MARCH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.23166385
2neuron cell-cell adhesion (GO:0007158)5.14431508
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11258118
4protein heterotrimerization (GO:0070208)4.90259264
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89927862
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88651673
7locomotory exploration behavior (GO:0035641)4.76891729
8synaptic vesicle exocytosis (GO:0016079)4.64880531
9synaptic vesicle maturation (GO:0016188)4.64785534
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.63983716
11cell adhesion mediated by integrin (GO:0033627)4.63949075
12protein localization to synapse (GO:0035418)4.57209436
13regulation of glutamate receptor signaling pathway (GO:1900449)4.46617296
14skin morphogenesis (GO:0043589)4.44712936
15regulation of synaptic vesicle exocytosis (GO:2000300)4.41773322
16collagen fibril organization (GO:0030199)4.30311799
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.30188030
18glutamate secretion (GO:0014047)4.24795362
19postsynaptic membrane organization (GO:0001941)4.10172248
20kidney mesenchyme development (GO:0072074)4.09349414
21exploration behavior (GO:0035640)4.05406246
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.03087042
23substrate-dependent cell migration (GO:0006929)4.01986016
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.99787637
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95441353
26endodermal cell differentiation (GO:0035987)3.93883083
27layer formation in cerebral cortex (GO:0021819)3.92305760
28regulation of synaptic vesicle transport (GO:1902803)3.92175257
29dendritic spine morphogenesis (GO:0060997)3.88221481
30chondrocyte proliferation (GO:0035988)3.87247288
31neurotransmitter secretion (GO:0007269)3.78809572
32neurotransmitter-gated ion channel clustering (GO:0072578)3.78234533
33pyrimidine nucleobase catabolic process (GO:0006208)3.74886916
34synaptic transmission, glutamatergic (GO:0035249)3.74334144
35neuron recognition (GO:0008038)3.71457221
36glutamate receptor signaling pathway (GO:0007215)3.70917001
37type B pancreatic cell proliferation (GO:0044342)3.68710678
38regulation of synapse structural plasticity (GO:0051823)3.65804608
39proline transport (GO:0015824)3.65155685
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64037947
41response to pheromone (GO:0019236)3.63370297
42neuron-neuron synaptic transmission (GO:0007270)3.61048393
43bone trabecula formation (GO:0060346)3.60096090
44presynaptic membrane assembly (GO:0097105)3.57204381
45auditory behavior (GO:0031223)3.54161572
46regulation of neuronal synaptic plasticity (GO:0048168)3.54137832
47cellular response to vitamin (GO:0071295)3.53861395
48axonal fasciculation (GO:0007413)3.51863695
49positive regulation of axon extension (GO:0045773)3.51330185
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50887324
51cellular response to vitamin D (GO:0071305)3.48397637
52response to auditory stimulus (GO:0010996)3.45448814
53axon extension (GO:0048675)3.44276651
54sequestering of extracellular ligand from receptor (GO:0035581)3.42656403
55dendrite morphogenesis (GO:0048813)3.38858914
56detection of calcium ion (GO:0005513)3.38462664
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.37615106
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37014925
59synapse assembly (GO:0007416)3.36419677
60synaptic vesicle endocytosis (GO:0048488)3.32208011
61long-term memory (GO:0007616)3.29948349
62central nervous system projection neuron axonogenesis (GO:0021952)3.29205733
63gamma-aminobutyric acid transport (GO:0015812)3.28665591
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28445661
65presynaptic membrane organization (GO:0097090)3.26697233
66regulation of neurotransmitter secretion (GO:0046928)3.23769909
67regulation of vesicle fusion (GO:0031338)3.23748126
68positive regulation of neurotransmitter secretion (GO:0001956)3.21409664
69transmission of nerve impulse (GO:0019226)3.21353395
70metanephric mesenchyme development (GO:0072075)3.20880798
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20788219
72positive regulation of synapse maturation (GO:0090129)3.20350031
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20213070
74cell migration involved in sprouting angiogenesis (GO:0002042)3.19793616
75positive regulation of membrane potential (GO:0045838)3.18907095
76neuron projection extension (GO:1990138)3.18781393
77innervation (GO:0060384)3.17902835
78neurotransmitter transport (GO:0006836)3.15090717
79response to gravity (GO:0009629)3.13952340
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12622878
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.10899601
82cell migration in hindbrain (GO:0021535)3.08478233
83regulation of postsynaptic membrane potential (GO:0060078)3.08465780
84regulation of axon extension involved in axon guidance (GO:0048841)3.07794983
85neuronal action potential propagation (GO:0019227)3.07749425
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05409195
87positive regulation of fibroblast migration (GO:0010763)3.05366945
88positive regulation of neurotransmitter transport (GO:0051590)3.03523551
89regulation of synapse maturation (GO:0090128)3.02921539
90regulation of neurotransmitter transport (GO:0051588)3.01671165
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.99621529
92actin filament depolymerization (GO:0030042)2.99617327
93extracellular matrix assembly (GO:0085029)2.99312644
94protein retention in ER lumen (GO:0006621)2.99257729
95nucleobase catabolic process (GO:0046113)2.98984693
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98920488
97virion attachment to host cell (GO:0019062)2.98613374
98adhesion of symbiont to host cell (GO:0044650)2.98613374
99mechanosensory behavior (GO:0007638)2.97574686
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97200793
101long-term synaptic potentiation (GO:0060291)2.95769653
102startle response (GO:0001964)2.95200988
103positive regulation of blood vessel endothelial cell migration (GO:0043536)2.94780170
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.94322130
105lymphangiogenesis (GO:0001946)2.94016653
106glycine transport (GO:0015816)2.93786373
107cell migration involved in heart development (GO:0060973)2.93569357
108response to histamine (GO:0034776)2.92656399
109negative regulation of axon extension involved in axon guidance (GO:0048843)2.91904261
110regulation of synaptic plasticity (GO:0048167)2.91173375
111inner ear receptor cell development (GO:0060119)2.90500221
112paraxial mesoderm development (GO:0048339)2.90211909
113learning (GO:0007612)2.88863104
114protein localization to endosome (GO:0036010)2.88599847
115endocardial cushion development (GO:0003197)2.88523613
116regulation of synaptic transmission, GABAergic (GO:0032228)2.88145368
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87984770
118dendritic spine organization (GO:0097061)2.85733167
119behavioral response to ethanol (GO:0048149)2.85422805
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.84982513
121regulation of neurotransmitter levels (GO:0001505)2.84718364
122cerebral cortex radially oriented cell migration (GO:0021799)2.84193936
123regulation of axon guidance (GO:1902667)2.82175979
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79972252
125dopamine receptor signaling pathway (GO:0007212)2.79605604
126cerebellum development (GO:0021549)2.79103328
127prepulse inhibition (GO:0060134)2.79037367
128dendrite development (GO:0016358)2.78943797
129wound healing, spreading of epidermal cells (GO:0035313)2.77578987
130heparan sulfate proteoglycan metabolic process (GO:0030201)2.77248816
131stress fiber assembly (GO:0043149)2.76702292
132social behavior (GO:0035176)2.75698079
133intraspecies interaction between organisms (GO:0051703)2.75698079
134activation of protein kinase A activity (GO:0034199)2.75397196
135female mating behavior (GO:0060180)2.74722335
136regulation of dendritic spine morphogenesis (GO:0061001)2.74273123
137negative regulation of osteoblast proliferation (GO:0033689)2.74229685
138negative regulation of smooth muscle cell migration (GO:0014912)2.74007423
139positive regulation of synapse assembly (GO:0051965)2.73790776
140regulation of respiratory system process (GO:0044065)2.73357219
141central nervous system neuron axonogenesis (GO:0021955)2.73285081
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.73273976
143membrane depolarization (GO:0051899)2.72814092
144membrane depolarization during action potential (GO:0086010)2.72497586
145negative regulation of nitric-oxide synthase activity (GO:0051001)2.68876676
146cell-substrate junction assembly (GO:0007044)2.66892069
147collagen metabolic process (GO:0032963)2.66746898
148regulation of plasminogen activation (GO:0010755)2.65921074
149cranial nerve morphogenesis (GO:0021602)2.65254322
150positive regulation of catecholamine secretion (GO:0033605)2.63947373
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61942312
152mesenchymal-epithelial cell signaling (GO:0060638)2.61876161
153dermatan sulfate biosynthetic process (GO:0030208)2.60528766
154axon extension involved in axon guidance (GO:0048846)2.58410135
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.58410135
156proteoglycan biosynthetic process (GO:0030166)2.58040326
157regulation of axon extension (GO:0030516)2.57625285
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55947131
159negative regulation of axon guidance (GO:1902668)2.55200477
160collagen catabolic process (GO:0030574)2.51541161
161basement membrane organization (GO:0071711)2.51045134
162negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.48714234
163cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.48572434
164mesodermal cell differentiation (GO:0048333)2.48448706
165multicellular organismal macromolecule metabolic process (GO:0044259)2.46021067
166regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45533208
167negative regulation of chondrocyte differentiation (GO:0032331)2.45471853
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.45079531
169developmental cell growth (GO:0048588)2.44519330
170dermatan sulfate metabolic process (GO:0030205)2.44418438
171sprouting angiogenesis (GO:0002040)2.44125223
172COPI coating of Golgi vesicle (GO:0048205)2.43813975
173Golgi transport vesicle coating (GO:0048200)2.43813975
174blood vessel maturation (GO:0001955)2.43801714
175positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41111833
176adherens junction assembly (GO:0034333)2.40802944
177cochlea morphogenesis (GO:0090103)2.38992515
178wound healing, spreading of cells (GO:0044319)2.38477556
179dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.38165180
180barbed-end actin filament capping (GO:0051016)2.38052136
181adhesion of symbiont to host (GO:0044406)2.37696090
182regulation of type B pancreatic cell apoptotic process (GO:2000674)2.36449987
183pericardium development (GO:0060039)2.36441272
184lens morphogenesis in camera-type eye (GO:0002089)2.36218011
185hippo signaling (GO:0035329)2.35775879
186ganglion development (GO:0061548)2.35630753
187actin filament bundle organization (GO:0061572)2.35592639
188actin filament bundle assembly (GO:0051017)2.35592639
189endocytic recycling (GO:0032456)2.34348049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69442839
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.27065476
3GBX2_23144817_ChIP-Seq_PC3_Human3.86523503
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28804435
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91552447
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86381602
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79051848
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72367828
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.64007164
10REST_21632747_ChIP-Seq_MESCs_Mouse2.60548769
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54529963
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44417848
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42448838
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41427202
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39800797
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39800797
17BRD4_25478319_ChIP-Seq_HGPS_Human2.36272350
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33509697
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30479249
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28381324
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.21660440
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20376534
23DROSHA_22980978_ChIP-Seq_HELA_Human2.19873423
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.19742749
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.09591794
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09318999
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08761736
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98680333
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96392738
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95115449
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.93558535
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.93329422
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91609653
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91328829
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90050125
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89498733
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87733347
38CJUN_26792858_Chip-Seq_BT549_Human1.87721129
39IGF1R_20145208_ChIP-Seq_DFB_Human1.87674714
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84727014
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.82616264
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80033029
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75937718
44AR_21572438_ChIP-Seq_LNCaP_Human1.74812630
45SMAD4_21799915_ChIP-Seq_A2780_Human1.74330424
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74046635
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71875574
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71007120
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70741543
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65879853
51TAF15_26573619_Chip-Seq_HEK293_Human1.64160977
52P300_19829295_ChIP-Seq_ESCs_Human1.61010606
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.59630268
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.56400755
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54911625
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49788610
57TP53_22127205_ChIP-Seq_IMR90_Human1.47790063
58RNF2_27304074_Chip-Seq_NSC_Mouse1.43984896
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43026048
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.42594138
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.42134055
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39673537
63TP53_16413492_ChIP-PET_HCT116_Human1.38318867
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.37796532
65TP53_23651856_ChIP-Seq_MEFs_Mouse1.37440598
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36674220
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36660002
68STAT3_23295773_ChIP-Seq_U87_Human1.36370808
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35980468
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35891177
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35705732
72AR_25329375_ChIP-Seq_VCAP_Human1.35536618
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35305914
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35202271
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34427592
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32459223
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32459223
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.30868968
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28546185
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27990109
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27650571
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27307420
83KDM2B_26808549_Chip-Seq_K562_Human1.26995210
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.25573003
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24996649
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.24886853
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23701880
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23502491
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23410675
90ZNF274_21170338_ChIP-Seq_K562_Hela1.23198437
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22387725
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.21714885
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20858711
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20845299
95TCF4_23295773_ChIP-Seq_U87_Human1.20273968
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.18575583
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18066919
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17482003
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17456215
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17389299
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17389299
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16848382
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16355263
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16299992
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15569752
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.15251044
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15078326
108RUNX2_22187159_ChIP-Seq_PCA_Human1.14860695
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14569051
110AR_19668381_ChIP-Seq_PC3_Human1.14472341
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.13879661
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13498439
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13168481
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12812319
115VDR_22108803_ChIP-Seq_LS180_Human1.12772536
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12519162
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12498500
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12119831
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.12005462
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09686675
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09686675
122FUS_26573619_Chip-Seq_HEK293_Human1.09128981
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08974786
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.07964172
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07214936
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07027905
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05945355
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05904729
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.04476992
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03727487
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02440261
132JUN_21703547_ChIP-Seq_K562_Human1.02010674
133ARNT_22903824_ChIP-Seq_MCF-7_Human1.01924448
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.01681751
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01463524
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00441938
137SA1_22415368_ChIP-Seq_MEFs_Mouse1.00395254
138ER_23166858_ChIP-Seq_MCF-7_Human1.00146019
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.99889168
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99631826
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.99133668
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.98468223
143CLOCK_20551151_ChIP-Seq_293T_Human0.98433144
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98399044
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98080122
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98003821
147TP53_18474530_ChIP-ChIP_U2OS_Human0.97516712
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97469939
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97256545
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97040877
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97024196
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.96754959
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96332847
154EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94110648
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91687896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.32264945
2MP0004859_abnormal_synaptic_plasticity5.14240223
3MP0003705_abnormal_hypodermis_morpholog3.72763773
4MP0003880_abnormal_central_pattern3.71188404
5MP0003635_abnormal_synaptic_transmissio3.51552771
6MP0005623_abnormal_meninges_morphology3.51510259
7MP0003279_aneurysm3.51064797
8MP0004270_analgesia3.48973936
9MP0001958_emphysema3.37900931
10MP0005257_abnormal_intraocular_pressure3.35578981
11MP0005423_abnormal_somatic_nervous3.22244412
12MP0005503_abnormal_tendon_morphology3.16988987
13MP0004272_abnormal_basement_membrane3.11479578
14MP0002063_abnormal_learning/memory/cond2.92409338
15MP0009745_abnormal_behavioral_response2.84687089
16MP0002734_abnormal_mechanical_nocicepti2.79812133
17MP0010368_abnormal_lymphatic_system2.76659604
18MP0001968_abnormal_touch/_nociception2.72201659
19MP0009384_cardiac_valve_regurgitation2.62466362
20MP0002572_abnormal_emotion/affect_behav2.58616816
21MP0002735_abnormal_chemical_nociception2.53742684
22MP0001188_hyperpigmentation2.52736911
23MP0002064_seizures2.50838562
24MP0005275_abnormal_skin_tensile2.50133875
25MP0009780_abnormal_chondrocyte_physiolo2.50012709
26MP0005645_abnormal_hypothalamus_physiol2.44543254
27MP0003566_abnormal_cell_adhesion2.42016302
28MP0009046_muscle_twitch2.37235629
29MP0001486_abnormal_startle_reflex2.36750668
30MP0006276_abnormal_autonomic_nervous2.34565994
31MP0005646_abnormal_pituitary_gland2.33976153
32MP0001542_abnormal_bone_strength2.25463754
33MP0002822_catalepsy2.17620551
34MP0003950_abnormal_plasma_membrane2.13415213
35MP0002733_abnormal_thermal_nociception2.11122291
36MP0002736_abnormal_nociception_after2.09084481
37MP0002272_abnormal_nervous_system2.07598932
38MP0002184_abnormal_innervation2.05086458
39MP0002909_abnormal_adrenal_gland2.02323104
40MP0000778_abnormal_nervous_system2.02266624
41MP0001970_abnormal_pain_threshold2.01864256
42MP0001440_abnormal_grooming_behavior2.00616709
43MP0001348_abnormal_lacrimal_gland2.00530432
44MP0002557_abnormal_social/conspecific_i1.96429480
45MP0010386_abnormal_urinary_bladder1.92977249
46MP0000534_abnormal_ureter_morphology1.90274859
47MP0001501_abnormal_sleep_pattern1.89099128
48MP0006054_spinal_hemorrhage1.84698019
49MP0003091_abnormal_cell_migration1.82697401
50MP0002067_abnormal_sensory_capabilities1.78318235
51MP0001984_abnormal_olfaction1.76921599
52MP0002638_abnormal_pupillary_reflex1.75927711
53MP0003879_abnormal_hair_cell1.74844293
54MP0004924_abnormal_behavior1.72743592
55MP0005386_behavior/neurological_phenoty1.72743592
56MP0000767_abnormal_smooth_muscle1.70116615
57MP0004858_abnormal_nervous_system1.67630667
58MP0004811_abnormal_neuron_physiology1.61728530
59MP0000955_abnormal_spinal_cord1.52193123
60MP0000569_abnormal_digit_pigmentation1.52123577
61MP0001529_abnormal_vocalization1.50370741
62MP0002295_abnormal_pulmonary_circulatio1.50063119
63MP0003787_abnormal_imprinting1.48627056
64MP0001986_abnormal_taste_sensitivity1.47730946
65MP0006292_abnormal_olfactory_placode1.44987572
66MP0001502_abnormal_circadian_rhythm1.44886455
67MP0001905_abnormal_dopamine_level1.44224862
68MP0005508_abnormal_skeleton_morphology1.43353054
69MP0008569_lethality_at_weaning1.37819383
70MP0002896_abnormal_bone_mineralization1.36952196
71MP0009250_abnormal_appendicular_skeleto1.36867102
72MP0002876_abnormal_thyroid_physiology1.36178603
73MP0002882_abnormal_neuron_morphology1.33959060
74MP0003122_maternal_imprinting1.32430220
75MP0005023_abnormal_wound_healing1.32268057
76MP0003942_abnormal_urinary_system1.31717859
77MP0005409_darkened_coat_color1.31627863
78MP0009053_abnormal_anal_canal1.30122626
79MP0000631_abnormal_neuroendocrine_gland1.30090392
80MP0003385_abnormal_body_wall1.27276467
81MP0003941_abnormal_skin_development1.27236378
82MP0001879_abnormal_lymphatic_vessel1.25975071
83MP0000751_myopathy1.24518859
84MP0004742_abnormal_vestibular_system1.24518189
85MP0002066_abnormal_motor_capabilities/c1.24009214
86MP0002877_abnormal_melanocyte_morpholog1.23400923
87MP0010030_abnormal_orbit_morphology1.21479295
88MP0005595_abnormal_vascular_smooth1.21308368
89MP0003283_abnormal_digestive_organ1.20491110
90MP0004885_abnormal_endolymph1.19737160
91MP0002060_abnormal_skin_morphology1.17575805
92MP0000733_abnormal_muscle_development1.11583499
93MP0004134_abnormal_chest_morphology1.10823853
94MP0001243_abnormal_dermal_layer1.10242336
95MP0010352_gastrointestinal_tract_polyps1.09919667
96MP0002152_abnormal_brain_morphology1.03152934
97MP0004142_abnormal_muscle_tone1.02004782
98MP0005379_endocrine/exocrine_gland_phen1.00742502
99MP0003755_abnormal_palate_morphology0.98323844
100MP0000678_abnormal_parathyroid_gland0.98132403
101MP0003633_abnormal_nervous_system0.97620963
102MP0003183_abnormal_peptide_metabolism0.97073802
103MP0000003_abnormal_adipose_tissue0.96804219
104MP0001963_abnormal_hearing_physiology0.95671716
105MP0005394_taste/olfaction_phenotype0.95094466
106MP0005499_abnormal_olfactory_system0.95094466
107MP0005551_abnormal_eye_electrophysiolog0.94714307
108MP0003329_amyloid_beta_deposits0.94108051
109MP0002069_abnormal_eating/drinking_beha0.93604899
110MP0006072_abnormal_retinal_apoptosis0.92274617
111MP0000428_abnormal_craniofacial_morphol0.91574025
112MP0002177_abnormal_outer_ear0.89044194
113MP0002108_abnormal_muscle_morphology0.88158110
114MP0000049_abnormal_middle_ear0.86166048
115MP0002693_abnormal_pancreas_physiology0.85299847
116MP0000762_abnormal_tongue_morphology0.84736635
117MP0005197_abnormal_uvea_morphology0.84713578
118MP0002752_abnormal_somatic_nervous0.83238812
119MP0000015_abnormal_ear_pigmentation0.82918995
120MP0003631_nervous_system_phenotype0.82290953
121MP0002751_abnormal_autonomic_nervous0.82203903
122MP0001299_abnormal_eye_distance/0.82125573
123MP0000759_abnormal_skeletal_muscle0.81712067
124MP0002229_neurodegeneration0.81413562
125MP0004043_abnormal_pH_regulation0.81293604
126MP0000026_abnormal_inner_ear0.77498784
127MP0002102_abnormal_ear_morphology0.75983086
128MP0001177_atelectasis0.75890170
129MP0003634_abnormal_glial_cell0.75462066
130MP0003935_abnormal_craniofacial_develop0.75067100
131MP0004085_abnormal_heartbeat0.74776654
132MP0000681_abnormal_thyroid_gland0.74653364
133MP0000163_abnormal_cartilage_morphology0.72991731
134MP0000432_abnormal_head_morphology0.71514207
135MP0002116_abnormal_craniofacial_bone0.71304009
136MP0001664_abnormal_digestion0.70871227
137MP0001485_abnormal_pinna_reflex0.69936264
138MP0005535_abnormal_body_temperature0.69847932
139MP0002163_abnormal_gland_morphology0.69781736
140MP0002932_abnormal_joint_morphology0.68048985
141MP0002128_abnormal_blood_circulation0.66978285
142MP0002114_abnormal_axial_skeleton0.65807024
143MP0009379_abnormal_foot_pigmentation0.65502841
144MP0008789_abnormal_olfactory_epithelium0.65496255
145MP0001944_abnormal_pancreas_morphology0.65323558
146MP0002081_perinatal_lethality0.64698711
147MP0000749_muscle_degeneration0.64103129
148MP0000462_abnormal_digestive_system0.63554254
149MP0000013_abnormal_adipose_tissue0.63438791
150MP0005248_abnormal_Harderian_gland0.62841991
151MP0005171_absent_coat_pigmentation0.61867208
152MP0003115_abnormal_respiratory_system0.61512465
153MP0008872_abnormal_physiological_respon0.61071154
154MP0003861_abnormal_nervous_system0.59219531
155MP0001915_intracranial_hemorrhage0.58767578
156MP0003937_abnormal_limbs/digits/tail_de0.58739796
157MP0003172_abnormal_lysosome_physiology0.58602228
158MP0000538_abnormal_urinary_bladder0.58128308
159MP0008961_abnormal_basal_metabolism0.57894555
160MP0002113_abnormal_skeleton_development0.57013174
161MP0001614_abnormal_blood_vessel0.56790690
162MP0000566_synostosis0.56644815
163MP0001849_ear_inflammation0.55342487

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.52266501
2Protrusio acetabuli (HP:0003179)6.65391762
3Focal motor seizures (HP:0011153)5.88207739
4Myokymia (HP:0002411)4.96935913
5Ankle contracture (HP:0006466)4.79141343
6Visual hallucinations (HP:0002367)4.56650038
7Epileptic encephalopathy (HP:0200134)4.50309240
8Aortic dissection (HP:0002647)4.45357205
9Focal seizures (HP:0007359)4.31580171
10Vascular tortuosity (HP:0004948)4.22710424
11Febrile seizures (HP:0002373)4.22388174
12Limb dystonia (HP:0002451)4.12374703
13Aortic aneurysm (HP:0004942)4.07312867
14Follicular hyperkeratosis (HP:0007502)4.03784468
15Abnormality of dentin (HP:0010299)3.98402398
16Soft skin (HP:0000977)3.95238813
17Progressive cerebellar ataxia (HP:0002073)3.84738750
18Bladder diverticulum (HP:0000015)3.81818898
19Spinal rigidity (HP:0003306)3.80863406
20Atrophic scars (HP:0001075)3.77615578
21Arterial tortuosity (HP:0005116)3.74139898
22Genu recurvatum (HP:0002816)3.67571035
23Type 1 muscle fiber predominance (HP:0003803)3.61443000
24Fragile skin (HP:0001030)3.50981951
25Shallow orbits (HP:0000586)3.50175422
26Slender build (HP:0001533)3.47832531
27Wormian bones (HP:0002645)3.44240327
28Broad metatarsal (HP:0001783)3.37337797
29Atonic seizures (HP:0010819)3.28212623
30Mutism (HP:0002300)3.26730724
31Neonatal short-limb short stature (HP:0008921)3.25147385
32Bowel diverticulosis (HP:0005222)3.23752977
33Hypoventilation (HP:0002791)3.22054921
34Broad-based gait (HP:0002136)3.19922407
35Supranuclear gaze palsy (HP:0000605)3.10679551
36Generalized tonic-clonic seizures (HP:0002069)3.10167699
37Absence seizures (HP:0002121)3.06549274
38Papilledema (HP:0001085)3.01140719
39Agitation (HP:0000713)2.98144758
40Excessive salivation (HP:0003781)2.97574285
41Drooling (HP:0002307)2.97574285
42Epileptiform EEG discharges (HP:0011182)2.96907222
43EEG with generalized epileptiform discharges (HP:0011198)2.92174115
44Hyperventilation (HP:0002883)2.91931388
45Hypsarrhythmia (HP:0002521)2.79128426
46Ankle clonus (HP:0011448)2.79126699
47Gait imbalance (HP:0002141)2.76827359
48Action tremor (HP:0002345)2.76723862
49Wrist flexion contracture (HP:0001239)2.75697085
50Dialeptic seizures (HP:0011146)2.75218227
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69820348
52Cervical subluxation (HP:0003308)2.66342134
53Blue sclerae (HP:0000592)2.66103439
54Peritonitis (HP:0002586)2.64940322
55Hyperextensible skin (HP:0000974)2.64757808
56Mitral valve prolapse (HP:0001634)2.61913584
57Mildly elevated creatine phosphokinase (HP:0008180)2.61732947
58Poor eye contact (HP:0000817)2.61519972
59Upper limb amyotrophy (HP:0009129)2.59007672
60Distal upper limb amyotrophy (HP:0007149)2.59007672
61Mitral regurgitation (HP:0001653)2.56575417
62Dilatation of the ascending aorta (HP:0005111)2.55661845
63Polyphagia (HP:0002591)2.52724735
64Absent speech (HP:0001344)2.51775055
65Overgrowth (HP:0001548)2.49880360
66Anxiety (HP:0000739)2.47651565
67Spondylolisthesis (HP:0003302)2.47422178
68Diplopia (HP:0000651)2.46003193
69Abnormality of binocular vision (HP:0011514)2.46003193
70Aortic valve stenosis (HP:0001650)2.45801017
71Joint laxity (HP:0001388)2.45188959
72Amblyopia (HP:0000646)2.43921549
73Abnormal eating behavior (HP:0100738)2.43832649
74Urinary bladder sphincter dysfunction (HP:0002839)2.42841734
75Progressive inability to walk (HP:0002505)2.42321468
76Aortic regurgitation (HP:0001659)2.41850483
77Abnormality of calcium-phosphate metabolism (HP:0100530)2.41097453
78Hypothermia (HP:0002045)2.41021072
79Depression (HP:0000716)2.38770376
80Elbow flexion contracture (HP:0002987)2.38590715
81Genetic anticipation (HP:0003743)2.37703054
82Increased variability in muscle fiber diameter (HP:0003557)2.36296790
83Fetal akinesia sequence (HP:0001989)2.35449383
84Abnormal ciliary motility (HP:0012262)2.35382873
85Akinesia (HP:0002304)2.34042172
86Gaze-evoked nystagmus (HP:0000640)2.32936917
87Wide anterior fontanel (HP:0000260)2.32809819
88Obstructive sleep apnea (HP:0002870)2.31797182
89Vertebral compression fractures (HP:0002953)2.31349708
90Absent eyebrow (HP:0002223)2.30557825
91Mild short stature (HP:0003502)2.29938336
92Hemiparesis (HP:0001269)2.29080086
93Truncal ataxia (HP:0002078)2.28926502
94Ulnar bowing (HP:0003031)2.28273436
95Hand muscle atrophy (HP:0009130)2.24382619
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.23761769
97Absent/shortened dynein arms (HP:0200106)2.23761769
98Inability to walk (HP:0002540)2.23311351
99Hyperacusis (HP:0010780)2.22637700
100Torticollis (HP:0000473)2.22484300
101Unilateral renal agenesis (HP:0000122)2.21615200
102Medial flaring of the eyebrow (HP:0010747)2.20243203
103Pheochromocytoma (HP:0002666)2.20224315
104Biconcave vertebral bodies (HP:0004586)2.19316682
105Coronal craniosynostosis (HP:0004440)2.18263710
106Decreased circulating renin level (HP:0003351)2.17550614
107Cerebral aneurysm (HP:0004944)2.16912376
108Short nail (HP:0001799)2.14811055
109Abnormality of salivation (HP:0100755)2.14481843
110Impaired vibration sensation in the lower limbs (HP:0002166)2.13717097
111Abnormal social behavior (HP:0012433)2.13225578
112Impaired social interactions (HP:0000735)2.13225578
113Lower limb amyotrophy (HP:0007210)2.13168178
114Disproportionate tall stature (HP:0001519)2.12502763
115Abnormality of the corticospinal tract (HP:0002492)2.11451779
116Megalencephaly (HP:0001355)2.10046871
117Hepatoblastoma (HP:0002884)2.09949028
118Blue irides (HP:0000635)2.08063120
119Achilles tendon contracture (HP:0001771)2.07717304
120Renal duplication (HP:0000075)2.07207494
121Abnormality of the acetabulum (HP:0003170)2.06495776
122Limb-girdle muscle weakness (HP:0003325)2.06145387
123Mitral stenosis (HP:0001718)2.04404965
124Lissencephaly (HP:0001339)2.03978285
125Long toe (HP:0010511)2.03872265
126Protruding tongue (HP:0010808)2.03447107
127Neurofibrillary tangles (HP:0002185)2.02107720
128Deviation of the hallux (HP:0010051)2.01653129
129Abnormal respiratory motile cilium physiology (HP:0012261)2.01497544
130Distal lower limb amyotrophy (HP:0008944)2.01346438
131Round ear (HP:0100830)2.00306468
132Cardiovascular calcification (HP:0011915)2.00005314
133Nephrogenic diabetes insipidus (HP:0009806)1.99855672
134Hallux valgus (HP:0001822)1.99176543
135Elfin facies (HP:0004428)1.98891700
136Congenital primary aphakia (HP:0007707)1.98883704
137Failure to thrive in infancy (HP:0001531)1.98694360
138Inappropriate behavior (HP:0000719)1.98361358
139Stereotypic behavior (HP:0000733)1.98160065
140Focal dystonia (HP:0004373)1.97725255
141Pancreatic fibrosis (HP:0100732)1.96970475
142Amyotrophic lateral sclerosis (HP:0007354)1.96834013
143Postural instability (HP:0002172)1.96141822
144Abnormal respiratory motile cilium morphology (HP:0005938)1.96079421
145Abnormal respiratory epithelium morphology (HP:0012253)1.96079421
146Neoplasm of the adrenal cortex (HP:0100641)1.95738064
147Abnormal delivery (HP:0001787)1.95611825
148Dysdiadochokinesis (HP:0002075)1.95554152
149Abnormality of skeletal muscle fiber size (HP:0012084)1.94536607
150Impaired smooth pursuit (HP:0007772)1.93830224
151Aneurysm (HP:0002617)1.92276958
152Morphological abnormality of the middle ear (HP:0008609)1.91263064
153Sleep apnea (HP:0010535)1.91256118
154Ectopia lentis (HP:0001083)1.89384956
155Abnormal hair whorl (HP:0010721)1.87445099
156Cerebral inclusion bodies (HP:0100314)1.87277229
157Specific learning disability (HP:0001328)1.87223399
158Hydroureter (HP:0000072)1.86772879
159Delayed gross motor development (HP:0002194)1.84588045
160Flat cornea (HP:0007720)1.84438981
161Generalized hypopigmentation of hair (HP:0011358)1.83829676
162Bradykinesia (HP:0002067)1.83488266
163Hypoplasia of the brainstem (HP:0002365)1.82895013
164Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82895013
165Spastic gait (HP:0002064)1.82201116
166Urinary urgency (HP:0000012)1.81564738
167Broad ribs (HP:0000885)1.81182169
168Insomnia (HP:0100785)1.80551486
169True hermaphroditism (HP:0010459)1.77756693
170Thoracolumbar scoliosis (HP:0002944)1.77353521
171Protruding ear (HP:0000411)1.77172664
172Increased connective tissue (HP:0009025)1.76849354
173Camptodactyly of toe (HP:0001836)1.76759272
174Absent frontal sinuses (HP:0002688)1.76546263
175Dysmetria (HP:0001310)1.76444895
176Hyperphosphatemia (HP:0002905)1.76281602
177Lower limb muscle weakness (HP:0007340)1.76137440
178Craniofacial dystonia (HP:0012179)1.76006627
179Pulmonic stenosis (HP:0001642)1.75992963
180Bradycardia (HP:0001662)1.75640407
181Neuroendocrine neoplasm (HP:0100634)1.75577946
182Tibial bowing (HP:0002982)1.75549344
183Nuclear cataract (HP:0100018)1.74275155
184Hyperthyroidism (HP:0000836)1.74270068
185Joint stiffness (HP:0001387)1.72825867
186Abnormality of the Achilles tendon (HP:0005109)1.72734649
187Nonimmune hydrops fetalis (HP:0001790)1.72470572
188Congenital glaucoma (HP:0001087)1.71129268
189Generalized amyotrophy (HP:0003700)1.71090538
190Difficulty climbing stairs (HP:0003551)1.70083625
191Osteolytic defects of the hand bones (HP:0009699)1.69851202
192Osteolytic defects of the phalanges of the hand (HP:0009771)1.69851202
193Bowed forearm bones (HP:0003956)1.68027910
194Bowing of the arm (HP:0006488)1.68027910
195Knee flexion contracture (HP:0006380)1.65682766
196Spinal cord compression (HP:0002176)1.65168814
197Infantile muscular hypotonia (HP:0008947)1.64347608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.45868604
2NTRK34.21023114
3MYLK3.45671549
4PTK23.15969550
5CASK3.10823097
6PDGFRA3.06644769
7EPHA42.96415220
8LIMK12.77565355
9MAP2K72.74519624
10EPHB22.67898545
11TESK12.55169688
12MAP3K92.52850042
13NTRK22.49880777
14MINK12.49245882
15TTN2.48672978
16MAP3K42.36986560
17SIK22.35866369
18SIK32.30656578
19MAPK132.17393173
20PAK22.12769983
21DDR22.02608974
22TNIK1.93623137
23DAPK21.86715753
24MAP3K121.86310138
25LATS11.82035761
26INSRR1.76000078
27NEK91.67691976
28MOS1.65384074
29ERBB31.59813951
30TRIB31.58144182
31PAK61.57846830
32PHKG21.56929111
33PHKG11.56929111
34NTRK11.55876549
35MET1.46728491
36PLK21.46523877
37GRK51.45960556
38ICK1.42026476
39ERBB41.39871692
40DYRK21.37049231
41CDK51.35725465
42PAK41.34943438
43RIPK11.31101853
44CAMKK11.29538741
45KSR11.29164304
46PRPF4B1.28139476
47MAP3K21.27817854
48TGFBR21.27228908
49PRKD31.25391697
50ROCK21.20806504
51MAP2K41.20584835
52EPHB11.19806763
53PRKCG1.19593888
54CSNK1G21.13288687
55LATS21.09195183
56PTK2B1.08234661
57FLT31.08206451
58DAPK11.07745014
59CDK121.05557726
60PRKG21.02847144
61MARK21.02201578
62CAMKK21.01986612
63DYRK1A1.01684212
64SGK21.01555844
65ROCK11.01138376
66ILK0.99962669
67BMPR20.98826249
68UHMK10.92508687
69SGK2230.92210041
70SGK4940.92210041
71PDGFRB0.91918294
72CAMK2A0.91843541
73PNCK0.87775209
74PRKCE0.87059227
75EPHA20.85460852
76KSR20.85148216
77ABL20.84827669
78DMPK0.83669503
79PRKCH0.82388144
80PAK30.81970160
81RET0.76157460
82MTOR0.75307111
83AKT30.74748668
84DAPK30.73890322
85WNK30.71509546
86CAMK2B0.71243130
87TRPM70.71089846
88STK380.70439464
89CDC42BPA0.70173754
90ADRBK20.69195950
91RPS6KA20.66458850
92SGK10.66009289
93CAMK1G0.64736457
94SGK30.64247936
95PRKCZ0.64246763
96CSNK1G30.64159122
97CAMK10.63685307
98FES0.63264715
99PKN10.62155021
100IRAK30.62133045
101CDK180.60355514
102SIK10.60278131
103PAK10.59873649
104NEK60.58742296
105RIPK40.58284531
106STK110.57505742
107MAP3K60.56962746
108CDK140.56420132
109TIE10.55406220
110HIPK20.55095816
111CDK150.54915141
112CAMK2G0.54492308
113DYRK1B0.53881846
114CSNK1A1L0.52238667
115BMPR1B0.50668417
116WNK10.50629286
117GRK70.50570927
118BRAF0.50472757
119MAPK150.49005333
120PIK3CG0.48940203
121GSK3A0.48155599
122CDK80.48065811
123BRSK10.47490753
124BCR0.46977797
125CDK11A0.46054334
126MAP2K10.43722782
127CCNB10.42647298
128PRKD20.42384724
129TAOK10.42371367
130PKN20.40751800
131CSNK1G10.39858427
132STK38L0.39836365
133TAOK20.39259449
134MAP3K10.38896376
135FYN0.38332321
136RPS6KA30.38291231
137FRK0.38283115
138PRKG10.37300219
139CAMK2D0.37220211
140CDK30.36950258
141ADRBK10.36709041
142STK30.35623990
143ALK0.35149808
144MAP2K60.34807288
145ARAF0.34233948
146MAPK120.33368490
147AURKA0.32842733
148IRAK20.32799010
149PRKACA0.32495398
150RPS6KB10.32284082
151CAMK40.32233762
152NEK20.31792359
153LMTK20.31783050
154MAPK100.30804481

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55137090
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07280248
3ECM-receptor interaction_Homo sapiens_hsa045122.76105473
4Circadian entrainment_Homo sapiens_hsa047132.61702829
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57288920
6Olfactory transduction_Homo sapiens_hsa047402.52722524
7GABAergic synapse_Homo sapiens_hsa047272.51460777
8Morphine addiction_Homo sapiens_hsa050322.48132094
9Focal adhesion_Homo sapiens_hsa045102.45492523
10Insulin secretion_Homo sapiens_hsa049112.42235967
11Glutamatergic synapse_Homo sapiens_hsa047242.39747207
12Amphetamine addiction_Homo sapiens_hsa050312.38342554
13Long-term potentiation_Homo sapiens_hsa047202.25619013
14Dopaminergic synapse_Homo sapiens_hsa047282.23712807
15Cocaine addiction_Homo sapiens_hsa050302.18331785
16Taste transduction_Homo sapiens_hsa047422.12138684
17Cholinergic synapse_Homo sapiens_hsa047252.05916785
18Serotonergic synapse_Homo sapiens_hsa047262.01609387
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77663709
20Salivary secretion_Homo sapiens_hsa049701.77113329
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77028863
22Long-term depression_Homo sapiens_hsa047301.69540353
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68124625
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67732663
25Hippo signaling pathway_Homo sapiens_hsa043901.67605923
26Renin secretion_Homo sapiens_hsa049241.65729417
27Proteoglycans in cancer_Homo sapiens_hsa052051.62877822
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.58708794
29Type II diabetes mellitus_Homo sapiens_hsa049301.49515274
30Gastric acid secretion_Homo sapiens_hsa049711.48521343
31Adherens junction_Homo sapiens_hsa045201.47689397
32Calcium signaling pathway_Homo sapiens_hsa040201.43748877
33Axon guidance_Homo sapiens_hsa043601.41418631
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40953519
35Collecting duct acid secretion_Homo sapiens_hsa049661.38719338
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38392697
37Oxytocin signaling pathway_Homo sapiens_hsa049211.36133653
38Protein digestion and absorption_Homo sapiens_hsa049741.33952046
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33742472
40Gap junction_Homo sapiens_hsa045401.32616904
41Amoebiasis_Homo sapiens_hsa051461.31077468
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30409908
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29034993
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.21048856
45Hedgehog signaling pathway_Homo sapiens_hsa043401.20900777
46Type I diabetes mellitus_Homo sapiens_hsa049401.19474686
47GnRH signaling pathway_Homo sapiens_hsa049121.18780678
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17260960
49cAMP signaling pathway_Homo sapiens_hsa040241.16915823
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16313177
51Phototransduction_Homo sapiens_hsa047441.16105587
52Vibrio cholerae infection_Homo sapiens_hsa051101.15316541
53Estrogen signaling pathway_Homo sapiens_hsa049151.13294345
54PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12421834
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10394007
56Basal cell carcinoma_Homo sapiens_hsa052171.08206472
57Bladder cancer_Homo sapiens_hsa052191.06108044
58MicroRNAs in cancer_Homo sapiens_hsa052061.05086543
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02389645
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.02087355
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01159659
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99966945
63Tight junction_Homo sapiens_hsa045300.99582774
64ErbB signaling pathway_Homo sapiens_hsa040120.99299338
65Melanogenesis_Homo sapiens_hsa049160.98044353
66Glioma_Homo sapiens_hsa052140.93797428
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92757020
68TGF-beta signaling pathway_Homo sapiens_hsa043500.92671549
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92223984
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90866931
71Small cell lung cancer_Homo sapiens_hsa052220.90129378
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.89663500
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.86900479
74Pathways in cancer_Homo sapiens_hsa052000.86218285
75Shigellosis_Homo sapiens_hsa051310.84480176
76Circadian rhythm_Homo sapiens_hsa047100.83889904
77Chronic myeloid leukemia_Homo sapiens_hsa052200.83466181
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82727500
79Pancreatic secretion_Homo sapiens_hsa049720.80471743
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79857986
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77194330
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73704943
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73060465
84MAPK signaling pathway_Homo sapiens_hsa040100.69929943
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69406844
86Alcoholism_Homo sapiens_hsa050340.68537790
87Thyroid hormone synthesis_Homo sapiens_hsa049180.67895315
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67545447
89Ras signaling pathway_Homo sapiens_hsa040140.67253334
90Endometrial cancer_Homo sapiens_hsa052130.66783093
91Choline metabolism in cancer_Homo sapiens_hsa052310.64556679
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.64026900
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.61764392
94Wnt signaling pathway_Homo sapiens_hsa043100.61152514
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60861288
96Dorso-ventral axis formation_Homo sapiens_hsa043200.59939338
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.58910861
98Prolactin signaling pathway_Homo sapiens_hsa049170.56458946
99Ovarian steroidogenesis_Homo sapiens_hsa049130.55410580
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.54523540
101Salmonella infection_Homo sapiens_hsa051320.53623116
102Pancreatic cancer_Homo sapiens_hsa052120.52796661
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52429248
104Glucagon signaling pathway_Homo sapiens_hsa049220.52347537
105Prostate cancer_Homo sapiens_hsa052150.51829710
106Oocyte meiosis_Homo sapiens_hsa041140.49706329
107Dilated cardiomyopathy_Homo sapiens_hsa054140.49421795
108AMPK signaling pathway_Homo sapiens_hsa041520.48828098
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47956281
110Rap1 signaling pathway_Homo sapiens_hsa040150.47589260
111Notch signaling pathway_Homo sapiens_hsa043300.47582789
112Colorectal cancer_Homo sapiens_hsa052100.47570529
113Cardiac muscle contraction_Homo sapiens_hsa042600.46175934
114Thyroid cancer_Homo sapiens_hsa052160.44861208
115Renal cell carcinoma_Homo sapiens_hsa052110.44287020
116Rheumatoid arthritis_Homo sapiens_hsa053230.44176818
117N-Glycan biosynthesis_Homo sapiens_hsa005100.43952246
118Chemokine signaling pathway_Homo sapiens_hsa040620.43667624
119Prion diseases_Homo sapiens_hsa050200.42334879
120African trypanosomiasis_Homo sapiens_hsa051430.41009514
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40939463
122Inositol phosphate metabolism_Homo sapiens_hsa005620.40532635
123Phagosome_Homo sapiens_hsa041450.39691512
124Insulin signaling pathway_Homo sapiens_hsa049100.39590737
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39277347
126mTOR signaling pathway_Homo sapiens_hsa041500.37701588
127Regulation of autophagy_Homo sapiens_hsa041400.36902344
128VEGF signaling pathway_Homo sapiens_hsa043700.36433036
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35733042
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35162432
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34677643
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34521250
133Melanoma_Homo sapiens_hsa052180.33789897
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33027641
135Endocytosis_Homo sapiens_hsa041440.29540009

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