MARCH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.46363838
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08627610
3cell migration in hindbrain (GO:0021535)5.07003717
4neuron cell-cell adhesion (GO:0007158)4.90536548
5locomotory exploration behavior (GO:0035641)4.68395293
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.65467088
7synaptic vesicle maturation (GO:0016188)4.49711237
8dendritic spine morphogenesis (GO:0060997)4.44301249
9vocalization behavior (GO:0071625)4.36460834
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35114062
11pyrimidine nucleobase catabolic process (GO:0006208)4.33919370
12synaptic vesicle exocytosis (GO:0016079)4.23186797
13protein localization to synapse (GO:0035418)4.23080538
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03820678
15exploration behavior (GO:0035640)4.03516685
16neuron recognition (GO:0008038)3.84181808
17dendrite morphogenesis (GO:0048813)3.77185790
18regulation of glutamate receptor signaling pathway (GO:1900449)3.74315270
19postsynaptic membrane organization (GO:0001941)3.70260821
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.67200702
21negative regulation of cell killing (GO:0031342)3.64438732
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64438732
23regulation of synaptic vesicle exocytosis (GO:2000300)3.63871765
24axonal fasciculation (GO:0007413)3.61979449
25negative regulation of microtubule polymerization (GO:0031115)3.58654884
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.58101551
27mitochondrion transport along microtubule (GO:0047497)3.58101551
28central nervous system projection neuron axonogenesis (GO:0021952)3.54565543
29glutamate secretion (GO:0014047)3.52525208
30positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.46525236
31NIK/NF-kappaB signaling (GO:0038061)3.45275792
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.45083952
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43260814
34negative regulation of cell cycle arrest (GO:0071157)3.42106907
35regulation of synapse structural plasticity (GO:0051823)3.41807736
36positive regulation of histone deacetylation (GO:0031065)3.36945379
37proline transport (GO:0015824)3.34654696
38nucleobase catabolic process (GO:0046113)3.34523473
39positive regulation of synapse maturation (GO:0090129)3.34344133
40establishment of mitochondrion localization (GO:0051654)3.30585559
41regulation of interferon-gamma biosynthetic process (GO:0045072)3.22414670
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22022702
43positive regulation of lymphocyte apoptotic process (GO:0070230)3.21501616
44neurotransmitter secretion (GO:0007269)3.18415129
45negative regulation of cAMP-mediated signaling (GO:0043951)3.16782283
46cerebellar Purkinje cell layer development (GO:0021680)3.16466578
47mating behavior (GO:0007617)3.15150225
48innervation (GO:0060384)3.14127026
49interferon-gamma production (GO:0032609)3.13415121
50behavioral response to nicotine (GO:0035095)3.11527048
51regulation of neuronal synaptic plasticity (GO:0048168)3.10403889
52neuromuscular process controlling balance (GO:0050885)3.10230865
53adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07693772
54synaptic vesicle endocytosis (GO:0048488)3.07258089
55positive regulation of CREB transcription factor activity (GO:0032793)3.06631727
56positive regulation of dendritic spine development (GO:0060999)3.06223816
57activation of protein kinase A activity (GO:0034199)3.05839281
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05775381
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.04701699
60axon extension (GO:0048675)3.03609242
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02989723
62histone H3-K4 trimethylation (GO:0080182)3.02072950
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.01783600
64positive thymic T cell selection (GO:0045059)2.98855487
65regulation of dendritic spine morphogenesis (GO:0061001)2.98562275
66regulation of cAMP-dependent protein kinase activity (GO:2000479)2.98099768
67regulation of synaptic vesicle transport (GO:1902803)2.96040100
68thymic T cell selection (GO:0045061)2.95494644
69protein retention in ER lumen (GO:0006621)2.94218126
70positive T cell selection (GO:0043368)2.93545588
71synapse assembly (GO:0007416)2.92111239
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92109244
73positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91076092
74negative regulation of Ras GTPase activity (GO:0034261)2.85851798
75dopamine receptor signaling pathway (GO:0007212)2.82409011
76glutamate receptor signaling pathway (GO:0007215)2.81883211
77positive regulation of membrane potential (GO:0045838)2.81620764
78cerebellum development (GO:0021549)2.81554427
79defense response to protozoan (GO:0042832)2.81265516
80social behavior (GO:0035176)2.80527556
81intraspecies interaction between organisms (GO:0051703)2.80527556
82synaptic transmission, glutamatergic (GO:0035249)2.79770070
83central nervous system neuron axonogenesis (GO:0021955)2.79557987
84T cell selection (GO:0045058)2.78342512
85ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.77131896
86positive regulation of T cell apoptotic process (GO:0070234)2.76971665
87dendritic spine organization (GO:0097061)2.74743802
88opioid receptor signaling pathway (GO:0038003)2.74344974
89auditory behavior (GO:0031223)2.73750311
90regulation of glycogen (starch) synthase activity (GO:2000465)2.72897919
91protein insertion into membrane (GO:0051205)2.72891083
92positive regulation of synapse assembly (GO:0051965)2.72622586
93regulation of respiratory system process (GO:0044065)2.72442280
94activated T cell proliferation (GO:0050798)2.72397078
95negative regulation of catenin import into nucleus (GO:0035414)2.71950716
96regulation of histone deacetylation (GO:0031063)2.71937723
97positive regulation of defense response to virus by host (GO:0002230)2.68536443
98presynaptic membrane assembly (GO:0097105)2.67635267
99neuron projection extension (GO:1990138)2.67120918
100clathrin coat assembly (GO:0048268)2.67067108
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66780027
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66538733
103hippocampus development (GO:0021766)2.66137721
104response to type I interferon (GO:0034340)2.65317262
105synapse organization (GO:0050808)2.65274085
106response to protozoan (GO:0001562)2.65109493
107cerebral cortex neuron differentiation (GO:0021895)2.63400174
108cell-cell junction maintenance (GO:0045217)2.63105338
109type I interferon signaling pathway (GO:0060337)2.61174948
110cellular response to type I interferon (GO:0071357)2.61174948
111positive regulation of protein homooligomerization (GO:0032464)2.60334536
112startle response (GO:0001964)2.60287970
113tolerance induction (GO:0002507)2.60140363
114regulation of interleukin-2 biosynthetic process (GO:0045076)2.59988233
115neuronal ion channel clustering (GO:0045161)2.58948872
116transmission of nerve impulse (GO:0019226)2.58802210
117positive regulation of gamma-delta T cell activation (GO:0046645)2.58782527
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.58643437
119regulation of postsynaptic membrane potential (GO:0060078)2.58030677
120neurotransmitter-gated ion channel clustering (GO:0072578)2.57906196
121regulation of dendritic spine development (GO:0060998)2.57271206
122organelle transport along microtubule (GO:0072384)2.57073423
123synaptic transmission, cholinergic (GO:0007271)2.56770804
124positive regulation of calcium-mediated signaling (GO:0050850)2.56735728
125interferon-gamma secretion (GO:0072643)2.56687307
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56498828
127response to pheromone (GO:0019236)2.56494129
128regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55825723
129regulation of vesicle fusion (GO:0031338)2.55801892
130gamma-aminobutyric acid transport (GO:0015812)2.55563949
131establishment of monopolar cell polarity (GO:0061162)2.55512958
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.55512958
133neuron-neuron synaptic transmission (GO:0007270)2.55089124
134regulation of axon extension (GO:0030516)2.54653937
135axon cargo transport (GO:0008088)2.54308022
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54223587
137positive regulation of filopodium assembly (GO:0051491)2.53956844
138antigen processing and presentation of endogenous antigen (GO:0019883)2.53856305
139prepulse inhibition (GO:0060134)2.52735337
140fear response (GO:0042596)2.52707220
141regulation of autophagic vacuole assembly (GO:2000785)2.52369762
142long-term memory (GO:0007616)2.51761730
143regulation of interferon-beta biosynthetic process (GO:0045357)2.50783761
144cellular response to ATP (GO:0071318)2.50623147
145peptidyl-arginine omega-N-methylation (GO:0035247)2.49860145
146regulation of microtubule polymerization (GO:0031113)2.49736664
147behavioral fear response (GO:0001662)2.48613220
148behavioral defense response (GO:0002209)2.48613220
149diaphragm development (GO:0060539)2.48548225
150positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.44473308
151regulation of cAMP-mediated signaling (GO:0043949)2.42597388
152positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41912522
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.40149702
154negative regulation of calcium ion transport into cytosol (GO:0010523)2.39604915
155positive regulation of protein deacetylation (GO:0090312)2.36992004
156negative regulation of cytokine biosynthetic process (GO:0042036)2.36768164
157skeletal muscle organ development (GO:0060538)2.35708217
158ganglioside metabolic process (GO:0001573)2.33677974
159hypothalamus development (GO:0021854)2.33540209
160modulation by virus of host process (GO:0019054)2.33369227
161histone H3-K9 modification (GO:0061647)2.33344914
162viral protein processing (GO:0019082)2.29724761
163regulation of apoptotic process involved in morphogenesis (GO:1902337)2.28920577
164substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.28104801
165substrate-independent telencephalic tangential migration (GO:0021826)2.28104801
166RNA destabilization (GO:0050779)2.27013087
167genetic imprinting (GO:0071514)2.26128740
168regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.24767049
169macrophage activation involved in immune response (GO:0002281)2.24600919
170regulation of chemokine biosynthetic process (GO:0045073)2.22405839
171T cell lineage commitment (GO:0002360)2.20457342
172negative regulation of protein oligomerization (GO:0032460)2.19699291
173glycosphingolipid biosynthetic process (GO:0006688)2.19237290
174histone H3-K9 methylation (GO:0051567)2.18607443
175activation of MAPKKK activity (GO:0000185)2.17437046
176T cell migration (GO:0072678)2.16573156
177positive regulation of leukocyte apoptotic process (GO:2000108)2.16508701
178negative regulation of T cell mediated immunity (GO:0002710)2.16181183
179hydrogen peroxide biosynthetic process (GO:0050665)2.15727127
180modulation by symbiont of host cellular process (GO:0044068)2.14988583
181myeloid dendritic cell differentiation (GO:0043011)2.13420269
182regulation of protein homooligomerization (GO:0032462)2.13381706
183regulation of vacuole organization (GO:0044088)2.12998039
184regulation of defense response to virus by host (GO:0050691)2.12663679
185N-acetylneuraminate metabolic process (GO:0006054)2.12103554
186regulation of T cell tolerance induction (GO:0002664)2.11468501
187positive regulation of triglyceride biosynthetic process (GO:0010867)2.09216993
188regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.09079715
189regulation of natural killer cell mediated immunity (GO:0002715)2.09079715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08954938
2JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92312115
3VDR_21846776_ChIP-Seq_THP-1_Human2.82787299
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.81804293
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.79716924
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.78394715
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75906242
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65963064
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65491952
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65491952
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61177512
12REST_21632747_ChIP-Seq_MESCs_Mouse2.53952443
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43742192
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43068597
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.38800969
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34017058
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.32870035
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.31832729
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28737024
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.26202338
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25479450
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.24335807
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.21602117
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20895230
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20011502
26MYC_22102868_ChIP-Seq_BL_Human2.16901183
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15557973
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14378225
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11713320
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.05169406
31P68_20966046_ChIP-Seq_HELA_Human2.04347045
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02363273
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02309890
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97599781
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.92412202
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.92049955
37MAF_26560356_Chip-Seq_TH2_Human1.90482416
38DROSHA_22980978_ChIP-Seq_HELA_Human1.90255980
39KDM2B_26808549_Chip-Seq_K562_Human1.88106507
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.85133323
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.83915831
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83897191
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79271271
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77524472
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.76172451
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75089685
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.74286719
48BCL6_27268052_Chip-Seq_Bcells_Human1.73495172
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73262336
50RACK7_27058665_Chip-Seq_MCF-7_Human1.72216754
51GBX2_23144817_ChIP-Seq_PC3_Human1.68608557
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64209726
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61020376
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59098730
55ZNF274_21170338_ChIP-Seq_K562_Hela1.59021117
56MAF_26560356_Chip-Seq_TH1_Human1.56463304
57BCOR_27268052_Chip-Seq_Bcells_Human1.56117781
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.55833567
59TCF7_22412390_ChIP-Seq_EML_Mouse1.55533134
60VDR_24763502_ChIP-Seq_THP-1_Human1.50196360
61E2F1_20622854_ChIP-Seq_HELA_Human1.50036327
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50026209
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48605503
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46367199
65AR_21572438_ChIP-Seq_LNCaP_Human1.44164517
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43910691
67UTX_26944678_Chip-Seq_JUKART_Human1.43785775
68SA1_27219007_Chip-Seq_Bcells_Human1.43006998
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42662010
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.42636167
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42523103
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41949920
73LXR_22292898_ChIP-Seq_THP-1_Human1.41693978
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41368715
75ZNF263_19887448_ChIP-Seq_K562_Human1.40637934
76PHF8_20622854_ChIP-Seq_HELA_Human1.40591852
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40030443
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39672499
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39603032
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39438832
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39351919
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37962773
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37727609
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.37684735
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36661171
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35951137
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35769353
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35032076
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33652876
90CTCF_27219007_Chip-Seq_Bcells_Human1.33001887
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32176000
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30623352
93CIITA_25753668_ChIP-Seq_RAJI_Human1.29170274
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.28869036
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28425883
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27525069
97RNF2_27304074_Chip-Seq_NSC_Mouse1.24236699
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23979543
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.22817224
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.22319627
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19953968
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18320105
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16570664
104CTCF_20526341_ChIP-Seq_ESCs_Human1.16044101
105KDM2B_26808549_Chip-Seq_DND41_Human1.15785907
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15779858
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15395718
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14419686
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12771329
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11779266
111TP53_22127205_ChIP-Seq_IMR90_Human1.10407549
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09704649
113CREB1_26743006_Chip-Seq_LNCaP_Human1.08330581
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.07913764
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.06993684
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06558962
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06259427
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.05187053
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.03918482
120ERA_21632823_ChIP-Seq_H3396_Human1.03617925
121TP63_22573176_ChIP-Seq_HFKS_Human1.02916493
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02117820
123AR_19668381_ChIP-Seq_PC3_Human0.99896069
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99610597
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.99129099
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98002679
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97605820
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97086467
129POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96414353
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96178387
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.91588125
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91040144
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90765102
134AHR_22903824_ChIP-Seq_MCF-7_Human0.89648306
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.89042592
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88563427
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.87762383
138OCT4_19829295_ChIP-Seq_ESCs_Human0.87430406
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.86203155
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85981688
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85193529
142SOX3_22085726_ChIP-Seq_NPCs_Mouse0.84962745
143SMC4_20622854_ChIP-Seq_HELA_Human0.84613659
144CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83402742
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81704129
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81327128
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80933849
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80540675
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80540675
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80540675
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.80124054
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79650510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.46810959
2MP0004270_analgesia3.27110772
3MP0003635_abnormal_synaptic_transmissio3.13787228
4MP0003880_abnormal_central_pattern3.10223475
5MP0003303_peritoneal_inflammation2.83769682
6MP0002063_abnormal_learning/memory/cond2.61848965
7MP0005423_abnormal_somatic_nervous2.60026603
8MP0000778_abnormal_nervous_system2.53273424
9MP0003123_paternal_imprinting2.32445781
10MP0002909_abnormal_adrenal_gland2.30684676
11MP0003283_abnormal_digestive_organ2.29829396
12MP0002184_abnormal_innervation2.25259942
13MP0002734_abnormal_mechanical_nocicepti2.21863856
14MP0004381_abnormal_hair_follicle2.20164031
15MP0002572_abnormal_emotion/affect_behav2.17199176
16MP0003172_abnormal_lysosome_physiology2.15808074
17MP0009745_abnormal_behavioral_response2.11540197
18MP0002733_abnormal_thermal_nociception2.10797243
19MP0002163_abnormal_gland_morphology2.05584176
20MP0003436_decreased_susceptibility_to2.03956500
21MP0002064_seizures2.02169720
22MP0004858_abnormal_nervous_system1.96510864
23MP0000955_abnormal_spinal_cord1.92818582
24MP0001968_abnormal_touch/_nociception1.92763688
25MP0001986_abnormal_taste_sensitivity1.92672694
26MP0001790_abnormal_immune_system1.92087598
27MP0005387_immune_system_phenotype1.92087598
28MP0005075_abnormal_melanosome_morpholog1.90114511
29MP0005379_endocrine/exocrine_gland_phen1.89626512
30MP0005671_abnormal_response_to1.89404809
31MP0002653_abnormal_ependyma_morphology1.88056627
32MP0001873_stomach_inflammation1.82843103
33MP0006276_abnormal_autonomic_nervous1.80301316
34MP0005058_abnormal_lysosome_morphology1.78890457
35MP0001970_abnormal_pain_threshold1.76877495
36MP0005310_abnormal_salivary_gland1.76654638
37MP0004811_abnormal_neuron_physiology1.74917027
38MP0002735_abnormal_chemical_nociception1.72765318
39MP0009046_muscle_twitch1.72328130
40MP0005000_abnormal_immune_tolerance1.71052416
41MP0002557_abnormal_social/conspecific_i1.69084027
42MP0004885_abnormal_endolymph1.68650372
43MP0001800_abnormal_humoral_immune1.67767475
44MP0006072_abnormal_retinal_apoptosis1.62950053
45MP0002272_abnormal_nervous_system1.61907059
46MP0001486_abnormal_startle_reflex1.61458305
47MP0001440_abnormal_grooming_behavior1.59934006
48MP0005394_taste/olfaction_phenotype1.59074537
49MP0005499_abnormal_olfactory_system1.59074537
50MP0002882_abnormal_neuron_morphology1.58276877
51MP0004510_myositis1.57708320
52MP0003119_abnormal_digestive_system1.56389471
53MP0000685_abnormal_immune_system1.56102733
54MP0009780_abnormal_chondrocyte_physiolo1.52705122
55MP0003122_maternal_imprinting1.47562635
56MP0002067_abnormal_sensory_capabilities1.46330846
57MP0003763_abnormal_thymus_physiology1.45141862
58MP0000631_abnormal_neuroendocrine_gland1.44775169
59MP0004233_abnormal_muscle_weight1.42977288
60MP0005645_abnormal_hypothalamus_physiol1.41358144
61MP0000537_abnormal_urethra_morphology1.39575751
62MP0002723_abnormal_immune_serum1.39018082
63MP0002148_abnormal_hypersensitivity_rea1.37912222
64MP0009333_abnormal_splenocyte_physiolog1.37897934
65MP0002152_abnormal_brain_morphology1.37585581
66MP0009785_altered_susceptibility_to1.37520589
67MP0008789_abnormal_olfactory_epithelium1.36141099
68MP0001944_abnormal_pancreas_morphology1.35851268
69MP0002751_abnormal_autonomic_nervous1.34741485
70MP0005025_abnormal_response_to1.34067851
71MP0000013_abnormal_adipose_tissue1.33725858
72MP0001905_abnormal_dopamine_level1.31932017
73MP0002693_abnormal_pancreas_physiology1.31304130
74MP0003861_abnormal_nervous_system1.31221071
75MP0003329_amyloid_beta_deposits1.29848475
76MP0005174_abnormal_tail_pigmentation1.28989580
77MP0003879_abnormal_hair_cell1.28700286
78MP0000015_abnormal_ear_pigmentation1.28071009
79MP0005386_behavior/neurological_phenoty1.26459736
80MP0004924_abnormal_behavior1.26459736
81MP0002066_abnormal_motor_capabilities/c1.24104529
82MP0002736_abnormal_nociception_after1.23962950
83MP0002452_abnormal_antigen_presenting1.22920982
84MP0002277_abnormal_respiratory_mucosa1.22476966
85MP0002420_abnormal_adaptive_immunity1.22473501
86MP0001819_abnormal_immune_cell1.19818451
87MP0002254_reproductive_system_inflammat1.18429888
88MP0005167_abnormal_blood-brain_barrier1.16090794
89MP0003942_abnormal_urinary_system1.16016075
90MP0002234_abnormal_pharynx_morphology1.15577223
91MP0006082_CNS_inflammation1.15568249
92MP0001835_abnormal_antigen_presentation1.14839459
93MP0010030_abnormal_orbit_morphology1.14751650
94MP0005646_abnormal_pituitary_gland1.14714008
95MP0002138_abnormal_hepatobiliary_system1.13444610
96MP0000534_abnormal_ureter_morphology1.11923062
97MP0003890_abnormal_embryonic-extraembry1.11805554
98MP0004133_heterotaxia1.11169774
99MP0002752_abnormal_somatic_nervous1.11057910
100MP0008569_lethality_at_weaning1.10562761
101MP0003787_abnormal_imprinting1.09127949
102MP0001188_hyperpigmentation1.04135572
103MP0002822_catalepsy1.04035771
104MP0001348_abnormal_lacrimal_gland1.02535413
105MP0003183_abnormal_peptide_metabolism1.01653026
106MP0005377_hearing/vestibular/ear_phenot1.01415815
107MP0003878_abnormal_ear_physiology1.01415815
108MP0008961_abnormal_basal_metabolism1.01176705
109MP0005187_abnormal_penis_morphology1.01071624
110MP0000049_abnormal_middle_ear1.00824827
111MP0005623_abnormal_meninges_morphology0.99994359
112MP0001502_abnormal_circadian_rhythm0.99380883
113MP0000678_abnormal_parathyroid_gland0.98344658
114MP0002249_abnormal_larynx_morphology0.97949680
115MP0003385_abnormal_body_wall0.96869816
116MP0001984_abnormal_olfaction0.96272270
117MP0001501_abnormal_sleep_pattern0.95972559
118MP0000716_abnormal_immune_system0.95701419
119MP0009840_abnormal_foam_cell0.95601860
120MP0004742_abnormal_vestibular_system0.95500037
121MP0004142_abnormal_muscle_tone0.94213484
122MP0005220_abnormal_exocrine_pancreas0.91997376
123MP0002405_respiratory_system_inflammati0.90954223
124MP0003634_abnormal_glial_cell0.89430329
125MP0000538_abnormal_urinary_bladder0.89029249
126MP0002069_abnormal_eating/drinking_beha0.88830461
127MP0004145_abnormal_muscle_electrophysio0.86976788
128MP0002081_perinatal_lethality0.85911530
129MP0009278_abnormal_bone_marrow0.85329459
130MP0004043_abnormal_pH_regulation0.84600180
131MP0000470_abnormal_stomach_morphology0.84408749
132MP0003121_genomic_imprinting0.82844163
133MP0010386_abnormal_urinary_bladder0.82597121
134MP0002638_abnormal_pupillary_reflex0.82587407
135MP0005367_renal/urinary_system_phenotyp0.82452967
136MP0000516_abnormal_urinary_system0.82452967
137MP0003938_abnormal_ear_development0.82310373
138MP0008877_abnormal_DNA_methylation0.82298954
139MP0001663_abnormal_digestive_system0.82019756
140MP0002419_abnormal_innate_immunity0.81386291
141MP0002116_abnormal_craniofacial_bone0.81371385
142MP0004130_abnormal_muscle_cell0.81332857
143MP0003755_abnormal_palate_morphology0.79527213
144MP0000613_abnormal_salivary_gland0.79253916
145MP0009764_decreased_sensitivity_to0.78941710
146MP0002933_joint_inflammation0.77615656
147MP0002398_abnormal_bone_marrow0.77423978
148MP0001845_abnormal_inflammatory_respons0.77322950
149MP0003724_increased_susceptibility_to0.76428091
150MP0001485_abnormal_pinna_reflex0.76165329
151MP0010234_abnormal_vibrissa_follicle0.75915207
152MP0005076_abnormal_cell_differentiation0.75476758
153MP0001299_abnormal_eye_distance/0.75463797
154MP0001943_abnormal_respiration0.73922067
155MP0000026_abnormal_inner_ear0.73620277
156MP0005551_abnormal_eye_electrophysiolog0.73005439
157MP0000751_myopathy0.71784931
158MP0002229_neurodegeneration0.70508588
159MP0000462_abnormal_digestive_system0.70099829
160MP0001529_abnormal_vocalization0.69791561
161MP0001340_abnormal_eyelid_morphology0.69402021

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.38960354
2Visual hallucinations (HP:0002367)4.06669677
3Focal motor seizures (HP:0011153)3.41588881
4Limb dystonia (HP:0002451)3.30268584
5Congenital stationary night blindness (HP:0007642)3.27171907
6Focal seizures (HP:0007359)3.26593712
7Neoplasm of the adrenal cortex (HP:0100641)3.13144176
8Hyperventilation (HP:0002883)3.09889073
9Megalencephaly (HP:0001355)3.04842996
10Stomatitis (HP:0010280)3.04458639
11Supranuclear gaze palsy (HP:0000605)2.97589600
12Obstructive sleep apnea (HP:0002870)2.96091792
13Amyotrophic lateral sclerosis (HP:0007354)2.92140261
14Failure to thrive in infancy (HP:0001531)2.91377433
15Epileptic encephalopathy (HP:0200134)2.80410401
16Increased neuronal autofluorescent lipopigment (HP:0002074)2.77809001
17Mutism (HP:0002300)2.77173527
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76526522
19Concave nail (HP:0001598)2.73803180
20Amblyopia (HP:0000646)2.72276985
21Atonic seizures (HP:0010819)2.67647109
22Cerebral inclusion bodies (HP:0100314)2.67229530
23Abnormality of glycolipid metabolism (HP:0010969)2.67184459
24Abnormality of liposaccharide metabolism (HP:0010968)2.67184459
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.67184459
26Increased cerebral lipofuscin (HP:0011813)2.65580613
27Clumsiness (HP:0002312)2.63966439
28Type II lissencephaly (HP:0007260)2.60586532
29Agitation (HP:0000713)2.57550803
30Hyperthyroidism (HP:0000836)2.55763678
31Absent speech (HP:0001344)2.52970539
32Action tremor (HP:0002345)2.45610370
33Congenital malformation of the right heart (HP:0011723)2.45462780
34Double outlet right ventricle (HP:0001719)2.45462780
35Decreased circulating renin level (HP:0003351)2.44003343
36Akinesia (HP:0002304)2.42886020
37Abnormality of polysaccharide metabolism (HP:0011012)2.42450595
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42450595
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42450595
40Optic neuritis (HP:0100653)2.40771367
41Retrobulbar optic neuritis (HP:0100654)2.40771367
42Absence seizures (HP:0002121)2.39412392
43Abnormality of the corticospinal tract (HP:0002492)2.37412143
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36948675
45Hypercortisolism (HP:0001578)2.35833524
46Tented upper lip vermilion (HP:0010804)2.35693101
47Progressive cerebellar ataxia (HP:0002073)2.35476483
48Limb hypertonia (HP:0002509)2.35251523
49Abnormality of the lower motor neuron (HP:0002366)2.31753774
50Elevated erythrocyte sedimentation rate (HP:0003565)2.30386538
51Broad-based gait (HP:0002136)2.30127700
52Mesangial abnormality (HP:0001966)2.29880059
53Insomnia (HP:0100785)2.29825110
54Orchitis (HP:0100796)2.26818672
55Dysostosis multiplex (HP:0000943)2.26789632
56Myositis (HP:0100614)2.26312659
57Gastrointestinal stroma tumor (HP:0100723)2.25279141
58Abnormal drinking behavior (HP:0030082)2.23517153
59Polydipsia (HP:0001959)2.23517153
60Drooling (HP:0002307)2.23226567
61Excessive salivation (HP:0003781)2.23226567
62Mediastinal lymphadenopathy (HP:0100721)2.23092459
63Genetic anticipation (HP:0003743)2.22066404
64Hemiparesis (HP:0001269)2.22004039
65Recurrent bacterial skin infections (HP:0005406)2.21277597
66Hyperacusis (HP:0010780)2.20355968
67EEG with generalized epileptiform discharges (HP:0011198)2.19381179
68Depression (HP:0000716)2.18559819
69Apathy (HP:0000741)2.17259055
70Neurofibrillary tangles (HP:0002185)2.16919413
71Papilledema (HP:0001085)2.16751011
72Hypsarrhythmia (HP:0002521)2.16660608
73Termporal pattern (HP:0011008)2.15929800
74Insidious onset (HP:0003587)2.15929800
75Epileptiform EEG discharges (HP:0011182)2.13994386
76Fetal akinesia sequence (HP:0001989)2.13768770
77Ankle clonus (HP:0011448)2.10467208
78Poor eye contact (HP:0000817)2.07074828
79Febrile seizures (HP:0002373)2.06016453
80Gastrointestinal infarctions (HP:0005244)2.05616358
81Hypochromic anemia (HP:0001931)2.05080100
82Abnormal rod and cone electroretinograms (HP:0008323)2.03959270
83Dialeptic seizures (HP:0011146)2.03581051
84Hypoventilation (HP:0002791)2.03375825
85Molar tooth sign on MRI (HP:0002419)2.03108243
86Abnormality of midbrain morphology (HP:0002418)2.03108243
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01465283
88Bronchomalacia (HP:0002780)2.01374443
89Annular pancreas (HP:0001734)2.01347246
90Abnormality of the astrocytes (HP:0100707)2.01147791
91Astrocytoma (HP:0009592)2.01147791
92Progressive microcephaly (HP:0000253)2.00350275
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00069897
94Hypoplasia of the brainstem (HP:0002365)2.00069897
95Turricephaly (HP:0000262)1.99985490
96Retinal dysplasia (HP:0007973)1.99166261
97Mucopolysacchariduria (HP:0008155)1.97545287
98Urinary glycosaminoglycan excretion (HP:0003541)1.97545287
99Abnormality of the aortic arch (HP:0012303)1.96898600
100Diminished motivation (HP:0000745)1.94286803
101Morphological abnormality of the middle ear (HP:0008609)1.94276837
102Deep palmar crease (HP:0006191)1.94069185
103Intellectual disability, severe (HP:0010864)1.93411496
104Testicular atrophy (HP:0000029)1.93238839
105Ocular albinism (HP:0001107)1.92949699
106Melanoma (HP:0002861)1.92864269
107Meningitis (HP:0001287)1.92066305
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92007562
109Morphological abnormality of the pyramidal tract (HP:0002062)1.91441447
110Choanal stenosis (HP:0000452)1.91153762
111Truncus arteriosus (HP:0001660)1.90916271
112Abnormal social behavior (HP:0012433)1.90394586
113Impaired social interactions (HP:0000735)1.90394586
114Inappropriate behavior (HP:0000719)1.90209228
115Sporadic (HP:0003745)1.88973099
116Neoplasm of the heart (HP:0100544)1.88801435
117Abnormality of lateral ventricle (HP:0030047)1.88281958
118Restlessness (HP:0000711)1.88007818
119Elfin facies (HP:0004428)1.87543437
120J-shaped sella turcica (HP:0002680)1.87487080
121Polyphagia (HP:0002591)1.87295708
122Macroorchidism (HP:0000053)1.86273598
123Pendular nystagmus (HP:0012043)1.85915634
124Iris hypopigmentation (HP:0007730)1.85733926
125Large eyes (HP:0001090)1.85632930
126Hyperparathyroidism (HP:0000843)1.84600970
127Loss of speech (HP:0002371)1.84236947
128Congenital glaucoma (HP:0001087)1.84111909
129Vasculitis (HP:0002633)1.83237900
130Easy fatigability (HP:0003388)1.83184428
131Generalized tonic-clonic seizures (HP:0002069)1.82734770
132Albinism (HP:0001022)1.82685008
133Dysdiadochokinesis (HP:0002075)1.82563520
134Pointed chin (HP:0000307)1.80273505
135Spastic gait (HP:0002064)1.79661593
136Generalized hypotonia (HP:0001290)1.79632157
137Abnormal eating behavior (HP:0100738)1.79446923
138Esotropia (HP:0000565)1.79442262
139Anxiety (HP:0000739)1.79373498
140Rib fusion (HP:0000902)1.78809184
141Stereotypic behavior (HP:0000733)1.77750786
142Lissencephaly (HP:0001339)1.77399686
143Macroglossia (HP:0000158)1.76358203
144Rectal prolapse (HP:0002035)1.76280131
145Urinary bladder sphincter dysfunction (HP:0002839)1.75703015
146Recurrent abscess formation (HP:0002722)1.75575999
147Bilateral microphthalmos (HP:0007633)1.75575945
148Renal duplication (HP:0000075)1.75541448
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75374148
150Protruding tongue (HP:0010808)1.73940620
151Thin bony cortex (HP:0002753)1.73610911
152Bowel incontinence (HP:0002607)1.72873560
153Severe visual impairment (HP:0001141)1.72685100
154Germ cell neoplasia (HP:0100728)1.72336394
155Vacuolated lymphocytes (HP:0001922)1.72285553
156Sleep apnea (HP:0010535)1.72181791
157Stridor (HP:0010307)1.72059224
158Recurrent fungal infections (HP:0002841)1.71600310
159Urinary urgency (HP:0000012)1.71578648
160Nephronophthisis (HP:0000090)1.71270122
161Overgrowth (HP:0001548)1.70795809
162Ankyloglossia (HP:0010296)1.69622989
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.69621291
16411 pairs of ribs (HP:0000878)1.68412994
165Abnormality of macrophages (HP:0004311)1.68243165
166Hamartoma of the eye (HP:0010568)1.68144567
167Adenoma sebaceum (HP:0009720)1.68051280
168Angiofibromas (HP:0010615)1.68051280
169Nasal polyposis (HP:0100582)1.67459325
170Cutaneous finger syndactyly (HP:0010554)1.67170942
171Rapidly progressive (HP:0003678)1.67030910
172Encephalitis (HP:0002383)1.66724633
173Microretrognathia (HP:0000308)1.66361310
174Bony spicule pigmentary retinopathy (HP:0007737)1.65859323
175Pheochromocytoma (HP:0002666)1.65639581
176Torticollis (HP:0000473)1.65619311
177Hamartoma (HP:0010566)1.64573066
178Recurrent cutaneous fungal infections (HP:0011370)1.64354691
179Impaired vibration sensation in the lower limbs (HP:0002166)1.62247624
180Sacral dimple (HP:0000960)1.62008804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.60076341
2MAP3K93.73118564
3MAP4K12.94108353
4SIK12.63936236
5NTRK32.63394450
6ERN12.60971856
7MAP3K42.44518963
8ICK2.42476584
9TYRO32.27607211
10IRAK32.23856801
11LATS22.18856125
12PHKG22.14650872
13PHKG12.14650872
14UHMK12.11018861
15NTRK22.02458626
16IRAK42.02198896
17MINK11.96841597
18PAK61.95621677
19TNK21.90040461
20DYRK21.86064050
21SIK21.82102202
22NTRK11.72460579
23KSR21.67135931
24CASK1.66232246
25MAP3K21.64930960
26PNCK1.63202675
27SIK31.60693797
28YES11.60628059
29EPHA41.60222848
30TAOK11.54730268
31ERBB31.53757731
32DDR21.53161101
33ADRBK21.50110352
34BLK1.49965478
35MAPK131.49117175
36IRAK21.48914725
37DAPK21.47056035
38MAP2K71.42199734
39MAP2K61.41061010
40KSR11.39113045
41TAOK31.38961657
42MAPK151.35408590
43TYK21.30663985
44CAMKK11.30416090
45CDK51.28780774
46PRKD31.23991441
47MUSK1.20913359
48IKBKB1.20755602
49GRK51.20272214
50MARK21.18565663
51SMG11.15077447
52MAP3K61.14054704
53DAPK11.13761149
54PDGFRA1.10731022
55MAP2K31.10293709
56MAP2K41.08150307
57IKBKE1.08118538
58TXK1.06673309
59IRAK11.05937832
60EPHB21.02540863
61TRIB31.02016632
62CHUK1.01436908
63WNK31.01100401
64LIMK10.99916850
65ALK0.99903821
66PAK30.99132046
67PRKD20.98728528
68CSNK1G20.98515485
69TBK10.96193542
70NME20.95937194
71RET0.95218865
72STK110.92547602
73TLK10.91481815
74WNK40.89634914
75MARK30.88916933
76CAMK1G0.87819409
77HIPK20.87106562
78PTK60.86465735
79FGR0.85387020
80PLK20.82714317
81CDK140.82340801
82CDC42BPA0.82283897
83CDK150.81971569
84MAP3K30.81732737
85PRKCG0.78028040
86CDK180.77471092
87STK160.76975033
88TAOK20.76867204
89CDK11A0.75076406
90SYK0.74359397
91MAP3K100.73704413
92PTK20.73065365
93CAMKK20.72102458
94ITK0.71032476
95STK380.70684827
96SCYL20.70043951
97CSNK1G30.69618114
98DYRK1A0.69194016
99RPS6KA20.68839666
100LYN0.68810387
101CSK0.68573815
102DYRK1B0.68365834
103CAMK2A0.68204646
104MAPK120.67900979
105PRKCI0.67484054
106RIPK10.66165231
107CDK190.65698118
108MAP3K10.65674686
109GRK60.65634046
110MAP2K20.64651620
111PRKCZ0.62921832
112BTK0.61628100
113PRKCQ0.59337005
114RIPK40.59121523
115CAMK2B0.58589703
116LRRK20.57900620
117EEF2K0.57674006
118RPS6KB10.55819820
119PDK10.55145261
120BMX0.53817763
121CSNK1G10.53742934
122MAPK110.53439017
123RPS6KA60.53161329
124ADRBK10.49550829
125PKN20.47016553
126SGK2230.46990521
127SGK4940.46990521
128RPS6KL10.46972457
129RPS6KC10.46972457
130GSK3A0.46586019
131SGK30.44842033
132CSF1R0.44722210
133LCK0.44548809
134PDPK10.44435510
135MAP3K140.44177383
136CSNK1A1L0.43865592
137FER0.43106315
138HCK0.42790133
139CSNK1E0.41326405
140PKN10.40831985
141MAPK90.40180869
142MAPK40.39622720
143CAMK40.37818923
144MAPK80.37711489
145PIM10.36758250
146SGK10.36323244
147GRK70.35468885
148MAP3K110.35448291
149MATK0.35069445
150RPS6KA10.34503050
151ILK0.34402125
152ERBB20.34400342
153MAPK100.34044098
154PRKCH0.32935934
155PRPF4B0.32887183
156PTK2B0.32865541
157RPS6KA30.31521198
158MTOR0.31185824
159NME10.30713945

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.64039199
2Synaptic vesicle cycle_Homo sapiens_hsa047212.60134627
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36019964
4Long-term potentiation_Homo sapiens_hsa047202.18983859
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10455028
6Primary immunodeficiency_Homo sapiens_hsa053402.08525631
7GABAergic synapse_Homo sapiens_hsa047272.05232973
8T cell receptor signaling pathway_Homo sapiens_hsa046602.03511940
9Dopaminergic synapse_Homo sapiens_hsa047282.03055524
10Circadian entrainment_Homo sapiens_hsa047131.98580288
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94047232
12Amphetamine addiction_Homo sapiens_hsa050311.90094574
13Insulin secretion_Homo sapiens_hsa049111.89640208
14Olfactory transduction_Homo sapiens_hsa047401.89608342
15Glutamatergic synapse_Homo sapiens_hsa047241.88616176
16B cell receptor signaling pathway_Homo sapiens_hsa046621.87807020
17Gap junction_Homo sapiens_hsa045401.87036418
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85049431
19Morphine addiction_Homo sapiens_hsa050321.80777924
20Axon guidance_Homo sapiens_hsa043601.80118085
21Cholinergic synapse_Homo sapiens_hsa047251.79930167
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79281830
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.76405678
24Long-term depression_Homo sapiens_hsa047301.72646605
25Cocaine addiction_Homo sapiens_hsa050301.70492620
26Type I diabetes mellitus_Homo sapiens_hsa049401.67167081
27Allograft rejection_Homo sapiens_hsa053301.66502613
28Osteoclast differentiation_Homo sapiens_hsa043801.65935331
29Other glycan degradation_Homo sapiens_hsa005111.54138193
30Estrogen signaling pathway_Homo sapiens_hsa049151.51584874
31Taste transduction_Homo sapiens_hsa047421.50743217
32Autoimmune thyroid disease_Homo sapiens_hsa053201.50348678
33Glioma_Homo sapiens_hsa052141.49033391
34Type II diabetes mellitus_Homo sapiens_hsa049301.46897109
35GnRH signaling pathway_Homo sapiens_hsa049121.46766408
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46700078
37Serotonergic synapse_Homo sapiens_hsa047261.46381656
38Salivary secretion_Homo sapiens_hsa049701.45017783
39Melanogenesis_Homo sapiens_hsa049161.43057956
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42576674
41ErbB signaling pathway_Homo sapiens_hsa040121.41554150
42Gastric acid secretion_Homo sapiens_hsa049711.40329282
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.40269043
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39431481
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.36712794
46Graft-versus-host disease_Homo sapiens_hsa053321.34333570
47Oxytocin signaling pathway_Homo sapiens_hsa049211.32793410
48Renin secretion_Homo sapiens_hsa049241.29269462
49mTOR signaling pathway_Homo sapiens_hsa041501.28056619
50Hedgehog signaling pathway_Homo sapiens_hsa043401.27468953
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24889613
52Endometrial cancer_Homo sapiens_hsa052131.24054563
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21111275
54Measles_Homo sapiens_hsa051621.20242969
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19546449
56Lysosome_Homo sapiens_hsa041421.17522603
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14831135
58Leishmaniasis_Homo sapiens_hsa051401.12614049
59VEGF signaling pathway_Homo sapiens_hsa043701.12132218
60Sulfur relay system_Homo sapiens_hsa041221.11157960
61Rheumatoid arthritis_Homo sapiens_hsa053231.10085633
62Chemokine signaling pathway_Homo sapiens_hsa040621.09935198
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09840904
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09791660
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09650793
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09371553
67Renal cell carcinoma_Homo sapiens_hsa052111.09328475
68TNF signaling pathway_Homo sapiens_hsa046681.06281287
69Wnt signaling pathway_Homo sapiens_hsa043101.05572647
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04734048
71Dorso-ventral axis formation_Homo sapiens_hsa043201.04720196
72Hippo signaling pathway_Homo sapiens_hsa043901.00985443
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00476871
74Acute myeloid leukemia_Homo sapiens_hsa052210.99775513
75Colorectal cancer_Homo sapiens_hsa052100.99607755
76Tuberculosis_Homo sapiens_hsa051520.98393392
77Collecting duct acid secretion_Homo sapiens_hsa049660.98367280
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95755397
79Phototransduction_Homo sapiens_hsa047440.95511994
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95228204
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95081641
82Oocyte meiosis_Homo sapiens_hsa041140.94879585
83Basal cell carcinoma_Homo sapiens_hsa052170.94000051
84Choline metabolism in cancer_Homo sapiens_hsa052310.93760566
85Cardiac muscle contraction_Homo sapiens_hsa042600.92818504
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92718308
87Hepatitis C_Homo sapiens_hsa051600.91369665
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.89602582
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.89197507
90Calcium signaling pathway_Homo sapiens_hsa040200.88813343
91Asthma_Homo sapiens_hsa053100.87762596
92Vibrio cholerae infection_Homo sapiens_hsa051100.87328046
93cAMP signaling pathway_Homo sapiens_hsa040240.86525181
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84881088
95Insulin signaling pathway_Homo sapiens_hsa049100.84825811
96MAPK signaling pathway_Homo sapiens_hsa040100.83736660
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83066223
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.82647675
99Hepatitis B_Homo sapiens_hsa051610.82383303
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81616063
101Influenza A_Homo sapiens_hsa051640.80116723
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78727568
103Bladder cancer_Homo sapiens_hsa052190.78074523
104Alcoholism_Homo sapiens_hsa050340.77931860
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.77122442
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76379094
107Non-small cell lung cancer_Homo sapiens_hsa052230.75262013
108Ras signaling pathway_Homo sapiens_hsa040140.74219776
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.73711424
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72879254
111Rap1 signaling pathway_Homo sapiens_hsa040150.72511543
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.71852180
113Ether lipid metabolism_Homo sapiens_hsa005650.71543101
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71470251
115Prolactin signaling pathway_Homo sapiens_hsa049170.70856945
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69452397
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69251419
118Chronic myeloid leukemia_Homo sapiens_hsa052200.68901593
119Tight junction_Homo sapiens_hsa045300.68480672
120FoxO signaling pathway_Homo sapiens_hsa040680.68207702
121Pancreatic cancer_Homo sapiens_hsa052120.68086850
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67839144
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67825735
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.67621321
125Inositol phosphate metabolism_Homo sapiens_hsa005620.67261327
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67167359
127Thyroid hormone synthesis_Homo sapiens_hsa049180.66537604
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66254163
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65970233
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65321289
131Herpes simplex infection_Homo sapiens_hsa051680.64696186
132African trypanosomiasis_Homo sapiens_hsa051430.64061435
133Melanoma_Homo sapiens_hsa052180.62089147
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60201726
135Toxoplasmosis_Homo sapiens_hsa051450.60128724
136Staphylococcus aureus infection_Homo sapiens_hsa051500.59723037
137Pancreatic secretion_Homo sapiens_hsa049720.59559041
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58950878
139Prion diseases_Homo sapiens_hsa050200.56923836
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56905206
141Glucagon signaling pathway_Homo sapiens_hsa049220.56849482
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56671514
143Dilated cardiomyopathy_Homo sapiens_hsa054140.55815611
144Notch signaling pathway_Homo sapiens_hsa043300.55520055
145Endocytosis_Homo sapiens_hsa041440.52781334
146Thyroid cancer_Homo sapiens_hsa052160.52756116
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49134229
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48375744
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47813164
150Adherens junction_Homo sapiens_hsa045200.47469835
151AMPK signaling pathway_Homo sapiens_hsa041520.44029414
152Alzheimers disease_Homo sapiens_hsa050100.42570340

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