo sapiens_hsa043201.39663348
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.39040889
17Endometrial cancer_Homo sapiens_hsa052131.37860626
18Hepatitis C_Homo sapiens_hsa051601.36454579
19Osteoclast differentiation_Homo sapiens_hsa043801.31612853
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.30805611
21Colorectal cancer_Homo sapiens_hsa052101.28254106
22Prolactin signaling pathway_Homo sapiens_hsa049171.26686694
23Notch signaling pathway_Homo sapiens_hsa043301.26002777
24Glioma_Homo sapiens_hsa052141.24687304
25Adherens junction_Homo sapiens_hsa045201.21502521
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20350663
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17020370
28Thyroid cancer_Homo sapiens_hsa052161.15917933
29Staphylococcus aureus infection_Homo sapiens_hsa051501.15426426
30Renal cell carcinoma_Homo sapiens_hsa052111.15384039
31MicroRNAs in cancer_Homo sapiens_hsa052061.13853168
32Lysine degradation_Homo sapiens_hsa003101.12968213
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12120233
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11771254
35Leishmaniasis_Homo sapiens_hsa051401.09903961
36Platelet activation_Homo sapiens_hsa046111.09656275
37Choline metabolism in cancer_Homo sapiens_hsa052311.09508402
38Small cell lung cancer_Homo sapiens_hsa052221.09128932
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08899898
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.08423720
41Toxoplasmosis_Homo sapiens_hsa051451.07700457
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07178303
43Hepatitis B_Homo sapiens_hsa051611.06920356
44Estrogen signaling pathway_Homo sapiens_hsa049151.06187794
45Chemokine signaling pathway_Homo sapiens_hsa040621.05961699
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05592990
47GnRH signaling pathway_Homo sapiens_hsa049121.05371918
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03181731
49Type II diabetes mellitus_Homo sapiens_hsa049301.01834639
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00776578
51Shigellosis_Homo sapiens_hsa051310.97400952
52ErbB signaling pathway_Homo sapiens_hsa040120.96874316
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.96007794
54Malaria_Homo sapiens_hsa051440.93729458
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.93690951
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93022275
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93010200
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92480084
59HTLV-I infection_Homo sapiens_hsa051660.92298297
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.91009422
61Insulin resistance_Homo sapiens_hsa049310.90400547
62Cell cycle_Homo sapiens_hsa041100.90303573
63Bladder cancer_Homo sapiens_hsa052190.90177343
64Long-term potentiation_Homo sapiens_hsa047200.90106374
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89158477
66Proteoglycans in cancer_Homo sapiens_hsa052050.88582417
67Measles_Homo sapiens_hsa051620.86972695
68Herpes simplex infection_Homo sapiens_hsa051680.86445289
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85852686
70Endocytosis_Homo sapiens_hsa041440.85806521
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85707554
72Amoebiasis_Homo sapiens_hsa051460.84874911
73FoxO signaling pathway_Homo sapiens_hsa040680.84805228
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84630190
75Viral myocarditis_Homo sapiens_hsa054160.84337516
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84235627
77Graft-versus-host disease_Homo sapiens_hsa053320.83707600
78TNF signaling pathway_Homo sapiens_hsa046680.83451153
79MAPK signaling pathway_Homo sapiens_hsa040100.83388994
80Antigen processing and presentation_Homo sapiens_hsa046120.83053623
81Inositol phosphate metabolism_Homo sapiens_hsa005620.80412625
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.80227839
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80206506
84Oocyte meiosis_Homo sapiens_hsa041140.79995078
85Influenza A_Homo sapiens_hsa051640.78626828
86Insulin signaling pathway_Homo sapiens_hsa049100.78106567
87Gastric acid secretion_Homo sapiens_hsa049710.77259717
88Rap1 signaling pathway_Homo sapiens_hsa040150.77141737
89Apoptosis_Homo sapiens_hsa042100.76423584
90Focal adhesion_Homo sapiens_hsa045100.75389281
91Allograft rejection_Homo sapiens_hsa053300.75280042
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.74852703
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.73210874
94p53 signaling pathway_Homo sapiens_hsa041150.71993727
95mRNA surveillance pathway_Homo sapiens_hsa030150.71748836
96HIF-1 signaling pathway_Homo sapiens_hsa040660.71711017
97Legionellosis_Homo sapiens_hsa051340.71603958
98Oxytocin signaling pathway_Homo sapiens_hsa049210.71443037
99Prostate cancer_Homo sapiens_hsa052150.71342762
100Autoimmune thyroid disease_Homo sapiens_hsa053200.70298097
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69566917
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69080055
103African trypanosomiasis_Homo sapiens_hsa051430.68980176
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68407249
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68222834
106AMPK signaling pathway_Homo sapiens_hsa041520.68076429
107Lysosome_Homo sapiens_hsa041420.67835960
108Circadian rhythm_Homo sapiens_hsa047100.67217999
109Prion diseases_Homo sapiens_hsa050200.66209781
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65852754
111Hippo signaling pathway_Homo sapiens_hsa043900.65125461
112Viral carcinogenesis_Homo sapiens_hsa052030.64872978
113Tuberculosis_Homo sapiens_hsa051520.64507507
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64172029
115Pathways in cancer_Homo sapiens_hsa052000.63122603
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62896985
117Hematopoietic cell lineage_Homo sapiens_hsa046400.61598271
118Salmonella infection_Homo sapiens_hsa051320.61144624
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61049401
120Phagosome_Homo sapiens_hsa041450.58967730
121Renin-angiotensin system_Homo sapiens_hsa046140.58062773
122Pertussis_Homo sapiens_hsa051330.57884056

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